Journal article Open Access

Cloning and Analysis of MAGE-1-Related Genes

Ding, M.; Beck, R. J.; Keller, C. J.; Fenton, R. G.


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{
  "DOI": "10.1006/bbrc.1994.1963", 
  "abstract": "The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using reverse transcription polymerase chain reaction and cDNA cloning. We have examined isolated five full-length cDNAs from DM150 which were identified as MAGE-1, MAGE-3, MAGE-12 and two previously undescribed MAGE, MAGE-3b and MAGE-X2. DNA sequence analysis of the coding regions of the MAGE-3b and MAGE-X2 genes revealed 83% and 88% identity with MAGE-1, while MAGE-3b was 98% homologous with the full length MAGE-3 clone. The predicted amino acid sequences of MAGE-X2 and MAGE-3b contain consensus HLA-A1 peptide binding motifs, suggesting that, like MAGE-1, they may code for tumor-associated antigens. In addition, a nonamer peptide encoded by both the MAGE-3 and MAGE-12 genes was shown by direct binding studies to contain an aggretope for HLA-A2.", 
  "author": [
    {
      "family": "Ding, M."
    }, 
    {
      "family": "Beck, R. J."
    }, 
    {
      "family": "Keller, C. J."
    }, 
    {
      "family": "Fenton, R. G."
    }
  ], 
  "id": "1229420", 
  "issued": {
    "date-parts": [
      [
        1994, 
        7, 
        1
      ]
    ]
  }, 
  "title": "Cloning and Analysis of MAGE-1-Related Genes", 
  "type": "article-journal"
}
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