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FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LEVONORGESTREL

Balasaheb B. Karad*, Dr. Ajay D. Shinde


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    "description": "<p>The study was undertaken with an aim to develop and optimized formulation of Hormonal contraceptive, Levonorgestrel by oral drug delivery. Pre-formulation studies were conducted to know the drug excipient compatibilities. The superdisintegrants crospovidone and sodium starch glycolate were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipient interaction was investigated by FTIR. All formulation showed compliances with the pharmacopoeial standard. The study reveals that formulations prepared by direct compression F9 exhibits highest dissolution using both crospovidone and SSG showed faster drug release 93.13 % over the period of 60 min while disintegration time of the tablet was showed 45 sec comparison to other formulations of Levonorgestrel. The objective of the present project was successfully achieved by developing the product, giving the same release profile to that of innovators product. From this study we are conclude that the immediate release tablet of Levonorgestrel can be formulate and it shows better drug release response.</p>", 
    "license": {
      "id": "CC-BY-4.0"
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    "title": "FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LEVONORGESTREL", 
    "journal": {
      "volume": "07", 
      "issue": "09", 
      "pages": "471-479", 
      "title": "INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH"
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    "keywords": [
      "Levonorgestrel, Immediate Release, Superdisintegrants, Direct Compression."
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    "publication_date": "2017-08-30", 
    "creators": [
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        "affiliation": "Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandal's College of Pharmacy, Malegaon(Bk), Baramati, Dist. Pune Maharashtra, India 413115.", 
        "name": "Balasaheb B. Karad*, Dr. Ajay D. Shinde"
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