Journal article Open Access

Silencing of Genes Flanking the P1 Plasmid Centromere

Rodionov, O.


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  <identifier identifierType="URL">https://zenodo.org/record/1231147</identifier>
  <creators>
    <creator>
      <creatorName>Rodionov, O.</creatorName>
      <givenName>O.</givenName>
      <familyName>Rodionov</familyName>
    </creator>
  </creators>
  <titles>
    <title>Silencing of Genes Flanking the P1 Plasmid Centromere</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>1999</publicationYear>
  <dates>
    <date dateType="Issued">1999-01-22</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1231147</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1126/science.283.5401.546</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/publicdomain/zero/1.0/legalcode">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Partition modules stabilize bacterial plasmids and chromosomes by actively promoting their segregation into daughter cells. The partition module of plasmid P1 is typical and consists of a centromere site,parS, and genes that encode proteins ParA and ParB. We show that ParB can silence genes flanking parS (to which ParB binds), apparently by polymerizing along the DNA from a nucleation site at parS. Wild-type ParB contacts an extensive region of P1 DNA; silencing-defective ParB proteins, which were found to be partition-defective, are less able to spread. Hence, the silenced structure appears to function in partitioning.</description>
  </descriptions>
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