Journal article Open Access

Silencing of Genes Flanking the P1 Plasmid Centromere

Rodionov, O.

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  "description": "Partition modules stabilize bacterial plasmids and chromosomes by actively promoting their segregation into daughter cells. The partition module of plasmid P1 is typical and consists of a centromere site,parS, and genes that encode proteins ParA and ParB. We show that ParB can silence genes flanking parS (to which ParB binds), apparently by polymerizing along the DNA from a nucleation site at parS. Wild-type ParB contacts an extensive region of P1 DNA; silencing-defective ParB proteins, which were found to be partition-defective, are less able to spread. Hence, the silenced structure appears to function in partitioning.", 
  "license": "", 
  "creator": [
      "@type": "Person", 
      "name": "Rodionov, O."
  "headline": "Silencing of Genes Flanking the P1 Plasmid Centromere", 
  "image": "", 
  "datePublished": "1999-01-22", 
  "url": "", 
  "@context": "", 
  "identifier": "", 
  "@id": "", 
  "@type": "ScholarlyArticle", 
  "name": "Silencing of Genes Flanking the P1 Plasmid Centromere"
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