26806347 3 - 688,689 AR 543,545 - AR null 367 Chemical Gene +|conj|START_ENTITY status|dep|+ performed|dobj|status performed|advcl|assess assess|dobj|role role|nmod|END_ENTITY To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples . 26806347 3 - 688,689 AR 659,661 - AR null 367 Chemical Gene +|conj|START_ENTITY status|dep|+ status|amod|signaling signaling|nmod|analysis analysis|nmod|samples samples|amod|stratified stratified|nmod|END_ENTITY To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples . 26806347 3 - 688,689 AR 750,752 - AR null 367 Chemical Gene +|conj|START_ENTITY status|dep|+ status|acl:relcl|identified identified|nmod|samples samples|amod|increased increased|nmod|END_ENTITY To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples . 2347471 7 - 1258,1259 CD16 1233,1237 - CD16 null 2214 Chemical Gene Leu7|conj|START_ENTITY END_ENTITY|conj|Leu7 In contrast , the population of activated natural killer cells -LRB- CD16 -LRB- + -RRB- and Leu7 -LRB- + -RRB- or -LRB- - -RRB- -RRB- remained below 4 % for the entire period of culture . 25893674 4 - 892,893 Cd38 806,810 - Cd38 null 12494(Tax:10090) Chemical Gene START_ENTITY|appos|- APP.PS.Cd38|dobj|- mice|dep|APP.PS.Cd38 mice|nmod|END_ENTITY METHODS : We crossed APPswePS1 E9 -LRB- APP.PS -RRB- mice with Cd38 -LRB- - -RRB- -LRB- / -RRB- -LRB- - -RRB- mice to generate AD-prone CD38-deficient animals -LRB- APP.PS.Cd38 -LRB- - -RRB- -LRB- / -RRB- -LRB- - -RRB- -RRB- and examined AD-related phenotypes in both groups . 24416664 5 - 570,571 CIM 653,656 - CIM null 27248 Chemical Gene START_ENTITY|acl:relcl|show show|ccomp|% %|nsubj|expenditures expenditures|nmod|END_ENTITY -LRB- 1 -RRB- -LRB- - -RRB- -LRB- 4 -RRB- The most recent estimates show that total US out-of-pocket expenditures for CIM were 34 billion-11 % of all US out-of-pocket healthcare expenditures . 27956676 10 - 1581,1582 fibrinogen 1439,1449 - fibrinogen null 2244 Chemical Gene dL|appos|START_ENTITY h|dep|dL difference|nmod|h admission|nmod|difference remained|nmod|admission remained|nsubj|concentrations concentrations|compound|END_ENTITY Plasma fibrinogen concentrations remained higher in the FC group up to 12 h after admission with the largest difference at three h -LRB- 2.9 mg dL -LRB- - -RRB- -LRB- 1 -RRB- vs. 1.8 mg dL -LRB- - -RRB- -LRB- 1 -RRB- ; P < 0.01 -RRB- . 21153135 5 - 1067,1068 hCG 1034,1037 - hCG null 3342 Chemical Gene END_ENTITY|appos|START_ENTITY Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- . 21153135 5 - 1067,1068 hCG 1039,1042 - hCG null 3342 Chemical Gene hCG|appos|START_ENTITY END_ENTITY|conj|hCG Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- . 21153135 5 - 1067,1068 hCG 962,965 - hCG null 3342 Chemical Gene hCG|appos|START_ENTITY stimulated|nmod|hCG cyclase|acl|stimulated desensitization|nmod|cyclase leads|nmod|desensitization leads|nsubj|treatment treatment|nmod|cells cells|nmod|PMA PMA|conj|END_ENTITY Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- . 25640386 11 - 1624,1625 hormone_receptor 1598,1614 - hormone receptor null 3164 Chemical Gene sensitivity|appos|START_ENTITY sensitivity|nmod|END_ENTITY Similarly 18F-FDG-PET/CT had higher sensitivity and specificity in hormone_receptor -LRB- + -RRB- and -LRB- - -RRB- groups . 2347471 7 - 1258,1259 Leu7 1245,1249 - Leu7 null 27087 Chemical Gene END_ENTITY|conj|START_ENTITY In contrast , the population of activated natural killer cells -LRB- CD16 -LRB- + -RRB- and Leu7 -LRB- + -RRB- or -LRB- - -RRB- -RRB- remained below 4 % for the entire period of culture . 24744983 5 - 761,762 mTOR 888,892 - mTOR null 2475 Chemical Gene 8|dep|START_ENTITY include|dep|8 include|dobj|genes genes|acl|involved involved|nmod|signaling signaling|conj|pathways pathways|compound|END_ENTITY -LRB- 8 -RRB- -LRB- - -RRB- -LRB- 13 -RRB- These networks include genes involved in insulin-like signaling , the heat_shock response , the response to hypoxia , and mTOR and AMPK pathways linked to aging . 27490171 8 - 1512,1513 NTf2 1506,1510 - NTf2 null 10204 Chemical Gene MsO|appos|START_ENTITY MsO|amod|END_ENTITY The order is found to be as follows : SbF6 -LRB- - -RRB- < BF4 -LRB- - -RRB- < NTf2 -LRB- - -RRB- > ClO4 _ -LRB- - -RRB- > FSO3 _ -LRB- - -RRB- < TfO -LRB- - -RRB- < HSO4 _ -LRB- - -RRB- < Cl -LRB- - -RRB- < MsO -LRB- - -RRB- . 27015986 5 - 944,945 p57 987,990 - p57 null 12721(Tax:10090) Chemical Gene inhibition|appos|START_ENTITY inhibition|appos|only only|acl|defined defined|dobj|function function|nmod|END_ENTITY To test this possibility , we generated knock-in mice deficient for p57-mediated cyclin-CDK inhibition -LRB- p57 -LRB- CK -RRB- _ -LRB- - -RRB- -RRB- , the only clearly defined function of p57 . 24778766 5 - 726,727 PTEN 776,780 - PTEN null 5728 Chemical Gene START_ENTITY|acl:relcl|Understanding Understanding|dobj|mechanisms mechanisms|acl:relcl|modulates modulates|nsubj|END_ENTITY -LRB- 1 -RRB- -LRB- - -RRB- -LRB- 9 -RRB- Understanding the mechanisms through which PTEN modulates the structure , function , and plasticity of cortical networks is a major focus of study . 1765100 0 + 29,30 ATP-citrate_lyase 87,104 + ATP-citrate lyase null 24159(Tax:10116) Chemical Gene Synthesis|nmod|START_ENTITY Synthesis|dep|difluorocitrate difluorocitrate|nmod|inhibitors inhibitors|nmod|END_ENTITY Synthesis and evaluation of -LRB- + -RRB- and -LRB- - -RRB- -2,2 - difluorocitrate as inhibitors of rat-liver ATP-citrate_lyase and porcine-heart aconitase . 27766923 0 + 105,106 beta_amyloid_peptide 138,158 + beta amyloid peptide null 351 Chemical Gene compound|appos|START_ENTITY mucronata|conj|compound antiaggregation|nmod|mucronata catechin|nmod|antiaggregation catechin|nmod|END_ENTITY In vitro antiaggregation and deaggregation potential of Rhizophora mucronata and its bioactive compound -LRB- + -RRB- - catechin against Alzheimer 's beta_amyloid_peptide -LRB- 25-35 -RRB- . 23996432 1 + 279,280 BRAF 217,221 + BRAF null 673 Chemical Gene investigated|dep|START_ENTITY investigated|dobj|values values|nmod|END_ENTITY We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients . 28560459 4 + 1367,1368 ERK 1204,1207 + ERK null 5594 Chemical Gene treated|nsubj|START_ENTITY analysis|acl:relcl|treated detected|nmod|analysis detected|nsubjpass|phosphorylation phosphorylation|dep|kinase kinase|appos|END_ENTITY The phosphorylation of extracellular signal - regulated kinase -LRB- ERK -RRB- , an important downstream protein of the InsR - mitogen - activated protein kinases -LRB- MAPK -RRB- signaling pathway , was also detected by western blot analysis when -LRB- + -RRB- - PTZ and BD __ -1063 were added to the 80 mmHg - treated cells . 28560459 8 + 1726,1727 ERK 1856,1859 + ERK null 5594 Chemical Gene decreased|dep|START_ENTITY decreased|conj|increased increased|dobj|R R|conj|phosphorylation phosphorylation|nmod|END_ENTITY -LRB- + -RRB- - PTZ decreased the apoptosis and death of hTMCs and increased the expression of Sig __ -1 R and InsR , and the phosphorylation of ERK . 28560459 10 + 1952,1953 InsR 2037,2041 + InsR null 3643 Chemical Gene agonist|appos|START_ENTITY induced|nsubj|agonist induced|advcl|activating activating|dobj|END_ENTITY The present study suggested that Sig __ -1 R agonist -LRB- + -RRB- - PTZ can protect hTMCs from pressure - induced apoptosis and death by activating InsR and the MAPK signal pathway . 28560459 4 + 1367,1368 InsR 1249,1253 + InsR null 3643 Chemical Gene treated|nsubj|START_ENTITY analysis|acl:relcl|treated detected|nmod|analysis detected|nsubjpass|phosphorylation phosphorylation|dep|kinase kinase|appos|protein protein|nmod|END_ENTITY The phosphorylation of extracellular signal - regulated kinase -LRB- ERK -RRB- , an important downstream protein of the InsR - mitogen - activated protein kinases -LRB- MAPK -RRB- signaling pathway , was also detected by western blot analysis when -LRB- + -RRB- - PTZ and BD __ -1063 were added to the 80 mmHg - treated cells . 28560459 8 + 1726,1727 InsR 1823,1827 + InsR null 3643 Chemical Gene decreased|dep|START_ENTITY decreased|conj|increased increased|dobj|R R|conj|END_ENTITY -LRB- + -RRB- - PTZ decreased the apoptosis and death of hTMCs and increased the expression of Sig __ -1 R and InsR , and the phosphorylation of ERK . 23996432 1 + 279,280 KRAS 263,267 + KRAS null 3845 Chemical Gene investigated|dep|START_ENTITY investigated|dobj|values values|nmod|responses responses|nmod|wild-type wild-type|compound|END_ENTITY We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients . 23996432 1 + 279,280 PI3K 223,227 + PI3K null 5293 Chemical Gene investigated|dep|START_ENTITY investigated|dobj|values values|nmod|BRAF BRAF|conj|END_ENTITY We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients . 23996432 1 + 279,280 PTEN 232,236 + PTEN null 5728 Chemical Gene investigated|dep|START_ENTITY investigated|dobj|values values|nmod|BRAF BRAF|conj|END_ENTITY We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients . 28560459 1 + 244,245 Sig-1R 227,233 + Sig-1R null 10280 Chemical Gene agonist|appos|START_ENTITY agonist|compound|receptor receptor|appos|END_ENTITY The purpose of the present study was to investigate the protective effect of the -1 receptor -LRB- Sig-1R -RRB- agonist -LRB- + -RRB- - pentazocin -LRB- PTZ -RRB- on pressure-induced apoptosis and death of human trabecular meshwork cells -LRB- hTMCs -RRB- . 8836928 2 + 281,282 sigma_1_receptor 309,325 + sigma 1 receptor null 29336(Tax:10116) Chemical Gene -LSB-|appos|START_ENTITY -LSB-|dep|END_ENTITY Acute administration of -LRB- + -RRB- - N-allylnormetazocine -LSB- -LRB- + -RRB- - SKF-10 ,047 -RSB- , a prototype sigma_1_receptor ligand , and 1,3-di -LRB- 2-tolyl -RRB- guanidine -LRB- DTG -RRB- , a non-specific sigma receptor ligand , increased the extracellular ACh level in the rat hippocampus . 20173184 7 0055Leu-Ala0096 947,962 B1-1 914,918 0055Leu-Ala0096 B1-1 MESH:C026526 931 Chemical Gene B1-2|dep|START_ENTITY END_ENTITY|conj|B1-2 Region 1 peptides , B1-1 -LRB- 0014Lys-Glu0054 -RRB- and B1-2 -LRB- 0055Leu-Ala0096 -RRB- , mediate transfection of HeLa cells but are cytotoxic . 20173184 7 0055Leu-Ala0096 947,962 B1-2 941,945 0055Leu-Ala0096 B1-2 MESH:C026526 4709;931;28907 Chemical Gene END_ENTITY|dep|START_ENTITY Region 1 peptides , B1-1 -LRB- 0014Lys-Glu0054 -RRB- and B1-2 -LRB- 0055Leu-Ala0096 -RRB- , mediate transfection of HeLa cells but are cytotoxic . 20812894 8 01CM53122 1498,1507 env 1515,1518 01CM53122 env null 30816 Chemical Gene START_ENTITY|nmod|region region|compound|END_ENTITY Further analysis of the 01CM53122 genome showed that this virus represents a diverse set of mosaic genomes from CRF22_01A1 , including a 446-nt segment of 01CM53122 in the env region , but unlike other CRF22 strains , clustered with CRF01_AE rather than the A1 sequence , suggesting that the 01CM53122 strain is a recombinant of CRF22_01A1 and CRF01_AE . 15618722 5 021125Fujieda007 1050,1066 CYP2A13 1079,1086 021125Fujieda007 CYP2A13 null 1553 Chemical Gene SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY SNP , 021125Fujieda007 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - AGTTCAGCGGGCG/AAGGCGAGCAGGC -3 ' . 15618722 7 021125Fujieda017 1296,1312 CYP2A13 1325,1332 021125Fujieda017 CYP2A13 null 1553 Chemical Gene SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY SNP , 021125Fujieda017 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - TCTTTCTCTTCTT/ACACCACCATCAT -3 ' . 15618722 8 021125Fujieda018 1419,1435 CYP2A13 1448,1455 021125Fujieda018 CYP2A13 null 1553 Chemical Gene SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY SNP , 021125Fujieda018 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - AGCTTCCTGCCCC/TGCTGAGCGAGGG -3 ' . 11261925 5 0214/02142 785,795 HLA-A 779,784 0214/02142 HLA-A MESH:C423265 3105 Chemical Gene elution|dep|START_ENTITY determined|nmod|elution determined|dobj|motif motif|nmod|END_ENTITY We have determined the peptide-binding motif of HLA-A * 0214/02142 by peptide elution and bulk Edman degradative sequencing . 1690769 2 0249F 296,301 CD1b 316,320 0249F CD1b null 910 Chemical Gene START_ENTITY|conj|END_ENTITY Both 0249F and NU-T2 two CD1b specific mAb tested , induced a rapid increase in the intracellular Ca2 + concentration on HPBALL T cells whereas only one -LRB- L161 -RRB- among three different CD1c mAb -LRB- L161 , 10C3 , and M241 -RRB- produced a similar effect . 1690769 2 0249F 296,301 CD1c 471,475 0249F CD1c null 911 Chemical Gene START_ENTITY|acl:relcl|tested tested|dep|induced induced|advcl|mAb mAb|nsubj|one one|nmod|END_ENTITY Both 0249F and NU-T2 two CD1b specific mAb tested , induced a rapid increase in the intracellular Ca2 + concentration on HPBALL T cells whereas only one -LRB- L161 -RRB- among three different CD1c mAb -LRB- L161 , 10C3 , and M241 -RRB- produced a similar effect . 16547398 5 050824FujitaK001 520,536 UGT1A9 549,555 050824FujitaK001 UGT1A9 MESH:D011188 54600 Chemical Gene SNP|appos|START_ENTITY SNP|dep|Name Name|appos|END_ENTITY The sequence is as follows : SNP , 050824FujitaK001 ; Gene Name , UGT1A9 ; Accession Number , AF297093 ; Length , 25 bases ; 5 ' - CCTTCTTGAAGAT/CATGTATTTATAA -3 ' . 16547397 5 050824FujitaK002 380,396 UGT1A7 409,415 050824FujitaK002 UGT1A7 MESH:D011188 54577 Chemical Gene SNP|appos|START_ENTITY SNP|dep|Name Name|appos|END_ENTITY The sequence is as follows : SNP , 050824FujitaK002 ; Gene Name , UGT1A7 ; Accession Number , AF297093 ; Length , 25 bases ; 5 ' - TAAAGGAGAGTTG/CTTTTGATGCAGT -3 ' . 14564379 6 0-5-10-15_cmH2O 689,704 CPAP 676,680 0-5-10-15 cmH2O CPAP null 55835 Chemical Gene levels|dep|START_ENTITY levels|amod|END_ENTITY Three gas flow rates -LRB- 20-30-40 l/min and 30-45-60 l/min , respectively , for CPAPM and CPAPH -RRB- and four CPAP levels -LRB- 0-5-10-15_cmH2O -RRB- were employed in a randomized sequence . 20657724 5 0524KO 1474,1480 PGN_0524 1535,1543 0524KO PGN_0524 MESH:C518174 6329742(Tax:431947) Chemical Gene strain|amod|START_ENTITY strain|acl:relcl|bears bears|dobj|deletion deletion|nmod|locus locus|nummod|END_ENTITY The resulting mutant strain , designated 0524-Tn4400 ' , was highly sensitive to PMB killing relative to wild-type P. _ gingivalis , and exhibited the same sensitivity as the previously characterized strain , 0524KO , which bears a genetically engineered deletion in the PGN_0524 locus . 17533713 10 05DJ14006 1449,1458 Y0203 1566,1571 05DJ14006 Y0203 null 1145150(Tax:187410) Chemical Gene No.|nummod|START_ENTITY Municipality|dep|No. Commission|nmod|Municipality Foundation|conj|Commission Foundation|conj|Grant Grant|nmod|Committee Committee|dep|No. No.|appos|END_ENTITY Supported by National Natural Science Foundation of China -LRB- Grant No. 30400502 -RRB- , Science and Technology Commission of Shanghai Municipality -LRB- Grant No. 04dz05601 , 05DJ14006 , 055407034 , 05QMoX14o6 -RRB- and Research Grant from Shanghai Education Committee -LRB- Grant No. 03BC39 , 04YQHB081 , Y0203 -RRB- . 17329912 4 060825Shimizu004 856,872 FMO3 885,889 060825Shimizu004 FMO3 null 2328 Chemical Gene follows|parataxis|START_ENTITY follows|parataxis|TATCCAGTGTAAA/GTAAACATCCTGA TATCCAGTGTAAA/GTAAACATCCTGA|nsubj|NAME NAME|appos|END_ENTITY These sequences are as follows : 1 -RRB- SNP , 060825Shimizu004 ; GENE NAME , FMO3 ; ACCESSION NUMBER , AL021026 ; LENGTH , 25 base ; 5 ' - TATCCAGTGTAAA/GTAAACATCCTGA -3 ' . 17329912 6 060825Shimizu006 1102,1118 FMO3 1131,1135 060825Shimizu006 FMO3 null 2328 Chemical Gene START_ENTITY|dep|NAME NAME|appos|END_ENTITY 3 -RRB- SNP , 060825Shimizu006 ; GENE NAME , FMO3 ; ACCESSION NUMBER , AL021026 ; LENGTH , 25 base ; 5 ' - TGTAGTCCCTACC/TAGTTTAGGCTGG -3 ' . 26475632 4 0-6-methylguanine 778,795 b-catenin 764,773 0-6-methylguanine b-catenin null 1499 Chemical Gene END_ENTITY|conj|START_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 BRAF 658,662 0-6-methylguanine BRAF null 673 Chemical Gene b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin immunostained|nmod|methyltransferase examined|conj|immunostained examined|nmod|mutations mutations|compound|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 KRAS 667,671 0-6-methylguanine KRAS null 3845 Chemical Gene b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin immunostained|nmod|methyltransferase examined|conj|immunostained examined|nmod|mutations mutations|compound|BRAF BRAF|conj|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 MGMT 819,823 0-6-methylguanine MGMT null 4255 Chemical Gene b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin methyltransferase|appos|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 MLH1 748,752 0-6-methylguanine MLH1 null 4292 Chemical Gene b-catenin|conj|START_ENTITY b-catenin|compound|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 p16 759,762 0-6-methylguanine p16 null 1029 Chemical Gene b-catenin|conj|START_ENTITY b-catenin|conj|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 26475632 4 0-6-methylguanine 778,795 p53 754,757 0-6-methylguanine p53 null 7157 Chemical Gene b-catenin|conj|START_ENTITY b-catenin|conj|END_ENTITY Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- . 21473113 8 06-methylguanine 1170,1186 MMR 1190,1193 06-methylguanine MMR null 50771(Tax:10090) Chemical Gene START_ENTITY|nmod|END_ENTITY DNA ds-breakes appeared downstream ss-breakes were attributed to repair of 06-methylguanine by MMR mechanism in PHA-stimulated lymphocytes . 23144384 2 08BA02176 513,522 S0385 648,653 08BA02176 S0385 null 1076824(Tax:198215) Chemical Gene isolate|appos|START_ENTITY sequence|nmod|isolate acquired|nsubjpass|sequence acquired|nmod|genome genome|nmod|isolate isolate|appos|END_ENTITY In this study , the complete genome sequence of a Canadian representative LA-MRSA isolate -LRB- 08BA02176 -RRB- from a human postoperative surgical site infection was acquired and compared to the sequenced genome of an LA-MRSA isolate -LRB- S0385 -RRB- from Europe to identify genetic traits that may explain differences in the success of these particular strains in some locales . 25374426 9 08-IMC 1256,1262 CCR5 1297,1301 08-IMC CCR5 null 1234 Chemical Gene infect|nsubj|START_ENTITY infect|dep|expressing expressing|dobj|END_ENTITY 08-IMC could infect the cells expressing CCR5 and be replicated in the CCR5-expressing cells with a positive percentage of 24.3 % , 08-ISO may use CCR5-using macrophage-tropic isolates as coreceptor , while pNL4-3 viruses with T cell tropisms utilize the CXCR4 co-receptor . 25374426 9 08-IMC 1256,1262 CXCR4 1510,1515 08-IMC CXCR4 null 7852 Chemical Gene infect|nsubj|START_ENTITY use|ccomp|infect use|advcl|utilize utilize|dobj|co-receptor co-receptor|compound|END_ENTITY 08-IMC could infect the cells expressing CCR5 and be replicated in the CCR5-expressing cells with a positive percentage of 24.3 % , 08-ISO may use CCR5-using macrophage-tropic isolates as coreceptor , while pNL4-3 viruses with T cell tropisms utilize the CXCR4 co-receptor . 25374426 5 08-IMC 759,765 p24 731,734 08-IMC p24 null 10959 Chemical Gene generated|nmod|START_ENTITY antigens|acl|generated antigens|amod|END_ENTITY HIV-1 p24 antigens generated from 08-IMC were slightly greater than those from infectious molecular clones pNL4-3 3 and 93JP-NH1 , but without statistical difference -LRB- all P > 0.05 -RRB- . 18162524 7 0900-0900 1214,1223 leptin 1167,1173 0900-0900 leptin MESH:C523421 443534(Tax:9940) Chemical Gene infusion|appos|START_ENTITY infusion|nmod|ventricle ventricle|nmod|vehicle vehicle|conj|END_ENTITY Intracerebroventricular infusion into the lateral ventricle of either vehicle -LRB- artificial cerebrospinal fluid -RRB- or leptin -LRB- 10 microg/h at 100 microl/h -RRB- for 24 h -LRB- 0900-0900 -RRB- was performed in a cross-over design with a 1-wk recovery period between treatments . 26923241 1 0CHCH2 221,227 CF2 213,216 0CHCH2 CF2 null 537 Chemical Gene >|ccomp|START_ENTITY x|acl|> CF3|dep|x CF3|appos|END_ENTITY Hydrofluoroolefins -LRB- HFOs -RRB- of the type CF3 -LRB- CF2 -RRB- x > = 0CHCH2 , are currently being suggested as substitutes of some hydrofluorocarbons -LRB- HFCs -RRB- . 6145159 5 0-diazo-acetyl-L-serine 689,712 glutamine_synthetase 962,982 0-diazo-acetyl-L-serine glutamine synthetase null 14645(Tax:10090) Chemical Gene 6-diazo-5-oxo-L-norleucine|conj|START_ENTITY isoxazolidone|amod|6-diazo-5-oxo-L-norleucine inhibitors|appos|isoxazolidone protected|nsubj|inhibitors protected|advcl|exacerbated exacerbated|nsubj|pyridoxal-5 pyridoxal-5|appos|inhibitor inhibitor|amod|END_ENTITY Glutaminase inhibitors , 6-diazo-5-oxo-L-norleucine -LRB- DON -RRB- and 0-diazo-acetyl-L-serine -LRB- azaserine -RRB- , and a transaminase inhibitor , 4-amino-3 - _ isoxazolidone -LRB- L-cycloserine -RRB- , when injected intraperitoneally , protected the seizure-susceptible mouse from undergoing convulsions , whereas pyridoxal-5 ' - phosphate and methionine_sulphoximine , a glutamine_synthetase inhibitor , exacerbated its epileptic_condition . 1041590 4 0-nitrophenyl-beta-D-galactopyranoside 606,644 ornithine_decarboxylase 649,672 0-nitrophenyl-beta-D-galactopyranoside ornithine decarboxylase null 4953 Chemical Gene START_ENTITY|conj|END_ENTITY Two newly developed test strips , for 0-nitrophenyl-beta-D-galactopyranoside and ornithine_decarboxylase , were found to be highly reliable . 1238112 7 0-nitrophenyl-sulfenyl_chloride 1292,1323 phospholipase_A2 1223,1239 0-nitrophenyl-sulfenyl chloride phospholipase A2 null 5319 Chemical Gene using|xcomp|START_ENTITY sulfenylated|xcomp|using sulfenylated|nsubjpass|residue residue|nmod|END_ENTITY The single Trp10 residue in native phospholipase_A2 and its zymogen was specifically sulfenylated using 0-nitrophenyl-sulfenyl_chloride . 9018469 3 0OH 690,693 CO2 639,642 0OH CO2 null 717 Chemical Gene H2O2|conj|START_ENTITY H2O2|dep|acetate acetate|conj|END_ENTITY Data obtained indicate that consumption of H2O2 by pyruvate -LRB- generating acetate and CO2 via an oxidative decarboxylation reaction -RRB- and 0OH radical by lactate -LRB- generating pyruvate , and subsequently acetate and CO2 -RRB- may serve to protect alternative biofluid components -LRB- e.g. , macromolecules -RRB- against reactive oxygen species-mediated oxidative damage in vivo . 19833204 8 0S-2-3-4-5-6-7-8 1208,1224 ERalpha 1264,1271 0S-2-3-4-5-6-7-8 ERalpha null 24890(Tax:10116) Chemical Gene variants|appos|START_ENTITY variants|dep|proteins proteins|compound|END_ENTITY Moreover , we determined a splicing event to yield Deltaexon 1 variants -LRB- 0S-2-3-4-5-6-7-8 -RRB- , which are translated into rat 46 kDa ERalpha proteins . 20543109 6 1001-1013 821,830 IFN-beta 886,894 1001-1013 IFN-beta MESH:C013844 15977(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY increased|nsubj|pJAK2 increased|dobj|level level|nmod|END_ENTITY pJAK2 -LRB- 1001-1013 -RRB- increased the intracellular level of the constitutive IFN-beta , which may play a role in the antagonist antiviral effect at the cellular level . 17404288 10 1001-1013 1580,1589 IFN-gamma 1611,1620 1001-1013 IFN-gamma MESH:C013844 15978(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY pJAK2|dep|activity activity|amod|END_ENTITY Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation . 17404288 10 1001-1013 1580,1589 IFN-gamma 1722,1731 1001-1013 IFN-gamma MESH:C013844 15978(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY blocked|nsubj|pJAK2 blocked|nmod|cells cells|conj|activity activity|compound|END_ENTITY Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation . 20543109 8 1001-1013 1131,1140 IFN-gamma 1175,1184 1001-1013 IFN-gamma MESH:C013844 15978(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY synergizes|nsubj|pJAK2 synergizes|nmod|IFNs IFNs|nmod|mimetic mimetic|amod|END_ENTITY pJAK2 -LRB- 1001-1013 -RRB- also synergizes with IFNs as per IFN-gamma mimetic to exert a multiplicative antiviral effect at the level of transcription , the cell , and protection of mice against lethal viral_infection . 20543109 9 1001-1013 1338,1347 IFN-gamma 1456,1465 1001-1013 IFN-gamma MESH:C013844 15978(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|conj|blocks blocks|nmod|promoter promoter|amod|END_ENTITY pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter . 17404288 9 1001-1013 1483,1492 JAK2 1512,1516 1001-1013 JAK2 MESH:C013844 16452(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY binds|nmod|pJAK2 fact|dep|binds suggests|nsubj|fact suggests|ccomp|function function|nsubj|peptide peptide|compound|END_ENTITY The fact that SOCS1-KIR binds to pJAK2 -LRB- 1001-1013 -RRB- suggests that the JAK2 peptide could function as an antagonist of SOCS-1 . 17404288 9 1001-1013 1483,1492 SOCS-1 1560,1566 1001-1013 SOCS-1 MESH:C013844 12703(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY binds|nmod|pJAK2 fact|dep|binds suggests|nsubj|fact suggests|ccomp|function function|nmod|antagonist antagonist|nmod|END_ENTITY The fact that SOCS1-KIR binds to pJAK2 -LRB- 1001-1013 -RRB- suggests that the JAK2 peptide could function as an antagonist of SOCS-1 . 20543109 9 1001-1013 1338,1347 SOCS-1 1395,1401 1001-1013 SOCS-1 MESH:C013844 12703(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|nmod|region region|nmod|END_ENTITY pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter . 20543109 9 1001-1013 1338,1347 SOCS-3 1406,1412 1001-1013 SOCS-3 MESH:C013844 12702(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|nmod|region region|nmod|SOCS-1 SOCS-1|conj|END_ENTITY pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter . 17404288 10 1001-1013 1580,1589 STAT3 1668,1673 1001-1013 STAT3 MESH:C013844 20848(Tax:10090) Chemical Gene pJAK2|appos|START_ENTITY blocked|nsubj|pJAK2 blocked|dobj|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation . 9210654 10 10014-10018 1316,1327 P450 1380,1384 10014-10018 P450 MESH:C000192 1583 Chemical Gene USA|amod|START_ENTITY USA|nmod|activity activity|nmod|P450c27 P450c27|appos|END_ENTITY USA 91 , 10014-10018 -RRB- because this activity of P450c27 -LRB- 28 pmol/min/nmol P450 -RRB- seems far too low to be physiologically relevant . 9210654 10 10014-10018 1316,1327 P450c27 1354,1361 10014-10018 P450c27 MESH:C000192 301517(Tax:10116) Chemical Gene USA|amod|START_ENTITY USA|nmod|activity activity|nmod|END_ENTITY USA 91 , 10014-10018 -RRB- because this activity of P450c27 -LRB- 28 pmol/min/nmol P450 -RRB- seems far too low to be physiologically relevant . 1751497 11 10041-10047 2283,2294 PLA2 2379,2383 10041-10047 PLA2 MESH:C012134 104974671 Chemical Gene -RSB-|nummod|START_ENTITY -RSB-|dep|step step|nmod|catalysis catalysis|nmod|END_ENTITY 264 , 10041-10047 -RSB- that substrate-level acylation of Lys-56 is an obligatory step in the catalysis by PLA2 . 18156631 11 10042-10051 1352,1363 ADAMTS-4 1440,1448 10042-10051 ADAMTS-4 MESH:C098805 9507 Chemical Gene 279|amod|START_ENTITY 279|appos|investigation investigation|nmod|role role|nmod|domain domain|nmod|END_ENTITY 279 , 10042-10051 -RRB- , our detailed investigation of the role of the C-terminal spacer domain of ADAMTS-4 indicated that full-length ADAMTS-4 is approximately 20-times more active against aggrecan than its spacer domain deletion mutant , even at the Glu373-Ala374 site of the interglobular domain . 18156631 11 10042-10051 1352,1363 ADAMTS-4 1476,1484 10042-10051 ADAMTS-4 MESH:C098805 9507 Chemical Gene 279|amod|START_ENTITY indicated|nsubj|279 indicated|ccomp|20-times 20-times|nsubj|END_ENTITY 279 , 10042-10051 -RRB- , our detailed investigation of the role of the C-terminal spacer domain of ADAMTS-4 indicated that full-length ADAMTS-4 is approximately 20-times more active against aggrecan than its spacer domain deletion mutant , even at the Glu373-Ala374 site of the interglobular domain . 15625830 0 1004C 14,19 G6PD 26,30 1004C G6PD null 2539 Chemical Gene _|nummod|START_ENTITY case|nmod|_ -LSB-|dobj|case -LSB-|parataxis|_ _|dobj|mutation mutation|compound|END_ENTITY -LSB- A case of nt 1004C _ -- > _ A G6PD gene mutation in Yunnan Han people -RSB- . 12626421 2 100-4G11-A 458,468 phospholipase_A2 645,661 100-4G11-A phospholipase A2 MESH:C420352 18778(Tax:10090) Chemical Gene mAb|appos|START_ENTITY selected|nsubjpass|mAb selected|nmod|panel panel|nmod|mAbs mAbs|acl|generated generated|advcl|recognized recognized|ccomp|horseradish horseradish|xcomp|peroxidase peroxidase|conj|END_ENTITY An IgM mAb -LRB- 100-4G11-A -RRB- was selected from a panel of anti-glycan mAbs generated from Schistosoma-infected or immunized mice because it recognized both a plant glycoprotein horseradish peroxidase and phospholipase_A2 from honeybee venom . 26038891 3 10058F4 319,326 Myc 344,347 10058F4 Myc null 4609 Chemical Gene arsenic_trioxide|conj|START_ENTITY arsenic_trioxide|appos|inhibitor inhibitor|nmod|END_ENTITY We found that both arsenic_trioxide and 10058F4 , an inhibitor of Myc , induced differentiation of cancer stem-like cells -LRB- CSC -RRB- of GBM and that arsenic_trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects . 26038891 3 10058F4 492,499 Myc 344,347 10058F4 Myc null 4609 Chemical Gene effect|nmod|START_ENTITY enhanced|dobj|effect induced|conj|enhanced induced|nsubj|arsenic_trioxide arsenic_trioxide|appos|inhibitor inhibitor|nmod|END_ENTITY We found that both arsenic_trioxide and 10058F4 , an inhibitor of Myc , induced differentiation of cancer stem-like cells -LRB- CSC -RRB- of GBM and that arsenic_trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects . 25689483 10 10058-F4 1547,1555 ABCB5 1580,1585 10058-F4 ABCB5 null 77706(Tax:10090) Chemical Gene treatment|nummod|START_ENTITY decreased|nsubj|treatment decreased|dobj|level level|compound|END_ENTITY 10058-F4 treatment decreased the ABCB5 expression level in the presence or absence of 5-FU . 25689483 7 10058-F4 1045,1053 ABCB5 1096,1101 10058-F4 ABCB5 null 340273 Chemical Gene inhibited|dep|START_ENTITY inhibited|nmod|promoter promoter|compound|END_ENTITY c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level . 25689483 7 10058-F4 1045,1053 ABCB5 1137,1142 10058-F4 ABCB5 null 340273 Chemical Gene inhibited|dep|START_ENTITY inhibited|advcl|leading leading|nmod|decrease decrease|nmod|level level|compound|END_ENTITY c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level . 17159602 7 10058-F4 952,960 alpha-fetoprotein 994,1011 10058-F4 alpha-fetoprotein null 174 Chemical Gene decreased|nsubj|START_ENTITY decreased|dobj|levels levels|amod|END_ENTITY Besides , 10058-F4 also significantly decreased the alpha-fetoprotein levels , an indicator for hepatocellular_carcinoma differentiation . 25143136 5 10058-F4 758,766 Annexin_V 721,730 10058-F4 Annexin V null 308 Chemical Gene inhibited|nsubj|START_ENTITY found|ccomp|inhibited found|advcl|Using Using|dobj|cytometry cytometry|conj|assays assays|compound|END_ENTITY Using MTT assay , colony formation , flow cytometry and Annexin_V FITC assays , we found that 10058-F4 significantly inhibited cell proliferation of both SKOV3 and Hey ovarian_cancer cells in a dose dependent manner through induction of apoptosis and cell cycle G1 arrest . 17046567 6 10058-F4 943,951 Bax 1064,1067 10058-F4 Bax MESH:C524814 581 Chemical Gene apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|upregulation upregulation|nmod|END_ENTITY Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 . 17046567 6 10058-F4 943,951 Bcl-2 1041,1046 10058-F4 Bcl-2 MESH:C524814 596 Chemical Gene apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|nmod|END_ENTITY Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 . 21640157 6 10058-F4 1230,1238 Bcl-2 1219,1224 10058-F4 Bcl-2 null 596 Chemical Gene ABT-263|conj|START_ENTITY ABT-263|conj|inhibitor inhibitor|nmod|END_ENTITY Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition . 21640157 6 10058-F4 1230,1238 Bcl-2 1350,1355 10058-F4 Bcl-2 null 596 Chemical Gene ABT-263|conj|START_ENTITY Using|dobj|ABT-263 found|advcl|Using found|ccomp|sensitive sensitive|nmod|death death|nmod|result result|nmod|inhibition inhibition|compound|END_ENTITY Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition . 17046567 6 10058-F4 943,951 caspase_3 1122,1131 10058-F4 caspase 3 MESH:C524814 836 Chemical Gene apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|cleavage cleavage|nmod|END_ENTITY Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 . 25143136 7 10058-F4 1094,1102 caspase-3 1123,1132 10058-F4 caspase-3 null 836 Chemical Gene treated|nmod|START_ENTITY ovarian_cancer|acl|treated cultures|nmod|ovarian_cancer showed|nsubj|cultures showed|dobj|induction induction|nmod|activity activity|amod|END_ENTITY Consistently , primary cultures of ovarian_cancer treated with 10058-F4 showed induction of caspase-3 activity and inhibition of cell proliferation in 15 of 18 cases . 16410134 6 10058-F4 590,598 c-Myc 564,569 10058-F4 c-Myc MESH:C524814 24577(Tax:10116) Chemical Gene compound|nummod|START_ENTITY inhibitor|appos|compound inhibitor|amod|END_ENTITY Growth effects of a c-Myc inhibitor , compound 10058-F4 , were determined in these 4 lines using 3 - -LRB- 4,5-dimethylthiazol-2-yl -RRB- -2,5 - diphenyltetrazolium_bromide analyses and direct cell counts . 17046567 0 10058-F4 34,42 c-Myc 17,22 10058-F4 c-Myc MESH:C524814 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY A small-molecule c-Myc inhibitor , 10058-F4 , induces cell-cycle arrest , apoptosis , and myeloid differentiation of human acute_myeloid_leukemia . 17046567 5 10058-F4 812,820 c-Myc 870,875 10058-F4 c-Myc MESH:C524814 4609 Chemical Gene cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|dobj|expression expression|amod|END_ENTITY RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 . 17159602 0 10058-F4 32,40 c-Myc 15,20 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY Small-molecule c-Myc inhibitor , 10058-F4 , inhibits proliferation , downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular_carcinoma cells . 17159602 3 10058-F4 467,475 c-Myc 450,455 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY The potential of using small-molecule c-Myc inhibitor , 10058-F4 , was evaluated on hepatocellular_carcinoma cell lines , HepG2 and Hep3B cells . 17159602 4 10058-F4 589,597 c-Myc 702,707 10058-F4 c-Myc null 4609 Chemical Gene sensitive|nmod|START_ENTITY sensitive|advcl|demonstrated demonstrated|nmod|viability viability|conj|levels levels|amod|END_ENTITY HepG2 cells were more sensitive to 10058-F4 than Hep3B cells , as demonstrated by reduced cell viability , marked morphological changes and decreased c-Myc levels . 19114306 3 10058-F4 402,410 c-Myc 451,456 10058-F4 c-Myc null 4609 Chemical Gene effect|nmod|START_ENTITY effect|dep|small-molecule small-molecule|dep|disordered disordered|dobj|monomers monomers|amod|END_ENTITY We show that the effect of 10058-F4 -LRB- a small-molecule that binds disordered c-Myc monomers and disrupts the c-Myc-Max complex -RRB- on both c-Myc-Max heterodimerization and DNA binding is dependent on the nature of the Max isoform . 19180571 4 10058-F4 770,778 c-Myc 754,759 10058-F4 c-Myc null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY JAK inhibitor AG490 and c-Myc inhibitor 10058-F4 , both , reduced IL-5-mediated cell proliferation in a dose - and time-dependent manner . 20170530 10 10058-F4 1470,1478 c-Myc 1453,1458 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY The induction effect of HBx was inhibited after treatment with c-Myc inhibitor , 10058-F4 . 20423888 8 10058-F4 935,943 c-Myc 918,923 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY Furthermore , a small-molecule c-Myc inhibitor , 10058-F4 represses PC-1 gene expression in C4-2 cell line . 21618595 6 10058-F4 891,899 c-Myc 874,879 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY Furthermore , we found a comparable decrease in proliferation and G0/G1 accumulation of 786-0 and RC-2 cells after treatment with a small molecule c-Myc inhibitor , 10058-F4 . 21640157 6 10058-F4 1230,1238 c-Myc 1257,1262 10058-F4 c-Myc null 4609 Chemical Gene ABT-263|conj|START_ENTITY Using|dobj|ABT-263 Using|advcl|END_ENTITY Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition . 21640157 6 10058-F4 1230,1238 c-Myc 1375,1380 10058-F4 c-Myc null 4609 Chemical Gene ABT-263|conj|START_ENTITY Using|dobj|ABT-263 found|advcl|Using found|ccomp|sensitive sensitive|nmod|inhibition inhibition|amod|END_ENTITY Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition . 22302044 5 10058-F4 851,859 c-Myc 885,890 10058-F4 c-Myc null 4609 Chemical Gene cells|nmod|START_ENTITY pretreatment|nmod|cells pretreatment|appos|inhibitor inhibitor|nmod|END_ENTITY Nevertheless , pretreatment of cells with 10058-F4 , a specific inhibitor of c-Myc , almost eliminated the nicotinamide-induced radiosensitive effect . 24124686 6 10058-F4 778,786 c-Myc 762,767 10058-F4 c-Myc null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY After a pre-treatment of c-Myc inhibitor 10058-F4 , the apoptosis of AML cell was also evaluated . 25143136 4 10058-F4 562,570 c-Myc 545,550 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY Our objective was to evaluate the potential effects of small-molecule c-Myc inhibitor , 10058-F4 , on ovarian_carcinoma cells and the underlying mechanisms by which 10058-F4 exerts its actions . 25143136 4 10058-F4 638,646 c-Myc 545,550 10058-F4 c-Myc null 4609 Chemical Gene exerts|nsubj|START_ENTITY mechanisms|acl:relcl|exerts cells|conj|mechanisms evaluate|nmod|cells evaluate|dobj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY Our objective was to evaluate the potential effects of small-molecule c-Myc inhibitor , 10058-F4 , on ovarian_carcinoma cells and the underlying mechanisms by which 10058-F4 exerts its actions . 25143136 8 10058-F4 1214,1222 c-Myc 1252,1257 10058-F4 c-Myc null 4609 Chemical Gene response|nmod|START_ENTITY independent|nsubj|response independent|dep|level level|nmod|over-expression over-expression|amod|END_ENTITY The response to 10058-F4 was independent the level of c-Myc protein over-expression in primary cultures of ovarian_carcinoma . 26211592 0 10058-F4 23,31 c-Myc 14,19 10058-F4 c-Myc null 4609 Chemical Gene END_ENTITY|nmod|START_ENTITY Inhibition of c-Myc by 10058-F4 induces growth_arrest and chemosensitivity in pancreatic_ductal_adenocarcinoma . 26211592 3 10058-F4 402,410 c-Myc 385,390 10058-F4 c-Myc null 4609 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY The c-Myc inhibitor , 10058-F4 , has been reported act as a tumor suppressor in several different tumors . 26548696 9 10058-F4 2233,2241 c-Myc 2187,2192 10058-F4 c-Myc null 4609 Chemical Gene using|dobj|START_ENTITY tested|xcomp|using tested|nsubjpass|role role|nmod|END_ENTITY The role of c-Myc was tested in vitro using the inhibitor 10058-F4 , which , over time , decreased basal RNA and MPS in a dose-dependent manner -LRB- correlation of RNA and MPS , r -LRB- 2 -RRB- = 0.98 -RRB- , even though it had no effect on the acute stimulation of protein synthesis . 20515470 10 10058-F4 1683,1691 c-MYC 1667,1672 10058-F4 c-MYC null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY The c-MYC inhibitor 10058-F4 suppressed the tumorigenicity of Pim1-expressing prostate_cancer cells . 20515470 15 10058-F4 2317,2325 c-MYC 2301,2306 10058-F4 c-MYC null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY We also made the novel discovery that treatment of cells with the c-MYC inhibitor 10058-F4 leads to a reduction in Pim1 protein levels . 20515470 6 10058-F4 1090,1098 c-MYC 1005,1010 10058-F4 c-MYC null 4609 Chemical Gene inhibitor|appos|START_ENTITY using|dobj|inhibitor c-MYC|dep|using inhibited|xcomp|c-MYC inhibited|advcl|validate validate|ccomp|induces induces|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference . 20515470 6 10058-F4 1090,1098 c-MYC 1050,1055 10058-F4 c-MYC null 4609 Chemical Gene inhibitor|appos|START_ENTITY using|dobj|inhibitor END_ENTITY|dep|using To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference . 23525267 7 10058-F4 1187,1195 c-MYC 1156,1161 10058-F4 c-MYC null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt_lymphoma cells . 24859015 3 10058-F4 467,475 c-MYC 498,503 10058-F4 c-MYC null 4609 Chemical Gene START_ENTITY|dep|known known|nmod|domain domain|amod|END_ENTITY We have previously demonstrated that the small molecule 10058-F4 , known to bind to the c-MYC bHLHZip dimerization domain and inhibiting the c-MYC/MAX interaction , also interferes with the MYCN/MAX dimerization in vitro and imparts anti-tumorigenic effects in neuroblastoma_tumor models with MYCN overexpression . 25689483 7 10058-F4 1045,1053 c-MYC 1028,1033 10058-F4 c-MYC null 4609 Chemical Gene inhibited|dep|START_ENTITY inhibited|nsubj|inhibitor inhibitor|amod|END_ENTITY c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level . 25689483 7 10058-F4 1045,1053 c-MYC 1075,1080 10058-F4 c-MYC null 4609 Chemical Gene inhibited|dep|START_ENTITY inhibited|dobj|binding binding|amod|END_ENTITY c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level . 27789709 4 10058-F4 645,653 c-MYC 629,634 10058-F4 c-MYC null 4609 Chemical Gene START_ENTITY|amod|END_ENTITY Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- . 27789709 4 10058-F4 645,653 c-MYC 678,683 10058-F4 c-MYC null 4609 Chemical Gene blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|END_ENTITY Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- . 17046567 6 10058-F4 943,951 cytochrome_C 1092,1104 10058-F4 cytochrome C MESH:C524814 54205 Chemical Gene apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|release release|nmod|END_ENTITY Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 . 24977668 6 10058-F4 896,904 FOXO1 808,813 10058-F4 FOXO1 null 2308 Chemical Gene increased|nsubj|START_ENTITY resulted|conj|increased resulted|nmod|upregulation upregulation|nmod|mRNA mRNA|compound|END_ENTITY Targeting JAK2 activity by the small molecular weight inhibitor TG101348 resulted in upregulation of FOXO1 mRNA and protein expression in MedB-1 and U2940 cell lines , and the MYC inhibitor 10058-F4 increased FOXO1 mRNA in MedB-1 cells . 23525267 7 10058-F4 1187,1195 GLI1 1210,1214 10058-F4 GLI1 null 2735 Chemical Gene downregulates|nsubj|START_ENTITY downregulates|dobj|mRNA mRNA|amod|END_ENTITY The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt_lymphoma cells . 20170530 10 10058-F4 1470,1478 HBx 1414,1417 10058-F4 HBx null 944566(Tax:10407) Chemical Gene inhibitor|amod|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubjpass|effect effect|nmod|END_ENTITY The induction effect of HBx was inhibited after treatment with c-Myc inhibitor , 10058-F4 . 24977668 6 10058-F4 896,904 JAK2 717,721 10058-F4 JAK2 null 3717 Chemical Gene increased|nsubj|START_ENTITY resulted|conj|increased resulted|csubj|Targeting Targeting|dobj|activity activity|compound|END_ENTITY Targeting JAK2 activity by the small molecular weight inhibitor TG101348 resulted in upregulation of FOXO1 mRNA and protein expression in MedB-1 and U2940 cell lines , and the MYC inhibitor 10058-F4 increased FOXO1 mRNA in MedB-1 cells . 17942906 2 10058-F4 147,155 MYC 212,215 10058-F4 MYC null 4609 Chemical Gene Using|dobj|START_ENTITY down-regulated|advcl|Using down-regulated|nsubjpass|compound compound|acl:relcl|inhibits inhibits|dobj|factor factor|conj|protein protein|compound|END_ENTITY Using 10058-F4 , a compound that inhibits MYC-MAX transcription factor , MYC protein and gene expression were down-regulated in Namalwa cells , a Burkitt_lymphoma . 24859015 3 10058-F4 467,475 MYCN 702,706 10058-F4 MYCN null 4613 Chemical Gene interferes|nsubj|START_ENTITY interferes|nmod|overexpression overexpression|compound|END_ENTITY We have previously demonstrated that the small molecule 10058-F4 , known to bind to the c-MYC bHLHZip dimerization domain and inhibiting the c-MYC/MAX interaction , also interferes with the MYCN/MAX dimerization in vitro and imparts anti-tumorigenic effects in neuroblastoma_tumor models with MYCN overexpression . 24859015 7 10058-F4 1536,1544 MYCN 1473,1477 10058-F4 MYCN null 4613 Chemical Gene metabolite|amod|START_ENTITY found|nmod|metabolite found|dobj|interaction interaction|nmod|END_ENTITY Using a proximity ligation assay , we found reduced interaction between MYCN and MAX after treatment with all molecules except for the 10058-F4 metabolite C-m/z 232 and the non-binder 10058-F4 -LRB- 7RH -RRB- . 24859015 7 10058-F4 1585,1593 MYCN 1473,1477 10058-F4 MYCN null 4613 Chemical Gene metabolite|conj|START_ENTITY found|nmod|metabolite found|dobj|interaction interaction|nmod|END_ENTITY Using a proximity ligation assay , we found reduced interaction between MYCN and MAX after treatment with all molecules except for the 10058-F4 metabolite C-m/z 232 and the non-binder 10058-F4 -LRB- 7RH -RRB- . 17046567 5 10058-F4 812,820 p21 919,922 10058-F4 p21 MESH:C524814 644914 Chemical Gene cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|conj|upregulated upregulated|xcomp|inhibitors inhibitors|conj|END_ENTITY RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 . 17046567 5 10058-F4 812,820 p27 927,930 10058-F4 p27 MESH:C524814 10671 Chemical Gene cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|conj|upregulated upregulated|xcomp|inhibitors inhibitors|conj|END_ENTITY RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 . 20515470 11 10058-F4 1779,1787 Pim1 1825,1829 10058-F4 Pim1 null 5292 Chemical Gene treatment|nummod|START_ENTITY led|nsubj|treatment led|nmod|reduction reduction|nmod|protein protein|amod|END_ENTITY Interestingly , 10058-F4 treatment also led to a reduction of Pim1 protein but not mRNA . 20515470 15 10058-F4 2317,2325 Pim1 2350,2354 10058-F4 Pim1 null 5292 Chemical Gene cells|nmod|START_ENTITY treatment|nmod|cells leads|nsubj|treatment leads|nmod|reduction reduction|nmod|levels levels|amod|END_ENTITY We also made the novel discovery that treatment of cells with the c-MYC inhibitor 10058-F4 leads to a reduction in Pim1 protein levels . 20515470 6 10058-F4 1090,1098 Pim1 936,940 10058-F4 Pim1 null 5292 Chemical Gene inhibitor|appos|START_ENTITY using|dobj|inhibitor c-MYC|dep|using inhibited|xcomp|c-MYC inhibited|advcl|validate validate|ccomp|induces induces|nsubj|END_ENTITY To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference . 27789709 4 10058-F4 645,653 PRC 685,688 10058-F4 PRC null 23082 Chemical Gene blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|c-MYC c-MYC|conj|END_ENTITY Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- . 27031051 9 10058-F4 1169,1177 TRPM8 1223,1228 10058-F4 TRPM8 null 171382(Tax:10090) Chemical Gene administration|nmod|START_ENTITY prevented|nsubj|administration prevented|dobj|cold_allodynia cold_allodynia|conj|increase increase|nmod|mRNA mRNA|compound|END_ENTITY Prophylactic administration of the c-Myc inhibitor 10058-F4 prevented cold_allodynia and the increase of TRPM8 mRNA after oxaliplatin injection . 9173919 4 1006-amino-acid 580,595 atrophin-1 817,827 1006-amino-acid atrophin-1 null 29515(Tax:10116) Chemical Gene product|amod|START_ENTITY contain|nsubj|product contain|conj|contain contain|dobj|regions regions|acl|alternating alternating|xcomp|similar similar|nmod|those those|acl|found found|advcl|END_ENTITY The 1006-amino-acid product of this gene , which we have termed rat atrophin related protein -LRB- rARP -RRB- , does not contain a glutamine repeat , but it does contain two regions of alternating acidic and basic amino residues similar to those found in atrophin-1 . 18984437 5 1006_Framingham_offspring 863,888 MMP-9 768,773 1006 Framingham offspring MMP-9 MESH:C076134 4318 Chemical Gene carotid|nmod|START_ENTITY PIIINP|advcl|carotid related|conj|PIIINP related|xcomp|circulating circulating|dobj|END_ENTITY METHODS : We related circulating MMP-9 , TIMP-1 , and/or PIIINP concentrations to carotid atherosclerosis on duplex ultrasound in 1006_Framingham_offspring -LRB- mean age 58 years , 56 % women -RRB- who attended a routine examination from 1995 to 1998 . 18984437 5 1006_Framingham_offspring 863,888 TIMP-1 775,781 1006 Framingham offspring TIMP-1 MESH:C076134 7076 Chemical Gene carotid|nmod|START_ENTITY PIIINP|advcl|carotid related|conj|PIIINP related|xcomp|circulating circulating|dobj|MMP-9 MMP-9|appos|END_ENTITY METHODS : We related circulating MMP-9 , TIMP-1 , and/or PIIINP concentrations to carotid atherosclerosis on duplex ultrasound in 1006_Framingham_offspring -LRB- mean age 58 years , 56 % women -RRB- who attended a routine examination from 1995 to 1998 . 24098099 4 10074-A4 762,770 c-Myc 664,669 10074-A4 c-Myc null 4609 Chemical Gene ligand|dep|START_ENTITY peptide|amod|ligand peptide|amod|END_ENTITY To better understand the structure of IDPs and their interactions with small molecule ligands , we performed extensive simulations on the c-Myc peptide and its binding to a reported small molecule inhibitor , ligand 10074-A4 . 19022175 2 10074-G5 443,451 c-Myc 458,463 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene 10058-F4|conj|START_ENTITY molecules|appos|10058-F4 bind|nsubj|molecules bind|xcomp|END_ENTITY We have identified the binding sites and determined the structural means by which two unrelated small molecules , 10058-F4 and 10074-G5 , bind c-Myc and stabilize the ID monomer over the highly ordered c-Myc-Max heterodimer . 19432426 4 10074-G5 570,578 c-Myc 626,631 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene 10058-F4|conj|START_ENTITY inhibitors|appos|10058-F4 bound|nsubj|inhibitors bound|nmod|regions regions|nmod|domain domain|amod|END_ENTITY Previously we showed that two c-Myc-Max inhibitors , 10058-F4 and 10074-G5 , bound to distinct ID regions of the monomeric c-Myc bHLHZip domain . 20801893 11 10074-G5 1792,1800 c-Myc 1898,1903 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene metabolites|nummod|START_ENTITY identification|nmod|metabolites help|nsubj|identification help|xcomp|design design|dobj|inhibitors inhibitors|nmod|END_ENTITY Our identification of 10074-G5 metabolites in mice will help design new , more metabolically stable small-molecule inhibitors of c-Myc . 20801893 3 10074-G5 510,518 c-Myc 565,570 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene activity|appos|START_ENTITY activity|amod|binds binds|xcomp|and and|ccomp|distorts distorts|dobj|domain domain|nmod|END_ENTITY The small molecule 7-nitro-N - -LRB- 2-phenylphenyl -RRB- -2,1,3 - benzoxadiazol-4-amine -LRB- 10074-G5 -RRB- binds to and distorts the bHLH-ZIP domain of c-Myc , thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity . 21933022 8 10074-G5 1266,1274 c-Myc 1328,1333 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene treated|nmod|START_ENTITY cells|acl|treated experiment|conj|cells displayed|nmod|experiment displayed|nmod|suggestive suggestive|compound|pERK pERK|conj|END_ENTITY In another experiment , U251 and 5310 cells treated with 10074-G5 , c-Myc/Max inhibitor displayed reduction in pERK and c-Myc levels suggestive of a positive feedback loop between ERK/c-Myc/Max molecules . 23177256 0 10074-G5 48,56 c-Myc 32,37 10074-G5 c-Myc MESH:C534883 4609 Chemical Gene START_ENTITY|amod|END_ENTITY Pharmacophore identification of c-Myc inhibitor 10074-G5 . 26472107 12 10074-G5 1565,1573 c-MYC 1516,1521 10074-G5 c-MYC MESH:C534883 4609 Chemical Gene 10058-F4|conj|START_ENTITY END_ENTITY|dep|10058-F4 Molecular docking studies revealed that shikonin and its derivatives bind to the same DNA-binding domain of c-MYC as the known c-MYC inhibitors 10058-F4 and 10074-G5 . 26472107 12 10074-G5 1565,1573 c-MYC 1535,1540 10074-G5 c-MYC MESH:C534883 4609 Chemical Gene 10058-F4|conj|START_ENTITY c-MYC|dep|10058-F4 c-MYC|nmod|inhibitors inhibitors|amod|END_ENTITY Molecular docking studies revealed that shikonin and its derivatives bind to the same DNA-binding domain of c-MYC as the known c-MYC inhibitors 10058-F4 and 10074-G5 . 21933022 8 10074-G5 1266,1274 pERK 1319,1323 10074-G5 pERK MESH:C534883 9451 Chemical Gene treated|nmod|START_ENTITY cells|acl|treated experiment|conj|cells displayed|nmod|experiment displayed|nmod|suggestive suggestive|compound|END_ENTITY In another experiment , U251 and 5310 cells treated with 10074-G5 , c-Myc/Max inhibitor displayed reduction in pERK and c-Myc levels suggestive of a positive feedback loop between ERK/c-Myc/Max molecules . 11485546 1 1008-1010 286,295 epidermal_growth_factor_receptor 208,240 1008-1010 epidermal growth factor receptor MESH:C572335 1956 Chemical Gene Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- expression|nmod|Kurten Kurten|compound|END_ENTITY Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- . 11485546 1 1008-1010 286,295 SNX1 91,95 1008-1010 SNX1 MESH:C572335 6642 Chemical Gene Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- regulate|dobj|expression regulate|nsubj|Sorting_nexin_1 Sorting_nexin_1|appos|END_ENTITY Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- . 11485546 1 1008-1010 286,295 Sorting_nexin_1 74,89 1008-1010 Sorting nexin 1 MESH:C572335 6642 Chemical Gene Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- regulate|dobj|expression regulate|nsubj|END_ENTITY Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- . 18398080 8 101-106 1509,1516 LDL-C 1456,1461 101-106 LDL-C MESH:C588327 22796 Chemical Gene 104|appos|START_ENTITY 72|conj|104 72|nsubj|levels levels|nmod|END_ENTITY Mean -LRB- 95 % confidence interval -RRB- levels for LDL-C in the last 12 months were 72 -LRB- 69-75 -RRB- and 104 -LRB- 101-106 -RRB- mg/dL and SBP levels were 117 -LRB- 115-118 -RRB- and 129 -LRB- 128-130 -RRB- mm Hg in the aggressive vs standard groups , respectively . 14610073 6 10-11-amino_acid 1095,1111 perilipin_A 1284,1295 10-11-amino acid perilipin A MESH:D000596 103968(Tax:10090) Chemical Gene sequences|amod|START_ENTITY amino_acids|nmod|sequences sequence|nmod|amino_acids predicted|nsubj|sequence predicted|conj|critical critical|nsubj|terminus terminus|nmod|amino_acids amino_acids|acl:relcl|unique unique|nmod|END_ENTITY The amino-terminal sequence between amino_acids 122 and 222 , including four 10-11-amino_acid sequences predicted to form amphipathic beta-strands and a consensus site for cAMP-dependent protein kinase , and the carboxyl terminus of 112 amino_acids that is unique to perilipin_A were critical to facilitate triacylglycerol storage . 8272570 4 10,11-dehydro-2-acetoxytrimipramine 528,563 C10 516,519 10,11-dehydro-2-acetoxytrimipramine C10 MESH:C085056 3226 Chemical Gene give|xcomp|START_ENTITY resulted|xcomp|give resulted|nmod|END_ENTITY Acetylation of the new metabolite resulted in dehydration at C10 to give 10,11-dehydro-2-acetoxytrimipramine . 19107468 6 10,11-didehydro 1493,1508 SCX 1435,1438 10,11-didehydro SCX null 642658 Chemical Gene C9-epi|conj|START_ENTITY derivatives|amod|C9-epi separation|nmod|derivatives allowed|dobj|separation allowed|nsubj|materials materials|compound|END_ENTITY Furthermore , both SCX materials allowed successful separation of C9-epi and 10,11-didehydro derivatives from their respective educts in an application in synthetic Cinchona alkaloid chemistry . 20113739 2 10,11-dihydro-10-hydroxycarbamazepine 442,479 C18 617,620 10,11-dihydro-10-hydroxycarbamazepine C18 MESH:C039775 27241 Chemical Gene Oxcarbazepine|dep|START_ENTITY baseline|nsubj|Oxcarbazepine baseline|acl|separated separated|nmod|min min|nmod|column column|compound|END_ENTITY Oxcarbazepine and its metabolites -LRB- 10,11-dihydro-10-hydroxycarbamazepine , trans-10 ,11 - dihydro-10 ,11 - dihydroxycarbamazepine and 3-hydroxycarbamazepine -RRB- were baseline separated within 6.5 min on a reversed-phase C18 column with a phosphate buffer-acetonitrile-triethylamine mixture as the mobile phase . 2002449 2 10,11-dihydroxyaporphine 522,546 COMT 462,466 10,11-dihydroxyaporphine COMT CHEBI:48538 1312 Chemical Gene apomorphine|dep|START_ENTITY converted|nsubjpass|apomorphine conditions|acl:relcl|converted using|dobj|conditions END_ENTITY|acl|using In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine -LRB- 10,11-dihydroxyaporphine -RRB- is converted in high yield into its 10-methyl_ether , apocodeine . 8010982 1 10,11-epoxide 67,80 CYP2C8 57,63 10,11-epoxide CYP2C8 null 1558 Chemical Gene formation|amod|START_ENTITY Role|nmod|formation Role|nmod|CYP3A4 CYP3A4|conj|END_ENTITY Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation . 22137858 0 10,11-epoxide 97,110 CYP3A1/2 170,178 10,11-epoxide CYP3A1/2 null 25642;266682 Chemical Gene metabolite|amod|START_ENTITY pharmacokinetics|conj|metabolite hyperlipidemia|nmod|pharmacokinetics Effects|nmod|hyperlipidemia Effects|dep|Impact Impact|nmod|expression expression|nmod|END_ENTITY Effects of poloxamer_407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats : Impact of decreased expression of both CYP3A1/2 and microsomal_epoxide_hydrolase . 25545162 3 10,11-epoxide 719,732 CYP3A4 548,554 10,11-epoxide CYP3A4 null 1576 Chemical Gene product|amod|START_ENTITY CBZ|nmod|product turnover|nmod|CBZ leading|nmod|turnover engineered|xcomp|leading engineered|xcomp|mutants mutants|nsubj|END_ENTITY On the basis of these simulations , we engineered CYP3A4 mutants I369F , I369L , A370V , and A370L , in which the productive binding orientation was expected to be stabilized , thus leading to increased turnover of CBZ to the 10,11-epoxide product . 8010982 1 10,11-epoxide 67,80 CYP3A4 46,52 10,11-epoxide CYP3A4 null 1576 Chemical Gene formation|amod|START_ENTITY Role|nmod|formation Role|nmod|END_ENTITY Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation . 8010982 5 10,11-epoxide 1234,1247 CYP3A4 1198,1204 10,11-epoxide CYP3A4 null 1576 Chemical Gene formation|amod|START_ENTITY catalyst|nmod|formation catalyst|nsubj|END_ENTITY These findings indicate that CYP3A4 is the principal catalyst of 10,11-epoxide formation in human liver . 22137858 0 10,11-epoxide 97,110 microsomal_epoxide_hydrolase 183,211 10,11-epoxide microsomal epoxide hydrolase null 25315(Tax:10116) Chemical Gene metabolite|amod|START_ENTITY pharmacokinetics|conj|metabolite hyperlipidemia|nmod|pharmacokinetics Effects|nmod|hyperlipidemia Effects|dep|Impact Impact|nmod|expression expression|nmod|CYP3A1/2 CYP3A1/2|conj|END_ENTITY Effects of poloxamer_407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats : Impact of decreased expression of both CYP3A1/2 and microsomal_epoxide_hydrolase . 7664272 3 10,11-methylenedioxy-camptothecin 722,755 CPT-11 597,603 10,11-methylenedioxy-camptothecin CPT-11 MESH:C120496 963084(Tax:115711) Chemical Gene camptothecin|conj|START_ENTITY cross-resistant|nmod|camptothecin report|conj|cross-resistant report|ccomp|cross-resistant cross-resistant|nmod|topotecan topotecan|conj|END_ENTITY We now report that this cell line is highly cross-resistant to the camptothecin analogues topotecan -LRB- 180-fold -RRB- , 9-aminocamptothecin -LRB- 120-fold -RRB- , CPT-11 -LRB- 56-fold -RRB- , and SN38 -LRB- 101-fold -RRB- , but is only mildly cross-resistant to the parent compound camptothecin -LRB- 3.2-fold -RRB- and 10,11-methylenedioxy-camptothecin -LRB- 2.9-fold -RRB- . 11052623 2 10,11-methylenedioxy-CPT 1466,1490 CPT-11 1398,1404 10,11-methylenedioxy-CPT CPT-11 null 963084(Tax:115711) Chemical Gene that|conj|START_ENTITY that|nsubj|activity activity|nmod|SN-38 SN-38|dep|metabolite metabolite|nmod|END_ENTITY Antiproliferative activity of SN-38 -LRB- the active metabolite of CPT-11 -RRB- , and TPT was compared to that of CPT and two CPT analogues , 10,11-methylenedioxy-CPT -LRB- MDC -RRB- , and the alkylating derivative , 7-chloromethyl-10 ,11 - MDC -LRB- CMMDC -RRB- . 16787918 6 1012-1212 1067,1076 Pax3 1093,1097 1012-1212 Pax3 MESH:C105975 18505(Tax:10090) Chemical Gene bind|nummod|START_ENTITY bp|conj|bind elements|nmod|bp acetylated|nsubj|elements acetylated|dobj|END_ENTITY Additionally , by using a combination of co-immunoprecipitation and chromatin immunoprecipitation , we show that the TGFbeta2 cis-regulatory elements between bp 741-940 and bp 1012-1212 bind acetylated Pax3 and are associated with p300/CBP and histone deacetylases . 16787918 6 1012-1212 1067,1076 TGFbeta2 1008,1016 1012-1212 TGFbeta2 MESH:C105975 21808(Tax:10090) Chemical Gene bind|nummod|START_ENTITY bp|conj|bind elements|nmod|bp elements|amod|END_ENTITY Additionally , by using a combination of co-immunoprecipitation and chromatin immunoprecipitation , we show that the TGFbeta2 cis-regulatory elements between bp 741-940 and bp 1012-1212 bind acetylated Pax3 and are associated with p300/CBP and histone deacetylases . 28792212 2 10-12-amino_acid 314,330 LC8 278,281 10-12-amino acid LC8 null 8655 Chemical Gene sequence|amod|START_ENTITY is|nmod|sequence is|ccomp|is END_ENTITY|acl:relcl|is A common feature among the more than 100 essential LC8 binding proteins is that in the 10-12-amino_acid recognition sequence there is a conserved QT motif but variable amino_acids N - and C-terminal to the QT_pair . 11435430 2 10-12-amino_acid 321,337 PC1 269,272 10-12-amino acid PC1 null 5122 Chemical Gene segment|amod|START_ENTITY confined|nmod|segment confined|nsubjpass|sequence sequence|compound|END_ENTITY The PC1 inhibitory sequence is mostly confined within a 10-12-amino_acid segment near the C terminus of the conserved human proSAAS and contains the critical KR -LRB- 244 -RRB- dibasic motif . 11435430 2 10-12-amino_acid 321,337 proSAAS 389,396 10-12-amino acid proSAAS null 27344 Chemical Gene segment|amod|START_ENTITY segment|nmod|terminus terminus|nmod|END_ENTITY The PC1 inhibitory sequence is mostly confined within a 10-12-amino_acid segment near the C terminus of the conserved human proSAAS and contains the critical KR -LRB- 244 -RRB- dibasic motif . 10358058 1 1012-amino_acid_polypeptide_cPLA2-beta 98,136 cPLA2-alpha 173,184 1012-amino acid polypeptide cPLA2-beta cPLA2-alpha MESH:C105975 5321 Chemical Gene START_ENTITY|acl:relcl|has has|nmod|domain domain|amod|END_ENTITY We have isolated a cDNA encoding a 1012-amino_acid_polypeptide_cPLA2-beta , that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain . 7981215 1 10-12_amino_acids 110,127 rhodopsin 227,236 10-12 amino acids rhodopsin null 6010 Chemical Gene Peptides|nmod|START_ENTITY Peptides|acl:relcl|overlapped overlapped|nmod|tail tail|nmod|END_ENTITY Peptides of 10-12_amino_acids in length , which overlapped with the sequence of the last 20 amino_acids in the C-terminal tail of rhodopsin , were synthesized and used as substrates for rhodopsin_kinase . 7981215 1 10-12_amino_acids 110,127 rhodopsin_kinase 282,298 10-12 amino acids rhodopsin kinase null 131890 Chemical Gene Peptides|nmod|START_ENTITY synthesized|nsubjpass|Peptides synthesized|nmod|substrates substrates|nmod|END_ENTITY Peptides of 10-12_amino_acids in length , which overlapped with the sequence of the last 20 amino_acids in the C-terminal tail of rhodopsin , were synthesized and used as substrates for rhodopsin_kinase . 3335854 10 1012S-Sepharose 1538,1553 P36 1531,1534 1012S-Sepharose P36 MESH:C060004 406192(Tax:9823) Chemical Gene concentrations|amod|START_ENTITY inhibit|nmod|concentrations inhibit|dobj|binding binding|nmod|END_ENTITY However , the ability of the gamma-aminobutyrate/benzodiazepine receptor inverse agonists , methyl - and ethyl-beta-carboline-3-carboxylate , to inhibit the binding of P36 to 1012S-Sepharose at relatively low concentrations indicates that P36 exhibits a degree of binding specificity . 3335854 10 1012S-Sepharose 1538,1553 P36 1602,1605 1012S-Sepharose P36 MESH:C060004 406192(Tax:9823) Chemical Gene concentrations|amod|START_ENTITY inhibit|nmod|concentrations receptor|acl|inhibit ability|nmod|receptor indicates|nsubj|ability indicates|ccomp|exhibits exhibits|nsubj|END_ENTITY However , the ability of the gamma-aminobutyrate/benzodiazepine receptor inverse agonists , methyl - and ethyl-beta-carboline-3-carboxylate , to inhibit the binding of P36 to 1012S-Sepharose at relatively low concentrations indicates that P36 exhibits a degree of binding specificity . 3335854 1 1012S-Sepharose 168,183 P36 250,253 1012S-Sepharose P36 MESH:C060004 406192(Tax:9823) Chemical Gene column|nmod|START_ENTITY chromatography|nmod|column resulted|nsubj|chromatography resulted|nmod|detection detection|nmod|protein protein|appos|END_ENTITY Benzodiazepine-affinity chromatography , on a column of 1012S-Sepharose , resulted in the detection and purification of a binding protein -LRB- P36 -RRB- from the cytosolic fraction of pig cerebral cortex . 17709415 2 1,014-amino-acid 271,287 Cdc42 371,376 1,014-amino-acid Cdc42 null 998 Chemical Gene toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|RhoA RhoA|conj|END_ENTITY These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain . 17709415 2 1,014-amino-acid 271,287 Rac1 361,365 1,014-amino-acid Rac1 null 5879 Chemical Gene toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|RhoA RhoA|conj|END_ENTITY These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain . 17709415 2 1,014-amino-acid 271,287 RhoA 355,359 1,014-amino-acid RhoA null 387 Chemical Gene toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|END_ENTITY These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain . 22070231 12 1014C 1556,1561 L1014 1436,1441 1014C L1014 null 1114359(Tax:272623) Chemical Gene substitution|nummod|START_ENTITY resulting|nmod|substitution mutation|acl|resulting identified|nmod|mutation identified|nsubjpass|mutations mutations|nmod|codon codon|compound|END_ENTITY Two alternative mutations within the L1014 codon were identified in Culex_pipiens molestus Forskal , 1775 , including a non-synonymous mutation resulting in a 1014C substitution . 9724739 6 101-5-8 979,986 p53 1003,1006 101-5-8 p53 MESH:C000591311 7157 Chemical Gene mutations|appos|START_ENTITY mutations|conj|deletion deletion|dep|END_ENTITY Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression . 9724739 6 101-5-8 979,986 p53 1026,1029 101-5-8 p53 MESH:C000591311 7157 Chemical Gene mutations|appos|START_ENTITY mutations|conj|deletion deletion|dep|forms forms|nmod|END_ENTITY Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression . 9724739 6 101-5-8 979,986 p53 1067,1070 101-5-8 p53 MESH:C000591311 7157 Chemical Gene mutations|appos|START_ENTITY exhibit|nsubj|mutations exhibit|dobj|increase increase|nmod|levels levels|compound|END_ENTITY Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression . 