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Synthesizing realistic neural population activity patterns using Generative Adversarial Networks

Molano-Mazon, Manuel; Onken, Arno; Piasini, Eugenio; Panzeri, Stefano


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  <identifier identifierType="DOI">10.5281/zenodo.1217051</identifier>
  <creators>
    <creator>
      <creatorName>Molano-Mazon, Manuel</creatorName>
      <givenName>Manuel</givenName>
      <familyName>Molano-Mazon</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-9140-3571</nameIdentifier>
      <affiliation>Laboratory of Neural Computation, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Onken, Arno</creatorName>
      <givenName>Arno</givenName>
      <familyName>Onken</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7387-5535</nameIdentifier>
      <affiliation>Laboratory of Neural Computation, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy;  University of Edinburgh, Edinburgh EH8 9AB, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Piasini, Eugenio</creatorName>
      <givenName>Eugenio</givenName>
      <familyName>Piasini</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0384-7699</nameIdentifier>
      <affiliation>Laboratory of Neural Computation, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy; University of Pennsylvania, Philadelphia, PA 19104</affiliation>
    </creator>
    <creator>
      <creatorName>Panzeri, Stefano</creatorName>
      <givenName>Stefano</givenName>
      <familyName>Panzeri</familyName>
      <affiliation>Laboratory of Neural Computation, Istituto Italiano di Tecnologia, 38068 Rovereto (TN), Italy</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesizing realistic neural population activity patterns using Generative Adversarial Networks</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2018</publicationYear>
  <subjects>
    <subject>GANs</subject>
    <subject>spike train analysis</subject>
    <subject>neuroscience</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2018-05-02</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Text">Conference paper</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1217051</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.1217050</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The ability to synthesize realistic patterns of neural activity is crucial for studying neural information processing. Here we used the Generative Adversarial Networks (GANs) framework to simulate the concerted activity of a population of neurons. We adapted the Wasserstein-GAN variant to facilitate the generation of unconstrained neural population activity patterns while still benefiting from parameter sharing in the temporal domain. We demonstrate that our proposed GAN, which we termed Spike-GAN, generates spike trains that match accurately the first- and second-order statistics of datasets of tens of neurons and also approximates well their higher-order statistics. We applied Spike-GAN to a real dataset recorded from salamander retina and showed that it performs as well as state-of-the-art approaches based on the maximum entropy and the dichotomized Gaussian frameworks. Importantly, Spike-GAN does not require to specify a priori the statistics to be matched by the model, and so constitutes a more flexible method than these alternative approaches. Finally, we show how to exploit a trained Spike-GAN to construct &amp;#39;importance maps&amp;#39; to detect the most relevant statistical structures present in a spike train. Spike-GAN provides a powerful, easy-to-use technique for generating realistic spiking neural activity and for describing the most relevant features of the large-scale neural population recordings studied in modern systems neuroscience.&lt;/p&gt;</description>
    <description descriptionType="Other">This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 699829.</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/H2020/699829/">699829</awardNumber>
      <awardTitle>Encoding and Transmission of Information in the Mouse Somatosensory Cortex</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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