Journal article Open Access

Silencing of Genes Flanking the P1 Plasmid Centromere

Rodionov, O.


Citation Style Language JSON Export

{
  "DOI": "10.1126/science.283.5401.546", 
  "abstract": "Partition modules stabilize bacterial plasmids and chromosomes by actively promoting their segregation into daughter cells. The partition module of plasmid P1 is typical and consists of a centromere site,parS, and genes that encode proteins ParA and ParB. We show that ParB can silence genes flanking parS (to which ParB binds), apparently by polymerizing along the DNA from a nucleation site at parS. Wild-type ParB contacts an extensive region of P1 DNA; silencing-defective ParB proteins, which were found to be partition-defective, are less able to spread. Hence, the silenced structure appears to function in partitioning.", 
  "author": [
    {
      "family": "Rodionov, O."
    }
  ], 
  "id": "1231147", 
  "issued": {
    "date-parts": [
      [
        1999, 
        1, 
        22
      ]
    ]
  }, 
  "title": "Silencing of Genes Flanking the P1 Plasmid Centromere", 
  "type": "article-journal"
}
10
4
views
downloads
Views 10
Downloads 4
Data volume 2.7 MB
Unique views 10
Unique downloads 4

Share

Cite as