9724739 6 101-5-8 979,986 p53 975,978 101-5-8 p53 MESH:C000591311 7157 Chemical Gene mutations|appos|START_ENTITY mutations|dep|END_ENTITY Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression . 11960002 6 1015C 846,851 gata1 834,839 1015C gata1 null 30481(Tax:7955) Chemical Gene _|nummod|START_ENTITY gene|appos|_ gene|amod|END_ENTITY Through positional and candidate gene cloning approaches we identified a nonsense mutation in the gata1 gene , 1015C _ -- > _ T -LRB- Arg-339 _ -- > _ Stop -RRB- , in vlt -LRB- m651 -RRB- . 21699628 8 10-15_U 1114,1121 FXI 1009,1012 10-15 U FXI null 2160 Chemical Gene administration|nmod|START_ENTITY peri|dep|administration application|dep|peri application|dep|inhibitor inhibitor|conj|END_ENTITY The application required an investigator-initiated IRB-approved protocol for treatment and safety/efficacy monitoring that included : preoperative thrombophilia , FXI inhibitor and pharmacokinetic -LRB- PK -RRB- evaluations ; peri - postoperative administration of < = 4 doses of 10-15_U / kg Hemoleven ; DIC monitoring ; postoperative thromboprophylaxis ; observation for product efficacy and potential complications . 12172218 3 10-16-10-8_mol 594,608 angiotensin_II 502,516 10-16-10-8 mol angiotensin II MESH:C020748 183 Chemical Gene NA|dep|START_ENTITY noradrenaline|appos|NA endothelin-1|conj|noradrenaline endothelin-1|conj|END_ENTITY We assessed the effects of endothelin-1 -LRB- ET-1 -RRB- , angiotensin_II -LRB- AT -RRB- , endothelin-antagonists -LRB- BQ-123 and BQ-788 -RRB- and noradrenaline -LRB- NA , each 10-16-10-8_mol -RRB- on vasoconstriction in the human skin microcirculation in vivo in 25 healthy male volunteers -LRB- 13 with CC genotype , 12 TC/TT genotype -RRB- using laser Doppler flowmetry . 12172218 3 10-16-10-8_mol 594,608 endothelin-1 481,493 10-16-10-8 mol endothelin-1 MESH:C020748 1906 Chemical Gene NA|dep|START_ENTITY noradrenaline|appos|NA END_ENTITY|conj|noradrenaline We assessed the effects of endothelin-1 -LRB- ET-1 -RRB- , angiotensin_II -LRB- AT -RRB- , endothelin-antagonists -LRB- BQ-123 and BQ-788 -RRB- and noradrenaline -LRB- NA , each 10-16-10-8_mol -RRB- on vasoconstriction in the human skin microcirculation in vivo in 25 healthy male volunteers -LRB- 13 with CC genotype , 12 TC/TT genotype -RRB- using laser Doppler flowmetry . 8554512 2 10-16_carbon 437,449 albumin 325,332 10-16 carbon albumin null 213 Chemical Gene atoms|amod|START_ENTITY containing|dobj|atoms engineered|xcomp|containing engineered|nsubjpass|Insulins Insulins|nmod|affinity affinity|nmod|END_ENTITY Insulins with affinity for albumin were engineered by acylation of the epsilon-amino group of LysB29 with saturated fatty_acids containing 10-16_carbon atoms . 19959665 9 10,16-dihydroxypalmitate 1461,1485 CYP77A6 1291,1298 10,16-dihydroxypalmitate CYP77A6 null 820222(Tax:3702) Chemical Gene synthesis|nmod|START_ENTITY CYP86A4|nmod|synthesis acting|nmod|CYP86A4 hydroxylase|acl|acting provided|ccomp|hydroxylase provided|nsubj|Comparison Comparison|nmod|profiles profiles|nmod|knockouts knockouts|nmod|END_ENTITY Comparison of cutin monomer profiles in knockouts for CYP77A6 and the fatty_acid omega-hydroxylase CYP86A4 provided genetic evidence that CYP77A6 is an in-chain hydroxylase acting subsequently to CYP86A4 in the synthesis of 10,16-dihydroxypalmitate . 19959665 9 10,16-dihydroxypalmitate 1461,1485 CYP77A6 1375,1382 10,16-dihydroxypalmitate CYP77A6 null 820222(Tax:3702) Chemical Gene synthesis|nmod|START_ENTITY CYP86A4|nmod|synthesis acting|nmod|CYP86A4 hydroxylase|acl|acting hydroxylase|nsubj|END_ENTITY Comparison of cutin monomer profiles in knockouts for CYP77A6 and the fatty_acid omega-hydroxylase CYP86A4 provided genetic evidence that CYP77A6 is an in-chain hydroxylase acting subsequently to CYP86A4 in the synthesis of 10,16-dihydroxypalmitate . 21628525 3 10,16-dihydroxypalmitate 592,616 pec1 514,518 10,16-dihydroxypalmitate pec1 null 817232(Tax:3702) Chemical Gene fatty_acids|conj|START_ENTITY monomers|nmod|fatty_acids reduced|nsubjpass|monomers reduced|nmod|flowers flowers|amod|END_ENTITY In pec1 flowers , typical cutin monomers , such as - hydroxylated fatty_acids and 10,16-dihydroxypalmitate , are reduced to 40 % of wild-type levels and are accompanied by the appearance of lipidic inclusions within the epidermal cell . 10878014 5 1017-1237 692,701 Hklp2 636,641 1017-1237 Hklp2 MESH:C488695 56992 Chemical Gene residues|nummod|START_ENTITY comprised|dobj|residues mapped|dep|comprised mapped|nsubjpass|domain domain|nmod|END_ENTITY The interaction domain of Hklp2 was mapped to the portion that comprised residues 1017-1237 and that was phosphorylated in vitro by incubating with mitotic but not interphasic HeLa cell extracts . 15770500 2 10171A 368,374 perilipin 330,339 10171A perilipin MESH:D015283 5346 Chemical Gene T|nummod|START_ENTITY T|conj|T locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 15770500 2 10171A 368,374 PLIN 341,345 10171A PLIN MESH:D015283 5346 Chemical Gene T|nummod|START_ENTITY T|conj|T locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|perilipin perilipin|appos|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 15770500 2 10171A 368,374 PLIN 354,358 10171A PLIN MESH:D015283 5346 Chemical Gene T|nummod|START_ENTITY T|conj|T T|compound|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 19542440 4 1017-DRAK2 1074,1084 DRAK2 1037,1042 1017-DRAK2 DRAK2 MESH:C488695 98267(Tax:10090) Chemical Gene mice|nummod|START_ENTITY ectopically|appos|mice ectopically|acl|expressing expressing|dobj|END_ENTITY To further evaluate the differential role of DRAK2 in central vs peripheral tolerance and to assess its impact on the development of autoimmune_diseases , we have generated a transgenic -LRB- Tg -RRB- mouse_strain ectopically expressing DRAK2 via the lck proximal promoter -LRB- 1017-DRAK2 Tg mice -RRB- . 19542440 4 1017-DRAK2 1074,1084 DRAK2 856,861 1017-DRAK2 DRAK2 MESH:C488695 98267(Tax:10090) Chemical Gene mice|nummod|START_ENTITY ectopically|appos|mice generated|dobj|ectopically generated|ccomp|evaluate evaluate|dobj|role role|nmod|END_ENTITY To further evaluate the differential role of DRAK2 in central vs peripheral tolerance and to assess its impact on the development of autoimmune_diseases , we have generated a transgenic -LRB- Tg -RRB- mouse_strain ectopically expressing DRAK2 via the lck proximal promoter -LRB- 1017-DRAK2 Tg mice -RRB- . 27033423 6 10,17S-DHDHA 1047,1059 PD1 1002,1005 10,17S-DHDHA PD1 null 6139 Chemical Gene acid|appos|START_ENTITY D1|appos|acid D1|appos|END_ENTITY Other SPM included protectin D1 -LRB- PD1 -RRB- , 10S,17S-dihydroxydocosahexaenoic _ acid -LRB- 10,17S-DHDHA -RRB- , maresin-1 -LRB- MaR-1 -RRB- and 14-hydroxydocosahexaenoic_acid -LRB- 14-HDHA -RRB- derived from docosahexaenoic_acid -LRB- DHA -RRB- . 15744015 1 10-17_selenocysteines 217,238 Selenoprotein_P 57,72 10-17 selenocysteines Selenoprotein P null 20363(Tax:10090) Chemical Gene contains|xcomp|START_ENTITY member|acl:relcl|contains member|nsubj|END_ENTITY Selenoprotein_P -LRB- SEPP1 -RRB- , an extracellular glycoprotein of unknown function , is a unique member of the selenoprotein family that , depending on species , contains 10-17_selenocysteines in its primary structure ; in contrast , all other family members contain a single selenocysteine residue . 15744015 1 10-17_selenocysteines 217,238 SEPP1 74,79 10-17 selenocysteines SEPP1 null 20363(Tax:10090) Chemical Gene contains|xcomp|START_ENTITY member|acl:relcl|contains member|nsubj|Selenoprotein_P Selenoprotein_P|appos|END_ENTITY Selenoprotein_P -LRB- SEPP1 -RRB- , an extracellular glycoprotein of unknown function , is a unique member of the selenoprotein family that , depending on species , contains 10-17_selenocysteines in its primary structure ; in contrast , all other family members contain a single selenocysteine residue . 26019148 3 10-18_carbons 504,517 FAA1 531,535 10-18 carbons FAA1 null 854495(Tax:4932) Chemical Gene n-alkanes|nmod|START_ENTITY decreased|nmod|n-alkanes decreased|advcl|showed showed|nsubj|mutant mutant|compound|END_ENTITY The FAT1 deletion mutant exhibited decreased growth on n-alkanes of 10-18_carbons , whereas the FAA1 mutant showed growth reduction on n-alkane_of_16_carbons . 26019148 3 10-18_carbons 504,517 FAT1 440,444 10-18 carbons FAT1 null 852329(Tax:4932) Chemical Gene n-alkanes|nmod|START_ENTITY decreased|nmod|n-alkanes decreased|nsubj|exhibited exhibited|compound|END_ENTITY The FAT1 deletion mutant exhibited decreased growth on n-alkanes of 10-18_carbons , whereas the FAA1 mutant showed growth reduction on n-alkane_of_16_carbons . 7417479 1 10-18_carbons 147,160 serum_albumin 218,231 10-18 carbons serum albumin null 213 Chemical Gene START_ENTITY|conj|END_ENTITY The binding of lysophosphatidylcholines containing 10-18_carbons and , with 18 carbon series , up to three double bonds , to serum_albumin was studied by heat-burst microcalorimetry . 19041090 4 101_PCB 719,726 PCB 686,689 101 PCB PCB MESH:C009828 5091 Chemical Gene congeners|nummod|START_ENTITY estimated|nmod|congeners estimated|nsubjpass|burden burden|compound|END_ENTITY PCB body burden was estimated by 101_PCB congeners and neuropsychological functioning was assessed by a battery of 18 tests . 18654638 10 10-20_amino_acids 1537,1554 GAP-43 1518,1524 10-20 amino acids GAP-43 null 2596 Chemical Gene containing|xcomp|START_ENTITY fragments|acl|containing fragments|nmod|END_ENTITY N-terminal fragments of GAP-43 , containing 10-20_amino_acids , will activate heterotrimeric G proteins , direct GAP-43 to the membrane and lipid rafts , and cause the formation of filopodia , possibly by causing a change in membrane tension . 18654638 10 10-20_amino_acids 1537,1554 GAP-43 1604,1610 10-20 amino acids GAP-43 null 2596 Chemical Gene containing|xcomp|START_ENTITY fragments|acl|containing activate|nsubj|fragments activate|conj|direct direct|dobj|END_ENTITY N-terminal fragments of GAP-43 , containing 10-20_amino_acids , will activate heterotrimeric G proteins , direct GAP-43 to the membrane and lipid rafts , and cause the formation of filopodia , possibly by causing a change in membrane tension . 17570371 5 1021-1652 854,863 OPG 697,700 1021-1652 OPG MESH:C036666 4982 Chemical Gene pg/mL|appos|START_ENTITY patients|dep|pg/mL higher|nmod|patients higher|nsubj|concentrations concentrations|compound|END_ENTITY OPG concentrations were higher in patients with long-standing RA -LRB- n = 67 -RRB- -LSB- median -LRB- interquartile range -RRB- -RSB- : -LSB- 1895 -LRB- 1337-2847 -RRB- pg/mL , and early RA -LRB- n = 90 -RRB- : -LSB- 1340 -LRB- 1021-1652 -RRB- pg/mL , than controls 1068 -LRB- 692-1434 -RRB- pg/mL ; -LRB- p < 0.001 -RRB- -RSB- . 16169633 7 10-23U 839,845 DPP_IV 828,834 10-23U DPP IV null 1803 Chemical Gene l|nummod|START_ENTITY l|nsubj|range range|nmod|END_ENTITY RESULTS : The reference range for DPP_IV was 10-23U / l -LRB- mean : 16.01 + / -3.2 -RRB- . 2656259 1 1024-amino-acid 215,230 HlyA 250,254 1024-amino-acid HlyA null 7701379(Tax:562) Chemical Gene protein|amod|START_ENTITY protein|appos|END_ENTITY We have studied the C-terminal signal which directs the complete export of the 1024-amino-acid hemolysin protein -LRB- HlyA -RRB- of Escherichia_coli across both bacterial membranes into the surrounding medium . 10423761 2 102_67Ga-citrate 350,366 SCC 433,436 102 67Ga-citrate SCC MESH:C103850 6317 Chemical Gene scans|amod|START_ENTITY performed|nsubjpass|scans performed|nmod|patients patients|nmod|END_ENTITY Altogether , 102_67Ga-citrate whole-body scans were performed on 83 patients with head and neck SCC using a dual-headed gamma camera . 11127865 8 1026G 893,898 FXI 870,873 1026G FXI MESH:C036630 2160 Chemical Gene mutation|appos|START_ENTITY mutation|compound|END_ENTITY The FXI splicing mutation , 1026G -- > T cd 324 , was found in compound heterozygosity with missense mutation FXI_K518N . 2136995 1 1031-1040 160,169 5-HT1A 193,199 1031-1040 5-HT1A MESH:C056494 24473(Tax:10116) Chemical Gene Neurochem|nummod|START_ENTITY Mestikawy|nmod|Neurochem investigations|dep|Mestikawy shown|nsubj|investigations shown|ccomp|modulated modulated|nsubjpass|sites sites|nummod|END_ENTITY Previous investigations -LRB- El Mestikawy et al. , J Neurochem 51 : 1031-1040 , 1988 -RRB- have shown that 5-HT1A binding sites -LRB- R -LSB- 5-HT1A -RSB- -RRB- solubilized by CHAPS from rat hippocampal membranes can be modulated by guanine_nucleotides , as expected from their solubilization together with associated G regulatory proteins -LRB- G -RRB- . 2136995 1 1031-1040 160,169 5-HT1A 217,223 1031-1040 5-HT1A MESH:C056494 24473(Tax:10116) Chemical Gene Neurochem|nummod|START_ENTITY Mestikawy|nmod|Neurochem investigations|dep|Mestikawy shown|nsubj|investigations shown|ccomp|modulated modulated|nsubjpass|sites sites|appos|-RSB- -RSB-|compound|END_ENTITY Previous investigations -LRB- El Mestikawy et al. , J Neurochem 51 : 1031-1040 , 1988 -RRB- have shown that 5-HT1A binding sites -LRB- R -LSB- 5-HT1A -RSB- -RRB- solubilized by CHAPS from rat hippocampal membranes can be modulated by guanine_nucleotides , as expected from their solubilization together with associated G regulatory proteins -LRB- G -RRB- . 12616822 8 103-232 1391,1398 CRP 1234,1237 103-232 CRP MESH:C016822 1401 Chemical Gene 136|appos|START_ENTITY group|conj|136 found|nmod|group found|nsubjpass|levels levels|compound|END_ENTITY Significantly lower CRP levels were found in the NAC group on day one and two -LSB- t24 : median : 84.5 interquartile range : -LRB- 62.48-120 .25 -RRB- vs. 118 -LRB- 86-137 -RRB- mg/l ; p = 0.020 ; t48 : 136 -LRB- 103-232 -RRB- vs. 195 -LRB- 154.5-252 -RRB- mg/l p = 0.013 , NAC vs. placebo -RSB- . 8961926 3 10325-10333 668,679 keratinocyte_growth_factor_receptor 444,479 10325-10333 keratinocyte growth factor receptor MESH:C066072 2263 Chemical Gene Biochemistry|nummod|START_ENTITY -RSB-|dep|Biochemistry A.|amod|-RSB- Gray|appos|A. specificity|nmod|Gray determining|dobj|specificity participate|advcl|determining participate|nsubj|loop loop|nmod|domain domain|nmod|END_ENTITY The F-G loop in the membrane proximal domain of the keratinocyte_growth_factor_receptor has previously been shown to participate in determining the FGF ligand binding specificity of KGFR -LSB- Gray , T. E. , Eisenstein , M. , Shimon , T. , Givol , D. , _ Yayon , A. -LRB- 1995 -RRB- Biochemistry 34 , 10325-10333 -RSB- . 8961926 3 10325-10333 668,679 KGFR 574,578 10325-10333 KGFR MESH:C066072 2263 Chemical Gene Biochemistry|nummod|START_ENTITY -RSB-|dep|Biochemistry A.|amod|-RSB- Gray|appos|A. Gray|compound|END_ENTITY The F-G loop in the membrane proximal domain of the keratinocyte_growth_factor_receptor has previously been shown to participate in determining the FGF ligand binding specificity of KGFR -LSB- Gray , T. E. , Eisenstein , M. , Shimon , T. , Givol , D. , _ Yayon , A. -LRB- 1995 -RRB- Biochemistry 34 , 10325-10333 -RSB- . 15450424 12 10347C 1698,1704 CYP2S1 1687,1693 10347C CYP2S1 null 29785 Chemical Gene -LSB-|nummod|START_ENTITY *|dep|-LSB- *|compound|END_ENTITY The respective allelic variants , CYP2S1 * 2 -LRB- -LSB- 10347C _ > _ T -RSB- -RRB- and CYP2S1 * 3 -LRB- 13106C _ > _ T ; 13255A _ > _ G -RSB- -RRB- , occurred in our study population at frequencies of 0.50 and 3.75 % , respectively . 15450424 12 10347C 1698,1704 CYP2S1 1715,1721 10347C CYP2S1 null 29785 Chemical Gene -LSB-|nummod|START_ENTITY *|dep|-LSB- *|conj|3 3|compound|END_ENTITY The respective allelic variants , CYP2S1 * 2 -LRB- -LSB- 10347C _ > _ T -RSB- -RRB- and CYP2S1 * 3 -LRB- 13106C _ > _ T ; 13255A _ > _ G -RSB- -RRB- , occurred in our study population at frequencies of 0.50 and 3.75 % , respectively . 1833637 4 1,035-amino-acid 686,702 CDC68 670,675 1,035-amino-acid CDC68 null 852665(Tax:4932) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|END_ENTITY CDC68 encodes a 1,035-amino-acid protein with a highly acidic and serine-rich carboxyl terminus . 16214042 4 1035-amino_acid 404,419 USP31 436,441 1035-amino acid USP31 MESH:C071737 57478 Chemical Gene isoform|amod|START_ENTITY isoform|nmod|END_ENTITY One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- . 16214042 4 1035-amino_acid 404,419 USP31 443,448 1035-amino acid USP31 MESH:C071737 57478 Chemical Gene isoform|amod|START_ENTITY isoform|nmod|USP31 END_ENTITY|appos|USP31 One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- . 16214042 4 1035-amino_acid 404,419 USP31S1 518,525 1035-amino acid USP31S1 MESH:C071737 57478 Chemical Gene isoform|amod|START_ENTITY isoform|conj|other other|dep|isoform isoform|appos|END_ENTITY One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- . 12842213 5 1039G 607,612 OPA1 593,597 1039G OPA1 null 4976 Chemical Gene _|nummod|START_ENTITY gene|dep|_ gene|compound|END_ENTITY RESULTS : Of the 12 patients , 2 had nonsense mutations of the OPA1 gene -LRB- nt 1039G _ -- > _ T and nt 1096C _ -- > _ T , leading to Glu347Stop and Arg366Stop , respectively -RRB- . 9680353 10 103B2/9E10 2077,2087 CD164 2071,2076 103B2/9E10 CD164 MESH:D004958 8763 Chemical Gene analyses|appos|START_ENTITY analyses|nmod|END_ENTITY Further analyses of the CD34 -LRB- lo / - -RRB- CD164 -LRB- 103B2/9E10 -RRB- + subsets indicated that one of the most prominent populations consists of maturing erythroid cells . 9680353 10 103B2/9E10 2077,2087 CD34 2061,2065 103B2/9E10 CD34 MESH:D004958 947 Chemical Gene analyses|appos|START_ENTITY analyses|nmod|CD164 CD164|compound|END_ENTITY Further analyses of the CD34 -LRB- lo / - -RRB- CD164 -LRB- 103B2/9E10 -RRB- + subsets indicated that one of the most prominent populations consists of maturing erythroid cells . 12799135 5 103_polyglutamine 892,909 Htt 867,870 103 polyglutamine Htt MESH:C097188 3064 Chemical Gene repeat|amod|START_ENTITY 25|conj|repeat expressing|nmod|25 expressing|dobj|exon exon|nmod|protein protein|appos|END_ENTITY To test this hypothesis , reporter gene assays were performed in inducible PC12 cell lines expressing exon 1 of the human huntingtin protein -LRB- Htt -RRB- with either a 25 or 103_polyglutamine -LRB- Q -RRB- repeat . 12799135 5 103_polyglutamine 892,909 huntingtin 847,857 103 polyglutamine huntingtin MESH:C097188 3064 Chemical Gene repeat|amod|START_ENTITY 25|conj|repeat expressing|nmod|25 expressing|dobj|exon exon|nmod|protein protein|compound|END_ENTITY To test this hypothesis , reporter gene assays were performed in inducible PC12 cell lines expressing exon 1 of the human huntingtin protein -LRB- Htt -RRB- with either a 25 or 103_polyglutamine -LRB- Q -RRB- repeat . 1288510 1 10405-02-4 185,195 CAS 181,184 10405-02-4 CAS MESH:C553544 9564 Chemical Gene END_ENTITY|nummod|START_ENTITY In a randomized double-blind study the effects of increasing doses of trospium_chloride -LRB- Spasmo-lyt , CAS 10405-02-4 -RRB- , 0.2 , 0.5 , 1.0 , and 1.5 mg i.v. , on gall-bladder_contractility were compared among themselves and against placebo and n-butylscopolamine_bromide -LRB- 20 mg i.v. -RRB- by an intraindividual 5-fold crossover technique . 11280720 3 104-123 666,673 protein_kinase_C_delta 592,614 104-123 protein kinase C delta MESH:C051848 5580 Chemical Gene sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|nmod|factor-I factor-I|acl|receptor-mediated receptor-mediated|xcomp|signaling signaling|advcl|vitro vitro|nmod|interaction interaction|nmod|END_ENTITY Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL . 11280720 3 104-123 666,673 pVHL 467,471 104-123 pVHL MESH:C051848 7428 Chemical Gene sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|dep|END_ENTITY Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL . 11280720 3 104-123 666,673 pVHL 701,705 104-123 pVHL MESH:C051848 7428 Chemical Gene sequence|appos|START_ENTITY sequence|nmod|beta-domain beta-domain|nmod|END_ENTITY Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL . 11280720 4 104-123 754,761 pVHL 770,774 104-123 pVHL MESH:C051848 7428 Chemical Gene sequence|appos|START_ENTITY sequence|nmod|END_ENTITY In the present study , the amino_acid sequence -LRB- 104-123 -RRB- of the pVHL was conjugated to the protein transduction domain of HIV-TAT protein -LRB- TATFLAGVHL-peptide -RRB- to facilitate entry into cells , and we demonstrate that this amino_acid region of VHL is sufficient to block proliferation and invasion of 786-O renal cancer cells in vitro . 11280720 3 104-123 666,673 VHL 449,452 104-123 VHL MESH:C051848 7428 Chemical Gene sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|nsubj|Reintroduction Reintroduction|nmod|product product|compound|END_ENTITY Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL . 11280720 4 104-123 754,761 VHL 947,950 104-123 VHL MESH:C051848 7428 Chemical Gene sequence|appos|START_ENTITY conjugated|nsubjpass|sequence conjugated|conj|demonstrate demonstrate|ccomp|sufficient sufficient|nsubj|region region|nmod|END_ENTITY In the present study , the amino_acid sequence -LRB- 104-123 -RRB- of the pVHL was conjugated to the protein transduction domain of HIV-TAT protein -LRB- TATFLAGVHL-peptide -RRB- to facilitate entry into cells , and we demonstrate that this amino_acid region of VHL is sufficient to block proliferation and invasion of 786-O renal cancer cells in vitro . 18950599 5 1042D 746,751 pfmdr1 732,738 1042D pfmdr1 null 813045(Tax:36329) Chemical Gene alleles|nummod|START_ENTITY 1042N|conj|alleles 1042N|amod|END_ENTITY The pfmdr1 1042N , 1042D alleles and a mixture -LRB- 1042N +1042 D -RRB- of the alleles were found in 94 -LRB- 85.5 % -RRB- , 12 -LRB- 10.9 % -RRB- and 4 -LRB- 3.6 % -RRB- isolates , respectively . 1898367 4 1043-amino-acid 903,918 valyl-tRNA_synthetase 957,978 1043-amino-acid valyl-tRNA synthetase null 7407 Chemical Gene overlap|amod|START_ENTITY overlap|nmod|END_ENTITY Comparison of the derived amino_acid sequence of the G7a protein with the National Biomedical Research Foundation protein databases revealed 42 % identity in a 250-amino-acid overlap with Bacillus_stearothermophilus valyl-tRNA_synthetase , 38.0 % identity in a 993-amino-acid overlap with Escherichia_coli valyl-tRNA_synthetase -LRB- val RS -RRB- , and 48.3 % identity in a 1043-amino-acid overlap with Saccharomyces_cerevisiae valyl-tRNA_synthetase . 26820066 10 1044-1051 1496,1505 CLUAP1 1408,1414 1044-1051 CLUAP1 MESH:C055611 23059 Chemical Gene report|dobj|START_ENTITY report|xcomp|linking linking|dobj|mutations mutations|nmod|END_ENTITY This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate LCA gene.Genet Med 18 10 , 1044-1051 . 26820066 10 1044-1051 1496,1505 CLUAP1 1448,1454 1044-1051 CLUAP1 MESH:C055611 23059 Chemical Gene report|dobj|START_ENTITY report|conj|establishes establishes|dobj|END_ENTITY This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate LCA gene.Genet Med 18 10 , 1044-1051 . 12186888 6 1,047-amino-acid 1106,1122 Ahi-1 1085,1090 1,047-amino-acid Ahi-1 null 52906(Tax:10090) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY The Ahi-1 cDNA encodes a 1,047-amino-acid protein . 12869526 1 1047-amino_acid 230,245 GEMIN4 146,152 1047-amino acid GEMIN4 MESH:C425326 50628 Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|HCAP1 HCAP1|appos|variant variant|nmod|END_ENTITY The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein . 12869526 1 1047-amino_acid 230,245 HCAP1 97,102 1047-amino acid HCAP1 MESH:C425326 50628 Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|END_ENTITY The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein . 12869526 1 1047-amino_acid 230,245 HCC-associated_Protein_1 104,128 1047-amino acid HCC-associated Protein 1 MESH:C425326 50628 Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|HCAP1 HCAP1|appos|END_ENTITY The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein . 15804288 3 1047-amino-acid 620,635 TLR7 600,604 1047-amino-acid TLR7 null 418638(Tax:9031) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY The chicken TLR7 gene encodes a 1047-amino-acid protein with 62 % identity to human TLR7 and a conserved pattern of predicted leucine-rich repeats . 15804288 3 1047-amino-acid 620,635 TLR7 671,675 1047-amino-acid TLR7 null 51284 Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nmod|identity identity|nmod|END_ENTITY The chicken TLR7 gene encodes a 1047-amino-acid protein with 62 % identity to human TLR7 and a conserved pattern of predicted leucine-rich repeats . 9115249 6 104-amino_acid 841,855 phospholipase_A2 871,887 104-amino acid phospholipase A2 MESH:C089163 406141(Tax:7460) Chemical Gene residues|amod|START_ENTITY subunit|appos|residues consists|nmod|subunit consists|nmod|activity activity|amod|END_ENTITY The IpTxi dimer consists of a large subunit -LRB- 104-amino_acid residues -RRB- with phospholipase_A2 -LRB- PLA2 -RRB- activity covalently linked by a disulfide bond to a smaller -LRB- 27 amino_acid residues -RRB- , structurally unrelated subunit . 9115249 6 104-amino_acid 841,855 PLA2 889,893 104-amino acid PLA2 MESH:C089163 406141(Tax:7460) Chemical Gene residues|amod|START_ENTITY subunit|appos|residues consists|nmod|subunit consists|nmod|activity activity|appos|END_ENTITY The IpTxi dimer consists of a large subunit -LRB- 104-amino_acid residues -RRB- with phospholipase_A2 -LRB- PLA2 -RRB- activity covalently linked by a disulfide bond to a smaller -LRB- 27 amino_acid residues -RRB- , structurally unrelated subunit . 6328158 9 10-4M 1447,1452 TRH 1492,1495 10-4M TRH MESH:D008775 25569(Tax:10116) Chemical Gene Atropine|appos|START_ENTITY abolished|nsubj|Atropine abolished|dobj|- -|appos|END_ENTITY Atropine -LRB- 10-4M -RRB- almost completely abolished DN-1417 - , _ TRH - and carbachol-induced cyclic_AMP formation in the presence and absence of pentobarbital . 9809072 7 1052-amino-acid 939,954 S1P 918,921 1052-amino-acid S1P MESH:C000591384 8720 Chemical Gene protease|amod|START_ENTITY END_ENTITY|appos|protease The cDNA encodes S1P , an intraluminal 1052-amino-acid membrane-bound subtilisin-like protease . 16584805 6 1053-1066 1048,1057 vinculin 995,1003 1053-1066 vinculin MESH:C519885 22330(Tax:10090) Chemical Gene residues|nummod|START_ENTITY arm|appos|residues lacking|dobj|arm used|xcomp|lacking used|dobj|mutant mutant|compound|END_ENTITY To investigate the role of the vinculin/PIP2 interaction in FA dynamics , we used a vinculin mutant lacking the C-terminal arm -LRB- residues 1053-1066 -RRB- and referred to as the deltaC mutation . 11244063 4 1,055-amino-acid 636,652 YEF3 722,726 1,055-amino-acid YEF3 null 850951(Tax:4932) Chemical Gene protein|amod|START_ENTITY encode|dobj|protein found|xcomp|encode found|conj|has has|dobj|identity identity|appos|END_ENTITY CnEF3 was found to encode a 1,055-amino-acid protein and has 44 % identity with EF3 from Saccharomyces_cerevisiae -LRB- YEF3 -RRB- . 26045558 3 1058-1062 491,500 Pax6 318,322 1058-1062 Pax6 MESH:C059545 5080 Chemical Gene Nature|nummod|START_ENTITY A.|dep|Nature Mass|conj|A. mice|dep|Mass phenotype|nmod|mice humans|conj|phenotype cause|nmod|humans cause|nsubj|Defects Defects|nmod|END_ENTITY Defects in Pax6 cause aniridia_and_LSC_deficiency in humans and the Sey -LRB- Small eye -RRB- phenotype in mice -LRB- Mass , K. , Bhamra , S. , Eason , R. , Dale , N. , and Jones , E. A. -LRB- 2007 -RRB- Nature 449 , 1058-1062 -RRB- . 8752124 1 105-amino-acid 154,168 CT105 179,184 105-amino-acid CT105 null 884093(Tax:272561) Chemical Gene fragment|amod|START_ENTITY fragment|appos|END_ENTITY We have previously shown that a recombinant carboxyl-terminal 105-amino-acid fragment -LRB- CT105 -RRB- of the amyloid precursor protein -LRB- APP -RRB- induced strong non-selective inward currents in Xenopus oocytes . 8242252 13 10-5M 1974,1979 ET-1 1906,1910 10-5M ET-1 MESH:D008775 24323(Tax:10116) Chemical Gene BQ-123|appos|START_ENTITY antagonized|nmod|BQ-123 antagonized|nsubj|effects effects|nmod|END_ENTITY These direct effects of ET-1 or SX6b were strongly antagonized -LRB- 100 fold -RRB- by either BQ-123 -LRB- 10-5M -RRB- or PD 142893 -LRB- 10-5_M -RRB- . 6328158 4 10-5M 735,740 TRH 745,748 10-5M TRH MESH:D008775 25569(Tax:10116) Chemical Gene DN-1417|appos|START_ENTITY DN-1417|conj|END_ENTITY A concomitant application of DN-1417 -LRB- 10-5M -RRB- or TRH -LRB- 10-4M -RRB- and pentobarbital -LRB- 5 x 10-4M -RRB- led to a partial recovery of the pentobarbital effect . 8032583 15 10-5_M 1503,1509 ET-1 1585,1589 10-5 M ET-1 MESH:D008775 100726197 Chemical Gene BQ-123|appos|START_ENTITY had|nsubj|BQ-123 had|nmod|epithelium epithelium|acl|induced induced|nmod|END_ENTITY BQ-123 -LRB- 10-5_M -RRB- had no effect on contractions of the trachea without epithelium induced by ET-1 , but FR139317 -LRB- 10-5_M -RRB- caused a significant inhibition . 8032583 21 10-5_M 2460,2466 ET-1 2378,2382 10-5 M ET-1 MESH:D008775 100726197 Chemical Gene BQ-123|appos|START_ENTITY attenuated|nmod|BQ-123 was|conj|attenuated was|nsubj|action action|nmod|END_ENTITY The contractile action of ET-1 in the lung parenchyma was significantly and similarly attenuated by BQ-123 -LRB- 10-5_M -RRB- or indomethacin -LRB- 10-5_M -RRB- , while FRI39317 -LRB- 10-5_M -RRB- was less effective . 10594403 10 10-6-10-4_M 1289,1300 gastrin 1312,1319 10-6-10-4 M gastrin MESH:C052091 100345451(Tax:9986) Chemical Gene dimaprit|appos|START_ENTITY increased|nsubj|dimaprit increased|dobj|release release|compound|END_ENTITY The histamine H2-receptor agonist dimaprit -LRB- 10-6-10-4_M -RRB- increased gastrin release from 2.4 + / - 0.2 % to 3.6 + / - 0.2 % TCC -LRB- P < 0.001 -RRB- . 10594403 7 10-6-10-4_M 819,830 gastrin 868,875 10-6-10-4 M gastrin MESH:C052091 100345451(Tax:9986) Chemical Gene NalphaMH|appos|START_ENTITY NalphaMH|acl:relcl|caused caused|nmod|release release|compound|END_ENTITY RESULTS : NalphaMH -LRB- 10-6-10-4_M -RRB- caused a dose-dependent increase in gastrin release from a basal level of 2.3 + / - 0.2 % total cell content -LRB- TCC ; mean + / - S.E.M. -RRB- to a maximum of 5.1 + / - 0.7 % , an increase of 117 % -LRB- P < 0 . 17301166 3 106-126 617,624 PrP 520,523 106-126 PrP MESH:C077829 19122(Tax:10090) Chemical Gene START_ENTITY|nmod|END_ENTITY We investigated the biological activity of PrP 82-146 and of two nonamyloidogenic variants of PrP 82-146 with scrambled amino_acid sequence 106-126 or 127-146 . 17301166 3 106-126 617,624 PrP 571,574 106-126 PrP MESH:C077829 19122(Tax:10090) Chemical Gene START_ENTITY|conj|variants variants|nmod|END_ENTITY We investigated the biological activity of PrP 82-146 and of two nonamyloidogenic variants of PrP 82-146 with scrambled amino_acid sequence 106-126 or 127-146 . 15642460 1 106-137 98,105 CAP18 92,97 106-137 CAP18 MESH:C004219 820 Chemical Gene END_ENTITY|appos|START_ENTITY Five peptides : BPI -LRB- 85-109 -RRB- ; CAP18 -LRB- 106-137 -RRB- ; endotoxin inhibitor -LRB- EI -RRB- ; GQ33 and GQ33C , derived from lipopolysaccharide -LRB- LPS -RRB- - binding molecules were investigated for LPS-binding ability with a view to a potential use in extracorporeal therapy . 15642460 5 106-137 695,702 CAP18 689,694 106-137 CAP18 MESH:C004219 820 Chemical Gene peptide|appos|START_ENTITY peptide|compound|END_ENTITY The CAP18 -LRB- 106-137 -RRB- peptide , which exhibited the highest binding efficacy and binding stability , was also immobilized on a poly -LRB- ethylene_imine -RRB- - poly -LRB- ethylene_glycol -RRB- -LRB- PEI-PEG -RRB- surface through maleimide-terminal_PEG . 15642460 6 106-137 934,941 CAP18 928,933 106-137 CAP18 MESH:C004219 820 Chemical Gene peptide|appos|START_ENTITY peptide|compound|END_ENTITY The binding efficacy of the CAP18 -LRB- 106-137 -RRB- peptide was not significantly affected by the different immobilization methods used in the attachment to a dextran or a PEI-PEG_surface . 15642460 7 106-137 1111,1118 CAP18 1105,1110 106-137 CAP18 MESH:C004219 820 Chemical Gene END_ENTITY|appos|START_ENTITY LPS bound selectively to CAP18 -LRB- 106-137 -RRB- and showed very low unspecific binding to the PEI-PEG_surface layer . 9056004 0 106-137 47,54 CAP18 41,46 106-137 CAP18 MESH:C004219 100009142(Tax:9986) Chemical Gene END_ENTITY|appos|START_ENTITY Antimicrobial action of rabbit leukocyte CAP18 -LRB- 106-137 -RRB- . 9056004 1 106-137 202,209 CAP18 196,201 106-137 CAP18 MESH:C004219 100009142(Tax:9986) Chemical Gene END_ENTITY|appos|START_ENTITY CAP18 is a cationic antimicrobial protein originally isolated from rabbit neutrophils , of which a 32-mer sequence from its C-terminal and -LRB- CAP18 -LRB- 106-137 -RRB- -RRB- has been found to be the most active . 9056004 1 106-137 202,209 CAP18 57,62 106-137 CAP18 MESH:C004219 100009142(Tax:9986) Chemical Gene CAP18|appos|START_ENTITY found|nsubjpass|CAP18 neutrophils|acl:relcl|found isolated|nmod|neutrophils protein|acl|isolated protein|nsubj|END_ENTITY CAP18 is a cationic antimicrobial protein originally isolated from rabbit neutrophils , of which a 32-mer sequence from its C-terminal and -LRB- CAP18 -LRB- 106-137 -RRB- -RRB- has been found to be the most active . 9056004 6 106-137 1609,1616 CAP18 1603,1608 106-137 CAP18 MESH:C004219 100009142(Tax:9986) Chemical Gene END_ENTITY|appos|START_ENTITY We conclude that CAP18 -LRB- 106-137 -RRB- exerts a rapid and profound action on E. _ coli cytoplasmic membranes and viability as measured by colony formation . 19050042 4 1062-amino-acid 460,475 Inv 441,444 1062-amino-acid Inv null 16348(Tax:10090) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY The mouse Inv gene encodes a 1062-amino-acid protein that is localized in primary cilia . 1709157 2 1066-amino_acid 111,126 Vinculin 97,105 1066-amino acid Vinculin MESH:C519885 7414 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY Vinculin is a 1066-amino_acid protein found at several types of actin-membrane junction . 18203193 9 1067G 1177,1182 ACVR1 1133,1138 1067G ACVR1 null 90 Chemical Gene A|nummod|START_ENTITY mutation|nsubj|A suggested|ccomp|mutation suggested|nsubj|Typing Typing|nmod|SNPs SNPs|acl|located located|nmod|region region|acl|spanning spanning|dobj|END_ENTITY Typing of SNPs located in the approximately 0.5-Mb region spanning ACVR1 and its neighbor genes suggested that 1067G _ > _ A is a de novo mutation . 16225879 5 1068H 724,729 ABCA1 945,950 1068H ABCA1 null 19 Chemical Gene alleles|nummod|START_ENTITY Haplotyping|nmod|alleles showed|nsubj|Haplotyping reported|ccomp|showed reported|xcomp|associated associated|nmod|expression expression|compound|END_ENTITY Haplotyping of both 1068H alleles in the proband showed homozygosity in the coding region , however , the maternal 1068H allele had three single nucleotide polymorphisms -LRB- SNPs -RRB- in the promoter previously reported to be associated with reduced ABCA1 expression and HDL levels . 10527855 4 106-amino-acid 648,662 CRM1 610,614 106-amino-acid CRM1 MESH:C588327 7514 Chemical Gene region|amod|START_ENTITY 81|conj|region binds|nmod|81 binds|nsubj|END_ENTITY CRM1 binds specifically to the 81 - to 106-amino-acid -LRB- aa -RRB- region of NS2 , and the region of NS2 actually functions as a NES . 15504869 5 106-amino-acid 710,724 PMP-1 685,690 106-amino-acid PMP-1 MESH:C588327 5824 Chemical Gene precursor|amod|START_ENTITY translated|nmod|precursor translated|nsubjpass|END_ENTITY PMP-1 is translated as a 106-amino-acid precursor and is processed to yield 73-residue -LRB- 8,053 Da -RRB- and 72-residue -LRB- 7,951-Da -RRB- variants . 11920196 6 106-amino-acid 1072,1086 Spna1 942,947 106-amino-acid Spna1 null 20739(Tax:10090) Chemical Gene structure|amod|START_ENTITY shows|dobj|structure sequence|acl:relcl|shows deduced|dobj|sequence reveals|ccomp|deduced reveals|nsubj|Sequencing Sequencing|nmod|region region|nmod|allele allele|amod|END_ENTITY Sequencing of the full length coding region of the Spna1 wild type allele from the C57BL/6J strain of mice reveals a 2414 residue deduced amino_acid sequence that shows the typical 106-amino-acid repeat structure previously described for other members of the spectrin protein family . 10594403 11 10-7-10-4_M 1429,1440 Gastrin 1379,1386 10-7-10-4 M Gastrin MESH:C040211 100345451(Tax:9986) Chemical Gene histamine|appos|START_ENTITY stimulated|nmod|histamine stimulated|nsubjpass|release release|compound|END_ENTITY Gastrin release was also stimulated by histamine -LRB- 10-7-10-4_M -RRB- from a basal value of 3.0 + / - 0.3 % to 5.4 + / - 0.5 % TCC -LRB- P < 0.001 -RRB- . 1306984 0 107-111 43,50 parathyroid_hormone-related_peptide 6,41 107-111 parathyroid hormone-related peptide MESH:C071784 19227(Tax:10090) Chemical Gene -|appos|START_ENTITY -|amod|END_ENTITY Human parathyroid_hormone-related_peptide - -LRB- 107-111 -RRB- does not inhibit bone resorption in neonatal mouse calvariae . 9611193 11 1071-amino-acid 1214,1229 Prp16 1230,1235 1071-amino-acid Prp16 MESH:C000596159 853961(Tax:4932) Chemical Gene protein|amod|START_ENTITY protein|amod|END_ENTITY Deletion analysis of the 1071-amino-acid Prp16 protein revealed that the N-terminal 204 amino_acids and the C-terminal 100 residues were dispensable for PRP16 function in vivo . 9611193 11 1071-amino-acid 1214,1229 PRP16 1342,1347 1071-amino-acid PRP16 MESH:C000596159 853961(Tax:4932) Chemical Gene protein|amod|START_ENTITY analysis|nmod|protein revealed|nsubj|analysis revealed|ccomp|dispensable dispensable|nmod|function function|nummod|END_ENTITY Deletion analysis of the 1071-amino-acid Prp16 protein revealed that the N-terminal 204 amino_acids and the C-terminal 100 residues were dispensable for PRP16 function in vivo . 19103596 3 1075AAAQN1079 880,893 AE2 847,850 1075AAAQN1079 AE2 MESH:C042264 6522 Chemical Gene 1075AAAQ1078|conj|START_ENTITY mutants|dep|1075AAAQ1078 RL1|amod|mutants RL1|compound|END_ENTITY AE2 RL1 mutants 1075AAAQ1078 and 1075AAAQN1079 showed reduced pHi sensitivity and pHo sensitivity was acid-shifted by approximately 1 pH unit . 19103596 3 1075AAAQN1079 880,893 pHi 909,912 1075AAAQN1079 pHi MESH:C042264 2821 Chemical Gene 1075AAAQ1078|conj|START_ENTITY mutants|dep|1075AAAQ1078 RL1|amod|mutants showed|nsubj|RL1 showed|ccomp|acid-shifted acid-shifted|nsubjpass|sensitivity sensitivity|compound|END_ENTITY AE2 RL1 mutants 1075AAAQ1078 and 1075AAAQN1079 showed reduced pHi sensitivity and pHo sensitivity was acid-shifted by approximately 1 pH unit . 12632087 11 1077-amino-acid 1236,1251 DAAM1 1352,1357 1077-amino-acid DAAM1 null 23002 Chemical Gene protein|amod|START_ENTITY protein|nmod|FH1 FH1|acl:relcl|showed showed|dobj|identity identity|nmod|END_ENTITY DAAM2 was a 1077-amino-acid protein with Formin-homology FH1 and FH2 domains , which showed 68.9 % total-amino-acid identity with DAAM1 . 12632087 11 1077-amino-acid 1236,1251 DAAM2 1224,1229 1077-amino-acid DAAM2 null 23500 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY DAAM2 was a 1077-amino-acid protein with Formin-homology FH1 and FH2 domains , which showed 68.9 % total-amino-acid identity with DAAM1 . 9920407 1 1078-amino-acid 90,105 calcium-sensing_receptor 53,77 1078-amino-acid calcium-sensing receptor null 846 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY The human calcium-sensing_receptor -LRB- CaSR -RRB- is a 1078-amino-acid cell surface protein which is expressed in the parathyroids , thyroid cells and the kidney , and is a member of the family of G protein-coupled receptors . 9920407 1 1078-amino-acid 90,105 CaSR 79,83 1078-amino-acid CaSR null 846 Chemical Gene protein|amod|START_ENTITY protein|nsubj|calcium-sensing_receptor calcium-sensing_receptor|appos|END_ENTITY The human calcium-sensing_receptor -LRB- CaSR -RRB- is a 1078-amino-acid cell surface protein which is expressed in the parathyroids , thyroid cells and the kidney , and is a member of the family of G protein-coupled receptors . 20589758 4 107-amino-acid 546,560 CTCF 571,575 107-amino-acid CTCF null 10664 Chemical Gene domain|amod|START_ENTITY domain|nmod|region region|nmod:poss|END_ENTITY Using transient and integrated reporters , we identified a 107-amino-acid domain in CTCF 's N-terminal region that is capable of transcriptional activation and chromatin decondensation . 3316983 8 107-kilodalton 1244,1258 SSN6 1207,1211 107-kilodalton SSN6 MESH:C415942 852410(Tax:4932) Chemical Gene protein|amod|START_ENTITY encode|dobj|protein predicted|xcomp|encode END_ENTITY|acl:relcl|predicted We also determined the nucleotide sequence of SSN6 , which is predicted to encode a 107-kilodalton protein with stretches of polyglutamine and poly -LRB- glutamine-alanine -RRB- . 12807786 4 1080-amino-acid 541,556 Lr21 508,512 1080-amino-acid Lr21 null 100125728(Tax:4565) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein spans|conj|encodes spans|nsubj|END_ENTITY Lr21 spans 4318 bp and encodes a 1080-amino-acid protein containing a conserved nucleotide-binding site -LRB- NBS -RRB- domain , 13 imperfect leucine-rich repeats -LRB- LRRs -RRB- , and a unique 151-amino-acid sequence missing from known NBS-LRR proteins at the N terminus . 22796424 5 1081-amino-acid 538,553 Drosha 516,522 1081-amino-acid Drosha null 29102 Chemical Gene peptide|amod|START_ENTITY encoded|dobj|peptide encoded|nsubj|gene gene|compound|END_ENTITY The sequence analysis revealed that the shrimp Drosha gene encoded a 1081-amino-acid peptide , which comprised two tandem ribonuclease III C terminal domains and a double-stranded RNA binding motif . 19740703 7 1082-1G 899,906 PCFT 925,929 1082-1G PCFT MESH:C049454 113235 Chemical Gene >|nummod|START_ENTITY homozygous|dep|> homozygous|dep|found found|nsubjpass|mutation mutation|nmod|gene gene|amod|END_ENTITY A homozygous 1082-1G > A mutation of the PCFT gene was found , resulting in skipping of exon 3 . 16210052 10 10841C 1445,1451 IL-12B 1561,1567 10841C IL-12B null 3593 Chemical Gene A|nummod|START_ENTITY affects|nsubj|A affects|conj|enhances enhances|dobj|level level|nmod|END_ENTITY Furthermore , 10841C _ > _ A affects the stability of transcripts , and promoter variant -6415 GC enhances the transcriptional level of IL-12B . 10702296 3 1085-nucleotide 445,460 transaldolase 620,633 1085-nucleotide transaldolase MESH:D009711 6888 Chemical Gene transcript|amod|START_ENTITY contained|nsubj|transcript contained|xcomp|oriented oriented|nmod|direction direction|nmod|transcription transcription|nmod|gene gene|amod|END_ENTITY A dominant 1085-nucleotide long transcript , TARE-6 , contained two adjacent Alu elements , a right monomer and a complete dimer , oriented opposite to the direction of transcription of the transaldolase gene . 9722942 5 1086_amino_acids 725,741 SOLH 709,713 1086 amino acids SOLH MESH:C108687 6650 Chemical Gene protein|nmod|START_ENTITY protein|compound|END_ENTITY The encoded SOLH protein of 1086_amino_acids has strong similarity to the D. _ melanogaster protein . 16961934 6 1086_amino_acids 1027,1043 TERT 981,985 1086 amino acids TERT MESH:C108687 7015 Chemical Gene protein|nmod|START_ENTITY encodes|dobj|protein cDNA|acl:relcl|encodes cDNA|compound|END_ENTITY We have cloned and characterized a 3261-bp full-length TERT cDNA , omTERT , which encodes a protein of 1086_amino_acids . 16121037 1 1086-amino_acids 338,354 KCC1 263,267 1086-amino acids KCC1 null 20498(Tax:10090) Chemical Gene polypeptide|nmod|START_ENTITY encoding|dobj|polypeptide cloned|xcomp|encoding cloned|advcl|exhibiting exhibiting|nmod|cDNAs cDNAs|compound|END_ENTITY Sheep K-Cl cotransporter-1 -LRB- shKCC1 -RRB- cDNA was cloned from kidney by RT-PCR with an open reading frame of 3258 base pairs exhibiting 92 % , 90 % , 88 % and 87 % identity with pig , rabbit and human , rat and mouse KCC1 cDNAs , respectively , encoding an approximately 122 kDa polypeptide of 1086-amino_acids . 15602741 2 1,087-nucleotide 855,871 Patients_C1I_and_C1S 741,761 1,087-nucleotide Patients C1I and C1S null 716 Chemical Gene sequence|amod|START_ENTITY %|nmod|sequence identity|nmod|% shared|dobj|identity C2I|acl|shared those|nmod|C2I reported|nsubj|those isolates|conj|reported isolates|nmod|END_ENTITY The HCV isolates from Patients_C1I_and_C1S and those from Patients C2I and C2S shared identity of 99.9 % and 99.1 % , respectively , in the 1,087-nucleotide -LRB- nt -RRB- sequence of the NS5B region , although these four isolates were only 91.7 % -96.2 % identical to the 94 reported genotype 1b isolates including those from Japanese patients . 1522152 4 1089_amino_acids 753,769 PSE-1 646,651 1089 amino acids PSE-1 MESH:C078903 855356(Tax:4932) Chemical Gene containing|dobj|START_ENTITY located|xcomp|containing located|nsubjpass|gene gene|compound|END_ENTITY The PSE-1 gene is located on chromosome XII of the yeast genome and codes for a hydrophobic protein containing 1089_amino_acids . 16725058 5 108-amino-acid 813,827 UNC-69 775,781 108-amino-acid UNC-69 MESH:C072528 176444(Tax:6239) Chemical Gene protein|amod|START_ENTITY identify|nmod|protein identify|dobj|END_ENTITY We identify UNC-69 as an evolutionarily conserved 108-amino-acid protein with a short coiled-coil domain . 15201812 4 10-8_M_testosterone 764,783 AhR 665,668 10-8 M testosterone AhR MESH:D013739 11622(Tax:10090) Chemical Gene vehicle|conj|START_ENTITY vitro|nmod|vehicle incubated|advcl|vitro removed|conj|incubated removed|nmod|WT WT|conj|END_ENTITY MATERIALS AND METHODS : UGSs were removed from WT and AhR null mutant -LRB- AhRKO -RRB- male C57BL/6 mice on gestation day 14 and incubated in vitro with vehicle , 10-8_M_testosterone or 10-8_M_testosterone plus 10-9 M TCDD for 5 days . 20110366 3 10902-10910 433,444 ceramide_synthase_2 465,484 10902-10910 ceramide synthase 2 MESH:C086698 76893(Tax:10090) Chemical Gene 285|amod|START_ENTITY 285|amod|due due|nmod|ablation ablation|nmod|END_ENTITY 285 , 10902-10910 -RRB- due to ablation of ceramide_synthase_2 -LRB- CerS2 -RRB- . 20110366 3 10902-10910 433,444 CerS2 486,491 10902-10910 CerS2 MESH:C086698 76893(Tax:10090) Chemical Gene 285|amod|START_ENTITY 285|amod|due due|nmod|ablation ablation|nmod|ceramide_synthase_2 ceramide_synthase_2|appos|END_ENTITY 285 , 10902-10910 -RRB- due to ablation of ceramide_synthase_2 -LRB- CerS2 -RRB- . 20682279 4 109-123 561,568 SOD1 536,540 109-123 SOD1 MESH:C050088 6647 Chemical Gene residues|conj|START_ENTITY END_ENTITY|dep|residues From our study of a panel of mutant proteins , we identify two sequence elements in human SOD1 -LRB- residues 42-50 and 109-123 -RRB- that are critical in modulating the aggregation of the protein . 11232017 5 109-141 673,680 PTHrP 685,690 109-141 PTHrP MESH:C097725 5744 Chemical Gene carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal antibodies|nmod|END_ENTITY Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line . 11232017 5 109-141 673,680 PTHrP 722,727 109-141 PTHrP MESH:C097725 5744 Chemical Gene carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal identify|nsubj|antibodies identify|dobj|END_ENTITY Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line . 11232017 5 109-141 673,680 PTHrP 741,746 109-141 PTHrP MESH:C097725 5744 Chemical Gene carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal used|nsubjpass|antibodies used|conj|secreted secreted|dobj|END_ENTITY Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line . 11232017 5 109-141 673,680 PTHrP 811,816 109-141 PTHrP MESH:C097725 5744 Chemical Gene carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal used|nsubjpass|antibodies used|conj|secreted secreted|dobj|PTHrP PTHrP|nmod|Western Western|conj|staining staining|nmod|END_ENTITY Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line . 8977313 9 109203X 1807,1814 Apo-1 1906,1911 109203X Apo-1 null 355 Chemical Gene GF|nummod|START_ENTITY inhibited|nsubj|GF inhibited|nmod|apoptosis apoptosis|amod|/ /|amod|END_ENTITY Furthermore , the bis-indolylmaleimide GF 109203X , a specific inhibitor of PKC , inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1 / Fas-induced apoptosis . 8977313 9 109203X 1807,1814 IFN-alpha2 1892,1902 109203X IFN-alpha2 null 3440 Chemical Gene GF|nummod|START_ENTITY inhibited|nsubj|GF inhibited|dobj|effect effect|conj|that that|nmod|END_ENTITY Furthermore , the bis-indolylmaleimide GF 109203X , a specific inhibitor of PKC , inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1 / Fas-induced apoptosis . 3500169 6 1094-1099 862,871 s-mephenytoin_4-hydroxylase 739,766 1094-1099 s-mephenytoin 4-hydroxylase MESH:C045621 1557 Chemical Gene Biochemistry|nummod|START_ENTITY P.|dep|Biochemistry Umbenhauer|conj|P. END_ENTITY|dep|Umbenhauer The human P-450 1 is 82 % homologous to the s-mephenytoin_4-hydroxylase -LRB- Umbenhauer , D. R. , Martin , M. V. , Lloyd , R. S. , and Guengerich , F. P. -LRB- 1987 -RRB- Biochemistry 26 , 1094-1099 -RRB- . 15137909 3 1095-1106 739,748 AD1 813,816 1095-1106 AD1 MESH:C121396 351 Chemical Gene -RSB-|nsubj|START_ENTITY -RSB-|nmod|domain domain|appos|END_ENTITY Here , we identified two CBP-interacting sites -LSB- amino_acids_1075-1083 -LRB- site I -RRB- and 1095-1106 -LRB- site II -RRB- -RSB- in a so-called CBP-dependent transactivation domain -LRB- AD1 ; amino acids_1057-1109 -RRB- of GRIP1 . 15137909 3 1095-1106 739,748 GRIP1 844,849 1095-1106 GRIP1 MESH:C121396 10499 Chemical Gene -RSB-|nsubj|START_ENTITY -RSB-|nmod|domain domain|nmod|END_ENTITY Here , we identified two CBP-interacting sites -LSB- amino_acids_1075-1083 -LRB- site I -RRB- and 1095-1106 -LRB- site II -RRB- -RSB- in a so-called CBP-dependent transactivation domain -LRB- AD1 ; amino acids_1057-1109 -RRB- of GRIP1 . 15897884 2 1098-amino-acid 463,478 MYO1F 397,402 1098-amino-acid MYO1F null 4542 Chemical Gene domains|amod|START_ENTITY encode|dobj|domains predicted|xcomp|encode consists|conj|predicted consists|nsubj|END_ENTITY MYO1F consists of at least 28 exons and was predicted to encode a 1098-amino-acid with an N-terminal head domain containing both ATP-binding and actin-binding sequences , a neck domain with a single IQ motif , and a tail with TH1 , TH2 and SH3 domains . 15897884 2 1098-amino-acid 463,478 TH1 621,624 1098-amino-acid TH1 null 51497 Chemical Gene START_ENTITY|nmod|domain domain|acl|containing containing|dobj|ATP-binding ATP-binding|conj|tail tail|nmod|END_ENTITY MYO1F consists of at least 28 exons and was predicted to encode a 1098-amino-acid with an N-terminal head domain containing both ATP-binding and actin-binding sequences , a neck domain with a single IQ motif , and a tail with TH1 , TH2 and SH3 domains . 12410208 1 109AGC 340,346 carnitine_palmitoyltransferase_II 218,251 109AGC carnitine palmitoyltransferase II null 1376 Chemical Gene _|nummod|START_ENTITY Q413fs|conj|_ mutations|dep|Q413fs heterozygosity|nmod|mutations deficiency|nmod|heterozygosity deficiency|amod|END_ENTITY We describe a lethal neonatal form of carnitine_palmitoyltransferase_II -LRB- CPT_II -RRB- deficiency with compound heterozygosity for 2 truncation mutations -LRB- Q413fs and 109AGC _ -- > _ GCAGC -RRB- . 12410208 1 109AGC 340,346 CPT_II 253,259 109AGC CPT II null 1376 Chemical Gene _|nummod|START_ENTITY Q413fs|conj|_ mutations|dep|Q413fs heterozygosity|nmod|mutations deficiency|nmod|heterozygosity deficiency|appos|END_ENTITY We describe a lethal neonatal form of carnitine_palmitoyltransferase_II -LRB- CPT_II -RRB- deficiency with compound heterozygosity for 2 truncation mutations -LRB- Q413fs and 109AGC _ -- > _ GCAGC -RRB- . 1649341 3 109-amino-acid 682,696 gp70 618,622 109-amino-acid gp70 null 133418 Chemical Gene region|amod|START_ENTITY achieved|nmod|region depended|conj|achieved depended|nmod|region region|nmod|terminus terminus|nmod|gene gene|amod|END_ENTITY T-cell killing depended on changes within a 7-amino-acid region near the C terminus of the gp70 env gene or was achieved independently by changes within a 109-amino-acid region encompassing the N terminus of gp70 . 1649341 3 109-amino-acid 682,696 gp70 735,739 109-amino-acid gp70 null 133418 Chemical Gene region|amod|START_ENTITY region|acl|encompassing encompassing|dobj|terminus terminus|nmod|END_ENTITY T-cell killing depended on changes within a 7-amino-acid region near the C terminus of the gp70 env gene or was achieved independently by changes within a 109-amino-acid region encompassing the N terminus of gp70 . 7236494 2 109CdCl2 801,809 Cd2 824,827 109CdCl2 Cd2 null 497761(Tax:10116) Chemical Gene studies|nmod|START_ENTITY revealed|nsubj|studies revealed|ccomp|distributed distributed|nsubjpass|+ +|compound|END_ENTITY Autoradiographic studies with 109CdCl2 revealed that Cd2 + , accumulated by the kidney under these conditions , was not uniformly distributed throughout the renal cortex , but was concentrated unevenly in proximal tubules in the outer stripe of the outer zone of the medulla . 7570600 1 109CdCl2 261,269 Cd-MT 165,170 109CdCl2 Cd-MT null 74256(Tax:10090) Chemical Gene injection|nmod|START_ENTITY examined|nmod|injection examined|nsubjpass|effects effects|nmod|erythropoiesis erythropoiesis|nmod|cadmium-metallothionein cadmium-metallothionein|appos|END_ENTITY The effects of erythropoiesis on cadmium-metallothionein -LRB- Cd-MT -RRB- 2 levels in spleen , a major erythropoietic tissue , was examined following sc injection of 109CdCl2 into mice . 16335400 3 109G 707,711 Cx26 645,649 109G Cx26 MESH:C420352 2706 Chemical Gene A|amod|START_ENTITY ,79|dep|A sequence|dep|,79 sequence|nmod|gene gene|amod|END_ENTITY RESULTS : Compared with the reference sequence of Cx26 gene , totally four kinds of nucleotide changes ,79 G _ -- > A , 109G -- > A , 341G -- > A and 235delC , were detected in a heterozygous form . 8102392 3 10-acetate 246,256 C-2 320,323 10-acetate C-2 null 717 Chemical Gene hydrolyzed|nsubjpass|START_ENTITY hydrolyzed|advcl|C-4_acetate C-4_acetate|conj|cyclohexylcarboxylate cyclohexylcarboxylate|compound|END_ENTITY The 10-acetate was hydrolyzed first , followed by the C-4_acetate and then the C-2 cyclohexylcarboxylate ; an explanation for this unexpected order is presented . 23167949 6 10-acetyl 1094,1103 C-10 1140,1144 10-acetyl C-10 null 3226 Chemical Gene substituent|amod|START_ENTITY substituent|nmod|position position|compound|END_ENTITY Bisulfite bonded to the carbonyl of 10-acetyl substituent instead of the expected C-10 position of the pyranoanthocyanin core , thus giving rise to a red pigment hypsochromically shifted toward orangish nuances -LRB- maximum absorbances at 487-491 nm -RRB- . 21902186 1 10-acetylirciformonin_B 211,234 C21 90,93 10-acetylirciformonin B C21 MESH:C562206 79718 Chemical Gene 15-acetylirciformonin_B|conj|START_ENTITY compounds|amod|15-acetylirciformonin_B ircinolin_A|conj|compounds product|appos|ircinolin_A product|amod|END_ENTITY One novel C21 terpenoidal natural product , ircinolin_A -LRB- 2 -RRB- , two new C22 furanoterpene metabolites , 15-acetylirciformonin_B -LRB- 3 -RRB- and 10-acetylirciformonin_B -LRB- 4 -RRB- , and two known compounds , irciformonin_B -LRB- 1 -RRB- and irciformonin_F -LRB- 5 -RRB- , were isolated from the sponge Ircinia sp . 3222264 0 10-acyl 129,136 glucose-6-phosphate_dehydrogenase 73,106 10-acyl glucose-6-phosphate dehydrogenase null 2539 Chemical Gene derivatives|amod|START_ENTITY inhibition|nmod|derivatives inhibition|compound|synthesis synthesis|conj|END_ENTITY -LSB- Senecioyldithranol and beta-carbethoxypropionyldithranol : synthesis and glucose-6-phosphate_dehydrogenase inhibition of two new 10-acyl derivatives of the antipsoriatic , dithranol -RSB- . 1123034 3 10-Acyl 407,414 VIII 455,459 10-Acyl VIII null 1351 Chemical Gene START_ENTITY|conj|10-beta-cyanoethyl 10-beta-cyanoethyl|dep|VII VII|dep|END_ENTITY 10-Acyl -LRB- III - VI -RRB- and 10-beta-cyanoethyl -LRB- VII , VIII -RRB- derivatives of compounds -LRB- I -RRB- and -LRB- II -RRB- were easy obtained in good yield . 17229142 3 10-alanine 535,545 PABPN1 493,499 10-alanine PABPN1 null 8106 Chemical Gene segment|amod|START_ENTITY extension|nmod|segment result|nmod|extension binding_protein_1|acl:relcl|result binding_protein_1|appos|END_ENTITY The disorder is caused by trinucleotide -LRB- GCG -RRB- expansions in the N-terminal part of the poly -LRB- A -RRB- - binding_protein_1 -LRB- PABPN1 -RRB- that result in the extension of a 10-alanine segment by up to seven more alanines . 2426568 1 10-alkyl 137,145 thymidylate_synthase 192,212 10-alkyl thymidylate synthase null 7298 Chemical Gene derivatives|amod|START_ENTITY 10-deazaaminopterin|conj|derivatives 10-deazaaminopterin|conj|polyglutamates polyglutamates|nmod|END_ENTITY The action of 10-deazaaminopterin , its 10-alkyl derivatives , and their polyglutamates against thymidylate_synthase -LRB- TMPS -RRB- from human acute_myeloblastic_leukemia was examined . 1381398 6 1-0-alkyl-2-acetyl_sn-glycero-3-phosphocholine 1379,1425 IL-8 1470,1474 1-0-alkyl-2-acetyl sn-glycero-3-phosphocholine IL-8 null 3576 Chemical Gene agonists|amod|START_ENTITY agonists|acl:relcl|produced produced|nmod|END_ENTITY In contrast , two other neutrophil agonists 1-0-alkyl-2-acetyl_sn-glycero-3-phosphocholine and granulocyte-macrophage-CSF , which , like IL-8 , are produced by activated HUVEC , as well as the leukocyte-derived chemoattractant leukotriene B4 , exerted minimal inhibitory effects on adhesion . 2325013 1 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine 260,306 PAF 255,258 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine PAF null 109585(Tax:10090) Chemical Gene END_ENTITY|dep|START_ENTITY When male mouse spleen cells were incubated with a combination of platelet_activating_factor -LRB- PAF , 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- and sera from female mice in oestrus , the cells displayed a markedly increased rosette inhibition titre -LRB- RIT -RRB- when subsequently tested in the rosette inhibition assay . 3110054 5 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine 1024,1070 PAF 1019,1022 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine PAF null 9768 Chemical Gene END_ENTITY|dep|START_ENTITY In particular , platelet-activating_factor -LRB- PAF ; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- was found to cause rapid , but transient , increases in -LSB- Ca2 + -RSB- i -LRB- from resting levels of about 70 nM to peaks of about 400 nM -RRB- even at concentrations as low as 10 -LRB- -10 -RRB- M . 2325013 1 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine 260,306 platelet_activating_factor 227,253 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine platelet activating factor null 109585(Tax:10090) Chemical Gene PAF|dep|START_ENTITY END_ENTITY|dep|PAF When male mouse spleen cells were incubated with a combination of platelet_activating_factor -LRB- PAF , 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- and sera from female mice in oestrus , the cells displayed a markedly increased rosette inhibition titre -LRB- RIT -RRB- when subsequently tested in the rosette inhibition assay . 3110054 5 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine 1024,1070 platelet-activating_factor 991,1017 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine platelet-activating factor null 9768 Chemical Gene PAF|dep|START_ENTITY END_ENTITY|appos|PAF In particular , platelet-activating_factor -LRB- PAF ; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- was found to cause rapid , but transient , increases in -LSB- Ca2 + -RSB- i -LRB- from resting levels of about 70 nM to peaks of about 400 nM -RRB- even at concentrations as low as 10 -LRB- -10 -RRB- M . 2466463 1 1-0-alkyl-2-acylglycerol 204,228 AAG 198,201 1-0-alkyl-2-acylglycerol AAG null 4350 Chemical Gene 1,2-diacylglycerol|conj|START_ENTITY 1,2-diacylglycerol|appos|END_ENTITY Quantitation of 1,2-diacylglycerol -LRB- AAG -RRB- , 1-0-alkyl-2-acylglycerol -LRB- EAG -RRB- and phosphatidic_acid -LRB- PA -RRB- was conducted in polymorphonuclear leukocytes -LRB- PMN -RRB- labeled with 1-0 - -LSB- 3H -RSB- alkyl-2-acyl-GPC following stimulation with 1 microM fMLP using Coomassie blue staining and densitometry . 2466463 1 1-0-alkyl-2-acylglycerol 204,228 fMLP 388,392 1-0-alkyl-2-acylglycerol fMLP null 2357 Chemical Gene 1,2-diacylglycerol|conj|START_ENTITY Quantitation|nmod|1,2-diacylglycerol conducted|nsubjpass|Quantitation conducted|parataxis|using using|nsubj|stimulation stimulation|nmod|END_ENTITY Quantitation of 1,2-diacylglycerol -LRB- AAG -RRB- , 1-0-alkyl-2-acylglycerol -LRB- EAG -RRB- and phosphatidic_acid -LRB- PA -RRB- was conducted in polymorphonuclear leukocytes -LRB- PMN -RRB- labeled with 1-0 - -LSB- 3H -RSB- alkyl-2-acyl-GPC following stimulation with 1 microM fMLP using Coomassie blue staining and densitometry . 3422154 1 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine 211,255 phospholipase_D 90,105 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine phospholipase D null 2822 Chemical Gene endogenous|amod|START_ENTITY labeled|nmod|endogenous granulocytes|acl|labeled investigated|nmod|granulocytes investigated|nsubjpass|Activation Activation|nmod|END_ENTITY Activation of phospholipase_D -LRB- PLD -RRB- has been investigated in dimethylsulfoxide differentiated HL-60 granulocytes labeled in endogenous 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine -LRB- alkyl-PC -RRB- by incubation with -LSB- 3H -RSB- alkyl-lysoPC . 3422154 1 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine 211,255 PLD 107,110 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine PLD null 2822 Chemical Gene endogenous|amod|START_ENTITY labeled|nmod|endogenous granulocytes|acl|labeled investigated|nmod|granulocytes investigated|nsubjpass|Activation Activation|appos|END_ENTITY Activation of phospholipase_D -LRB- PLD -RRB- has been investigated in dimethylsulfoxide differentiated HL-60 granulocytes labeled in endogenous 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine -LRB- alkyl-PC -RRB- by incubation with -LSB- 3H -RSB- alkyl-lysoPC . 1335527 6 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1365,1413 phospholipase_A2 1417,1433 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine phospholipase A2 MESH:C036761 5319 Chemical Gene START_ENTITY|nmod|END_ENTITY Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity . 1335527 6 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1365,1413 PLA2 1435,1439 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine PLA2 MESH:C036761 5319 Chemical Gene START_ENTITY|nmod|phospholipase_A2 phospholipase_A2|appos|END_ENTITY Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity . 7517616 2 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline 425,470 calcium-dependent_phospholipase_A2 320,354 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline calcium-dependent phospholipase A2 null 5322 Chemical Gene yield|xcomp|START_ENTITY phospholipid|xcomp|yield hydrolyzes|ccomp|phospholipid activated|ccomp|hydrolyzes activated|nsubjpass|END_ENTITY Upon cell stimulation a calcium-dependent_phospholipase_A2 -LRB- PLA2 -RRB- is activated which hydrolyzes a membrane phospholipid to yield 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline -LRB- lyso-PAF -RRB- and free arachidonic_acid . 7517616 2 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline 425,470 PLA2 356,360 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline PLA2 null 5320 Chemical Gene yield|xcomp|START_ENTITY phospholipid|xcomp|yield hydrolyzes|ccomp|phospholipid activated|ccomp|hydrolyzes activated|nsubjpass|calcium-dependent_phospholipase_A2 calcium-dependent_phospholipase_A2|appos|END_ENTITY Upon cell stimulation a calcium-dependent_phospholipase_A2 -LRB- PLA2 -RRB- is activated which hydrolyzes a membrane phospholipid to yield 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline -LRB- lyso-PAF -RRB- and free arachidonic_acid . 6094787 1 10-alkylaminophenothiazines 198,225 calmodulin 143,153 10-alkylaminophenothiazines calmodulin null 801 Chemical Gene quaternary_methiodide_salts|nmod|START_ENTITY prepared|nsubjpass|quaternary_methiodide_salts prepared|advcl|clarify clarify|nmod|the the|nmod|phenothiazines phenothiazines|nmod|END_ENTITY To clarify the role of electrostatic forces in the binding of phenothiazines to calmodulin , the quaternary_methiodide_salts of several 10-alkylaminophenothiazines were prepared and examined for anticalmodulin activity . 1517691 1 1-0-alkyl-glycero-3-phosphocholine 272,306 C5a 202,205 1-0-alkyl-glycero-3-phosphocholine C5a MESH:C029271 362119(Tax:10116) Chemical Gene transferase|amod|START_ENTITY A|dep|transferase A|amod|activation activation|conj|components components|appos|C3a C3a|dep|END_ENTITY The effects of in vitro complement activation and of isolated complement components -LRB- C3a , C5a , C3b -RRB- on the activity of the microsomal enzyme acetyl coenzyme A : 1-0-alkyl-glycero-3-phosphocholine acetyl transferase -LRB- AcTr -RRB- in cultured mesangial cells and on the synthesis of prostaglandin_E2 -LRB- PGE2 -RRB- were assessed . 15995176 6 1-0-alkyl-sn-glycero-3-phosphocholine 1093,1130 PAF-AH 1150,1156 1-0-alkyl-sn-glycero-3-phosphocholine PAF-AH null 7941 Chemical Gene START_ENTITY|nmod|inactivation inactivation|amod|END_ENTITY However , upon LDL oxidation in the presence of exogenous 1-0-alkyl-sn-glycero-3-phosphocholine -LRB- lyso-PAF -RRB- without PAF-AH inactivation , C16 :0 PAF formation accounted for > 90 % of the biological activity recovered . 1335527 6 1-0-alkyl-sn-glyceryl-3-phosphorylcholine 1295,1336 phospholipase_A2 1417,1433 1-0-alkyl-sn-glyceryl-3-phosphorylcholine phospholipase A2 MESH:C029419 5319 Chemical Gene START_ENTITY|acl|generated generated|nmod|activity activity|amod|1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine|nmod|END_ENTITY Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity . 1335527 6 1-0-alkyl-sn-glyceryl-3-phosphorylcholine 1295,1336 PLA2 1435,1439 1-0-alkyl-sn-glyceryl-3-phosphorylcholine PLA2 MESH:C029419 5319 Chemical Gene START_ENTITY|acl|generated generated|nmod|activity activity|amod|1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine|nmod|phospholipase_A2 phospholipase_A2|appos|END_ENTITY Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity . 17940284 1 10-amino_acid 226,239 Atp6p 121,126 10-amino acid Atp6p null 854601(Tax:4932) Chemical Gene presequence|amod|START_ENTITY synthesized|nmod|presequence synthesized|nsubjpass|END_ENTITY Atp6p -LRB- subunit 6 -RRB- of the Saccharomyces_cerevisiae mitochondrial ATPase is synthesized with an N-terminal 10-amino_acid presequence that is cleaved during assembly of the complex . 