August 30, 2017 Journal article Open Access

Benzil Dudekula1*, Dr.C.Ramachandraiah2, Dr.N.Devanna3

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{
  "description": "<p>Analytical method was developed for the estimation of Sofosbuvir and Daclatasvir drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Acetonitrile (60:40). The flow rate was 1.0 ml/ minute and ultra violet detector at 275nm. The average retention time for Sofosbuvir and Daclatasvir found to be 2.09 and 3.50 min. The proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were within the acceptable range. The assay methods were found to be linear from 80-240 \u03bcg/ml for Sofosbuvir and 12-36\u03bcg/ml for Daclatasvir.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "1S.V.Engineering college for women, Tirupati-517507, Chittor (Dt). 2SKIT, Srikalahasthi-517640. 3Jawaharlal Nehru Technological University Anantapur, College of Engineering, Anantapur-515002, Andhra Pradesh.", 
      "@type": "Person", 
      "name": "Benzil Dudekula1*, Dr.C.Ramachandraiah2, Dr.N.Devanna3"
    }
  ], 
  "headline": "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DRUG PRODUCT BY RP-HPLC METHOD", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2017-08-30", 
  "url": "https://zenodo.org/record/1036476", 
  "keywords": [
    "Sofosbuvir And Daclatasvir, Isocratic, HPLC, C18, Trifluoro Acetic Acid, Methanol, Acetonitrile And Validation."
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.1036476", 
  "@id": "https://doi.org/10.5281/zenodo.1036476", 
  "@type": "ScholarlyArticle", 
  "name": "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DRUG PRODUCT BY RP-HPLC METHOD"
}