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Protocol : Assessment of the relationship between sodium intake and pre-specified health outcomes, including dose–response relationships, and integration of different lines of evidence for setting DRVs for sodium

EFSA Panel on Dietetic Products, Nutrition and Allergies; Turck, Dominique; Bresson, Jean-Louis; Burlingame, Barbara; Dean, Tara; Fairweather-Tair, Susan; Heinonen, Marina; Hirsch-Ernst, Karen Ildico; Mangelsdorf, Inge; McArdle, Harry; Neuhäuser-Berthold, Monika; Nowicka, Grazyna; Pentieva, Kristina; Sanz, Yolanda; Siani, Alfonso; Sjödin, Anders; Stern, Martin; Tomé, Daniel; Van Loveren, Henk; Vinceti, Marco; Willatts, Peter; Aggett, Peter; Martin, Ambroise; Przyrembel, Hildegard; Aiassa, Elisa; Ciccolallo, Laura; de Sesmaisons Lecarré, Agnès; Munoz Guajardo, Irene; Valtuena Martinez, Silvia; Naska, Androniki


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    <subfield code="a">&lt;p&gt;As part of a series of scientific opinions on dietary references values (DRVs) for micronutrients for the European population, the EFSA&amp;nbsp;Panel on Dietetics Products, Nutrition and Allergies (NDA)&amp;nbsp;&amp;nbsp;is reviewing the scientific evidence to set DRVs for sodium.&lt;/p&gt;

&lt;p&gt;The protocol presented in this document describes the methodology that will be&amp;nbsp;applied for: i) the assessment of possible relationships between sodium intake and health outcomes, including dose-response relationship(s), where applicable, and ii) the integration of different lines of evidence for setting DRVs. In particular,&amp;nbsp;systematic reviews on the relationship between sodium intake and blood pressure, cardiovascular disease, bone mineral density, bone mineral content, and osteoporotic fractures will be conducted.&amp;nbsp;&lt;/p&gt;

&lt;p&gt;The protocol will be implemented in 2018. The outcome will be used&amp;nbsp;by the NDA Panel to complete&amp;nbsp;its scientific opinion on DRVs for sodium.&amp;nbsp;A public consultation will be organised once the scientific opinion is complete (Spring 2019; https://www.efsa.europa.eu/en/calls/consultations). This protocol will be published as an Annex to the scientific opinion (Annex A).&lt;/p&gt;

&lt;p&gt;Further information EFSA&amp;#39;s work on DRVs: https://www.efsa.europa.eu/en/topics/topic/dietary-reference-values-and-dietary-guidelines&lt;/p&gt;</subfield>
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