Journal article Open Access

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.


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{
  "DOI": "10.1126/science.7973727", 
  "author": [
    {
      "family": "Smith, M."
    }, 
    {
      "family": "Chen, I."
    }, 
    {
      "family": "Zhan, Q."
    }, 
    {
      "family": "Bae, I."
    }, 
    {
      "family": "Chen, C."
    }, 
    {
      "family": "Gilmer, T."
    }, 
    {
      "family": "Kastan, M."
    }, 
    {
      "family": "O'Connor, P."
    }, 
    {
      "family": "Fornace, A."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        1994, 
        11, 
        25
      ]
    ]
  }, 
  "abstract": "GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.", 
  "title": "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen", 
  "type": "article-journal", 
  "id": "1231241"
}
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