Journal article Open Access

Application of KL Divergence for Estimation of Each Metabolic Pathway Genes

Shohei Maruyama; Yasuo Matsuyama; Sachiyo Aburatani


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    <subfield code="a">Yasuo Matsuyama</subfield>
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    <subfield code="a">&lt;p&gt;Development of a method to estimate gene functions is&lt;br&gt;
an important task in bioinformatics. One of the approaches for the&lt;br&gt;
annotation is the identification of the metabolic pathway that genes are&lt;br&gt;
involved in. Since gene expression data reflect various intracellular&lt;br&gt;
phenomena, those data are considered to be related with genes&amp;rsquo;&lt;br&gt;
functions. However, it has been difficult to estimate the gene function&lt;br&gt;
with high accuracy. It is considered that the low accuracy of the&lt;br&gt;
estimation is caused by the difficulty of accurately measuring a gene&lt;br&gt;
expression. Even though they are measured under the same condition,&lt;br&gt;
the gene expressions will vary usually. In this study, we proposed a&lt;br&gt;
feature extraction method focusing on the variability of gene&lt;br&gt;
expressions to estimate the genes&amp;#39; metabolic pathway accurately. First,&lt;br&gt;
we estimated the distribution of each gene expression from replicate&lt;br&gt;
data. Next, we calculated the similarity between all gene pairs by KL&lt;br&gt;
divergence, which is a method for calculating the similarity between&lt;br&gt;
distributions. Finally, we utilized the similarity vectors as feature&lt;br&gt;
vectors and trained the multiclass SVM for identifying the genes&amp;#39;&lt;br&gt;
metabolic pathway. To evaluate our developed method, we applied the&lt;br&gt;
method to budding yeast and trained the multiclass SVM for&lt;br&gt;
identifying the seven metabolic pathways. As a result, the accuracy&lt;br&gt;
that calculated by our developed method was higher than the one that&lt;br&gt;
calculated from the raw gene expression data. Thus, our developed&lt;br&gt;
method combined with KL divergence is useful for identifying the&lt;br&gt;
genes&amp;#39; metabolic pathway.&lt;/p&gt;</subfield>
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