Journal article Open Access
Smith, M.; Chen, I.; Zhan, Q.; Bae, I.; Chen, C.; Gilmer, T.; Kastan, M.; O'Connor, P.; Fornace, A.
{ "DOI": "10.1126/science.7973727", "author": [ { "family": "Smith, M." }, { "family": "Chen, I." }, { "family": "Zhan, Q." }, { "family": "Bae, I." }, { "family": "Chen, C." }, { "family": "Gilmer, T." }, { "family": "Kastan, M." }, { "family": "O'Connor, P." }, { "family": "Fornace, A." } ], "issued": { "date-parts": [ [ 1994, 11, 25 ] ] }, "abstract": "GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.", "title": "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen", "type": "article-journal", "id": "1231241" }
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