A REVIEW ON CONTROLLED POROSITY OSMOTIC PUMP DRUG DELIVERY SYSTEM & TREATING HYPERTENSION WITH BETA BLOCKERS

A significant milestone in oral NDDS is osmotic drug delivery system. Osmotic system releases a drug at a predetermined zero order delivery rate based on osmosis. The osmotic pressure is a colligative property of a solution in which the magnitude of osmotic pressure of the solution is independent on the number of discrete entities of solute present in the solution. The release rate depends on solubility, molecular weight and activity coefficient of the solute i.e osmogens. Elevated BP is an extremely common disorder affecting millions of people world wide. In most cases rise in B.P is due to increase in total peripheral resistance while cardiac output and heart rate are not high. The beta blockers are used individually or a combination therapy to treat hypertension. The development of oral osmotic systems has a strong and good market potential and it is clear from the marketed products and number of patents granted in the last few years. Beta blockers continue to be first choice drugs recommended by JNC VI & WHO-ISH. Hypertension is termed as ‘Silent killer’ as its symptoms are invisible many times, long term hypertension causes atheroscelerosis, strokes, aneurysm, retinopathy in eyes and amputation of the parts. At this time focus was on developing zero order delivery system. Zero order kinetics would be superior as they maintain steady drug concentration in blood in treating hypertension effectively.