8497191 10 10-amino_acid 1412,1425 AUA1 1437,1441 10-amino acid AUA1 null 850537(Tax:4932) Chemical Gene segment|amod|START_ENTITY segment|nmod|END_ENTITY Interestingly , a 10-amino_acid segment of AUA1 is directly repeated in the most basic segment of the protein . 8798639 8 10-amino_acid 1381,1394 beta2AR 1403,1410 10-amino acid beta2AR null 154 Chemical Gene region|amod|START_ENTITY region|dep|residues residues|amod|END_ENTITY The results from more selective mutants -LRB- S - -LRB- 149-166 -RRB- , S - -LRB- 164-173 -RRB- , and S - -LRB- 149-158 -RRB- -RRB- indicated that a limited 10-amino_acid region -LRB- beta2AR residues 149-158 -RRB- , localized at the interface of the cytoplasm and the transmembrane domain , contains a critical determinant for exosite binding . 1849641 6 10-amino_acid 1235,1248 beta_2AR 1275,1283 10-amino acid beta 2AR null 154 Chemical Gene segment|amod|START_ENTITY segment|nmod|domain domain|nmod|END_ENTITY We replaced four serine and threonine residues located within a 10-amino_acid segment of this domain of beta_2AR and thereby prevented agonist-promoted phosphorylation , sequestration , and rapid desensitization of the adenylyl cyclase response . 8576242 9 10-amino_acid 1157,1170 Cdc2 1200,1204 10-amino acid Cdc2 null 396252(Tax:9031) Chemical Gene insert|amod|START_ENTITY HMMexp|nmod|insert phosphorylated|nsubjpass|HMMexp phosphorylated|nmod|END_ENTITY HMMexp with the 10-amino_acid insert was phosphorylated by Cdc2 , Cdk5 , and mitogen-activated protein kinase in vitro to 0.3-0 .4 mol of PO4/mol of MHC . 8576242 9 10-amino_acid 1157,1170 Cdk5 1206,1210 10-amino acid Cdk5 null 100190948(Tax:9031) Chemical Gene insert|amod|START_ENTITY HMMexp|nmod|insert phosphorylated|nsubjpass|HMMexp phosphorylated|nmod|Cdc2 Cdc2|conj|END_ENTITY HMMexp with the 10-amino_acid insert was phosphorylated by Cdc2 , Cdk5 , and mitogen-activated protein kinase in vitro to 0.3-0 .4 mol of PO4/mol of MHC . 9226470 3 10-amino_acid 427,440 c-Jun_aminoterminal_kinase 575,601 10-amino acid c-Jun aminoterminal kinase null 26419(Tax:10090) Chemical Gene segment|amod|START_ENTITY rescue|nsubj|segment demonstrated|ccomp|rescue demonstrated|conj|involved involved|nmod|activation activation|nmod|END_ENTITY We demonstrated that a 10-amino_acid segment in the conserved cytoplasmic region of CD40-mediated rescue from IgM-induced cell death and was involved in the activation of c-Jun_aminoterminal_kinase -LRB- JNK -RRB- . 17686645 5 10-amino_acid 782,795 DAX1 675,679 10-amino acid DAX1 MESH:D000596 190 Chemical Gene motif|amod|START_ENTITY replaced|nmod|motif lacks|conj|replaced isoform|acl:relcl|lacks isoform|nmod|END_ENTITY DAX1A is an alternatively spliced isoform of DAX1 that lacks the last 80 amino acids of the DAX1 C-terminal repressor domain and is replaced by a novel 10-amino_acid motif . 17686645 5 10-amino_acid 782,795 DAX1 722,726 10-amino acid DAX1 MESH:D000596 190 Chemical Gene motif|amod|START_ENTITY replaced|nmod|motif lacks|conj|replaced lacks|dobj|acids acids|nmod|domain domain|compound|END_ENTITY DAX1A is an alternatively spliced isoform of DAX1 that lacks the last 80 amino acids of the DAX1 C-terminal repressor domain and is replaced by a novel 10-amino_acid motif . 21266171 5 10-amino_acid 707,720 EAAT3 776,781 10-amino acid EAAT3 MESH:D000596 6505 Chemical Gene peptide|amod|START_ENTITY conjugated|dobj|peptide conjugated|nmod|sequence sequence|amod|identical identical|nmod|that that|nmod|END_ENTITY We conjugated a 10-amino_acid synthetic peptide with a sequence identical to that of EAAT3 around the S465 to a peptide that can facilitate permeation of the plasma membrane . 7720083 7 10-amino_acid 1526,1539 gp120 1591,1596 10-amino acid gp120 MESH:D000596 155971(Tax:11676) Chemical Gene peptide|amod|START_ENTITY peptide|nmod|region region|nmod|HIV-1 HIV-1|nummod|END_ENTITY These results establish that a carrier-free 10-amino_acid synthetic peptide from the V3 loop region in HIV-1 gp120 has the optimal sequence for efficient induction of HIV env-specific CTLs in mice . 8034658 5 10-amino_acid 1000,1013 gp130 978,983 10-amino acid gp130 null 3572 Chemical Gene TQPLLDSEER|amod|START_ENTITY crucial|nsubj|TQPLLDSEER revealed|ccomp|crucial revealed|nsubj|Mutants Mutants|nmod|truncations truncations|nmod|domain domain|nmod|END_ENTITY Mutants with different truncations within the intracellular domain of gp130 revealed that a 10-amino_acid sequence TQPLLDSEER is crucial for efficient internalization . 8621406 2 10-amino_acid 374,387 gp130 443,448 10-amino acid gp130 null 3572 Chemical Gene TQPLLDSEER|amod|START_ENTITY TQPLLDSEER|nmod|domain domain|nmod|END_ENTITY Our previous studies revealed that the 10-amino_acid sequence TQPLLDSEER within the intracellular domain of gp130 is crucial for the efficient internalization of IL-6 . 18310283 2 10-amino_acid 344,357 GRP 377,380 10-amino acid GRP null 225642(Tax:10090) Chemical Gene epitope|amod|START_ENTITY epitope|nmod|fragment fragment|compound|END_ENTITY We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection . 2160654 2 10-amino_acid 470,483 GRP 484,487 10-amino acid GRP null 100728828 Chemical Gene peptide|amod|START_ENTITY peptide|compound|END_ENTITY In extracts of myenteric plexus and gradients derived therefrom , the 10-amino_acid GRP peptide -LRB- GRP-10 -RRB- was the sole form present ; this was bimodally distributed in the gradients , one peak copurifying with Golgi membranes and apparently consisting of immature storage particles , the other with other synaptophysin-rich neuropeptide-containing particles . 12576325 8 10-amino_acid 1265,1278 HLA-A/B 1350,1357 10-amino acid HLA-A/B null 3105;3106 Chemical Gene haplotypes|amod|START_ENTITY haplotypes|amod|peptides peptides|conj|fitting fitting|nmod|END_ENTITY There were 8 - to 10-amino_acid -LRB- aa -RRB- long peptides corresponding to the CDRs and fitting to the actual HLA-A/B haplotypes that spontaneously recognized , albeit with a low magnitude , type I T cells -LRB- interferon gamma -RRB- , indicating an ongoing major histocompatibility complex -LRB- MHC -RRB- class I-restricted T-cell response . 18310283 2 10-amino_acid 344,357 HSP65 287,292 10-amino acid HSP65 null 15510(Tax:10090) Chemical Gene epitope|amod|START_ENTITY copies|nmod|epitope consists|nmod|copies END_ENTITY|acl:relcl|consists We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection . 18310283 2 10-amino_acid 344,357 HSP65 433,438 10-amino acid HSP65 null 15510(Tax:10090) Chemical Gene epitope|amod|START_ENTITY epitope|nmod|fragment fragment|acl|carried carried|nmod|END_ENTITY We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection . 8621406 2 10-amino_acid 374,387 IL-6 497,501 10-amino acid IL-6 null 3569 Chemical Gene TQPLLDSEER|amod|START_ENTITY crucial|nsubj|TQPLLDSEER crucial|nmod|internalization internalization|nmod|END_ENTITY Our previous studies revealed that the 10-amino_acid sequence TQPLLDSEER within the intracellular domain of gp130 is crucial for the efficient internalization of IL-6 . 9226470 3 10-amino_acid 427,440 JNK 603,606 10-amino acid JNK null 26419(Tax:10090) Chemical Gene segment|amod|START_ENTITY rescue|nsubj|segment demonstrated|ccomp|rescue demonstrated|conj|involved involved|nmod|activation activation|nmod|c-Jun_aminoterminal_kinase c-Jun_aminoterminal_kinase|appos|END_ENTITY We demonstrated that a 10-amino_acid segment in the conserved cytoplasmic region of CD40-mediated rescue from IgM-induced cell death and was involved in the activation of c-Jun_aminoterminal_kinase -LRB- JNK -RRB- . 8464900 5 10-amino_acid 861,874 MHC-B 813,818 10-amino acid MHC-B null 397760(Tax:8355) Chemical Gene insert|amod|START_ENTITY contain|dobj|insert contain|nsubj|fraction fraction|nmod|mRNA mRNA|acl|encoding encoding|dobj|isoform isoform|amod|END_ENTITY In chickens and humans , a fraction of the mRNA encoding the MHC-B isoform was found previously to contain a 10-amino_acid insert at amino_acid 211 near the ATP-binding site . 11000493 6 10-amino_acid 959,972 NCAM 1013,1017 10-amino acid NCAM null 4684 Chemical Gene peptide|amod|START_ENTITY Using|dobj|peptide Using|nmod|domain domain|nmod|END_ENTITY Using a 10-amino_acid peptide from the third Ig domain of the NCAM , a peptide fragment within the region recognized by the NCAM antibody , mimics the effect of the molecule in reducing NO production . 11000493 6 10-amino_acid 959,972 NCAM 1074,1078 10-amino acid NCAM null 4684 Chemical Gene peptide|amod|START_ENTITY Using|dobj|peptide fragment|dep|Using fragment|nmod|region region|acl|recognized recognized|nmod|antibody antibody|compound|END_ENTITY Using a 10-amino_acid peptide from the third Ig domain of the NCAM , a peptide fragment within the region recognized by the NCAM antibody , mimics the effect of the molecule in reducing NO production . 9099756 4 10-amino_acid 748,761 OEP34 663,668 10-amino acid OEP34 null 830382(Tax:3702) Chemical Gene core|amod|START_ENTITY located|nmod|core show|ccomp|located show|advcl|Using Using|dobj|homologue homologue|nmod|END_ENTITY Using an Arabidopsis homologue of the originally isolated pea OEP34 , we show that the outer membrane-targeting signal of OEP34 is located within a 10-amino_acid hydrophobic core of the C-terminal membrane anchor . 9099756 4 10-amino_acid 748,761 OEP34 722,727 10-amino acid OEP34 null 830382(Tax:3702) Chemical Gene core|amod|START_ENTITY located|nmod|core located|nsubjpass|signal signal|nmod|END_ENTITY Using an Arabidopsis homologue of the originally isolated pea OEP34 , we show that the outer membrane-targeting signal of OEP34 is located within a 10-amino_acid hydrophobic core of the C-terminal membrane anchor . 18372524 2 10-amino_acid 186,199 ST3 270,273 10-amino acid ST3 null 4320 Chemical Gene sandwiched|amod|START_ENTITY sandwiched|nmod|pro-domain pro-domain|conj|domain domain|nmod|END_ENTITY In particular , an unusual 10-amino_acid residue sandwiched between the pro-domain and the catalytic domain of ST3 exists in ST3 but not in other matrix metalloproteinases -LRB- MMPs -RRB- . 18372524 2 10-amino_acid 186,199 ST3 284,287 10-amino acid ST3 null 4320 Chemical Gene sandwiched|amod|START_ENTITY exists|nsubj|sandwiched exists|nmod|END_ENTITY In particular , an unusual 10-amino_acid residue sandwiched between the pro-domain and the catalytic domain of ST3 exists in ST3 but not in other matrix metalloproteinases -LRB- MMPs -RRB- . 10670454 2 10-amino-acid 393,406 ADAR2 272,277 10-amino-acid ADAR2 null 104 Chemical Gene insert|amod|START_ENTITY presence|nmod|insert differ|nmod|presence variants|acl:relcl|differ giving|nmod|variants undergoes|advcl|giving undergoes|nsubj|END_ENTITY In rodents , ADAR2 undergoes alternative RNA splicing , giving rise to two splice variants that differ by the presence or absence of a 10-amino-acid insert in the carboxy-terminal catalytic domain . 1488105 1 10-amino-acid 109,122 bombesin 148,156 10-amino-acid bombesin null 2922 Chemical Gene peptide|amod|START_ENTITY peptide|nmod|family family|compound|END_ENTITY Neuromedin_B is a 10-amino-acid mammalian peptide of the bombesin family . 9032281 7 10-amino-acid 828,841 CD30 884,888 10-amino-acid CD30 null 943 Chemical Gene elements|amod|START_ENTITY elements|acl:relcl|mediate mediate|dobj|family family|amod|binding binding|nmod|END_ENTITY Domain 2 contains two 5 - to 10-amino-acid elements which can mediate the binding of CD30 to members of the tumor necrosis factor receptor-associated factor -LRB- TRAF -RRB- family of signal transducing proteins . 9144420 0 10-amino-acid 24,37 CD40 75,79 10-amino-acid CD40 null 958 Chemical Gene segment|amod|START_ENTITY segment|nmod|region region|nmod|MAP MAP|amod|END_ENTITY Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses . 18523634 5 10-amino-acid 955,968 CD8 1003,1006 10-amino-acid CD8 null 925 Chemical Gene SALKLAIYKA|amod|START_ENTITY SALKLAIYKA|dep|% %|nmod|cells cells|compound|END_ENTITY Using pools of overlapping peptides spanning the whole B19V proteome , strong CD8 -LRB- + -RRB- T-cell responses were elicited to the 10-amino-acid peptides SALKLAIYKA -LRB- 19.7 % of all CD8 -LRB- + -RRB- cells -RRB- and QSALKLAIYK -LRB- 10 % -RRB- and additional weaker responses to GLCPHCINVG -LRB- 0.71 % -RRB- and LLHTDFEQVM -LRB- 0.06 % -RRB- . 18523634 5 10-amino-acid 955,968 CD8 910,913 10-amino-acid CD8 null 925 Chemical Gene SALKLAIYKA|amod|START_ENTITY elicited|nmod|SALKLAIYKA T-cell|ccomp|elicited T-cell|nsubj|END_ENTITY Using pools of overlapping peptides spanning the whole B19V proteome , strong CD8 -LRB- + -RRB- T-cell responses were elicited to the 10-amino-acid peptides SALKLAIYKA -LRB- 19.7 % of all CD8 -LRB- + -RRB- cells -RRB- and QSALKLAIYK -LRB- 10 % -RRB- and additional weaker responses to GLCPHCINVG -LRB- 0.71 % -RRB- and LLHTDFEQVM -LRB- 0.06 % -RRB- . 2143919 2 10-amino-acid 262,275 CD8 227,230 10-amino-acid CD8 null 925 Chemical Gene bearing|dep|START_ENTITY bearing|dobj|END_ENTITY CTLs bearing the surface molecule CD8 recognize small -LRB- approximately 10-amino-acid -RRB- viral peptides that are presented in association with major histocompatibility -LRB- MHC -RRB- class I molecules at the surface of tumor cells . 7908700 6 10-amino-acid 1241,1254 CD8 1182,1185 10-amino-acid CD8 null 925 Chemical Gene epitope|amod|START_ENTITY restricted|dobj|epitope HLA-A3|acl|restricted HLA-A3|nsubj|response response|compound|END_ENTITY An immunodominant CD8 + CTL response was HLA-A3 .1 restricted and recognized a 10-amino-acid epitope -LRB- gp120/38 -47 -RRB- in a highly conserved region of gp120 . 20641585 14 10-amino-acid 2632,2645 CH1 2516,2519 10-amino-acid CH1 null 51430 Chemical Gene spacer|amod|START_ENTITY addition|nmod|spacer followed|nmod|addition domain|acl|followed domain|compound|END_ENTITY The light chain constant domain was a human Ck , and the human y1 chain was genetically modified to produce a heavy chain composed of a CH1 domain followed by a partial IgG1 hinge region tethered to the CH3 heavy chain domain by addition of a flexible 10-amino-acid GGGSSGGGSG spacer -LRB- 22 -RRB- . 25341359 2 10-amino-acid 374,387 c-Met 448,453 10-amino-acid c-Met null 4233 Chemical Gene spacer|amod|START_ENTITY separated|nmod|spacer residues|acl|separated located|nsubj|residues located|nmod|region region|nmod|function function|amod|END_ENTITY Here , we report that two histidine residues separated by a 10-amino-acid spacer -LRB- H1068-H1079 -RRB- located in the juxtamembrane region of c-Met function as a putative novel NLS . 11683359 10 10-amino-acid 1036,1049 cysteine-rich_secretory_protein-1 1095,1128 10-amino-acid cysteine-rich secretory protein-1 null 167 Chemical Gene sequence|amod|START_ENTITY showed|nsubj|sequence showed|dobj|similarity similarity|nmod|precursor precursor|amod|END_ENTITY The first 10-amino-acid sequence showed 60-77 % similarity with human cysteine-rich_secretory_protein-1 precursor , inhibin alpha chain precursor . 7746327 4 10-amino-acid 791,804 furin 982,987 10-amino-acid furin null 5045 Chemical Gene insert|amod|START_ENTITY insert|acl:relcl|encrypted encrypted|nmod|motif motif|nmod|proteinase proteinase|appos|END_ENTITY Intracellular activation is regulated by an unusual 10-amino-acid insert sandwiched between the pro- and catalytic-domains of stromelysin-3 , which is encrypted with an Arg-X-Arg-X-Lys-Arg recognition motif for the Golgi-associated proteinase , furin , a mammalian homologue of the yeast Kex2 pheromone convertase . 23159559 4 10-amino-acid 551,564 GLD-3 579,584 10-amino-acid GLD-3 null 174174(Tax:6239) Chemical Gene region|amod|START_ENTITY region|nmod|END_ENTITY A 10-amino-acid region within GLD-3 is required for FBF binding , while a 7-amino-acid loop in FBF between PUF repeats 7 and 8 is necessary for GLD-3 binding . 23159559 4 10-amino-acid 551,564 GLD-3 692,697 10-amino-acid GLD-3 null 174174(Tax:6239) Chemical Gene region|amod|START_ENTITY required|nsubjpass|region required|advcl|repeats repeats|ccomp|necessary necessary|nmod|END_ENTITY A 10-amino-acid region within GLD-3 is required for FBF binding , while a 7-amino-acid loop in FBF between PUF repeats 7 and 8 is necessary for GLD-3 binding . 12447356 1 10-amino-acid 283,296 GnRH-II 264,271 10-amino-acid GnRH-II null 2797 Chemical Gene neuropeptide|amod|START_ENTITY gonadotropin-releasing_hormone-II|appos|neuropeptide gonadotropin-releasing_hormone-II|appos|END_ENTITY Can T cells be directly activated to de novo gene expression by gonadotropin-releasing_hormone-II -LRB- GnRH-II -RRB- , a unique 10-amino-acid neuropeptide conserved through 500 million years of evolution ? 12447356 1 10-amino-acid 283,296 gonadotropin-releasing_hormone-II 229,262 10-amino-acid gonadotropin-releasing hormone-II null 2797 Chemical Gene neuropeptide|amod|START_ENTITY END_ENTITY|appos|neuropeptide Can T cells be directly activated to de novo gene expression by gonadotropin-releasing_hormone-II -LRB- GnRH-II -RRB- , a unique 10-amino-acid neuropeptide conserved through 500 million years of evolution ? 7908700 6 10-amino-acid 1241,1254 gp120 1309,1314 10-amino-acid gp120 null 3700 Chemical Gene epitope|amod|START_ENTITY restricted|dobj|epitope restricted|nmod|region region|nmod|END_ENTITY An immunodominant CD8 + CTL response was HLA-A3 .1 restricted and recognized a 10-amino-acid epitope -LRB- gp120/38 -47 -RRB- in a highly conserved region of gp120 . 1501277 2 10-amino-acid 510,523 HBc 476,479 10-amino-acid HBc null 85348 Chemical Gene portion|amod|START_ENTITY due|nmod|portion due|nsubj|properties properties|acl:relcl|distinguish distinguish|nmod|protein protein|compound|END_ENTITY The data show that the properties which distinguish the HBe protein from the HBc protein are due mostly to the 10-amino-acid portion of the HBe leader sequence which remains attached to the HBe protein after cleavage . 12359743 6 10-amino-acid 939,952 KiSS1 858,863 10-amino-acid KiSS1 null 280287(Tax:10090) Chemical Gene residues|amod|START_ENTITY peptides|appos|residues conserved|nsubj|peptides conserved|advcl|share share|nsubj|proteins proteins|compound|END_ENTITY Although human and mouse KiSS1 proteins share relatively low overall homology -LRB- 52 % -RRB- , the active peptides -LRB- 10-amino-acid residues -RRB- are highly conserved between mouse and human KiSS1 proteins , varying by only one conserved amino_acid -LSB- Tyr -LRB- Y -RRB- to Phe -LRB- F -RRB- -RSB- . 2722848 5 10-amino-acid 872,885 LDL_receptor 751,763 10-amino-acid LDL receptor null 3949 Chemical Gene linker|amod|START_ENTITY directed|nmod|linker shows|conj|directed shows|nsubj|END_ENTITY Under these conditions , the human LDL_receptor shows high affinity for 125I-LDL and for 125I-IgG-HL1 , a monoclonal antipeptide antibody directed against a 10-amino-acid `` linker '' between repeats 4 and 5 in the ligand binding domain . 10873763 3 10-amino-acid 565,578 LMP1 537,541 10-amino-acid LMP1 MESH:D000596 9260 Chemical Gene deletion|amod|START_ENTITY variants|nmod|deletion variants|nummod|END_ENTITY The identification of LMP1 variants with a common 10-amino-acid deletion and additional point mutations -LRB- typified by the CAO-LMP1 isolate -RRB- in EBV strains associated with nasopharyngeal_carcinoma prompted us to examine the effect of stable prototype B95.8-LMP1 and CAO-LMP1 expression on the phenotype and differentiation of SCC12F human epithelial cells . 9557692 1 10-amino-acid 258,271 LMP1 349,353 10-amino-acid LMP1 null 17494204 Chemical Gene deletion|amod|START_ENTITY characterized|nmod|deletion characterized|nmod|domain domain|nmod|protein protein|appos|END_ENTITY One group of sequence variants of Epstein-Barr_virus is characterized by a 10-amino-acid deletion within the CTAR-2 functional domain of the latent membrane protein , LMP1 . 9407003 4 10-amino-acid 615,628 LMP_1 686,691 10-amino-acid LMP 1 null 9260 Chemical Gene deletion|amod|START_ENTITY affected|nsubj|deletion affected|nmod|END_ENTITY In this study , we tested if this 10-amino-acid deletion affected the induction of NF-kappaB activity by LMP_1 . 9858609 7 10-amino-acid 1420,1433 mdm2 1598,1602 10-amino-acid mdm2 MESH:D000596 314856(Tax:10116) Chemical Gene sequence|amod|START_ENTITY important|nsubj|sequence important|nmod|activation activation|nmod|element element|amod|END_ENTITY A 10-amino-acid sequence in the N-terminal region of T3Ralpha that is important for transactivation and interaction with TFIIB was also found to be important for activation of the mdm2 gene response element . 10627389 6 10-amino-acid 862,875 MIP-1_beta 888,898 10-amino-acid MIP-1 beta null 395551(Tax:9031) Chemical Gene peptides|amod|START_ENTITY peptides|nmod|END_ENTITY The chemotactic activity could be neutralized by antibodies prepared against two 10-amino-acid peptides of MIP-1_beta , indicating that the substance was MIP-1_beta . 10627389 6 10-amino-acid 862,875 MIP-1_beta 934,944 10-amino-acid MIP-1 beta null 395551(Tax:9031) Chemical Gene peptides|amod|START_ENTITY prepared|nmod|peptides prepared|xcomp|indicating indicating|ccomp|END_ENTITY The chemotactic activity could be neutralized by antibodies prepared against two 10-amino-acid peptides of MIP-1_beta , indicating that the substance was MIP-1_beta . 11082039 10 10-amino-acid 1550,1563 MRP1 1671,1675 10-amino-acid MRP1 null 4363 Chemical Gene deletion|amod|START_ENTITY abolished|nsubj|deletion abolished|nmod|function function|compound|END_ENTITY A 10-amino-acid deletion in a predicted amphipathic region of L -LRB- 0 -RRB- abolished its attachment to the membrane and eliminated MRP1 transport function , but did not affect membrane routing . 1488105 1 10-amino-acid 109,122 Neuromedin_B 91,103 10-amino-acid Neuromedin B null 4828 Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY Neuromedin_B is a 10-amino-acid mammalian peptide of the bombesin family . 9817857 1 10-amino-acid 267,280 OspC 293,297 10-amino-acid OspC null 13917590 Chemical Gene residues|amod|START_ENTITY residues|nmod|END_ENTITY Sera from 210 patients with Lyme_borreliosis -LRB- LB -RRB- were studied by an enzyme-linked immunosorbent assay -LRB- ELISA -RRB- based on a synthetic peptide -LRB- pepC10 -RRB- comprising the C-terminal 10-amino-acid residues of OspC of Borrelia_burgdorferi . 1448076 6 10-amino-acid 912,925 p59fyn 889,895 10-amino-acid p59fyn null 2534 Chemical Gene sequence|amod|START_ENTITY responsible|nsubj|sequence revealed|ccomp|responsible revealed|nsubj|analysis analysis|nmod|END_ENTITY Mutational analysis of p59fyn revealed that a 10-amino-acid sequence in the unique amino-terminal domain of p59fyn was responsible for the association with zeta . 1448076 6 10-amino-acid 912,925 p59fyn 974,980 10-amino-acid p59fyn null 2534 Chemical Gene sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY Mutational analysis of p59fyn revealed that a 10-amino-acid sequence in the unique amino-terminal domain of p59fyn was responsible for the association with zeta . 8635515 6 10-amino-acid 634,647 RAR_alpha 613,622 10-amino-acid RAR alpha null 19401(Tax:10090) Chemical Gene insert|amod|START_ENTITY carrying|dobj|insert END_ENTITY|acl|carrying A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain . 8635515 6 10-amino-acid 634,647 RAR_alpha 714,723 10-amino-acid RAR alpha null 19401(Tax:10090) Chemical Gene insert|amod|START_ENTITY carrying|dobj|insert RAR_alpha|acl|carrying mutant|nmod|RAR_alpha heterodimerize|nsubj|mutant heterodimerize|nmod|RXRbeta RXRbeta|conj|END_ENTITY A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain . 8635515 6 10-amino-acid 634,647 RXRbeta 687,694 10-amino-acid RXRbeta null 20182(Tax:10090) Chemical Gene insert|amod|START_ENTITY carrying|dobj|insert RAR_alpha|acl|carrying mutant|nmod|RAR_alpha heterodimerize|nsubj|mutant heterodimerize|nmod|END_ENTITY A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain . 12231168 3 10-amino-acid 707,720 SERPINA1 672,680 10-amino-acid SERPINA1 null 5265 Chemical Gene tag|dep|START_ENTITY tagged|nmod|tag gene|acl|tagged gene|compound|END_ENTITY Subsequent studies made use of the baboon SERPINA1 gene tagged with a short -LRB- 10-amino-acid -RRB- c-myc tag . 9271397 7 10-amino-acid 1464,1477 Sp1 1513,1516 10-amino-acid Sp1 null 31913(Tax:7227) Chemical Gene stretch|amod|START_ENTITY stretch|acl:relcl|present present|nmod|members members|amod|END_ENTITY This crucial domain encompasses the buttonhead box , which is a 10-amino-acid stretch that is present in several Sp1 family members , including the Drosophila buttonhead gene product . 7746327 4 10-amino-acid 791,804 stromelysin-3 865,878 10-amino-acid stromelysin-3 null 4320 Chemical Gene insert|amod|START_ENTITY insert|nmod|pro- pro-|nmod|END_ENTITY Intracellular activation is regulated by an unusual 10-amino-acid insert sandwiched between the pro- and catalytic-domains of stromelysin-3 , which is encrypted with an Arg-X-Arg-X-Lys-Arg recognition motif for the Golgi-associated proteinase , furin , a mammalian homologue of the yeast Kex2 pheromone convertase . 7623841 0 10-amino-acid 2,15 thyroid_hormone_receptor_alpha 57,87 10-amino-acid thyroid hormone receptor alpha null 396251(Tax:9031) Chemical Gene sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY A 10-amino-acid sequence in the N-terminal A/B domain of thyroid_hormone_receptor_alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB . 21507971 4 10-amino-acid 832,845 Vpx 759,762 10-amino-acid Vpx null 1490006(Tax:11723) Chemical Gene motif|amod|START_ENTITY localized|nmod|motif localized|dobj|motif motif|compound|END_ENTITY We localized the minimal Vpx packaging motif of simian_immunodeficiency_virus SIVmac -LRB- 239 -RRB- p6 to a 10-amino-acid motif and introduced this sequence into an infectious_HIV-1 provirus . 21651901 1 10-amino_acid_peptide 142,163 PTD 314,317 10-amino acid peptide PTD null 617 Chemical Gene derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|nmod|domain domain|appos|END_ENTITY Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- . 21440624 2 10-amino_acid_peptide 328,349 TCTP 446,450 10-amino acid peptide TCTP null 7178 Chemical Gene derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|appos|END_ENTITY We previously reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a PTD . 21651901 1 10-amino_acid_peptide 142,163 TCTP 264,268 10-amino acid peptide TCTP null 7178 Chemical Gene derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|appos|END_ENTITY Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- . 21440624 2 10-amino_acid_peptide 328,349 translationally_controlled_tumor_protein 404,444 10-amino acid peptide translationally controlled tumor protein null 7178 Chemical Gene derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|compound|END_ENTITY We previously reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a PTD . 21651901 1 10-amino_acid_peptide 142,163 translationally_controlled_tumor_protein 222,262 10-amino acid peptide translationally controlled tumor protein null 7178 Chemical Gene derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|compound|END_ENTITY Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- . 10482456 3 10-aminobenzoindolizidines 476,502 acetylcholinesterase 396,416 10-aminobenzoindolizidines acetylcholinesterase null 43 Chemical Gene 11-aminobenzoquinolizidines|conj|START_ENTITY employing|xcomp|11-aminobenzoquinolizidines produce|advcl|employing produce|dobj|inhibitor inhibitor|amod|END_ENTITY The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines -LRB- 4 -RRB- and 10-aminobenzoindolizidines -LRB- 5 -RRB- as templates . 16001167 11 10-amino-CPT 1398,1410 BCRP 1731,1735 10-amino-CPT BCRP MESH:C106646 9429 Chemical Gene uptake|nmod|START_ENTITY cells|appos|uptake increased|nsubj|cells indicated|parataxis|increased indicated|ccomp|changed changed|nmod|down-regulation down-regulation|nmod|breast_cancer_resistance_protein breast_cancer_resistance_protein|appos|END_ENTITY In MCF-7 / wt cells , uptake of 10-amino-CPT increased 4-fold , while retention increased over 10-fold at acidic extracellular pH. In addition , gene expression analysis of MCF-7 / wt cells indicated that expression of a number of genes changed under acidic culture conditions , including down-regulation of the CPT efflux protein pump breast_cancer_resistance_protein -LRB- BCRP -RRB- . 16001167 11 10-amino-CPT 1398,1410 breast_cancer_resistance_protein 1697,1729 10-amino-CPT breast cancer resistance protein MESH:C106646 9429 Chemical Gene uptake|nmod|START_ENTITY cells|appos|uptake increased|nsubj|cells indicated|parataxis|increased indicated|ccomp|changed changed|nmod|down-regulation down-regulation|nmod|END_ENTITY In MCF-7 / wt cells , uptake of 10-amino-CPT increased 4-fold , while retention increased over 10-fold at acidic extracellular pH. In addition , gene expression analysis of MCF-7 / wt cells indicated that expression of a number of genes changed under acidic culture conditions , including down-regulation of the CPT efflux protein pump breast_cancer_resistance_protein -LRB- BCRP -RRB- . 16272718 3 10-amino-goniothalamin 454,476 vp-16 636,641 10-amino-goniothalamin vp-16 null 3054 Chemical Gene 10-nitro-goniothalamin|conj|START_ENTITY derivatives|amod|10-nitro-goniothalamin gave|nsubj|derivatives gave|advcl|microg/ml microg/ml|nsubj|that that|nmod|etoposide etoposide|dep|END_ENTITY The derivatives 10-nitro-goniothalamin and 10-amino-goniothalamin gave selective inhibition concentration -LRB- IC50 -RRB- of 1.10 and 1.14 microg/ml , respectively , against human stomach_cancer SGC-7901 cells , while that of etoposide -LRB- vp-16 -RRB- as the positive control was 6.07 microg/ml . 15998636 5 10_Arg-Gly-Gly 872,886 Npl3 838,842 10 Arg-Gly-Gly Npl3 null 852042(Tax:4932) Chemical Gene tripeptides|amod|START_ENTITY dimethylated|nsubjpass|tripeptides purified|advcl|dimethylated END_ENTITY|acl|purified Matrix-assisted laser desorption/ionization Fourier transform mass spectrometry was used to identify 17 methylated arginines in Npl3 purified from yeast : whereas 10_Arg-Gly-Gly -LRB- RGG -RRB- tripeptides were exclusively dimethylated , variable levels of methylation were found for 5 RGG and 2 RG motif arginines . 8691487 0 10-arylisoalloxazines 45,66 glutathione_reductase 20,41 10-arylisoalloxazines glutathione reductase null 2936 Chemical Gene END_ENTITY|nmod|START_ENTITY Inhibition of human glutathione_reductase by 10-arylisoalloxazines : crystalline , kinetic , and electrochemical studies . 14729370 1 10-azaBaP 158,167 BaP 189,192 10-azaBaP BaP null 11331 Chemical Gene pyrene|dep|START_ENTITY -LSB-|dep|pyrene -LSB-|appos|10-aza-analog 10-aza-analog|nmod|END_ENTITY We previously reported that 10-azabenzo -LSB- a -RSB- pyrene -LRB- 10-azaBaP -RRB- , a 10-aza-analog of BaP and an environmental carcinogen , showed greater mutagenicity than BaP in the Ames test using pooled human liver S9 . 14729370 1 10-azaBaP 158,167 BaP 259,262 10-azaBaP BaP null 11331 Chemical Gene pyrene|dep|START_ENTITY -LSB-|dep|pyrene showed|nsubj|-LSB- showed|nmod|END_ENTITY We previously reported that 10-azabenzo -LSB- a -RSB- pyrene -LRB- 10-azaBaP -RRB- , a 10-aza-analog of BaP and an environmental carcinogen , showed greater mutagenicity than BaP in the Ames test using pooled human liver S9 . 14729370 5 10-azaBaP 1029,1038 CYP1A1 1076,1082 10-azaBaP CYP1A1 null 1543 Chemical Gene mutagenicity|nmod|START_ENTITY contributed|nmod|mutagenicity contributed|nmod|END_ENTITY Moreover , recombinant human CYP1A2 contributed to the mutagenicity of 10-azaBaP more markedly than recombinant human CYP1A1 . 14729370 5 10-azaBaP 1029,1038 CYP1A2 987,993 10-azaBaP CYP1A2 null 1544 Chemical Gene mutagenicity|nmod|START_ENTITY contributed|nmod|mutagenicity contributed|nsubj|END_ENTITY Moreover , recombinant human CYP1A2 contributed to the mutagenicity of 10-azaBaP more markedly than recombinant human CYP1A1 . 14729370 6 10-azaBaP 1190,1199 CYP1A2 1111,1117 10-azaBaP CYP1A2 null 1544 Chemical Gene activation|nmod|START_ENTITY responsible|nmod|activation enzyme|amod|responsible enzyme|nsubj|END_ENTITY These results suggest that CYP1A2 may be the principal enzyme responsible for the metabolic activation of 10-azaBaP in human liver microsomes . 6384085 7 10-aza-glycine 1083,1097 LH-RH 1099,1104 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene -RSB-|amod|START_ENTITY END_ENTITY|nsubj|-RSB- The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 7 10-aza-glycine 1083,1097 LH-RH 1175,1180 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene -RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|ccomp|40 40|nsubj|END_ENTITY The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 7 10-aza-glycine 1083,1097 LH-RH 1210,1215 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene -RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|ccomp|40 40|nmod|END_ENTITY The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 7 10-aza-glycine 1159,1173 LH-RH 1099,1104 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene LH-RH|amod|START_ENTITY 40|nsubj|LH-RH END_ENTITY|ccomp|40 The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 7 10-aza-glycine 1159,1173 LH-RH 1175,1180 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene END_ENTITY|amod|START_ENTITY The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 7 10-aza-glycine 1159,1173 LH-RH 1210,1215 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene LH-RH|amod|START_ENTITY 40|nsubj|LH-RH 40|nmod|END_ENTITY The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively . 6384085 8 10-aza-glycine 1304,1318 LH-RH 1320,1325 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene -RSB-|amod|START_ENTITY END_ENTITY|nsubj|-RSB- The most active compound in this series is -LSB- 6 - -LRB- 3 - -LRB- 2-naphthyl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH with a potency 230 times that of LH-RH . 6384085 8 10-aza-glycine 1304,1318 LH-RH 1359,1364 10-aza-glycine LH-RH null 25194(Tax:10116) Chemical Gene -RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|dobj|that that|nmod|END_ENTITY The most active compound in this series is -LSB- 6 - -LRB- 3 - -LRB- 2-naphthyl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH with a potency 230 times that of LH-RH . 22239252 4 10-azidodecanoic_acid 707,728 LAP 732,735 10-azidodecanoic acid LAP null 7939 Chemical Gene START_ENTITY|advcl|END_ENTITY First , we found that the W37I mutant of LplA catalyzes site-specific ligation of 10-azidodecanoic_acid to LAP in cells , in nearly quantitative yield after 30 min . 2879826 2 10_BA 308,313 C-2 340,343 10 BA C-2 null 24231(Tax:10116) Chemical Gene derivatives|nummod|START_ENTITY supported|nmod|derivatives supported|advmod|efficiently efficiently|nmod:npmod|compounds compounds|dep|END_ENTITY Of the 10_BA derivatives , 7 compounds -LRB- C-2 , 3 , 4 , 5 , 6 , 9 , and 10 -RRB- efficiently supported hepatocyte survival for at least 2 wks in primary culture . 9877098 7 10B-BPA 1462,1469 TA1059 1423,1429 10B-BPA TA1059 null 1456575(Tax:273075) Chemical Gene BNCT|nummod|START_ENTITY as|nmod:npmod|BNCT suppressed|advcl|as suppressed|nsubjpass|growth growth|nmod|END_ENTITY In animal experiments , by using these cell lines , tumor growth of TA1059 was significantly suppressed by 10B-BPA BNCT as compared with A1059 . 23939374 7 10-benzylidene-10H-anthracen-9-one 1190,1224 androgen_receptor 1350,1367 10-benzylidene-10H-anthracen-9-one androgen receptor null 367 Chemical Gene analogues|amod|START_ENTITY identified|nmod|analogues identified|ccomp|showed showed|conj|inhibited inhibited|dobj|activity activity|amod|END_ENTITY Of these 10-benzylidene-10H-anthracen-9-one analogues , a lead compound -LRB- VPC-3033 -RRB- was identified that showed strong androgen displacement potency , effectively inhibited androgen_receptor transcriptional activity , and possesses a profound ability to cause degradation of androgen_receptor . 23939374 7 10-benzylidene-10H-anthracen-9-one 1190,1224 androgen_receptor 1451,1468 10-benzylidene-10H-anthracen-9-one androgen receptor null 367 Chemical Gene analogues|amod|START_ENTITY identified|nmod|analogues identified|ccomp|showed showed|conj|possesses possesses|dobj|ability ability|acl|cause cause|dobj|degradation degradation|nmod|END_ENTITY Of these 10-benzylidene-10H-anthracen-9-one analogues , a lead compound -LRB- VPC-3033 -RRB- was identified that showed strong androgen displacement potency , effectively inhibited androgen_receptor transcriptional activity , and possesses a profound ability to cause degradation of androgen_receptor . 23939374 6 10-benzylidene-10H-anthracen-9-ones 997,1032 androgen_receptor 1067,1084 10-benzylidene-10H-anthracen-9-ones androgen receptor null 367 Chemical Gene number|nmod|START_ENTITY number|acl:relcl|inhibit inhibit|dobj|activity activity|amod|END_ENTITY In this study , we implemented and used the synergetic combination of virtual and experimental screening to discover a number of new 10-benzylidene-10H-anthracen-9-ones that not only effectively inhibit androgen_receptor transcriptional activity , but also induce almost complete degradation of the androgen_receptor . 23939374 6 10-benzylidene-10H-anthracen-9-ones 997,1032 androgen_receptor 1162,1179 10-benzylidene-10H-anthracen-9-ones androgen receptor null 367 Chemical Gene number|nmod|START_ENTITY discover|dobj|number discover|conj|induce induce|dobj|degradation degradation|nmod|END_ENTITY In this study , we implemented and used the synergetic combination of virtual and experimental screening to discover a number of new 10-benzylidene-10H-anthracen-9-ones that not only effectively inhibit androgen_receptor transcriptional activity , but also induce almost complete degradation of the androgen_receptor . 1123034 3 10-beta-cyanoethyl 430,448 VIII 455,459 10-beta-cyanoethyl VIII null 1351 Chemical Gene START_ENTITY|dep|VII VII|dep|END_ENTITY 10-Acyl -LRB- III - VI -RRB- and 10-beta-cyanoethyl -LRB- VII , VIII -RRB- derivatives of compounds -LRB- I -RRB- and -LRB- II -RRB- were easy obtained in good yield . 25175223 2 10Br-b-CD 503,512 b-CD 456,460 10Br-b-CD b-CD null 285440 Chemical Gene using|dobj|START_ENTITY introduced|xcomp|using introduced|nmod|surface surface|nmod|END_ENTITY In order to reduce the cytotoxicity of the CD-PAM-b-PMeDMA , biocompatible polyacrylamide -LRB- PAM -RRB- was first introduced onto the surface of b-CD as a scaffold structure by ATRP using the 10Br-b-CD as a macroinitiator . 3088340 1 10-Butyryl 102,112 lipoxygenase-1 178,192 10-Butyryl lipoxygenase-1 null 547923(Tax:3847) Chemical Gene 1,8-dihydroxyanthrone|amod|START_ENTITY inhibited|nsubj|1,8-dihydroxyanthrone inhibited|dobj|soybean soybean|amod|END_ENTITY 10-Butyryl substituted 1,8-dihydroxyanthrone -LRB- butantrone -RRB- inhibited soybean lipoxygenase-1 irreversibly and more efficiently than its parent compound 1,8-dihydroxyanthrone -LRB- dithranol , anthralin -RRB- -LRB- IC50 values 0.090 mM and 1.1 mM , respectively -RRB- . 2209005 1 10-butyryl_dithranol 170,190 MEST 327,331 10-butyryl dithranol MEST MESH:C038464 17294(Tax:10090) Chemical Gene activity|dep|START_ENTITY studied|nsubjpass|activity studied|nmod|models models|dep|test test|conj|mouse_ear_swelling_test mouse_ear_swelling_test|appos|END_ENTITY The contact sensitizing activity of dithranol and butantrone -LRB- 10-butyryl_dithranol -RRB- was studied in 3 animal models : the guinea_pig maximization test -LRB- GPMT -RRB- , the closed patch test -LRB- CPT -RRB- , and the mouse_ear_swelling_test -LRB- MEST -RRB- in 2 different mouse strains . 12151103 3 10_C2H2 456,463 ZNF333 432,438 10 C2H2 ZNF333 null 84449 Chemical Gene motifs|nummod|START_ENTITY contains|dobj|motifs contains|nsubj|END_ENTITY ZNF333 further contains 10_C2H2 zinc finger motifs at the C-terminus . 20724647 2 10-carbon_dicarboxylic_acid 287,314 C10 316,319 10-carbon dicarboxylic acid C10 null 3226 Chemical Gene START_ENTITY|dep|END_ENTITY We aimed to evaluate the effect of sebacic_acid -LRB- a 10-carbon_dicarboxylic_acid ; C10 -RRB- ingestion on postprandial glycemia and glucose rate of appearance -LRB- Ra -RRB- in healthy and type 2 diabetic subjects . 22039047 0 10-carbon_fatty_acid 32,52 peroxisome_proliferator-activated_receptors 77,120 10-carbon fatty acid peroxisome proliferator-activated receptors MESH:D002244 19013(Tax:10090) Chemical Gene Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY Identification and mechanism of 10-carbon_fatty_acid as modulating ligand of peroxisome_proliferator-activated_receptors . 16126183 0 10-carbon_sugar 43,58 MSn 98,101 10-carbon sugar MSn null 4478 Chemical Gene derivatives|amod|START_ENTITY series|nmod|derivatives characterization|nmod|series characterization|nmod|spectrometry spectrometry|compound|END_ENTITY Structural characterization of a series of 10-carbon_sugar derivatives by electrospray-ionization MSn mass spectrometry . 2417572 1 10-carboxymethyl-9-acridanone 169,198 CMA 202,205 10-carboxymethyl-9-acridanone CMA MESH:C026430 12761(Tax:10090) Chemical Gene START_ENTITY|conj|END_ENTITY 9-oxo-10-acridineacetic_acid bearing the common name of 10-carboxymethyl-9-acridanone or CMA -LRB- 6 -RRB- was found to be a very potent interferon -LRB- IFN -RRB- inducer in adult Balb/c mice . 3081999 1 10-carboxymethyl-9-acridanone 294,323 IFN-alpha 237,246 10-carboxymethyl-9-acridanone IFN-alpha MESH:C026430 111654(Tax:10090) Chemical Gene inducers|nmod|START_ENTITY used|nsubjpass|inducers produce|advcl|used produce|dobj|END_ENTITY Besides the established T-cell property of producing gamma_interferon _ -LRB- IFN-gamma -RRB- , murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone -LRB- CMA -RRB- or Newcastle_disease virus -LRB- NDV -RRB- are used . 6181145 5 10-carboxymethyl-9-acridanone 827,856 IFN-alpha/beta 735,749 10-carboxymethyl-9-acridanone IFN-alpha/beta MESH:C026430 15977(Tax:10090) Chemical Gene virus_type_IFN|amod|START_ENTITY virus_type_IFN|appos|END_ENTITY When virus_type_IFN -LRB- IFN-alpha/beta -RRB- inducers , Newcastle_disease_virus , polyriboinosinic-polyribocytidylic_acid , 10-carboxymethyl-9-acridanone , and E. _ coli endotoxin , were administered to mice , no change in IFN response was observed after thermal_injury . 2596029 4 10-carboxymethyl-9-acridanone 748,777 IFN_beta 855,863 10-carboxymethyl-9-acridanone IFN beta MESH:C026430 15977(Tax:10090) Chemical Gene macrophages|nmod|START_ENTITY Induction|nmod|macrophages resulted|nsubj|Induction resulted|conj|100-fold 100-fold|nsubj|mRNAs mRNAs|conj|level level|compound|END_ENTITY Induction of macrophages with the synthetic inducer 10-carboxymethyl-9-acridanone resulted in small amounts of IFN_alpha 2 , alpha_4 , and alpha 6 mRNAs and the IFN_beta mRNA level was about 100-fold higher . 3081999 1 10-carboxymethyl-9-acridanone 294,323 IFN-beta 251,259 10-carboxymethyl-9-acridanone IFN-beta MESH:C026430 15977(Tax:10090) Chemical Gene inducers|nmod|START_ENTITY used|nsubjpass|inducers produce|advcl|used produce|dobj|IFN-alpha IFN-alpha|conj|END_ENTITY Besides the established T-cell property of producing gamma_interferon _ -LRB- IFN-gamma -RRB- , murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone -LRB- CMA -RRB- or Newcastle_disease virus -LRB- NDV -RRB- are used . 3081999 0 10-carboxymethyl-9-acridanone 64,93 interferon-beta 14,29 10-carboxymethyl-9-acridanone interferon-beta MESH:C026430 15977(Tax:10090) Chemical Gene induced|advcl|START_ENTITY induced|nsubj|Production Production|nmod|END_ENTITY Production of interferon-beta by murine T-cell lines induced by 10-carboxymethyl-9-acridanone . 28769808 1 10-Chloromethyl-11-demethyl-12-oxo-calanolide 88,133 F18 135,138 10-Chloromethyl-11-demethyl-12-oxo-calanolide F18 null 10046 Chemical Gene START_ENTITY|appos|END_ENTITY 10-Chloromethyl-11-demethyl-12-oxo-calanolide -LRB- F18 -RRB- , an analog of calanolide_A , is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1 . 22037848 2 10-chloromethyl-11-demethyl-12-oxo-calanolide_A 444,491 F18 493,496 10-chloromethyl-11-demethyl-12-oxo-calanolide A F18 MESH:C547679 10046 Chemical Gene START_ENTITY|appos|END_ENTITY We previously described a newly synthesized small molecule , 10-chloromethyl-11-demethyl-12-oxo-calanolide_A -LRB- F18 -RRB- , a -LRB- + -RRB- - calanolide_A analog , as a novel anti-HIV-1 NNRTI -LRB- H. Xue et al. , J. Med . 7104299 1 10-CHO-H4folate 406,421 AICAR 297,302 10-CHO-H4folate AICAR null 471 Chemical Gene donor|dep|START_ENTITY mechanism|nmod|donor purine|nmod|mechanism purine|dobj|proceeds proceeds|amod|catalyzed catalyzed|nmod|transformylase transformylase|conj|transformylase transformylase|appos|END_ENTITY It is shown that the transfer of formyl units in the de novo purine biosynthetic pathway as catalyzed by glycinamide_ribonucleotide -LRB- GAR -RRB- transformylase and 5-aminoimidazole-4-carboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase probably proceeds through a direct displacement mechanism involving only formyl donor -LRB- 10-CHO-H4folate -RRB- and formyl acceptor -LRB- GAR or AICAR -RRB- . 7104299 1 10-CHO-H4folate 406,421 AICAR 451,456 10-CHO-H4folate AICAR null 471 Chemical Gene donor|dep|START_ENTITY donor|appos|GAR GAR|conj|END_ENTITY It is shown that the transfer of formyl units in the de novo purine biosynthetic pathway as catalyzed by glycinamide_ribonucleotide -LRB- GAR -RRB- transformylase and 5-aminoimidazole-4-carboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase probably proceeds through a direct displacement mechanism involving only formyl donor -LRB- 10-CHO-H4folate -RRB- and formyl acceptor -LRB- GAR or AICAR -RRB- . 11383691 2 10-cis-heptadecenoic_acid 448,473 ALC 436,439 10-cis-heptadecenoic acid ALC null 55821 Chemical Gene incubated|nsubjpass|START_ENTITY and/or|acl:relcl|incubated and/or|appos|17:0 17:0|dep|END_ENTITY n-Heptadecanol -LRB- 17:0 - ALC -RRB- and/or 10-cis-heptadecenoic_acid -LRB- 17:1 - ACID -RRB- was incubated with liver homogenate of the six myctophid fishes and with co-factors such as NADPH and ATP for 2 to 5 h. Considerable amounts of wax esters with odd-numbered fatty_acids and/or alcohols were produced in the liver homogenate of the wax ester-rich species . 24586378 4 10-Cl-BBQ 866,875 AhR 889,892 10-Cl-BBQ AhR null 11622(Tax:10090) Chemical Gene Iso-quinolin-7-one|dep|START_ENTITY Iso-quinolin-7-one|dep|ligand ligand|nsubj|END_ENTITY We screened a ChemBridge small molecule library and identified 10-chloro-7H-benzimidazo -LSB- 2,1-a -RSB- benzo -LSB- de -RSB- Iso-quinolin-7-one -LRB- 10-Cl-BBQ -RRB- as a potent AhR ligand that was rapidly metabolized and not cytotoxic to proliferating T cells . 26573835 2 10-Cl-BBQ 517,526 AhR 550,553 10-Cl-BBQ AhR MESH:C000593972 11622(Tax:10090) Chemical Gene iso-quinolin-7-one|dep|START_ENTITY discovered|xcomp|iso-quinolin-7-one discovered|xcomp|ligand ligand|dep|END_ENTITY We recently discovered 10-chloro-7H-benzimidazo -LSB- 2,1-a -RSB- benzo -LSB- de -RSB- iso-quinolin-7-one -LRB- 10-Cl-BBQ -RRB- , a nanomolar affinity AhR ligand with immunosuppressive activity and favorable pharmacologic properties . 26573835 9 10-Cl-BBQ 1621,1630 AhR 1657,1660 10-Cl-BBQ AhR MESH:C000593972 11622(Tax:10090) Chemical Gene END_ENTITY|nsubj|START_ENTITY Taken together , 10-Cl-BBQ is an effective , nontoxic AhR ligand for the intervention of immune-mediated diseases that functions independently of Foxp3 -LRB- + -RRB- Tregs to suppress pathogenic T cell development . 26573835 0 10-Cl-BBQ 47,56 Aryl_Hydrocarbon_Receptor 18,43 10-Cl-BBQ Aryl Hydrocarbon Receptor MESH:C000593972 11622(Tax:10090) Chemical Gene Insulitis|amod|START_ENTITY END_ENTITY|nmod|Insulitis Activation of the Aryl_Hydrocarbon_Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3 + Regulatory T Cells in Nonobese Diabetic Mice . 26573835 0 10-Cl-BBQ 47,56 Foxp3 125,130 10-Cl-BBQ Foxp3 MESH:C000593972 20371(Tax:10090) Chemical Gene Insulitis|amod|START_ENTITY Insulitis|nmod|END_ENTITY Activation of the Aryl_Hydrocarbon_Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3 + Regulatory T Cells in Nonobese Diabetic Mice . 26573835 9 10-Cl-BBQ 1621,1630 Foxp3 1749,1754 10-Cl-BBQ Foxp3 MESH:C000593972 20371(Tax:10090) Chemical Gene AhR|nsubj|START_ENTITY AhR|acl|ligand ligand|ccomp|Tregs Tregs|nsubj|functions functions|nmod|END_ENTITY Taken together , 10-Cl-BBQ is an effective , nontoxic AhR ligand for the intervention of immune-mediated diseases that functions independently of Foxp3 -LRB- + -RRB- Tregs to suppress pathogenic T cell development . 11670058 7 10-Cl-XCbl 2951,2961 C10 2900,2903 10-Cl-XCbl C10 null 113246 Chemical Gene complexes|amod|START_ENTITY spectrum|nmod|complexes causes|nmod|spectrum causes|nsubj|Substitution Substitution|nmod|H H|nmod|Cl Cl|nmod|END_ENTITY Substitution of H by Cl at C10 causes the bands in the electronic spectrum of 10-Cl-XCbl complexes to move to lower energy , which is consistent with an increase in electron density in the corrin pi-conjugated system . 1399963 2 10-cmH2O 514,522 CO2 466,469 10-cmH2O CO2 null 717 Chemical Gene breathing|conj|START_ENTITY rebreathing|nmod|breathing studied|xcomp|rebreathing studied|nmod|END_ENTITY We studied 12 normal men during CO2 rebreathing while free breathing and with a 10-cmH2O . 18346930 4 10CpG 738,743 MAT1A 757,762 10CpG MAT1A null 11720(Tax:10090) Chemical Gene sites|amod|START_ENTITY sites|nmod|region region|compound|END_ENTITY Bisulfite genomic sequencing indicated that the methylation status of 10CpG sites in the MAT1A promoter proximal region was appreciably correlated with the gene expression in mouse developing liver and in adult hepatic cells ; hepatic stellate cells and hepatocytes . 5879171 2 10-Cyanosteroids 36,52 C-3 71,74 10-Cyanosteroids C-3 null 718 Chemical Gene START_ENTITY|nmod|END_ENTITY 10-Cyanosteroids with an oxygen at C-3 . 11279126 2 10-cysteine 417,428 follistatin 320,331 10-cysteine follistatin null 100774874 Chemical Gene domains|amod|START_ENTITY repeating|dobj|domains followed|xcomp|repeating segment|acl|followed comprised|nmod|segment comprised|nsubjpass|molecule molecule|compound|END_ENTITY The 288-residue follistatin molecule is comprised of a 63-residue N-terminal segment followed by three repeating 10-cysteine `` follistatin domains '' also represented in several extracellular matrix proteins . 11279126 2 10-cysteine 417,428 follistatin 430,441 10-cysteine follistatin null 100774874 Chemical Gene domains|amod|START_ENTITY domains|amod|END_ENTITY The 288-residue follistatin molecule is comprised of a 63-residue N-terminal segment followed by three repeating 10-cysteine `` follistatin domains '' also represented in several extracellular matrix proteins . 12595574 5 10-cysteine 921,932 follistatin 949,960 10-cysteine follistatin null 14313(Tax:10090) Chemical Gene repeat|amod|START_ENTITY repeat|acl|found found|nmod|END_ENTITY GASP-1 also contains a domain homologous to the 10-cysteine repeat found in follistatin , a protein that binds and inhibits activin , another member of the TGFbeta superfamily . 12595574 5 10-cysteine 921,932 GASP-1 873,879 10-cysteine GASP-1 null 278507(Tax:10090) Chemical Gene repeat|amod|START_ENTITY contains|nmod|repeat contains|dep|END_ENTITY GASP-1 also contains a domain homologous to the 10-cysteine repeat found in follistatin , a protein that binds and inhibits activin , another member of the TGFbeta superfamily . 18817775 3 10-DAB 482,488 Bcl-2 560,565 10-DAB Bcl-2 null 596 Chemical Gene Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|END_ENTITY Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same . 18817775 3 10-DAB 482,488 Caveolin-1 422,432 10-DAB Caveolin-1 null 857 Chemical Gene Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment observed|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same . 18817775 3 10-DAB 482,488 ERK1/2 529,535 10-DAB ERK1/2 null 5595;5594 Chemical Gene Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|Bcl-2 Bcl-2|compound|Raf-1 Raf-1|conj|END_ENTITY Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same . 18817775 3 10-DAB 482,488 Raf-1 522,527 10-DAB Raf-1 null 5894 Chemical Gene Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|Bcl-2 Bcl-2|compound|END_ENTITY Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same . 2428470 1 10-DAM 198,204 DHFR 332,336 10-DAM DHFR null 101121421 Chemical Gene methotrexate|appos|START_ENTITY derivatives|nmod|methotrexate tested|nsubjpass|derivatives tested|nmod|inhibitors inhibitors|nmod|dihydrofolate_reductase dihydrofolate_reductase|appos|END_ENTITY Polyglutamyl derivatives of methotrexate -LRB- MTX -RRB- and 10-deazaaminopterin -LRB- 10-DAM -RRB- containing a total of one through six glutamate residues -LRB- Glu residues -RRB- were tested as inhibitors of dihydrofolate_reductase -LRB- DHFR -RRB- derived from sheep , chicken , and beef liver . 2428470 1 10-DAM 198,204 dihydrofolate_reductase 307,330 10-DAM dihydrofolate reductase null 101121421 Chemical Gene methotrexate|appos|START_ENTITY derivatives|nmod|methotrexate tested|nsubjpass|derivatives tested|nmod|inhibitors inhibitors|nmod|END_ENTITY Polyglutamyl derivatives of methotrexate -LRB- MTX -RRB- and 10-deazaaminopterin -LRB- 10-DAM -RRB- containing a total of one through six glutamate residues -LRB- Glu residues -RRB- were tested as inhibitors of dihydrofolate_reductase -LRB- DHFR -RRB- derived from sheep , chicken , and beef liver . 17530898 4 10-DBC-8-Ade 749,761 10-DBC-8-Gua 766,778 10-DBC-8-Ade 10-DBC-8-Gua MESH:C114328 9188 Chemical Gene START_ENTITY|conj|END_ENTITY The C -LRB- 8 -RRB- - aryl adducts of adenine and guanine derived from BP -LRB- 6-BP-8-Ade and 6-BP-8-Gua -RRB- and DBC -LRB- 10-DBC-8-Ade and 10-DBC-8-Gua -RRB- were synthesized in good yields by this method . 26672353 0 10-Deacetyl_Baccatin 15,35 CO2 53,56 10-Deacetyl Baccatin CO2 null 717 Chemical Gene START_ENTITY|nmod|END_ENTITY -LSB- Extraction of 10-Deacetyl_Baccatin by Supercritical CO2 from Taxus yunnanensis Branches and Leaves -RSB- . 7529746 10 10-deacetylbaccatine 1608,1628 TNF 1544,1547 10-deacetylbaccatine TNF MESH:C042213 21926(Tax:10090) Chemical Gene III|amod|START_ENTITY not|conj|III not|nsubj|production production|compound|END_ENTITY Taxol-induced TNF production was not inhibited by colchicine , vinblastine , or 10-deacetylbaccatine III . 23352123 5 10-deacetyl_baccatin_III 1207,1231 mgl-1 1196,1201 10-deacetyl baccatin III mgl-1 MESH:C042213 3996 Chemical Gene Baccatin_III|conj|START_ENTITY Baccatin_III|appos|END_ENTITY Maximum yields of Baccatin_III -LRB- 10.03 mgl-1 -RRB- and 10-deacetyl_baccatin_III -LRB- 4.2 mgl-1 -RRB- were achieved from the DKW basal media , but the yield of Taxol was maximum -LRB- 16.58 mgl-1 -RRB- in the WPM basal media . 23352123 5 10-deacetyl_baccatin_III 1207,1231 mgl-1 1326,1331 10-deacetyl baccatin III mgl-1 MESH:C042213 3996 Chemical Gene Baccatin_III|conj|START_ENTITY yields|nmod|Baccatin_III achieved|nsubjpass|yields achieved|conj|maximum maximum|appos|END_ENTITY Maximum yields of Baccatin_III -LRB- 10.03 mgl-1 -RRB- and 10-deacetyl_baccatin_III -LRB- 4.2 mgl-1 -RRB- were achieved from the DKW basal media , but the yield of Taxol was maximum -LRB- 16.58 mgl-1 -RRB- in the WPM basal media . 23352123 7 10-deacetyl_baccatin_III 1568,1592 mgl-1 1530,1535 10-deacetyl baccatin III mgl-1 MESH:C042213 3996 Chemical Gene Taxol|conj|START_ENTITY Taxol|appos|END_ENTITY The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media . 23352123 7 10-deacetyl_baccatin_III 1568,1592 mgl-1 1556,1561 10-deacetyl baccatin III mgl-1 MESH:C042213 3996 Chemical Gene Taxol|conj|START_ENTITY Taxol|conj|Baccatin_III Baccatin_III|appos|END_ENTITY The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media . 23352123 7 10-deacetyl_baccatin_III 1568,1592 mgl-1 1599,1604 10-deacetyl baccatin III mgl-1 MESH:C042213 3996 Chemical Gene START_ENTITY|appos|END_ENTITY The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media . 10938416 0 10-deacetylbaccatin_III 25,48 C-10 68,72 10-deacetylbaccatin III C-10 MESH:C042213 3226 Chemical Gene START_ENTITY|xcomp|baccatin baccatin|nmod|deacetylase deacetylase|compound|END_ENTITY Enzymatic acetylation of 10-deacetylbaccatin_III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913 . 9891802 10 10-deacetylbaccatin_III 1684,1707 C-13 1727,1731 10-deacetylbaccatin III C-13 MESH:C042213 3229 Chemical Gene III|amod|START_ENTITY III|nmod|chain chain|compound|END_ENTITY The chemical coupling of 10-deacetylbaccatin_III or baccatin III to C-13 paclitaxel side chain has been summarized to prepare paclitaxel by semisynthesis . 9891802 5 10-deacetylbaccatin_III 845,868 C-13 889,893 10-deacetylbaccatin III C-13 MESH:C042213 3229 Chemical Gene START_ENTITY|dep|paclitaxel paclitaxel|nmod|chain chain|compound|END_ENTITY Three novel enzymes were discovered in our laboratory that converted the variety of taxanes to a single molecule , namely 10-deacetylbaccatin_III -LRB- paclitaxel without C-13 side chain and C-10_acetate -RRB- , a precursor for paclitaxel semisynthesis . 11451646 1 10-deacetylbaccatin_III 289,312 RP-2 264,268 10-deacetylbaccatin III RP-2 MESH:C042213 6102 Chemical Gene purpose|nmod|START_ENTITY gel|nmod|purpose gel|appos|END_ENTITY Solid-phase extraction was accomplished with specially prepared cartridges filled with silanised silica gel -LRB- RP-2 -RRB- for the purpose of 10-deacetylbaccatin_III -LRB- 10-DAB III -RRB- and related taxoids extracts purification obtained from different yew materials . 19795923 7 10-deacetyl-paclitaxel 1008,1030 CYP2C8 931,937 10-deacetyl-paclitaxel CYP2C8 MESH:C095360 1558 Chemical Gene metabolized|nsubjpass|START_ENTITY metabolized|advcl|showed showed|nsubj|END_ENTITY Although CYP2C8 showed a high capacity for metabolizing 7-epi-10-deacetyl-paclitaxel , 10-deacetyl-paclitaxel was hardly metabolized under the identical incubation conditions . 7915279 3 10-deacetyltaxol 693,709 C-13 586,590 10-deacetyltaxol C-13 MESH:C031494 3229 Chemical Gene paclitaxel|conj|START_ENTITY removed|advcl|paclitaxel removed|dobj|chain chain|compound|END_ENTITY A strain of Nocardioides albus -LRB- SC13911 -RRB- was isolated from soil and found to produce an extracellular enzyme that specifically removed the C-13 side chain from paclitaxel , cephalomannine , 7-beta-xylosyltaxol , 7-beta-xylosyl-10-deacetyltaxol , and 10-deacetyltaxol . 2369741 5 10-deazaaminopterin 862,881 C10 938,941 10-deazaaminopterin C10 MESH:C017178 14790(Tax:10090) Chemical Gene substitution|dep|START_ENTITY carbon|nmod|substitution aminopterin|conj|carbon Alkylation|nmod|aminopterin increased|nsubj|Alkylation increased|dobj|Km Km|acl|6-fold 6-fold|advcl|restored restored|nsubj|alkylation alkylation|nmod|_ _|compound|END_ENTITY Alkylation of aminopterin -LRB- methotrexate -RRB- or carbon for nitrogen substitution -LRB- 10-deazaaminopterin -RRB- at N-10 increased Km 3 - to 6-fold , while alkylation at C10 _ -LRB- 10-ethyl-10-deazaaminopterin -RRB- restored Km to near equivalency with aminopterin . 2428470 0 10-deazaaminopterin 57,76 dihydrofolate_reductase 101,124 10-deazaaminopterin dihydrofolate reductase MESH:C017178 101121421 Chemical Gene methotrexate|conj|START_ENTITY methotrexate|conj|dihydrofolate dihydrofolate|nmod|END_ENTITY Interaction of polyglutamyl derivatives of methotrexate , 10-deazaaminopterin , and dihydrofolate with dihydrofolate_reductase . 22280833 9 10-DEBC 779,786 Akt 752,755 10-DEBC Akt null 207 Chemical Gene FPA-124|conj|START_ENTITY FPA-124|compound|END_ENTITY The effects of the Akt inhibitors FPA-124 and 10-DEBC on phenylephrine - , noradrenaline - and electric field stimulation - -LRB- EFS - -RRB- induced contraction were studied in myographic measurements . 23194750 4 10-DEBC 952,959 Akt 961,964 10-DEBC Akt null 24185(Tax:10116) Chemical Gene START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY Isolated rat femoral arteries segments were mounted in a wire myograph and challenged with 100mM KCl or phenylephrine -LRB- PE -RRB- , in the absence or presence of troglitazone , rosiglitazone , pioglitazone , LY294002 -LRB- PI3K inhibitor -RRB- and 10-DEBC -LRB- Akt inhibitor -RRB- . 23194750 6 10-DEBC 1353,1360 Akt 1461,1464 10-DEBC Akt null 24185(Tax:10116) Chemical Gene thiazolidinediones|conj|START_ENTITY produced|nsubj|thiazolidinediones produced|dobj|decrease decrease|nmod|phosphorylation phosphorylation|compound|END_ENTITY Analysis of phospho-Akt -LRB- ser 473 -RRB- in lysates from rat arteries -LRB- by immunoblot -RRB- revealed that thiazolidinediones , LY294002 and 10-DEBC , at the same concentration and kinetics inhibiting vasoconstriction , produced a similar decrease of Akt phosphorylation . 27222231 9 10-DEBC 1178,1185 Akt 1203,1206 10-DEBC Akt null 207 Chemical Gene START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 . 25739982 6 10-DEBC 1085,1092 MEK1/2 1072,1078 10-DEBC MEK1/2 null 5604;5605 Chemical Gene END_ENTITY|conj|START_ENTITY U0126 -LRB- 5 M -RRB- , a specific inhibitor of -LRB- MEK1/2 -RRB- , and 10-DEBC -LRB- 2 M -RRB- , a selective inhibitor of AKT , both significantly reduced 17b-estradiol-induced phosphorylation of mTOR . 25739982 6 10-DEBC 1085,1092 mTOR 1201,1205 10-DEBC mTOR null 2475 Chemical Gene MEK1/2|conj|START_ENTITY inhibitor|nmod|MEK1/2 U0126|appos|inhibitor reduced|nsubj|U0126 reduced|dobj|phosphorylation phosphorylation|nmod|END_ENTITY U0126 -LRB- 5 M -RRB- , a specific inhibitor of -LRB- MEK1/2 -RRB- , and 10-DEBC -LRB- 2 M -RRB- , a selective inhibitor of AKT , both significantly reduced 17b-estradiol-induced phosphorylation of mTOR . 23194750 4 10-DEBC 952,959 PI3K 932,936 10-DEBC PI3K null 298947(Tax:10116) Chemical Gene KCl|conj|START_ENTITY KCl|nmod|absence absence|nmod|inhibitor inhibitor|compound|END_ENTITY Isolated rat femoral arteries segments were mounted in a wire myograph and challenged with 100mM KCl or phenylephrine -LRB- PE -RRB- , in the absence or presence of troglitazone , rosiglitazone , pioglitazone , LY294002 -LRB- PI3K inhibitor -RRB- and 10-DEBC -LRB- Akt inhibitor -RRB- . 27222231 9 10-DEBC 1178,1185 PI3K 1168,1172 10-DEBC PI3K null 5293 Chemical Gene LY294002|conj|START_ENTITY LY294002|dep|inhibitor inhibitor|nmod|END_ENTITY Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 . 27222231 9 10-DEBC 1178,1185 Skp2 1312,1316 10-DEBC Skp2 null 6502 Chemical Gene LY294002|conj|START_ENTITY reduced|nsubj|LY294002 reduced|conj|reduced reduced|dobj|expression expression|nmod|END_ENTITY Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 . 21114978 8 10-DEBC_hydrochloride 1488,1509 Akt 1428,1431 10-DEBC hydrochloride Akt null 207 Chemical Gene LY294002|amod|START_ENTITY inhibitor|dep|LY294002 activation|conj|inhibitor activation|compound|END_ENTITY On the other hand , metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC_hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects . 21114978 8 10-DEBC_hydrochloride 1488,1509 Akt 1474,1477 10-DEBC hydrochloride Akt null 207 Chemical Gene LY294002|amod|START_ENTITY inhibitor|dep|LY294002 inhibitor|compound|END_ENTITY On the other hand , metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC_hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects . 23111315 6 10-DEBC_hydrochloride 1349,1370 Akt 1344,1347 10-DEBC hydrochloride Akt null 207 Chemical Gene END_ENTITY|dep|START_ENTITY The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 23111315 6 10-DEBC_hydrochloride 1349,1370 AMPK 1240,1244 10-DEBC hydrochloride AMPK null 5564 Chemical Gene Akt|dep|START_ENTITY inhibitors|appos|Akt LC3b|conj|inhibitors LC3b|compound|mTOR mTOR|compound|END_ENTITY The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 23111315 6 10-DEBC_hydrochloride 1349,1370 AMPK 1325,1329 10-DEBC hydrochloride AMPK null 5564 Chemical Gene Akt|dep|START_ENTITY inhibitors|appos|Akt inhibitors|nmod|END_ENTITY The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 23111315 6 10-DEBC_hydrochloride 1349,1370 LC3b 1274,1278 10-DEBC hydrochloride LC3b null 81631 Chemical Gene Akt|dep|START_ENTITY inhibitors|appos|Akt END_ENTITY|conj|inhibitors The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 23111315 6 10-DEBC_hydrochloride 1349,1370 mTOR 1246,1250 10-DEBC hydrochloride mTOR null 2475 Chemical Gene Akt|dep|START_ENTITY inhibitors|appos|Akt LC3b|conj|inhibitors LC3b|compound|END_ENTITY The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 23111315 6 10-DEBC_hydrochloride 1349,1370 mTOR 1373,1377 10-DEBC hydrochloride mTOR null 2475 Chemical Gene Akt|dep|START_ENTITY inhibitors|appos|Akt inhibitors|appos|END_ENTITY The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts . 6355395 2 10-dehydogeniposide 394,413 C-8 200,203 10-dehydogeniposide C-8 null 3224 Chemical Gene deacetylasperulosidic_acid_methylester|conj|START_ENTITY gave|dobj|deacetylasperulosidic_acid_methylester provided|advcl|gave provided|nsubj|hydrolysis hydrolysis|appos|epimer epimer|nmod|position position|compound|END_ENTITY Enzymatic hydrolysis of galioside -LRB- 1 -RRB- and gardenoside -LRB- 2 -RRB- , epimer of 1 at C-8 position , provided the antimicrobially active aglucone -LRB- 3 -RRB- and the inactive 6 -LRB- a , b -RRB- , while acid treatment of 2 gave scandoside_methylester -LRB- 8 -RRB- , deacetylasperulosidic_acid_methylester -LRB- 9 -RRB- and 10-dehydogeniposide -LRB- 10 -RRB- . 24267247 1 10-dehydrogingerdione 187,208 CETP 167,171 10-dehydrogingerdione CETP MESH:C561631 100327267(Tax:9986) Chemical Gene investigate|nmod|START_ENTITY investigate|dobj|suppression suppression|compound|END_ENTITY OBJECTIVE : To investigate the CETP suppression by 10-dehydrogingerdione , a compound in Zingiber officinale , and its effect on the progression of atherosclerosis in dyslipidemic rabbits and the underlying oxidative and inflammatory consequences . 24267247 12 10-dehydrogingerdione 1707,1728 CETP 1774,1778 10-dehydrogingerdione CETP MESH:C561631 100327267(Tax:9986) Chemical Gene lowers|amod|START_ENTITY LDL-C|nsubj|lowers LDL-C|advcl|suppressing suppressing|dobj|END_ENTITY CONCLUSIONS : In a rabbit dyslipidemic_model , _ 10-dehydrogingerdione lowers LDL-C and raises HDL-C by suppressing CETP ; an effect that modulates inflammatory and oxidative risk factors of CVD . 