Journal article Open Access

A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation

Hamer, D. H.; Hu, S.; Magnuson, V. L.; Hu, N.; Pattatucci, A. M. L.

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      <creatorName>Hamer, D. H.</creatorName>
      <givenName>D. H.</givenName>
      <creatorName>Hu, S.</creatorName>
      <creatorName>Magnuson, V. L.</creatorName>
      <givenName>V. L.</givenName>
      <creatorName>Hu, N.</creatorName>
      <creatorName>Pattatucci, A. M. L.</creatorName>
      <givenName>A. M. L.</givenName>
    <title>A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation</title>
    <date dateType="Issued">1993-08-01</date>
  <resourceType resourceTypeGeneral="JournalArticle"/>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1126/science.8332896</relatedIdentifier>
    <rights rightsURI="">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.</description>
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