Journal article Open Access

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.


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  <identifier identifierType="URL">https://zenodo.org/record/1231241</identifier>
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      <creatorName>Smith, M.</creatorName>
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      <creatorName>Chen, I.</creatorName>
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      <creatorName>Zhan, Q.</creatorName>
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      <creatorName>Gilmer, T.</creatorName>
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      <creatorName>Kastan, M.</creatorName>
      <givenName>M.</givenName>
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      <creatorName>O'Connor, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>O'Connor</familyName>
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      <creatorName>Fornace, A.</creatorName>
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  <titles>
    <title>Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>1994</publicationYear>
  <dates>
    <date dateType="Issued">1994-11-25</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1231241</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1126/science.7973727</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/publicdomain/zero/1.0/legalcode">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.</description>
  </descriptions>
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