24267247 13 10-dehydrogingerdione 1907,1928 CETP 1950,1954 10-dehydrogingerdione CETP MESH:C561631 100327267(Tax:9986) Chemical Gene inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY These findings suggested that the naturally occurring 10-dehydrogingerdione might be a potential CETP inhibitor for the treatment of atherosclerosis and residual risk in CVD . 25388083 3 10-dehydrogingerdione 456,477 CETP 494,498 10-dehydrogingerdione CETP MESH:C561631 100327267(Tax:9986) Chemical Gene START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY Therefore , 10-dehydrogingerdione -LRB- DHGD -RRB- , a novel CETP inhibitor isolated from ginger rhizomes , was selected as a natural product in the present study to illustrate its effect on haemostatic_impairment associated with hyperlipidemia as compared to a currently used hypocholesterolemic agent , atorvastatin -LRB- ATOR -RRB- . 24267247 11 10-dehydrogingerdione 1543,1564 MMP9 1622,1626 10-dehydrogingerdione MMP9 MESH:C561631 100008993(Tax:9986) Chemical Gene exerted|nsubj|START_ENTITY exerted|nmod|END_ENTITY However , 10-dehydrogingerdione exerted better effect than atorvastatin on homocysteine , MMP9 -LRB- p < 0.001 -RRB- and ox-LDL -LRB- p < 0.05 -RRB- . 24267247 7 10-dehydrogingerdione 974,995 MMP9 937,941 10-dehydrogingerdione MMP9 MESH:C561631 100008993(Tax:9986) Chemical Gene rabbits|amod|START_ENTITY decreased|nmod|rabbits ox-LDL|acl|decreased ox-LDL|conj|END_ENTITY Lp -LRB- a -RRB- , ox-LDL , hsCRP , homocysteine and MMP9 decreased significantly in both 10-dehydrogingerdione - and atorvastatin-treated rabbits compared with placebo -LRB- p < 0.001 -RRB- . 24267247 9 10-dehydrogingerdione 1232,1253 MMP9 1195,1199 10-dehydrogingerdione MMP9 MESH:C561631 100008993(Tax:9986) Chemical Gene returned|advcl|START_ENTITY returned|nsubj|END_ENTITY Conversely , MMP9 returned below normal values by 10-dehydrogingerdione -LRB- p < 0.001 -RRB- , hsCRP and ox-LDL were slightly below normal values -LRB- hsCRP : p < 0.001 ; ox-LDL : p < 0.001 and p < 0.05 in 10-dehydrogingerdione and atorvastatin groups , respectively -RRB- . 24267247 9 10-dehydrogingerdione 1371,1392 MMP9 1195,1199 10-dehydrogingerdione MMP9 MESH:C561631 100008993(Tax:9986) Chemical Gene groups|amod|START_ENTITY p|nmod|groups hsCRP|dep|p slightly|dep|hsCRP slightly|parataxis|returned returned|nsubj|END_ENTITY Conversely , MMP9 returned below normal values by 10-dehydrogingerdione -LRB- p < 0.001 -RRB- , hsCRP and ox-LDL were slightly below normal values -LRB- hsCRP : p < 0.001 ; ox-LDL : p < 0.001 and p < 0.05 in 10-dehydrogingerdione and atorvastatin groups , respectively -RRB- . 24267247 0 10-Dehydrogingerdione 0,21 CETP 55,59 10-Dehydrogingerdione CETP MESH:C561631 100327267(Tax:9986) Chemical Gene raises|nsubj|START_ENTITY raises|nmod|inhibition inhibition|compound|END_ENTITY 10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits . 11212122 1 10-deoxy-10-C-morpholinoethyl 125,154 P-glycoprotein 245,259 10-deoxy-10-C-morpholinoethyl P-glycoprotein null 5243 Chemical Gene analogues|amod|START_ENTITY cytotoxicity|nmod|analogues improve|dobj|cytotoxicity improve|nmod|lines lines|nmod|cells cells|acl|expressing expressing|dobj|P-gp P-gp|compound|END_ENTITY To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various_tumor cell lines including resistant cells expressing P-glycoprotein -LRB- P-gp -RRB- , we modified the 7-hydroxyl group to hydrophobic groups -LRB- methoxy , deoxy , 6,7-olefin , alpha-F , _ 7-beta-8-beta-methano , fluoromethoxy -RRB- . 11212122 1 10-deoxy-10-C-morpholinoethyl 125,154 P-gp 261,265 10-deoxy-10-C-morpholinoethyl P-gp null 5243 Chemical Gene analogues|amod|START_ENTITY cytotoxicity|nmod|analogues improve|dobj|cytotoxicity improve|nmod|lines lines|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various_tumor cell lines including resistant cells expressing P-glycoprotein -LRB- P-gp -RRB- , we modified the 7-hydroxyl group to hydrophobic groups -LRB- methoxy , deoxy , 6,7-olefin , alpha-F , _ 7-beta-8-beta-methano , fluoromethoxy -RRB- . 8691428 9 10-deoxydehydroryanodine 1436,1460 ryr 1215,1218 10-deoxydehydroryanodine ryr null 689560(Tax:10116) Chemical Gene epi-1|conj|START_ENTITY epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine . 16251298 4 10-deoxynystatin 869,885 C-10 936,940 10-deoxynystatin C-10 null 3226 Chemical Gene START_ENTITY|appos|precursor precursor|acl|lacking lacking|nmod|END_ENTITY Liquid chromatography-mass spectrometry and nuclear magnetic resonance structural analyses of the latter metabolite confirmed its identity as 10-deoxynystatin , a nystatin precursor lacking a hydroxyl group at C-10 . 7579732 3 10-dideazatetrahydrofolic_acid 676,706 mFBP 649,653 10-dideazatetrahydrofolic acid mFBP null 51886(Tax:10090) Chemical Gene -RSB-|amod|START_ENTITY 5|conj|-RSB- Antifolates|dep|5 Antifolates|acl:relcl|has has|nsubj|END_ENTITY Antifolates for which KB-derived mFBP has high affinity -LRB- 5 , 10-dideazatetrahydrofolic_acid -LSB- DDATHF -RSB- and homo-DDATHF -LSB- 0.24 and 0.78 respectively relative to folic_acid -RSB- -RRB- and low affinity -LRB- methotrexate -LSB- 0.002 -RSB- -RRB- were chosen for this study . 25862844 10 10-dihydroartemisinyl-2-propylpentanoate 1397,1437 VEGFR1 1353,1359 10-dihydroartemisinyl-2-propylpentanoate VEGFR1 null 2321 Chemical Gene dimer|conj|START_ENTITY found|nmod|dimer found|nsubjpass|affinities affinities|nmod|END_ENTITY The best binding affinities to VEGFR1 were found for an artemisinin dimer , 10-dihydroartemisinyl-2-propylpentanoate , and dihydroartemisinin_a-hemisuccinate_sodium salt . 22583689 0 10E12Z-CLA 23,33 COX-2 72,77 10E12Z-CLA COX-2 MESH:C496197 17709(Tax:10090) Chemical Gene expression|nummod|START_ENTITY fatty_acid|dobj|expression fatty_acid|nmod|synthesis synthesis|amod|dependent dependent|amod|END_ENTITY The dietary fatty_acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF -LRB- 2a -RRB- synthesis in adipocytes . 22583689 0 10E12Z-CLA 23,33 PGF 88,91 10E12Z-CLA PGF MESH:C496197 18654(Tax:10090) Chemical Gene expression|nummod|START_ENTITY fatty_acid|dobj|expression fatty_acid|nmod|synthesis synthesis|compound|END_ENTITY The dietary fatty_acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF -LRB- 2a -RRB- synthesis in adipocytes . 15176054 9 10E3-G4-D3 1156,1166 prostein 1217,1225 10E3-G4-D3 prostein null 85414 Chemical Gene utility|nmod|START_ENTITY indicating|dobj|utility specific|xcomp|indicating specific|conj|support support|dobj|use use|nmod|END_ENTITY CONCLUSIONS : Prostein is exquisitely specific for prostate tissues , indicating a potential clinical utility of 10E3-G4-D3 as a diagnostic biomarker , and support the use of prostein as a novel target for development of prostein-specific antibody and T-cell based therapeutic strategies for prostate_cancer . 15176054 9 10E3-G4-D3 1156,1166 Prostein 1058,1066 10E3-G4-D3 Prostein null 85414 Chemical Gene utility|nmod|START_ENTITY indicating|dobj|utility specific|xcomp|indicating specific|nsubj|END_ENTITY CONCLUSIONS : Prostein is exquisitely specific for prostate tissues , indicating a potential clinical utility of 10E3-G4-D3 as a diagnostic biomarker , and support the use of prostein as a novel target for development of prostein-specific antibody and T-cell based therapeutic strategies for prostate_cancer . 17944754 4 10E4 542,546 beta-catenin 576,588 10E4 beta-catenin MESH:C005629 1499 Chemical Gene HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 . 17944754 4 10E4 542,546 BMP-4 594,599 10E4 BMP-4 MESH:C005629 652 Chemical Gene HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 . 17944754 4 10E4 542,546 Wnt-2 569,574 10E4 Wnt-2 MESH:C005629 7472 Chemical Gene HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 . 17944754 4 10E4 542,546 Wnt-5a 561,567 10E4 Wnt-5a MESH:C005629 7474 Chemical Gene HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 . 1400325 4 10E5 939,943 RGDS 893,897 10E5 RGDS MESH:C005629 5900 Chemical Gene antibody|nummod|START_ENTITY peptide_Arg-Gly-Asp-Ser|conj|antibody peptide_Arg-Gly-Asp-Ser|appos|END_ENTITY Cytoskeletal association and platelet_aggregation were inhibited by the peptide_Arg-Gly-Asp-Ser -LRB- RGDS -RRB- -LRB- but not by Arg-Gly-Glu-Ser -LRB- RGES -RRB- -RRB- , by 10E5 antibody against glycoprotein -LRB- Gp -RRB- IIb/IIIa , and by EGTA . 1329249 5 10E5_heparin 1138,1150 RGDS 1030,1034 10E5 heparin RGDS MESH:C005629 5900 Chemical Gene enhance|nsubj|START_ENTITY platelet_aggregation|dep|enhance increased|nsubj|platelet_aggregation increased|nmod|pretreatment pretreatment|nmod|END_ENTITY Following pretreatment with RGDS , heparin increased platelet_aggregation -LRB- p less than 0.03 -RRB- , while after pretreatment with antibody MAb 10E5_heparin did not enhance platelet_aggregation . 2448650 6 10EdAM 1025,1031 MX-1 1109,1113 10EdAM MX-1 MESH:C040210 4599 Chemical Gene superiority|nmod|START_ENTITY shown|nsubjpass|superiority shown|nmod|xenografts xenografts|conj|END_ENTITY Marked superiority of 10EdAM compared to MTX was also shown against the following human tumor xenografts : MX-1 -LRB- mammary_carcinoma -RRB- , LX-1 -LRB- small_cell_lung_carcinoma -RRB- and CX-1 -LRB- colon_carcinoma -RRB- . 2448650 7 10EdAM 1196,1202 MX-1 1256,1260 10EdAM MX-1 MESH:C040210 4599 Chemical Gene produced|nsubj|START_ENTITY produced|dobj|regressions regressions|nmod|tumor tumor|compound|END_ENTITY 10EdAM produced 30 % to 40 % complete regressions against the MX-1 tumor . 1655252 10 10-EdAM 2498,2505 mFBP 2433,2437 10-EdAM mFBP MESH:C040210 51886(Tax:10090) Chemical Gene consistent|conj|START_ENTITY consistent|nmod|studies studies|nmod|cells cells|acl|demonstrating demonstrating|ccomp|played played|nsubj|END_ENTITY Results from affinity and membrane transport observations were consistent with growth inhibition studies on L1210-B73 cells demonstrating that the mFBP played only a minor role in the cytotoxic effects of MTX or 10-EdAM . 1655252 5 10-EdAM 1674,1681 mFBP 1568,1572 10-EdAM mFBP MESH:C040210 51886(Tax:10090) Chemical Gene MTX|conj|START_ENTITY affinity|nmod|MTX ICI-198|nmod|affinity affinity|conj|ICI-198 exhibited|dobj|affinity exhibited|nsubj|END_ENTITY The mFBP exhibited a high binding affinity for CB3717 and ICI-198 ,583 but a poor binding affinity for MTX and 10-EdAM . 1655252 6 10-EdAM 1853,1860 mFBP 1709,1713 10-EdAM mFBP MESH:C040210 51886(Tax:10090) Chemical Gene ICI-198|dep|START_ENTITY folic_acid|dobj|ICI-198 equal|xcomp|folic_acid decreased|conj|equal decreased|nsubj|affinities affinities|nmod|END_ENTITY Binding affinities of the mFBP decreased in the order CB3717 greater than or equal to folic_acid = ICI-198 ,583 greater than or equal to 5-CHO-THF much greater than MTX = 10-EdAM . 7641196 2 10-EdAM 1143,1150 mFBP 1015,1019 10-EdAM mFBP MESH:C040210 51886(Tax:10090) Chemical Gene ZD1694|amod|START_ENTITY acid|compound|ZD1694 MTX|appos|acid sensitive|nmod|MTX demonstrated|parataxis|sensitive demonstrated|dobj|lack lack|nmod|correlation correlation|nmod|affinity affinity|nmod|END_ENTITY Regardless of the medium folate status , growth inhibition studies with IGROV-I and MA104 cells demonstrated a lack of correlation between the affinity of mFBP for the antifolate drugs and their sensitivity profile ; both cell lines were highly sensitive to growth inhibition by MTX , 10-EdAM , ZD1694 and 5,10-dideazatetrahydrofolic _ acid , but were insensitive for CB3717 . 1655252 3 10-EdAM 1133,1140 thymidylate_synthase 1177,1197 10-EdAM thymidylate synthase MESH:C040210 22171(Tax:10090) Chemical Gene methotrexate|dep|START_ENTITY reductase|nmod|methotrexate inhibitors|nmod|reductase inhibitors|conj|inhibitors inhibitors|nmod|END_ENTITY The antifolates used were either inhibitors of dihydrofolate reductase , including methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazaaminopterin -LRB- 10-EdAM -RRB- , or two folate-based inhibitors of thymidylate_synthase , N10-propargyl-5 ,8 - dideazafolic_acid -LRB- CB3717 -RRB- and 2-deamino-2-methyl-N10-propargyl-5 ,8 - dideazafolic_acid -LRB- ICI-198 ,583 -RRB- . 2832548 1 10-EDAM 141,148 N10 233,236 10-EDAM N10 MESH:C040210 3164 Chemical Gene 10-ethyl-10-deaza-aminopterin|appos|START_ENTITY analog|nsubj|10-ethyl-10-deaza-aminopterin analog|acl:relcl|differs differs|nmod|modification modification|nmod|position position|compound|END_ENTITY 10-ethyl-10-deaza-aminopterin -LRB- 10-EDAM -RRB- is an analog of methotrexate that differs from its compound by modification of the N10 position and demonstrates greater preclinical antitumor activity and less toxicity . 11356934 3 10-epi-8-deoxycumambrin_B 522,547 aromatase 381,390 10-epi-8-deoxycumambrin B aromatase null 1588 Chemical Gene group|nmod|START_ENTITY reduced|dobj|group reduced|advcl|synthesize synthesize|nmod|specificity specificity|nmod|inhibition inhibition|amod|END_ENTITY To synthesize sesquiterpene_lactones with greater specificity for aromatase inhibition and lower cytotoxicity , we chemically reduced the alpha-methylene-gamma-lactone group in the active aromatase inhibitor 10-epi-8-deoxycumambrin_B -LRB- compound 1 -RRB- , to obtain the new compound 11betaH,13-dihydro-10-epi-8-deoxycumambrin _ B -LRB- compound 2 -RRB- . 11356934 3 10-epi-8-deoxycumambrin_B 522,547 aromatase 502,511 10-epi-8-deoxycumambrin B aromatase null 1588 Chemical Gene START_ENTITY|amod|END_ENTITY To synthesize sesquiterpene_lactones with greater specificity for aromatase inhibition and lower cytotoxicity , we chemically reduced the alpha-methylene-gamma-lactone group in the active aromatase inhibitor 10-epi-8-deoxycumambrin_B -LRB- compound 1 -RRB- , to obtain the new compound 11betaH,13-dihydro-10-epi-8-deoxycumambrin _ B -LRB- compound 2 -RRB- . 8691428 9 10-epi-amino 1351,1363 ryr 1215,1218 10-epi-amino ryr null 689560(Tax:10116) Chemical Gene epi-1|dep|START_ENTITY epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine . 8691428 9 10-epi-azidobenzoyl_hydrazide 1390,1419 ryr 1215,1218 10-epi-azidobenzoyl hydrazide ryr null 689560(Tax:10116) Chemical Gene derivatives|amod|START_ENTITY 10-epi-amino|conj|derivatives epi-1|dep|10-epi-amino epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine . 26947062 7 10-epi-cubebol 821,835 Sce6369 788,795 10-epi-cubebol Sce6369 null 5810909(Tax:448385) Chemical Gene synthase|amod|START_ENTITY END_ENTITY|appos|synthase In contrast , Sce6369 , the first characterized 10-epi-cubebol synthase , is responsible for the formation of most of the So_ce56 sesquiterpenes , mainly cadalanes and cubebanes . 8691428 9 10-epi-methoxyamino 1365,1384 ryr 1215,1218 10-epi-methoxyamino ryr null 689560(Tax:10116) Chemical Gene 10-epi-amino|conj|START_ENTITY epi-1|dep|10-epi-amino epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine . 23497874 2 10-epi-y-eudesmol 465,482 OGR1 382,386 10-epi-y-eudesmol OGR1 null 8111 Chemical Gene -1|conj|START_ENTITY levels|nmod|-1 constituted|dobj|levels constituted|nsubj|oil oil|nmod|END_ENTITY Essential oil from OGR1 was constituted high levels of -LRB- E -RRB- -1 - propenyl_sec-butyl_disulfide -LRB- 23.9 % -RRB- and 10-epi-y-eudesmol -LRB- 15.1 % -RRB- . 20962051 4 10-ethenyl-19-norprogesterone 1284,1313 mPRa 1270,1274 10-ethenyl-19-norprogesterone mPRa null 20200(Tax:10090) Chemical Gene agonist|amod|START_ENTITY agonist|compound|END_ENTITY Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa . 20962051 4 10-ethenyl-19-norprogesterone 1284,1313 mPRa 1408,1412 10-ethenyl-19-norprogesterone mPRa null 20200(Tax:10090) Chemical Gene agonist|amod|START_ENTITY mimicked|nsubj|agonist mimicked|dobj|action action|nmod|death death|acl:relcl|lost lost|nmod|knockdown knockdown|nmod|protein protein|compound|END_ENTITY Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa . 20962051 4 10-ethenyl-19-norprogesterone 1284,1313 mPRa 1508,1512 10-ethenyl-19-norprogesterone mPRa null 20200(Tax:10090) Chemical Gene agonist|amod|START_ENTITY mimicked|nsubj|agonist mimicked|dobj|action action|nmod|death death|acl:relcl|lost lost|xcomp|demonstrating demonstrating|dobj|involvement involvement|nmod|END_ENTITY Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa . 24530629 4 10-ethenyl-19-norprogesterone 726,755 mPRa 712,716 10-ethenyl-19-norprogesterone mPRa null 20200(Tax:10090) Chemical Gene agonist|appos|START_ENTITY agonist|compound|END_ENTITY The specific mPRa agonist , 10-ethenyl-19-norprogesterone -LRB- Org_OD 02-0 , 100nM -RRB- , mimicked the stimulatory actions of the endogenous progestin , _ 17,20 b , _ 21-trihydroxy-4-pregnen-3-one -LRB- 20b-S , 100nM -RRB- on flounder sperm motility . 24695628 3 10-ethenyl-19-norprogesterone 772,801 mPRalpha 755,763 10-ethenyl-19-norprogesterone mPRalpha null 20200(Tax:10090) Chemical Gene START_ENTITY|compound|END_ENTITY The specific mPRalpha agonist 10-ethenyl-19-norprogesterone -LRB- Org_OD 02-0 -RRB- mimicked the stimulatory actions of the endogenous progestin in this species , 17 , _ 20beta , _ 21-trihydroxy-4-pregnen-3-one -LRB- 20beta-S -RRB- , on sperm motility . 7057422 4 10-ethoxalylfolic_acid 545,567 THF 606,609 10-ethoxalylfolic acid THF MESH:C052091 21831(Tax:10090) Chemical Gene hydrogenation|nmod|START_ENTITY rearranged|nmod|hydrogenation rearranged|nsubj|product product|dep|EtO2CCO EtO2CCO|dep|END_ENTITY In the catalytic hydrogenation of 10-ethoxalylfolic_acid -LRB- 5 -RRB- , the initial product 10 - -LRB- EtO2CCO -RRB- - THF -LRB- 22 -RRB- rearranged readily to give 5 - -LRB- EtO2CCO -RRB- - THF -LRB- 21 -RRB- . 3978616 6 10-ethyl-10-deazaaminopterin 1625,1653 folylpolyglutamyl_synthetase 1765,1793 10-ethyl-10-deazaaminopterin folylpolyglutamyl synthetase MESH:C040210 14287(Tax:10090) Chemical Gene equal|nmod|START_ENTITY equal|xcomp|suggesting suggesting|ccomp|have have|nsubj|END_ENTITY In contrast , the relative rates of polyglutamylation in Manca cells were in the order 10-ethyl-10-deazaaminopterin approximately equal to aminopterin greater than 10-deazaaminopterin greater than methotrexate , suggesting that folylpolyglutamyl_synthetase may have varying substrate preferences in different cell types . 2369741 7 10-ethyl-10-deazaaminopterin 1380,1408 FPGS 1282,1286 10-ethyl-10-deazaaminopterin FPGS MESH:C040210 14287(Tax:10090) Chemical Gene 2-fold|dep|START_ENTITY similar|conj|2-fold similar|nsubj|Values Values|dep|derived derived|nmod|END_ENTITY Values for Vmax -LRB- derived with partially purified FPGS -RRB- for the other 4-aminofolate analogues and folic_acid were similar -LRB- methotrexate -RRB- or 2-fold -LRB- 10-ethyl-10-deazaaminopterin -RRB- and 5-fold -LRB- folic_acid -RRB- lower than for aminopterin . 11705857 10 10-ethyl-10-deazaaminopterin 1942,1970 hRFC 1777,1781 10-ethyl-10-deazaaminopterin hRFC MESH:C040210 6573 Chemical Gene Tomudex|conj|START_ENTITY substrates|nmod|Tomudex measured|nmod|substrates measured|advcl|were were|nsubj|differences differences|nmod|parameters parameters|nmod|transport transport|nmod|forms forms|amod|END_ENTITY Although there were no significant differences between the kinetic parameters for methotrexate transport for the hRFC forms , minor -LRB- approximately 2-fold -RRB- differences were measured in the K -LRB- i -RRB- s for other substrates including Tomudex , 5,10-dideazatetrahydrofolate , GW1843U89 , and 10-ethyl-10-deazaaminopterin and for 5-formyl_tetrahydrofolate . 1655252 3 10-ethyl-10-deazaaminopterin 1103,1131 thymidylate_synthase 1177,1197 10-ethyl-10-deazaaminopterin thymidylate synthase MESH:C040210 22171(Tax:10090) Chemical Gene methotrexate|conj|START_ENTITY reductase|nmod|methotrexate inhibitors|nmod|reductase inhibitors|conj|inhibitors inhibitors|nmod|END_ENTITY The antifolates used were either inhibitors of dihydrofolate reductase , including methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazaaminopterin -LRB- 10-EdAM -RRB- , or two folate-based inhibitors of thymidylate_synthase , N10-propargyl-5 ,8 - dideazafolic_acid -LRB- CB3717 -RRB- and 2-deamino-2-methyl-N10-propargyl-5 ,8 - dideazafolic_acid -LRB- ICI-198 ,583 -RRB- . 1831805 1 10-ethyl-10-deazaaminopterin 356,384 thymidylate_synthase 222,242 10-ethyl-10-deazaaminopterin thymidylate synthase MESH:C040210 29261(Tax:10116) Chemical Gene methotrexate|conj|START_ENTITY predict|nmod|methotrexate measures|advcl|predict measures|dobj|activity activity|amod|END_ENTITY A methylcholanthrene-induced rat_sarcoma propagated both in vitro and in vivo was used to examine the usefulness of a rapid biochemical in situ assay that measures thymidylate_synthase -LRB- TS -RRB- activity in whole cells to predict sensitivity and resistance to the folate antagonists methotrexate -LRB- MTX -RRB- , 10-ethyl-10-deazaaminopterin -LRB- 10-EDAM -RRB- and trimetrexate -LRB- TMTX -RRB- . 2832548 1 10-ethyl-10-deaza-aminopterin 110,139 N10 233,236 10-ethyl-10-deaza-aminopterin N10 MESH:C040210 3164 Chemical Gene analog|nsubj|START_ENTITY analog|acl:relcl|differs differs|nmod|modification modification|nmod|position position|compound|END_ENTITY 10-ethyl-10-deaza-aminopterin -LRB- 10-EDAM -RRB- is an analog of methotrexate that differs from its compound by modification of the N10 position and demonstrates greater preclinical antitumor activity and less toxicity . 7553969 1 10-ethyl-10-deazapterin 956,979 DHFR 862,866 10-ethyl-10-deazapterin DHFR null 1719 Chemical Gene potent|conj|START_ENTITY potent|conj|potent potent|nmod|inhibitors inhibitors|compound|END_ENTITY These new analogs are highly potent as DHFR and cell growth inhibitors , and most of them are more potent than methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazapterin -LRB- 10-EDAM -RRB- in inhibiting tumor cell growth -LRB- P388 MTX-sensitive and MTX-resistant , colon 26 and KB -RRB- on 72 h drug exposure . 7519382 0 10-ethyl-deaza-aminopterin 138,164 prostate-specific_antigen 23,48 10-ethyl-deaza-aminopterin prostate-specific antigen null 354 Chemical Gene trial|nmod|START_ENTITY change|dep|trial change|nmod|levels levels|amod|END_ENTITY Post-therapy change in prostate-specific_antigen levels as a clinical trial endpoint in hormone-refractory prostatic_cancer : a trial with 10-ethyl-deaza-aminopterin . 9092577 6 10-FDDF 1314,1321 FDH 1251,1254 10-FDDF FDH MESH:C092738 64392(Tax:10116) Chemical Gene activity|nummod|START_ENTITY occurred|nsubj|activity independent|advcl|occurred independent|nsubj|activity activity|nmod|domain domain|conj|END_ENTITY Aldehyde dehydrogenase activity of the COOH-terminal domain and FDH was independent of the presence of 2-mercaptoethanol while 10-FDDF dehydrogenase activity of FDH occurred only in the presence of 2-mercaptoethanol . 9092577 6 10-FDDF 1314,1321 FDH 1348,1351 10-FDDF FDH MESH:C092738 64392(Tax:10116) Chemical Gene activity|nummod|START_ENTITY activity|nmod|END_ENTITY Aldehyde dehydrogenase activity of the COOH-terminal domain and FDH was independent of the presence of 2-mercaptoethanol while 10-FDDF dehydrogenase activity of FDH occurred only in the presence of 2-mercaptoethanol . 18930948 2 10-fluoroethoxyphosphinyl-N-biotinamido_pentyldecanamide 382,438 transferrin 289,300 10-fluoroethoxyphosphinyl-N-biotinamido pentyldecanamide transferrin MESH:C403065 7018 Chemical Gene modified|nmod|START_ENTITY modified|nsubjpass|END_ENTITY However , transferrin , a protein with no active site serine , was covalently modified in vitro by 0.5 mM 10-fluoroethoxyphosphinyl-N-biotinamido_pentyldecanamide , chlorpyrifos_oxon , diisopropylfluorophosphate , dichlorvos , sarin , and soman . 1989499 1 10-formylfolate 112,127 thymidylate_synthase 175,195 10-formylfolate thymidylate synthase null 7298 Chemical Gene derivatives|nmod|START_ENTITY evaluated|nsubjpass|derivatives evaluated|nmod|inhibitors inhibitors|nmod|END_ENTITY Reduced derivatives of 10-formylfolate have been evaluated as inhibitors of mammalian thymidylate_synthase -LRB- EC 2.1.1.45 -RRB- from H35 hepatoma cells . 10985775 7 10-formyl-folate 1696,1712 AICAR 1682,1687 10-formyl-folate AICAR null 471 Chemical Gene cofactor|amod|START_ENTITY END_ENTITY|conj|cofactor We have determined the equilibrium constant of the transformylase reaction to be 0.024 + / - 0.001 , showing that the reaction strongly favors AICAR and the 10-formyl-folate cofactor . 3366769 3 10-formyl-H2folate 797,815 AICAR 886,891 10-formyl-H2folate AICAR null 471 Chemical Gene examined|nsubjpass|START_ENTITY examined|nmod|interaction interaction|conj|transformylase transformylase|amod|END_ENTITY Chemically synthesized monoglutamated or pentaglutamated 10-formyl-H2folate was examined for its interaction with three folate-dependent enzymes : AICAR transformylase , glucinamide_ribotide -LRB- GAR -RRB- transformylase , and thymidylatesynthase . 3366769 8 10-formyl-H2folate 1710,1728 AICAR 1951,1956 10-formyl-H2folate AICAR null 471 Chemical Gene role|nmod|START_ENTITY determined|nsubjpass|role has|advcl|determined has|dobj|potential potential|acl|enhance enhance|dobj|inhibition inhibition|nmod|GAR GAR|conj|time time|dep|provides provides|dobj|substrate substrate|nmod|transformylase transformylase|amod|END_ENTITY While the actual role of 10-formyl-H2folate contributing to the cytotoxicity of MTX has not been determined , this compound has the potential to enhance inhibition of GAR transformylase and thymidylate_synthase , and at the same time provides additional substrate for AICAR transformylase . 3366769 6 10-formyl-H2folate 1416,1434 thymidylate_synthase 1392,1412 10-formyl-H2folate thymidylate synthase null 7298 Chemical Gene END_ENTITY|nmod|START_ENTITY The inhibition of thymidylate_synthase by 10-formyl-H2folate was highly dependent on the inhibitor 's polyglutamation state , the - Glu5 derivative having a 52-85-fold greater affinity as compared to the affinity of - Glu1 . 3366769 8 10-formyl-H2folate 1710,1728 thymidylate_synthase 1874,1894 10-formyl-H2folate thymidylate synthase null 7298 Chemical Gene role|nmod|START_ENTITY determined|nsubjpass|role has|advcl|determined has|dobj|potential potential|acl|enhance enhance|dobj|inhibition inhibition|nmod|GAR GAR|amod|transformylase transformylase|conj|END_ENTITY While the actual role of 10-formyl-H2folate contributing to the cytotoxicity of MTX has not been determined , this compound has the potential to enhance inhibition of GAR transformylase and thymidylate_synthase , and at the same time provides additional substrate for AICAR transformylase . 3366769 9 10-formyl-H2folate 2019,2037 thymidylate_synthase 2163,2183 10-formyl-H2folate thymidylate synthase null 7298 Chemical Gene accumulation|nmod|START_ENTITY play|nsubj|accumulation play|nmod|inhibition inhibition|nmod|END_ENTITY The MTX-induced intracellular accumulation of 10-formyl-H2folate and H2folate may play a role in the drug-related cytotoxicity through the contribution of these folates to the inhibition of thymidylate_synthase and de novo purine synthesis . 3091098 5 10-formyl-H4folate 847,865 cystathionine_beta-synthase 943,970 10-formyl-H4folate cystathionine beta-synthase null 875 Chemical Gene synthetase|amod|START_ENTITY cycle|conj|synthetase enzymes|nmod|cycle enzymes|conj|END_ENTITY We also measured the activities of another three enzymes of the folic_acid cycle , viz. , 5,10-methylene-H4folate dehydrogenase , 10-formyl-H4folate synthetase , and 5,10-methenyl-H4folate cyclohydrolase , as well as the enzyme cystathionine_beta-synthase . 3366769 5 10-formyl-H4folate-Glu5 1349,1372 AICAR 1247,1252 10-formyl-H4folate-Glu5 AICAR null 471 Chemical Gene that|nmod|START_ENTITY equal|nmod|that acted|conj|equal acted|nmod|substrate substrate|nmod|transformylase transformylase|amod|END_ENTITY It acted as a substrate for AICAR transformylase -LRB- Km = 5.3 microM -RRB- , and its efficiency was equal to that of the natural substrate 10-formyl-H4folate-Glu5 . 6351556 1 10-formyl-H4PteGlu 399,417 thymidylate_synthase 338,358 10-formyl-H4PteGlu thymidylate synthase null 7298 Chemical Gene synthetase|amod|START_ENTITY END_ENTITY|conj|synthetase In the past few years we have been engaged in studying several folate cofactor requiring enzymes derived from human cells ; namely thymidylate_synthase , dihydrofolate reductase , folyl binder , 10-formyl-H4PteGlu synthetase , 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase . 6351556 3 10-formyl-H4PteGlu 739,757 thymidylate_synthase 717,737 10-formyl-H4PteGlu thymidylate synthase null 7298 Chemical Gene synthetase|amod|START_ENTITY substrates|conj|synthetase substrates|nmod|END_ENTITY Folylpolyglutamates are better substrates for thymidylate_synthase , 10-formyl-H4PteGlu synthetase , and 5,10-methylene-H4PteGlu dehydrogenase when NADP is lower than 30 microM , whereas dihydrofolate reductase and membrane associated folyl binder do not distinguish between folylmono - _ and_polyglutamates . 6351556 0 10-formyl-H4PteGlu 61,79 Thymidylate_synthase 0,20 10-formyl-H4PteGlu Thymidylate synthase null 7298 Chemical Gene synthetase|amod|START_ENTITY reductase|conj|synthetase derived|nsubj|reductase derived|advmod|END_ENTITY Thymidylate_synthase , dihydrofolate reductase , folyl binder , 10-formyl-H4PteGlu synthetase , 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase derived from cells of human origin . 11320079 1 10-formyltetrahydrofolate 220,245 10-formyltetrahydrofolate_dehydrogenase 164,203 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 10840 Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|enzyme enzyme|appos|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction . 3392008 2 10-formyltetrahydrofolate 399,424 10-formyltetrahydrofolate_dehydrogenase 257,296 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene activity|amod|START_ENTITY copurifying|dobj|activity presence|acl|copurifying indicated|dobj|presence indicated|nsubj|studies studies|nmod|END_ENTITY Previous studies of 10-formyltetrahydrofolate_dehydrogenase purified from rat or pig liver homogenized in phosphate buffers indicated the presence of copurifying 10-formyltetrahydrofolate hydrolase activity , which catalyzes conversion of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 3392008 2 10-formyltetrahydrofolate 475,500 10-formyltetrahydrofolate_dehydrogenase 257,296 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion activity|acl:relcl|catalyzes copurifying|dobj|activity presence|acl|copurifying indicated|dobj|presence indicated|nsubj|studies studies|nmod|END_ENTITY Previous studies of 10-formyltetrahydrofolate_dehydrogenase purified from rat or pig liver homogenized in phosphate buffers indicated the presence of copurifying 10-formyltetrahydrofolate hydrolase activity , which catalyzes conversion of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 7822273 1 10-formyltetrahydrofolate 235,260 10-formyltetrahydrofolate_dehydrogenase 120,159 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY enzyme|dep|oxidation enzyme|appos|catalyzes catalyzes|amod|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 7822273 1 10-formyltetrahydrofolate 331,356 10-formyltetrahydrofolate_dehydrogenase 120,159 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY enzyme|dep|hydrolysis enzyme|appos|catalyzes catalyzes|amod|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 7972060 3 10-formyltetrahydrofolate 583,608 10-formyltetrahydrofolate_dehydrogenase 524,563 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 107747(Tax:10090) Chemical Gene DH|dep|START_ENTITY identified|dep|DH identified|nmod|forms forms|nmod|END_ENTITY Characterization of this protein_deficiency has identified these liver proteins as forms of the enzyme 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-formyl-THF DH ; 10-formyltetrahydrofolate : NADP + oxidoreductase , EC 1.5.1.6 -RRB- . 8527931 1 10-formyltetrahydrofolate 241,266 10-formyltetrahydrofolate_dehydrogenase 116,155 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY NADP|dep|oxidation reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 8527931 1 10-formyltetrahydrofolate 337,362 10-formyltetrahydrofolate_dehydrogenase 116,155 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY NADP|dep|hydrolysis reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 9092577 1 10-formyltetrahydrofolate 300,325 10-formyltetrahydrofolate_dehydrogenase 183,222 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene +|amod|START_ENTITY oxidation|nmod|+ reactions|dep|oxidation catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 9092577 1 10-formyltetrahydrofolate 394,419 10-formyltetrahydrofolate_dehydrogenase 183,222 10-formyltetrahydrofolate 10-formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY reactions|dep|hydrolysis catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 14729668 1 10-formyltetrahydrofolate 218,243 10-Formyltetrahydrofolate_dehydrogenase 163,202 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- converts 10-formyltetrahydrofolate , a precursor for nucleotide biosynthesis , to tetrahydrofolate . 17302434 1 10-formyltetrahydrofolate 293,318 10-Formyltetrahydrofolate_dehydrogenase 168,207 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene conversion|nmod|START_ENTITY resulting|nmod|conversion reaction|acl|resulting +|dep|reaction catalyzes|dobj|+ catalyzes|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- catalyzes an NADP + - dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 24747731 3 10-formyltetrahydrofolate 409,434 10-Formyltetrahydrofolate_dehydrogenase 360,399 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 100526683 Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 , the only pathway responsible for formate oxidation in methanol intoxication . 25849409 1 10-formyltetrahydrofolate 372,397 10-Formyltetrahydrofolate_dehydrogenase 183,222 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 100526683 Chemical Gene converts|xcomp|START_ENTITY enzyme|conj|converts enzyme|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 . 3392008 1 10-formyltetrahydrofolate 182,207 10-Formyltetrahydrofolate_dehydrogenase 86,125 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- EC 1.5.1.6 -RRB- catalyzes the NADP-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 3392008 5 10-formyltetrahydrofolate 977,1002 10-Formyltetrahydrofolate_dehydrogenase 878,917 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene activity|amod|START_ENTITY has|dobj|activity has|nsubj|purified purified|amod|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase purified from the mannitol/sucrose/EDTA supernatant has no 10-formyltetrahydrofolate hydrolase activity . 7646059 1 10-formyltetrahydrofolate 193,218 10-Formyltetrahydrofolate_dehydrogenase 83,122 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate . 7929148 1 10-formyltetrahydrofolate 159,184 10-Formyltetrahydrofolate_dehydrogenase 74,113 10-formyltetrahydrofolate 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY catalyzes|dep|oxidation catalyzes|amod|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate . 7822273 1 10-formyltetrahydrofolate 235,260 10-FTHFDH 161,170 10-formyltetrahydrofolate 10-FTHFDH MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY enzyme|dep|oxidation enzyme|appos|catalyzes catalyzes|amod|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|dep|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 7822273 1 10-formyltetrahydrofolate 331,356 10-FTHFDH 161,170 10-formyltetrahydrofolate 10-FTHFDH MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY enzyme|dep|hydrolysis enzyme|appos|catalyzes catalyzes|amod|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|dep|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 8527931 1 10-formyltetrahydrofolate 241,266 10-FTHFDH 157,166 10-formyltetrahydrofolate 10-FTHFDH MESH:C010161 64392(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY NADP|dep|oxidation reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 8527931 1 10-formyltetrahydrofolate 337,362 10-FTHFDH 157,166 10-formyltetrahydrofolate 10-FTHFDH MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY NADP|dep|hydrolysis reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 3366769 2 10-formyltetrahydrofolate 526,551 AICAR 717,722 10-formyltetrahydrofolate AICAR MESH:C010161 471 Chemical Gene H4folate|amod|START_ENTITY reduction|nmod|H4folate marker|conj|reduction marker|conj|deformylation deformylation|acl|dihydrofolate dihydrofolate|nmod|presence presence|nmod|transformylase transformylase|appos|END_ENTITY Its identity was verified by coelution of this compound with a synthetic marker on high pressure liquid chromatography , its reduction to 10-formyltetrahydrofolate -LRB- H4folate -RRB- in the presence of dihydrofolate reductase , and its enzymatic deformylation to dihydrofolate in the presence of aminoimidazolecarboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase . 9143321 2 10-formyltetrahydrofolate 399,424 AICAR 387,392 10-formyltetrahydrofolate AICAR MESH:C010161 471 Chemical Gene using|xcomp|START_ENTITY END_ENTITY|acl|using This reaction involves the formylation of AICAR using 10-formyltetrahydrofolate as the formyl donor . 18848533 1 10-formyltetrahydrofolate 143,168 Aldh1L1 113,120 10-formyltetrahydrofolate Aldh1L1 MESH:C010161 10840 Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|FDH FDH|appos|dehydrogenase dehydrogenase|dep|END_ENTITY FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 18848533 1 10-formyltetrahydrofolate 72,97 Aldh1L1 113,120 10-formyltetrahydrofolate Aldh1L1 MESH:C010161 10840 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 28414156 1 10-formyltetrahydrofolate 164,189 ALDH1L1 64,71 10-formyltetrahydrofolate ALDH1L1 MESH:C010161 10840 Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nsubj|END_ENTITY ALDH1L1 , a member of the aldehyde dehydrogenase superfamily of enzymes , catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 20498374 0 10-formyltetrahydrofolate 40,65 ALDH1L2 0,7 10-formyltetrahydrofolate ALDH1L2 MESH:C010161 160428 Chemical Gene dehydrogenase|amod|START_ENTITY homolog|nmod|dehydrogenase homolog|nsubj|END_ENTITY ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase . 11430769 8 10-formyltetrahydrofolate 1815,1840 C-6 1642,1645 10-formyltetrahydrofolate C-6 MESH:C010161 729 Chemical Gene oxidation|nmod|START_ENTITY withstand|nmod|oxidation withstand|nsubj|dogma dogma|dep|bioactive bioactive|nsubj|dose dose|nmod|isomer isomer|compound|END_ENTITY The dogma that an oral dose of the unnatural C-6 isomer of 5-formyltetrahydrofolate is not bioactive in human subjects does not withstand scrutiny , most probably due to the previously unrecognized in vivo oxidation of 10-formyltetrahydrofolate . 16597835 4 10-formyltetrahydrofolate 672,697 CO2 725,728 10-formyltetrahydrofolate CO2 MESH:C010161 717 Chemical Gene oxidation|nmod|START_ENTITY activity|dep|oxidation produces|dobj|activity produces|nmod|THF THF|conj|END_ENTITY Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 . 19933275 4 10-formyltetrahydrofolate 770,795 CO2 820,823 10-formyltetrahydrofolate CO2 MESH:C010161 717 Chemical Gene conversion|nmod|START_ENTITY allows|dobj|conversion allows|nmod|tetrahydrofolate tetrahydrofolate|conj|END_ENTITY This moiety acts as a swinging arm to couple the activities of the two catalytic domains of FDH and allows the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 28414156 1 10-formyltetrahydrofolate 164,189 CO2 214,217 10-formyltetrahydrofolate CO2 MESH:C010161 717 Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nmod|tetrahydrofolate tetrahydrofolate|conj|END_ENTITY ALDH1L1 , a member of the aldehyde dehydrogenase superfamily of enzymes , catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 11556805 1 10-formyltetrahydrofolate 237,262 cytosolic_10-formyltetrahydrofolate_dehydrogenase 83,132 10-formyltetrahydrofolate cytosolic 10-formyltetrahydrofolate dehydrogenase MESH:C010161 107747(Tax:10090) Chemical Gene form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|advcl|END_ENTITY NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc . 11320079 1 10-formyltetrahydrofolate 220,245 FDH 205,208 10-formyltetrahydrofolate FDH MESH:C010161 10840 Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|enzyme enzyme|appos|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction . 11556805 1 10-formyltetrahydrofolate 237,262 FDH 134,137 10-formyltetrahydrofolate FDH MESH:C010161 107747(Tax:10090) Chemical Gene form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|dep|END_ENTITY NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc . 14729668 1 10-formyltetrahydrofolate 218,243 FDH 204,207 10-formyltetrahydrofolate FDH MESH:C010161 64392(Tax:10116) Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- converts 10-formyltetrahydrofolate , a precursor for nucleotide biosynthesis , to tetrahydrofolate . 16597835 4 10-formyltetrahydrofolate 672,697 FDH 604,607 10-formyltetrahydrofolate FDH MESH:C010161 10840 Chemical Gene oxidation|nmod|START_ENTITY activity|dep|oxidation produces|dobj|activity produces|nsubj|action action|nmod|domains domains|nmod|END_ENTITY Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 . 17302434 1 10-formyltetrahydrofolate 293,318 FDH 209,212 10-formyltetrahydrofolate FDH MESH:C010161 64392(Tax:10116) Chemical Gene conversion|nmod|START_ENTITY resulting|nmod|conversion reaction|acl|resulting +|dep|reaction catalyzes|dobj|+ catalyzes|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- catalyzes an NADP + - dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 18848533 1 10-formyltetrahydrofolate 143,168 FDH 67,70 10-formyltetrahydrofolate FDH MESH:C010161 10840 Chemical Gene converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 18848533 1 10-formyltetrahydrofolate 72,97 FDH 67,70 10-formyltetrahydrofolate FDH MESH:C010161 10840 Chemical Gene dehydrogenase|amod|START_ENTITY END_ENTITY|appos|dehydrogenase FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 19933275 4 10-formyltetrahydrofolate 770,795 FDH 737,740 10-formyltetrahydrofolate FDH MESH:C010161 10840 Chemical Gene conversion|nmod|START_ENTITY allows|dobj|conversion acts|conj|allows acts|dobj|activities activities|nmod|domains domains|nmod|END_ENTITY This moiety acts as a swinging arm to couple the activities of the two catalytic domains of FDH and allows the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 . 25849409 1 10-formyltetrahydrofolate 372,397 FDH 224,227 10-formyltetrahydrofolate FDH MESH:C010161 100526683 Chemical Gene converts|xcomp|START_ENTITY enzyme|conj|converts enzyme|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 . 9092577 1 10-formyltetrahydrofolate 300,325 FDH 224,227 10-formyltetrahydrofolate FDH MESH:C010161 64392(Tax:10116) Chemical Gene +|amod|START_ENTITY oxidation|nmod|+ reactions|dep|oxidation catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 9092577 1 10-formyltetrahydrofolate 394,419 FDH 224,227 10-formyltetrahydrofolate FDH MESH:C010161 64392(Tax:10116) Chemical Gene hydrolysis|nmod|START_ENTITY reactions|dep|hydrolysis catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate . 3196754 0 10-formyltetrahydrofolate 18,43 folate_binding_protein 79,101 10-formyltetrahydrofolate folate binding protein MESH:C010161 25134(Tax:10116) Chemical Gene dehydrogenase-hydrolase|amod|START_ENTITY Identification|nmod|dehydrogenase-hydrolase Identification|nmod|END_ENTITY Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate_binding_protein in liver cytosol . 985432 17 10-formyltetrahydrofolate 1787,1812 formyltetrahydrofolate_dehydrogenase 1877,1913 10-formyltetrahydrofolate formyltetrahydrofolate dehydrogenase MESH:C010161 64392(Tax:10116) Chemical Gene increase|nmod|START_ENTITY causes|dobj|increase causes|dep|accelerates accelerates|dobj|reaction reaction|amod|END_ENTITY 18B , 793-798 -RSB- , that this inhibition causes an increase in the concentration of methylenetetrahydrofolate and the C1_tetrahydrofolate derivatives in equilibrium with methylenetetrahydrofolate , including 10-formyltetrahydrofolate ; that the increased concentration of the latter accelerates the formyltetrahydrofolate_dehydrogenase reaction , because the normal concentration of the substrate is far below the Km value of the enzyme for the substrate . 19007868 4 10-formyltetrahydrofolate 914,939 GART 883,887 10-formyltetrahydrofolate GART MESH:C010161 100689446 Chemical Gene requires|xcomp|START_ENTITY requires|nsubj|activity activity|amod|END_ENTITY The GART activity of GART requires 10-formyltetrahydrofolate and has been a target for anti-cancer drugs . 19007868 4 10-formyltetrahydrofolate 914,939 GART 900,904 10-formyltetrahydrofolate GART MESH:C010161 100689446 Chemical Gene requires|xcomp|START_ENTITY requires|nsubj|activity activity|nmod|END_ENTITY The GART activity of GART requires 10-formyltetrahydrofolate and has been a target for anti-cancer drugs . 25633902 1 10-formyltetrahydrofolate 331,356 MTHFD1 172,178 10-formyltetrahydrofolate MTHFD1 MESH:C010161 4522 Chemical Gene activity|amod|START_ENTITY dehydrogenase|conj|activity containing|dobj|dehydrogenase enzyme|acl|containing enzyme|nmod|END_ENTITY UNASSIGNED : In the folate cycle MTHFD1 , encoded by MTHFD1 , is a trifunctional enzyme containing 5,10-methylenetetrahydrofolate dehydrogenase , 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activity . 25633902 1 10-formyltetrahydrofolate 331,356 MTHFD1 191,197 10-formyltetrahydrofolate MTHFD1 MESH:C010161 4522 Chemical Gene activity|amod|START_ENTITY dehydrogenase|conj|activity containing|dobj|dehydrogenase enzyme|acl|containing enzyme|dep|encoded encoded|nmod|END_ENTITY UNASSIGNED : In the folate cycle MTHFD1 , encoded by MTHFD1 , is a trifunctional enzyme containing 5,10-methylenetetrahydrofolate dehydrogenase , 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activity . 19022216 5 10-formyltetrahydrofolate 867,892 MTHFS 831,836 10-formyltetrahydrofolate MTHFS MESH:C010161 10588 Chemical Gene availability|nmod|START_ENTITY increases|dobj|availability increases|nsubj|END_ENTITY This finding supports a mechanism whereby MTHFS increases the availability of 10-formyltetrahydrofolate for GARFT . 12024029 3 10-formyltetrahydrofolate 568,593 NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase 398,491 10-formyltetrahydrofolate NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase MESH:C010161 10797 Chemical Gene 5,10-methylenetetrahydrofolate|conj|START_ENTITY interconversion|acl|5,10-methylenetetrahydrofolate catalyzes|dobj|interconversion catalyzes|nsubj|END_ENTITY NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase -LRB- NMDMC -RRB- catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells , but its metabolic role is not yet clear . 11556805 1 10-formyltetrahydrofolate 237,262 NEUT2 55,60 10-formyltetrahydrofolate NEUT2 MESH:C010161 107747(Tax:10090) Chemical Gene form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|nsubj|mice mice|compound|END_ENTITY NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc . 12024029 11 10-formyltetrahydrofolate 1675,1700 NMDMC 1655,1660 10-formyltetrahydrofolate NMDMC MESH:C010161 17768(Tax:10090) Chemical Gene provide|xcomp|START_ENTITY provide|nsubj|role role|acl|postulated postulated|nmod|END_ENTITY One role postulated for NMDMC is to provide 10-formyltetrahydrofolate as a formyl group donor for the synthesis of this formylmethionyl-tRNA -LRB- fmet -RRB- . 12024029 3 10-formyltetrahydrofolate 568,593 NMDMC 493,498 10-formyltetrahydrofolate NMDMC MESH:C010161 10797 Chemical Gene 5,10-methylenetetrahydrofolate|conj|START_ENTITY interconversion|acl|5,10-methylenetetrahydrofolate catalyzes|dobj|interconversion catalyzes|nsubj|NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase|appos|END_ENTITY NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase -LRB- NMDMC -RRB- catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells , but its metabolic role is not yet clear . 1848231 9 10-formyltetrahydrofolate 1249,1274 phosphoribosylglycinamide_formyltransferase 1166,1209 10-formyltetrahydrofolate phosphoribosylglycinamide formyltransferase MESH:C010161 288259(Tax:10116) Chemical Gene region|nmod|START_ENTITY proposed|nsubjpass|region discussed|conj|proposed discussed|nsubjpass|identity identity|nmod|END_ENTITY The sequence identity to phosphoribosylglycinamide_formyltransferase is discussed , and a binding region for 10-formyltetrahydrofolate is proposed . 3734324 1 10-formyltetrahydrofolate 139,164 thymidylate_synthase 288,308 10-formyltetrahydrofolate thymidylate synthase MESH:C010161 22171(Tax:10090) Chemical Gene determination|nmod|START_ENTITY method|nmod|determination described|nsubjpass|method described|advcl|complex complex|acl|formed formed|nmod|methylenetetrahydrofolate methylenetetrahydrofolate|conj|END_ENTITY A radioenzymatic method for the determination of tissue 10-formyltetrahydrofolate is described based on the stable ternary complex formed from methylenetetrahydrofolate , tritiated_fluorodeoxyuridylate and thymidylate_synthase . 9749667 3 10-formyl_tetrahydrofolate 462,488 Bas2p 626,631 10-formyl tetrahydrofolate Bas2p MESH:C010161 851452(Tax:4932) Chemical Gene glutamine|conj|START_ENTITY shows|amod|glutamine synthesis|nmod|shows required|nmod|synthesis required|ccomp|repressed repressed|conj|requires requires|dobj|Baslp Baslp|conj|END_ENTITY Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p . 9749667 3 10-formyl_tetrahydrofolate 462,488 MTD1 505,509 10-formyl tetrahydrofolate MTD1 MESH:C010161 853955(Tax:4932) Chemical Gene glutamine|conj|START_ENTITY shows|amod|glutamine shows|dep|GLN1 GLN1|conj|END_ENTITY Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p . 9749667 3 10-formyl_tetrahydrofolate 462,488 SHM2 496,500 10-formyl tetrahydrofolate SHM2 MESH:C010161 850747(Tax:4932) Chemical Gene glutamine|conj|START_ENTITY shows|amod|glutamine shows|dep|GLN1 GLN1|conj|END_ENTITY Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p . 889710 6 10-formyl-tetrahydrofolate 843,869 peak_2 800,806 10-formyl-tetrahydrofolate peak 2 MESH:C010161 157285 Chemical Gene represent|xcomp|START_ENTITY unknown|conj|represent unknown|nsubj|nature nature|nmod|END_ENTITY The nature of peak_2 is unknown but peak 3 may represent 10-formyl-tetrahydrofolate . 21238436 1 10-Formyltetrahydrofolate 90,115 aldehyde_dehydrogenase 256,278 10-Formyltetrahydrofolate aldehyde dehydrogenase MESH:C010161 17035736 Chemical Gene dehydrogenase|amod|START_ENTITY shares|nsubj|dehydrogenase shares|nmod|enzymes enzymes|nmod|family family|amod|END_ENTITY 10-Formyltetrahydrofolate dehydrogenase -LRB- FDH , ALDH1L1 -RRB- , an abundant cytosolic enzyme of folate metabolism , shares significant sequence similarity with enzymes of the aldehyde_dehydrogenase -LRB- ALDH -RRB- family . 21238436 1 10-Formyltetrahydrofolate 90,115 ALDH 280,284 10-Formyltetrahydrofolate ALDH MESH:C010161 17035736 Chemical Gene dehydrogenase|amod|START_ENTITY shares|nsubj|dehydrogenase shares|nmod|enzymes enzymes|nmod|family family|appos|END_ENTITY 10-Formyltetrahydrofolate dehydrogenase -LRB- FDH , ALDH1L1 -RRB- , an abundant cytosolic enzyme of folate metabolism , shares significant sequence similarity with enzymes of the aldehyde_dehydrogenase -LRB- ALDH -RRB- family . 27404357 7 10-formyl-tetrahydrofolate-Glun_and_dihydropteroate 952,1003 FOLR-1 896,902 10-formyl-tetrahydrofolate-Glun and dihydropteroate FOLR-1 null 182740(Tax:6239) Chemical Gene required|advcl|START_ENTITY required|nsubjpass|END_ENTITY The folate receptor homolog FOLR-1 is required for the stimulation of germ cells by 10-formyl-tetrahydrofolate-Glun_and_dihydropteroate . 1989499 0 10-formyltetrahydropteroylpolyglutamate 48,87 thymidylate_synthase 24,44 10-formyltetrahydropteroylpolyglutamate thymidylate synthase null 7298 Chemical Gene Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY Inhibition of mammalian thymidylate_synthase by 10-formyltetrahydropteroylpolyglutamate . 16365037 10 10-formylTHF 1498,1510 MTHFS 1426,1431 10-formylTHF MTHFS CHEBI:15637 10588 Chemical Gene facilitates|amod|START_ENTITY indicating|dobj|facilitates biosynthesis|xcomp|indicating enhances|ccomp|biosynthesis enhances|nsubj|END_ENTITY Isotope tracer studies in neuroblastoma demonstrate that MTHFS enhances de novo purine biosynthesis , indicating that MTHFS-bound 10-formylTHF facilitates de novo purine biosynthesis . 16365037 11 10-formylTHF 1594,1606 MTHFS 1585,1590 10-formylTHF MTHFS CHEBI:15637 10588 Chemical Gene END_ENTITY|nmod|START_ENTITY Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF , providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells . 16365037 11 10-formylTHF 1673,1685 MTHFS 1585,1590 10-formylTHF MTHFS CHEBI:15637 10588 Chemical Gene presence|nmod|START_ENTITY accumulate|nmod|presence indicates|ccomp|accumulate indicates|nsubj|regulation regulation|nmod|END_ENTITY Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF , providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells . 16365037 12 10-formylTHF 1821,1833 MTHFS 1837,1842 10-formylTHF MTHFS CHEBI:15637 10588 Chemical Gene START_ENTITY|nmod|END_ENTITY The sequestration of 10-formylTHF by MTHFS may explain why de novo purine biosynthesis is protected from common disruptions in the folate-dependent one-carbon network . 16365037 7 10-formylTHF 1047,1059 MTHFS 1164,1169 10-formylTHF MTHFS CHEBI:15637 107885(Tax:10090) Chemical Gene acts|nsubj|START_ENTITY acts|nmod|inhibitor inhibitor|nmod|END_ENTITY Steady-state kinetic studies revealed that 10-formylTHF , which exists in chemical equilibrium with 5,10-methenylTHF , acts as a tight binding inhibitor of mouse MTHFS . 16365037 9 10-formylTHF 1333,1345 MTHFS 1303,1308 10-formylTHF MTHFS CHEBI:15637 10588 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY MTHFS is the first identified 10-formylTHF tight-binding protein . 22303332 13 10-formylTHF 2153,2165 MTHFS 2104,2109 10-formylTHF MTHFS CHEBI:15637 107885(Tax:10090) Chemical Gene delivering|xcomp|START_ENTITY enhances|advcl|delivering enhances|nsubj|END_ENTITY The results from this study indicate that MTHFS enhances purine biosynthesis by delivering 10-formylTHF to the purinosome in a SUMO-dependent fashion . 11320079 1 10-formyl-THF 247,260 10-formyltetrahydrofolate_dehydrogenase 164,203 10-formyl-THF 10-formyltetrahydrofolate dehydrogenase CHEBI:15637 10840 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|enzyme enzyme|appos|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction . 7972060 3 10-formyl-THF 565,578 10-formyltetrahydrofolate_dehydrogenase 524,563 10-formyl-THF 10-formyltetrahydrofolate dehydrogenase CHEBI:15637 107747(Tax:10090) Chemical Gene DH|amod|START_ENTITY identified|dep|DH identified|nmod|forms forms|nmod|END_ENTITY Characterization of this protein_deficiency has identified these liver proteins as forms of the enzyme 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-formyl-THF DH ; 10-formyltetrahydrofolate : NADP + oxidoreductase , EC 1.5.1.6 -RRB- . 2233711 6 10-formyl-THF 1183,1196 ade3 1214,1218 10-formyl-THF ade3 CHEBI:15637 853118(Tax:4932) Chemical Gene synthetase|amod|START_ENTITY synthetase|nmod|strain strain|amod|END_ENTITY Heterologous expression of the Clostridium_acidiurici gene encoding a monofunctional 10-formyl-THF synthetase in an ade3 deletion strain did not restore growth in the absence of adenine , even though the monofunctional synthetase was catalytically competent in vivo . 8608153 5 10-formyl-THF 1082,1095 ade3 1178,1182 10-formyl-THF ade3 CHEBI:15637 853118(Tax:4932) Chemical Gene levels|nmod|START_ENTITY revealed|dobj|levels used|ccomp|revealed used|nmod|strain strain|amod|END_ENTITY Direct measurements of cellular folate coenzyme levels revealed substantial levels of 10-formyl-THF -LRB- CHO-THF -RRB- , the one-carbon donor used in purine synthesis , in the purine-requiring ade3 deletion strain . 2233711 2 10-formyl-THF 580,593 ADE3 460,464 10-formyl-THF ADE3 CHEBI:15637 853118(Tax:4932) Chemical Gene donor|amod|START_ENTITY synthesis|nmod|donor responsible|nmod|synthesis responsible|nsubj|enzyme enzyme|acl|encoded encoded|nmod|gene gene|compound|END_ENTITY This trifunctional enzyme , encoded by the ADE3 gene in the yeast Saccharomyces_cerevisiae , is thought to be responsible for the synthesis of the one-carbon donor 10-formyl-THF for de novo purine synthesis . 2233711 3 10-formyl-THF 727,740 ADE3 640,644 10-formyl-THF ADE3 CHEBI:15637 853118(Tax:4932) Chemical Gene lack|nmod|START_ENTITY result|nmod|lack causes|nmod|result causes|nsubj|Deletion Deletion|nmod|gene gene|compound|END_ENTITY Deletion of the ADE3 gene causes adenine auxotrophy , presumably as a result of the lack of cytoplasmic 10-formyl-THF . 2679653 8 10-formyl-THF 1328,1341 ADE3 1236,1240 10-formyl-THF ADE3 CHEBI:15637 853118(Tax:4932) Chemical Gene synthetase|amod|START_ENTITY encoding|dobj|synthetase encoding|advcl|encoding shown|xcomp|encoding shown|nmod|gene gene|compound|END_ENTITY The feasibility and versatility of the method is shown with the yeast ADE3 gene encoding the cytoplasmic C1-THF synthase and the gene encoding the monofunctional 10-formyl-THF synthetase from Clostridium_acidiurici . 8464869 1 10-formyl-THF 240,253 ADE3 87,91 10-formyl-THF ADE3 CHEBI:15637 853118(Tax:4932) Chemical Gene synthetase|amod|START_ENTITY possesses|dobj|synthetase synthase|acl:relcl|possesses identified|nmod|synthase identified|nsubjpass|product product|nmod|gene gene|compound|END_ENTITY The protein product of the ADE3 gene of the yeast Saccharomyces_cerevisiae has been identified as the cytoplasmic trifunctional C1-tetrahydrofolate -LRB- THF -RRB- synthase , which possesses 10-formyl-THF synthetase -LRB- EC 6.3.4.3 -RRB- , 5,10-methenyl-THF cyclohydrolase -LRB- EC 3.5.4.9 -RRB- , and 5,10-methylene-THF dehydrogenase -LRB- EC 1.5.1.5 -RRB- activities . 18848533 1 10-formyl-THF 170,183 Aldh1L1 113,120 10-formyl-THF Aldh1L1 MESH:C006461 10840 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|FDH FDH|appos|dehydrogenase dehydrogenase|dep|END_ENTITY FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 16597835 4 10-formyl-THF 699,712 CO2 725,728 10-formyl-THF CO2 CHEBI:15637 717 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate activity|dep|oxidation produces|dobj|activity produces|nmod|THF THF|conj|END_ENTITY Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 . 26567272 5 10-formyl-THF 739,752 CO2 867,870 10-formyl-THF CO2 CHEBI:15637 717 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|acl:relcl|oxidizes oxidizes|nmod|END_ENTITY The key enzyme for these mechanisms is 10-formyl-THF -LRB- tetrahydrofolate -RRB- dehydrogenase -LRB- both mitochondrial and cytoplasmic isoforms -RRB- which oxidizes the formyl group to CO2 with the attendant reduction of NADP -LRB- + -RRB- to NADPH and release of THF . 11320079 1 10-formyl-THF 247,260 FDH 205,208 10-formyl-THF FDH CHEBI:15637 10840 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|enzyme enzyme|appos|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction . 11320079 3 10-formyl-THF 639,652 FDH 568,571 10-formyl-THF FDH CHEBI:15637 10840 Chemical Gene utilizing|xcomp|START_ENTITY enzymes|acl|utilizing shares|nmod|enzymes shares|nsubj|domain domain|nmod|END_ENTITY The amino-terminal domain of FDH shares some sequence identity with several other enzymes utilizing 10-formyl-THF as a substrate . 16597835 3 10-formyl-THF 511,524 FDH 442,445 10-formyl-THF FDH CHEBI:15637 10840 Chemical Gene utilize|xcomp|START_ENTITY homolog|acl:relcl|utilize homolog|nsubj|domain domain|nmod|END_ENTITY The amino-terminal hydrolase domain of FDH -LRB- Nt-FDH -RRB- is a homolog of formyl transferase enzymes that utilize 10-formyl-THF as a formyl donor . 16597835 4 10-formyl-THF 699,712 FDH 604,607 10-formyl-THF FDH CHEBI:15637 10840 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate activity|dep|oxidation produces|dobj|activity produces|nsubj|action action|nmod|domains domains|nmod|END_ENTITY Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 . 16627483 8 10-formyl-THF 1663,1676 FDH 1457,1460 10-formyl-THF FDH CHEBI:15637 10840 Chemical Gene conversion|nmod|START_ENTITY catalyzing|dobj|conversion deplete|advcl|catalyzing facilitates|advcl|deplete facilitates|nsubj|expression expression|compound|END_ENTITY We conclude that low FDH expression facilitates the incorporation of one-carbon units into the one-carbon pool , whereas high levels of FDH expression deplete the folate-activated one-carbon pool by catalyzing the conversion of 10-formyl-THF to THF . 18848533 1 10-formyl-THF 170,183 FDH 67,70 10-formyl-THF FDH MESH:C006461 10840 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|END_ENTITY FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction . 10781559 4 10-formyl-THF 810,823 FMT1 906,910 10-formyl-THF FMT1 CHEBI:15637 852270(Tax:4932) Chemical Gene synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|methionyl-tRNA_formyltransferase methionyl-tRNA_formyltransferase|appos|YBL013W YBL013W|dep|END_ENTITY We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- . 10781559 3 10-formyl-THF 594,607 methionyl-tRNA_formyltransferase 492,524 10-formyl-THF methionyl-tRNA formyltransferase CHEBI:15637 852270(Tax:4932) Chemical Gene formyltetrahydrofolate|dep|START_ENTITY N|dep|formyltetrahydrofolate uses|dobj|N catalyzed|conj|uses catalyzed|nmod|END_ENTITY The formylation reaction is catalyzed by methionyl-tRNA_formyltransferase -LRB- MTF -RRB- located in mitochondria and uses N -LRB- 10 -RRB- - formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- as the formyl donor . 10781559 4 10-formyl-THF 810,823 methionyl-tRNA_formyltransferase 833,865 10-formyl-THF methionyl-tRNA formyltransferase CHEBI:15637 852270(Tax:4932) Chemical Gene synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|END_ENTITY We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- . 10781559 4 10-formyl-THF 810,823 MIS1 776,780 10-formyl-THF MIS1 CHEBI:15637 852378(Tax:4932) Chemical Gene synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|appos|END_ENTITY We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- . 19033438 2 10-formyl-THF 523,536 Mthfd1 350,356 10-formyl-THF Mthfd1 CHEBI:15637 108156(Tax:10090) Chemical Gene catalyzes|nmod|START_ENTITY point|acl:relcl|catalyzes point|nsubj|synthase synthase|acl|encoded encoded|nmod|END_ENTITY C1_tetrahydrofolate _ -LRB- THF -RRB- _ synthase , encoded by Mthfd1 , is an entry point of 1Cs into folate metabolism through its formyl-THF synthetase -LRB- FTHFS -RRB- activity that catalyzes the ATP-dependent conversion of formate and THF to 10-formyl-THF . 19948730 5 10-formyl-THF 881,894 MTHFD1L 907,914 10-formyl-THF MTHFD1L MESH:C006461 270685(Tax:10090) Chemical Gene synthetase|amod|START_ENTITY synthetase|appos|product product|nummod|END_ENTITY A monofunctional 10-formyl-THF synthetase -LRB- MTHFD1L gene product -RRB- functions in adult mitochondria and is a likely candidate for the embryonic activity . 23267094 5 10-formyl-THF 855,868 MTHFD1L 736,743 10-formyl-THF MTHFD1L CHEBI:15637 270685(Tax:10090) Chemical Gene producing|advcl|START_ENTITY catalyzes|advcl|producing catalyzes|nsubj|END_ENTITY In both embryos and adults , MTHFD1L catalyzes the last step in the flow of one-carbon units from mitochondria to cytoplasm , producing formate from 10-formyl-THF . 16597835 3 10-formyl-THF 511,524 Nt-FDH 447,453 10-formyl-THF Nt-FDH CHEBI:15637 10840 Chemical Gene utilize|xcomp|START_ENTITY homolog|acl:relcl|utilize homolog|nsubj|domain domain|appos|END_ENTITY The amino-terminal hydrolase domain of FDH -LRB- Nt-FDH -RRB- is a homolog of formyl transferase enzymes that utilize 10-formyl-THF as a formyl donor . 16597835 6 10-formyl-THF 1087,1100 Nt-FDH 1068,1074 10-formyl-THF Nt-FDH CHEBI:15637 10840 Chemical Gene enzymes|amod|START_ENTITY enzymes|compound|END_ENTITY The second was to explore the molecular basis for the distinct catalytic mechanisms of Nt-FDH and related 10-formyl-THF utilizing enzymes . 10781559 4 10-formyl-THF 810,823 YBL013W 886,893 10-formyl-THF YBL013W CHEBI:15637 852270(Tax:4932) Chemical Gene synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|methionyl-tRNA_formyltransferase methionyl-tRNA_formyltransferase|appos|END_ENTITY We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- . 25849409 1 10-FTHF 399,406 10-Formyltetrahydrofolate_dehydrogenase 183,222 10-FTHF 10-Formyltetrahydrofolate dehydrogenase MESH:C010161 100526683 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate enzyme|conj|converts enzyme|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 . 25849409 1 10-FTHF 399,406 FDH 224,227 10-FTHF FDH MESH:C010161 100526683 Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate enzyme|conj|converts enzyme|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 . 24962868 7 10G 1293,1296 STAT3 1346,1351 10G STAT3 null 6774 Chemical Gene 10-gingerol|appos|START_ENTITY 6-gingerol|conj|10-gingerol analogues|nmod|6-gingerol found|advcl|analogues found|xcomp|blocker blocker|nmod|activation activation|compound|END_ENTITY Compared with other analogues of 6SG , such as 6-gingerol -LRB- 6G -RRB- , 8-gingerol -LRB- 8G -RRB- , and 10-gingerol -LRB- 10G -RRB- , 6SG was found to be the most potent blocker of STAT3 activation . 15068071 1 10_g_alpha-lactalbumin 266,288 alpha-lactalbumin 139,156 10 g alpha-lactalbumin alpha-lactalbumin MESH:C506422 281894(Tax:9913) Chemical Gene /|amod|START_ENTITY solutions|nmod|/ incubation|nmod|solutions investigated|nmod|incubation investigated|nsubjpass|Details Details|nmod|hydrolysis hydrolysis|nmod|END_ENTITY Details in the hydrolysis of alpha-lactalbumin known to result in formation of highly ordered nanotubules , was investigated by incubation of solutions with 10_g_alpha-lactalbumin / l with a specific protease from Bacillus_licheniformis -LRB- BLP -RRB- . 22761764 9 10-gingerol 1396,1407 bmp2b 1464,1469 10-gingerol bmp2b MESH:C007845 30632(Tax:7955) Chemical Gene ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|nmod|expression expression|amod|END_ENTITY We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 . 22761764 9 10-gingerol 1396,1407 bmp7a 1474,1479 10-gingerol bmp7a MESH:C007845 30584(Tax:7955) Chemical Gene ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|nmod|expression expression|amod|bmp2b bmp2b|conj|END_ENTITY We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 . 