Journal article Open Access

A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation

Hamer, D. H.; Hu, S.; Magnuson, V. L.; Hu, N.; Pattatucci, A. M. L.


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{
  "DOI": "10.1126/science.8332896", 
  "author": [
    {
      "family": "Hamer, D. H."
    }, 
    {
      "family": "Hu, S."
    }, 
    {
      "family": "Magnuson, V. L."
    }, 
    {
      "family": "Hu, N."
    }, 
    {
      "family": "Pattatucci, A. M. L."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        1993, 
        8, 
        1
      ]
    ]
  }, 
  "abstract": "The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.", 
  "title": "A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation", 
  "type": "article-journal", 
  "id": "1231257"
}
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