Journal article Open Access

FORMULATION AND EVALUATION OF FLOATING TABLETS OF FAMCICLOVIR USING VARIOUS HYDROPHILIC AND HYDROPHOBIC POLYMERS

K. Ramanji Reddy*, Dr. S. Jaya, Chinnapangu Rajeswari, Dr. Chandaka Madhu

The Study was undertaken with an aim to formulate oro-dispersible tablets of cefuroxime axetil by using superdisintegrants like crospovidone, sodium starch glycolate and Ac-di-sol . Different formulations were prepared varying the superdisintegrant concentration. Preformulation study of the tablet blend was carried out, the tablet blends showed good flowing properties directing for the further course of formulation. The tablets were prepared by direct compression method.Tablets were evaluated for postformulation studies like hardness, weight variation, friability, wetting time, in vitro disintegration time and in vitro dissolution, stability studies.The hardness was found to be in the range of 3.0 -4.0 kg/cm2 .Weight variation was found to be in the range of 240 – 254 mg. Friability was NMT 0.5% meeting the USP limits.Weight variation and hardness of cefuroxime axetil tablets were within range. Wetting time was in the range of 30 to 39.3, as wetting time increases disintegration time of tablet decreases. Wetting time of F9 with superdisintegrants Ac-di-sol shows lower values hence higher disintegration time. Formulations containing of Ac-di-sol showed somewhat lower wetting time than other batches hence showed satisfactory disintegration time. Disintegration time of tablets was evaluated and was found to be in the range of 29±1 to 41±1.52. Lower disintegration time was for F9 formulations containing Ac-di-sol as superdisintegrant. Formulations containing of Ac-di-sol in higher quantity showed good disintegration time. Formulations containing of sodium starch glycolate showed higher disintegration time compared with other formulations. The formulations were stable at both the temperatures maintained for stability studies and were found to be maintaining the same dissolution velocity. Key words: cefuroxime axetil, crospovidone , sodium starch glycolate , Ac-di-sol

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