17561453 3 10-gingerol 602,613 C-8 714,717 10-gingerol C-8 MESH:C007845 3224 Chemical Gene 6-Gingerol|conj|START_ENTITY extracted|csubjpass|6-Gingerol extracted|conj|analyzed analyzed|nmod|column column|amod|reversed reversed|amod|END_ENTITY 6-Gingerol , 6-shogaol , 8-gingerol , and 10-gingerol were extracted from various ginger-containing products with ethyl_acetate and analyzed by HPLC on a C-8 reversed phase column at 282 nm . 20837112 5 10-gingerol 676,687 COX-1 736,741 10-gingerol COX-1 MESH:C007845 4512 Chemical Gene inhibit|dep|START_ENTITY inhibit|xcomp|END_ENTITY Therefore , 10-gingerol , 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1 , which can explain , in part , the anti-inflammatory properties of ginger . 20837112 3 10-gingerol 511,522 COX-2 559,564 10-gingerol COX-2 MESH:C007845 4513 Chemical Gene Purified|xcomp|START_ENTITY Purified|dep|inhibited inhibited|dobj|values values|amod|END_ENTITY Purified 10-gingerol , 8-shogaol and 10-shogaol inhibited COX-2 with IC -LRB- 50 -RRB- values of 32 M , 17.5 M and 7.5 M , respectively . 20837112 5 10-gingerol 676,687 COX-2 722,727 10-gingerol COX-2 MESH:C007845 4513 Chemical Gene inhibit|dep|START_ENTITY inhibit|xcomp|COX-1 COX-1|dep|END_ENTITY Therefore , 10-gingerol , 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1 , which can explain , in part , the anti-inflammatory properties of ginger . 23770984 8 10-gingerol 1141,1152 CYP3A4 1206,1212 10-gingerol CYP3A4 MESH:C007845 1576 Chemical Gene 8-gingerol|conj|START_ENTITY inhibited|dep|8-gingerol inhibited|conj|induced induced|dobj|expression expression|nmod|END_ENTITY In HepG2 cells , 8-gingerol and 10-gingerol inhibited , but 6-gingerol induced mRNA expression of CYP3A4 . 22761764 9 10-gingerol 1396,1407 eve1 1534,1538 10-gingerol eve1 MESH:C007845 30335(Tax:7955) Chemical Gene ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|conj|effectors effectors|conj|END_ENTITY We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 . 22761764 6 10-gingerol 957,968 gata1 804,809 10-gingerol gata1 MESH:C007845 30481(Tax:7955) Chemical Gene component|amod|START_ENTITY identified|dobj|component utilized|conj|identified utilized|dobj|END_ENTITY METHODOLOGY/PRINCIPAL FINDINGS : Here , we utilized gata1 : dsRed transgenic zebrafish embryos to investigate the effect of ginger extract on hematopoiesis in vivo and we identified its bioactive component , 10-gingerol . 22761764 7 10-gingerol 999,1010 gata1 1037,1042 10-gingerol gata1 MESH:C007845 30481(Tax:7955) Chemical Gene ginger|conj|START_ENTITY promote|nsubj|ginger promote|dobj|expression expression|nmod|END_ENTITY We confirmed that ginger and 10-gingerol promote the expression of gata1 in erythroid cells and increase the expression of hematopoietic progenitor markers cmyb and scl . 22761764 9 10-gingerol 1396,1407 gata2 1524,1529 10-gingerol gata2 MESH:C007845 30480(Tax:7955) Chemical Gene ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|conj|effectors effectors|conj|END_ENTITY We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 . 21846463 5 10-gingerol 636,647 ghrelin 689,696 10-gingerol ghrelin MESH:C007845 59301(Tax:10116) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|deacylation deacylation|compound|END_ENTITY In addition , 10-gingerol , a component of RKT , inhibited exogenous ghrelin deacylation . 28872603 9 10-gingerol 1180,1191 GST 1298,1301 10-gingerol GST MESH:C007845 373156 Chemical Gene 6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|MRP1 MRP1|conj|END_ENTITY Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression . 22761764 10 10-gingerol 1567,1578 lmo2 1614,1618 10-gingerol lmo2 MESH:C007845 30332(Tax:7955) Chemical Gene ginger|conj|START_ENTITY stages|amod|ginger induce|nsubj|stages induce|dobj|expression expression|compound|scl scl|conj|END_ENTITY At later stages ginger and 10-gingerol can induce bmp2b/7a , cmyb , scl and lmo2 expression in the caudal hematopoietic tissue area . 28872603 9 10-gingerol 1180,1191 MRP1 1289,1293 10-gingerol MRP1 MESH:C007845 4363 Chemical Gene 6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression . 22540971 8 10-gingerol 1246,1257 NK1 1332,1335 10-gingerol NK1 MESH:C007845 6869 Chemical Gene 6-gingerol|conj|START_ENTITY phytochemicals|amod|6-gingerol function|nsubj|phytochemicals function|xcomp|antihistaminic antihistaminic|nsubj|antagonist antagonist|appos|antagonist antagonist|nummod|END_ENTITY The exact mechanism responsible for the anti-emetic effects of ginger is unknown ; however , the ginger phytochemicals , especially 6-gingerol , 8-gingerol , 10-gingerol , and 6-shogaol , may function as a 5-hydroxytryptamine -LRB- 5-HT3 -RRB- antagonist , NK1 antagonist , antihistaminic , and possess prokinetic effects . 28872603 6 10-gingerol 742,753 PC3 934,937 10-gingerol PC3 MESH:C007845 5122 Chemical Gene M|amod|START_ENTITY inhibited|nsubj|M inhibited|ccomp|displayed displayed|nmod|END_ENTITY 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 . 24962868 7 10-gingerol 1280,1291 STAT3 1346,1351 10-gingerol STAT3 MESH:C007845 6774 Chemical Gene 6-gingerol|conj|START_ENTITY analogues|nmod|6-gingerol found|advcl|analogues found|xcomp|blocker blocker|nmod|activation activation|compound|END_ENTITY Compared with other analogues of 6SG , such as 6-gingerol -LRB- 6G -RRB- , 8-gingerol -LRB- 8G -RRB- , and 10-gingerol -LRB- 10G -RRB- , 6SG was found to be the most potent blocker of STAT3 activation . 26554741 0 10-Gingerol 0,11 Akt 105,108 10-Gingerol Akt MESH:C007845 207 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|nmod|suppression suppression|nmod|END_ENTITY 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast_cancer cells through suppression of Akt and p38MAPK activity . 21846463 0 10-Gingerol 0,11 ghrelin 100,107 10-Gingerol ghrelin MESH:C007845 59301(Tax:10116) Chemical Gene improves|nsubj|START_ENTITY improves|advcl|inhibiting inhibiting|dobj|degradation degradation|compound|END_ENTITY 10-Gingerol , a component of rikkunshito , improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation . 12010066 1 10H 644,647 scFv 631,635 10H scFv null 652070 Chemical Gene tri|dobj|START_ENTITY tri|nsubj|+ +|compound|END_ENTITY Arrhenius activation parameters -LRB- E -LRB- a -RRB- and A -RRB- are reported for the loss of 1 and a series of monodeoxy_trisaccharide congeners -LRB- 5-8 identical with tri -RRB- from the -LRB- scFv + tri + 10H -RRB- -LRB- +10 -RRB- complex . 12010066 2 10H 768,771 scFv 757,761 10H scFv null 652070 Chemical Gene +|dep|START_ENTITY +|dep|+ +|compound|END_ENTITY The energetic contribution of the specific oligosaccharide OH groups to the stability of the -LRB- scFv + 1 + 10H -RRB- -LRB- +10 -RRB- complex is determined from the differences in E -LRB- a -RRB- measured for the trisaccharide analogues and 1 -LRB- 55.2 kcal/mol -RRB- . 28740028 9 10H2DA 1109,1115 adiponectin 1151,1162 10H2DA adiponectin null 11450(Tax:10090) Chemical Gene enhanced|nsubj|START_ENTITY enhanced|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY Furthermore , 10H2DA neither enhanced the expression of adiponectin receptor mRNA nor activated the insulin signaling cascade , such as GSK-3b phosphorylation , in the liver . 21850473 10 10H2DA 1409,1415 CTGF 1351,1355 10H2DA CTGF null 1490 Chemical Gene down-regulate|nsubj|START_ENTITY suggest|conj|down-regulate suggest|ccomp|factor factor|nsubj|END_ENTITY These results suggest that CTGF is a regulator factor in the expression of MMPs , and 10H2DA down-regulate the concentration of MMPs probably by down-regulating the expression of CTGF . 21850473 10 10H2DA 1409,1415 CTGF 1502,1506 10H2DA CTGF null 1490 Chemical Gene down-regulate|nsubj|START_ENTITY down-regulate|advcl|down-regulating down-regulating|dobj|expression expression|nmod|END_ENTITY These results suggest that CTGF is a regulator factor in the expression of MMPs , and 10H2DA down-regulate the concentration of MMPs probably by down-regulating the expression of CTGF . 21850473 8 10H2DA 1261,1267 CTGF 1162,1166 10H2DA CTGF null 1490 Chemical Gene treatment|nummod|START_ENTITY down-regulated|nmod|treatment down-regulated|nsubjpass|END_ENTITY CTGF , a member of the C-terminal cystein-rich proteins -LRB- CCN -RRB- family , was down-regulated after 24-h 10H2DA treatment . 21948282 7 10H2DA 962,968 G-CSF 902,907 10H2DA G-CSF null 12985(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|appos|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 23754629 5 10H2DA 680,686 glucose_transporter_4 814,835 10H2DA glucose transporter 4 null 20528(Tax:10090) Chemical Gene activates|nsubj|START_ENTITY activates|conj|increased increased|nmod|myotubes myotubes|nmod|translocation translocation|nmod|Glut4 Glut4|amod|END_ENTITY 10H2DA activates AMPK independently of insulin and significantly increased glucose uptake into L6 myotubes following translocation of glucose_transporter_4 -LRB- Glut4 -RRB- to the plasma membrane -LRB- PM -RRB- . 23754629 5 10H2DA 680,686 Glut4 837,842 10H2DA Glut4 null 20528(Tax:10090) Chemical Gene activates|nsubj|START_ENTITY activates|conj|increased increased|nmod|myotubes myotubes|nmod|translocation translocation|nmod|END_ENTITY 10H2DA activates AMPK independently of insulin and significantly increased glucose uptake into L6 myotubes following translocation of glucose_transporter_4 -LRB- Glut4 -RRB- to the plasma membrane -LRB- PM -RRB- . 23754629 7 10H2DA 1073,1079 Glut4 1133,1138 10H2DA Glut4 null 20528(Tax:10090) Chemical Gene administration|nmod|START_ENTITY stimulated|nsubj|administration stimulated|dobj|phosphorylation phosphorylation|conj|translocation translocation|amod|END_ENTITY Oral administration of 10H2DA significantly stimulated phosphorylation of AMPK and Glut4 translocation to the PM in mouse skeletal muscle . 28740028 8 10H2DA 925,931 GLUT4 1075,1080 10H2DA GLUT4 null 20528(Tax:10090) Chemical Gene increased|nsubj|START_ENTITY increased|parataxis|correlate correlate|nmod|translocation translocation|compound|END_ENTITY 10H2DA increased the expression of phosphorylated AMPK -LRB- pAMPK -RRB- protein in skeletal muscles ; however , this expression did not correlate with increased GLUT4 translocation . 21948282 7 10H2DA 962,968 granulocyte_colony-stimulating_factor 863,900 10H2DA granulocyte colony-stimulating factor null 12985(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|conj|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 28740028 9 10H2DA 1109,1115 GSK-3b 1230,1236 10H2DA GSK-3b null 56637(Tax:10090) Chemical Gene enhanced|nsubj|START_ENTITY enhanced|conj|activated activated|xcomp|signaling signaling|dobj|cascade cascade|nmod|phosphorylation phosphorylation|compound|END_ENTITY Furthermore , 10H2DA neither enhanced the expression of adiponectin receptor mRNA nor activated the insulin signaling cascade , such as GSK-3b phosphorylation , in the liver . 21948282 4 10H2DA 660,666 IFN-b 625,630 10H2DA IFN-b null 15977(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|acl|induced induced|nmod|over-expression over-expression|nmod|MyD88 MyD88|conj|END_ENTITY In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA . 21948282 7 10H2DA 962,968 IFN-b 1035,1040 10H2DA IFN-b null 15977(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 5 10H2DA 747,753 IkB 712,715 10H2DA IkB null 18036(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Degradation Degradation|conj|phosphorylation phosphorylation|nmod|kinase-a kinase-a|compound|END_ENTITY Degradation of IkB-a and phosphorylation of IkB kinase-a were not inhibited by 10H2DA . 21948282 7 10H2DA 962,968 IkB 932,935 10H2DA IkB null 18036(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|acl:relcl|dependent dependent|nmod|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 7 10H2DA 962,968 IkB 986,989 10H2DA IkB null 18036(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 8 10H2DA 1157,1163 IkB 1199,1202 10H2DA IkB null 18036(Tax:10090) Chemical Gene specifically|nmod:npmod|START_ENTITY inhibited|advmod|specifically inhibited|nsubj|END_ENTITY Together , 10H2DA specifically inhibited LPS-induced IkB - expression , followed by inhibition of IkB - - dependent gene production . 21948282 8 10H2DA 1157,1163 IkB 1244,1247 10H2DA IkB null 18036(Tax:10090) Chemical Gene specifically|nmod:npmod|START_ENTITY inhibited|advmod|specifically inhibited|nsubj|IkB IkB|dep|expression expression|acl|followed followed|nmod|inhibition inhibition|nmod|END_ENTITY Together , 10H2DA specifically inhibited LPS-induced IkB - expression , followed by inhibition of IkB - - dependent gene production . 21948282 9 10H2DA 1305,1311 IkB 1485,1488 10H2DA IkB null 18036(Tax:10090) Chemical Gene one|nsubj|START_ENTITY suggest|ccomp|one suggest|conj|candidate candidate|nmod|inflammatory inflammatory|acl|associated associated|nmod|production production|amod|END_ENTITY These results suggest that 10H2DA is one of the components of royal jelly to show anti-inflammatory effects and could be a therapeutic drug candidate for inflammatory and autoimmune_diseases associated with IkB - and IL-6 production . 21948282 2 10H2DA 317,323 IL-6 346,350 10H2DA IL-6 null 16193(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|dose-dependently dose-dependently|compound|END_ENTITY 10H2DA inhibited LPS-induced IL-6 production dose-dependently , but did not inhibit TNF-a production . 21948282 9 10H2DA 1305,1311 IL-6 1496,1500 10H2DA IL-6 null 16193(Tax:10090) Chemical Gene one|nsubj|START_ENTITY suggest|ccomp|one suggest|conj|candidate candidate|nmod|inflammatory inflammatory|acl|associated associated|nmod|production production|amod|IkB IkB|conj|END_ENTITY These results suggest that 10H2DA is one of the components of royal jelly to show anti-inflammatory effects and could be a therapeutic drug candidate for inflammatory and autoimmune_diseases associated with IkB - and IL-6 production . 23079939 4 10H2DA 614,620 inducible_NO_synthase 548,569 10H2DA inducible NO synthase null 551143(Tax:7460) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|conj|END_ENTITY LPS-induced NO production and inducible_NO_synthase -LRB- iNOS -RRB- gene transcription were inhibited by 10H2DA . 23079939 4 10H2DA 614,620 iNOS 571,575 10H2DA iNOS null 551143(Tax:7460) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|dep|END_ENTITY LPS-induced NO production and inducible_NO_synthase -LRB- iNOS -RRB- gene transcription were inhibited by 10H2DA . 23079939 5 10H2DA 808,814 iNOS 773,777 10H2DA iNOS null 551143(Tax:7460) Chemical Gene unaffected|nmod|START_ENTITY unaffected|nsubj|production production|acl:relcl|required required|nmod|induction induction|amod|END_ENTITY LPS-stimulated interferon -LRB- IFN -RRB- - b production , IFN regulatory factor-1 induction and IFN-stimulated response element activation , which are required for iNOS induction , were unaffected by 10H2DA . 21948282 7 10H2DA 962,968 lipocalin-2 847,858 10H2DA lipocalin-2 null 16819(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 7 10H2DA 962,968 MIP-2 1131,1136 10H2DA MIP-2 null 20310(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|IFN-b IFN-b|appos|-1 -1|amod|a a|conj|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 7 10H2DA 962,968 monocyte_chemotactic_protein-1 1049,1079 10H2DA monocyte chemotactic protein-1 null 20296(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|IFN-b IFN-b|appos|-1 -1|amod|END_ENTITY Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not . 21948282 4 10H2DA 660,666 MyD88 560,565 10H2DA MyD88 null 17874(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|acl|induced induced|nmod|over-expression over-expression|nmod|END_ENTITY In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA . 28740028 11 10H2DA 1525,1531 Pgc-1a 1618,1624 10H2DA Pgc-1a null 19017(Tax:10090) Chemical Gene involved|nsubjpass|START_ENTITY involved|nmod|part part|nmod|activation activation|nmod|expression expression|compound|END_ENTITY These findings suggest that 10H2DA is involved in the improvement of type 2 diabetes , at least in part via activation of Pgc-1a expression , but does not prevent obesity . 21948282 2 10H2DA 317,323 TNF-a 400,405 10H2DA TNF-a null 21926(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|conj|inhibit inhibit|dobj|production production|amod|END_ENTITY 10H2DA inhibited LPS-induced IL-6 production dose-dependently , but did not inhibit TNF-a production . 21948282 4 10H2DA 660,666 TRIF 632,636 10H2DA TRIF null 106759(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|appos|END_ENTITY In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA . 27847405 4 10-H2DA 628,635 interleukin-10 770,784 10-H2DA interleukin-10 null 3586 Chemical Gene had|nsubj|START_ENTITY had|dobj|effects effects|amod|nitric_oxide nitric_oxide|conj|END_ENTITY The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production . 27847405 4 10-H2DA 628,635 TNF-a 809,814 10-H2DA TNF-a null 7124 Chemical Gene had|nsubj|START_ENTITY showed|ccomp|had showed|conj|decreased decreased|dobj|production production|amod|END_ENTITY The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production . 24520713 0 10H2O 73,78 Cd2 11,14 10H2O Cd2 null 914 Chemical Gene x|nummod|START_ENTITY FS|dep|x salt|dep|FS water|nmod|salt +|nmod|water +|compound|END_ENTITY Removal of Cd2 + from water by Friedel 's salt -LRB- FS : 3CaO x A12O3 x CaCI2 x 10H2O -RRB- : sorption characteristics and mechanisms . 11969424 10 10-HCO-DHF 1484,1494 cytochrome_c 1444,1456 10-HCO-DHF cytochrome c null 54205 Chemical Gene oxidation|nmod|START_ENTITY oxidation|amod|END_ENTITY To our knowledge , this cytochrome_c oxidation of 10-HCO-THF to 10-HCO-DHF in the mitochondrial intermembrane space represents a possible folate metabolic pathway previously unidentified and would explain the bioactivity of unnatural carbon-6 isomers , -LRB- 6R -RRB- -5 - HCO-THF_and _ -LRB- 6S -RRB- -5,10 - CH-THF , in humans . 11969424 8 10-HCO-DHF 1200,1210 cytochrome_c 1163,1175 10-HCO-DHF cytochrome c null 54205 Chemical Gene identified|parataxis|START_ENTITY identified|nmod|IV IV|acl:relcl|contains contains|xcomp|END_ENTITY The site of electron donation was identified as complex IV , which contains cytochrome_c ; the folate product was 10-HCO-DHF , and the reaction was saturable with respect to 10-HCO-THF . 8948466 7 10-HCO-H2folate 398,413 C-6 558,561 10-HCO-H2folate C-6 null 729 Chemical Gene spectroscopy|nmod|START_ENTITY suggested|nsubj|spectroscopy suggested|conj|proposed proposed|nsubj|evidence evidence|nmod|proton proton|compound|END_ENTITY 1H-NMR spectroscopy of 10-HCO-H2folate -LRB- in 2H2O ; 300 MHz -RRB- suggested a pure compound and gave resonances for one formyl group proton , two protons on C-7_and_C-9 , and no evidence for a C-6 proton , which is consistent with the structure proposed . 8948466 7 10-HCO-H2folate 398,413 C-7_and_C-9 523,534 10-HCO-H2folate C-7 and C-9 null 730;735 Chemical Gene spectroscopy|nmod|START_ENTITY suggested|nsubj|spectroscopy suggested|conj|gave gave|dobj|protons protons|nmod|END_ENTITY 1H-NMR spectroscopy of 10-HCO-H2folate -LRB- in 2H2O ; 300 MHz -RRB- suggested a pure compound and gave resonances for one formyl group proton , two protons on C-7_and_C-9 , and no evidence for a C-6 proton , which is consistent with the structure proposed . 7646059 1 10-HCO-H4PteGlu 220,235 10-Formyltetrahydrofolate_dehydrogenase 83,122 10-HCO-H4PteGlu 10-Formyltetrahydrofolate dehydrogenase null 64392(Tax:10116) Chemical Gene 10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate . 7646059 1 10-HCO-H4PteGlu 327,342 10-Formyltetrahydrofolate_dehydrogenase 83,122 10-HCO-H4PteGlu 10-Formyltetrahydrofolate dehydrogenase null 64392(Tax:10116) Chemical Gene cleavage|nmod|START_ENTITY NADP|dep|cleavage H4PteGlu|conj|NADP tetrahydrofolate|dobj|H4PteGlu 10-formyltetrahydrofolate|acl|tetrahydrofolate oxidation|nmod|10-formyltetrahydrofolate NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY 10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate . 7646059 10 10-HCO-H4PteGlu 1643,1658 10-FTHFDH 1536,1545 10-HCO-H4PteGlu 10-FTHFDH null 64392(Tax:10116) Chemical Gene site|amod|START_ENTITY shows|dobj|site shows|nsubj|domain domain|nmod|END_ENTITY The N-terminal domain of 10-FTHFDH shows identity to glycinamide_ribonucleotide transformylase -LRB- EC 2.1.2.2 -RRB- and contains a putative 10-HCO-H4PteGlu binding site but shows no GAR-TF activity . 7646059 11 10-HCO-H4PteGlu 1733,1748 10-FTHFDH 1752,1761 10-HCO-H4PteGlu 10-FTHFDH null 64392(Tax:10116) Chemical Gene START_ENTITY|nmod|END_ENTITY NADP -LRB- + -RRB- - dependent oxidation of 10-HCO-H4PteGlu by 10-FTHFDH was inhibited by the folate anti-metabolite , 5,10-dideazatetrahydrofolate , a known GAR-TF inhibitor . 11969424 10 10-HCO-THF 1470,1480 cytochrome_c 1444,1456 10-HCO-THF cytochrome c null 54205 Chemical Gene 10-HCO-DHF|nummod|START_ENTITY oxidation|nmod|10-HCO-DHF oxidation|amod|END_ENTITY To our knowledge , this cytochrome_c oxidation of 10-HCO-THF to 10-HCO-DHF in the mitochondrial intermembrane space represents a possible folate metabolic pathway previously unidentified and would explain the bioactivity of unnatural carbon-6 isomers , -LRB- 6R -RRB- -5 - HCO-THF_and _ -LRB- 6S -RRB- -5,10 - CH-THF , in humans . 11969424 8 10-HCO-THF 1259,1269 cytochrome_c 1163,1175 10-HCO-THF cytochrome c null 54205 Chemical Gene saturable|nmod|START_ENTITY 10-HCO-DHF|conj|saturable identified|parataxis|10-HCO-DHF identified|nmod|IV IV|acl:relcl|contains contains|xcomp|END_ENTITY The site of electron donation was identified as complex IV , which contains cytochrome_c ; the folate product was 10-HCO-DHF , and the reaction was saturable with respect to 10-HCO-THF . 26815184 1 10-HCPT 167,174 vascular_endothelial_growth_factor 197,231 10-HCPT vascular endothelial growth factor null 7422 Chemical Gene 10-Hydroxycamptotbecine|appos|START_ENTITY effect|nmod|10-Hydroxycamptotbecine study|dobj|effect study|nmod|expression expression|nmod|END_ENTITY OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- . 26815184 1 10-HCPT 167,174 VEGF 232,236 10-HCPT VEGF null 7422 Chemical Gene 10-Hydroxycamptotbecine|appos|START_ENTITY effect|nmod|10-Hydroxycamptotbecine study|dobj|effect study|nmod|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- . 26815184 4 10-HCPT 809,816 VEGF 896,900 10-HCPT VEGF null 7422 Chemical Gene groups|nummod|START_ENTITY dose|nmod:npmod|groups showed|advmod|dose showed|nmod|effect effect|acl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY RESULTS : Compared with control group , high and low dose 10-HCPT groups showed significant values on the effect of inhibiting the expression of VEGF in RASFs . 26815184 6 10-HCPT 1158,1165 VEGF 1224,1228 10-HCPT VEGF null 7422 Chemical Gene showed|nsubj|START_ENTITY showed|advcl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY CONCLUSION : Compared with MTX , 10-HCPT showed significant effect on inhibiting the expression of VEGF in RASFs . 27049436 4 10HDA 777,782 EC-SOD 922,928 10HDA EC-SOD null 6649 Chemical Gene 10-hydroxydecanoic_acid|dep|START_ENTITY constituents|amod|10-hydroxydecanoic_acid effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|END_ENTITY Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells . 23995057 5 10HDA 794,799 IL-6 872,876 10HDA IL-6 null 16193(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|conj|necrosis necrosis|dobj|production production|compound|factor-a factor-a|conj|END_ENTITY 10HDA inhibited LPS-induced NO production , but not tumor necrosis factor-a or IL-6 production . 23995057 11 10HDA 1444,1449 IRF-1 1505,1510 10HDA IRF-1 null 16362(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|advcl|inhibiting inhibiting|dobj|translation translation|compound|END_ENTITY These results suggest that 10HDA inhibited LPS-induced NO production through inhibiting IRF-1 translation . 23995057 8 10HDA 1203,1208 IRF-1 1162,1167 10HDA IRF-1 null 16362(Tax:10090) Chemical Gene affected|nmod|START_ENTITY affected|nsubjpass|increase increase|nmod|mRNA mRNA|compound|END_ENTITY The LPS-induced increase of IRF-1 mRNA , however , was not affected by 10HDA . 23995057 9 10HDA 1298,1303 IRF-1 1224,1229 10HDA IRF-1 null 16362(Tax:10090) Chemical Gene decreased|nmod|START_ENTITY decreased|nsubjpass|level level|compound|END_ENTITY We found that IRF-1 mRNA level in the polysomal fraction was significantly decreased by 10HDA . 23995057 7 10HDA 1127,1132 STAT1 1019,1024 10HDA STAT1 null 20846(Tax:10090) Chemical Gene reduced|nmod|START_ENTITY -1|ccomp|reduced affected|conj|-1 affected|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY Phosphorylation of STAT1 and STAT2 was not affected , but IFN-regulatory_factor _ -LRB- IRF -RRB- -1 production was significantly reduced by 10HDA . 23995057 7 10HDA 1127,1132 STAT2 1029,1034 10HDA STAT2 null 20847(Tax:10090) Chemical Gene reduced|nmod|START_ENTITY -1|ccomp|reduced affected|conj|-1 affected|nsubjpass|Phosphorylation Phosphorylation|nmod|STAT1 STAT1|conj|END_ENTITY Phosphorylation of STAT1 and STAT2 was not affected , but IFN-regulatory_factor _ -LRB- IRF -RRB- -1 production was significantly reduced by 10HDA . 27049436 4 10HDA 777,782 THP-1 932,937 10HDA THP-1 null 2736 Chemical Gene 10-hydroxydecanoic_acid|dep|START_ENTITY constituents|amod|10-hydroxydecanoic_acid effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|EC-SOD EC-SOD|nmod|cells cells|compound|END_ENTITY Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells . 25789174 7 10-HDA 1140,1146 daf-15 1204,1210 10-HDA daf-15 null 177770(Tax:6239) Chemical Gene extend|nsubj|START_ENTITY extend|nmod|END_ENTITY We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15 , which encodes Raptor , a target of rapamycin -LRB- TOR -RRB- components , indicating that 10-HDA shared some longevity control mechanisms with TOR signaling . 25789174 7 10-HDA 1290,1296 daf-15 1204,1210 10-HDA daf-15 null 177770(Tax:6239) Chemical Gene shared|nsubj|START_ENTITY indicating|ccomp|shared encodes|dep|indicating END_ENTITY|acl:relcl|encodes We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15 , which encodes Raptor , a target of rapamycin -LRB- TOR -RRB- components , indicating that 10-HDA shared some longevity control mechanisms with TOR signaling . 21858156 12 10-HDA 1620,1626 DAF-16 1719,1725 10-HDA DAF-16 null 172981(Tax:6239) Chemical Gene 10-Hydroxy-2-decenoic_acid|appos|START_ENTITY increased|nsubj|10-Hydroxy-2-decenoic_acid increased|nmod|activity activity|compound|END_ENTITY 10-Hydroxy-2-decenoic_acid -LRB- 10-HDA -RRB- , which was present at high concentrations in pRJ-Fr .5 , increased lifespan independently of DAF-16 activity . 25789174 4 10-HDA 669,675 daf-2 713,718 10-HDA daf-2 null 175410(Tax:6239) Chemical Gene extended|nsubj|START_ENTITY extended|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY 10-HDA further extended the lifespan of the daf-2 mutants , which exhibit long lifespan through reducing insulin-like_signaling -LRB- ILS -RRB- , indicating that 10-HDA extended lifespan independently of ILS . 25789174 4 10-HDA 819,825 daf-2 713,718 10-HDA daf-2 null 175410(Tax:6239) Chemical Gene lifespan|amod|START_ENTITY indicating|dobj|lifespan extended|advcl|indicating extended|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY 10-HDA further extended the lifespan of the daf-2 mutants , which exhibit long lifespan through reducing insulin-like_signaling -LRB- ILS -RRB- , indicating that 10-HDA extended lifespan independently of ILS . 25789174 5 10-HDA 885,891 eat-2 927,932 10-HDA eat-2 null 175072(Tax:6239) Chemical Gene extend|nsubj|START_ENTITY extend|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY On the other hand , 10-HDA did not extend the lifespan of the eat-2 mutants , which show long lifespan through dietary restriction caused by a food-intake defect . 28417225 6 10-HDA 1270,1276 electron_transfer_flavoprotein_subunit_beta 1154,1197 10-HDA electron transfer flavoprotein subunit beta null 410308(Tax:7460) Chemical Gene production|nummod|START_ENTITY decreased|dobj|production decreased|nsubj|knockdown knockdown|nmod|END_ENTITY And RNA interference -LRB- RNAi -RRB- results demonstrated that knockdown of electron_transfer_flavoprotein_subunit_beta -LRB- ETF-b -RRB- , one of the protein related to fatty_acid metabolism , decreased 10-HDA production of worker bees , suggesting that ETF-b was necessary for 10-HDA biosynthesis . 28417225 6 10-HDA 1344,1350 electron_transfer_flavoprotein_subunit_beta 1154,1197 10-HDA electron transfer flavoprotein subunit beta null 410308(Tax:7460) Chemical Gene biosynthesis|nummod|START_ENTITY necessary|nmod|biosynthesis suggesting|ccomp|necessary decreased|advcl|suggesting decreased|nsubj|knockdown knockdown|nmod|END_ENTITY And RNA interference -LRB- RNAi -RRB- results demonstrated that knockdown of electron_transfer_flavoprotein_subunit_beta -LRB- ETF-b -RRB- , one of the protein related to fatty_acid metabolism , decreased 10-HDA production of worker bees , suggesting that ETF-b was necessary for 10-HDA biosynthesis . 17630200 5 10-HDA 625,631 IL-2 694,698 10-HDA IL-2 MESH:C017552 116562(Tax:10116) Chemical Gene effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|nmod|production production|appos|END_ENTITY The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression . 17630200 5 10-HDA 625,631 IL-2 734,738 10-HDA IL-2 MESH:C017552 116562(Tax:10116) Chemical Gene effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|conj|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression . 17630200 5 10-HDA 625,631 interleukin-2 679,692 10-HDA interleukin-2 MESH:C017552 116562(Tax:10116) Chemical Gene effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|nmod|production production|compound|END_ENTITY The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression . 28793915 6 10-HDA 1012,1018 microphthalmia-associated_transcription_factor 1127,1173 10-HDA microphthalmia-associated transcription factor null 17342(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|conj|END_ENTITY Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells . 28793915 5 10-HDA 890,896 MITF 911,915 10-HDA MITF null 17342(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|compound|END_ENTITY RESULTS : The results showed that 10-HDA inhibited the MITF protein expression -LRB- IC50 0.86 mM -RRB- in B16F1 melanoma cells . 28793915 6 10-HDA 1012,1018 MITF 1175,1179 10-HDA MITF null 17342(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|appos|END_ENTITY Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells . 21812645 8 10-HDA 1117,1123 MMP-1 1198,1203 10-HDA MMP-1 null 4312 Chemical Gene RJ|conj|START_ENTITY treated|nmod|RJ fibroblasts|acl|treated increased|nsubj|fibroblasts increased|conj|changed changed|nsubjpass|level level|nmod|END_ENTITY The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-b1 productions , but the level of MMP-1 was not changed . 23030720 11 10-HDA 1436,1442 MMP-1 1484,1489 10-HDA MMP-1 null 4312 Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|END_ENTITY Moreover , 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels . 23030720 13 10-HDA 1710,1716 MMP-1 1762,1767 10-HDA MMP-1 null 4312 Chemical Gene prevent|nsubj|START_ENTITY provide|ccomp|prevent provide|conj|inhibit inhibit|dobj|expressions expressions|amod|END_ENTITY CONCLUSION : The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions . 23030720 11 10-HDA 1436,1442 MMP-3 1494,1499 10-HDA MMP-3 null 4314 Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|MMP-1 MMP-1|conj|END_ENTITY Moreover , 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels . 23030720 13 10-HDA 1710,1716 MMP-3 1772,1777 10-HDA MMP-3 null 4314 Chemical Gene prevent|nsubj|START_ENTITY provide|ccomp|prevent provide|conj|inhibit inhibit|dobj|expressions expressions|amod|MMP-1 MMP-1|conj|END_ENTITY CONCLUSION : The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions . 23030720 12 10-HDA 1563,1569 p38 1625,1628 10-HDA p38 null 1432 Chemical Gene Treatment|nmod|START_ENTITY reduced|nsubj|Treatment reduced|dobj|activation activation|nmod|JNK JNK|conj|pathways pathways|amod|END_ENTITY Treatment with 10-HDA also reduced the UVA-induced activation of the JNK and p38 MAPK pathways . 21812645 8 10-HDA 1117,1123 TGF-b1 1161,1167 10-HDA TGF-b1 null 7040 Chemical Gene RJ|conj|START_ENTITY treated|nmod|RJ fibroblasts|acl|treated increased|nsubj|fibroblasts increased|dobj|I I|conj|productions productions|compound|END_ENTITY The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-b1 productions , but the level of MMP-1 was not changed . 28793915 6 10-HDA 1012,1018 TRP-1 1108,1113 10-HDA TRP-1 null 22178(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|END_ENTITY Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells . 28793915 6 10-HDA 1012,1018 TRP-2 1116,1121 10-HDA TRP-2 null 104042(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|conj|END_ENTITY Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells . 28793915 6 10-HDA 1012,1018 tyrosinase-related_protein_1 1078,1106 10-HDA tyrosinase-related protein 1 null 22178(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|amod|END_ENTITY Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells . 27847405 4 10-HDAA 637,644 interleukin-10 770,784 10-HDAA interleukin-10 null 3586 Chemical Gene 10-H2DA|conj|START_ENTITY had|nsubj|10-H2DA had|dobj|effects effects|amod|nitric_oxide nitric_oxide|conj|END_ENTITY The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production . 27847405 4 10-HDAA 637,644 TNF-a 809,814 10-HDAA TNF-a null 7124 Chemical Gene 10-H2DA|conj|START_ENTITY had|nsubj|10-H2DA showed|ccomp|had showed|conj|decreased decreased|dobj|production production|amod|END_ENTITY The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production . 9435160 3 10-HETE 663,670 CYP1A2 412,418 10-HETE CYP1A2 MESH:C095133 1544 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 9435160 3 10-HETE 663,670 CYP1A2 589,595 10-HETE CYP1A2 MESH:C095133 1544 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nmod|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 9435160 3 10-HETE 663,670 CYP2C19 436,443 10-HETE CYP2C19 MESH:C095133 1557 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 9435160 3 10-HETE 663,670 CYP2C8 420,426 10-HETE CYP2C8 MESH:C095133 1558 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 9435160 3 10-HETE 663,670 CYP2C9 428,434 10-HETE CYP2C9 MESH:C095133 1559 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 9435160 3 10-HETE 663,670 CYP3A4 448,454 10-HETE CYP3A4 MESH:C095133 1576 Chemical Gene 13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC . 15301793 4 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine 700,750 PAF 762,765 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine PAF null 300795(Tax:10116) Chemical Gene START_ENTITY|dep|END_ENTITY We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha . 15301793 4 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine 700,750 PAF 816,819 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine PAF null 300795(Tax:10116) Chemical Gene A23187|amod|START_ENTITY A23187|nmod|END_ENTITY We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha . 15301793 4 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine 700,750 TNF-alpha 824,833 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine TNF-alpha null 24835(Tax:10116) Chemical Gene A23187|amod|START_ENTITY A23187|nmod|PAF PAF|conj|END_ENTITY We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha . 3775692 1 1-0-hexadecyl_Paf-acether 218,243 thrombin 138,146 1-0-hexadecyl Paf-acether thrombin null 100009146(Tax:9986) Chemical Gene Collagen|amod|START_ENTITY Collagen|appos|END_ENTITY Collagen -LRB- 10-40 micrograms kg-1 -RRB- , thrombin -LRB- 1-10 units kg-1 -RRB- , adenosine_diphosphate -LRB- ADP ; 3-300 micrograms kg-1 -RRB- , 1-0-hexadecyl_Paf-acether and 1-0-octadecyl_Paf-acether -LRB- 1-300 ng kg-1 -RRB- administered by bolus intravenous injection each caused dose-dependent thrombocytopoenia accompanied by marked hypotension in anaesthetized rabbits . 16175144 8 10-hydroxy 1078,1088 CYP2D6 1112,1118 10-hydroxy CYP2D6 null 1565 Chemical Gene metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY Nortriptyline is further metabolized to 10-hydroxy metabolites , mainly by CYP2D6 . 8867869 0 10-hydroxy 52,62 CYP2D6 95,101 10-hydroxy CYP2D6 null 1565 Chemical Gene metabolite|amod|START_ENTITY nortriptyline|conj|metabolite levels|nmod|nortriptyline levels|dep|relationship relationship|nmod|genotype genotype|compound|END_ENTITY Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite : relationship to the CYP2D6 genotype . 9797795 0 10-hydroxy 42,52 CYP2D6 97,103 10-hydroxy CYP2D6 null 1565 Chemical Gene metabolite|amod|START_ENTITY nortriptyline|conj|metabolite Pharmacokinetics|nmod|nortriptyline Pharmacokinetics|nmod|genotypes genotypes|compound|END_ENTITY Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes . 6850066 2 10-hydroxy 456,466 ml-1_and_300_pg_ml-1 427,447 10-hydroxy ml-1 and 300 pg ml-1 null 112744 Chemical Gene metabolite|amod|START_ENTITY END_ENTITY|nmod|metabolite The minimum detectable concentrations for ketotifen and its demethylated metabolites were 50 pg ml-1_and_300_pg_ml-1 for the 10-hydroxy metabolite . 11052802 5 10-hydroxy 808,818 serum_albumin 887,900 10-hydroxy serum albumin null 213 Chemical Gene 7-alkylsilyl|conj|START_ENTITY substitution|amod|7-alkylsilyl enhances|nsubj|substitution enhances|nmod|presence presence|nmod|END_ENTITY In addition , the dual 7-alkylsilyl and 10-hydroxy substitution in 14 enhances drug stability in the presence of human serum_albumin . 21850473 0 10-hydroxy-2-decenoic_acid 58,84 Connective_tissue_growth_factor 0,31 10-hydroxy-2-decenoic acid Connective tissue growth factor MESH:C055543 1490 Chemical Gene MMPs|amod|START_ENTITY related|nmod|MMPs regulator|acl|related END_ENTITY|appos|regulator Connective_tissue_growth_factor , a regulator related with 10-hydroxy-2-decenoic_acid down-regulate MMPs in rheumatoid_arthritis . 27664731 3 10-hydroxy-2-decenoic_acid 629,655 Royalisin 618,627 10-hydroxy-2-decenoic acid Royalisin MESH:C055543 406143(Tax:7460) Chemical Gene Proteins|appos|START_ENTITY Proteins|appos|END_ENTITY Antimicrobial activities of crude Royal Jelly , Royalisin , 10-hydroxy-2-decenoic_acid , Jelleines , Major Royal Jelly Proteins against different bacteria have been reported . 21858156 12 10-Hydroxy-2-decenoic_acid 1592,1618 DAF-16 1719,1725 10-Hydroxy-2-decenoic acid DAF-16 MESH:C055543 172981(Tax:6239) Chemical Gene increased|nsubj|START_ENTITY increased|nmod|activity activity|compound|END_ENTITY 10-Hydroxy-2-decenoic_acid -LRB- 10-HDA -RRB- , which was present at high concentrations in pRJ-Fr .5 , increased lifespan independently of DAF-16 activity . 14696921 3 10-hydroxyaconitine 657,676 MSn 522,525 10-hydroxyaconitine MSn CHEBI:2429 4478 Chemical Gene mesaconitine|conj|START_ENTITY acid_esters|acl|mesaconitine elucidated|xcomp|acid_esters elucidated|advcl|spectra spectra|compound|END_ENTITY Based on their MSn spectra , the structures of the five novel compounds were elucidated to be C3,C8-difatty _ acid_esters of mesaconitine , aconitine and 10-hydroxyaconitine . 26815184 0 10-hydroxycamptotbecine 11,34 VEGF 56,60 10-hydroxycamptotbecine VEGF null 7422 Chemical Gene START_ENTITY|nmod|expression expression|nmod|END_ENTITY -LSB- Effect of 10-hydroxycamptotbecine on the expression of VEGF in rheumatoid_arthritis synovial fibroblasts -RSB- . 26815184 1 10-Hydroxycamptotbecine 142,165 vascular_endothelial_growth_factor 197,231 10-Hydroxycamptotbecine vascular endothelial growth factor null 7422 Chemical Gene effect|nmod|START_ENTITY study|dobj|effect study|nmod|expression expression|nmod|END_ENTITY OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- . 26815184 1 10-Hydroxycamptotbecine 142,165 VEGF 232,236 10-Hydroxycamptotbecine VEGF null 7422 Chemical Gene effect|nmod|START_ENTITY study|dobj|effect study|nmod|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- . 27721159 0 10-hydroxycamptothecin 63,85 Akt 130,133 10-hydroxycamptothecin Akt MESH:C028098 207 Chemical Gene I|conj|START_ENTITY effect|nmod|I effect|acl|p38 p38|dobj|MAPK MAPK|conj|END_ENTITY Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways . 16084097 1 10-hydroxycamptothecin 157,179 cis-4 107,112 10-hydroxycamptothecin cis-4 MESH:C028098 54607(Tax:10090) Chemical Gene docosahexenoic_acid|conj|START_ENTITY END_ENTITY|dep|docosahexenoic_acid We have synthesized a conjugate of cis-4 ,7,10,13,16,19 - docosahexenoic_acid -LRB- DHA -RRB- and 10-hydroxycamptothecin -LRB- HCPT -RRB- , DHA-HCPT . 11052802 7 10-hydroxycamptothecin 1205,1227 CPT-11 1294,1300 10-hydroxycamptothecin CPT-11 MESH:C028098 963084(Tax:115711) Chemical Gene comparable|conj|START_ENTITY analogues|amod|comparable topotecan|nmod|analogues topotecan|conj|END_ENTITY In vitro cytotoxicity assays using multiple different cell lines derived from eight distinct tumor types indicate that 14 is of comparable potency to camptothecin and 10-hydroxycamptothecin , as well as the FDA-approved camptothecin analogues topotecan and CPT-11 . 8010056 0 10-hydroxycamptothecin 62,84 DNA_topoisomerase_I 86,105 10-hydroxycamptothecin DNA topoisomerase I MESH:C028098 21969(Tax:10090) Chemical Gene inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin , DNA_topoisomerase_I inhibitor , in murine ascites_hepatoma cells . 8239542 0 10-hydroxycamptothecin 41,63 DNA_topoisomerase_I 10,29 10-hydroxycamptothecin DNA topoisomerase I MESH:C028098 21969(Tax:10090) Chemical Gene Effect|amod|START_ENTITY Effect|nmod|END_ENTITY Effect of DNA_topoisomerase_I inhibitor , 10-hydroxycamptothecin , on the structure and function of nuclei and nuclear matrix in bladder_carcinoma MBT-2 cells . 8239542 1 10-hydroxycamptothecin 173,195 DNA_topoisomerase_I 206,225 10-hydroxycamptothecin DNA topoisomerase I MESH:C028098 21969(Tax:10090) Chemical Gene effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY The effects of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a DNA_topoisomerase_I inhibitor , on the structure of nuclei and nuclear matrix and new DNA replication was investigated in murine bladder_carcinoma MBT-2 cells . 27721159 0 10-hydroxycamptothecin 63,85 ERK 121,124 10-hydroxycamptothecin ERK MESH:C028098 5594 Chemical Gene I|conj|START_ENTITY effect|nmod|I effect|acl|p38 p38|dobj|MAPK MAPK|conj|END_ENTITY Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways . 20810290 1 10-hydroxycamptothecin 256,278 HIF-1a 318,324 10-hydroxycamptothecin HIF-1a MESH:C028098 100009579(Tax:9986) Chemical Gene administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|hypoxia-inducible_factor-1a hypoxia-inducible_factor-1a|dep|END_ENTITY PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model . 20810290 1 10-hydroxycamptothecin 256,278 HIF-1a 340,346 10-hydroxycamptothecin HIF-1a MESH:C028098 100009579(Tax:9986) Chemical Gene administration|nmod|START_ENTITY effect|nmod|administration evaluate|dobj|effect evaluate|nmod|expression expression|compound|END_ENTITY PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model . 20810290 0 10-hydroxycamptothecin 48,70 hypoxia-inducible_factor-1a 74,101 10-hydroxycamptothecin hypoxia-inducible factor-1a MESH:C028098 100009579(Tax:9986) Chemical Gene START_ENTITY|nmod|expression expression|amod|END_ENTITY Experimental evaluation of inhibitory effect of 10-hydroxycamptothecin on hypoxia-inducible_factor-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization . 20810290 1 10-hydroxycamptothecin 256,278 hypoxia-inducible_factor-1a 289,316 10-hydroxycamptothecin hypoxia-inducible factor-1a MESH:C028098 100009579(Tax:9986) Chemical Gene administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model . 22320884 6 10-hydroxycamptothecin 1144,1166 MARVELD1 1058,1066 10-hydroxycamptothecin MARVELD1 MESH:C028098 83742 Chemical Gene epirubicin|conj|START_ENTITY enhance|nmod|epirubicin enhance|nsubj|overexpression overexpression|compound|END_ENTITY MARVELD1 overexpression could enhance chemosensitivity of HCC cells to epirubicin and 10-hydroxycamptothecin . 10493945 12 10-hydroxycamptothecin 1892,1914 MDM2 1837,1841 10-hydroxycamptothecin MDM2 MESH:C028098 4193 Chemical Gene adriamycin|conj|START_ENTITY agents|amod|adriamycin observed|nsubj|agents observed|nmod|effects effects|nmod|inhibition inhibition|compound|END_ENTITY Moreover , in vivo synergistically therapeutic effects of MDM2 inhibition and DNA damaging agents adriamycin and 10-hydroxycamptothecin were observed . 13130078 7 10-hydroxycamptothecin 1255,1277 MDM2 1133,1137 10-hydroxycamptothecin MDM2 MESH:C028098 4193 Chemical Gene agents|amod|START_ENTITY effects|nmod|agents potentiated|dobj|effects apoptosis|conj|potentiated apoptosis|nsubj|proliferation proliferation|nummod|END_ENTITY In all three cell lines , MDM2 inhibition reduced cell proliferation , induced apoptosis , and potentiated the effects of the chemotherapeutic agents 10-hydroxycamptothecin and paclitaxel . 22132187 6 10-hydroxycamptothecin 979,1001 MG132 1148,1153 10-hydroxycamptothecin MG132 MESH:C028098 875581(Tax:243273) Chemical Gene topoisomerases|appos|START_ENTITY microtubules|conj|topoisomerases microtubules|conj|RNA RNA|conj|synthesis synthesis|appos|gliotoxin gliotoxin|dep|mitomycin_C mitomycin_C|compound|END_ENTITY Interestingly , these compounds were acting on distinct cellular targets , including microtubules -LRB- paclitaxel , podophyllotoxin , vinblastine -RRB- and topoisomerases -LRB- 10-hydroxycamptothecin , camptothecin , daunorubicin , doxorubicin , etoposide -RRB- as well as DNA , RNA and protein synthesis and turnover -LRB- anisomycin , aphidicholin , gliotoxin , MG132 , methotrexate , mitomycin_C -RRB- . 26744836 10 10-hydroxycamptothecin 1018,1040 OAT3 1154,1158 10-hydroxycamptothecin OAT3 MESH:C028098 9376 Chemical Gene CPT|amod|START_ENTITY inhibit|nsubj|CPT inhibit|dobj|activity activity|nmod|END_ENTITY Our data revealed that CPT , 10-hydroxycamptothecin -LRB- HCPT -RRB- , 10-methoxycamptothecin -LRB- MCPT -RRB- and 9-nitrocamptothecin -LRB- 9NC -RRB- significantly inhibit the uptake activity of OAT3 . 12518324 7 10-hydroxycamptothecin 1266,1288 p21 1225,1228 10-hydroxycamptothecin p21 MESH:C028098 644914 Chemical Gene agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|conj|induction induction|amod|END_ENTITY The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel . 14751837 6 10-hydroxycamptothecin 1184,1206 p21 1143,1146 10-hydroxycamptothecin p21 MESH:C028098 644914 Chemical Gene agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|conj|induction induction|amod|END_ENTITY The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel . 9499438 0 10-hydroxycamptothecin 149,171 p21WAF1/CIP1 16,28 10-hydroxycamptothecin p21WAF1/CIP1 MESH:C028098 1026 Chemical Gene drugs|amod|START_ENTITY induced|nmod|drugs induced|nsubj|Upregulation Upregulation|nmod|END_ENTITY Upregulation of p21WAF1/CIP1 in human breast_cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways . 27721159 0 10-hydroxycamptothecin 63,85 p38 111,114 10-hydroxycamptothecin p38 MESH:C028098 1432 Chemical Gene I|conj|START_ENTITY effect|nmod|I effect|acl|END_ENTITY Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways . 12518324 7 10-hydroxycamptothecin 1266,1288 p53 1206,1209 10-hydroxycamptothecin p53 MESH:C028098 7157 Chemical Gene agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|compound|END_ENTITY The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel . 14751837 6 10-hydroxycamptothecin 1184,1206 p53 1124,1127 10-hydroxycamptothecin p53 MESH:C028098 7157 Chemical Gene agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|compound|END_ENTITY The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel . 25523336 0 10-hydroxycamptothecin 106,128 RPL13A 0,6 10-hydroxycamptothecin RPL13A MESH:C028098 23521 Chemical Gene paclitaxel|conj|START_ENTITY treatments|amod|paclitaxel normalizing|nmod|treatments gene|acl|normalizing END_ENTITY|nmod|gene RPL13A as a reference gene for normalizing mRNA transcription of ovarian_cancer cells with paclitaxel and 10-hydroxycamptothecin treatments . 17482779 0 10-hydroxycamptothecin 73,95 serum_albumin 117,130 10-hydroxycamptothecin serum albumin MESH:C028098 24186(Tax:10116) Chemical Gene form|nmod|START_ENTITY Preparation|nmod|form Preparation|dep|END_ENTITY Preparation , characterization and biodistribution of the lactone form of 10-hydroxycamptothecin -LRB- HCPT -RRB- - loaded bovine serum_albumin -LRB- BSA -RRB- nanoparticles . 8355258 0 10-hydroxycamptothecin 62,84 serum_albumin 110,123 10-hydroxycamptothecin serum albumin MESH:C028098 213 Chemical Gene START_ENTITY|nmod|presence presence|nmod|END_ENTITY Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum_albumin . 11589502 1 10-hydroxycamptothecin 99,121 SRB 246,249 10-hydroxycamptothecin SRB MESH:C028098 10575 Chemical Gene potential|nmod|START_ENTITY investigate|dobj|potential detected|advcl|investigate detected|nmod|assay assay|compound|END_ENTITY To investigate the antiangiogenic potential of 10-hydroxycamptothecin -LRB- HCPT -RRB- , the proliferation of human microvascular endothelial cells -LRB- HMEC -RRB- and seven human tumor cell lines were detected by SRB assay , and the endothelial cell migration and tube formation were assessed using two in vitro model systems . 27470413 11 10-hydroxy_camptothecin 1694,1717 Ch-1 1606,1610 10-hydroxy camptothecin Ch-1 MESH:C028098 51430 Chemical Gene effect|nmod|START_ENTITY enhanced|dobj|effect enhanced|nsubj|END_ENTITY Amazingly , Ch-1 at non-toxic concentration -LRB- 2.5-10 M -RRB- enhanced significantly anti-cancer effect of 10-hydroxy_camptothecin -LRB- HCPT -RRB- on Hela , BGC823 , and MCF-7 cells . 23498119 1 10-hydroxy_camptothecin 185,208 serum_albumin 229,242 10-hydroxy camptothecin serum albumin MESH:C028098 213 Chemical Gene drug|dep|START_ENTITY graphene_oxide|conj|drug graphene_oxide|conj|END_ENTITY The interaction of graphene_oxide -LRB- GO -RRB- , a medicinal drug -LRB- 10-hydroxy_camptothecin -LRB- HCPT -RRB- -RRB- , and bovine serum_albumin -LRB- BSA -RRB- was investigated with the aim of developing a method for the analysis of serum_albumin proteins . 23498119 1 10-hydroxy_camptothecin 185,208 serum_albumin 322,335 10-hydroxy camptothecin serum albumin MESH:C028098 213 Chemical Gene drug|dep|START_ENTITY graphene_oxide|conj|drug interaction|nmod|graphene_oxide investigated|nsubjpass|interaction investigated|nmod|aim aim|acl|developing developing|nmod|analysis analysis|nmod|proteins proteins|compound|END_ENTITY The interaction of graphene_oxide -LRB- GO -RRB- , a medicinal drug -LRB- 10-hydroxy_camptothecin -LRB- HCPT -RRB- -RRB- , and bovine serum_albumin -LRB- BSA -RRB- was investigated with the aim of developing a method for the analysis of serum_albumin proteins . 26639236 0 10-Hydroxycamptothecin 0,22 caspase_3 110,119 10-Hydroxycamptothecin caspase 3 MESH:C028098 836 Chemical Gene induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|p53 p53|conj|END_ENTITY 10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways . 26639236 0 10-Hydroxycamptothecin 0,22 cytochrome_c 92,104 10-Hydroxycamptothecin cytochrome c MESH:C028098 54205 Chemical Gene induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|p53 p53|conj|END_ENTITY 10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways . 28097065 0 10-Hydroxycamptothecin 24,46 NOXA 16,20 10-Hydroxycamptothecin NOXA MESH:C028098 492821(Tax:10116) Chemical Gene END_ENTITY|nmod|START_ENTITY Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing_epidural_fibrosis . 26639236 0 10-Hydroxycamptothecin 0,22 p53 87,90 10-Hydroxycamptothecin p53 MESH:C028098 7157 Chemical Gene induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|END_ENTITY 10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways . 11270977 1 10-Hydroxycamptothecin 161,183 ST1435 210,216 10-Hydroxycamptothecin ST1435 MESH:C028098 1459466(Tax:273063) Chemical Gene START_ENTITY|conj|19-norprogesteron 19-norprogesteron|appos|END_ENTITY AIM : Genotoxicity evaluations of several different chemicals including L-4-oxalysine , 10-Hydroxycamptothecin -LRB- HCT -RRB- , 19-norprogesteron -LRB- ST1435 -RRB- , dimethyl_sulfoxide -LRB- Me2SO -RRB- , bleomycin -LRB- BLM -RRB- , and mitomycin_C -LRB- MMC -RRB- . 25505251 4 10-Hydroxy-cis-12-octadecenoic_acid 641,676 occludin 832,840 10-Hydroxy-cis-12-octadecenoic acid occludin null 18260(Tax:10090) Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|changes changes|nmod|expression expression|nmod|molecules molecules|conj|END_ENTITY 10-Hydroxy-cis-12-octadecenoic_acid -LRB- HYA -RRB- , a gut microbial metabolite of linoleic_acid , suppressed TNF-a and dextran sulfate sodium-induced changes in the expression of TJ-related molecules , occludin , zonula occludens-1 , and myosin light chain kinase . 25505251 4 10-Hydroxy-cis-12-octadecenoic_acid 641,676 TNF-a 740,745 10-Hydroxy-cis-12-octadecenoic acid TNF-a null 21926(Tax:10090) Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|changes changes|amod|END_ENTITY 10-Hydroxy-cis-12-octadecenoic_acid -LRB- HYA -RRB- , a gut microbial metabolite of linoleic_acid , suppressed TNF-a and dextran sulfate sodium-induced changes in the expression of TJ-related molecules , occludin , zonula occludens-1 , and myosin light chain kinase . 8588874 7 10-hydroxydecanoic_acid 1392,1415 CDPK 1431,1435 10-hydroxydecanoic acid CDPK CHEBI:17409 543102(Tax:4565) Chemical Gene 12-Hydroxystearic_acid|conj|START_ENTITY inhibit|dep|12-Hydroxystearic_acid inhibit|dobj|END_ENTITY 12-Hydroxystearic_acid and 10-hydroxydecanoic_acid do not inhibit CDPK , PKC or MLCK but are selective inhibitors of cAK -LRB- IC50 values 127 and 138 microM , respectively -RRB- , consistent with a simple model for amphiphile inhibition of cAK involving two polar groups separated by a non-polar region . 27049436 4 10-hydroxydecanoic_acid 752,775 EC-SOD 922,928 10-hydroxydecanoic acid EC-SOD CHEBI:17409 6649 Chemical Gene constituents|amod|START_ENTITY effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|END_ENTITY Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells . 23995057 0 10-hydroxydecanoic_acid 21,44 interferon_regulatory_factor-1 135,165 10-hydroxydecanoic acid interferon regulatory factor-1 CHEBI:17409 16362(Tax:10090) Chemical Gene production|amod|START_ENTITY effect|nmod|production effect|nmod|macrophages macrophages|amod|END_ENTITY Inhibitory effect of 10-hydroxydecanoic_acid on lipopolysaccharide-induced nitric_oxide production via translational downregulation of interferon_regulatory_factor-1 in RAW264 murine macrophages . 8588874 7 10-hydroxydecanoic_acid 1392,1415 MLCK 1444,1448 10-hydroxydecanoic acid MLCK CHEBI:17409 291926(Tax:10116) Chemical Gene 12-Hydroxystearic_acid|conj|START_ENTITY inhibit|dep|12-Hydroxystearic_acid inhibit|dobj|CDPK CDPK|conj|END_ENTITY 12-Hydroxystearic_acid and 10-hydroxydecanoic_acid do not inhibit CDPK , PKC or MLCK but are selective inhibitors of cAK -LRB- IC50 values 127 and 138 microM , respectively -RRB- , consistent with a simple model for amphiphile inhibition of cAK involving two polar groups separated by a non-polar region . 27049436 4 10-hydroxydecanoic_acid 752,775 THP-1 932,937 10-hydroxydecanoic acid THP-1 CHEBI:17409 2736 Chemical Gene constituents|amod|START_ENTITY effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|EC-SOD EC-SOD|nmod|cells cells|compound|END_ENTITY Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells . 17992728 13 10-hydroxyfenchol 1679,1696 min-1 1806,1811 10-hydroxyfenchol min-1 MESH:C052091 966 Chemical Gene hydroxyfenchol|conj|START_ENTITY _|amod|hydroxyfenchol formation|nmod|_ values|nmod|formation 0.06|nsubj|values showed|ccomp|0.06 showed|conj|2.94 2.94|conj|P450 P450|amod|END_ENTITY Kinetic analysis showed that the Km values for the formation of fenchone , 6-exo - _ hydroxyfenchol and 10-hydroxyfenchol in rats treated with phenobarbital were 0.06 , 0.03 and 0.03 mM , and Vmax values were 2.94 , 6.1 and 13.8 nmol min-1 nmol-1 P450 , respectively . 17992728 13 10-hydroxyfenchol 1679,1696 P450 1819,1823 10-hydroxyfenchol P450 MESH:C052091 1555 Chemical Gene hydroxyfenchol|conj|START_ENTITY _|amod|hydroxyfenchol formation|nmod|_ values|nmod|formation 0.06|nsubj|values showed|ccomp|0.06 showed|conj|2.94 2.94|conj|END_ENTITY Kinetic analysis showed that the Km values for the formation of fenchone , 6-exo - _ hydroxyfenchol and 10-hydroxyfenchol in rats treated with phenobarbital were 0.06 , 0.03 and 0.03 mM , and Vmax values were 2.94 , 6.1 and 13.8 nmol min-1 nmol-1 P450 , respectively . 17142962 3 10-hydroxyfenchone 362,380 P450 407,411 10-hydroxyfenchone P450 MESH:C052091 1555 Chemical Gene 6-exo-hydroxyfenchone|conj|START_ENTITY 6-exo-hydroxyfenchone|nmod|enzymes enzymes|compound|END_ENTITY -LRB- + -RRB- - Fenchone was found to be oxidized to 6-exo-hydroxyfenchone , 6-endo-hydroxyfenchone and 10-hydroxyfenchone by human liver microsomal P450 enzymes . 17484521 3 10-hydroxyfenchone 366,384 P450 411,415 10-hydroxyfenchone P450 MESH:C052091 1555 Chemical Gene 6-exo-hydroxyfenchone|conj|START_ENTITY 6-exo-hydroxyfenchone|nmod|enzymes enzymes|compound|END_ENTITY -LRB- - -RRB- - Fenchone was found to be oxidized to 6-exo-hydroxyfenchone , 6-endo-hydroxyfenchone and 10-hydroxyfenchone by human liver microsomal P450 enzymes . 18033743 6 10-hydroxygambogic_acid 733,756 GBA 827,830 10-hydroxygambogic acid GBA MESH:C550001 684536(Tax:10116) Chemical Gene acid|amod|START_ENTITY metabolites|appos|acid oxides|nsubj|metabolites oxides|nmod|bond bond|nmod|END_ENTITY Two phase I metabolites , 10-hydroxygambogic_acid and 9,10-epoxygambogic _ acid , were oxides on the 9,10-olefinic bond of GBA . 7726550 5 10-hydroxygeraniol 722,740 C-1_and_C-10 823,835 10-hydroxygeraniol C-1 and C-10 MESH:C471578 3183;3226 Chemical Gene that|amod|START_ENTITY oxidized|nsubjpass|that oxidized|nmod|END_ENTITY Gas chromatographic and coupled mass spectrometric analysis of the reaction products showed that 10-hydroxygeraniol and 10-hydroxynerol were oxidized by the enzyme in the presence of NADP + , at both C-1_and_C-10 . 20456828 4 10-hydroxyisorhynchophylline 646,674 MI2 584,587 10-hydroxyisorhynchophylline MI2 null 117535(Tax:10116) Chemical Gene plasma|conj|START_ENTITY plasma|conj|D-glucuronide D-glucuronide|appos|END_ENTITY RESULTS : ISOR was identified in plasma , 11-hydroxyisorhynchophylline_11-O -- D-glucuronide -LRB- MI1 -RRB- and 10-hydroxyisorhynchophylline_10-O -- D-glucuronide -LRB- MI2 -RRB- in bile , and free 11-hydroxyisorhynchophylline -LRB- MI3 -RRB- and 10-hydroxyisorhynchophylline -LRB- MI4 -RRB- in urine and feces . 10192963 1 10-hydroxyl 261,272 O-acetyltransferase 146,165 10-hydroxyl O-acetyltransferase null 64921 Chemical Gene group|amod|START_ENTITY possessing|dobj|group taxanes|acl|possessing range|nmod|taxanes acetylation|nmod|range catalyzes|dobj|acetylation END_ENTITY|acl:relcl|catalyzes An O-acetyltransferase that catalyzes the regiospecific acetylation of a range of taxanes possessing an unsubstituted 10-hydroxyl group was detected and purified to apparent electrophoretic homogeneity from a cytosolic fraction of Taxus chinensis cell cultures . 23169608 6 10-hydroxy-NBP 924,938 M3-1 917,921 10-hydroxy-NBP M3-1 null 10951 Chemical Gene M3-2|amod|START_ENTITY M2|conj|M3-2 M2|conj|END_ENTITY 10-Keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- , and M5-2 were the major circulating metabolites , wherein the areas under the curve values were 1.6 - , 2.9 - , 10.3 - , and 4.1-fold higher than that of NBP . 23434525 2 10-hydroxy-NBP 393,407 M3-1 386,390 10-hydroxy-NBP M3-1 null 10951 Chemical Gene 10-keto-NBP|conj|START_ENTITY 10-keto-NBP|conj|3-hydroxy-NBP 3-hydroxy-NBP|appos|END_ENTITY Our previous study showed that NBP underwent extensive metabolism in humans and that 10-keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- and NBP-11-oic_acid -LRB- M5-2 -RRB- were the major circulating metabolites . 15180333 13 10-hydroxynortriptyline 1601,1624 CYP2D6 1688,1694 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|conj|START_ENTITY profiles|amod|nortriptyline summarized|nmod|profiles summarized|nmod|number number|nmod|copies copies|compound|END_ENTITY The VizStruct visualization succinctly summarized the salient similarities and differences in the nortriptyline and 10-hydroxynortriptyline pharmacokinetic profiles in subjects with increasing number of CYP2D6 gene copies . 15180333 7 10-hydroxynortriptyline 923,946 CYP2D6 1009,1015 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene metabolite|amod|START_ENTITY nortriptyline|conj|metabolite kinetics|nmod|nortriptyline 63:444|nmod|kinetics subjects|nsubj|63:444 subjects|nmod|number number|nmod|copies copies|nmod|END_ENTITY 63:444 -452 , 1998 -RRB- on the kinetics of nortriptyline and its 10-hydroxynortriptyline metabolite in subjects with differing number of copies of the CYP2D6 , and the gene expression profiling data of Bohen and colleagues -LRB- Proc . 24257813 6 10-hydroxynortriptyline 1072,1095 CYP2D6 1004,1010 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|conj|START_ENTITY concentrations|amod|nortriptyline associated|nmod|concentrations associated|nsubjpass|genotype genotype|compound|END_ENTITY For those taking nortriptyline -LRB- n = 161 -RRB- , the CYP2D6 genotype was significantly associated with nortriptyline and 10-hydroxynortriptyline serum concentrations and 10-hydroxynortriptyline : nortrip-tyline ratio . 24257813 6 10-hydroxynortriptyline 1121,1144 CYP2D6 1004,1010 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene concentrations|conj|START_ENTITY associated|nmod|concentrations associated|nsubjpass|genotype genotype|compound|END_ENTITY For those taking nortriptyline -LRB- n = 161 -RRB- , the CYP2D6 genotype was significantly associated with nortriptyline and 10-hydroxynortriptyline serum concentrations and 10-hydroxynortriptyline : nortrip-tyline ratio . 28133768 0 10-hydroxynortriptyline 76,99 CYP2D6 14,20 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene levels|amod|START_ENTITY patients|nmod|levels paroxetine|nmod|patients dose|amod|paroxetine END_ENTITY|nmod|dose Inhibition of CYP2D6 with low dose -LRB- 5 mg -RRB- paroxetine in patients with high 10-hydroxynortriptyline serum levels - a review of routine practice . 8867869 1 10-hydroxynortriptyline 242,265 CYP2D6 141,147 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|conj|START_ENTITY levels|nmod|nortriptyline relationship|conj|levels relationship|nmod|genotype genotype|compound|END_ENTITY The relationship between the CYP2D6 genotype and the steady state plasma levels of nortriptyline -LRB- NT -RRB- , its main active metabolite 10-hydroxynortriptyline -LRB- 10-OH-NT -RRB- and the NT/10-OH-NT ratio were studied in 21 Caucasian depressed patients treated with 100-150 mg NT daily . 9585799 8 10-hydroxynortriptyline 2234,2257 CYP2D6 2111,2117 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|conj|START_ENTITY pharmacokinetics|nmod|nortriptyline show|nmod|pharmacokinetics show|dobj|importance importance|nmod|genotype genotype|compound|END_ENTITY CONCLUSION : The results of this study show the quantitative importance of the CYP2D6 genotype , especially the presence of multiple functional CYP2D6 genes for the pharmacokinetics of nortriptyline and 10-hydroxynortriptyline . 9585799 8 10-hydroxynortriptyline 2234,2257 CYP2D6 2175,2181 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|conj|START_ENTITY pharmacokinetics|nmod|nortriptyline show|nmod|pharmacokinetics show|dobj|importance importance|dep|presence presence|nmod|genes genes|compound|END_ENTITY CONCLUSION : The results of this study show the quantitative importance of the CYP2D6 genotype , especially the presence of multiple functional CYP2D6 genes for the pharmacokinetics of nortriptyline and 10-hydroxynortriptyline . 9797795 6 10-hydroxynortriptyline 1136,1159 CYP2D6 1251,1257 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene lower|advcl|START_ENTITY lower|conj|was was|advmod|longer longer|nmod|subjects subjects|acl:relcl|homozygous homozygous|nmod|END_ENTITY For 10-hydroxynortriptyline , the AUC was lower and the plasma half-life was longer in subjects who were homozygous for CYP2D6 * 10 than in subjects in the other 2 groups . 9797795 7 10-hydroxynortriptyline 1514,1537 CYP2D6 1317,1323 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele CYP2D6|acl|* associated|advcl|CYP2D6 CONCLUSION|dep|associated CONCLUSION|dep|END_ENTITY CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype . 9797795 7 10-hydroxynortriptyline 1514,1537 CYP2D6 1444,1450 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele END_ENTITY|acl|* CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype . 9797795 7 10-hydroxynortriptyline 1514,1537 CYP2D6 1577,1583 10-hydroxynortriptyline CYP2D6 MESH:C013567 1565 Chemical Gene nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele *|advmod|particularly particularly|nmod|subjects subjects|nmod|END_ENTITY CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype . 7105623 8 10-hydroxynortriptyline 1342,1365 min-1 1387,1392 10-hydroxynortriptyline min-1 MESH:C013567 966 Chemical Gene clearance|nmod|START_ENTITY /|nsubj|clearance /|parataxis|removed removed|nsubjpass|8 8|amod|END_ENTITY Dialysis clearance of conjugated 10-hydroxynortriptyline was 58 + / - 8 -LRB- SD -RRB- ml min-1 , but nortriptyline and unconjugated 10-hydroxynortriptyline were not appreciably removed by dialysis . 7105623 8 10-hydroxynortriptyline 1429,1452 min-1 1387,1392 10-hydroxynortriptyline min-1 MESH:C013567 966 Chemical Gene END_ENTITY|conj|START_ENTITY Dialysis clearance of conjugated 10-hydroxynortriptyline was 58 + / - 8 -LRB- SD -RRB- ml min-1 , but nortriptyline and unconjugated 10-hydroxynortriptyline were not appreciably removed by dialysis . 25505251 10 10-hydroxyoctadacanoic_acid 1491,1518 GPR40 1688,1693 10-hydroxyoctadacanoic acid GPR40 null 2864 Chemical Gene show|nsubj|START_ENTITY show|dobj|activities activities|conj|expression expression|compound|END_ENTITY Conversely , 10-hydroxyoctadacanoic_acid , which is a gut microbial metabolite of oleic_acid and lacks a carbon-carbon double bond at 12 position , did not show these TJ-restoring activities and down-regulated GPR40 expression . 