1036472
doi
10.5281/zenodo.1036472
oai:zenodo.org:1036472
user-iajpr
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LEVONORGESTREL
Balasaheb B. Karad*, Dr. Ajay D. Shinde
Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandal's College of Pharmacy, Malegaon(Bk), Baramati, Dist. Pune Maharashtra, India 413115.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Levonorgestrel, Immediate Release, Superdisintegrants, Direct Compression.
<p>The study was undertaken with an aim to develop and optimized formulation of Hormonal contraceptive, Levonorgestrel by oral drug delivery. Pre-formulation studies were conducted to know the drug excipient compatibilities. The superdisintegrants crospovidone and sodium starch glycolate were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipient interaction was investigated by FTIR. All formulation showed compliances with the pharmacopoeial standard. The study reveals that formulations prepared by direct compression F9 exhibits highest dissolution using both crospovidone and SSG showed faster drug release 93.13 % over the period of 60 min while disintegration time of the tablet was showed 45 sec comparison to other formulations of Levonorgestrel. The objective of the present project was successfully achieved by developing the product, giving the same release profile to that of innovators product. From this study we are conclude that the immediate release tablet of Levonorgestrel can be formulate and it shows better drug release response.</p>
Zenodo
2017-08-30
info:eu-repo/semantics/article
1036471
user-iajpr
1579540724.682659
821221
md5:ff3588bd601a4a77afe1701e625c0a3d
https://zenodo.org/records/1036472/files/10.pdf
public
10.5281/zenodo.1036471
isVersionOf
doi
INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH
07
09
471-479
2017-08-30