Journal article Open Access

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.


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{
  "description": "GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.", 
  "license": "http://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Smith, M."
    }, 
    {
      "@type": "Person", 
      "name": "Chen, I."
    }, 
    {
      "@type": "Person", 
      "name": "Zhan, Q."
    }, 
    {
      "@type": "Person", 
      "name": "Bae, I."
    }, 
    {
      "@type": "Person", 
      "name": "Chen, C."
    }, 
    {
      "@type": "Person", 
      "name": "Gilmer, T."
    }, 
    {
      "@type": "Person", 
      "name": "Kastan, M."
    }, 
    {
      "@type": "Person", 
      "name": "O'Connor, P."
    }, 
    {
      "@type": "Person", 
      "name": "Fornace, A."
    }
  ], 
  "url": "https://zenodo.org/record/1231241", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "1994-11-25", 
  "headline": "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1126/science.7973727", 
  "@id": "https://doi.org/10.1126/science.7973727", 
  "@type": "ScholarlyArticle", 
  "name": "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen"
}
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