26711482 3 10-hydroxyoxcarbazepine 758,781 CYP1A2 579,585 10-hydroxyoxcarbazepine CYP1A2 null 1544 Chemical Gene induce|nsubj|START_ENTITY determined|advcl|induce determined|nmod|END_ENTITY For the CYP1A2 the induction potential determined as the fold change in mRNA levels was 7.2 -LRB- range : 2.3-11 .5 -RRB- and 10.0 -LRB- 6.2-13 .7 -RRB- for oxcarbazepine and carbamazepine , respectively , while 10-hydroxyoxcarbazepine did not induce . 26711482 2 10-hydroxyoxcarbazepine 384,407 CYP2B6 471,477 10-hydroxyoxcarbazepine CYP2B6 null 1555 Chemical Gene metabolite|amod|START_ENTITY oxcarbazepine|appos|metabolite potentials|nmod|oxcarbazepine evaluated|nsubjpass|potentials evaluated|nmod|_ _|dep|levels levels|amod|_ _|dep|1A2 1A2|nummod|END_ENTITY Auto-induction potentials of oxcarbazepine , its pharmacologically active metabolite 10-hydroxyoxcarbazepine and carbamazepine were evaluated by cytochrome_P450 _ -LRB- CYP -RRB- _ 1A2 , CYP2B6 and CYP3A4 mRNA levels and primary metabolic rates using human hepatocytes and HepaRG cells . 26711482 4 10-hydroxyoxcarbazepine 915,938 CYP2B6 833,839 10-hydroxyoxcarbazepine CYP2B6 null 1555 Chemical Gene 11.5|amod|START_ENTITY 11.5|nsubj|change change|nmod|levels levels|nmod|END_ENTITY The fold change in mRNA levels for CYP2B6 was 11.5 -LRB- 3.2-19 .3 -RRB- , 7.0 -LRB- 2.5-10 .8 -RRB- and 14.8 -LRB- 3.1-29 .1 -RRB- for oxcarbazepine , 10-hydroxyoxcarbazepine and carbamazepine , respectively . 26711482 2 10-hydroxyoxcarbazepine 384,407 CYP3A4 482,488 10-hydroxyoxcarbazepine CYP3A4 null 1576 Chemical Gene metabolite|amod|START_ENTITY oxcarbazepine|appos|metabolite potentials|nmod|oxcarbazepine evaluated|nsubjpass|potentials evaluated|nmod|_ _|dep|levels levels|amod|_ _|dep|1A2 1A2|conj|END_ENTITY Auto-induction potentials of oxcarbazepine , its pharmacologically active metabolite 10-hydroxyoxcarbazepine and carbamazepine were evaluated by cytochrome_P450 _ -LRB- CYP -RRB- _ 1A2 , CYP2B6 and CYP3A4 mRNA levels and primary metabolic rates using human hepatocytes and HepaRG cells . 26711482 5 10-hydroxyoxcarbazepine 1033,1056 CYP3A4 992,998 10-hydroxyoxcarbazepine CYP3A4 null 1576 Chemical Gene oxcarbazepine|conj|START_ENTITY level|acl|oxcarbazepine level|dep|change change|nmod|END_ENTITY The fold change for CYP3A4 induction level by oxcarbazepine , 10-hydroxyoxcarbazepine and carbamazepine was 3.5 -LRB- 1.2-7 .4 -RRB- , 2.7 -LRB- 0.8-5 .7 -RRB- and 8.3 -LRB- 3.5-14 .5 -RRB- , respectively . 26711482 0 10-hydroxyoxcarbazepine 79,102 P450 25,29 10-hydroxyoxcarbazepine P450 null 1555 Chemical Gene drug|amod|START_ENTITY inductions|nmod|drug inductions|nsubj|Evaluation Evaluation|nmod|END_ENTITY Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine , 10-hydroxyoxcarbazepine , and carbamazepine using human hepatocytes and HepaRG cells . 16501007 11 10-hydroxyrutaecarpine 1352,1374 CYP1A1 1385,1391 10-hydroxyrutaecarpine CYP1A1 null 1543 Chemical Gene decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation . 16501007 11 10-hydroxyrutaecarpine 1352,1374 CYP1A2 1393,1399 10-hydroxyrutaecarpine CYP1A2 null 1544 Chemical Gene decreased|nsubj|START_ENTITY decreased|dobj|CYP1A1 CYP1A1|conj|END_ENTITY The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation . 16501007 11 10-hydroxyrutaecarpine 1352,1374 CYP1B1 1405,1411 10-hydroxyrutaecarpine CYP1B1 null 1545 Chemical Gene decreased|nsubj|START_ENTITY decreased|dobj|CYP1A1 CYP1A1|conj|activities activities|nummod|END_ENTITY The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation . 24958911 6 10-hydroxystearamide 856,876 EPHX1 839,844 10-hydroxystearamide EPHX1 MESH:C052091 2052 Chemical Gene inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY A selective EPHX1 inhibitor , 10-hydroxystearamide , inhibited 2-AG metabolism and hydrolysis of a well-known EPHX1 substrate , cis-stilbene_oxide . 24958911 6 10-hydroxystearamide 856,876 EPHX1 935,940 10-hydroxystearamide EPHX1 MESH:C052091 2052 Chemical Gene inhibitor|amod|START_ENTITY inhibited|nsubj|inhibitor inhibited|dobj|metabolism metabolism|conj|hydrolysis hydrolysis|nmod|substrate substrate|compound|END_ENTITY A selective EPHX1 inhibitor , 10-hydroxystearamide , inhibited 2-AG metabolism and hydrolysis of a well-known EPHX1 substrate , cis-stilbene_oxide . 16348853 5 10-hydroxystearic_acid 512,534 B-3266 744,750 10-hydroxystearic acid B-3266 MESH:C070376 947768(Tax:511145) Chemical Gene hydrations|acl|START_ENTITY stereochemistries|nmod|hydrations stereochemistries|dep|ATCC ATCC|conj|END_ENTITY This report describes the stereochemistries of microbial hydrations of oleic_acid to 10-hydroxystearic_acid by Nocardia_aurantia -LRB- also known as Rhodococcus_rhodochrous -RRB- ATCC 12674 , Nocardia restrictus ATCC 14887 , Mycobacterium_fortuitum UI-53387 , Pseudomonas species strain NRRL-2994 , Pseudomonas species strain NRRL B-3266 , and baker 's _ yeast . 22189865 0 10-hydroxystearic_acid 14,36 oleate_hydratase 85,101 10-hydroxystearic acid oleate hydratase MESH:C070376 29443290 Chemical Gene Production|nmod|START_ENTITY hydrolyzate|nsubj|Production hydrolyzate|nmod|END_ENTITY Production of 10-hydroxystearic_acid from oleic_acid and olive oil hydrolyzate by an oleate_hydratase from Lysinibacillus_fusiformis . 21948282 0 10-hydroxy-trans-2-decenoic_acid 21,53 IkB 98,101 10-hydroxy-trans-2-decenoic acid IkB null 18036(Tax:10090) Chemical Gene production|amod|START_ENTITY production|acl|reducing reducing|dobj|END_ENTITY Inhibitory effect of 10-hydroxy-trans-2-decenoic_acid on LPS-induced IL-6 production via reducing IkB - expression . 21948282 0 10-hydroxy-trans-2-decenoic_acid 21,53 IL-6 69,73 10-hydroxy-trans-2-decenoic acid IL-6 null 16193(Tax:10090) Chemical Gene START_ENTITY|nmod|END_ENTITY Inhibitory effect of 10-hydroxy-trans-2-decenoic_acid on LPS-induced IL-6 production via reducing IkB - expression . 12867494 2 10-hydroxyverbenone 409,428 p450 474,478 10-hydroxyverbenone p450 MESH:C000589000 1555 Chemical Gene START_ENTITY|nmod|END_ENTITY In this study , -LRB- - -RRB- - verbenone was found to be converted to 10-hydroxyverbenone by rat and human liver microsomal cytochrome p450 -LRB- p450 -RRB- enzymes . 12867494 2 10-hydroxyverbenone 409,428 p450 480,484 10-hydroxyverbenone p450 MESH:C000589000 1555 Chemical Gene enzymes|amod|START_ENTITY enzymes|appos|END_ENTITY In this study , -LRB- - -RRB- - verbenone was found to be converted to 10-hydroxyverbenone by rat and human liver microsomal cytochrome p450 -LRB- p450 -RRB- enzymes . 9014207 2 10-hydroxywarfarin 256,274 CYP1A2 207,213 10-hydroxywarfarin CYP1A2 MESH:C065719 1544 Chemical Gene CYP3A4|nmod|START_ENTITY metabolized|nmod|CYP3A4 metabolized|nmod|6 6|compound|END_ENTITY R-warfarin is metabolized primarily by CYP1A2 to 6 - _ and_8-hydroxywarfarin , by CYP3A4 to 10-hydroxywarfarin , and by carbonyl reductases to diastereoisomeric alcohols . 16035367 2 10-hydroxywarfarin 337,355 CYP3A4 270,276 10-hydroxywarfarin CYP3A4 MESH:C065719 1576 Chemical Gene quantitation|amod|START_ENTITY determined|nmod|quantitation determined|nsubjpass|activity activity|compound|END_ENTITY CYP3A4 activity was determined by the quantitation of the product , 10-hydroxywarfarin , based on separation by CE . 9014207 2 10-hydroxywarfarin 256,274 CYP3A4 246,252 10-hydroxywarfarin CYP3A4 MESH:C065719 1576 Chemical Gene END_ENTITY|nmod|START_ENTITY R-warfarin is metabolized primarily by CYP1A2 to 6 - _ and_8-hydroxywarfarin , by CYP3A4 to 10-hydroxywarfarin , and by carbonyl reductases to diastereoisomeric alcohols . 17921187 8 10-hydroxywarfarin 1606,1624 UGT 1514,1517 10-hydroxywarfarin UGT MESH:C065719 7361 Chemical Gene evaluated|conj|START_ENTITY isozymes|dep|evaluated isozymes|nsubj|none none|nmod|END_ENTITY UGT1A4 , 1A6 , 1A7 , and 2B7 did not have activity with any substrate , and none of the UGT isozymes evaluated catalyzed reactions with -LRB- R -RRB- - and -LRB- S -RRB- - warfarin , racemic warfarin , or 10-hydroxywarfarin . 17921187 8 10-hydroxywarfarin 1606,1624 UGT1A4 1430,1436 10-hydroxywarfarin UGT1A4 MESH:C065719 54657 Chemical Gene evaluated|conj|START_ENTITY isozymes|dep|evaluated have|conj|isozymes have|nsubj|END_ENTITY UGT1A4 , 1A6 , 1A7 , and 2B7 did not have activity with any substrate , and none of the UGT isozymes evaluated catalyzed reactions with -LRB- R -RRB- - and -LRB- S -RRB- - warfarin , racemic warfarin , or 10-hydroxywarfarin . 20429590 11 10-Hydroxywarfarin 1649,1667 CYP2C9 1773,1779 10-Hydroxywarfarin CYP2C9 MESH:C065719 1559 Chemical Gene inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY 10-Hydroxywarfarin , which has been reported as the second most abundant plasma metabolite , was the most potent inhibitor of CYP2C9 , displaying approximately 3-fold higher affinity than S-warfarin . 23434525 2 10-keto-NBP 353,364 M3-1 386,390 10-keto-NBP M3-1 null 10951 Chemical Gene START_ENTITY|conj|3-hydroxy-NBP 3-hydroxy-NBP|appos|END_ENTITY Our previous study showed that NBP underwent extensive metabolism in humans and that 10-keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- and NBP-11-oic_acid -LRB- M5-2 -RRB- were the major circulating metabolites . 23169608 6 10-Keto-NBP 884,895 M3-1 917,921 10-Keto-NBP M3-1 null 10951 Chemical Gene M2|amod|START_ENTITY M2|conj|END_ENTITY 10-Keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- , and M5-2 were the major circulating metabolites , wherein the areas under the curve values were 1.6 - , 2.9 - , 10.3 - , and 4.1-fold higher than that of NBP . 25847254 3 10-MDP 538,544 COX-2 616,621 10-MDP COX-2 null 4513 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 25847254 4 10-MDP 701,707 dentin_matrix_protein-1 876,899 10-MDP dentin matrix protein-1 null 1758 Chemical Gene alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|amod|END_ENTITY In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity . 26864705 4 10-MDP 708,714 HAp 849,852 10-MDP HAp null 10313 Chemical Gene monomers|appos|START_ENTITY either|nmod|monomers containing|dobj|either measured|advcl|containing measured|nmod|with with|conj|powder powder|compound|END_ENTITY The DC of three experimental adhesive formulations , containing either of the two functional monomers -LSB- 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- 10-MDP -RRB- or 4-methacryloxyethyl_trimellitic_acid_anhydride -LRB- 4-META -RRB- -RSB- or no functional monomer -LRB- no-FM ; control -RRB- , was measured with and without HAp powder added to the adhesive formulations . 25847254 5 10-MDP 987,993 heme_oxygenase-1 1079,1095 10-MDP heme oxygenase-1 null 3162 Chemical Gene induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|conj|END_ENTITY In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- . 25847254 5 10-MDP 987,993 HO-1 1097,1101 10-MDP HO-1 null 3162 Chemical Gene induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|appos|END_ENTITY In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- . 25847254 6 10-MDP 1139,1145 HO-1 1174,1178 10-MDP HO-1 null 3162 Chemical Gene effect|nmod|START_ENTITY related|nsubjpass|effect related|nmod|induction induction|nmod|END_ENTITY We evaluated whether the effect of 10-MDP was related to induction of HO-1 , and found that treatment with a selective inhibitor of HO-1 reversed production of 10-MDP-mediated pro-inflammatory cytokines and inhibition of differentiation markers . 25847254 6 10-MDP 1139,1145 HO-1 1235,1239 10-MDP HO-1 null 3162 Chemical Gene effect|nmod|START_ENTITY related|nsubjpass|effect related|conj|found found|ccomp|reversed reversed|nsubj|treatment treatment|nmod|inhibitor inhibitor|nmod|END_ENTITY We evaluated whether the effect of 10-MDP was related to induction of HO-1 , and found that treatment with a selective inhibitor of HO-1 reversed production of 10-MDP-mediated pro-inflammatory cytokines and inhibition of differentiation markers . 25847254 8 10-MDP 1596,1602 HO-1 1718,1722 10-MDP HO-1 null 3162 Chemical Gene concentrations|nmod|START_ENTITY promoted|nsubj|concentrations promoted|advcl|activating activating|dobj|induction induction|amod|END_ENTITY Taken together , the results of this study showed that minimally toxic concentrations of 10-MDP promoted an inflammatory response and suppresses odontoblastic differentiation of DPCs by activating Nrf2-mediated HO-1 induction through MAPK and NF-kB signalling . 25847254 3 10-MDP 538,544 IL-1b 630,635 10-MDP IL-1b null 3553 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 25847254 3 10-MDP 538,544 IL-6 637,641 10-MDP IL-6 null 3569 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 25847254 3 10-MDP 538,544 IL-8 646,650 10-MDP IL-8 null 3576 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 25847254 3 10-MDP 538,544 iNOS 610,614 10-MDP iNOS null 51477 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 25847254 5 10-MDP 987,993 Nrf2 1052,1056 10-MDP Nrf2 null 4780 Chemical Gene induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|appos|END_ENTITY In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- . 25847254 5 10-MDP 987,993 nuclear_factor-E2-related_factor_2 1016,1050 10-MDP nuclear factor-E2-related factor 2 null 4780 Chemical Gene induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|END_ENTITY In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- . 25847254 4 10-MDP 701,707 osterix 901,908 10-MDP osterix null 121340 Chemical Gene alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|conj|END_ENTITY In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity . 25847254 4 10-MDP 701,707 Runx2 913,918 10-MDP Runx2 null 860 Chemical Gene alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|conj|END_ENTITY In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity . 25847254 3 10-MDP 538,544 TNF-a 623,628 10-MDP TNF-a null 7124 Chemical Gene caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner . 18205319 10 10-MeBaA 1565,1573 AhR 1699,1702 10-MeBaA AhR null 25690(Tax:10116) Chemical Gene exception|nmod|START_ENTITY induced|nmod|exception induced|nmod|cells cells|acl:relcl|corresponded corresponded|nmod|END_ENTITY With the exception of 10-MeBaA , all MeBaAs induced cell proliferation in contact-inhibited WB-F344 cells , which corresponded with their ability to activate AhR . 18205319 9 10-MeBaA 1393,1401 p53 1455,1458 10-MeBaA p53 null 301300(Tax:10116) Chemical Gene induced|nsubj|START_ENTITY induced|dobj|apoptosis apoptosis|nmod|END_ENTITY Only 10-MeBaA induced apoptosis and accumulation of phosphorylated p53 , which could be associated with the induction of oxidative stress , similar to DMBA . 26864705 4 10-methacryloyloxydecyl_dihydrogen_phosphate 662,706 HAp 849,852 10-methacryloyloxydecyl dihydrogen phosphate HAp MESH:C069749 10313 Chemical Gene monomers|amod|START_ENTITY either|nmod|monomers containing|dobj|either measured|advcl|containing measured|nmod|with with|conj|powder powder|compound|END_ENTITY The DC of three experimental adhesive formulations , containing either of the two functional monomers -LSB- 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- 10-MDP -RRB- or 4-methacryloxyethyl_trimellitic_acid_anhydride -LRB- 4-META -RRB- -RSB- or no functional monomer -LRB- no-FM ; control -RRB- , was measured with and without HAp powder added to the adhesive formulations . 12238784 1 10-methacryloyloxydecyl_dihydrogen_phosphate 434,478 MDP 480,483 10-methacryloyloxydecyl dihydrogen phosphate MDP null 1800 Chemical Gene EP3MA|conj|START_ENTITY epithioalkyl_methacrylate|amod|EP3MA epithioalkyl_methacrylate|appos|END_ENTITY To develop a new surface treatment agent which improves the bond strength of adhesive resin to both non-precious and precious metals , experimental treatment agents containing both an adhesive bonding promoter for precious metals and one for non-precious metals were prepared by dissolving epithioalkyl_methacrylate -LRB- EP3MA or EP8MA -RRB- and 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- MDP -RRB- in acetone . 26744836 10 10-methoxycamptothecin 1049,1071 OAT3 1154,1158 10-methoxycamptothecin OAT3 MESH:C577311 9376 Chemical Gene 10-hydroxycamptothecin|conj|START_ENTITY CPT|amod|10-hydroxycamptothecin inhibit|nsubj|CPT inhibit|dobj|activity activity|nmod|END_ENTITY Our data revealed that CPT , 10-hydroxycamptothecin -LRB- HCPT -RRB- , 10-methoxycamptothecin -LRB- MCPT -RRB- and 9-nitrocamptothecin -LRB- 9NC -RRB- significantly inhibit the uptake activity of OAT3 . 22176677 7 10-methoxycanthin-6-one 1711,1734 cyclooxygenase_2 1572,1588 10-methoxycanthin-6-one cyclooxygenase 2 null 19225(Tax:10090) Chemical Gene IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|END_ENTITY There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one . 22176677 7 10-methoxycanthin-6-one 1711,1734 IL-6 1655,1659 10-methoxycanthin-6-one IL-6 null 16193(Tax:10090) Chemical Gene END_ENTITY|advcl|START_ENTITY There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one . 22176677 7 10-methoxycanthin-6-one 1711,1734 TNF 1619,1622 10-methoxycanthin-6-one TNF null 21926(Tax:10090) Chemical Gene IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|cyclooxygenase_2 cyclooxygenase_2|dep|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|dep|END_ENTITY There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one . 22176677 7 10-methoxycanthin-6-one 1711,1734 tumor_necrosis_factor_alpha 1590,1617 10-methoxycanthin-6-one tumor necrosis factor alpha null 21926(Tax:10090) Chemical Gene IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|cyclooxygenase_2 cyclooxygenase_2|dep|END_ENTITY There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one . 12932138 0 10-Methoxydihydrofuscin 0,23 CCR5 80,84 10-Methoxydihydrofuscin CCR5 MESH:C479848 1234 Chemical Gene START_ENTITY|appos|antagonists antagonists|nmod|receptor receptor|compound|END_ENTITY 10-Methoxydihydrofuscin , fuscinarin , and fuscin , novel antagonists of the human CCR5 receptor from Oidiodendron griseum . 21463912 1 10-methoxyhomocamptothecin 291,317 hCPT 160,164 10-methoxyhomocamptothecin hCPT null 56994 Chemical Gene improve|advcl|START_ENTITY purpose|acl|improve designed|nmod|purpose designed|nsubjpass|series series|appos|END_ENTITY A series of novel 7-acyl derivatives of homocamptothecin -LRB- hCPT -RRB- were designed and synthesized with the purpose to improve antitumor activity of hCPT , via Minisci free-radical reaction from 10-methoxyhomocamptothecin . 21463912 1 10-methoxyhomocamptothecin 291,317 hCPT 246,250 10-methoxyhomocamptothecin hCPT null 56994 Chemical Gene improve|advcl|START_ENTITY improve|dobj|activity activity|nmod|END_ENTITY A series of novel 7-acyl derivatives of homocamptothecin -LRB- hCPT -RRB- were designed and synthesized with the purpose to improve antitumor activity of hCPT , via Minisci free-radical reaction from 10-methoxyhomocamptothecin . 2145423 7 10-methyl-11-hydroxyaporphine 1170,1199 PM-1000 1161,1168 10-methyl-11-hydroxyaporphine PM-1000 MESH:C054813 1244347(Tax:272843) Chemical Gene END_ENTITY|dep|START_ENTITY On the other hand , serotonin1A_receptor agonists , -LRB- 8-hydroxy-2-di-n-propylaminotetralin , 100 and 300 micrograms/kg -RRB- and PM-1000 -LRB- 10-methyl-11-hydroxyaporphine , 1 and 3 mg/kg -RRB- , did not inhibit responses to tilt . 2145423 7 10-methyl-11-hydroxyaporphine 1170,1199 serotonin1A_receptor 1060,1080 10-methyl-11-hydroxyaporphine serotonin1A receptor MESH:C054813 24473(Tax:10116) Chemical Gene PM-1000|dep|START_ENTITY END_ENTITY|conj|PM-1000 On the other hand , serotonin1A_receptor agonists , -LRB- 8-hydroxy-2-di-n-propylaminotetralin , 100 and 300 micrograms/kg -RRB- and PM-1000 -LRB- 10-methyl-11-hydroxyaporphine , 1 and 3 mg/kg -RRB- , did not inhibit responses to tilt . 1666334 1 10-methyl-11-hydroxyaporphine 151,180 Serotonin1A_receptor 77,97 10-methyl-11-hydroxyaporphine Serotonin1A receptor MESH:C054813 24473(Tax:10116) Chemical Gene tetralin|conj|START_ENTITY -|amod|tetralin agonists|appos|- agonists|amod|END_ENTITY Serotonin1A_receptor agonists , 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin and 10-methyl-11-hydroxyaporphine , inhibited electrical stimulation-induced contraction of the guinea-pig ileum . 9066300 0 10-methyl-13-demethyl 104,125 rhodopsin 145,154 10-methyl-13-demethyl rhodopsin null 509933(Tax:9913) Chemical Gene retinal|amod|START_ENTITY retinal|acl|containing containing|dobj|END_ENTITY Steric hindrance between chromophore substituents as the driving force of rhodopsin photoisomerization : 10-methyl-13-demethyl retinal containing rhodopsin . 9066300 0 10-methyl-13-demethyl 104,125 rhodopsin 74,83 10-methyl-13-demethyl rhodopsin null 509933(Tax:9913) Chemical Gene retinal|amod|START_ENTITY hindrance|dep|retinal hindrance|nmod|substituents substituents|nmod|force force|nmod|photoisomerization photoisomerization|compound|END_ENTITY Steric hindrance between chromophore substituents as the driving force of rhodopsin photoisomerization : 10-methyl-13-demethyl retinal containing rhodopsin . 9066300 1 10-methyl-13-demethyl 187,208 rhodopsin 278,287 10-methyl-13-demethyl rhodopsin null 509933(Tax:9913) Chemical Gene retinal|amod|START_ENTITY analogue|appos|retinal synthesized|nsubjpass|analogue synthesized|nmod|END_ENTITY A visual chromophore analogue , 10-methyl-13-demethyl -LRB- dm -RRB- retinal , was synthesized and reconstituted with bleached bovine rhodopsin to form a visual pigment derivative with absorbance maximum at 505 nm . 24677503 8 10-methyl-aplog-1 1189,1206 ATX 1266,1269 10-methyl-aplog-1 ATX null 140477(Tax:10090) Chemical Gene START_ENTITY|appos|analog analog|nmod|aplysiatoxin aplysiatoxin|appos|END_ENTITY We have recently identified 10-methyl-aplog-1 -LRB- 26 -RRB- , a simplified analog of tumor-promoting aplysiatoxin -LRB- ATX -RRB- , as a possible therapeutic lead for cancer . 24744020 7 10-methyl_C17 664,677 C17 648,651 10-methyl C17 C17 null 54360 Chemical Gene 0|nummod|START_ENTITY 8c|conj|0 fatty_acids|dep|8c fatty_acids|dep|0 0|appos|END_ENTITY The major fatty_acids were iso-C16 : 0 , C17 : 1 8c and 10-methyl_C17 : 0 . 23178730 6 10-methyl_C18 1067,1080 C18 1041,1044 10-methyl C18 C18 null 27241 Chemical Gene 0|appos|START_ENTITY 9c|dep|0 END_ENTITY|dep|9c The major cellular fatty_acids were C18 : 1 9c , iso-C15 : 0 , 10-methyl_C18 : 0 -LRB- tuberculostearic_acid -RRB- , C16 : 0 , C18 : 0 and iso-C16 : 0 . 27381319 8 10-methyl_C18 756,769 C18 739,742 10-methyl C18 C18 null 27241 Chemical Gene 9c|appos|START_ENTITY fatty_acids|dep|9c fatty_acids|dep|0 0|appos|END_ENTITY The major fatty_acids were iso-C16 : 0 , C18 : 1 9c , 10-methyl_C18 : 0 and anteiso-C17 : 0 . 27902232 7 10-methyl_C18 962,975 C18 945,948 10-methyl C18 C18 null 27241 Chemical Gene 9c|appos|START_ENTITY END_ENTITY|dep|9c The major fatty_acids -LRB- C18 : 1 9c , 10-methyl_C18 : 0 , C16 : 0 , C18 ___ : ___ 0 , _ C16 : 0 2-OH -RRB- were consistent with the fatty_acid patterns reported for members of the genus Aeromicrobium . 10833330 7 10-methylenetetrahydrofolate 1418,1446 folate_receptor-alpha 1509,1530 10-methylenetetrahydrofolate folate receptor-alpha null 2348 Chemical Gene reductase|amod|START_ENTITY alleles|conj|reductase alleles|conj|region region|nmod|gene gene|amod|END_ENTITY The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene . 10833330 7 10-methylenetetrahydrofolate 1418,1446 FR-alpha 1532,1540 10-methylenetetrahydrofolate FR-alpha null 79874 Chemical Gene reductase|amod|START_ENTITY alleles|conj|reductase alleles|conj|region region|nmod|gene gene|appos|END_ENTITY The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene . 10528242 1 10-methylenetetrahydrofolate 249,277 MTHFR 289,294 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY 5|appos|reductase 5|appos|END_ENTITY A number of studies have demonstrated that the common polymorphism 677C -- > T in the gene encoding 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- leads to a thermolabile variant with decreased enzyme activity and to mildly elevated plasma homocysteine . 10600168 2 10-methylenetetrahydrofolate 287,315 MTHFR 251,256 10-methylenetetrahydrofolate MTHFR MESH:C013123 4524 Chemical Gene 5-methyltetrahydrofolate|amod|START_ENTITY reduction|amod|5-methyltetrahydrofolate used|nsubj|reduction catalyzes|ccomp|used catalyzes|nsubj|END_ENTITY MTHFR catalyzes the reduction of 5 , 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , used to methylate_homocysteine in methionine synthesis . 10833330 7 10-methylenetetrahydrofolate 1418,1446 MTHFR 1458,1463 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY reductase|appos|END_ENTITY The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene . 15022402 0 10-methylenetetrahydrofolate 39,67 MTHFR 79,84 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY reductase|appos|END_ENTITY -LSB- Frequency of C677T polymorphism of 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- in Chilean mothers of spina_bifida cases and controls -RSB- . 17492607 4 10-methylenetetrahydrofolate 610,638 MTHFR 650,655 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY reductase|appos|END_ENTITY Both plasma levels of homocysteine -LRB- Hc -RRB- and the mutation of the gene for 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- were determined . 20229089 2 10-methylenetetrahydrofolate 274,302 MTHFR 314,319 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY 5|appos|reductase 5|appos|END_ENTITY The C677T polymorphism of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene has been postulated to be a genetic risk factor for venous_thromboembolism and osteonecrosis in Caucasians , but this relationship has not been established in other populations . 20863444 1 10-methylenetetrahydrofolate 156,184 MTHFR 196,201 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY reductase|appos|END_ENTITY OBJECTIVES : To determine whether 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- rs1801133C/T , rs1801131A/C , rs2274976A/G , rs2066462C/T genetic polymorphisms are associated with clinical response and adverse effects -LRB- AEs -RRB- of methotrexate -LRB- MTX -RRB- treatment in Chinese Han patients with rheumatoid_arthritis -LRB- RA -RRB- . 22540831 2 10-methylenetetrahydrofolate 253,281 MTHFR 293,298 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY show|dobj|reductase Studies|dep|show Studies|dep|END_ENTITY Studies in Western populations show that 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- 677C > T and Factor V -LRB- F5 -RRB- 1691G > A -LRB- Leiden -RRB- polymorphisms are commonly associated with pre-eclampsia and recurrent spontaneous pregnancy_loss . 26717388 2 10-methylenetetrahydrofolate 435,463 MTHFR 475,480 10-methylenetetrahydrofolate MTHFR null 4524 Chemical Gene reductase|amod|START_ENTITY reductase|appos|END_ENTITY This study used the case-control method to investigate the association between plasma homocysteine and the C677T gene polymorphism of its key metabolic enzyme , 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- , and early renal_damage in a hypertensive Chinese Han population.A total of 379 adult essential hypertensive patients were selected as the study subjects . 1626951 2 10-methylene_tetrahydrofolate 272,301 thymidylate_synthase 216,236 10-methylene tetrahydrofolate thymidylate synthase null 7298 Chemical Gene binds|xcomp|START_ENTITY binds|advmod|tightly tightly|nmod|END_ENTITY FdUMP which is an active metabolite of 5-FU binds tightly to thymidylate_synthase in the presence of the cofactor 5 , 10-methylene_tetrahydrofolate . 15666596 1 10-Methylenetetrahydrofolate 114,142 MTHFR 154,159 10-Methylenetetrahydrofolate MTHFR null 4524 Chemical Gene Reductase|amod|START_ENTITY Reductase|appos|END_ENTITY 5 , _ 10-Methylenetetrahydrofolate Reductase -LRB- MTHFR -RRB- is one of the key enzymes in the metabolism of homocysteine , where it catalyses its remethylation . 27147217 6 10-methylene_tetrahydromethanopterin 1190,1226 bpss0686 1157,1165 10-methylene tetrahydromethanopterin bpss0686 null 3095474(Tax:272560) Chemical Gene reductase|amod|START_ENTITY encoding|dobj|reductase encoding|nmod|bprR bprR|conj|END_ENTITY Inactivation of the entire BprRS TCSTS -LRB- bprRS double mutant -RRB- resulted in altered expression of only nine genes , including both bprR and bprS , five phage-related genes and bpss0686 , encoding a putative 5 , 10-methylene_tetrahydromethanopterin reductase involved in one carbon metabolism . 2002449 2 10-methyl_ether 584,599 COMT 462,466 10-methyl ether COMT null 1312 Chemical Gene using|nmod|START_ENTITY END_ENTITY|acl|using In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine -LRB- 10,11-dihydroxyaporphine -RRB- is converted in high yield into its 10-methyl_ether , apocodeine . 7057422 8 10-methylfolic_acid 1155,1174 THF 1098,1101 10-methylfolic acid THF MESH:C008622 21831(Tax:10090) Chemical Gene give|dobj|START_ENTITY alkylated|xcomp|give alkylated|advmod|END_ENTITY Also , both folic_acid and 5 - -LRB- CHO -RRB- - THF were reductively alkylated with formaldehyde to give 10-methylfolic_acid -LRB- 6 -RRB- and 5 - -LRB- CHO -RRB- -10 - -LRB- CH3 -RRB- - THF -LRB- 28 -RRB- , respectively . 7057422 8 10-methylfolic_acid 1155,1174 THF 1200,1203 10-methylfolic acid THF MESH:C008622 21831(Tax:10090) Chemical Gene give|dobj|START_ENTITY give|dep|-10 -10|dep|CH3 CH3|dep|END_ENTITY Also , both folic_acid and 5 - -LRB- CHO -RRB- - THF were reductively alkylated with formaldehyde to give 10-methylfolic_acid -LRB- 6 -RRB- and 5 - -LRB- CHO -RRB- -10 - -LRB- CH3 -RRB- - THF -LRB- 28 -RRB- , respectively . 16411756 3 10-methylretinal 700,716 C10 670,673 10-methylretinal C10 null 113246 Chemical Gene strongly|advcl|START_ENTITY C13|advmod|strongly C13|compound|END_ENTITY After relaxation inside the protein , all chromophores show significant nonplanar distortions from C10 to C13 , most strongly for 10-methylretinal and least pronounced for 9-demethylretinal . 16411756 3 10-methylretinal 700,716 C13 677,680 10-methylretinal C13 null 3229 Chemical Gene strongly|advcl|START_ENTITY END_ENTITY|advmod|strongly After relaxation inside the protein , all chromophores show significant nonplanar distortions from C10 to C13 , most strongly for 10-methylretinal and least pronounced for 9-demethylretinal . 26860474 5 10-methyl_retinal 857,874 Rhodopsin 694,703 10-methyl retinal Rhodopsin null 6010 Chemical Gene stepwise|conj|START_ENTITY proceeds|xcomp|stepwise proceeds|nsubj|formation formation|compound|END_ENTITY Rhodopsin formation proceeds stepwise with prolonged lifetimes especially for 9-demethyl_retinal -LRB- longest lifetime 3 = 7500 s , cf. , 3500 s for retinal -RRB- , and for 10-methyl_retinal -LRB- 3 = 7850 s -RRB- . 1504339 2 10-methyl-undecanoic_acid 432,457 RS1 549,552 10-methyl-undecanoic acid RS1 null 6247 Chemical Gene A|dep|START_ENTITY assigned|nmod|A residues|acl|assigned confirm|dobj|residues confirm|conj|establish establish|dobj|residues residues|nmod|A1 A1|conj|END_ENTITY The results confirm the residues previously assigned to Factor A -LRB- n-undecanoic acid -RRB- and B -LRB- 10-methyl-undecanoic_acid -RRB- and establish the residues of Factor A1 -LRB- 9-methyl-decanoic_acid -RRB- , B1 -LRB- n-dodecanoic_acid -RRB- , RS1 -LRB- 8-methyl-nonanoic_acid -RRB- , RS2 -LRB- n-decanoic_acid -RRB- , and RS3 _ -LRB- n-tridecanoic_acid -RRB- . 2523370 3 10-methylundecanoic_acid 478,502 RS-1 405,409 10-methylundecanoic acid RS-1 null 6247 Chemical Gene chains|amod|START_ENTITY having|dobj|chains teicoplanins|acl|having teicoplanins|nsubj|Two Two|acl|named named|xcomp|END_ENTITY Two of them , named RS-1 and RS-2 , were shown to be teicoplanins having as fatty_acid chains 10-methylundecanoic_acid and n-dodecanoic_acid , respectively . 26272165 2 10MeV 521,526 CaF2 580,584 10MeV CaF2 null 9337 Chemical Gene power|conj|START_ENTITY MgF2|nmod|power MgF2|conj|END_ENTITY The optimal moderator materials were found to be MgF2 for proton energies less than 10MeV because of lower required accelerator beam power and CaF2 for higher proton energies because of lower photon dose rate at the treatment position after neutron irradiation . 6262173 1 10-micromilligram_Dexamethasone 143,174 CNP 291,294 10-micromilligram Dexamethasone CNP null 1267 Chemical Gene START_ENTITY|ref|which cause|nsubj|which cause|dobj|differentiation differentiation|nmod|phosphohydrolase phosphohydrolase|appos|END_ENTITY Cultures of glial cell lines -LRB- C6 -RRB- were exposed to 10-micromilligram_Dexamethasone which is known to cause morphological differentiation and induction of 2 ' ,3 ' - cyclic_nucleotide_3 ' - phosphohydrolase -LRB- CNP -RRB- in these cells . 2934548 8 10_mM-phosphate 1067,1082 ATPase 1096,1102 10 mM-phosphate ATPase null 1769 Chemical Gene affected|advcl|START_ENTITY affected|conj|activity activity|amod|END_ENTITY The maximum contraction velocity of both fast and slow fibres was not affected by 10_mM-phosphate , nor was the ATPase activity of the slow fibres during isometric contraction . 12590612 5 10-N-acetamidodecyl_chloromethyl_ketone 621,660 cellular_retinol-binding_protein_I 673,707 10-N-acetamidodecyl chloromethyl ketone cellular retinol-binding protein I null 19659(Tax:10090) Chemical Gene START_ENTITY|conj|END_ENTITY Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol . 12590612 5 10-N-acetamidodecyl_chloromethyl_ketone 621,660 CRBP 709,713 10-N-acetamidodecyl chloromethyl ketone CRBP null 19659(Tax:10090) Chemical Gene START_ENTITY|appos|END_ENTITY Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol . 12590612 5 10-N-acetamidodecyl_chloromethyl_ketone 621,660 lecithin_retinol_acyltransferase 576,608 10-N-acetamidodecyl chloromethyl ketone lecithin retinol acyltransferase null 79235(Tax:10090) Chemical Gene END_ENTITY|nmod|START_ENTITY Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol . 12590612 5 10-N-acetamidodecyl_chloromethyl_ketone 621,660 LRAT 610,614 10-N-acetamidodecyl chloromethyl ketone LRAT null 79235(Tax:10090) Chemical Gene lecithin_retinol_acyltransferase|nmod|START_ENTITY lecithin_retinol_acyltransferase|appos|END_ENTITY Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol . 4186 0 10-N-acylaminophenothiazine 21,48 SAS 10,13 10-N-acylaminophenothiazine SAS null 362890(Tax:10116) Chemical Gene Effect|appos|START_ENTITY Effect|nmod|END_ENTITY Effect of SAS -LRB- a new 10-N-acylaminophenothiazine -RRB- on gastric secretion and ulceration in rats . 23937156 10 10-NCP 1149,1155 Drp1 1245,1249 10-NCP Drp1 null 10059 Chemical Gene able|nsubj|START_ENTITY able|ccomp|increase increase|xcomp|verifying verifying|dobj|result result|nmod|depletion depletion|amod|END_ENTITY Further , 10-NCP was able increase average mitochondrial size and length verifying a functional result of Drp1 depletion in these neurons . 12372420 0 10-nitro-folate 110,125 folate_receptor_beta 129,149 10-nitro-folate folate receptor beta MESH:C468779 2350 Chemical Gene binding|nmod|START_ENTITY peroxynitrite|conj|binding folic_acid|nmod|peroxynitrite folic_acid|nmod|END_ENTITY Nitration and chlorination of folic_acid by peroxynitrite and hypochlorous_acid , and the selective binding of 10-nitro-folate to folate_receptor_beta . 12372420 6 10-nitro-folate 822,837 FR-beta 870,877 10-nitro-folate FR-beta MESH:C468779 2350 Chemical Gene showed|nsubj|START_ENTITY showed|nmod|END_ENTITY The 10-nitro-folate showed the selective binding to FR-beta , compared to folic_acid . 2586490 5 10-nitrogen 1113,1124 FPGS 1246,1250 10-nitrogen FPGS null 14287(Tax:10090) Chemical Gene substituents|nmod|START_ENTITY analogs|nmod|substituents series|nmod|analogs studied|nsubjpass|series found|advcl|studied found|xcomp|diminish diminish|nmod|substrates substrates|nmod|END_ENTITY When a homologous series of 5,8-dideazafolic _ acid analogs with hydrocarbon substituents on the 10-nitrogen were studied , these substituents were found to diminish the efficiency of utilization of these analogs as substrates for FPGS ; this effect increased with increasing chain length of the hydrocarbon . 16272718 3 10-nitro-goniothalamin 427,449 vp-16 636,641 10-nitro-goniothalamin vp-16 null 3054 Chemical Gene derivatives|amod|START_ENTITY gave|nsubj|derivatives gave|advcl|microg/ml microg/ml|nsubj|that that|nmod|etoposide etoposide|dep|END_ENTITY The derivatives 10-nitro-goniothalamin and 10-amino-goniothalamin gave selective inhibition concentration -LRB- IC50 -RRB- of 1.10 and 1.14 microg/ml , respectively , against human stomach_cancer SGC-7901 cells , while that of etoposide -LRB- vp-16 -RRB- as the positive control was 6.07 microg/ml . 20593759 0 10-nitrolinoleic_acid 53,74 PPAR-gamma 34,44 10-nitrolinoleic acid PPAR-gamma null 5468 Chemical Gene START_ENTITY|nsubj|synthesis synthesis|nmod|agonist agonist|amod|END_ENTITY Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic_acid . 20593759 1 10-nitrolinoleic_acid 160,181 PPAR-gamma 100,110 10-nitrolinoleic acid PPAR-gamma null 5468 Chemical Gene dienoic_acid|dep|START_ENTITY prepared|nsubjpass|dienoic_acid ligand|conj|prepared ligand|nsubj|END_ENTITY The naturally occurring PPAR-gamma ligand 10-nitrooctadeca-9 -LRB- E -RRB- ,12 -LRB- Z -RRB- - dienoic_acid -LRB- 10-nitrolinoleic_acid -RRB- -LRB- 2a -RRB- was prepared as a single regio - and geometrical isomer in a practical eight-step , convergent sequence . 26598510 4 10-nitro-octadec-9-enoic_acid 672,701 AngII 632,637 10-nitro-octadec-9-enoic acid AngII null 11606(Tax:10090) Chemical Gene angiotensin_II|dep|START_ENTITY angiotensin_II|appos|END_ENTITY METHODS AND RESULTS : Wild-type C57BL6/J mice were treated for 2 weeks with angiotensin_II -LRB- AngII -RRB- and vehicle or nitro-oleic_acid -LRB- 10-nitro-octadec-9-enoic_acid , OA-NO2 , 6 mg/kg body weight -RRB- via subcutaneous osmotic minipumps . 26598510 4 10-nitro-octadec-9-enoic_acid 672,701 angiotensin_II 616,630 10-nitro-octadec-9-enoic acid angiotensin II null 11606(Tax:10090) Chemical Gene END_ENTITY|dep|START_ENTITY METHODS AND RESULTS : Wild-type C57BL6/J mice were treated for 2 weeks with angiotensin_II -LRB- AngII -RRB- and vehicle or nitro-oleic_acid -LRB- 10-nitro-octadec-9-enoic_acid , OA-NO2 , 6 mg/kg body weight -RRB- via subcutaneous osmotic minipumps . 21357422 3 10-nitro-octadec-9-enoic_acid 604,633 Keap1 769,774 10-nitro-octadec-9-enoic acid Keap1 MESH:C069772 9817 Chemical Gene -|conj|START_ENTITY activate|nsubj|- activate|advcl|focusing focusing|nmod|modifications modifications|nmod|cysteines cysteines|nmod|END_ENTITY In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses . 21357422 3 10-nitro-octadec-9-enoic_acid 604,633 Nrf2 679,683 10-nitro-octadec-9-enoic acid Nrf2 MESH:C069772 4780 Chemical Gene -|conj|START_ENTITY activate|nsubj|- activate|dobj|END_ENTITY In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses . 21357422 3 10-nitro-octadec-9-enoic_acid 604,633 Nrf2 754,758 10-nitro-octadec-9-enoic acid Nrf2 MESH:C069772 4780 Chemical Gene -|conj|START_ENTITY activate|nsubj|- activate|advcl|focusing focusing|nmod|modifications modifications|nmod|cysteines cysteines|nmod|Keap1 Keap1|amod|END_ENTITY In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses . 21252222 6 10-nitrooleate 1084,1098 ALDH-2 1134,1140 10-nitrooleate ALDH-2 null 217 Chemical Gene prostaglandin_J|conj|START_ENTITY 4-Hydroxynonenal|appos|prostaglandin_J caused|nsubj|4-Hydroxynonenal caused|dobj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY 4-Hydroxynonenal , an oxidized prostaglandin_J -LRB- 2 -RRB- , and 9 - or 10-nitrooleate caused a significant inhibition of ALDH-2 activity , which was improved in the presence of Mg -LRB- 2 + -RRB- and Ca -LRB- 2 + -RRB- . 28739872 8 10-nitro-oleic_acid 1331,1350 MKK3 1482,1486 10-nitro-oleic acid MKK3 MESH:C521487 303200(Tax:10116) Chemical Gene reduced|nsubj|START_ENTITY reduced|advcl|obstructing obstructing|dobj|access access|compound|END_ENTITY In contrast , the anti-inflammatory agent 10-nitro-oleic_acid -LRB- NO2-OA -RRB- , a component of the Mediterranean diet , reduced p38a activation and covalently modified Cys119/Cys162 , likely obstructing MKK3 access . 24368768 6 10-nitro-oleic_acid 1297,1316 PPARy 1318,1323 10-nitro-oleic acid PPARy MESH:C521487 5468 Chemical Gene synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|nsubj|agonists agonists|compound|END_ENTITY Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB . 24368768 6 10-nitro-oleic_acid 1297,1316 PPARy 1355,1360 10-nitro-oleic acid PPARy MESH:C521487 5468 Chemical Gene synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|dobj|expression expression|amod|END_ENTITY Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB . 24368768 6 10-nitro-oleic_acid 1297,1316 PPARy 1581,1586 10-nitro-oleic acid PPARy MESH:C521487 5468 Chemical Gene synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|conj|reversed reversed|dep|inhibiting inhibiting|conj|promoting promoting|dobj|inhibitory inhibitory|nmod|END_ENTITY Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB . 6898427 1 10-nitro-so-trans-anti-cys-perhydroacridine 220,263 MT-2 265,269 10-nitro-so-trans-anti-cys-perhydroacridine MT-2 null 17750(Tax:10090) Chemical Gene START_ENTITY|appos|END_ENTITY Chemotherapeutic activity of various benzylpenicillin combinations with 10-nitro-so-trans-anti-cys-perhydroacridine -LRB- MT-2 -RRB- was studied on 2 experimental staphylococcal_infections caused by pathogenic penicillin resistant strains of staphylococci . 7119643 5 10nM-domperidone 646,662 prolactin 665,674 10nM-domperidone prolactin null 24683(Tax:10116) Chemical Gene treated|advcl|START_ENTITY began|advcl|treated began|nsubj|secretion secretion|compound|END_ENTITY When glands were treated with 10nM-domperidone , prolactin secretion began to decline after the first hour , reaching a maximum of 40-50 % inhibition after a further 90 min . 27285083 4 10-NMe2 688,695 NMe2 620,624 10-NMe2 NMe2 null 4831 Chemical Gene group|amod|START_ENTITY consists|nmod|group consists|nsubj|specifics specifics|nmod|/ /|amod|END_ENTITY At the same time , unexpected specifics of the protonated NMe2 / - N = systems consists in a strong shift of the NH proton to the 10-NMe2 group contrary to the `` aniline-pyridine '' basicity rule . 27113852 2 10nM_estradiol 518,532 fshb 406,410 10nM estradiol fshb null 402919(Tax:7955) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|levels levels|amod|END_ENTITY In our present study , we first observed that fshb and lhb mRNA levels in the pituitary of male adult zebrafish were greatly inhibited by 3 weeks exposure to 10nM_estradiol -LRB- E2 -RRB- . 27113852 2 10nM_estradiol 518,532 lhb 415,418 10nM estradiol lhb null 402917(Tax:7955) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|levels levels|amod|fshb fshb|conj|END_ENTITY In our present study , we first observed that fshb and lhb mRNA levels in the pituitary of male adult zebrafish were greatly inhibited by 3 weeks exposure to 10nM_estradiol -LRB- E2 -RRB- . 15107464 7 10-N-nonyl_acridine 1167,1186 Bid 1225,1228 10-N-nonyl acridine Bid null 637 Chemical Gene orange|amod|START_ENTITY dye|appos|orange suppress|nsubj|dye suppress|xcomp|binding binding|nsubj|END_ENTITY Like the binding to the mitochondria , this interaction could not be blocked by the mutation in the BH3 domain or by Bcl-x -LRB- L. -RRB- However , a cardiolipin-specific dye , 10-N-nonyl_acridine orange , could preferentially suppress Bid binding to the mitochondrial contact site and inhibit Bid-induced mitochondrial cristae reorganization and cytochrome_c release . 15107464 7 10-N-nonyl_acridine 1167,1186 cytochrome_c 1336,1348 10-N-nonyl acridine cytochrome c null 54205 Chemical Gene orange|amod|START_ENTITY dye|appos|orange suppress|nsubj|dye suppress|conj|inhibit inhibit|dobj|reorganization reorganization|conj|release release|amod|END_ENTITY Like the binding to the mitochondria , this interaction could not be blocked by the mutation in the BH3 domain or by Bcl-x -LRB- L. -RRB- However , a cardiolipin-specific dye , 10-N-nonyl_acridine orange , could preferentially suppress Bid binding to the mitochondrial contact site and inhibit Bid-induced mitochondrial cristae reorganization and cytochrome_c release . 17682315 6 10-N-nonyl_acridine_orange 931,957 annexin_V 866,875 10-N-nonyl acridine orange annexin V null 25673(Tax:10116) Chemical Gene fluorescence|nmod|START_ENTITY loss|nmod|fluorescence staining|conj|loss staining|amod|END_ENTITY Apoptosis was measured by annexin_V and propidium_iodide staining , loss of fluorescence of 10-N-nonyl_acridine_orange -LRB- NAO -RRB- , a cardiolipin specific fluorescent dye , and cleavage of pro-caspase-9 by western blot analysis . 22009280 4 10-N-nonyl_acridine_orange 612,638 LIF 688,691 10-N-nonyl acridine orange LIF null 3976 Chemical Gene interaction|amod|START_ENTITY based|nmod|interaction based|nmod|cardiolipin cardiolipin|acl|using using|dobj|CE CE|nmod|detection detection|compound|END_ENTITY The method presented is based on the online 10-N-nonyl_acridine_orange -LRB- NAO -RRB- interaction with cardiolipin using CE with LIF detection . 23211592 4 10-N-nonyl-acridine_orange 469,495 p21 431,434 10-N-nonyl-acridine orange p21 null 1026 Chemical Gene staining|amod|START_ENTITY measured|nmod|staining cells|dep|measured cells|amod|END_ENTITY We found that there was a significant increase in the mitochondrial mass of p21 -LRB- - / - -RRB- HCT116 cells , as measured by 10-N-nonyl-acridine_orange staining , as well as an increase in the mitochondrial DNA content . 24140437 9 10-NO 1387,1392 caveolin-1 1424,1434 10-NO caveolin-1 null 12389(Tax:10090) Chemical Gene 9-NO|conj|START_ENTITY upregulated|nsubj|9-NO upregulated|dobj|expression expression|nmod|END_ENTITY 9-NO and 10-NO also upregulated expression of caveolin-1 , the major structural component of caveolae . 24650615 7 10-nonadecenoic_acid_methyl_ester 729,762 FAME 620,624 10-nonadecenoic acid methyl ester FAME null 554188 Chemical Gene palmitic_acid_methyl_ester|conj|START_ENTITY palmitic_acid_methyl_ester|nsubj|END_ENTITY The major FAME contained in the biodiesel were palmitic_acid_methyl_ester -LRB- C16 :0 -RRB- , oleic_acid methyl ester -LRB- C18 :1 -RRB- and 10-nonadecenoic_acid_methyl_ester -LRB- C19 :1 -RRB- . 24773391 0 10-nornaltrexones 25,42 Toll-like_receptor_4 61,81 10-nornaltrexones Toll-like receptor 4 null 7099 Chemical Gene START_ENTITY|nmod|search search|nmod|antagonists antagonists|compound|END_ENTITY Synthesis of enantiopure 10-nornaltrexones in the search for Toll-like_receptor_4 antagonists and opioid ligands . 3951252 1 1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine 170,219 ALP 221,224 1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine ALP null 470 Chemical Gene START_ENTITY|appos|END_ENTITY A panel of 16 human hematopoietic cell lines was tested for sensitivity to racemic 1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine -LRB- ALP -RRB- . 7849275 3 1-0-octadecyl_2-0-methylglycero_phosphocholine 805,851 phospholipase_A2 861,877 1-0-octadecyl 2-0-methylglycero phosphocholine phospholipase A2 MESH:C076164 29526(Tax:10116) Chemical Gene di-O-hexadecylglycerophosphocholine|conj|START_ENTITY lowered|nsubj|di-O-hexadecylglycerophosphocholine lowered|dobj|activity activity|amod|END_ENTITY When introduced into the culture medium at 1 , 5 or 10 microM , the membrane phospholipid analogue 1,2 di-O-hexadecylglycerophosphocholine -LRB- dihexadecyl-GPC -RRB- , but not the lysolecithin analogue 1-0-octadecyl_2-0-methylglycero_phosphocholine , lowered phospholipase_A2 activity with either labelling method . 2308973 6 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine 886,939 ALP 941,944 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine ALP null 11691(Tax:10090) Chemical Gene START_ENTITY|appos|END_ENTITY Lethally irradiated Balb/c mice were injected with normal bone marrow cells containing 1-2 % leukemic cells -LRB- WEHI III-B -RRB- to simulate a remission marrow after the cells were incubated in vitro for 24 hours with 0-100 ug/ml of 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine -LRB- ALP -RRB- . 3775692 1 1-0-octadecyl_Paf-acether 248,273 thrombin 138,146 1-0-octadecyl Paf-acether thrombin null 100009146(Tax:9986) Chemical Gene 1-0-hexadecyl_Paf-acether|conj|START_ENTITY Collagen|amod|1-0-hexadecyl_Paf-acether Collagen|appos|END_ENTITY Collagen -LRB- 10-40 micrograms kg-1 -RRB- , thrombin -LRB- 1-10 units kg-1 -RRB- , adenosine_diphosphate -LRB- ADP ; 3-300 micrograms kg-1 -RRB- , 1-0-hexadecyl_Paf-acether and 1-0-octadecyl_Paf-acether -LRB- 1-300 ng kg-1 -RRB- administered by bolus intravenous injection each caused dose-dependent thrombocytopoenia accompanied by marked hypotension in anaesthetized rabbits . 11411558 3 10-O-demethylemetine 796,816 CYP2D6 662,668 10-O-demethylemetine CYP2D6 null 1565 Chemical Gene emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing able|conj|participated able|nsubj|CYP3A4 CYP3A4|conj|END_ENTITY CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine . 11411558 3 10-O-demethylemetine 796,816 CYP3A4 651,657 10-O-demethylemetine CYP3A4 null 1576 Chemical Gene emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing able|conj|participated able|nsubj|END_ENTITY CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine . 11411558 3 10-O-demethylemetine 796,816 CYP3A4 744,750 10-O-demethylemetine CYP3A4 null 1576 Chemical Gene emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing participated|nsubj|END_ENTITY CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine . 17009856 1 10-OH 123,128 EGFR 219,223 10-OH EGFR null 1956 Chemical Gene camptothecin|appos|START_ENTITY act|nsubj|camptothecin act|nmod|inhibitor inhibitor|appos|END_ENTITY The chemotherapeutic agent camptothecin , 10-OH -LRB- CPT,10-OH -RRB- , was shown to act synergistically with the epithelial_growth_factor_receptor -LRB- EGFR -RRB- inhibitor -LRB- AG1478 -RRB- against several transformed cell lines . 17009856 1 10-OH 123,128 epithelial_growth_factor_receptor 184,217 10-OH epithelial growth factor receptor null 1956 Chemical Gene camptothecin|appos|START_ENTITY act|nsubj|camptothecin act|nmod|inhibitor inhibitor|compound|END_ENTITY The chemotherapeutic agent camptothecin , 10-OH -LRB- CPT,10-OH -RRB- , was shown to act synergistically with the epithelial_growth_factor_receptor -LRB- EGFR -RRB- inhibitor -LRB- AG1478 -RRB- against several transformed cell lines . 16190932 13 10-OHCBZ 2157,2165 MDR1 2123,2127 10-OHCBZ MDR1 null 5243 Chemical Gene concentration|nummod|START_ENTITY correlated|nmod|concentration correlated|nsubjpass|level level|nmod|expression expression|nmod|END_ENTITY The level of expression of MDR1 is inversely correlated with 10-OHCBZ concentration in the epileptic tissue . 16190932 2 10-OHCBZ 572,580 MDR1 551,555 10-OHCBZ MDR1 null 5243 Chemical Gene levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|P-glycoprotein P-glycoprotein|dep|P-gp P-gp|conj|END_ENTITY We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens . 16190932 2 10-OHCBZ 572,580 MDR1 713,717 10-OHCBZ MDR1 null 5243 Chemical Gene levels|nummod|START_ENTITY determining|dobj|levels determining|advcl|measuring measuring|ccomp|substrate substrate|conj|relation relation|nmod|level level|nmod|expression expression|nmod|END_ENTITY We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens . 16190932 8 10-OHCBZ 1565,1573 MDR1 1647,1651 10-OHCBZ MDR1 null 5243 Chemical Gene ratio|nummod|START_ENTITY ratio|conj|level level|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY A significant inverse linear correlation was found between 10-OHCBZ brain-to-plasma concentration ratio and the level of brain expression of MDR1 mRNA . 16190932 2 10-OHCBZ 572,580 P-glycoprotein 527,541 10-OHCBZ P-glycoprotein null 5243 Chemical Gene levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|END_ENTITY We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens . 16190932 12 10-OHCBZ 1981,1989 P-gp 2090,2094 10-OHCBZ P-gp null 283871 Chemical Gene appear|nsubj|START_ENTITY appear|conj|acts acts|nmod|substrate substrate|nmod|END_ENTITY 10-OHCBZ does not appear to cross the blood-brain barrier by simple diffusion , and it acts as a substrate of P-gp . 16190932 2 10-OHCBZ 572,580 P-gp 543,547 10-OHCBZ P-gp null 283871 Chemical Gene levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|P-glycoprotein P-glycoprotein|dep|END_ENTITY We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens . 16190932 2 10-OHCBZ 572,580 P-gp 656,660 10-OHCBZ P-gp null 283871 Chemical Gene levels|nummod|START_ENTITY determining|dobj|levels determining|advcl|measuring measuring|ccomp|substrate substrate|nmod|END_ENTITY We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens . 16190932 5 10-OHCBZ 1133,1141 P-gp 1164,1168 10-OHCBZ P-gp null 283871 Chemical Gene ability|nmod|START_ENTITY ability|acl|act act|nmod|substate substate|nmod|END_ENTITY The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor . 16190932 5 10-OHCBZ 1133,1141 P-gp 1252,1256 10-OHCBZ P-gp null 283871 Chemical Gene ability|nmod|START_ENTITY evaluated|nsubjpass|ability evaluated|advcl|measuring measuring|nmod|lines lines|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor . 16190932 5 10-OHCBZ 1133,1141 P-gp 1300,1304 10-OHCBZ P-gp null 283871 Chemical Gene ability|nmod|START_ENTITY evaluated|nsubjpass|ability evaluated|advcl|measuring measuring|nmod|lines lines|acl|expressing expressing|nmod|presence presence|nmod|inhibitor inhibitor|compound|END_ENTITY The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor . 16190932 9 10-OHCBZ 1715,1723 P-gp 1752,1756 10-OHCBZ P-gp null 283871 Chemical Gene levels|nummod|START_ENTITY levels|nmod|cells cells|nmod|expression expression|compound|END_ENTITY In vitro uptake studies demonstrated lower intracellular 10-OHCBZ levels in cells with higher P-gp expression . 16132345 15 10-OH-CPT 3010,3019 CPT-11 2980,2986 10-OH-CPT CPT-11 MESH:C106646 963084(Tax:115711) Chemical Gene CPT|conj|START_ENTITY CPT|amod|END_ENTITY CONCLUSIONS : Human MRP4 rendered significant resistance to cyclophosphamide , CPT , CPT-11 , SN-38 , rubitecan , and 10-OH-CPT . 16132345 4 10-OH-CPT 804,813 CPT-11 758,764 10-OH-CPT CPT-11 MESH:C106646 963084(Tax:115711) Chemical Gene CPT|appos|START_ENTITY CPT|conj|END_ENTITY In this study , we explored the resistance profiles and intracellular accumulation of a panel of CPTs including CPT , CPT-11 , SN-38 , rubitecan , and 10-hydroxy-CPT -LRB- 10-OH-CPT -RRB- in HepG2 cells with stably overexpressed human MRP4 . 16132345 15 10-OH-CPT 3010,3019 MRP4 2917,2921 10-OH-CPT MRP4 MESH:C106646 10257 Chemical Gene CPT|conj|START_ENTITY rendered|dobj|CPT rendered|nsubj|END_ENTITY CONCLUSIONS : Human MRP4 rendered significant resistance to cyclophosphamide , CPT , CPT-11 , SN-38 , rubitecan , and 10-OH-CPT . 16132345 4 10-OH-CPT 804,813 MRP4 862,866 10-OH-CPT MRP4 MESH:C106646 10257 Chemical Gene CPT|appos|START_ENTITY CPT|dep|END_ENTITY In this study , we explored the resistance profiles and intracellular accumulation of a panel of CPTs including CPT , CPT-11 , SN-38 , rubitecan , and 10-hydroxy-CPT -LRB- 10-OH-CPT -RRB- in HepG2 cells with stably overexpressed human MRP4 . 18643284 3 10OHF 460,465 C11 471,474 10OHF C11 null 51728 Chemical Gene mixtures|nmod|START_ENTITY mixtures|nmod|END_ENTITY Binary mixtures of 10OHF with C11 , a compound with the typical phase sequence among the smectic phases , show that the unusual phase sequence of 10OHF stabilizes upon mixing and that SmC * FI2 predominates over SmC * throughout the entire mixing phase diagram . 18643284 3 10OHF 585,590 C11 471,474 10OHF C11 null 51728 Chemical Gene sequence|nmod|START_ENTITY stabilizes|nsubj|sequence show|ccomp|stabilizes show|nsubj|mixtures mixtures|nmod|END_ENTITY Binary mixtures of 10OHF with C11 , a compound with the typical phase sequence among the smectic phases , show that the unusual phase sequence of 10OHF stabilizes upon mixing and that SmC * FI2 predominates over SmC * throughout the entire mixing phase diagram . 26567730 4 10-OH-NBP 864,873 P-gp 734,738 10-OH-NBP P-gp null 287115(Tax:10116) Chemical Gene 3-OH-NBP|conj|START_ENTITY received|dobj|3-OH-NBP received|parataxis|pretreated pretreated|nmod|tariquidar tariquidar|compound|END_ENTITY To evaluate the influences of major efflux transporters , rats were pretreated with the P-gp inhibitor tariquidar -LRB- 10 mg/kg , iv -RRB- and BCRP inhibitor pantoprazole -LRB- 40 mg/kg , iv -RRB- , then received 3-OH-NBP -LRB- 12 mg/kg , iv -RRB- or 10-OH-NBP -LRB- 3 mg/kg , iv -RRB- . 8867869 1 10-OH-NT 267,275 CYP2D6 141,147 10-OH-NT CYP2D6 null 1565 Chemical Gene 10-hydroxynortriptyline|appos|START_ENTITY nortriptyline|conj|10-hydroxynortriptyline levels|nmod|nortriptyline relationship|conj|levels relationship|nmod|genotype genotype|compound|END_ENTITY The relationship between the CYP2D6 genotype and the steady state plasma levels of nortriptyline -LRB- NT -RRB- , its main active metabolite 10-hydroxynortriptyline -LRB- 10-OH-NT -RRB- and the NT/10-OH-NT ratio were studied in 21 Caucasian depressed patients treated with 100-150 mg NT daily . 9358338 5 10-OHODA 751,759 CO2 922,925 10-OHODA CO2 null 717 Chemical Gene presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|conj|extracted extracted|nsubjpass|END_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 9358338 5 10-OHODA 936,944 CO2 922,925 10-OHODA CO2 null 717 Chemical Gene END_ENTITY|nmod|START_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 9358338 5 10-OHODA 751,759 phospholipase_A2 1035,1051 10-OHODA phospholipase A2 null 5319 Chemical Gene presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|conj|extracted extracted|nmod|macrophages macrophages|nmod|diethylether diethylether|nmod|treatment treatment|amod|END_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 9358338 5 10-OHODA 936,944 phospholipase_A2 1035,1051 10-OHODA phospholipase A2 null 5319 Chemical Gene CO2|nmod|START_ENTITY extracted|nsubjpass|CO2 extracted|nmod|macrophages macrophages|nmod|diethylether diethylether|nmod|treatment treatment|amod|END_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 9358338 5 10-OHODA 751,759 THP-1 831,836 10-OHODA THP-1 null 2736 Chemical Gene presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|nsubjpass|macrophages macrophages|acl|derived derived|nmod|END_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 9358338 5 10-OHODA 936,944 THP-1 831,836 10-OHODA THP-1 null 2736 Chemical Gene CO2|nmod|START_ENTITY extracted|nsubjpass|CO2 exposed|conj|extracted exposed|nsubjpass|macrophages macrophages|acl|derived derived|nmod|END_ENTITY In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment . 26305953 10 10-OPEA 1807,1814 cystatin-9 1959,1969 10-OPEA cystatin-9 null 732826(Tax:4577) Chemical Gene application|nummod|START_ENTITY promotes|nsubj|application promotes|dobj|activation activation|acl:relcl|inhibited inhibited|nmod|overexpression overexpression|nmod|inhibitor inhibitor|amod|END_ENTITY Consistent with a role in dying tissue , 10-OPEA application promotes cysteine protease activation and cell death , which is inhibited by overexpression of the cysteine protease inhibitor maize cystatin-9 . 6421328 1 10-O-p-toluenesulfonyldecane-1-O-phosphocholine 142,189 phospholipase_A2 87,103 10-O-p-toluenesulfonyldecane-1-O-phosphocholine phospholipase A2 MESH:D013481 29526(Tax:10116) Chemical Gene reacting|xcomp|START_ENTITY prepared|advcl|reacting prepared|nsubjpass|adsorbent adsorbent|nmod|END_ENTITY An affinity adsorbent for phospholipase_A2 -LRB- EC 3.1.1.4 -RRB- was prepared by reacting 10-O-p-toluenesulfonyldecane-1-O-phosphocholine with AH-Sepharose_4B . 12743168 2 10-O-succinoylryanodol 447,469 RyR 489,492 10-O-succinoylryanodol RyR MESH:C481699 6261 Chemical Gene START_ENTITY|nmod|END_ENTITY As is the case for all ryanoids so far examined , the interaction of 10-O-succinoylryanodol with an individual RyR channel produces profound alterations in both channel gating and rates of ion translocation . 12743168 4 10-O-succinoylryanodol 887,909 RyR 864,867 10-O-succinoylryanodol RyR MESH:C481699 6261 Chemical Gene presence|nmod|START_ENTITY observe|nmod|presence observe|dobj|range range|nmod|states states|nmod|END_ENTITY Unlike the majority of ryanoids , we observe a range of different fractional conductance states of RyR in the presence of 10-O-succinoylryanodol . 12743168 5 10-O-succinoylryanodol 931,953 RyR 1119,1122 10-O-succinoylryanodol RyR MESH:C481699 6261 Chemical Gene molecule|nsubj|START_ENTITY demonstrate|ccomp|molecule demonstrate|conj|propose propose|ccomp|arises arises|nmod|interaction interaction|nmod|conformer conformer|nmod|molecule molecule|nmod|channel channel|compound|END_ENTITY We demonstrate that 10-O-succinoylryanodol is a very flexible molecule and propose that each fractional conductance state arises from the interaction of a different conformer of the ryanoid molecule with the RyR channel . 6838824 1 10-oxide 253,261 glutathione_S-transferase 119,144 10-oxide glutathione S-transferase null 58962(Tax:10116) Chemical Gene catalyze|xcomp|START_ENTITY catalyze|nsubj|Three Three|nmod|isozymes isozymes|nmod|END_ENTITY Three of the isozymes of glutathione_S-transferase -LRB- EC 2.5.1.18 -RRB- from rat liver -LRB- isozymes A , B , and C -RRB- catalyze the addition of glutathione to phenanthrene 9 , 10-oxide with varying degrees of efficiency and stereoselectivity . 3558412 0 10-oxirane 44,54 P-450 35,40 10-oxirane P-450 null 1555 Chemical Gene androgens|amod|START_ENTITY cytochrome|nmod|androgens cytochrome|dobj|END_ENTITY Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens . 3558412 6 10-oxirane 1093,1103 P-450arom 987,996 10-oxirane P-450arom null 1588 Chemical Gene nm|dep|START_ENTITY shifts|nmod|nm showed|ccomp|shifts showed|nsubj|titrations titrations|nmod|preparations preparations|conj|END_ENTITY Spectral titrations of microsomal preparations and purified P-450arom showed that binding of the 19R-isomers shifts the Soret maximum of the ferric enzyme to 411 nm -LRB- 10-oxirane -RRB- or 425 nm -LRB- 10-thiirane -RRB- ; addition of excess androstenedione reversed the spectral changes , producing the high spin form of the enzyme with a Soret peak at 393 nm . 27392685 2 10-oxo 466,472 to_1_and_2 437,447 10-oxo to 1 and 2 null 109748(Tax:10090) Chemical Gene moieties|amod|START_ENTITY important|nsubj|moieties suggests|ccomp|important suggests|nsubj|END_ENTITY Bioassay results of various compounds related to_1_and_2 suggests that the 10-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity . 2831435 1 10-oxo-19-nor-vitamin_D3 125,149 25-OH-10-oxo-D3 208,223 10-oxo-19-nor-vitamin D3 25-OH-10-oxo-D3 null 1735 Chemical Gene START_ENTITY|conj|5 5|amod|25-hydroxy-10-oxo-19-nor-vitamin_D3 25-hydroxy-10-oxo-19-nor-vitamin_D3|dep|END_ENTITY Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively . 2831435 1 10-oxo-19-nor-vitamin_D3 125,149 D3 263,265 10-oxo-19-nor-vitamin D3 D3 null 1735 Chemical Gene START_ENTITY|dep|products products|nmod|vitamin_D3 vitamin_D3|appos|END_ENTITY Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively . 18447385 0 10-oxocembranoids 35,52 C-3 2,5 10-oxocembranoids C-3 null 718 Chemical Gene isocembranoid|conj|START_ENTITY methylated|xcomp|isocembranoid methylated|nsubj|END_ENTITY A C-3 methylated isocembranoid and 10-oxocembranoids from a formosan soft coral , Sinularia grandilobata . 18447385 2 10-oxocembranoids 399,416 C-3 343,346 10-oxocembranoids C-3 null 718 Chemical Gene identified|nmod|START_ENTITY have|advcl|identified have|nmod|group group|nmod|cembranoid cembranoid|acl|rearranged rearranged|nmod|END_ENTITY Grandilobatin_C -LRB- 3 -RRB- was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3 , while the other metabolites were identified as new 10-oxocembranoids . 18447385 2 10-oxocembranoids 399,416 C-4 287,290 10-oxocembranoids C-4 null 720 Chemical Gene identified|nmod|START_ENTITY have|advcl|identified have|nmod|group group|compound|END_ENTITY Grandilobatin_C -LRB- 3 -RRB- was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3 , while the other metabolites were identified as new 10-oxocembranoids . 2831435 1 10-oxo-D3 151,160 25-OH-10-oxo-D3 208,223 10-oxo-D3 25-OH-10-oxo-D3 null 1735 Chemical Gene 10-oxo-19-nor-vitamin_D3|dep|START_ENTITY 10-oxo-19-nor-vitamin_D3|conj|5 5|amod|25-hydroxy-10-oxo-19-nor-vitamin_D3 25-hydroxy-10-oxo-19-nor-vitamin_D3|dep|END_ENTITY Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively . 2831435 5 10-oxo-D3 597,606 25-OH-10-oxo-D3 611,626 10-oxo-D3 25-OH-10-oxo-D3 null 1735 Chemical Gene START_ENTITY|conj|END_ENTITY In addition , both 10-oxo-D3 and 25-OH-10-oxo-D3 showed poor affinities for either the plasma D3-binding protein or the thymus 1,25-dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- receptor . 2831435 1 10-oxo-D3 151,160 D3 263,265 10-oxo-D3 D3 null 1735 Chemical Gene 10-oxo-19-nor-vitamin_D3|dep|START_ENTITY 10-oxo-19-nor-vitamin_D3|dep|products products|nmod|vitamin_D3 vitamin_D3|appos|END_ENTITY Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively . 2831435 2 10-oxo-D3 357,366 D3 420,422 10-oxo-D3 D3 null 1735 Chemical Gene isomers|advcl|START_ENTITY 5|amod|isomers 40|nsubj|5 40|conj|80-fold 80-fold|amod|active active|nmod|END_ENTITY The 5 -LRB- Z -RRB- and 5 -LRB- E -RRB- isomers of 10-oxo-D3 were , respectively , 40 - and 80-fold less active than D3 in stimulating Ca +2 absorption from the gut . 2831435 5 10-oxo-D3 597,606 D3 727,729 10-oxo-D3 D3 null 1735 Chemical Gene showed|nsubj|START_ENTITY showed|nmod|protein protein|conj|receptor receptor|compound|END_ENTITY In addition , both 10-oxo-D3 and 25-OH-10-oxo-D3 showed poor affinities for either the plasma D3-binding protein or the thymus 1,25-dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- receptor . 25883 2 10-oxooctadecanoate 387,406 B3266 122,127 10-oxooctadecanoate B3266 null 947768(Tax:511145) Chemical Gene production|nmod|START_ENTITY catalyzed|dobj|production dehydrogenase|acl:relcl|catalyzed induction|conj|dehydrogenase resulted|nmod|induction resulted|nsubj|END_ENTITY NRRL B3266 in the presence of oleic_acid resulted in the induction of two enzymes : oleate hydratase , which produced 10 -LRB- R -RRB- hydroxyoctadecanoate , and hydroxyoctadecanoate dehydrogenase , which catalyzed the oxidized nicotinamide_adenine_dinucleotide-dependent production of 10-oxooctadecanoate . 