1116389
doi
10.5281/zenodo.1116389
oai:zenodo.org:1116389
Goldberg, Arthur P
Icahn School of Medicine at Mount Sinai
Whole-cell model simulations for medicine and bioengineering
Karr, Jonathan R
Icahn School of Medicine at Mount Sinai
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
systems biology
computational biology
dynamical modeling
<p>Whole-cell models predict cell behaviors by modeling all molecular components and their interactions. Recently, we and other developed the first whole-cell model. The model represents the functionality of all 409 characterized genes and 725 metabolites throughout one life cycle of the reduced bacterium <em>Mycoplasma genitalium</em>. This model was validated against a broad range of data and provided insights into many previously unobserved cellular behaviors.</p>
<p>Simulating the behavior of a single cell required modest computing resources – 1 core-day of an Intel E5520 CPU, capable of 3.3×1015 double-precision floating-point operations during the computation. Sampling the organism’s behavior required 128 simulations. Nevertheless, we anticipate that exascale computing resources will be required to use more comprehensive and more accurate whole-cell models to personalize medicine and engineer bacteria.</p>
Zenodo
2015-10-06
info:eu-repo/semantics/other
1116388
1579530476.372572
57104
md5:bb7f26f769918080d2be42aa73f62eaf
https://zenodo.org/records/1116389/files/Goldberg2015.pdf
public
10.5281/zenodo.1116388
isVersionOf
doi