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This paper aims at overviewing the topics of a research project (CARDIOSENSOR) on the field of health sciences (biomaterials and biomedical engineering). The project has focused on the development of a nanosensor for the assessment of the risk of cardiovascular diseases by the monitoring of C-reactive protein (CRP), which has been currently considered as the best validated inflammatory biomarker associated to cardiovascular diseases. The project involves tasks such as: 1) the development of sensor devices based on field effect transistors (FET): assembly, optimization and validation; 2) application of sensors to the detection of CRP in standard solutions and comparison with enzyme-linked immunosorbent assay (ELISA); and 3) application of sensors to real samples such as blood and saliva and evaluation of their ability to predict the risk of cardiovascular disease.
", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2013-01-20", "publisher": "Zenodo", "references": [ { "reference": "S. Allender, P. Scarborough, V. Peto, M. Rayner, J. Leal, R. Luengo\nFernandez, A. Gray, \"European cardiovascular disease statistics - 2008\", Health Econ., vol. 2008, p. 1-112, 2008." }, { "reference": "V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, W.B. Borden, D.M. Bravata, S. Dai, E.S. Ford, C.S. Fox, H.J. Fullerton, C. Gillespie, S.M. Hailpern, J.A. Heit, V.J. Howard, B.M. Kissela, S.J.\nKittner, D.T. Lackland, J.H. Lichtman, L.D. Lisabeth, D.M. Makuc,\nG.M. Marcus, A. Marelli, D.B. Matchar, C.S. Moy, D. Mozaffarian,\nM.E. Mussolino, G. Nichol, N.P. Paynter, E.Z. Soliman, P.D. Sorlie, N.\nSotoodehnia, T.N. Turan, S.S. Virani, N.D.Wong, D. Woo, M.B. Turner,\n\"Heart disease and stroke statistics - 2012 update. 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Bioelectron., vol. 24, p. 3091-3096, 2009.\n[12] A. Quershi, J.H. Niazi, S. Kallempudi, Y. Gurbuz, \"Label-free\ncapacitive biosensor for sensitive detection of multiple biomarkers using\ngold interdigitated capacitor arrays\", Biosens. Bioelectron., vol. 25, p.\n2318-2323, 2010.\n[13] M.T. Gomes, T.A.P. Rocha, A.C. Duarte, J.A.B.P. Oliveira, \"The\nperformance of a tetramethylammonium fluoride tetrahydrated coated\npiezoelectric crystal for carbon dioxide detection\", Anal. Chim. Acta,\nvol. 355, p. 235-238, 1996.\n[14] T.A.P. Rocha, M.T. Gomes, A.C. Duarte, J.A.B.P. Oliveira, \"Quartz\ncrystal microbalance with gold electrodes as a sensor for monitoring gasphase\nadsorption/desorption of short chain alkylthiol and alkyl sulfides\",\nAnal. Commun., vol. 35, p. 415-416, 1998.\n[15] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, \"Development of a\nfluorosiloxane polymer coated optical fibre sensor for detection of\norganic volatile compounds\", Sens. Actuators B., vol. 132, p. 280-289,\n2008.\n[16] L.I.B. Silva, Rocha-Santos T.A.P., Duarte A.C., \"Comparison of a gas\nchromatography-optical fibre (GC-OF) detector with a gas\nchromatography-flame ionization detector (GC-FID) for determination\nof alcoholic compounds in industrial atmospheres\", Talanta, vol. 76, p.\n395-399, 2008.\n[17] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, \"Sensing of volatile\norganic compounds in indoor atmosphere and confined areas of\nindustrial environments\". Global NEST Journal, vol. 10, 217-225, 2008.\n[18] L.I.B. Silva, F.D.P. Ferreira, T.A.P. Rocha-Santos, A.C. Duarte,\n\"Carbon nanotube field-effect transistor detector associated to gas\nchromatography for speciation of benzene, toluene, ethylbenzene, (o-,\nm- and p-)xylene\", J. Chromatography A, vol. 1216, p. 6517-6521,\n2009.\n[19] C.I.L. Justino, T.A.P. Rocha-Santos, A.C. Duarte, \"Sampling and\ncharacterization of nanoaerosols in different environments\". Trends\nAnal. Chem., vol. 30, p. 554-567, 2011.\n[20] L.I.B. Silva, C.I.L. Justino, I. Lopes, R. Pereira, A.C. Freitas, R. Calado,\nT.A.P. Rocha-Santos, T.S.L. Panteleitchouk, M.E. Pereira, A.C. Duarte,\n\"Optical fiber based methodology for assessment of thiocyanate in\nseawater\" J. Environ. Monitor., vol. 13, 6, 1811-1815, 2011.