18780387 3 10-oxo-PEA 717,727 LeAOS3 633,639 10-oxo-PEA LeAOS3 null 101247264 Chemical Gene cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid|dep|START_ENTITY alpha-ketol|conj|cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid became|nsubj|alpha-ketol performed|advcl|became performed|nmod|amounts amounts|nmod|END_ENTITY In contrast , the relative yield of 9,10-EOD progressively decreased when the incubations were performed with fourfold , tenfold , or 80-fold larger amounts of LeAOS3 , while alpha-ketol and the cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid -LRB- 10-oxo-PEA -RRB- became the predominant products . 18780387 4 10-oxo-PEA 787,797 LeAOS3 822,828 10-oxo-PEA LeAOS3 null 101247264 Chemical Gene alpha-ketol|conj|START_ENTITY produced|nsubjpass|alpha-ketol produced|advcl|exposed exposed|nsubjpass|END_ENTITY Both the alpha-ketol and 10-oxo-PEA were also produced when LeAOS3 was exposed to preformed 9,10-EOD , which was generated by maize allene_oxide synthase -LRB- CYP74A -RRB- . 27816594 2 10-perylene_tetracarboxylic_acid 340,372 AAT 457,460 10-perylene tetracarboxylic acid AAT null 5265 Chemical Gene nanotubes|amod|START_ENTITY 3|conj|nanotubes 3|dep|silver silver|compound|END_ENTITY The biosensor was composed of 3 , 4 , 9 , 10-perylene_tetracarboxylic_acid / carbon nanotubes -LRB- PTCA-CNTs -RRB- as a sensing platform and alkaline phosphatase-labeled AAT antibody functionalized silver nanoparticles -LRB- ALP-AAT Ab-Ag NPs -RRB- as a signal enhancer . 15297453 6 10-phenylbiliverdin_IXalpha 821,848 hHO-1 710,715 10-phenylbiliverdin IXalpha hHO-1 MESH:C032608 3162 Chemical Gene give|xcomp|START_ENTITY position|acl|give 15-phenylheme|nmod|position 15-phenylheme|dep|cleaves cleaves|amod|END_ENTITY We report here that hHO-1 cleaves 5-phenylheme to biliverdin_IXalpha and oxidizes 15-phenylheme at the alpha-meso position to give 10-phenylbiliverdin_IXalpha . 23606933 4 10-propargyl_10-deazaaminopterin 615,647 folylpolyglutamate_synthetase 774,803 10-propargyl 10-deazaaminopterin folylpolyglutamate synthetase MESH:C418863 2356 Chemical Gene Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|conj|END_ENTITY Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- . 23606933 4 10-propargyl_10-deazaaminopterin 615,647 FPGS 805,809 10-propargyl 10-deazaaminopterin FPGS MESH:C418863 2356 Chemical Gene Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|appos|END_ENTITY Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- . 23606933 4 10-propargyl_10-deazaaminopterin 615,647 reduced_folate_receptor 736,759 10-propargyl 10-deazaaminopterin reduced folate receptor MESH:C418863 6573 Chemical Gene Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|END_ENTITY Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- . 23606933 4 10-propargyl_10-deazaaminopterin 615,647 RFC 761,764 10-propargyl 10-deazaaminopterin RFC MESH:C418863 6573 Chemical Gene Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|appos|END_ENTITY Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- . 20501616 1 10-propargyl-10-deazaaminopterin 156,188 RFC-1 307,312 10-propargyl-10-deazaaminopterin RFC-1 MESH:C418863 5981 Chemical Gene Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|nmod|uptake uptake|conj|retention retention|amod|due due|nmod|affinity affinity|nmod|carrier carrier|appos|END_ENTITY PURPOSE : Pralatrexate -LRB- 10-propargyl-10-deazaaminopterin -RRB- is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier -LRB- RFC-1 -RRB- and folyl-polyglutamyl synthase . 8600835 10 10-pyrenedecanoic_acid 1944,1966 sPLA2 1899,1904 10-pyrenedecanoic acid sPLA2 null 5320 Chemical Gene trap|nmod|START_ENTITY provide|dobj|trap composed|conj|provide composed|nmod|excess excess|nmod|vesicles vesicles|acl:relcl|bind bind|dobj|END_ENTITY The latter is composed of phosphatidylcholine vesicles , in excess of substrate vesicles , which do not bind sPLA2 but provide a trap for enzyme-produced 10-pyrenedecanoic_acid . 21054397 2 10-pyrene_phosphatidylcholine 374,403 PLA 278,281 10-pyrene phosphatidylcholine PLA null 27281(Tax:10090) Chemical Gene arachidonyl_phosphatidylcholine|conj|START_ENTITY C|amod|arachidonyl_phosphatidylcholine activity|dep|C activity|compound|END_ENTITY METHODS : We measured arachidonic_acid release in -LSB- H -RSB- arachidonic_acid-labelled Raw 264.7 cells and PLA activity using 1-palmitoyl-2 - -LSB- _____ C -RSB- arachidonyl_phosphatidylcholine -LRB- -LSB- C -RSB- AA-PC -RRB- and 10-pyrene_phosphatidylcholine in vitro . 9142863 11 10-pyrene_phosphatidylcholine 1467,1496 PLA2 1385,1389 10-pyrene phosphatidylcholine PLA2 MESH:C033518 5319 Chemical Gene signal|nmod|START_ENTITY slope|nmod|signal reflected|nmod|slope increased|advcl|reflected increased|dobj|activity activity|compound|END_ENTITY Ca/CaM also increased PLA2 activity , as reflected by an increase in the slope of fluorescence signal of 10-pyrene_phosphatidylcholine , a substrate for PLA2 . 9142863 11 10-pyrene_phosphatidylcholine 1467,1496 PLA2 1514,1518 10-pyrene phosphatidylcholine PLA2 MESH:C033518 5319 Chemical Gene START_ENTITY|appos|substrate substrate|nmod|END_ENTITY Ca/CaM also increased PLA2 activity , as reflected by an increase in the slope of fluorescence signal of 10-pyrene_phosphatidylcholine , a substrate for PLA2 . 2742139 1 10-pyrenyldecanoic_acid 289,312 Phospholipase_A2 136,152 10-pyrenyldecanoic acid Phospholipase A2 MESH:C052091 5319 Chemical Gene position|nmod|START_ENTITY labeled|nmod|position phospholipids|acl|labeled using|dobj|phospholipids determined|xcomp|using determined|nsubjpass|activity activity|amod|END_ENTITY Phospholipase_A2 activity can be determined fluorometrically in the presence of serum_albumin using phospholipids labeled at the sn-2-acyl position with 10-pyrenyldecanoic_acid . 2742139 1 10-pyrenyldecanoic_acid 289,312 serum_albumin 216,229 10-pyrenyldecanoic acid serum albumin MESH:C052091 213 Chemical Gene position|nmod|START_ENTITY labeled|nmod|position phospholipids|acl|labeled using|dobj|phospholipids determined|xcomp|using determined|nmod|presence presence|nmod|END_ENTITY Phospholipase_A2 activity can be determined fluorometrically in the presence of serum_albumin using phospholipids labeled at the sn-2-acyl position with 10-pyrenyldecanoic_acid . 9443042 0 10q22-23 84,92 PTEN 156,160 10q22-23 PTEN MESH:D064532 5728 Chemical Gene locus|advcl|START_ENTITY imbalance|amod|locus imbalance|nmod|Cowden_syndrome Cowden_syndrome|conj|mutation mutation|compound|END_ENTITY Allelic imbalance , including deletion of PTEN/MMACI , at the Cowden_disease locus on 10q22-23 , in hamartomas from patients with Cowden_syndrome and germline PTEN mutation . 26300167 1 10R-germacradienyl 700,718 C-10 685,689 10R-germacradienyl C-10 null 3226 Chemical Gene cation|amod|START_ENTITY form|dobj|cation FPP|acl|form FPP|nmod|si-face si-face|nmod|END_ENTITY The absolute configurations of kelsoene and prespatane thus determined suggest that initial cyclization of FPP from the si-face at C-10 to form a 10R-germacradienyl cation leads to kelsoene , while that from the re-face leads to prespatane via the 10S-germacradienyl cation . 6181401 0 10S 28,31 acetylcholinesterase 32,52 10S acetylcholinesterase null 11423(Tax:10090) Chemical Gene transport|nmod|START_ENTITY END_ENTITY|nsubj|transport Reduced axonal transport of 10S acetylcholinesterase in dystrophic mice . 16424216 6 10S,17S-diHDHA 1308,1322 PD1 1427,1430 10S,17S-diHDHA PD1 null 6139 Chemical Gene carried|nsubj|START_ENTITY carried|advcl|proceeded proceeded|nsubj|formation formation|compound|END_ENTITY 18O2 labeling showed that 10S,17S-diHDHA -LRB- isomer I -RRB- carried 18O in the carbon-10 position alcohol , indicating sequential lipoxygenation , whereas PD1 formation proceeded via an epoxide . 16424216 9 10S,17S-diHDHA 1819,1833 PD1 1762,1765 10S,17S-diHDHA PD1 null 6139 Chemical Gene Delta15-trans-PD1|amod|START_ENTITY END_ENTITY|dobj|Delta15-trans-PD1 The rank order at 1 - to 10-ng dose was PD1 approximately PD1_methyl_ester > Delta15-trans-PD1 > 10S,17S-diHDHA -LRB- isomer I -RRB- . 26300167 1 10S-germacradienyl 801,819 C-10 685,689 10S-germacradienyl C-10 null 3226 Chemical Gene cation|amod|START_ENTITY prespatane|nmod|cation leads|xcomp|prespatane leads|advcl|leads leads|nsubj|cyclization cyclization|nmod|FPP FPP|nmod|si-face si-face|nmod|END_ENTITY The absolute configurations of kelsoene and prespatane thus determined suggest that initial cyclization of FPP from the si-face at C-10 to form a 10R-germacradienyl cation leads to kelsoene , while that from the re-face leads to prespatane via the 10S-germacradienyl cation . 20837112 2 10-shogaol 363,373 COX-2 307,312 10-shogaol COX-2 MESH:C585130 4513 Chemical Gene bound|conj|START_ENTITY roots|conj|bound roots|nmod|ligands ligands|compound|END_ENTITY Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands , and 10-gingerol , 12-gingerol , 8-shogaol , 10-shogaol , 6-gingerdione , 8-gingerdione , 10-gingerdione , 6-dehydro-10-gingerol , 6-paradol , and 8-paradol bound to the enzyme active site . 28872603 9 10-shogaol 1208,1218 GST 1298,1301 10-shogaol GST MESH:C585130 373156 Chemical Gene 6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|MRP1 MRP1|conj|END_ENTITY Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression . 28872603 9 10-shogaol 1208,1218 MRP1 1289,1293 10-shogaol MRP1 MESH:C585130 4363 Chemical Gene 6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression . 28872603 6 10-shogaol 770,780 PC3 934,937 10-shogaol PC3 MESH:C585130 5122 Chemical Gene 10-gingerol|conj|START_ENTITY M|amod|10-gingerol inhibited|nsubj|M inhibited|ccomp|displayed displayed|nmod|END_ENTITY 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 . 28872603 6 10-shogaol 893,903 PC3 934,937 10-shogaol PC3 MESH:C585130 5122 Chemical Gene PC3R|conj|START_ENTITY proliferation|acl|PC3R displayed|nsubj|proliferation displayed|nmod|END_ENTITY 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 . 22408422 3 10-Shogaol 410,420 TGF-b 488,493 10-Shogaol TGF-b null 7040 Chemical Gene production|amod|START_ENTITY production|nmod|transforming_growth_factor-b transforming_growth_factor-b|appos|END_ENTITY 10-Shogaol enhanced growth factor production in transforming_growth_factor-b -LRB- TGF-b -RRB- , platelet derived growth factor-ab -LRB- PDGF-ab -RRB- and vascular endothelial growth factors -LRB- VEGF -RRB- of both cells . 22408422 3 10-Shogaol 410,420 transforming_growth_factor-b 458,486 10-Shogaol transforming growth factor-b null 7040 Chemical Gene production|amod|START_ENTITY production|nmod|END_ENTITY 10-Shogaol enhanced growth factor production in transforming_growth_factor-b -LRB- TGF-b -RRB- , platelet derived growth factor-ab -LRB- PDGF-ab -RRB- and vascular endothelial growth factors -LRB- VEGF -RRB- of both cells . 16905316 1 10S-hydroxylobel-7-ene 505,527 DAT 584,587 10S-hydroxylobel-7-ene DAT null 6531 Chemical Gene 3c|amod|START_ENTITY 8R-hydroxylobel-9-ene|conj|3c exhibited|nsubj|8R-hydroxylobel-9-ene exhibited|nmod|SERT SERT|conj|END_ENTITY The enantiomers 8R-hydroxylobel-9-ene -LRB- 3a -RRB- and 10S-hydroxylobel-7-ene -LRB- 3c -RRB- exhibited high potency and selectivity at SERT and DAT , respectively . 16905316 1 10S-hydroxylobel-7-ene 505,527 SERT 575,579 10S-hydroxylobel-7-ene SERT null 6532 Chemical Gene 3c|amod|START_ENTITY 8R-hydroxylobel-9-ene|conj|3c exhibited|nsubj|8R-hydroxylobel-9-ene exhibited|nmod|END_ENTITY The enantiomers 8R-hydroxylobel-9-ene -LRB- 3a -RRB- and 10S-hydroxylobel-7-ene -LRB- 3c -RRB- exhibited high potency and selectivity at SERT and DAT , respectively . 27255290 0 10-substituted-2-morpholino-chromen-oxazine-dione 109,158 DNA-PK 34,40 10-substituted-2-morpholino-chromen-oxazine-dione DNA-PK null 5591 Chemical Gene Synthesis|conj|START_ENTITY Synthesis|conj|activity activity|compound|END_ENTITY Synthesis , structure elucidation , DNA-PK , PI3K , anti-platelet and anti-bacteria activity of linear 5 , 6 , and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3 , _ 4 , _ 6-substituted-8-morpholino-chromen-oxazine-2 ,10 - dione . 27255290 0 10-substituted-2-morpholino-chromen-oxazine-dione 109,158 PI3K 42,46 10-substituted-2-morpholino-chromen-oxazine-dione PI3K null 5293 Chemical Gene Synthesis|conj|START_ENTITY Synthesis|conj|activity activity|compound|DNA-PK DNA-PK|conj|END_ENTITY Synthesis , structure elucidation , DNA-PK , PI3K , anti-platelet and anti-bacteria activity of linear 5 , 6 , and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3 , _ 4 , _ 6-substituted-8-morpholino-chromen-oxazine-2 ,10 - dione . 12808237 0 10-thiaisoalloxazines 43,64 C-5 89,92 10-thiaisoalloxazines C-5 null 727 Chemical Gene activity|nmod|START_ENTITY Synthesis|conj|activity Synthesis|appos|analog analog|nmod|C-6 C-6|compound|END_ENTITY Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines , a structural analog of C-5 and/or C-6 substituted pyrimidine_acyclonucleoside . 12808237 0 10-thiaisoalloxazines 43,64 C-6 100,103 10-thiaisoalloxazines C-6 null 729 Chemical Gene activity|nmod|START_ENTITY Synthesis|conj|activity Synthesis|appos|analog analog|nmod|END_ENTITY Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines , a structural analog of C-5 and/or C-6 substituted pyrimidine_acyclonucleoside . 3558412 0 10-thiirane 59,70 P-450 35,40 10-thiirane P-450 null 1555 Chemical Gene 10-oxirane|conj|START_ENTITY androgens|amod|10-oxirane cytochrome|nmod|androgens cytochrome|dobj|END_ENTITY Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens . 3558412 6 10-thiirane 1116,1127 P-450arom 987,996 10-thiirane P-450arom null 1588 Chemical Gene nm|dep|START_ENTITY shifts|nmod|nm showed|ccomp|shifts showed|nsubj|titrations titrations|nmod|preparations preparations|conj|END_ENTITY Spectral titrations of microsomal preparations and purified P-450arom showed that binding of the 19R-isomers shifts the Soret maximum of the ferric enzyme to 411 nm -LRB- 10-oxirane -RRB- or 425 nm -LRB- 10-thiirane -RRB- ; addition of excess androstenedione reversed the spectral changes , producing the high spin form of the enzyme with a Soret peak at 393 nm . 27902770 10 10-TPP 1644,1650 caspase_3 1704,1713 10-TPP caspase 3 null 836 Chemical Gene 2-DG|conj|START_ENTITY Relative|nmod|2-DG showed|ccomp|Relative showed|dobj|activation activation|amod|END_ENTITY Relative to 2-DG or 10-TPP alone , 2-DG plus 10-TPP combination showed increased caspase_3 activation in MM cells with minimal toxicity to the normal hematopoietic progenitor cells . 27902770 10 10-TPP 1668,1674 caspase_3 1704,1713 10-TPP caspase 3 null 836 Chemical Gene combination|nummod|START_ENTITY 2-DG|nmod|combination showed|nsubj|2-DG showed|dobj|activation activation|amod|END_ENTITY Relative to 2-DG or 10-TPP alone , 2-DG plus 10-TPP combination showed increased caspase_3 activation in MM cells with minimal toxicity to the normal hematopoietic progenitor cells . 9916876 2 10-tridecyl_ether 327,344 PLP 266,269 10-tridecyl ether PLP MESH:C117129 24943(Tax:10116) Chemical Gene solution|nmod|START_ENTITY water|conj|solution solubilized|nmod|water solubilized|nsubjpass|END_ENTITY PLP was solubilized in water or in an aqueous solution of 1 % 10-tridecyl_ether -LRB- TDE -RRB- , a non-ionic detergent used in membrane protein research . 10423286 1 10-undecenoate/p-methylbenzoate 636,667 CSP-1 730,735 10-undecenoate/p-methylbenzoate CSP-1 null 1827 Chemical Gene amylose|conj|START_ENTITY 10-undecenoate/3|nmod|amylose derivatives|nsubj|10-undecenoate/3 derivatives|nmod|END_ENTITY The mixed 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of cellulose , _ 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of amylose and 10-undecenoate/p-methylbenzoate of cellulose were the starting polysaccharide derivatives for CSP-1 , CSP-2 , and CSP-3 , respectively . 10423286 1 10-undecenoate/p-methylbenzoate 636,667 CSP-2 737,742 10-undecenoate/p-methylbenzoate CSP-2 null 10231 Chemical Gene amylose|conj|START_ENTITY 10-undecenoate/3|nmod|amylose derivatives|nsubj|10-undecenoate/3 derivatives|nmod|CSP-1 CSP-1|conj|END_ENTITY The mixed 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of cellulose , _ 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of amylose and 10-undecenoate/p-methylbenzoate of cellulose were the starting polysaccharide derivatives for CSP-1 , CSP-2 , and CSP-3 , respectively . 8337229 5 10-undecynoic_acid 981,999 CYP2E 821,826 10-undecynoic acid CYP2E MESH:C048289 25086(Tax:10116) Chemical Gene effect|advcl|START_ENTITY effect|nsubj|inducer inducer|compound|END_ENTITY The CYP2E inducer , isoniazid and the CYP2E inhibitor , diallyl_sulfide were virtually without effect , as was the CYP4A inducer , clofibrate , and the CYP4A inhibitor , 10-undecynoic_acid . 8337229 5 10-undecynoic_acid 981,999 CYP2E 854,859 10-undecynoic acid CYP2E MESH:C048289 25086(Tax:10116) Chemical Gene effect|advcl|START_ENTITY effect|nsubj|inducer inducer|appos|isoniazid isoniazid|conj|inhibitor inhibitor|compound|END_ENTITY The CYP2E inducer , isoniazid and the CYP2E inhibitor , diallyl_sulfide were virtually without effect , as was the CYP4A inducer , clofibrate , and the CYP4A inhibitor , 10-undecynoic_acid . 10453996 2 10-undecynoic_acid 455,473 cytochrome_P450_4A1 541,560 10-undecynoic acid cytochrome P450 4A1 MESH:C048289 50549(Tax:10116) Chemical Gene rats|nmod|START_ENTITY administration|nmod|rats administration|appos|inhibitor inhibitor|nmod|reaction reaction|acl|catalyzed catalyzed|nmod|END_ENTITY On the other hand , administration to rats of 10-undecynoic_acid , a specific inhibitor of omega-hydroxylation reaction catalyzed by cytochrome_P450_4A1 , inhibits the ethanolamine-specific phospholipid base exchange activity by 30 % . 8486647 6 10-undecynoic_acid 1206,1224 L-FABP 1009,1015 10-undecynoic acid L-FABP MESH:C048289 2168 Chemical Gene 1-aminobenzotriazole|conj|START_ENTITY pretranslationally|advcl|1-aminobenzotriazole pretranslationally|nsubj|increases increases|nmod|beta-oxidation beta-oxidation|conj|END_ENTITY The CF-mediated increases in peroxisomal beta-oxidation and L-FABP , but not P-450IVA1 , could be significantly inhibited pretranslationally by concurrent exposure of cultured hepatocytes to inactivators of cytochromes P-450 , such as 1-aminobenzotriazole and 10-undecynoic_acid . 10453996 0 10-Undecynoic_acid 0,18 cytochrome_P450_4A1 36,55 10-Undecynoic acid cytochrome P450 4A1 MESH:C048289 50549(Tax:10116) Chemical Gene START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY 10-Undecynoic_acid , an inhibitor of cytochrome_P450_4A1 , inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes . 9470175 4 10-Undecynoic_acid 872,890 lipase 960,966 10-Undecynoic acid lipase MESH:C048289 26302740 Chemical Gene gave|nsubj|START_ENTITY gave|nmod|kind kind|nmod|END_ENTITY 10-Undecynoic_acid gave the highest conversion rate of esterification with each kind of lipase used . 15720395 1 110-124 317,324 phospholipase_A2 164,180 110-124 phospholipase A2 MESH:C448907 100347180(Tax:9986) Chemical Gene residues|nummod|START_ENTITY C-terminus|appos|residues variable|nsubj|C-terminus shows|ccomp|variable shows|nsubj|Comparison Comparison|nmod|structures structures|nmod|isoenzymes isoenzymes|amod|END_ENTITY Comparison of the crystal structures of three Micropechis ikaheka phospholipase_A2 isoenzymes -LRB- MiPLA2 , MiPLA3 and MiPLA4 , which exhibit different levels of pharmacological effects -RRB- shows that their C-terminus -LRB- residues 110-124 -RRB- is the most variable . 9685376 4 1103-amino_acid 617,632 KIF1C 641,646 1103-amino acid KIF1C MESH:C000596773 16562(Tax:10090) Chemical Gene END_ENTITY|amod|START_ENTITY Like its homologues , the 1103-amino_acid protein KIF1C consists of an amino-terminal motor domain followed by a U104_domain and probably binds to target membranes through carboxyl-terminal sequences . 20515953 3 1-104_amino_acids 651,668 IGF-II 643,649 1-104 amino acids IGF-II null 3481 Chemical Gene END_ENTITY|dep|START_ENTITY Using a Fab-displaying phage library and a biotinylated precursor form of IGF-II -LRB- 1-104_amino_acids -RRB- as a target , we isolated Fabs specific for the E-domain COOH-terminal extension form of IGF-II and for mature IGF-II . 20515953 3 1-104_amino_acids 651,668 IGF-II 780,786 1-104 amino acids IGF-II null 3481 Chemical Gene IGF-II|dep|START_ENTITY form|nmod|IGF-II library|conj|form Using|dobj|library isolated|advcl|Using isolated|nmod|form form|conj|END_ENTITY Using a Fab-displaying phage library and a biotinylated precursor form of IGF-II -LRB- 1-104_amino_acids -RRB- as a target , we isolated Fabs specific for the E-domain COOH-terminal extension form of IGF-II and for mature IGF-II . 9346957 6 110-amino_acid 1166,1180 Shc 1079,1082 110-amino acid Shc MESH:C005842 6464 Chemical Gene extension|amod|START_ENTITY generating|dobj|extension resulted|xcomp|generating resulted|nsubj|cDNA cDNA|compound|END_ENTITY Sequence alignment confirmed that the 66-kDa Shc cDNA resulted from alternative splicing of the primary Shc transcript generating a 110-amino_acid extension at the amino terminus . 9346957 6 110-amino_acid 1166,1180 Shc 1138,1141 110-amino acid Shc MESH:C005842 6464 Chemical Gene extension|amod|START_ENTITY generating|dobj|extension resulted|xcomp|generating resulted|nmod|splicing splicing|nmod|transcript transcript|compound|END_ENTITY Sequence alignment confirmed that the 66-kDa Shc cDNA resulted from alternative splicing of the primary Shc transcript generating a 110-amino_acid extension at the amino terminus . 8083230 5 110-amino-acid 786,800 cPLA2 769,774 110-amino-acid cPLA2 MESH:C005842 5321 Chemical Gene region|amod|START_ENTITY contains|dobj|region contains|nsubj|END_ENTITY We noted that cPLA2 contains a 110-amino-acid region with sequence homology to phospholipase B -LRB- PLB -RRB- from Penicillium_notatum . 8083230 5 110-amino-acid 786,800 PLB 851,854 110-amino-acid PLB MESH:C005842 5350 Chemical Gene region|amod|START_ENTITY contains|dobj|region contains|advcl|phospholipase phospholipase|dobj|END_ENTITY We noted that cPLA2 contains a 110-amino-acid region with sequence homology to phospholipase B -LRB- PLB -RRB- from Penicillium_notatum . 11829755 10 110-amino-acid 1466,1480 Scamper 1453,1460 110-amino-acid Scamper MESH:C005842 286756 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY In contrast with what has been believed hitherto , our primary-structure and overexpression experiments indicate that Scamper is a 110-amino-acid protein spanning the membrane once with a Nexo/Ccyt topology -LSB- von_Heijne and Gavel -LRB- 1988 -RRB- Eur . 26405039 5 1,10-bisquinuclidinedecane 1284,1310 OCT1 1206,1210 1,10-bisquinuclidinedecane OCT1 null 6580 Chemical Gene 1,10-diaminodecane|conj|START_ENTITY polyamines|dep|1,10-diaminodecane polyamines|conj|blockers blockers|compound|END_ENTITY Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s . 26405039 5 1,10-bisquinuclidinedecane 1284,1310 OCT3 1327,1331 1,10-bisquinuclidinedecane OCT3 null 100049579 Chemical Gene 1,10-diaminodecane|conj|START_ENTITY polyamines|dep|1,10-diaminodecane interactions|nmod|polyamines interactions|nmod|END_ENTITY Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s . 16087391 8 1,10-DAC 1658,1666 CYP 1624,1627 1,10-DAC CYP null 4051 Chemical Gene mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|advcl|using using|nmod|cells cells|acl|expressing expressing|dobj|isoforms isoforms|compound|END_ENTITY However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC . 16087391 8 1,10-DAC 1658,1666 CYP1A2 1705,1711 1,10-DAC CYP1A2 null 1544 Chemical Gene mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|nmod|END_ENTITY However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC . 16087391 9 1,10-DAC 1831,1839 CYP1A2 1886,1892 1,10-DAC CYP1A2 null 1544 Chemical Gene shows|nsubj|START_ENTITY shows|nmod|involvement involvement|nmod|END_ENTITY These results suggest that 1,10-DAC shows the mutagenicity through involvement of CYP1A2 in human liver , and 4,10-DAC does so through both CYP2A6 and 1A2 . 16087391 8 1,10-DAC 1658,1666 CYP2A6 1744,1750 1,10-DAC CYP2A6 null 1548 Chemical Gene mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|advcl|contributed contributed|nsubj|END_ENTITY However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC . 16087391 9 1,10-DAC 1831,1839 CYP2A6 1943,1949 1,10-DAC CYP2A6 null 1548 Chemical Gene shows|nsubj|START_ENTITY suggest|ccomp|shows suggest|conj|does does|nmod|END_ENTITY These results suggest that 1,10-DAC shows the mutagenicity through involvement of CYP1A2 in human liver , and 4,10-DAC does so through both CYP2A6 and 1A2 . 15664816 4 1,10-decylene-bis-sulfamate 860,887 hCA_IX 789,795 1,10-decylene-bis-sulfamate hCA IX MESH:D001729 768 Chemical Gene 1,8-octylene-bis-sulfamate|conj|START_ENTITY detected|nmod|1,8-octylene-bis-sulfamate detected|nsubjpass|inhibitors inhibitors|compound|END_ENTITY Several low nanomolar hCA_IX inhibitors were detected , such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate -LRB- K -LRB- I -RRB- s in the range of 4-7 nM -RRB- , which showed good selectivity ratios -LRB- in the range of 3.50-3 .85 -RRB- for hCA_IX over hCA II inhibition . 15664816 4 1,10-decylene-bis-sulfamate 860,887 hCA_IX 990,996 1,10-decylene-bis-sulfamate hCA IX MESH:D001729 768 Chemical Gene 1,8-octylene-bis-sulfamate|conj|START_ENTITY 1,8-octylene-bis-sulfamate|acl:relcl|showed showed|dobj|ratios ratios|nmod|END_ENTITY Several low nanomolar hCA_IX inhibitors were detected , such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate -LRB- K -LRB- I -RRB- s in the range of 4-7 nM -RRB- , which showed good selectivity ratios -LRB- in the range of 3.50-3 .85 -RRB- for hCA_IX over hCA II inhibition . 25612558 5 1,10-diaminodecane 1107,1125 alcohol_dehydrogenase 1042,1063 1,10-diaminodecane alcohol dehydrogenase MESH:C065351 10327 Chemical Gene rate|amod|START_ENTITY improved|dobj|rate matched|conj|improved matched|dobj|dehydrogenase dehydrogenase|amod|END_ENTITY At 42 C , TaCv was more active , which matched thermostable alcohol_dehydrogenase and alanine dehydrogenase and improved the 1,10-diaminodecane production rate four-fold . 26512870 1 1,10-diaminodecane 501,519 III 577,580 1,10-diaminodecane III MESH:C065351 4514 Chemical Gene reaction|acl|START_ENTITY gave|nsubj|reaction gave|dobj|complex complex|appos|END_ENTITY The amide formation reaction of with 1,10-diaminodecane and polyallylamine gave the diamine-bridged dinuclear Rh -LRB- III -RRB- complex and the single-chain polymer-supported Rh -LRB- III -RRB- complex with retention of the L configuration of , respectively . 26405039 5 1,10-diaminodecane 1221,1239 OCT1 1206,1210 1,10-diaminodecane OCT1 MESH:C065351 6580 Chemical Gene polyamines|dep|START_ENTITY polyamines|conj|blockers blockers|compound|END_ENTITY Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s . 26405039 5 1,10-diaminodecane 1221,1239 OCT3 1327,1331 1,10-diaminodecane OCT3 MESH:C065351 100049579 Chemical Gene polyamines|dep|START_ENTITY interactions|nmod|polyamines interactions|nmod|END_ENTITY Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s . 20961817 3 1-10-nucleotide 593,608 Pol_b 572,577 1-10-nucleotide Pol b MESH:D009711 5423 Chemical Gene gaps|amod|START_ENTITY filled|dobj|gaps determined|advcl|filled determined|parataxis|proposed proposed|xcomp|support support|dobj|polymerase_b polymerase_b|appos|END_ENTITY Here , we quantitatively determined the substrate specificity and base substitution fidelity of human DNA polymerase -LRB- Pol -RRB- , an enzyme proposed to support the known BER DNA polymerase_b -LRB- Pol_b -RRB- , as it filled 1-10-nucleotide gaps at 1-nucleotide intervals . 20961817 3 1-10-nucleotide 593,608 polymerase_b 558,570 1-10-nucleotide polymerase b MESH:D009711 5423 Chemical Gene gaps|amod|START_ENTITY filled|dobj|gaps determined|advcl|filled determined|parataxis|proposed proposed|xcomp|support support|dobj|END_ENTITY Here , we quantitatively determined the substrate specificity and base substitution fidelity of human DNA polymerase -LRB- Pol -RRB- , an enzyme proposed to support the known BER DNA polymerase_b -LRB- Pol_b -RRB- , as it filled 1-10-nucleotide gaps at 1-nucleotide intervals . 3314587 2 1,10-o-phenanthroline 465,486 Fibrinogen 321,331 1,10-o-phenanthroline Fibrinogen null 2244 Chemical Gene denaturation|nmod|START_ENTITY proteolysis|conj|denaturation sensitive|dep|proteolysis sensitive|nsubj|END_ENTITY Fibrinogen is sensitive both to proteolysis by contaminants which may constitute as little as 0.2 % of the enzyme protein and to denaturation by 1,10-o-phenanthroline , the only substance known to inhibit the proteolysis . 7575672 8 1,10-O-phenanthroline 1407,1428 Aminopeptidase 1311,1325 1,10-O-phenanthroline Aminopeptidase null 10404 Chemical Gene amastatin|conj|START_ENTITY inhibited|nmod|amastatin inhibited|nsubj|activity activity|amod|END_ENTITY Aminopeptidase activity in disrupted epithelial cells was inhibited by amastatin , bestatin , and 1,10-O-phenanthroline -LRB- IC50 values of 500 nM , 1 microM , and 17 microM , respectively -RRB- , but not by captopril at the highest concentration tested , 10 mM . 1777123 4 1,10-O-phenanthroline 567,588 catalase 469,477 1,10-O-phenanthroline catalase null 847 Chemical Gene offered|nsubj|START_ENTITY observed|advcl|offered achieved|parataxis|observed achieved|nmod|inclusion inclusion|nmod|END_ENTITY Short-term protection of hemolytic activity was achieved by inclusion of catalase in the preparation ; no apparent protection was observed by superoxide dismutase , whereas 1,10-O-phenanthroline offered long-term protection of the hemolysin . 9830036 6 1,10-O-phenanthroline 799,820 lck 763,766 1,10-O-phenanthroline lck null 3932 Chemical Gene results|amod|START_ENTITY dimers|dobj|results dimers|nsubj|p56 p56|appos|END_ENTITY p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes . 7575672 7 1,10-O-phenanthroline 1227,1248 LTA4_hydrolase 1125,1139 1,10-O-phenanthroline LTA4 hydrolase null 4048 Chemical Gene revealed|conj|START_ENTITY values|amod|revealed cells|nmod|values examined|nmod|cells examined|nsubj|curves curves|amod|END_ENTITY LTA4_hydrolase concentration-inhibition curves examined in intact cells with captopril , bestatin , and 1,10-O-phenanthroline revealed IC50 values of 63 , 70 , and 920 microM , respectively . 9830036 6 1,10-O-phenanthroline 799,820 p56 759,762 1,10-O-phenanthroline p56 null 8999 Chemical Gene results|amod|START_ENTITY dimers|dobj|results dimers|nsubj|END_ENTITY p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes . 9830036 6 1,10-O-phenanthroline 799,820 p56 899,902 1,10-O-phenanthroline p56 null 8999 Chemical Gene results|amod|START_ENTITY results|nmod|dissociation dissociation|nmod|GST-CD4 GST-CD4|nmod|END_ENTITY p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes . 762062 7 1,10-orthophenanthroline 746,770 amidophosphoribosyltransferase 836,866 1,10-orthophenanthroline amidophosphoribosyltransferase null 5471 Chemical Gene Incubation|advcl|START_ENTITY Incubation|ccomp|led led|nmod|inactivation inactivation|nmod|END_ENTITY Incubation with 1,10-orthophenanthroline , but not 1,7-metaphenanthroline or tiron , led to inactivation of amidophosphoribosyltransferase . 3278222 8 1,10-orthophenanthroline 1258,1282 gp63 1341,1345 1,10-orthophenanthroline gp63 null 89782 Chemical Gene ions|conj|START_ENTITY inhibited|nsubj|ions inhibited|dobj|activity activity|nummod|END_ENTITY Among various protease inhibitors tested , only heavy metal ions -LRB- 1 mM -RRB- , 1,10-orthophenanthroline -LRB- 1 mM -RRB- and bestatin -LRB- 100 ng ml-1 -RRB- significantly inhibited gp63 acid protease activity by up to 80 % . 1280325 4 1,10-orthophenanthroline 652,676 MyTI 618,622 1,10-orthophenanthroline MyTI null 4661 Chemical Gene eliminates|nsubj|START_ENTITY cofactor|advcl|eliminates cofactor|nmod|binding binding|nmod|END_ENTITY Zinc is a necessary cofactor for DNA binding of MyTI , as the zinc-chelating agent 1,10-orthophenanthroline eliminates binding activity . 9315628 8 1,10-orthophenanthroline 1244,1268 p53 1360,1363 1,10-orthophenanthroline p53 null 7157 Chemical Gene promoted|nsubj|START_ENTITY promoted|dobj|activity activity|nmod|copper copper|conj|activity activity|compound|END_ENTITY In contrast , 1,10-orthophenanthroline , a cell-permeable chelator of Cu2 + , promoted the redox activity of copper and up-regulated p53 DNA-binding activity through a DNA damage-dependent pathway . 11882664 7 1,10-ortho-phenanthroline 1479,1504 galectin-3 1437,1447 1,10-ortho-phenanthroline galectin-3 null 3958 Chemical Gene lactose|conj|START_ENTITY inhibited|xcomp|lactose inhibited|nmod|antagonist antagonist|amod|END_ENTITY This cleavage was inhibited by the galectin-3 antagonist lactose , as well as 1,10-ortho-phenanthroline , suggesting that galectin-3 is cleaved by zinc metalloproteases after its binding to lipophosphoglycans . 11882664 7 1,10-ortho-phenanthroline 1479,1504 galectin-3 1522,1532 1,10-ortho-phenanthroline galectin-3 null 3958 Chemical Gene lactose|conj|START_ENTITY lactose|ccomp|suggesting suggesting|ccomp|cleaved cleaved|nsubjpass|END_ENTITY This cleavage was inhibited by the galectin-3 antagonist lactose , as well as 1,10-ortho-phenanthroline , suggesting that galectin-3 is cleaved by zinc metalloproteases after its binding to lipophosphoglycans . 1985897 6 1,10-orthophenantroline 677,700 NF-kappa_B 618,628 1,10-orthophenantroline NF-kappa B null 4790 Chemical Gene blocked|nmod|START_ENTITY blocked|nsubjpass|binding binding|nmod|END_ENTITY DNA binding of NF-kappa_B was specifically blocked by the chelating agent 1,10-orthophenantroline and could only be reconstituted by addition of Zn2 + . 23081896 9 1,10-PHEN 1227,1236 TIMP3 1238,1243 1,10-PHEN TIMP3 null 396775(Tax:9823) Chemical Gene Similar|nmod|START_ENTITY inhibited|advcl|Similar inhibited|nsubj|END_ENTITY Similar to 1,10-PHEN , TIMP3 inhibited total fertilization rate of CI but not CF oocytes and did not influence sperm quality parameters . 1385096 7 1,10-phenanthrolene 1729,1748 IGFBP-4 1636,1643 1,10-phenanthrolene IGFBP-4 null 3487 Chemical Gene inhibitors|conj|START_ENTITY prevented|nmod|inhibitors prevented|nsubjpass|decrease decrease|nmod|END_ENTITY The IGF-dependent decrease in IGFBP-4 was prevented by coincubation of the media with serine protease inhibitors , EDTA , or 1,10-phenanthrolene , suggesting that IGFs may activate an IGFBP-4 specific metallo-serine protease present in fibroblast conditioned media . 1385096 7 1,10-phenanthrolene 1729,1748 IGFBP-4 1787,1794 1,10-phenanthrolene IGFBP-4 null 3487 Chemical Gene inhibitors|conj|START_ENTITY prevented|nmod|inhibitors prevented|xcomp|suggesting suggesting|ccomp|activate activate|dobj|present present|compound|END_ENTITY The IGF-dependent decrease in IGFBP-4 was prevented by coincubation of the media with serine protease inhibitors , EDTA , or 1,10-phenanthrolene , suggesting that IGFs may activate an IGFBP-4 specific metallo-serine protease present in fibroblast conditioned media . 8675593 10 1,10-phenanthrolene 1795,1814 IGFBP-4 1675,1682 1,10-phenanthrolene IGFBP-4 null 3487 Chemical Gene ethylenediamine_tetraacetate|conj|START_ENTITY IGFs|dep|ethylenediamine_tetraacetate coincubation|nmod|IGFs prevented|nmod|coincubation prevented|nsubjpass|decrease decrease|nmod|concentrations concentrations|compound|END_ENTITY The decrease in IGFBP-4 concentrations was prevented by coincubation of the CM with the IGFs and either ethylenediamine_tetraacetate or 1,10-phenanthrolene , but not with other protease inhibitors . 10216093 4 1-10-phenanthroline 789,808 PAI-1 859,864 1-10-phenanthroline PAI-1 MESH:C025205 5054 Chemical Gene chelators|nmod|START_ENTITY chelators|conj|plasminogen_activator_inhibitor-1 plasminogen_activator_inhibitor-1|appos|END_ENTITY Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR . 10216093 4 1-10-phenanthroline 789,808 plasminogen_activator_inhibitor-1 824,857 1-10-phenanthroline plasminogen activator inhibitor-1 MESH:C025205 5054 Chemical Gene chelators|nmod|START_ENTITY chelators|conj|END_ENTITY Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR . 10216093 4 1-10-phenanthroline 789,808 uPAR 907,911 1-10-phenanthroline uPAR MESH:C025205 5329 Chemical Gene chelators|nmod|START_ENTITY abolished|nmod|chelators abolished|nmod|END_ENTITY Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR . 10216093 4 1-10-phenanthroline 789,808 VN 744,746 1-10-phenanthroline VN MESH:C025205 7448 Chemical Gene chelators|nmod|START_ENTITY abolished|nmod|chelators abolished|nsubjpass|adhesion adhesion|nmod|END_ENTITY Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR . 2559080 5 1,10-phenanthroline 905,924 3_alpha-hydroxysteroid_dehydrogenase 941,977 1,10-phenanthroline 3 alpha-hydroxysteroid dehydrogenase MESH:C025205 8644 Chemical Gene inhibitor|amod|START_ENTITY suppressed|nsubj|inhibitor suppressed|dobj|activity activity|amod|END_ENTITY The specific inhibitor of the enzyme , 1,10-phenanthroline , suppressed the 3_alpha-hydroxysteroid_dehydrogenase activity in the crude extract of monkey liver by 50 % . 9399582 6 1,10-phenanthroline 874,893 AAP 797,800 1,10-phenanthroline AAP MESH:C025205 290 Chemical Gene leuhistin|conj|START_ENTITY bestatin|appos|leuhistin inhibited|nmod|bestatin inhibited|nsubj|END_ENTITY AAP was potently inhibited by bestatin , leuhistin , actinonin , amastatin , and 1,10-phenanthroline . 17680773 9 1,10-phenanthroline 1673,1692 Abeta 1627,1632 1,10-phenanthroline Abeta MESH:C025205 351 Chemical Gene CQ|conj|START_ENTITY -LSB-|dobj|CQ -LSB-|nsubj|levels levels|compound|END_ENTITY Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta . 17680773 9 1,10-phenanthroline 1673,1692 Abeta 1855,1860 1,10-phenanthroline Abeta MESH:C025205 351 Chemical Gene CQ|conj|START_ENTITY -LSB-|dobj|CQ inhibited|ccomp|-LSB- ligands|acl:relcl|inhibited induced|nsubj|ligands induced|advcl|resulting resulting|nmod|up-regulation up-regulation|conj|loss loss|nmod|END_ENTITY Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta . 18463291 4 1,10-phenanthroline 432,451 Abeta 510,515 1,10-phenanthroline Abeta MESH:C025205 11820(Tax:10090) Chemical Gene derivatives|amod|START_ENTITY L|ccomp|derivatives range|dep|L bind|nsubj|range bind|nmod|END_ENTITY To test this hypothesis , a range of L-PtCl -LRB- 2 -RRB- -LRB- L = 1,10-phenanthroline derivatives -RRB- complexes were examined and shown to bind to Abeta , inhibit neurotoxicity and rescue Abeta-induced synaptotoxicity in mouse hippocampal slices . 18463291 7 1,10-phenanthroline 931,950 Abeta 989,994 1,10-phenanthroline Abeta MESH:C025205 11820(Tax:10090) Chemical Gene planar|amod|START_ENTITY ligands|nsubj|planar ligands|ccomp|confer confer|dobj|specificity specificity|nmod|END_ENTITY This implies that the planar aromatic 1,10-phenanthroline ligands L confer some specificity for Abeta onto the platinum complexes . 2965871 2 1,10-phenanthroline 320,339 ACE 486,489 1,10-phenanthroline ACE MESH:C025205 24310(Tax:10116) Chemical Gene ANP|conj|START_ENTITY ANP|conj|phenylmethylsulphonyl_fluoride phenylmethylsulphonyl_fluoride|conj|SQ_20881 SQ_20881|compound|END_ENTITY Degradation of -LSB- 125I -RSB- - ANP is antagonized by unlabelled ANP , bradykinin , glucagon , 1,10-phenanthroline , PCMB , EDTA and the bacterial antibiotic bacitracin , but not by phenylmethylsulphonyl_fluoride , aprotinin , phosphoramidon , E-64 , amastatin or the ACE inhibitor SQ_20881 and bradykinin_potentiator_C . 6259546 2 1,10-phenanthroline 386,405 acetylcholinesterase 348,368 1,10-phenanthroline acetylcholinesterase MESH:C025205 11423(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|release release|nmod|END_ENTITY The collagenase-stimulated release of acetylcholinesterase was inhibited by 1,10-phenanthroline , an inhibitor of collagenase . 23408593 5 1,10-phenanthroline 656,675 AChE 693,697 1,10-phenanthroline AChE MESH:C025205 43 Chemical Gene effect|nmod|START_ENTITY high|nsubj|effect high|nmod|activity activity|compound|END_ENTITY The inhibitory effect of 1,10-phenanthroline was high towards AChE esterase activity . 23408593 7 1,10-phenanthroline 922,941 AChE 907,911 1,10-phenanthroline AChE MESH:C025205 43 Chemical Gene inhibits|amod|START_ENTITY esterase|nsubj|inhibits show|ccomp|esterase show|nsubj|studies studies|nmod|forms forms|nmod|END_ENTITY Kinetic studies on both forms of AChE show that 1,10-phenanthroline inhibits esterase in competitive and AAA activity in non-competitive manner . 23408593 8 1,10-phenanthroline 1074,1093 AChE 1108,1112 1,10-phenanthroline AChE MESH:C025205 43 Chemical Gene inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY Protection studies further revealed that the nature of 1,10-phenanthroline inhibition on AChE is through its direct binding to protein rather than its metal chelation property . 3161078 4 1,10-phenanthroline 785,804 ADH 1018,1021 1,10-phenanthroline ADH MESH:C025205 10327 Chemical Gene 4-Methylpyrazole|conj|START_ENTITY inhibit|dep|4-Methylpyrazole inhibit|nsubj|oxidation oxidation|acl|indicating indicating|ccomp|interact interact|nmod|site site|nmod|END_ENTITY 4-Methylpyrazole and 1,10-phenanthroline inhibit the class I ADH-catalyzed oxidation of HMPG , DHPG , and ethanol with inhibition constants of 75-90 nM and 19-22 microM , respectively , indicating that these substrates interact at the same catalytic site of ADH . 2157617 6 1,10-phenanthroline 970,989 AhR 1123,1126 1,10-phenanthroline AhR MESH:C025205 196 Chemical Gene inhibited|nsubj|START_ENTITY observed|advcl|inhibited observed|nsubj|inhibition inhibition|nmod|END_ENTITY Here , we report that although 1,10-phenanthroline , a metal ion chelating agent , inhibited the DNA binding of SP1_and_transformed_glucocorticoid_receptor , no inhibition of transformed AhR was observed . 2160969 7 1,10-phenanthroline 989,1008 AH_receptor 1085,1096 1,10-phenanthroline AH receptor MESH:C025205 25690(Tax:10116) Chemical Gene chelators|amod|START_ENTITY inhibited|nsubj|chelators inhibited|dobj|activity activity|nmod|END_ENTITY The chelators 1,10-phenanthroline and oxalic_acid inhibited the sequence-specific DNA-binding activity of the AH_receptor in a concentration dependent manner , suggesting that the DNA-binding activity of the receptor requires divalent metal ions . 19896525 1 1,10-phenanthroline 96,115 AKR1C1 202,208 1,10-phenanthroline AKR1C1 MESH:C025205 1645 Chemical Gene phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|nmod|aldo-keto_reductases_1C1 aldo-keto_reductases_1C1|appos|END_ENTITY 1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level . 6716101 5 1,10-phenanthroline 390,409 ALAD 367,371 1,10-phenanthroline ALAD MESH:C025205 510679(Tax:9913) Chemical Gene inactivated|nmod|START_ENTITY inactivated|nsubjpass|END_ENTITY ALAD is inactivated by 1,10-phenanthroline or ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- but not by monodentate anions like cyanide or sulfide . 21515032 0 1,10-phenanthroline 98,117 albumin 12,19 1,10-phenanthroline albumin MESH:C025205 213 Chemical Gene ligand|amod|START_ENTITY containing|dobj|ligand complex|acl|containing studies|nmod|complex END_ENTITY|dobj|studies Human serum albumin binding and cytotoxicity studies of surfactant-cobalt -LRB- III -RRB- complex containing 1,10-phenanthroline ligand . 6986372 1 1,10-phenanthroline 168,187 alcohol_dehydrogenase 122,143 1,10-phenanthroline alcohol dehydrogenase MESH:C025205 10327 Chemical Gene chelation|acl|START_ENTITY studied|nsubjpass|chelation studied|advcl|elucidate elucidate|nmod|catalysis catalysis|compound|END_ENTITY To elucidate the role of zinc-bound water in liver alcohol_dehydrogenase catalysis , chelation by 1,10-phenanthroline and 2,2-bipyridine was studied . 19896525 1 1,10-phenanthroline 96,115 aldo-keto_reductases_1C1 176,200 1,10-phenanthroline aldo-keto reductases 1C1 MESH:C025205 1645 Chemical Gene phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|nmod|END_ENTITY 1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level . 2173552 20 1,10-phenanthroline 1674,1693 alpha_1-AT 1637,1647 1,10-phenanthroline alpha 1-AT MESH:C025205 5265 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|cleavage cleavage|amod|END_ENTITY alpha_1-AT cleavage was inhibited by 1,10-phenanthroline and by high concentrations of collagen . 1711895 3 1,10-phenanthroline 543,562 alpha_2-macroglobulin 480,501 1,10-phenanthroline alpha 2-macroglobulin MESH:C025205 2 Chemical Gene inhibited|conj|START_ENTITY inhibited|nmod|END_ENTITY The purified enzyme was completely inhibited by alpha_2-macroglobulin and the chelating agents EDTA , EGTA , and 1,10-phenanthroline and was slightly inhibited by chymostatin and pepstatin , but was not inhibited by various other serine and thiol protease inhibitors . 2804981 2 1,10-phenanthroline 520,539 alpha-MSH 486,495 1,10-phenanthroline alpha-MSH MESH:C025205 5443 Chemical Gene mM|amod|START_ENTITY presence|nmod|mM END_ENTITY|nmod|presence Specific binding of high-performance liquid chromatography-purified , monoiodinated alpha-MSH in the presence of 1 mM 1,10-phenanthroline as protease inhibitor was highest after a 2-h incubation at 37 degrees C . 8024692 6 1,10-phenanthroline 1161,1180 alpha-tubulin 1220,1233 1,10-phenanthroline alpha-tubulin MESH:C025205 10376 Chemical Gene tested|nsubj|START_ENTITY tested|dobj|levels levels|amod|END_ENTITY In the presence of insulin , Northern analysis revealed that 1,10-phenanthroline at all concentrations tested increased alpha-tubulin mRNA levels , but had a biphasic effect on insulin-stimulated immediate-early gene expression . 8024692 9 1,10-phenanthroline 1680,1699 alpha-tubulin 1802,1815 1,10-phenanthroline alpha-tubulin MESH:C025205 10376 Chemical Gene concentrations|nmod|START_ENTITY decreased|nsubj|concentrations decreased|conj|had had|dobj|effect effect|nmod|transcription transcription|nmod|END_ENTITY Nuclear run-on analysis demonstrated that high concentrations of 1,10-phenanthroline decreased insulin-stimulated immediate-early gene transcription but had no effect on transcription of alpha-tubulin . 10649451 5 1,10-phenanthroline 600,619 aminopeptidase 676,690 1,10-phenanthroline aminopeptidase MESH:C025205 856811(Tax:4932) Chemical Gene PMSF|amod|START_ENTITY inhibitors|nsubj|PMSF inhibitors|nmod|activity activity|amod|END_ENTITY PMSF , Cu -LRB- 2 + -RRB- , 1,10-phenanthroline and bestatin were found to be very strong inhibitors of aminopeptidase yscCo-II activity . 1417757 4 1,10-phenanthroline 521,540 aminopeptidase 568,582 1,10-phenanthroline aminopeptidase MESH:C025205 100533385 Chemical Gene agent|amod|START_ENTITY inhibited|nsubj|agent inhibited|dobj|activity activity|compound|END_ENTITY The bivalent-cation-chelating agent , 1,10-phenanthroline , inhibited kidney membrane aminopeptidase activity with an IC50 of 30 microM , suggesting that this enzyme is a metalloproteinase . 16666602 6 1,10-phenanthroline 876,895 aminopeptidase 750,764 1,10-phenanthroline aminopeptidase MESH:C025205 10404 Chemical Gene SH-reagents|conj|START_ENTITY inhibited|nmod|SH-reagents inhibited|nsubjpass|activity activity|nmod|II II|amod|END_ENTITY The activity of aminopeptidase II was inhibited by the SH-reagents p-chloromercuribenzoic_acid and N-ethylmaleimide and by the metal chelator 1,10-phenanthroline . 21167291 7 1,10-phenanthroline 1242,1261 aminopeptidase 1182,1196 1,10-phenanthroline aminopeptidase MESH:C025205 10404 Chemical Gene inhibited|conj|START_ENTITY inhibited|nsubj|activity activity|amod|END_ENTITY The aminopeptidase activity upon LpNA was inhibited by EDTA and 1,10-phenanthroline , indicating the importance of metal ions in enzyme catalysis . 2607648 3 1,10-phenanthroline 510,529 aminopeptidase 401,415 1,10-phenanthroline aminopeptidase MESH:C025205 10404 Chemical Gene derivatives|amod|START_ENTITY selected|nmod|derivatives selected|nsubjpass|such such|nmod|END_ENTITY At first , more specific and adequate inhibitor for other serum peptidases , such as membrane-bound aminopeptidase -LRB- EC 3.4.11.2 ; arylamidase , AA -RRB- and cystyl aminopeptidase -LRB- EC 3.4.11.3 ; CAP -RRB- was selected from 1,10-phenanthroline derivatives . 2607648 3 1,10-phenanthroline 510,529 aminopeptidase 458,472 1,10-phenanthroline aminopeptidase MESH:C025205 10404 Chemical Gene derivatives|amod|START_ENTITY selected|nmod|derivatives selected|nsubjpass|such such|nmod|aminopeptidase END_ENTITY|conj|aminopeptidase At first , more specific and adequate inhibitor for other serum peptidases , such as membrane-bound aminopeptidase -LRB- EC 3.4.11.2 ; arylamidase , AA -RRB- and cystyl aminopeptidase -LRB- EC 3.4.11.3 ; CAP -RRB- was selected from 1,10-phenanthroline derivatives . 1967220 5 1,10-phenanthroline 1234,1253 Aminopeptidase 1053,1067 1,10-phenanthroline Aminopeptidase MESH:C025205 10404 Chemical Gene blocked|nmod|START_ENTITY demonstrated|conj|blocked demonstrated|nsubjpass|activity activity|amod|END_ENTITY Aminopeptidase activity was demonstrated for CD13 molecules specifically immunoprecipitated from the surface of CD13-positive cells and was blocked by the metalloprotease inhibitor 1,10-phenanthroline . 8141778 3 1,10-phenanthroline 678,697 aminopeptidase_A 777,793 1,10-phenanthroline aminopeptidase A MESH:C025205 2028 Chemical Gene amastatin|conj|START_ENTITY inhibition|nmod|amastatin characteristic|nsubj|inhibition characteristic|nmod|END_ENTITY The inhibition by amastatin and 1,10-phenanthroline , and the activation by CaCl2 are characteristic of the cell-surface ectoenzyme aminopeptidase_A -LRB- EC 3.4.11.7 -RRB- and a purified preparation of this enzyme hydrolysed aspartame with a Km of 0.25 mM and a Vmax of 126 mumol/min per mg . 2875994 3 1,10-phenanthroline 552,571 aminopeptidase_M 633,649 1,10-phenanthroline aminopeptidase M MESH:C025205 81641(Tax:10116) Chemical Gene inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY S - -LRB- 1,2-Dichlorovinyl -RRB- - L-cysteinylglycine , a putative metabolite of DCVG , also produced cell death , which was prevented by 1,10-phenanthroline , phenylalanylglycine , and aminooxyacetic_acid , inhibitors of aminopeptidase_M , cysteinylglycine dipeptidase , and cysteine conjugate beta-lyase , respectively . 9602161 3 1,10-phenanthroline 654,673 aminopeptidase_N 574,590 1,10-phenanthroline aminopeptidase N MESH:C025205 100127099(Tax:7091) Chemical Gene inhibited|nsubj|START_ENTITY estimated|conj|inhibited estimated|nsubjpass|content content|nmod|END_ENTITY The zinc content in purified aminopeptidase_N was estimated as approximately 0.72 mol/mol of the protein and 1,10-phenanthroline completely inhibited the enzyme activity , suggesting zinc requirement for the activity . 14612196 4 1,10-phenanthroline 467,486 Ang_1-9 407,414 1,10-phenanthroline Ang 1-9 MESH:C025205 305843(Tax:10116) Chemical Gene inhibitor|conj|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubjpass|formation formation|nmod|END_ENTITY The formation of Ang_1-9 was inhibited by potato carboxypeptidase inhibitor , 1,10-phenanthroline or EDTA . 18838088 4 1,10-phenanthroline 1072,1091 Ang_II 1024,1030 1,10-phenanthroline Ang II MESH:C025205 24179(Tax:10116) Chemical Gene inhibited|advcl|START_ENTITY inhibited|nsubjpass|cleavage cleavage|acl|Ang Ang|xcomp|Ang Ang|dobj|conversion conversion|conj|END_ENTITY The respective reactions , namely , Z-Val-Phe cleavage , Ang I to Ang 1-9 conversion and Ang_II to Ang 1-7 conversion , were inhibited by 1,10-phenanthroline and nearly fully blocked by potato carboxypeptidase inhibitor . 2317196 14 1,10-phenanthroline 2112,2131 angiotensin-converting_enzyme 2150,2179 1,10-phenanthroline angiotensin-converting enzyme MESH:C025205 613133(Tax:9823) Chemical Gene di-isopropylfluorophosphate|conj|START_ENTITY di-isopropylfluorophosphate|conj|END_ENTITY Various inhibitors were tested ; a few reagents , such as organic mercurials , di-isopropylfluorophosphate , 1,10-phenanthroline , sodium_azide and angiotensin-converting_enzyme inhibitor exhibited some inhibition -LRB- not more than 60 % -RRB- . 2983769 5 1,10-phenanthroline 775,794 angiotensin-converting_enzyme 686,715 1,10-phenanthroline angiotensin-converting enzyme MESH:C025205 24310(Tax:10116) Chemical Gene EDTA|conj|START_ENTITY chelators|amod|EDTA inhibition|nmod|chelators inhibition|nsubj|END_ENTITY Purified pulmonary angiotensin-converting_enzyme was more sensitive to inhibition by the chelators EDTA and 1,10-phenanthroline and by the site-directed inhibitor captopril than was the testicular isozyme . 3007669 1 1,10-phenanthroline 148,167 Angiotensin_converting_enzyme 89,118 1,10-phenanthroline Angiotensin converting enzyme MESH:C025205 1636 Chemical Gene form|nsubj|START_ENTITY chelator|acl|form interacts|nmod|chelator interacts|nsubj|END_ENTITY Angiotensin_converting_enzyme interacts with the chelator , 1,10-phenanthroline -LRB- OP -RRB- to form an OP-Zn-ACE ternary complex , which subsequently dissociates to OP-Zn and apoenzyme . 17145192 4 1,10-phenanthroline 717,736 angiotensin_I 829,842 1,10-phenanthroline angiotensin I MESH:C025205 183 Chemical Gene EDTA|conj|START_ENTITY inhibited|advcl|EDTA inhibited|conj|released released|nmod|END_ENTITY gACE was potently inhibited by EDTA , 1,10-phenanthroline , captopril and lisinopril , and it promptly released the dipeptides_His-Leu and Phe-Arg from angiotensin_I and bradykinin . 16297670 6 1,10-phenanthroline 1128,1147 AphA 1058,1062 1,10-phenanthroline AphA MESH:C025205 948562(Tax:511145) Chemical Gene agents|amod|START_ENTITY inhibited|nmod|agents inhibited|nsubjpass|END_ENTITY AphA was inhibited by several chelating agents , including EDTA , EGTA , 1,10-phenanthroline and dipicolinic_acid , with EDTA being apparently the most powerful inhibitor . 17109655 2 1,10-phenanthroline 483,502 AP-N 565,569 1,10-phenanthroline AP-N MESH:C025205 290 Chemical Gene produced|nsubj|START_ENTITY produced|dobj|inhibition inhibition|nmod|END_ENTITY Whereas pre-incubation for 10 min with ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- , did not or only weakly affected the enzyme activity , the bidentate chelator 1,10-phenanthroline produced a complete and concentration-dependent inhibition of AP-N . 1720775 5 1,10-phenanthroline 697,716 Apn1 630,634 1,10-phenanthroline Apn1 MESH:C025205 853746(Tax:4932) Chemical Gene treated|nmod|START_ENTITY IV|acl|treated ineffective|nmod|IV reactivated|conj|ineffective reactivated|dobj|END_ENTITY ZnCl2 reactivated 1,10-phenanthroline-treated Apn1 , but was ineffective with endonuclease IV treated with either 1,10-phenanthroline or EDTA . 10875440 3 1,10-phenanthroline 661,680 APP 726,729 1,10-phenanthroline APP MESH:C025205 100689222 Chemical Gene presence|nmod|START_ENTITY concentrations|conj|presence up|nmod|concentrations zinc|advmod|up increased|nsubj|zinc increased|dobj|level level|nmod|END_ENTITY The data show that zinc up to concentrations of 50 microM or the presence of 1,10-phenanthroline specifically increased the level of secreted APP in CHO-K1 cells . 1510698 8 1,10-phenanthroline 822,841 APP 802,805 1,10-phenanthroline APP MESH:C025205 351 Chemical Gene inhibited|advcl|START_ENTITY inhibited|nsubjpass|END_ENTITY Platelet APP is inhibited by 1,10-phenanthroline and activated by Mn2 + , thus confirming its metalloprotease nature . 11106490 7 1,10-phenanthroline 1017,1036 AP-P 1107,1111 1,10-phenanthroline AP-P MESH:C025205 351 Chemical Gene START_ENTITY|conj|inhibitor inhibitor|nmod|form form|nmod|END_ENTITY Hydrolysis of bradykinin was inhibited by 1,10-phenanthroline and by the specific inhibitor of the membrane-bound form of mammalian AP-P , apstatin . 8460139 3 1,10-phenanthroline 826,845 arcA 718,722 1,10-phenanthroline arcA MESH:C025205 9845996 Chemical Gene dehydrogenase|nmod|START_ENTITY induction|conj|dehydrogenase dependent|nsubj|induction caused|parataxis|dependent caused|ccomp|fnr fnr|nsubj|induction induction|nmod|MnSOD MnSOD|nmod|END_ENTITY Metal chelating agents also caused anaerobic induction of MnSOD in a fur arcA fnr triple mutant ; however , this induction of MnSOD and of glucose-6-phosphate dehydrogenase -LRB- G6PD -RRB- by 1,10-phenanthroline was dependent on an intact soxRS locus . 12450410 6 1,10-phenanthroline 541,560 AtzA 518,522 1,10-phenanthroline AtzA MESH:C025205 1440573(Tax:47660) Chemical Gene chelator|amod|START_ENTITY incubating|nmod|chelator incubating|dobj|END_ENTITY Loss of activity obtained by incubating AtzA with the chelator 1,10-phenanthroline or oxalic_acid was reversible upon addition of Fe -LRB- II -RRB- , Mn -LRB- II -RRB- , or Co -LRB- II -RRB- salts . 9030778 5 1,10-phenanthroline 1017,1036 axonin-1 1118,1126 1,10-phenanthroline axonin-1 MESH:C025205 419825(Tax:9031) Chemical Gene reduces|nsubj|START_ENTITY reduces|dobj|release release|nmod|END_ENTITY Secreted axonin-1 does not exhibit the cross-reacting determinant epitope , an indication that the cleavage of the anchor is not mediated by a phosphatidylinositol-specific phospholipase C. Treatment of dorsal root ganglion neurons with 1,10-phenanthroline , an inhibitor of glycosylPtdIns-specific phospholipase D , reduces the release of axonin-1 by 56 % . 9030778 5 1,10-phenanthroline 1017,1036 axonin-1 790,798 1,10-phenanthroline axonin-1 MESH:C025205 419825(Tax:9031) Chemical Gene reduces|nsubj|START_ENTITY exhibit|dep|reduces exhibit|dep|END_ENTITY Secreted axonin-1 does not exhibit the cross-reacting determinant epitope , an indication that the cleavage of the anchor is not mediated by a phosphatidylinositol-specific phospholipase C. Treatment of dorsal root ganglion neurons with 1,10-phenanthroline , an inhibitor of glycosylPtdIns-specific phospholipase D , reduces the release of axonin-1 by 56 % . 11928813 7 1,10-phenanthroline 1293,1312 BB3103 1282,1288 1,10-phenanthroline BB3103 MESH:C025205 2663635(Tax:257310) Chemical Gene inhibitors|conj|START_ENTITY inhibitors|conj|END_ENTITY The finding that both neuroblastoma clones exposed to the metalloproteinase inhibitors , BB3103 and 1,10-phenanthroline , increased their differentiative capacity and reduced their invasiveness through Matrigel , represents a further indication that PAF modulates differentiation and invasiveness by affecting the activity of MMPs . 19505802 3 1,10-phenanthroline 424,443 BB-3497 404,411 1,10-phenanthroline BB-3497 MESH:C025205 2659607(Tax:257310) Chemical Gene END_ENTITY|conj|START_ENTITY In the present study , various well-known PDF inhibitors , such as BB-3497 , actinonin , 1,10-phenanthroline , hydroxylamine_hydrochloride and galardin , were selected to evaluate their inhibitory activity against Mycobacterium_tuberculosis . 19505802 5 1,10-phenanthroline 801,820 BB-3497 789,796 1,10-phenanthroline BB-3497 MESH:C025205 2659607(Tax:257310) Chemical Gene END_ENTITY|conj|START_ENTITY BB-3497 and 1,10-phenanthroline exhibited potent in vitro antimycobacterial activity , and also showed synergism with isoniazid and rifampicin . 15990199 7 1,10-phenanthroline 1198,1217 BDNF 1156,1160 1,10-phenanthroline BDNF MESH:C025205 24225(Tax:10116) Chemical Gene abolished|nsubj|START_ENTITY microglia|acl:relcl|abolished expression|nmod|microglia contrast|dep|expression contrast|appos|END_ENTITY These profiles contrast to the data with morphine-induced enhancement of brain-derived growth factor -LRB- BDNF -RRB- gene expression in microglia , where 1,10-phenanthroline abolished the expression . 10604529 1 1,10-phenanthroline 487,506 BK2 589,592 1,10-phenanthroline BK2 MESH:C025205 624 Chemical Gene nitroarginine|conj|START_ENTITY prevented|nmod|nitroarginine prevented|conj|involve involve|dobj|receptors receptors|compound|BK1 BK1|conj|END_ENTITY Such a potentiation was prevented and reversed only by nitroarginine or 1,10-phenanthroline -LRB- PHE -RRB- -LRB- which also reduced basal jugular NO levels -RRB- and did not involve the BK1 or BK2 receptors . 11106490 7 1,10-phenanthroline 1017,1036 bradykinin 989,999 1,10-phenanthroline bradykinin MESH:C025205 3827 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|Hydrolysis Hydrolysis|nmod|END_ENTITY Hydrolysis of bradykinin was inhibited by 1,10-phenanthroline and by the specific inhibitor of the membrane-bound form of mammalian AP-P , apstatin . 17145192 4 1,10-phenanthroline 717,736 bradykinin 847,857 1,10-phenanthroline bradykinin MESH:C025205 3827 Chemical Gene EDTA|conj|START_ENTITY inhibited|advcl|EDTA inhibited|conj|released released|nmod|angiotensin_I angiotensin_I|conj|END_ENTITY gACE was potently inhibited by EDTA , 1,10-phenanthroline , captopril and lisinopril , and it promptly released the dipeptides_His-Leu and Phe-Arg from angiotensin_I and bradykinin . 3039382 6 1,10-phenanthroline 747,766 bradykinin 794,804 1,10-phenanthroline bradykinin MESH:C025205 3827 Chemical Gene did|nsubj|START_ENTITY did|dobj|breakdown breakdown|nmod|END_ENTITY 1,10-phenanthroline did attenuate breakdown of bradykinin but this was found not to be significant compared with controls . 21491938 1 1,10-phenanthroline 168,187 C-3 91,94 1,10-phenanthroline C-3 MESH:C025205 718 Chemical Gene using|xcomp|START_ENTITY time|acl|using developed|nmod|time developed|nsubjpass|olefination olefination|compound|END_ENTITY Pd-catalyzed C-3 selective olefination of pyridines is developed for the first time using 1,10-phenanthroline as the ligand . 2158096 4 1,10-phenanthroline 487,506 CAP 391,394 1,10-phenanthroline CAP MESH:C025205 20468888 Chemical Gene chelator|amod|START_ENTITY incorporation|nmod|chelator converted|nmod|incorporation converted|nsubjpass|END_ENTITY In this work , CAP has been converted into a site-specific DNA cleavage agent by incorporation of the chelator 1,10-phenanthroline at amino_acid 10 of the helix-turn-helix motif . 9922230 9 1,10-phenanthroline 1357,1376 CAP1 1193,1197 1,10-phenanthroline CAP1 MESH:C025205 853862(Tax:4932) Chemical Gene cadmium|conj|START_ENTITY caused|nmod|cadmium affect|conj|caused affect|nsubj|deletion deletion|nmod|END_ENTITY We found that deletion of CAP1 did not affect the susceptibility of CJD21 cells to FCZ , cerulenin , brefeldin_A , and diamide but caused hypersensitivity to cadmium , 4-nitroquinoline_N-oxide , 1,10-phenanthroline , and hydrogen_peroxide , an effect which was reverted by reintroduction of the CAP1 gene in these cells . 9922230 9 1,10-phenanthroline 1357,1376 CAP1 1455,1459 1,10-phenanthroline CAP1 MESH:C025205 853862(Tax:4932) Chemical Gene cadmium|conj|START_ENTITY cadmium|appos|effect effect|acl:relcl|reverted reverted|nmod|reintroduction reintroduction|nmod|gene gene|compound|END_ENTITY We found that deletion of CAP1 did not affect the susceptibility of CJD21 cells to FCZ , cerulenin , brefeldin_A , and diamide but caused hypersensitivity to cadmium , 4-nitroquinoline_N-oxide , 1,10-phenanthroline , and hydrogen_peroxide , an effect which was reverted by reintroduction of the CAP1 gene in these cells . 1793037 5 1,10-phenanthroline 833,852 carboxypeptidase_B 890,908 1,10-phenanthroline carboxypeptidase B MESH:C025205 24271(Tax:10116) Chemical Gene captopril|conj|START_ENTITY coinjection|nmod|captopril increased|nmod|coinjection increased|conj|prevented prevented|nmod|END_ENTITY The hyperalgesic effect of BK -LRB- 1 micrograms -RRB- injected into the hindpaw of rats was significantly increased and prolonged by coinjection of captopril -LRB- 30 micrograms -RRB- and 1,10-phenanthroline -LRB- 30 micrograms -RRB- and was prevented by carboxypeptidase_B -LRB- 1 mg -RRB- . 6326144 8 1,10-phenanthroline 1712,1731 carboxypeptidase_B 1635,1653 1,10-phenanthroline carboxypeptidase B MESH:C025205 24271(Tax:10116) Chemical Gene EDTA|conj|START_ENTITY chelators|amod|EDTA inhibitors|conj|chelators inhibitors|conj|inhibitor inhibitor|compound|END_ENTITY Inhibition by the zinc metallocarboxypeptidase inhibitors guanidinopropylsuccinic_acid , aminomercaptosuccinic_acid , benzylsuccinic_acid , 2-mercaptomethyl-3-guanidinoethylthiopropanoic_acid , and the potato carboxypeptidase_B inhibitor , and inhibition by the metal chelators EDTA and 1,10-phenanthroline demonstrate metal ion dependence of the pituitary granule carboxypeptidase activities . 10190127 7 1,10-phenanthroline 1185,1204 caspase_3 1211,1220 1,10-phenanthroline caspase 3 MESH:C025205 836 Chemical Gene ammonium_pyrrolidinedithiocarbamate|conj|START_ENTITY ammonium_pyrrolidinedithiocarbamate|conj|inhibitor inhibitor|amod|END_ENTITY Hydrogen_peroxide-induced cell injury and DNA fragmentation were attenuated by the NF-kappa B inhibitor ammonium_pyrrolidinedithiocarbamate , 1,10-phenanthroline and a caspase_3 inhibitor . 17251461 5 1,10-phenanthroline 619,638 cathepsin_B 658,669 1,10-phenanthroline cathepsin B MESH:C025205 1508 Chemical Gene GM-6001|dep|START_ENTITY MMPs|appos|GM-6001 MMPs|conj|cathepsins cathepsins|appos|E64 E64|dep|II II|compound|END_ENTITY In HLE/DAM cultures , inhibitors of MMPs -LRB- GM-6001 ; 1,10-phenanthroline -RRB- , cathepsins -LRB- E64 ; cathepsin_B inhibitor II -RRB- , elastase -LRB- elastatinal -RRB- , and serine proteases -LRB- AEBSF ; aprotinin -RRB- were added . 22957890 1 1,10-phenanthroline 249,268 CCR1 142,146 1,10-phenanthroline CCR1 MESH:C025205 1230 Chemical Gene bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nmod|receptors receptors|appos|END_ENTITY Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- . 24083637 2 1,10-phenanthroline 423,442 CCR1 308,312 1,10-phenanthroline CCR1 MESH:C025205 1230 Chemical Gene terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|END_ENTITY We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine . 22957890 1 1,10-phenanthroline 249,268 CCR4 148,152 1,10-phenanthroline CCR4 MESH:C025205 1233 Chemical Gene bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|END_ENTITY Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- . 22957890 1 1,10-phenanthroline 249,268 CCR5 154,158 1,10-phenanthroline CCR5 MESH:C025205 1234 Chemical Gene bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|CCR4 CCR4|conj|END_ENTITY Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- . 