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Background: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic section, oxidation-reduction reactions, endothelium, and vascular smooth muscle cells and is associated with an increased risk of adverse outcomes in pregnancy.
\nMaterials and methods: The study included 50 women who had experienced the loss of at least two consecutive pregnancies. The level of the total serum homocysteine was measured via the chemiluminescent method.
\nResults: We found that plasma homocysteine concentration < 10 μmol/l was found in 16 patients (32,0%, 95% CI 19,07 – 44,93), 9 patients (18.0%, 95% CI 7,36 – 28,64) had a fasting plasma homocysteine between 10 μmol/l to 12 μmol/l and 25 patients (50.0%, 95%CI 36,15 – 63,85) had significantly high total serum homocysteine values. Among them, 23 patients (46.0%, 95%CI 32,19 – 59,81) had the concentration between 12 – 30 μmol/l and 2 patients (4,0%, 95%CI -1,43 – 9,43) had the concentration > 30μmol/l. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception. In the current study, 40 women (80.0%, 95% CI 68,92 – 91,08) have become pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy.
\nConclusions: The prevalence of hyperhomocysteinemia was more in unexplained primary early recurrent miscarriages. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception and 40 women (80.0%, 95% CI 68,92 – 91,08) became pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy.
The Moldovan Medical Journal is an international scientific double-blind peer reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine and public health. From its debut the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development.
\r\n\r\nThe Editorial Board warmly welcomes both the readers of and the authors for the journal, all those who are enthusiastic in searching new and more effective ways of solving numerous medicine problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging.
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The Moldovan Medical Journal supports the Open Access policy. There are no fees to access the published articles. All the content of the journal is available on our web page in PDF immediately upon publication according to the Budapest, Berlin and Bethesda Open Access Initiative’s definition of Open Access. In the Republic of Moldova, the State policy in the field of sciences is based on the Code on Science and Innovation, adopted in 2004, which provides the guaranteed access to scientific information.
\r\n\r\nThe journal has no article processing or submission charges and no author’s emoluments. Publication of the journal is supported by the academic and scientific institutions of the Republic of Moldova: Nicolae Testemitsanu State University of Medicine and Pharmacy, Medial Department of Academy of Sciences, Institute of Mother and Child, Institute of Oncology, Institute of Cardiology, Institute of Neurology and Neurosurgery, Chiril Draganiuc Institute of Phthisiopneumology, Institute of Urgent Medicine, National Center of Public Health.
\r\n\r\nPublication of the journal is favored by the Council of Experts of the Ministry of Health of the Republic of Moldova.
\r\n\r\nArticles are accepted for consideration regardless of nationality, gender, race, and sexual orientation, ethical, religious and political beliefs of the authors.
\r\n\r\nEthics and malpractice guidelines of our journal are based on the Code of Conduct and Best Practice Guidelines for Journal Editors made up by the Committee on Publication Ethics (www.publicationethics.org), on the Uniform Requirements for Manuscripts Submitted to Biomedical Journals developed by the International Committee of Medical Journal Editors (www.icmje.org), on the principles of the World Association of Medical Editors (www.wame.org) and on the standards of the National Ethics Committee (www.ms.gov.md) of the Republic of Moldova. The journal tends to become the member of and subscribes to the principles of the Committee of Publication Ethics (COPE).
\r\n\r\nThe journal is indexed in the State Scientific Medical Library of the Russian Federation, in the database VINITI (Vserossiiskiy Institut Nauchnoy i Tekhnicheskoi Informatsii) [All-Russian Scientific and Technical Information Institute] and being listed in Ulrichsweb Global Serials Directory.
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