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Protocol : Assessment of the relationship between sodium intake and pre-specified health outcomes, including dose–response relationships, and integration of different lines of evidence for setting DRVs for sodium

EFSA Panel on Dietetic Products, Nutrition and Allergies; Turck, Dominique; Bresson, Jean-Louis; Burlingame, Barbara; Dean, Tara; Fairweather-Tair, Susan; Heinonen, Marina; Hirsch-Ernst, Karen Ildico; Mangelsdorf, Inge; McArdle, Harry; Neuhäuser-Berthold, Monika; Nowicka, Grazyna; Pentieva, Kristina; Sanz, Yolanda; Siani, Alfonso; Sjödin, Anders; Stern, Martin; Tomé, Daniel; Van Loveren, Henk; Vinceti, Marco; Willatts, Peter; Aggett, Peter; Martin, Ambroise; Przyrembel, Hildegard; Aiassa, Elisa; Ciccolallo, Laura; de Sesmaisons Lecarré, Agnès; Munoz Guajardo, Irene; Valtuena Martinez, Silvia; Naska, Androniki


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      {
        "affiliation": "University of Lille, France", 
        "name": "Turck, Dominique"
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      {
        "affiliation": "Clinique des Enfants Malades, Paris, France", 
        "name": "Bresson, Jean-Louis"
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      {
        "affiliation": "Massey University, New Zealand", 
        "name": "Burlingame, Barbara"
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      {
        "affiliation": "Brighton University, UK", 
        "name": "Dean, Tara"
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      {
        "affiliation": "University of East Anglia, UK", 
        "name": "Fairweather-Tair, Susan"
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      {
        "affiliation": "University of Helsinki, Finland", 
        "name": "Heinonen, Marina"
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      {
        "affiliation": "Federal Institute for Risk Assessment (BfR), Germany", 
        "name": "Hirsch-Ernst, Karen Ildico"
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      {
        "name": "Mangelsdorf, Inge"
      }, 
      {
        "affiliation": "Rowett Research Institute, UK", 
        "name": "McArdle, Harry"
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      {
        "affiliation": "Justus Liebig University Giessen, Germany", 
        "name": "Neuh\u00e4user-Berthold, Monika"
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        "affiliation": "National Food and Nutrition Institute, Poland", 
        "name": "Nowicka, Grazyna"
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        "affiliation": "University of Ulster, UK", 
        "name": "Pentieva, Kristina"
      }, 
      {
        "affiliation": "Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos, Spain", 
        "name": "Sanz, Yolanda"
      }, 
      {
        "affiliation": "National Research Council, Italy", 
        "name": "Siani, Alfonso"
      }, 
      {
        "affiliation": "University of Copenhagen, Denmark", 
        "name": "Sj\u00f6din, Anders"
      }, 
      {
        "affiliation": "University Children's Hospital Tuebingen, Germany", 
        "name": "Stern, Martin"
      }, 
      {
        "affiliation": "AgroParisTech, France", 
        "name": "Tom\u00e9, Daniel"
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      {
        "affiliation": "Maastricht University, the Netherlands", 
        "name": "Van Loveren, Henk"
      }, 
      {
        "affiliation": "University of Modena e Reggio Emilia, Italy", 
        "name": "Vinceti, Marco"
      }, 
      {
        "affiliation": "School of Psychology, University of Dundee, UK", 
        "name": "Willatts, Peter"
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      {
        "affiliation": "University of Lancashire, UK", 
        "name": "Aggett, Peter"
      }, 
      {
        "affiliation": "Facult\u00e9 de M\u00e9decine Lyon, France", 
        "name": "Martin, Ambroise"
      }, 
      {
        "affiliation": "Federal Institute for Risk Assessment  (Bfr), Germany", 
        "name": "Przyrembel, Hildegard"
      }, 
      {
        "affiliation": "EFSA", 
        "name": "Aiassa, Elisa"
      }, 
      {
        "affiliation": "EFSA", 
        "name": "Ciccolallo, Laura"
      }, 
      {
        "affiliation": "EFSA", 
        "name": "de Sesmaisons Lecarr\u00e9, Agn\u00e8s"
      }, 
      {
        "affiliation": "EFSA", 
        "name": "Munoz Guajardo, Irene"
      }, 
      {
        "affiliation": "EFSA", 
        "name": "Valtuena Martinez, Silvia"
      }, 
      {
        "affiliation": "University of Athens, Greece", 
        "name": "Naska, Androniki"
      }
    ], 
    "description": "<p>As part of a series of scientific opinions on dietary references values (DRVs) for micronutrients for the European population, the EFSA&nbsp;Panel on Dietetics Products, Nutrition and Allergies (NDA)&nbsp;&nbsp;is reviewing the scientific evidence to set DRVs for sodium.</p>\n\n<p>The protocol presented in this document describes the methodology that will be&nbsp;applied for: i) the assessment of possible relationships between sodium intake and health outcomes, including dose-response relationship(s), where applicable, and ii) the integration of different lines of evidence for setting DRVs. In particular,&nbsp;systematic reviews on the relationship between sodium intake and blood pressure, cardiovascular disease, bone mineral density, bone mineral content, and osteoporotic fractures will be conducted.&nbsp;</p>\n\n<p>The protocol will be implemented in 2018. The outcome will be used&nbsp;by the NDA Panel to complete&nbsp;its scientific opinion on DRVs for sodium.&nbsp;A public consultation will be organised once the scientific opinion is complete (Spring 2019; https://www.efsa.europa.eu/en/calls/consultations). This protocol will be published as an Annex to the scientific opinion (Annex A).</p>\n\n<p>Further information EFSA&#39;s work on DRVs: https://www.efsa.europa.eu/en/topics/topic/dietary-reference-values-and-dietary-guidelines</p>", 
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      "dietary reference value", 
      "nutrition", 
      "sodium", 
      "bone", 
      "cardiovascular", 
      "systematic review", 
      "protocol", 
      "blood pressure"
    ], 
    "language": "eng", 
    "license": {
      "id": "CC-BY-4.0"
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    "notes": "Contact: agnes.desesmaisons-lecarre@efsa.europa.eu; nda@efsa.europa.eu", 
    "publication_date": "2017-12-14", 
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    "title": "Protocol : Assessment of the relationship between sodium intake and pre-specified health outcomes, including dose\u2013response relationships, and integration of different lines of evidence for setting DRVs for sodium"
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