Journal article Open Access

HUNTINGTON'S DISEASE: UNDERSTANDING THE PATHOPHYSIOLOGY THROUGH THE HUNTINGTIN GENE

Md. Nasrullah


DataCite XML Export

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="DOI">10.5281/zenodo.1162268</identifier>
  <creators>
    <creator>
      <creatorName>Md. Nasrullah</creatorName>
    </creator>
  </creators>
  <titles>
    <title>HUNTINGTON'S DISEASE: UNDERSTANDING THE PATHOPHYSIOLOGY THROUGH THE HUNTINGTIN GENE</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2018</publicationYear>
  <subjects>
    <subject>huntington's disease; Neurodegenerative Disorders; Pathophysiology; Huntingtin gene</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2018-01-29</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1162268</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.1162267</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Huntington&amp;#39;s Disease (HD) is a progressive neurodegenerative disorder. It is an autosomal dominant disorder that is categorized by motor dysfunctions, behavioral and cognitive deficits. Reason for this disease is expansion of the polyglutamine (due to the more CAG repeat) in the amino-terminal region of the exon 1 of the Huntingtin gene (HTT). Furthermore, the mutant HTT gene is occupied in the HD associated changes of neurotransmission for enabling the neurodegeneration. Even though the the important pathophysiology of the HD happens in the caudate and putamen, rest regions of the brain are similarly influenced and also show a significant characteristic in the HD pathophysiology. Until now actual remedy for the HD is not available. As a result, current approaches are directing to the HTT gene expression silencing. It is now taken as the probable way of the management of HD. But the most important thing is, core functions of the HTT gene in the brain of adult subject are presently not clear at all and henceforward the outcome of the continued HTT gene expression suppression of is unpredictable. It could be possibly being tough. This review is based on the pathophysiology of HTT on HD. Keywords: huntington&amp;rsquo;s disease; Neurodegenerative Disorders; Pathophysiology; Huntingtin gene&lt;/p&gt;</description>
  </descriptions>
</resource>
44
29
views
downloads
All versions This version
Views 4446
Downloads 2929
Data volume 27.7 MB27.7 MB
Unique views 4244
Unique downloads 2525

Share

Cite as