10.5281/zenodo.1065005
https://zenodo.org/records/1065005
oai:zenodo.org:1065005
Dustin, Ml
Ml
Dustin
Olszowy, Mw
Mw
Olszowy
Holdorf, Ad
Ad
Holdorf
Li, Jun
Jun
Li
Bromley, Shannon
Shannon
Bromley
Desai, Naishadh
Naishadh
Desai
Widder, Patricia
Patricia
Widder
van der Merwe, Pa Anton
Pa Anton
van der Merwe
Rosenberger, Frederick
Frederick
Rosenberger
Anton van der Merwe, P.
P.
Anton van der Merwe
Allen, Pm
Pm
Allen
Shaw, As
As
Shaw
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Zenodo
1998
1998-09-01
10.5281/zenodo.1065004
Free for private use; right holder retains other rights, including distribution
Recognition of antigen by T cells requires the formation of a specialized junction between the T cell and the antigen-presenting cell. This junction is generated by the recruitment and the exclusion of specific proteins from the contact area. The mechanisms that regulate these events are unknown. Here we demonstrate that ligand engagement of the adhesion molecule, CD2, initiates a process of protein segregation, CD2 clustering, and cytoskeletal polarization. Although protein segregation was not dependent on the cytoplasmic domain of CD2, CD2 clustering and cytoskeletal polarization required an interaction of the CD2 cytoplasmic domain with a novel SH3-containing protein. This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the cytoskeleton.