Activity of superoxide dismutase in guinea pigs' bronchi in late periods of experimental allergic alveolitis development and their correction with thiotriazolin

Baida Mariana Ljubomurivna, Fyrduchco – Regeda Mariana Mukchailivna, Regeda Stepan Mukchailovuch. Activity of superoxide dismutase in guinea pigs’ bronchi in late periods of experimental allergic alveolitis development and their correction with thiotriazolin. Journal of Education, Health and Sport. 2017;7(7):1265-1269. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1175268

http://ojs.ukw.edu.pl/index.php/johs/article/view/5291

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

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Received: 01.07.2017. Revised: 02.07.2017. Accepted: 31.07.2017.

Activity of superoxide dismutase in guinea pigs’ bronchi

in late periods of experimental allergic alveolitis development and their correction with thiotriazolin

Mariana Ljubomurivna Baida1, Mariana Mukchailivna Fyrduchco – Regeda2,

Stepan Mukchailovuch Regeda3

Danylo Halytsky Lviv National Medical University

1 Department of pathological physiology, PhD, Assistant Professor

2 Department of pathological physiology, PhD, Assistant Professor

3 Department of pathological physiology, postgraduate student

Lviv, Ukraine

Abstract

The aim of work was to make biochemical investigations for detection of pro-oxidant and antioxidant systems markers in guinea pigs` bronchi before and after treatment of thiotriazolin during experimental allergic alveolitis development. Gradual elevation of conjugated dienes and malonic dialdegyde level in the bronchi was recorded on the 44th day and 54 th of experimental allergic alveolitis development in comparison with intact animals, indicating excessive accumulation of lipid peroxidation products. In the same time activity of superoxide dismutase was reduced. Oxidative stress occurs when the balance between antioxidants and reactive oxygen species(ROS) are disrupted because of either depletion of antioxidants or accumulation of ROS. Reduction of conjugated diene and malondialdehyde content and elevation of catalase activity have been reported in animals with this experimental model of disease after using of thiotriazolin. The study of oxidative stress can provide insights into etiopathogenesis and favour the discovery of new treatments.

Key words: experimental allergic alveolitis, free radicals, superoxyde dismutase, thiotriazolin.