Journal article Open Access

Eosinophils: from low- to high-affinity immunoglobulin E receptors

Capron, M.; Gounni, A. Soussi; Morita, M.; Truong, M. J.; Prin, L.; Kinet, J.-P.; Capron, A.


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{
  "DOI": "10.1111/j.1398-9995.1995.tb04270.x", 
  "author": [
    {
      "family": "Capron, M."
    }, 
    {
      "family": "Gounni, A. Soussi"
    }, 
    {
      "family": "Morita, M."
    }, 
    {
      "family": "Truong, M. J."
    }, 
    {
      "family": "Prin, L."
    }, 
    {
      "family": "Kinet, J.-P."
    }, 
    {
      "family": "Capron, A."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        1995, 
        6, 
        1
      ]
    ]
  }, 
  "abstract": "Several experimental approaches have been used to identify immunoglobulin (IgE) binding molecules expressed by human eosinophils. After the description that Fee RII/CD23 identified on eosinophils could participate in IgE binding and IgE\u2010mediated cytotoxicity, Mac2/\u03b5 binding proteins belonging to the S\u2010type lectin family were also detected on human eosinophits. Anti\u2010Mac2 monoclonal antibodies inhibited eosinophil\u2010dependent cytotoxicity towards parasitic targets. More recently, Fc\u03b5 RI was demonstrated on human eosinophils from hypereosinophilic patients. The 3 components of Fc\u03b5 RI, \u03b1, \u03b2 and \u03b3 chains, were detected in eosinophils. The \u03b1 chain of Fc\u03b5 RI was shown to be involved in IgE binding to eosinophils and in the selective release of eosinophil peroxidase. The participation of Fc\u03b5 RI\u2010bearing eosinophils in a protective immune response against a parasitic infection indicates a so far unsuspected function of Fc\u03b5 RI. The interactions between the different types of IgE binding molecules are discussed.", 
  "title": "Eosinophils: from low- to high-affinity immunoglobulin E receptors", 
  "type": "article-journal", 
  "id": "1230625"
}
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