FORMULATION AND IN VITRO EVALUATION OF NIFEDIPINE FLOATING MATRIX TABLETS BY USING NATURAL POLYMERS

In the present research work gastro retentive floating matrix formulation of Nifedipine by using Natural polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimised. Then the formulation was developed by using different concentrations of polymers Xanthan gum, guar gum and Karaya Gum as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations Karaya Gum as polymer were retarded the drug release more than12 hours. whereas in low concentrations the polymer was unable to produce the desired action. The formulations prepared with guar gum were also retarded the drug release up to 12 hours (F6=96.32%). The optimised formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order mechanism of drug release. Keywords: Nifedipine, Xanthan gum, guar gum and Karaya Gum, Floating Tablets