Journal article Open Access

Cloning and Analysis of MAGE-1-Related Genes

Ding, M.; Beck, R. J.; Keller, C. J.; Fenton, R. G.

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  <identifier identifierType="URL"></identifier>
      <creatorName>Ding, M.</creatorName>
      <creatorName>Beck, R. J.</creatorName>
      <givenName>R. J.</givenName>
      <creatorName>Keller, C. J.</creatorName>
      <givenName>C. J.</givenName>
      <creatorName>Fenton, R. G.</creatorName>
      <givenName>R. G.</givenName>
    <title>Cloning and Analysis of MAGE-1-Related Genes</title>
    <date dateType="Issued">1994-07-01</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1006/bbrc.1994.1963</relatedIdentifier>
    <rights rightsURI="">Creative Commons Zero v1.0 Universal</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using reverse transcription polymerase chain reaction and cDNA cloning. We have examined isolated five full-length cDNAs from DM150 which were identified as MAGE-1, MAGE-3, MAGE-12 and two previously undescribed MAGE, MAGE-3b and MAGE-X2. DNA sequence analysis of the coding regions of the MAGE-3b and MAGE-X2 genes revealed 83% and 88% identity with MAGE-1, while MAGE-3b was 98% homologous with the full length MAGE-3 clone. The predicted amino acid sequences of MAGE-X2 and MAGE-3b contain consensus HLA-A1 peptide binding motifs, suggesting that, like MAGE-1, they may code for tumor-associated antigens. In addition, a nonamer peptide encoded by both the MAGE-3 and MAGE-12 genes was shown by direct binding studies to contain an aggretope for HLA-A2.</description>
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