Journal article Open Access
Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://zenodo.org/record/1231241</identifier> <creators> <creator> <creatorName>Smith, M.</creatorName> <givenName>M.</givenName> <familyName>Smith</familyName> </creator> <creator> <creatorName>Chen, I.</creatorName> <givenName>I.</givenName> <familyName>Chen</familyName> </creator> <creator> <creatorName>Zhan, Q.</creatorName> <givenName>Q.</givenName> <familyName>Zhan</familyName> </creator> <creator> <creatorName>Bae, I.</creatorName> <givenName>I.</givenName> <familyName>Bae</familyName> </creator> <creator> <creatorName>Chen, C.</creatorName> <givenName>C.</givenName> <familyName>Chen</familyName> </creator> <creator> <creatorName>Gilmer, T.</creatorName> <givenName>T.</givenName> <familyName>Gilmer</familyName> </creator> <creator> <creatorName>Kastan, M.</creatorName> <givenName>M.</givenName> <familyName>Kastan</familyName> </creator> <creator> <creatorName>O'Connor, P.</creatorName> <givenName>P.</givenName> <familyName>O'Connor</familyName> </creator> <creator> <creatorName>Fornace, A.</creatorName> <givenName>A.</givenName> <familyName>Fornace</familyName> </creator> </creators> <titles> <title>Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen</title> </titles> <publisher>Zenodo</publisher> <publicationYear>1994</publicationYear> <dates> <date dateType="Issued">1994-11-25</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1231241</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1126/science.7973727</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="https://creativecommons.org/publicdomain/zero/1.0/legalcode">Creative Commons Zero v1.0 Universal</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.</description> </descriptions> </resource>
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