Journal article Open Access

Cloning and Analysis of MAGE-1-Related Genes

Ding, M.; Beck, R. J.; Keller, C. J.; Fenton, R. G.


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  <dc:creator>Ding, M.</dc:creator>
  <dc:creator>Beck, R. J.</dc:creator>
  <dc:creator>Keller, C. J.</dc:creator>
  <dc:creator>Fenton, R. G.</dc:creator>
  <dc:date>1994-07-01</dc:date>
  <dc:description>The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using reverse transcription polymerase chain reaction and cDNA cloning. We have examined isolated five full-length cDNAs from DM150 which were identified as MAGE-1, MAGE-3, MAGE-12 and two previously undescribed MAGE, MAGE-3b and MAGE-X2. DNA sequence analysis of the coding regions of the MAGE-3b and MAGE-X2 genes revealed 83% and 88% identity with MAGE-1, while MAGE-3b was 98% homologous with the full length MAGE-3 clone. The predicted amino acid sequences of MAGE-X2 and MAGE-3b contain consensus HLA-A1 peptide binding motifs, suggesting that, like MAGE-1, they may code for tumor-associated antigens. In addition, a nonamer peptide encoded by both the MAGE-3 and MAGE-12 genes was shown by direct binding studies to contain an aggretope for HLA-A2.</dc:description>
  <dc:identifier>https://zenodo.org/record/1229420</dc:identifier>
  <dc:identifier>10.1006/bbrc.1994.1963</dc:identifier>
  <dc:identifier>oai:zenodo.org:1229420</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://creativecommons.org/publicdomain/zero/1.0/legalcode</dc:rights>
  <dc:title>Cloning and Analysis of MAGE-1-Related Genes</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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