Journal article Open Access

Molecular targets for AIDS therapy

Mitsuya, H.; Yarchoan, R.; Broder, S.


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  <dc:creator>Mitsuya, H.</dc:creator>
  <dc:creator>Yarchoan, R.</dc:creator>
  <dc:creator>Broder, S.</dc:creator>
  <dc:date>1990-09-28</dc:date>
  <dc:description>The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro. Nucleoside analogs--particularly those belonging to the dideoxynucleoside family--can inhibit reverse transcriptase after anabolic phosphorylation. 3'-Azido-2',3'-dideoxythymidine (AZT) was the first such drug tested in individuals with AIDS, and considerable knowledge of structure-activity relations has emerged for this class of drugs. However, virtually every step in the replication of HIV could serve as a target for a new therapeutic intervention. In the future, non-nucleoside-type drugs will likely become more important in the experimental therapy of AIDS, and antiretroviral therapy will exert major effects against the morbidity and mortality caused by HIV.</dc:description>
  <dc:identifier>https://zenodo.org/record/1230944</dc:identifier>
  <dc:identifier>10.1126/science.1699273</dc:identifier>
  <dc:identifier>oai:zenodo.org:1230944</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/publicdomain/zero/1.0/legalcode</dc:rights>
  <dc:title>Molecular targets for AIDS therapy</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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