Journal article Open Access

Fanconi anemia protein complex is a novel target of the IKK signalsome

Otsuki, Tetsuya; Young, David B.; Sasaki, Dennis T.; Pando, Matthew P.; Li, Jianwu; Manning, Anthony; Hoekstra, Merl; Hoatlin, Maureen E.; Mercurio, Frank; Liu, Johnson M.


Citation Style Language JSON Export

{
  "DOI": "10.1002/jcb.10270", 
  "author": [
    {
      "family": "Otsuki, Tetsuya"
    }, 
    {
      "family": "Young, David B."
    }, 
    {
      "family": "Sasaki, Dennis T."
    }, 
    {
      "family": "Pando, Matthew P."
    }, 
    {
      "family": "Li, Jianwu"
    }, 
    {
      "family": "Manning, Anthony"
    }, 
    {
      "family": "Hoekstra, Merl"
    }, 
    {
      "family": "Hoatlin, Maureen E."
    }, 
    {
      "family": "Mercurio, Frank"
    }, 
    {
      "family": "Liu, Johnson M."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2002, 
        1, 
        1
      ]
    ]
  }, 
  "abstract": "Fanconi anemia (FA), a genetic disorder predisposing to aplastic anemia and cancer, is characterized by hypersensitivity to DNA\u2010damaging agents and oxidative stress. Five of the cloned FA proteins (FANCA, FANCC, FANCE, FANCF, FANCG) appear to be involved in a common functional pathway that is required for the monoubiquitination of a sixth gene product, FANCD2. Here, we report that FANCA associates with the I\u03baB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus\u2010dependent changes in phosphorylation, which are blocked by kinase\u2010inactive IKK2 (IKK2 K\u2009>\u2009M). When exposed to mitomycin C, cells expressing IKK2 K\u2009>\u2009M develop a cell cycle abnormality characteristic of FA. Thus, FANCA may function to recruit IKK2, thus providing the cell a means of rapidly responding to stress. J. Cell. Biochem. 86: 613\u2013623, 2002", 
  "title": "Fanconi anemia protein complex is a novel target of the IKK signalsome", 
  "type": "article-journal", 
  "id": "1229210"
}
92
77
views
downloads
Views 92
Downloads 77
Data volume 22.2 MB
Unique views 91
Unique downloads 76

Share

Cite as