Journal article Open Access

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.

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<oai_dc:dc xmlns:dc="" xmlns:oai_dc="" xmlns:xsi="" xsi:schemaLocation="">
  <dc:creator>Smith, M.</dc:creator>
  <dc:creator>Chen, I.</dc:creator>
  <dc:creator>Zhan, Q.</dc:creator>
  <dc:creator>Bae, I.</dc:creator>
  <dc:creator>Chen, C.</dc:creator>
  <dc:creator>Gilmer, T.</dc:creator>
  <dc:creator>Kastan, M.</dc:creator>
  <dc:creator>O'Connor, P.</dc:creator>
  <dc:creator>Fornace, A.</dc:creator>
  <dc:description>GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.</dc:description>
  <dc:title>Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen</dc:title>
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