Journal article Open Access

Effect of Oral Administration of "Gadagi" Tea on Liver Function in Rats

A. M. Gadanya; M. S. Sule; M. K. Atiku

Effect of oral administration of "Gadagi" tea on liver function was assessed on 50 healthy male albino rats which were grouped and administered with different doses(mg/kg) i.e low dose (380mg/kg, 415mg/kg, 365mg/kg, 315mg/kg for "sak", "sada" and "magani" respectively), standard dose ( 760mg/kg, 830mg/kg, 730mg/kg for "sak-, "sada" and "magani" respectively) and high dose (1500mg/kg, 1700mg/kg and 1460mg/kg for "sak--,"sada" and "magani" groups respectively) for a period of four weeks. Animals that were not administered with the tea constituted the control group. At the end of fourth week, the animals were sacrificed and their serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), and globulins (GLO) were determined. Mean serum ALT and ALP activities were significantly higher (P<0.05) in rats orally administered with high dose of "sak" and those administered with standard dose of "sada" than those of the control group, suggesting a probable impairment of liver function due to liver cytolysis.Mean serum AST, ALT and ALP activities were significantly lower (P<0.05) in rats that were orally administered with high dose of "magani" than that of the control group, suggesting a probable improvement in liver function (due to decrease in liver cytolysis). Mean serum TP, ALB and GLO levels were significantly higher (P<0.05) in rats that were orally administered with the various doses of"sak", "sada" and "magani" than those of the control group. This also suggests a probable improvement in the synthetic function of the liver.Thus, some dosages of "sak" and "sada could be hepatotoxic, whereas "magani" especially at the high dose administered could have pharmacologically positive effect on the liver of the rats.

Files (130.6 kB)
Name Size
130.6 kB Download
  • Doumas, B.T., Waston, W.A. and Briggs, M.A. (1971). Albumin standards and the measurement of serum albumin with bromocresol green. Clinical Chemical Acta, 31: 87-89.
  • Gadanya, A.M. (2011). Biochemical and Toxicological studies on "Gadagi"tea in rats. Ph.D. Thesis Department of Biochemistry, Bayero University Kano, P2.
  • Gadanya, A.M.,Sule, M.S. and Atiku, M.K. (2011). Analysis of some Phytochemicals in "Gadagi" tea commonly consumed in Kano, Nigeria.(Unpublished manuscript). [10] Obi, F.O. and Uneh, E. (2003). pH department prevention of carbon tetrachloride-induced lipoperoxidation in rats by ethanolic extract of Hibiscus rosasinensis petal. Biokeemstri 13:42-50. [11] Atiku, M.K., Adamu, D.J.M., Gadanya, A.M. and Shehu, M.A. (2009). The effect of "Gadagi" tea on liver function and serum glucose concentration in Albino rats. Bayero Journal of Pure and Applied Sciences 2 (1):125-127.
  • Gornall, A.G., Bardawill, C.J. and David, M.M. (1949). Determination of serum proteins by means of buiret reaction. Journal of Biological Chemistry. 28: 177 - 175.
  • Jandrassik, L. and Grof, P. (1938). Colorimetric Method for the Determination Srum Bilirubin. Clinial Biochemistry.297:81.
  • Kent, M., Vande, G. and Struart, I.F.(1999). Concepts of Human Anatomy and Physiology. Fifth edition. D.Van Nostrand Company, New York. Pp 838-845.
  • King, E.J. and Armstrong, A.R. (1964). Determination of serum alkaline phosphatase activity. Canadian Medical Journal 31:376-377.
  • Reitman, S. and Frankel, S. (1957). Colorimetric method for the determination of serum glutamic oxaloacetate and glutamic pyruvic transaminases. Amer. J. Clin. Pathol, 28; 56-61.
  • Wada, H. and Snell, E.E. (1962). Enzymatic transmination of pyridoxamine - pyruvate transaminase. J. Biol. Chem. 237: 133 - 137
All versions This version
Views 00
Downloads 00
Data volume 0 Bytes0 Bytes
Unique views 00
Unique downloads 00


Cite as