Journal article Open Access

Silencing of Genes Flanking the P1 Plasmid Centromere

Rodionov, O.


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{
  "description": "Partition modules stabilize bacterial plasmids and chromosomes by actively promoting their segregation into daughter cells. The partition module of plasmid P1 is typical and consists of a centromere site,parS, and genes that encode proteins ParA and ParB. We show that ParB can silence genes flanking parS (to which ParB binds), apparently by polymerizing along the DNA from a nucleation site at parS. Wild-type ParB contacts an extensive region of P1 DNA; silencing-defective ParB proteins, which were found to be partition-defective, are less able to spread. Hence, the silenced structure appears to function in partitioning.", 
  "license": "http://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Rodionov, O."
    }
  ], 
  "url": "https://zenodo.org/record/1231147", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "1999-01-22", 
  "headline": "Silencing of Genes Flanking the P1 Plasmid Centromere", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1126/science.283.5401.546", 
  "@id": "https://doi.org/10.1126/science.283.5401.546", 
  "@type": "ScholarlyArticle", 
  "name": "Silencing of Genes Flanking the P1 Plasmid Centromere"
}
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