\n[21] C.I.L. Justino, A.C. Freitas, T.A.P. Rocha-Santos, A.C. Duarte,\n\"Screening of single-walled carbon nanotubes by optical fiber sensing\",\nTalanta, vol. 89, p. 105-108, 2012.\n[22] M.T. Gomes, T.A. Rocha, A.C. Duarte, J.A.B.P. Oliveira,\n\"Determination of sulfur dioxide in wine using a quartz crystal\nmicrobalance\". Anal. Chem., vol. 68, p. 1561-1564, 1996.\n[23] L.I.B. Silva, F.D.P. Ferreira, A.C. Freitas, T.A.P. Rocha-Santos, A.C.\nDuarte, \"Optical fiber-based micro-analyzer for indirect measurements\nof volatile amines levels in fish\". Food Chem., vol. 123, p. 806\u2013813,\n2010.\n[24] L.I.B. Silva, D. Rodrigues, A.C. Freitas, A.M. Gomes, T.A.P. Rocha-\nSantos, M.E. Pereira, A.C. Duarte, \"Optical fibre based methodology for\nscreening the effect of probiotic bacteria on conjugated linoleic acid\n(CLA) in curdled milk\". Food Chem., vol. 127, p. 222-227, 2011.\n[25] L.I.B. Silva, F.D.P. Ferreira, A.C. Freitas, T.A.P. Rocha-Santos, A.C.\nDuarte, \"Optical fiber biosensor coupled to chromatographic separation\nfor screening of dopamine, norepinephrine and epinephrine in human\nurine and plasma\", Talanta, vol. 80, p. 853-857, 2009.\n[26] F.D.P. Ferreira, L.I.B. Silva, A.C. Freitas, T.A.P. Rocha-Santos, A.C.\nDuarte, \"High performance liquid chromatography coupled to an optical\nfibre detector coated with laccase for screening catecholamines in\nplasma and urine\". J. Chromatography A., vol. 1216, p. 7049-7054,\n2009.\n[27] C.I.L. Justino, T.A.P. Rocha-Santos, A.C. Duarte, \"Review of analytical\nfigures of merit of sensors and biosensors in clinical applications\",\nTrends Anal. Chem., vol. 29, p. 1172-1183, 2010.\n[28] L.I.B. Silva, A.C. Freitas, T.A.P. Rocha-Santos, M.E. Pereira, A.C.\nDuarte, \"Breath analysis by optical fiber sensor for the determination of\nexhaled organic compounds with a view to diagnostics\". Talanta, vol.\n83, p. 1586-1594, 2011.\n[29] L.I.B. Silva, A.M. Gomes, M.M. Pintado, H. Pinheiro, D. Moura, A.C.\nFreitas, T.A.P. Rocha-Santos, M.E. Pereira, A.C. Duarte, \"Optical fiber\nbio-analyzer based on enzymatic coating matrix for catecholamines and\ntheir metabolites assessment in patients with Down syndrome\". IEEE\nSensors J., vol. 12, p. 76-84, 2012." } ], "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Carbon nanotubes field effect transistors" }, { "subject": "cardiovascular diseases" }, { "subject": "C-reactive protein" }, { "subject": "sensor." } ], "title": "Overview of CARDIOSENSOR Project on the Development of a Nanosensor for Assessing the Risk of Cardiovascular Disease", "version": "5490" }, "parent": { "access": { "owned_by": { "user": 32148 } }, "communities": { "default": "a59dd046-9a86-4a47-97ce-b51f1bb8fc3f", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2017-05-31T21:24:26.028360+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "a59dd046-9a86-4a47-97ce-b51f1bb8fc3f", "links": {}, "metadata": { "curation_policy": "", "description": "", "page": "", "title": "World Academy of Science, Engineering and Technology" }, "revision_id": 0, "slug": "waset", "updated": "2017-11-15T12:37:31.935319+00:00" } ], "ids": [ "a59dd046-9a86-4a47-97ce-b51f1bb8fc3f" ] }, "id": "1061145", "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.1061145", "provider": "datacite" } } }, "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.1061146", "provider": "datacite" }, "oai": { "identifier": "oai:zenodo.org:1061146", "provider": "oai" } }, "revision_id": 7, "stats": { "all_versions": { "data_volume": 18899967.0, "downloads": 29, "unique_downloads": 26, "unique_views": 131, "views": 216 }, "this_version": { "data_volume": 18899967.0, "downloads": 29, "unique_downloads": 26, "unique_views": 131, "views": 216 } }, "status": "published", "updated": "2020-01-20T13:36:14.494207+00:00", "versions": { "index": 1, "is_latest": true } }