Journal article Open Access

Metabolism and physiological effects of carbon dioxide. Implications in anaesthetic management

Rusu, Victoria

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    <subfield code="u">Valeriu Ghereg Department of Anesthesiology and Reanimatology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova</subfield>
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    <subfield code="a">&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Carbon dioxide is a normal by-product of aerobic metabolism that maintains the equilibrium of respiratory act, being eliminated fromthe lungs. Despite of an increasing number of researches concerning carbon dioxide metabolism and its effects on human homeostasis, there are stilldiscussions about carbon dioxide metabolism, physiology and its implication in anaesthetic management, ICU, critically ill patient. The use of mild tomoderate hypercapnia during general anaesthesia and in mechanically ventilated patients is growing, based on scientifical researches of last years.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;There has been scientifically evaluated data from PubMed, 2002-2017. Key words used in search are: &amp;ldquo;carbon dioxide&amp;rdquo;, &amp;ldquo;ventilation&amp;rdquo;,&amp;ldquo;metabolism&amp;rdquo;, &amp;ldquo;gas change&amp;rdquo;. There were selected articles, taking in consideration their title, and chosen abstracts. The article contains a qualitative analysisand synthesis of the recommendation, concerning anaesthetic management and metabolism of carbon dioxide.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Carbon dioxide metabolism and its anaesthetic management, represents a challenge that will be actual for many years in future. The amountof controversial studies about effects of carbon dioxide on patients under general anaesthesia or mechanical ventilation, determined us to perform areview of literature, and evaluate it.There are known facts about carbon dioxide metabolism, such as normal values, how it is produced in human body, how it is evacuated, effects on cardiovascular,nervous systems, and still there are many controversial studies on that topic, that determine to study it more and find new research results.&lt;/p&gt;</subfield>
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