24083637 2 1,10-phenanthroline 423,442 CCR5 324,328 1,10-phenanthroline CCR5 MESH:C025205 1234 Chemical Gene terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|CCR1 CCR1|conj|END_ENTITY We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine . 22957890 1 1,10-phenanthroline 249,268 CCR8 164,168 1,10-phenanthroline CCR8 MESH:C025205 1237 Chemical Gene bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|CCR4 CCR4|conj|END_ENTITY Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- . 24083637 2 1,10-phenanthroline 423,442 CCR8 314,318 1,10-phenanthroline CCR8 MESH:C025205 1237 Chemical Gene terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|CCR1 CCR1|conj|END_ENTITY We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine . 7529789 8 1,10-phenanthroline 1077,1096 CD106 1229,1234 1,10-phenanthroline CD106 MESH:C025205 7412 Chemical Gene EDTA|conj|START_ENTITY inhibit|nsubj|EDTA inhibit|dobj|conversion conversion|nmod|membrane membrane|acl|anchored anchored|nmod|form form|nmod|molecule molecule|compound|END_ENTITY EDTA and 1,10-phenanthroline , two potent inhibitors of metalloproteases , specifically inhibit the conversion of the membrane anchored to the soluble form of the CD106 molecule . 1967220 5 1,10-phenanthroline 1234,1253 CD13 1098,1102 1,10-phenanthroline CD13 MESH:C025205 290 Chemical Gene blocked|nmod|START_ENTITY demonstrated|conj|blocked demonstrated|nmod|molecules molecules|nummod|END_ENTITY Aminopeptidase activity was demonstrated for CD13 molecules specifically immunoprecipitated from the surface of CD13-positive cells and was blocked by the metalloprotease inhibitor 1,10-phenanthroline . 1834741 8 1,10-phenanthroline 1092,1111 CD16 1082,1086 1,10-phenanthroline CD16 MESH:C025205 2214 Chemical Gene inhibits|amod|START_ENTITY END_ENTITY|conj|inhibits Murine P815 mastocytoma cells transfected with human CD16-II cDNA shed membrane CD16 , and 1,10-phenanthroline inhibits this process . 7507963 4 1,10-phenanthroline 395,414 CD16 596,600 1,10-phenanthroline CD16 MESH:C025205 2214 Chemical Gene inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|CD43 CD43|conj|END_ENTITY Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes . 17467053 7 1,10-phenanthroline 1127,1146 CD34 1092,1096 1,10-phenanthroline CD34 MESH:C025205 947 Chemical Gene pretreatment|amod|START_ENTITY decreased|nmod|pretreatment decreased|advcl|induced induced|dobj|migration migration|conj|END_ENTITY While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment . 20417561 6 1,10-phenanthroline 711,730 CD4 590,593 1,10-phenanthroline CD4 MESH:C025205 920 Chemical Gene inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited Lck|nmod|interaction associate|nmod|Lck associate|nsubj|END_ENTITY CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline . 20417561 7 1,10-phenanthroline 826,845 CD4 755,758 1,10-phenanthroline CD4 MESH:C025205 920 Chemical Gene presence|nmod|START_ENTITY abolished|nmod|presence abolished|nsubjpass|END_ENTITY Here we show that both CD4 and CD44-mediated T cell spreading is abolished in the presence of 1,10-phenanthroline and their association with Lck is significantly reduced . 7507963 4 1,10-phenanthroline 395,414 CD43 580,584 1,10-phenanthroline CD43 MESH:C025205 6693 Chemical Gene inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|END_ENTITY Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes . 7683406 6 1,10-phenanthroline 1138,1157 CD43 1058,1062 1,10-phenanthroline CD43 MESH:C025205 6693 Chemical Gene blocked|nmod|START_ENTITY blocked|nsubj|down-regulation down-regulation|nmod|END_ENTITY Importantly , PMA-induced down-regulation of CD43 on granulocytes was markedly blocked both by the metalloprotease inhibitor 1,10-phenanthroline and by the serine protease inhibitors N_alpha - -LRB- p-tosyl -RRB- - L-lysine_chloromethyl_ketone and Pefabloc SC , which inhibit two different classes of proteases , thus indicating that the release is proteolytic . 10050880 8 1,10-phenanthroline 1113,1132 CD44 1161,1165 1,10-phenanthroline CD44 MESH:C025205 960 Chemical Gene treatment|nmod|START_ENTITY treatment|acl:relcl|prevent prevent|dobj|cleavage cleavage|compound|END_ENTITY Interestingly , treatment with the metalloprotease blocker 1,10-phenanthroline , which strongly prevent the CD44 cleavage , suppressed RERF-LC-OK lung_cancer cell migration on a hyaluronate substrate , but not on several other substrates . 17912438 10 1,10-phenanthroline 1745,1764 CD44 1533,1537 1,10-phenanthroline CD44 MESH:C025205 960 Chemical Gene inhibited|conj|START_ENTITY membranes|acl:relcl|inhibited migrate|nmod|membranes invade|conj|migrate enhances|xcomp|invade enhances|nsubj|crosslinking crosslinking|nmod|END_ENTITY Furthermore , crosslinking of CD44 enhances the ability of breast_tumor cells to invade G8 myoblast monolayers and migrate through the basal membranes which was inhibited in the presence of anti-MMP-9 antibody or the MMP inhibitors GM6001 or 1,10-phenanthroline . 7507963 4 1,10-phenanthroline 395,414 CD44 586,590 1,10-phenanthroline CD44 MESH:C025205 960 Chemical Gene inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|CD43 CD43|conj|END_ENTITY Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes . 11027218 2 1,10-phenanthroline 600,619 CD45 425,429 1,10-phenanthroline CD45 MESH:C025205 19264(Tax:10090) Chemical Gene oxovanadate|dep|START_ENTITY co-treated|nmod|oxovanadate co-treated|advcl|investigate investigate|dobj|role role|nmod|END_ENTITY To investigate the possible role of CD45 in microglial responsiveness to beta-amyloid -LRB- Abeta -RRB- peptides , we first co-treated primary cultured microglia with a tyrosine phosphatase inhibitor -LSB- potassium bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate -LRB- phen -RRB- , 5 micrometer -RSB- and freshly solubilized Abeta peptides -LRB- 1000 nm -RRB- . 20417561 6 1,10-phenanthroline 711,730 CD8 598,601 1,10-phenanthroline CD8 MESH:C025205 925 Chemical Gene inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited Lck|nmod|interaction associate|nmod|Lck associate|nsubj|CD4 CD4|conj|END_ENTITY CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline . 9331970 4 1,10-phenanthroline 524,543 CDO 455,458 1,10-phenanthroline CDO MESH:C025205 114106(Tax:10116) Chemical Gene inactivated|advcl|START_ENTITY detected|conj|inactivated detected|nsubjpass|Activities Activities|conj|dioxygenase dioxygenase|appos|END_ENTITY Activities of ADO and beta-carotene-15 ,15 ' - dioxygenase -LRB- CDO -RRB- were detected in the presence of thiols and were inactivated by 1,10-phenanthroline . 15893415 5 1,10-phenanthroline 732,751 CEA 641,644 1,10-phenanthroline CEA MESH:C025205 1084 Chemical Gene suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activated|nsubjpass|release release|compound|END_ENTITY Furthermore , CEA release could be activated and inhibited by incubation of LS180 cells with suramin and 1,10-phenanthroline , compounds known to activate and inhibit GPI-PLD activity , respectively . 3342923 0 1,10-phenanthroline 28,47 ceruloplasmin 78,91 1,10-phenanthroline ceruloplasmin MESH:C025205 1356 Chemical Gene neocuproine|nummod|START_ENTITY Interaction|nmod|neocuproine Interaction|dep|dipyridyl dipyridyl|nmod|END_ENTITY Interaction of neocuproine , 1,10-phenanthroline and 2,2 ' - dipyridyl with human ceruloplasmin . 8135553 6 1,10-phenanthroline 1383,1402 ceruloplasmin 1326,1339 1,10-phenanthroline ceruloplasmin MESH:C025205 1356 Chemical Gene inhibited|conj|START_ENTITY inhibited|nsubj|degradation degradation|nmod|END_ENTITY The degradation of ceruloplasmin by this fraction was inhibited by EDTA and 1,10-phenanthroline , indicating that a plasma metalloproteinase is responsible for degradation of ceruloplasmin . 8024692 7 1,10-phenanthroline 1366,1385 c-fos 1438,1443 1,10-phenanthroline c-fos MESH:C025205 2353 Chemical Gene increased|nsubj|START_ENTITY increased|dobj|expression expression|nmod|g33 g33|conj|END_ENTITY At low concentrations -LRB- 5-200 microM -RRB- , 1,10-phenanthroline increased the expression of insulin-stimulated g33 , c-fos , and Egr-1 mRNA . 1330986 1 1,10-phenanthroline 227,246 Cl2 121,124 1,10-phenanthroline Cl2 MESH:C025205 70762(Tax:10090) Chemical Gene excess|nmod|START_ENTITY presence|nmod|excess sodium_borohydride|nmod|presence synthesized|nmod|sodium_borohydride synthesized|nsubjpass|END_ENTITY -LSB- 99Tc -LRB- phen -RRB- 3 -RSB- Cl2 was synthesized by reduction of pertechnetate with sodium_borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry , magnetic susceptibility measurements , and i.r. / vis/u . 17095094 0 1,10-phenanthroline 100,119 Cl2 60,63 1,10-phenanthroline Cl2 MESH:C025205 100862695 Chemical Gene bipyridine|conj|START_ENTITY complexes|dep|bipyridine complexes|amod|END_ENTITY Variation of DNA photocleavage efficiency for -LSB- -LRB- TL -RRB- 2Ru -LRB- dpp -RRB- -RSB- Cl2 complexes where TL = 2,2 ' - bipyridine , 1,10-phenanthroline , or 4,7-diphenyl-1 ,10 - phenanthroline . 17585756 2 1,10-phenanthroline 326,345 Clip 390,394 1,10-phenanthroline Clip MESH:C025205 6249 Chemical Gene phen|ccomp|START_ENTITY geometries|dep|phen imposed|nmod|geometries changes|acl|imposed changes|dep|abbreviated abbreviated|nmod|END_ENTITY Structural changes imposed on the coordination geometries of Cu -LRB- phen -RRB- -LRB- 2 -RRB- -LRB- +,2 + -RRB- -LRB- phen = 1,10-phenanthroline -RRB- linked by a serinol bridge -LRB- abbreviated as Clip -RRB- were studied , as well as their energetic profiles . 24442316 3 1,10-phenanthroline 599,618 CMCS 580,584 1,10-phenanthroline CMCS MESH:C025205 100036439(Tax:10090) Chemical Gene treatment|conj|START_ENTITY groups|compound|treatment END_ENTITY|dobj|groups 39 male BABL/c mice were randomly divided into four groups : normal control , model control , CMCS treatment and 1,10-phenanthroline treatment groups . 12033328 7 1,10-phenanthroline 1106,1125 CO2 1168,1171 1,10-phenanthroline CO2 MESH:C025205 717 Chemical Gene using|xcomp|START_ENTITY analysis|acl|using quenched|nsubj|analysis quenched|nmod|presence presence|nmod|END_ENTITY In contrast , Cu -LRB- II -RRB- analysis using the CL reagent 1,10-phenanthroline is completely quenched in the presence of CO2 -LRB- aq -RRB- . 12033328 9 1,10-phenanthroline 1503,1522 CO4 1376,1379 1,10-phenanthroline CO4 MESH:C025205 720 Chemical Gene luminol|conj|START_ENTITY enhance|advcl|luminol appears|xcomp|enhance implications|acl|appears has|dobj|implications has|nsubj|formation formation|dep|END_ENTITY The formation of * CO4 - has very important analytical implications since this species appears to enhance or quench the CL signal from luminol and 1,10-phenanthroline , respectively . 9447964 9 1,10-phenanthroline 1444,1463 CPEB 1488,1492 1,10-phenanthroline CPEB MESH:C025205 734470(Tax:8355) Chemical Gene ions|nmod|START_ENTITY Chelation|nmod|ions inhibits|nsubj|Chelation inhibits|dobj|ability ability|nmod|END_ENTITY Chelation of metal ions by 1,10-phenanthroline inhibits the ability of CPEB to bind RNA ; however , RNA binding is restored if the reaction is supplemented with zinc . 27188502 2 1,10-phenanthroline 244,263 CsF 306,309 1,10-phenanthroline CsF MESH:C025205 1437 Chemical Gene 2|conj|START_ENTITY acac|dep|2 showed|nsubj|acac showed|nmod|presence presence|nmod|END_ENTITY Ni -LRB- acac -RRB- 2 and 1,10-phenanthroline showed the best result in the presence of CsF and CuF2 at 120 degC . 19319442 2 1,10-phenanthroline 201,220 CuX 177,180 1,10-phenanthroline CuX MESH:C025205 1523 Chemical Gene END_ENTITY|conj|START_ENTITY In the presence of a small amount of CuX -LRB- X = Cl , Br , I -RRB- and 1,10-phenanthroline -LRB- phen -RRB- , the cross-coupling reactions of iodoarenes with trifluoromethylsilanes proceeded smoothly to afford trifluoromethylated aromatics in good yields . 19896525 1 1,10-phenanthroline 96,115 Cyp1a1 289,295 1,10-phenanthroline Cyp1a1 MESH:C025205 1543 Chemical Gene phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|conj|decreased decreased|ccomp|-LSB- -LSB-|dobj|pyrene pyrene|dep|cytochrome_P450_1a1 cytochrome_P450_1a1|appos|END_ENTITY 1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level . 15242816 5 1,10-phenanthroline 773,792 CYP3A 851,856 1,10-phenanthroline CYP3A MESH:C025205 170509(Tax:10116) Chemical Gene phenanthroline|amod|START_ENTITY use|nmod|phenanthroline decreased|nsubj|use decreased|dobj|stability stability|compound|END_ENTITY The use of 1,10-phenanthroline -LRB- phenanthroline -RRB- , an inhibitor of PLD activity , decreased CYP3A stability in incubated microsomes . 20857437 7 1,10-phenanthroline 967,986 cytochrome_c 1073,1085 1,10-phenanthroline cytochrome c MESH:C025205 54205 Chemical Gene START_ENTITY|conj|digestion digestion|nmod|END_ENTITY Using CF IR MALDESI , several chemical and biochemical reactions were monitored on-line : the chelation of 1,10-phenanthroline with iron -LRB- II -RRB- , insulin denaturation with 1,4-dithiothreitol , and tryptic digestion of cytochrome_c . 6773520 2 1,10-phenanthroline 253,272 cytochrome_P-450 354,370 1,10-phenanthroline cytochrome P-450 MESH:C025205 100328948(Tax:9986) Chemical Gene leads|amod|START_ENTITY salts|nmod|leads reaction|nmod|salts beta-naphthoflavone-inducible|nsubj|reaction beta-naphthoflavone-inducible|dobj|species species|amod|END_ENTITY In liver microsomal membranes from adult rabbits treated with beta-naphthoflavone , reaction with Cu2 + salts plus 1,10-phenanthroline leads to the cross-linking of the two specifically beta-naphthoflavone-inducible cytochrome_P-450 species , form 4 and form 6 , to form homo - and hetero-dimer species . 19896525 0 1,10-phenanthroline 0,19 cytochrome_P450_1a1 75,94 1,10-phenanthroline cytochrome P450 1a1 MESH:C025205 1543 Chemical Gene stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|nmod|enzyme enzyme|appos|END_ENTITY 1,10-phenanthroline stabilizes mRNA of the carcinogen-metabolizing enzyme , cytochrome_P450_1a1 . 19896525 1 1,10-phenanthroline 96,115 cytochrome_P450_1a1 268,287 1,10-phenanthroline cytochrome P450 1a1 MESH:C025205 1543 Chemical Gene phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|conj|decreased decreased|ccomp|-LSB- -LSB-|dobj|pyrene pyrene|dep|END_ENTITY 1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level . 9173902 1 1,10-phenanthroline 489,508 DD1 258,261 1,10-phenanthroline DD1 MESH:C025205 1645 Chemical Gene shows|nmod|START_ENTITY differ|parataxis|shows differ|nsubj|isoenzymes isoenzymes|appos|END_ENTITY Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids . 9173902 1 1,10-phenanthroline 489,508 DD1 414,417 1,10-phenanthroline DD1 MESH:C025205 1645 Chemical Gene shows|nmod|START_ENTITY shows|nsubj|END_ENTITY Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids . 9173902 1 1,10-phenanthroline 489,508 DD2 266,269 1,10-phenanthroline DD2 MESH:C025205 1646 Chemical Gene shows|nmod|START_ENTITY differ|parataxis|shows differ|nsubj|isoenzymes isoenzymes|appos|DD1 DD1|conj|END_ENTITY Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids . 9173902 1 1,10-phenanthroline 489,508 DD2 518,521 1,10-phenanthroline DD2 MESH:C025205 1646 Chemical Gene shows|nmod|START_ENTITY shows|advcl|oxidizes oxidizes|nsubj|END_ENTITY Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids . 7061389 10 1,10-phenanthroline 1276,1295 dehydrogenase 1160,1173 1,10-phenanthroline dehydrogenase MESH:C025205 24791362 Chemical Gene alpha,alpha-dipyridyl|conj|START_ENTITY inhibited|xcomp|alpha,alpha-dipyridyl inhibited|nsubj|END_ENTITY The purified formate dehydrogenase was strongly inhibited by cyanide -LRB- Ki = 6 microM -RRB- , azide -LRB- Ki = 39 microM -RRB- , alpha,alpha-dipyridyl , and 1,10-phenanthroline . 4206911 3 1,10-phenanthroline 219,238 diamine_oxidase 136,151 1,10-phenanthroline diamine oxidase MESH:C025205 26 Chemical Gene bipyridyl|amod|START_ENTITY reagents|dep|bipyridyl using|dobj|reagents studied|advcl|using studied|nsubjpass|inhibition inhibition|nmod|END_ENTITY The inhibition of diamine_oxidase has been studied by using the following copper-chelating reagents : 1,10-phenanthroline ; 2,2 ' - bipyridyl ; 8-hydroxyquinoline -LRB- oxine -RRB- ; diethyldithiocarbamate and dithio-oxamide -LRB- rubeanic_acid -RRB- . 27924438 3 1,10-phenanthroline 806,825 dmb 864,867 1,10-phenanthroline dmb MESH:C025205 282491(Tax:9913) Chemical Gene START_ENTITY|nmod:poss|END_ENTITY The ancillary ligands 1,10-phenanthroline -LRB- phen -RRB- , 4,4 ' - Dimethyl-2 ,2 ' - dipyridyl -LRB- dmb -RRB- and 2,2 ' - dipyridine -LRB- bpy -RRB- having been discovered found to be involved in bond formation with the phosphate backbone of nucleotide base pairs in ruthenium -LRB- II -RRB- complex-DNA docked complex . 10661869 5 1,10-phenanthroline 874,893 DPP_III 834,841 1,10-phenanthroline DPP III MESH:C025205 114591(Tax:10116) Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubj|END_ENTITY DPP_III was potently inhibited by EDTA , 1,10-phenanthroline , DFP , PCMBS and NEM . 10978617 6 1,10-phenanthroline 835,854 DPP_III 795,802 1,10-phenanthroline DPP III MESH:C025205 114591(Tax:10116) Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubj|END_ENTITY DPP_III was potently inhibited by EDTA , 1,10-phenanthroline , DFP , PCMBS , NEM , beta-ME and iodoacetamide . 1633843 6 1,10-phenanthroline 1126,1145 DT 1043,1045 1,10-phenanthroline DT MESH:C025205 13190(Tax:10090) Chemical Gene analogs|nmod|START_ENTITY presence|nmod|analogs assayed|nmod|presence assayed|nsubjpass|activity activity|compound|END_ENTITY In addition , DT activity was assayed in the presence of two non-chelating structural analogs of 1,10-phenanthroline . 7547986 3 1,10-phenanthroline 501,520 DTNB 555,559 1,10-phenanthroline DTNB MESH:C025205 13528(Tax:10090) Chemical Gene inhibited|conj|START_ENTITY inhibited|conj|END_ENTITY The dibasic cleaving enzyme was completely inhibited in the presence of 20-50 mM amine buffers , 0.1 mM EDTA , 0.5 mM 1,10-phenanthroline , 0.5 mM N-ethylmaleimide , and 1mM DTNB . 1992461 8 1,10-phenanthroline 1631,1650 ECE 1533,1536 1,10-phenanthroline ECE MESH:C025205 94204(Tax:10116) Chemical Gene phosphoramidon|conj|START_ENTITY inhibitors|amod|phosphoramidon blocked|nmod|inhibitors identified|ccomp|blocked identified|nsubjpass|activity activity|compound|END_ENTITY In a rabbit lung membrane preparation , ECE activity was identified that was blocked by the metalloprotease inhibitors phosphoramidon and 1,10-phenanthroline in a concentration-dependent manner . 20608701 2 1,10-phenanthroline 582,601 EDA 572,575 1,10-phenanthroline EDA MESH:C025205 1896 Chemical Gene carbon|amod|START_ENTITY Cu|conj|carbon Cu|appos|carbon carbon|dep|AC-CH AC-CH|xcomp|2 2|dep|END_ENTITY Three nanoporous sorbents containing chelating diamine functionalities were evaluated for Cu -LRB- 2 + -RRB- adsorption from natural waters : ethylenediamine functionalized self-assembled monolayers on mesoporous supports -LRB- EDA-SAMMS -RRB- , ethylenediamine functionalized activated carbon -LRB- AC-CH -LRB- 2 -RRB- - EDA -RRB- , and 1,10-phenanthroline functionalized mesoporous carbon -LRB- Phen-FMC -RRB- . 9321921 6 1,10-phenanthroline 1707,1726 EGFR 1540,1544 1,10-phenanthroline EGFR MESH:C025205 13649(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY caused|conj|inhibited caused|nsubj|ligands ligands|amod|END_ENTITY EGFR ligands caused upregulation of urokinase , urokinase receptor , and matrix metalloprotease-1 , and tubulogenesis could be inhibited by the metalloprotease inhibitor 1,10-phenanthroline . 20139904 4 1,10-phenanthroline 1155,1174 EGF-R 1234,1239 1,10-phenanthroline EGF-R MESH:C025205 1956 Chemical Gene AG1478|conj|START_ENTITY inhibited|nsubj|AG1478 inhibited|dobj|phosphorylation phosphorylation|nmod|END_ENTITY In addition , AG1478 , 1,10-phenanthroline , and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549 , HepG2 , and MDA-MB-231 cell lines . 8024692 7 1,10-phenanthroline 1366,1385 Egr-1 1449,1454 1,10-phenanthroline Egr-1 MESH:C025205 1958 Chemical Gene increased|nsubj|START_ENTITY increased|dobj|expression expression|nmod|g33 g33|conj|mRNA mRNA|compound|END_ENTITY At low concentrations -LRB- 5-200 microM -RRB- , 1,10-phenanthroline increased the expression of insulin-stimulated g33 , c-fos , and Egr-1 mRNA . 10556832 8 1,10-phenanthroline 1181,1200 elafin 1206,1212 1,10-phenanthroline elafin MESH:C025205 5266 Chemical Gene combination|nmod|START_ENTITY obtained|nmod|combination obtained|nmod|END_ENTITY Maximal inhibition of sCR1 shedding was obtained by a combination of 1,10-phenanthroline with elafin -LRB- 86 + / - 6 % -RRB- . 8347898 11 1,10-phenanthroline 1657,1676 enkephalin 1720,1730 1,10-phenanthroline enkephalin MESH:C025205 29237(Tax:10116) Chemical Gene capable|nsubj|START_ENTITY capable|advcl|inhibiting inhibiting|dobj|degradation degradation|compound|END_ENTITY In addition , the chelator 1,10-phenanthroline was also capable of effectively inhibiting enkephalin degradation , suggesting that the enzyme responsible has the characteristics of a metalloprotease . 6808517 3 1,10-phenanthroline 542,561 Enkephalin_convertase 463,484 1,10-phenanthroline Enkephalin convertase MESH:C025205 1363 Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA stimulated|conj|inhibited stimulated|nsubj|END_ENTITY Enkephalin_convertase is markedly stimulated by CoCl2 and inhibited by EDTA or 1,10-phenanthroline , unlike the lysosomal carboxypeptidase . 2491751 4 1,10-phenanthroline 815,834 epidermal_growth_factor 744,767 1,10-phenanthroline epidermal growth factor MESH:C025205 1950 Chemical Gene agent|amod|START_ENTITY chelating|dobj|agent metal|acl|chelating mimicked|nmod|metal mimicked|nsubjpass|activity activity|nmod|END_ENTITY The RBC cytolytic stimulating activity of epidermal_growth_factor could be mimicked by the metal chelating agent 1,10-phenanthroline , suggesting a possible role for calcium ions in the action of epidermal_growth_factor and proteases . 2491751 4 1,10-phenanthroline 815,834 epidermal_growth_factor 897,920 1,10-phenanthroline epidermal growth factor MESH:C025205 1950 Chemical Gene agent|amod|START_ENTITY chelating|dobj|agent chelating|advcl|suggesting suggesting|nmod|ions ions|nmod|action action|nmod|END_ENTITY The RBC cytolytic stimulating activity of epidermal_growth_factor could be mimicked by the metal chelating agent 1,10-phenanthroline , suggesting a possible role for calcium ions in the action of epidermal_growth_factor and proteases . 11701758 7 1,10-phenanthroline 1002,1021 ERK 913,916 1,10-phenanthroline ERK MESH:C025205 26413(Tax:10090) Chemical Gene U74500A|conj|START_ENTITY antioxidants|dep|U74500A treatment|nmod|antioxidants attenuated|nmod|treatment attenuated|nsubjpass|activation activation|compound|END_ENTITY Surprisingly , ERK activation was not attenuated by concomitant treatment with antioxidants -LRB- U74500A or 1,10-phenanthroline -RRB- at concentrations that blocked ROS generation . 24885237 5 1,10-phenanthroline 1027,1046 ERK 1135,1138 1,10-phenanthroline ERK MESH:C025205 24338(Tax:10116) Chemical Gene dismutase|conj|START_ENTITY dismutase|conj|nicotine nicotine|compound|END_ENTITY After 3-4 days of IH , extracellular_signal-regulated_kinases_1 / 2 -LRB- ERK1/2 -RRB- protein phosphorylation decreased , which could be reversed by superoxide dismutase -LRB- SOD -RRB- , 1,10-phenanthroline -LRB- Phe -RRB- , the PP2A phosphorylation inhibitors , okadaic_acid -LRB- OKA -RRB- and cantharidin , and the ERK phosphorylation activator nicotine -LRB- p < 0.05 -RRB- . 20139904 4 1,10-phenanthroline 1155,1174 ERK1/2 1244,1250 1,10-phenanthroline ERK1/2 MESH:C025205 5595;5594 Chemical Gene AG1478|conj|START_ENTITY inhibited|nsubj|AG1478 inhibited|dobj|phosphorylation phosphorylation|nmod|EGF-R EGF-R|conj|END_ENTITY In addition , AG1478 , 1,10-phenanthroline , and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549 , HepG2 , and MDA-MB-231 cell lines . 24885237 5 1,10-phenanthroline 1027,1046 ERK1/2 929,935 1,10-phenanthroline ERK1/2 MESH:C025205 50689;116590 Chemical Gene dismutase|conj|START_ENTITY reversed|nmod|dismutase decreased|ccomp|reversed decreased|nsubj|phosphorylation phosphorylation|amod|2 2|dep|END_ENTITY After 3-4 days of IH , extracellular_signal-regulated_kinases_1 / 2 -LRB- ERK1/2 -RRB- protein phosphorylation decreased , which could be reversed by superoxide dismutase -LRB- SOD -RRB- , 1,10-phenanthroline -LRB- Phe -RRB- , the PP2A phosphorylation inhibitors , okadaic_acid -LRB- OKA -RRB- and cantharidin , and the ERK phosphorylation activator nicotine -LRB- p < 0.05 -RRB- . 15560890 8 1,10-phenanthroline 1076,1095 E-selectin 1154,1164 1,10-phenanthroline E-selectin MESH:C025205 6401 Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|ICAM-1 ICAM-1|conj|END_ENTITY In contrast , the non-antioxidant metal chelator 1,10-phenanthroline partially suppressed the surface expression of ICAM-1 and E-selectin . 7773548 7 1,10-phenanthroline 1141,1160 ET-1 1107,1111 1,10-phenanthroline ET-1 MESH:C025205 24323(Tax:10116) Chemical Gene prevented|nmod|START_ENTITY prevented|nsubjpass|degradation degradation|nmod|END_ENTITY The degradation of ET-1 by recirc-K was prevented by 1,10-phenanthroline -LRB- 10 -LRB- -3 -RRB- M -RRB- , abolished by heating the recirc-K solution to 90 degrees C for 15 min , and reduced by EGTA -LRB- 5 x 10 -LRB- -3 -RRB- M -RRB- or ET-1 -LRB- 16-21 -RRB- -LRB- 10 -LRB- -5 -RRB- M -RRB- . 7773548 7 1,10-phenanthroline 1141,1160 ET-1 1282,1286 1,10-phenanthroline ET-1 MESH:C025205 24323(Tax:10116) Chemical Gene prevented|nmod|START_ENTITY prevented|conj|reduced reduced|nmod|EGTA EGTA|conj|END_ENTITY The degradation of ET-1 by recirc-K was prevented by 1,10-phenanthroline -LRB- 10 -LRB- -3 -RRB- M -RRB- , abolished by heating the recirc-K solution to 90 degrees C for 15 min , and reduced by EGTA -LRB- 5 x 10 -LRB- -3 -RRB- M -RRB- or ET-1 -LRB- 16-21 -RRB- -LRB- 10 -LRB- -5 -RRB- M -RRB- . 1959454 1 1,10-phenanthroline 213,232 Fab 104,107 1,10-phenanthroline Fab MESH:C025205 2187 Chemical Gene modified|conj|START_ENTITY modified|nsubj|site site|nmod|fragment fragment|compound|END_ENTITY The binding site of the Fab fragment of antibody MOPC315 was chemically modified with cyclam _ -LRB- 1,4,8,11-tetraazacyclotetradecane -RRB- and 1,10-phenanthroline . 15248789 1 1,10-phenanthroline 272,291 fac 207,210 1,10-phenanthroline fac MESH:C025205 2176 Chemical Gene reported|conj|START_ENTITY reported|nmod|series series|nmod|END_ENTITY Photochemical and photophysical data are reported for a series of fac - -LSB- Mn -LRB- CO -RRB- -LRB- 3 -RRB- -LRB- phen -RRB- -LRB- Im-R -RRB- -RSB- -LRB- SO -LRB- 3 -RRB- CF -LRB- 3 -RRB- -RRB- complexes , where phen is 1,10-phenanthroline and Im is imidazole . 12175619 7 1,10-phenanthroline 1378,1397 fibrinogen 1175,1185 1,10-phenanthroline fibrinogen MESH:C025205 2244 Chemical Gene blocked|advcl|START_ENTITY event|acl|blocked gel|appos|event ran|nmod|gel fragments|acl:relcl|ran generating|dobj|fragments different|xcomp|generating different|advcl|incubated incubated|nsubjpass|END_ENTITY In addition , when purified fibrinogen was incubated with L. intermedia abdominal extract , the fibrinogenolysis was completely different , generating low mass fragments that ran away from the gel , a proteolytic event not blocked by 1,10-phenanthroline . 15567466 5 1,10-phenanthroline 725,744 fibrinogen 658,668 1,10-phenanthroline fibrinogen MESH:C025205 2244 Chemical Gene inhibited|advcl|START_ENTITY able|conj|inhibited able|xcomp|cleave cleave|dobj|chains chains|nmod|END_ENTITY SCE was able to cleave all chains of fibrinogen and fibrin and the cleavage was completely inhibited by 1,10-phenanthroline , suggesting an essential role for metalloprotease -LRB- s -RRB- in this process . 10504442 3 1,10-phenanthroline 472,491 fibronectin 632,643 1,10-phenanthroline fibronectin MESH:C025205 2335 Chemical Gene dermal-epidermal_separation|amod|START_ENTITY dermal-epidermal_separation|conj|disappearance disappearance|dep|region region|nmod|END_ENTITY Tryptase caused , in the presence and absence of 1,10-phenanthroline , focal dermal-epidermal_separation above laminin and almost complete disappearance of the staining of the extra domain A region of cellular fibronectin in and beneath the basement membrane . 17535156 7 1,10-phenanthroline 1298,1317 fibronectin 1205,1216 1,10-phenanthroline fibronectin MESH:C025205 2335 Chemical Gene presence|nmod|START_ENTITY inhibited|nmod|presence resulted|parataxis|inhibited resulted|nmod|de-adhesion de-adhesion|conj|degradation degradation|nmod|END_ENTITY LALP addition to endothelial cell cultures resulted in de-adhesion of the cells , and also in the degradation of fibronectin and fibrinogen -LRB- this could be inhibited by the presence of the bivalent chelator 1,10-phenanthroline -RRB- and of gelatin in vitro . 2549171 8 1,10-phenanthroline 1693,1712 fibronectin 1601,1612 1,10-phenanthroline fibronectin MESH:C025205 2335 Chemical Gene inhibitors|amod|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|degradation degradation|compound|END_ENTITY In addition , formation of the rosette contact is insensitive to the ionophore monensin , and to inhibitors of proteolytic enzymes , while local fibronectin degradation at rosette contacts is inhibited by inhibitors of metalloproteases , 1,10-phenanthroline and NP-20 . 6325472 8 1,10-phenanthroline 1687,1706 fibronectin 1853,1864 1,10-phenanthroline fibronectin MESH:C025205 2335 Chemical Gene inhibited|advcl|START_ENTITY inhibited|nmod|concentrations concentrations|acl:relcl|affect affect|advcl|supporting supporting|dobj|role role|nmod|proteases proteases|nmod|degradation degradation|nmod|substratum substratum|compound|END_ENTITY However , both the release of radiolabeled peptides and the appearance of fluorescence-negative spots were inhibited by 1,10-phenanthroline at concentrations that did not affect cellular attachment and protein synthesis , thus supporting a role for proteases in localized degradation of fibronectin substratum . 8769737 5 1,10-phenanthroline 1272,1291 GAPDH 1330,1335 1,10-phenanthroline GAPDH MESH:C025205 100009074(Tax:9986) Chemical Gene prevented|nsubj|START_ENTITY prevented|nmod|levels levels|amod|END_ENTITY The cell.permeable iron chelator 1,10-phenanthroline completely prevented the increases in GAPDH mRNA levels induced by DDC . 26505793 0 1,10-phenanthroline 33,52 GLP-1 0,5 1,10-phenanthroline GLP-1 MESH:C025205 2641 Chemical Gene stimulated|nmod|START_ENTITY stimulated|nsubjpass|secretion secretion|compound|END_ENTITY GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell . 26505793 4 1,10-phenanthroline 760,779 GLP-1 677,682 1,10-phenanthroline GLP-1 MESH:C025205 2641 Chemical Gene secreted|nmod|START_ENTITY secreted|nsubjpass|hormone hormone|compound|END_ENTITY We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- . 26505793 5 1,10-phenanthroline 1043,1062 GLP-1 1082,1087 1,10-phenanthroline GLP-1 MESH:C025205 2641 Chemical Gene ligand|conj|START_ENTITY able|csubj|ligand able|xcomp|secrete secrete|dobj|hormone hormone|compound|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 5 1,10-phenanthroline 911,930 GLP-1 1082,1087 1,10-phenanthroline GLP-1 MESH:C025205 2641 Chemical Gene used|dobj|START_ENTITY used|advcl|able able|xcomp|secrete secrete|dobj|hormone hormone|compound|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 6 1,10-phenanthroline 1282,1301 GLP-1 1185,1190 1,10-phenanthroline GLP-1 MESH:C025205 2641 Chemical Gene secreted|nmod|START_ENTITY colocalized|conj|secreted colocalized|nsubjpass|hormone hormone|compound|END_ENTITY Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells . 12110545 3 1,10-phenanthroline 606,625 GLUT4 548,553 1,10-phenanthroline GLUT4 MESH:C025205 25139(Tax:10116) Chemical Gene suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activated|nsubjpass|transfer transfer|compound|END_ENTITY The in vitro GLUT4 transfer was activated and inhibited by suramin and 1,10-phenanthroline -LRB- an activator and an inhibitor of GPI-PLD activity , respectively -RRB- . 14522962 2 1,10-phenanthroline 274,293 glutaminyl_cyclase 140,158 1,10-phenanthroline glutaminyl cyclase MESH:C025205 25797 Chemical Gene chelators|amod|START_ENTITY suggested|nmod|chelators identified|advcl|suggested identified|nsubjpass|END_ENTITY Human glutaminyl_cyclase -LRB- QC -RRB- was identified as a metalloenzyme as suggested by the time-dependent inhibition by the heterocyclic chelators 1,10-phenanthroline and dipicolinic_acid . 9180259 0 1,10-phenanthroline 39,58 glutathione_synthetase 13,35 1,10-phenanthroline glutathione synthetase MESH:C025205 14854(Tax:10090) Chemical Gene Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY Induction of glutathione_synthetase by 1,10-phenanthroline . 8658562 6 1,10-phenanthroline 1121,1140 glyceraldehyde-3-phosphate_dehydrogenase 1064,1104 1,10-phenanthroline glyceraldehyde-3-phosphate dehydrogenase MESH:C025205 108351137 Chemical Gene activated|advcl|START_ENTITY activated|nsubjpass|END_ENTITY The purified cytosolic enzymes lactate dehydrogenase and glycerol-3-phosphate_dehydrogenase are inhibited while purified glyceraldehyde-3-phosphate_dehydrogenase is activated by 1,10-phenanthroline . 8658562 6 1,10-phenanthroline 1121,1140 glycerol-3-phosphate_dehydrogenase 1000,1034 1,10-phenanthroline glycerol-3-phosphate dehydrogenase MESH:C025205 60666(Tax:10116) Chemical Gene activated|advcl|START_ENTITY inhibited|advcl|activated inhibited|nsubj|lactate lactate|amod|dehydrogenase dehydrogenase|conj|END_ENTITY The purified cytosolic enzymes lactate dehydrogenase and glycerol-3-phosphate_dehydrogenase are inhibited while purified glyceraldehyde-3-phosphate_dehydrogenase is activated by 1,10-phenanthroline . 15146242 4 1,10-phenanthroline 841,860 GM6001 786,792 1,10-phenanthroline GM6001 MESH:C025205 546949(Tax:10090) Chemical Gene chelator|dep|START_ENTITY injection|conj|chelator injection|nmod|END_ENTITY Gelatinolytic activity was detected earliest within the matrix of cortical blood vessels and later within neurons and pia arachnoid -LRB- > or = 3 hours -RRB- , particularly within piriform cortex ; this activity was suppressed by injection of the metalloprotease inhibitor GM6001 or in vitro by the addition of a zinc chelator -LRB- 1,10-phenanthroline -RRB- . 14611645 9 1,10-phenanthroline 1537,1556 GPI-PLD 1560,1567 1,10-phenanthroline GPI-PLD MESH:C025205 2822 Chemical Gene START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY Furthermore , 1,10-phenanthroline , a GPI-PLD inhibitor , reversed this effect . 15893415 5 1,10-phenanthroline 732,751 GPI-PLD 793,800 1,10-phenanthroline GPI-PLD MESH:C025205 2822 Chemical Gene suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activate|parataxis|activated activate|dobj|activity activity|amod|END_ENTITY Furthermore , CEA release could be activated and inhibited by incubation of LS180 cells with suramin and 1,10-phenanthroline , compounds known to activate and inhibit GPI-PLD activity , respectively . 17467053 7 1,10-phenanthroline 1127,1146 GPI-PLD 1164,1171 1,10-phenanthroline GPI-PLD MESH:C025205 2822 Chemical Gene START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment . 7512501 6 1,10-phenanthroline 1118,1137 GPI-PLD 1155,1162 1,10-phenanthroline GPI-PLD MESH:C025205 2822 Chemical Gene cells|nmod|START_ENTITY Treatment|nmod|cells Treatment|appos|inhibitor inhibitor|nmod|END_ENTITY Treatment of HeLa cells with 1,10-phenanthroline , an inhibitor of GPI-PLD , reduced the release of -LSB- 3H -RSB- ethanolamine-DAF by 70 % . 10807918 6 1,10-phenanthroline 1312,1331 HB-EGF 1151,1157 1,10-phenanthroline HB-EGF MESH:C025205 1839 Chemical Gene -RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nmod|mechanism mechanism|nmod|release release|nmod|heparin-binding_EGF heparin-binding_EGF|appos|END_ENTITY Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline . 10807918 6 1,10-phenanthroline 1312,1331 HB-EGF 1270,1276 1,10-phenanthroline HB-EGF MESH:C025205 1839 Chemical Gene -RSB-|conj|START_ENTITY -RSB-|conj|inhibitor inhibitor|nmod|END_ENTITY Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline . 10807918 6 1,10-phenanthroline 1312,1331 heparin-binding_EGF 1130,1149 1,10-phenanthroline heparin-binding EGF MESH:C025205 1839 Chemical Gene -RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nmod|mechanism mechanism|nmod|release release|nmod|END_ENTITY Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline . 16503297 4 1,10-phenanthroline 467,486 Hg2 458,461 1,10-phenanthroline Hg2 MESH:C025205 283955 Chemical Gene inhibited|conj|START_ENTITY inhibited|conj|+ +|advmod|END_ENTITY The purified enzyme had a molecular mass of 55 kDa and a pI 5.8 , and the hydrolase activity was strongly inhibited by EDTA , dithiothreitol -LRB- DTT -RRB- , Hg2 + and 1,10-phenanthroline . 17190448 7 1,10-phenanthroline 1242,1261 HIF-1 1271,1276 1,10-phenanthroline HIF-1 MESH:C025205 3091 Chemical Gene chelator|dep|START_ENTITY chelator|conj|activation activation|compound|END_ENTITY Sodwanone V -LRB- 8 -RRB- inhibited both hypoxia-induced and iron chelator -LRB- 1,10-phenanthroline -RRB- - induced HIF-1 activation in T47D breast_tumor cells -LRB- IC50 15 microM -RRB- , and 8 was the only sodwanone that inhibited HIF-1 activation in PC-3 prostate_tumor cells -LRB- IC50 15 microM -RRB- . 18586877 13 1,10-phenanthroline 1315,1334 HIF-1alpha 1364,1374 1,10-phenanthroline HIF-1alpha MESH:C025205 15251(Tax:10090) Chemical Gene chelator|appos|START_ENTITY injection|nmod|chelator prevented|nsubj|injection prevented|dobj|degradation degradation|nmod|END_ENTITY Systemic injection of the iron chelator , 1,10-phenanthroline prevented the degradation of HIF-1alpha and reduced oxygen-induced proliferation . 10360838 8 1,10-phenanthroline 1016,1035 HMP1 992,996 1,10-phenanthroline HMP1 MESH:C025205 10531 Chemical Gene inactivated|nmod|START_ENTITY inactivated|nsubjpass|END_ENTITY HMP1 was inactivated by 1,10-phenanthroline , a specific inhibitor of Zn -LRB- +2 -RRB- - dependent metalloproteases . 20888885 4 1,10-phenanthroline 864,883 HO-1 749,753 1,10-phenanthroline HO-1 MESH:C025205 15368(Tax:10090) Chemical Gene SO|amod|START_ENTITY scavengers|nmod|SO suppressed|nmod|scavengers suppressed|nsubjpass|expression expression|compound|END_ENTITY Interestingly , the raloxifene-induced HO-1 expression was suppressed by reactive oxygen species -LRB- ROS -RRB- scavengers , including glutathione , TEMPO , Me -LRB- 2 -RRB- SO , 1,10-phenanthroline , or allopurinol . 1938939 4 1,10-phenanthroline 599,618 HSC82 792,797 1,10-phenanthroline HSC82 MESH:C025205 855224(Tax:4932) Chemical Gene intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|END_ENTITY Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- . 1938939 4 1,10-phenanthroline 599,618 HSP26 805,810 1,10-phenanthroline HSP26 MESH:C025205 852364(Tax:4932) Chemical Gene intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|HSC82 HSC82|dep|END_ENTITY Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- . 8530397 2 1,10-phenanthroline 357,376 HSP_70 346,352 1,10-phenanthroline HSP 70 MESH:C025205 3308 Chemical Gene synthesis|amod|START_ENTITY studied|nmod|synthesis studied|parataxis|homolog homolog|nmod|END_ENTITY This investigation studied the pharmacological induction of HSP 68 -LRB- HSP 68 is the rat homolog of human HSP_70 -RRB- by 1,10-phenanthroline in cultured rat astrocytes under conditions that activated heat_shock transcription factor-1 without inducing HSP 68 synthesis . 10069381 3 1,10-phenanthroline 386,405 hsp72 419,424 1,10-phenanthroline hsp72 MESH:C025205 3303 Chemical Gene pyrrolidine_dithiocarbamate|conj|START_ENTITY induction|amod|pyrrolidine_dithiocarbamate induction|nmod|END_ENTITY In the presence of the antioxidant molecules pyrrolidine_dithiocarbamate or 1,10-phenanthroline induction of hsp72 and 27 was significantly decreased , while N-acetyl-L-cysteine caused a slight reduction . 1938939 4 1,10-phenanthroline 599,618 HSP82 750,755 1,10-phenanthroline HSP82 MESH:C025205 855836(Tax:4932) Chemical Gene intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|END_ENTITY Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- . 15560890 8 1,10-phenanthroline 1076,1095 ICAM-1 1143,1149 1,10-phenanthroline ICAM-1 MESH:C025205 3383 Chemical Gene suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|END_ENTITY In contrast , the non-antioxidant metal chelator 1,10-phenanthroline partially suppressed the surface expression of ICAM-1 and E-selectin . 7494830 4 1,10-phenanthroline 638,657 IDE 604,607 1,10-phenanthroline IDE MESH:C025205 3416 Chemical Gene N-ethylmaleimide|dep|START_ENTITY inhibitors|appos|N-ethylmaleimide inhibitors|compound|END_ENTITY Cytosolic insulin-degrading activity had a pH optimum of 7.5 , was almost completely inhibited by IDE inhibitors -LRB- N-ethylmaleimide , 1,10-phenanthroline , EDTA , p-chloromercuribenzoate , bacitracin -RRB- , but was not or only weakly inhibited by others -LRB- aprotinin , chymostatin , leupeptin , and diisopropyl_phosphofluoridate . -RRB- 7596985 4 1,10-phenanthroline 637,656 IDE 593,596 1,10-phenanthroline IDE MESH:C025205 3416 Chemical Gene N-ethylmaleimide|conj|START_ENTITY inhibitors|nmod|N-ethylmaleimide inhibitors|compound|END_ENTITY Cytosolic insulin degradation was strongly inhibited by IDE inhibitors , including N-ethylmaleimide , 1,10-phenanthroline , p-chloromericuribenzoate , and EDTA , but was not significantly or not as extensively inhibited by strong inhibitors of proteasome , i.e. , chymostatin , soybean trypsin inhibitor , leupeptin , and Dip-F . 7789307 7 1,10-phenanthroline 1224,1243 IDE 1191,1194 1,10-phenanthroline IDE MESH:C025205 3416 Chemical Gene inhibited|advcl|START_ENTITY inhibited|nsubjpass|activity activity|amod|insulin-degrading_enzyme insulin-degrading_enzyme|dep|END_ENTITY When cytoplasmic insulin-degrading_enzyme -LRB- IDE -RRB- activity was inhibited with 1,10-phenanthroline , an increase in the number of cytoplasmic and nuclear Nanogold-insulin particles was observed . 8504733 5 1,10-phenanthroline 816,835 IDE 806,809 1,10-phenanthroline IDE MESH:C025205 25700(Tax:10116) Chemical Gene cells|amod|START_ENTITY insulin_degrading_enzyme|nmod|cells insulin_degrading_enzyme|appos|END_ENTITY We examined the effects of inhibiting insulin_degrading_enzyme -LRB- IDE -RRB- with 1,10-phenanthroline on the nuclear accumulation of insulin in H35 cells . 10807918 6 1,10-phenanthroline 1312,1331 IGF-1 1009,1014 1,10-phenanthroline IGF-1 MESH:C025205 3479 Chemical Gene -RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nsubjpass|talk talk|nmod|receptors receptors|compound|END_ENTITY Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline . 15013428 4 1,10-phenanthroline 779,798 IGFBP-3 674,681 1,10-phenanthroline IGFBP-3 MESH:C025205 3486 Chemical Gene EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|dobj|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 11768717 7 1,10-phenanthroline 1198,1217 IGFBP-4 1152,1159 1,10-phenanthroline IGFBP-4 MESH:C025205 360622(Tax:10116) Chemical Gene inhibited|conj|START_ENTITY inhibited|nsubj|proteolysis proteolysis|compound|END_ENTITY IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I . 11867336 6 1,10-phenanthroline 1456,1475 IGFBP-4 1166,1173 1,10-phenanthroline IGFBP-4 MESH:C025205 360622(Tax:10116) Chemical Gene inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance collected|advcl|showed CM|acl|collected examined|nmod|CM examined|nsubjpass|proteolysis proteolysis|compound|END_ENTITY IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline . 11867336 6 1,10-phenanthroline 1456,1475 IGFBP-4 1416,1423 1,10-phenanthroline IGFBP-4 MESH:C025205 360622(Tax:10116) Chemical Gene inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited abundance|compound|END_ENTITY IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline . 7531715 10 1,10-phenanthroline 2053,2072 IGFBP-4 1836,1843 1,10-phenanthroline IGFBP-4 MESH:C025205 3487 Chemical Gene prevented|xcomp|START_ENTITY time|conj|prevented time|nmod|levels levels|compound|END_ENTITY The effects of IGFs on IGFBP-4 levels in this cell-free system were time , temperature , and pH dependent and were prevented by the serine proteinase inhibitor , aprotinin , by the divalent cation chelator , EDTA , and by the metal ion chelator , 1,10-phenanthroline . 11768717 7 1,10-phenanthroline 1198,1217 IGF-I 1257,1262 1,10-phenanthroline IGF-I MESH:C025205 24482(Tax:10116) Chemical Gene inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|nmod|END_ENTITY IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I . 11768717 7 1,10-phenanthroline 1198,1217 IGF-I 1310,1315 1,10-phenanthroline IGF-I MESH:C025205 24482(Tax:10116) Chemical Gene inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|conj|END_ENTITY IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I . 15013428 4 1,10-phenanthroline 779,798 IGF-I 719,724 1,10-phenanthroline IGF-I MESH:C025205 3479 Chemical Gene EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|nmod|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 11768717 7 1,10-phenanthroline 1198,1217 IGF-II 1267,1273 1,10-phenanthroline IGF-II MESH:C025205 24483(Tax:10116) Chemical Gene inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|nmod|IGF-I IGF-I|conj|END_ENTITY IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I . 15013428 4 1,10-phenanthroline 779,798 IGF-II 728,734 1,10-phenanthroline IGF-II MESH:C025205 3481 Chemical Gene EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|nmod|IGF-I IGF-I|conj|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 17048265 0 1,10-phenanthroline 134,153 III 48,51 1,10-phenanthroline III MESH:C025205 4514 Chemical Gene bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|shifts shifts|nmod|gold gold|appos|END_ENTITY 1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline . 17048265 0 1,10-phenanthroline 134,153 III 61,64 1,10-phenanthroline III MESH:C025205 4514 Chemical Gene bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|cobalt cobalt|appos|END_ENTITY 1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline . 17048265 0 1,10-phenanthroline 134,153 III 75,78 1,10-phenanthroline III MESH:C025205 4514 Chemical Gene bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|cobalt cobalt|appos|rhodium rhodium|appos|END_ENTITY 1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline . 11867336 6 1,10-phenanthroline 1456,1475 IL-1beta 1303,1311 1,10-phenanthroline IL-1beta MESH:C025205 24494(Tax:10116) Chemical Gene inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance showed|nsubj|incubation incubation|nmod|medium medium|conj|END_ENTITY IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline . 10341317 13 1,10-phenanthroline 1447,1466 IL-4R 1510,1515 1,10-phenanthroline IL-4R MESH:C025205 3566 Chemical Gene dose-dependently|amod|START_ENTITY Phosphoramidon|conj|dose-dependently inhibited|nsubj|Phosphoramidon inhibited|xcomp|shedding shedding|advcl|END_ENTITY Phosphoramidon and 1,10-phenanthroline dose-dependently inhibited shedding of the IL-4R , even in nonactivated T cells . 9376127 5 1,10-phenanthroline 775,794 IL-5 753,757 1,10-phenanthroline IL-5 MESH:C025205 3567 Chemical Gene chymostatin|amod|START_ENTITY inhibited|nmod|chymostatin inhibited|nsubjpass|transmigration transmigration|nmod|eosinophils eosinophils|acl|induced induced|nmod|PAF PAF|conj|END_ENTITY Matrigel transmigration of eosinophils induced by PAF and IL-5 was inhibited by 1,10-phenanthroline , batimastat , 3,4-dichloroisocoumarin , chymostatin , and a neutralizing antibody for the matrix_metalloproteinase _ -LRB- MMP -RRB- -9 , indicating that serine proteinase -LRB- s -RRB- and MMP , specifically MMP-9 , were involved in the transmigration of eosinophils through Matrigel . 8024692 2 1,10-phenanthroline 467,486 insulin 566,573 1,10-phenanthroline insulin MESH:C025205 3630 Chemical Gene enzyme|nmod|START_ENTITY inhibition|nmod|enzyme caused|nsubj|inhibition caused|nmod|accumulation accumulation|nmod|END_ENTITY In a recent study , inhibition of insulin-degrading enzyme with 1,10-phenanthroline , a Zn2 + chelator , caused a significant increase in the nuclear accumulation of insulin . 8024692 3 1,10-phenanthroline 622,641 insulin 694,701 1,10-phenanthroline insulin MESH:C025205 3630 Chemical Gene effects|nmod|START_ENTITY effects|conj|isomer isomer|nmod|degradation degradation|compound|END_ENTITY The present study characterized the effects of 1,10-phenanthroline and its nonchelating isomer , 1,7-phenanthroline , on insulin degradation , nuclear accumulation , and stimulation of immediate-early gene expression . 8024692 6 1,10-phenanthroline 1161,1180 insulin 1120,1127 1,10-phenanthroline insulin MESH:C025205 3630 Chemical Gene tested|nsubj|START_ENTITY revealed|ccomp|tested revealed|nmod|presence presence|nmod|END_ENTITY In the presence of insulin , Northern analysis revealed that 1,10-phenanthroline at all concentrations tested increased alpha-tubulin mRNA levels , but had a biphasic effect on insulin-stimulated immediate-early gene expression . 8504733 5 1,10-phenanthroline 816,835 insulin_degrading_enzyme 780,804 1,10-phenanthroline insulin degrading enzyme MESH:C025205 25700(Tax:10116) Chemical Gene cells|amod|START_ENTITY END_ENTITY|nmod|cells We examined the effects of inhibiting insulin_degrading_enzyme -LRB- IDE -RRB- with 1,10-phenanthroline on the nuclear accumulation of insulin in H35 cells . 7789307 7 1,10-phenanthroline 1224,1243 insulin-degrading_enzyme 1165,1189 1,10-phenanthroline insulin-degrading enzyme MESH:C025205 3416 Chemical Gene inhibited|advcl|START_ENTITY inhibited|nsubjpass|activity activity|amod|END_ENTITY When cytoplasmic insulin-degrading_enzyme -LRB- IDE -RRB- activity was inhibited with 1,10-phenanthroline , an increase in the number of cytoplasmic and nuclear Nanogold-insulin particles was observed . 8953512 3 1,10-phenanthroline 573,592 insulin-degrading_enzyme 519,543 1,10-phenanthroline insulin-degrading enzyme MESH:C025205 25700(Tax:10116) Chemical Gene N-ethylmaleimide|amod|START_ENTITY inhibit|nmod|N-ethylmaleimide inhibit|xcomp|END_ENTITY Inhibitors that inhibit insulin-degrading_enzyme , including N-ethylmaleimide , 1,10-phenanthroline and p-chloromercuribenzoate , dramatically improved insulin transport across the ileum . 15013428 4 1,10-phenanthroline 779,798 insulin-like_growth_factor_binding_protein-3 628,672 1,10-phenanthroline insulin-like growth factor binding protein-3 MESH:C025205 3486 Chemical Gene EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|dobj|IGFBP-3 IGFBP-3|amod|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 24136115 8 1,10-phenanthroline 1542,1561 JAK_2 1570,1575 1,10-phenanthroline JAK 2 MESH:C025205 3717 Chemical Gene inhibitor|appos|START_ENTITY inhibitor|nmod|inhibitor inhibitor|compound|END_ENTITY The MMP-2 platelet activation pathway can be synergistically inhibited with the non-selective MMP inhibitor , 1,10-phenanthroline , plus a JAK_2 inhibitor . 17680773 9 1,10-phenanthroline 1673,1692 JNK 1750,1753 1,10-phenanthroline JNK MESH:C025205 5599 Chemical Gene CQ|conj|START_ENTITY -LSB-|dobj|CQ inhibited|ccomp|-LSB- ligands|acl:relcl|inhibited induced|nsubj|ligands induced|dobj|activation activation|nmod|PI3K PI3K|conj|END_ENTITY Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta . 7594568 6 1,10-phenanthroline 853,872 KIR 1053,1056 1,10-phenanthroline KIR MESH:C025205 3805 Chemical Gene chelator|amod|START_ENTITY addition|nmod|chelator reversed|nsubj|addition reversed|advcl|demonstrating demonstrating|ccomp|necessary necessary|nmod|function function|nmod|END_ENTITY Furthermore , addition of the zinc chelator 1,10-phenanthroline during chromium release assays reversed the inhibition of killing by NK clones specific for HLA-Cw4 or HLA-Cw8 , demonstrating that zinc is necessary for the inhibitory function of KIR . 12568801 6 1,10-phenanthroline 1121,1140 LAP 959,962 1,10-phenanthroline LAP MESH:C025205 51056 Chemical Gene metals|conj|START_ENTITY inhibited|nsubj|metals C.|acl:relcl|inhibited active|dep|C. active|advcl|C C|nsubj|temperature temperature|nmod|activity activity|compound|END_ENTITY Although the optimal temperature of LAP activity was 40 degrees C , the enzyme was active over a broad temperature range from 2 to 60 degrees C. Among a number of inhibitors tested , heavy metals and 1,10-phenanthroline completely inhibited the enzyme , while methanol , ethanol and EGTA stimulated somewhat LAP activity . 18155948 4 1,10-phenanthroline 627,646 LAP 741,744 1,10-phenanthroline LAP MESH:C025205 51056 Chemical Gene START_ENTITY|advcl|END_ENTITY Among a number of inhibitors tested , the most efficient were 1,10-phenanthroline having a K -LRB- i -RRB- value of 0.12 mM and cysteine with K -LRB- i -RRB- value of 0.31 mM , while EGTA stimulated LAP activity . 20417561 6 1,10-phenanthroline 711,730 Lck 617,620 1,10-phenanthroline Lck MESH:C025205 3932 Chemical Gene inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited END_ENTITY|nmod|interaction CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline . 20417561 7 1,10-phenanthroline 826,845 Lck 873,876 1,10-phenanthroline Lck MESH:C025205 3932 Chemical Gene presence|nmod|START_ENTITY abolished|nmod|presence show|ccomp|abolished show|conj|reduced reduced|nsubj|association association|nmod|END_ENTITY Here we show that both CD4 and CD44-mediated T cell spreading is abolished in the presence of 1,10-phenanthroline and their association with Lck is significantly reduced . 2244921 4 1,10-phenanthroline 674,693 leukotriene_A4_hydrolase 614,638 1,10-phenanthroline leukotriene A4 hydrolase MESH:C025205 4048 Chemical Gene removed|nmod|START_ENTITY removed|nsubjpass|atom atom|nmod|END_ENTITY The zinc atom of leukotriene_A4_hydrolase can be removed by dialysis against 1,10-phenanthroline which results in loss of enzyme activity . 3519317 1 1,10-phenanthroline 568,587 LHRH 613,617 1,10-phenanthroline LHRH MESH:C025205 25194(Tax:10116) Chemical Gene reagents|conj|START_ENTITY reagents|conj|analogues analogues|compound|END_ENTITY The peptidase was inhibited by sulphydryl reagents , TLCK , 1,10-phenanthroline , EDTA , bacitracin , other LHRH analogues , oxytocin , -LSB- Lys8 -RSB- vasopressin and somatostatin . 7507963 4 1,10-phenanthroline 395,414 L-selectin 628,638 1,10-phenanthroline L-selectin MESH:C025205 6402 Chemical Gene inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|conj|cleavage cleavage|nmod|END_ENTITY Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes . 15034049 6 1,10-phenanthroline 1098,1117 MASP-3 1197,1203 1,10-phenanthroline MASP-3 MESH:C025205 5648 Chemical Gene iodoacetamide|conj|START_ENTITY inhibitors|amod|iodoacetamide presence|nmod|inhibitors prevented|nmod|presence prevented|conj|abolished abolished|nmod|Ser Ser|nmod|END_ENTITY Activation was prevented in the presence of protease inhibitors iodoacetamide and 1,10-phenanthroline but was not abolished upon substitution of Ala for the active site Ser -LRB- 645 -RRB- of MASP-3 , indicating extrinsic proteolysis . 9267436 2 1,10-phenanthroline 511,530 Mbr1p 318,323 1,10-phenanthroline Mbr1p MESH:C025205 853769(Tax:4932) Chemical Gene presence|nmod|START_ENTITY conditions|conj|presence factor|nmod|conditions factor|nsubj|END_ENTITY In this paper , we show that Mbr1p is a limiting factor for growth on glycerol medium under the following sub-optimal culture conditions : in late growth phase , at low temperature , at high external pH or in the presence of 1,10-phenanthroline . 14575869 6 1,10-phenanthroline 1058,1077 MEK 1108,1111 1,10-phenanthroline MEK MESH:C025205 5609 Chemical Gene MAPK|nmod|START_ENTITY phosphorylation|nmod|MAPK depends|nsubj|phosphorylation depends|nmod|interaction interaction|nmod|END_ENTITY Our results suggest that phosphorylation of MAPK by 1,10-phenanthroline depends on the interaction of MEK . 1335413 4 1,10-phenanthroline 1056,1075 metalloendopeptidase 1168,1188 1,10-phenanthroline metalloendopeptidase MESH:C025205 64517(Tax:10116) Chemical Gene inhibition|nmod|START_ENTITY suggests|nsubj|inhibition suggests|dobj|contribution contribution|nmod|one one|amod|END_ENTITY Its inhibition by 1,10-phenanthroline , EDTA and bacitracin but not by thiorphan suggests the contribution of at least one neutral metalloendopeptidase , distinct from EC 3.4.24.11 , for which ANP showed high affinity . 9882532 9 1,10-phenanthroline 1651,1670 metalloproteinase 1695,1712 1,10-phenanthroline metalloproteinase MESH:C025205 547880(Tax:3847) Chemical Gene START_ENTITY|conj|END_ENTITY Similarly , incubating injured tissues in either 1,10-phenanthroline or phosphoramidon , both metalloproteinase inhibitors , did not prevent endothelial cell movement nor wound repair . 9344851 6 1,10-phenanthroline 924,943 mGPDH 799,804 1,10-phenanthroline mGPDH MESH:C025205 14571(Tax:10090) Chemical Gene inhibited|conj|START_ENTITY was|advmod|inhibited was|nsubj|activation activation|nmod|END_ENTITY The AA activation of mGPDH was likewise completely inhibited by iron specific chelators , bathophenanthrolinedisulfonic_acid , desferrioxamine , and 1,10-phenanthroline , but the activation could not be restored by the addition of excess Ca2 + . 16814470 4 1,10-phenanthroline 705,724 MMP 690,693 1,10-phenanthroline MMP MESH:C025205 100194417(Tax:3847) Chemical Gene inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY The conditioned media from cell-mediated collagen degradation assays were incubated with Type I collagen at pH 7.5 with or without a MMP inhibitor -LRB- 1,10-phenanthroline -RRB- , serine proteinase inhibitors -LRB- alpha1-antitrypsin and soybean trypsin inhibitor , STI -RRB- , or cysteine proteinase inhibitors . 19136476 10 1,10-phenanthroline 1540,1559 MMP-1 1443,1448 1,10-phenanthroline MMP-1 MESH:C025205 4312 Chemical Gene blocked|parataxis|START_ENTITY blocked|nsubjpass|upregulation upregulation|nmod|expression expression|compound|END_ENTITY 15d-PGJ2-mediated upregulation of MMP-1 expression was blocked by the iron chelator desferrioxamine and the Fe2 + - specific chelator 1,10-phenanthroline . 24136115 4 1,10-phenanthroline 710,729 MMP-1 751,756 1,10-phenanthroline MMP-1 MESH:C025205 4312 Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY In vitro analysis demonstrated that 1,10-phenanthroline completely inhibited MMP-1 ,2 , and 9 but had little to no effect on calpain activity while the converse was true with AEBSF . 8045973 5 1,10-phenanthroline 974,993 MMP-1 796,801 1,10-phenanthroline MMP-1 MESH:C025205 4312 Chemical Gene confirmed|conj|START_ENTITY confirmed|nsubj|Identities Identities|nmod|END_ENTITY Identities of MMP-1 and MMP-3 were confirmed by Western blots , by comparison of mol wt with those of purified enzymes on casein zymography , and by inhibition of these activities with EDTA and 1,10-phenanthroline . 12047435 9 1,10-phenanthroline 1301,1320 MMP-2 1402,1407 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene attenuated|nsubj|START_ENTITY attenuated|advcl|increased increased|nsubj|addition addition|nmod|exogenous exogenous|acl|purified purified|xcomp|END_ENTITY The MMP inhibitor 1,10-phenanthroline attenuated the increased proliferation , while the addition of exogenous purified MMP-2 alone also increased fibroblast proliferation . 14732714 10 1,10-phenanthroline 1804,1823 MMP-2 1677,1682 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene -1|conj|START_ENTITY inhibited|nmod|-1 inhibited|nsubjpass|M392L M392L|amod|END_ENTITY -LRB- M392L -RRB- MMP-2 and -LRB- M392S -RRB- MMP-2 were inhibited by tissue_inhibitor_of_metalloproteinases _ -LRB- TIMP -RRB- -1 , _ -2 , _ and _ -4 and by the zinc chelators 1,10-phenanthroline and a synthetic hydroxamate inhibitor , Batimastat , similar to the wild-type protein , indicating an unaltered active site topography . 14732714 10 1,10-phenanthroline 1804,1823 MMP-2 1694,1699 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene -1|conj|START_ENTITY inhibited|nmod|-1 inhibited|nsubjpass|M392L M392L|amod|MMP-2 END_ENTITY|conj|MMP-2 -LRB- M392L -RRB- MMP-2 and -LRB- M392S -RRB- MMP-2 were inhibited by tissue_inhibitor_of_metalloproteinases _ -LRB- TIMP -RRB- -1 , _ -2 , _ and _ -4 and by the zinc chelators 1,10-phenanthroline and a synthetic hydroxamate inhibitor , Batimastat , similar to the wild-type protein , indicating an unaltered active site topography . 15095267 7 1,10-phenanthroline 1802,1821 MMP-2 1658,1663 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|END_ENTITY Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline . 24136115 8 1,10-phenanthroline 1542,1561 MMP-2 1437,1442 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene inhibitor|appos|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubj|activation activation|compound|END_ENTITY The MMP-2 platelet activation pathway can be synergistically inhibited with the non-selective MMP inhibitor , 1,10-phenanthroline , plus a JAK_2 inhibitor . 9699154 6 1,10-phenanthroline 1162,1181 MMP-2 1067,1072 1,10-phenanthroline MMP-2 MESH:C025205 4313 Chemical Gene presence|nmod|START_ENTITY inhibited|nmod|presence confirmed|conj|inhibited confirmed|nmod|A A|appos|END_ENTITY This 66 kDa MMP was confirmed as gelatinase A -LRB- MMP-2 -RRB- based on the results of its activity dependent on Ca2 + and inhibited in the presence of 1,10-phenanthroline or EDTA , as well as its specific immunoreactivity on the Western blot . 8045973 5 1,10-phenanthroline 974,993 MMP-3 806,811 1,10-phenanthroline MMP-3 MESH:C025205 4314 Chemical Gene confirmed|conj|START_ENTITY confirmed|nsubj|Identities Identities|nmod|MMP-1 MMP-1|conj|END_ENTITY Identities of MMP-1 and MMP-3 were confirmed by Western blots , by comparison of mol wt with those of purified enzymes on casein zymography , and by inhibition of these activities with EDTA and 1,10-phenanthroline . 10556832 7 1,10-phenanthroline 987,1006 MMP8 1093,1097 1,10-phenanthroline MMP8 MESH:C025205 4317 Chemical Gene START_ENTITY|conj|antibody antibody|nmod|END_ENTITY Furthermore the cleavage was blocked by the metalloprotease inhibitor 1,10-phenanthroline -LRB- 70 + / - 6 % -RRB- as well as by a monoclonal antibody against human neutrophil collagenase MMP8 -LRB- 40 + / - 10 % -RRB- . 14511382 4 1,10-phenanthroline 904,923 MMP-9 794,799 1,10-phenanthroline MMP-9 MESH:C025205 4318 Chemical Gene EDTA|amod|START_ENTITY concentration|nmod|EDTA independent|nmod|concentration independent|nsubj|activation activation|nmod|complex complex|compound|END_ENTITY The calcium-induced activation and truncation of the MMP-9 / CSPG complex was independent of the concentration of the complex , inhibited by the MMP inhibitors EDTA , 1,10-phenanthroline and TIMP-1 , but not by general inhibitors of serine , thiol and acid proteinases . 9376127 5 1,10-phenanthroline 775,794 MMP-9 975,980 1,10-phenanthroline MMP-9 MESH:C025205 4318 Chemical Gene chymostatin|amod|START_ENTITY inhibited|nmod|chymostatin inhibited|conj|involved involved|nsubjpass|MMP MMP|amod|END_ENTITY Matrigel transmigration of eosinophils induced by PAF and IL-5 was inhibited by 1,10-phenanthroline , batimastat , 3,4-dichloroisocoumarin , chymostatin , and a neutralizing antibody for the matrix_metalloproteinase _ -LRB- MMP -RRB- -9 , indicating that serine proteinase -LRB- s -RRB- and MMP , specifically MMP-9 , were involved in the transmigration of eosinophils through Matrigel . 20172583 7 1,10-phenanthroline 898,917 MS2 872,875 1,10-phenanthroline MS2 MESH:C025205 100271694 Chemical Gene resulted|nsubj|START_ENTITY inhibited|advcl|resulted inhibited|dobj|inactivation inactivation|compound|END_ENTITY The addition of oxalate and humic_acids significantly inhibited the MS2 inactivation , whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2 . 20172583 7 1,10-phenanthroline 898,917 MS2 982,985 1,10-phenanthroline MS2 MESH:C025205 100271694 Chemical Gene resulted|nsubj|START_ENTITY resulted|nmod|inactivation inactivation|nmod|END_ENTITY The addition of oxalate and humic_acids significantly inhibited the MS2 inactivation , whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2 . 21726084 5 1,10-phenanthroline 906,925 MS2 1007,1010 1,10-phenanthroline MS2 MESH:C025205 100271694 Chemical Gene addition|nmod|START_ENTITY block|nsubj|addition block|dobj|inactivation inactivation|nmod|END_ENTITY First , the addition of 1,10-phenanthroline -LRB- a strong Fe -LRB- II -RRB- - chelating agent -RRB- failed to completely block the inactivation of MS2 by nZVI . 15095267 7 1,10-phenanthroline 1802,1821 MT1-MMP 1665,1672 1,10-phenanthroline MT1-MMP MESH:C025205 4323 Chemical Gene inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|MMP-2 MMP-2|conj|END_ENTITY Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline . 11404220 8 1,10-phenanthroline 1270,1289 mTOR 1091,1095 1,10-phenanthroline mTOR MESH:C025205 56718(Tax:10116) Chemical Gene incubation|nmod|START_ENTITY had|nsubj|incubation stimulated|advcl|had stimulated|nsubjpass|activities activities|nmod|END_ENTITY Furthermore , the protein kinase activities of mTOR immunoprecipitated from rat brain lysates were stimulated two - to fivefold by 10-300 microM Zn2 + in the presence of an excess of either Mn2 + or Mg2 + , whereas incubation with 1,10-phenanthroline had no effect . 25548410 5 1,10-phenanthroline 927,946 mTOR 975,979 1,10-phenanthroline mTOR MESH:C025205 2475 Chemical Gene Pretreatment|amod|START_ENTITY disappeared|nsubj|Pretreatment disappeared|dobj|cleavage cleavage|compound|END_ENTITY Pretreatment of T. _ vaginalis with a metalloproteinase inhibitor , 1,10-phenanthroline , completely disappeared the mTOR cleavage in SiHa cells . 26517723 7 1,10-phenanthroline 1149,1168 mucin 976,981 1,10-phenanthroline mucin MESH:C025205 100508689 Chemical Gene leucine|conj|START_ENTITY induce|advcl|leucine induce|nsubj|components components|nmod|END_ENTITY Seven components , including porcine gastric mucin , lincomycin , glutamine , and glucose were found to induce CFA/I surface expression in vitro in a minimal media while five others were inhibitory , including leucine and 1,10-phenanthroline . 18486963 1 1,10-phenanthroline 218,237 NaF 210,213 1,10-phenanthroline NaF MESH:C025205 3576 Chemical Gene END_ENTITY|conj|START_ENTITY The removal of Cr -LRB- VI -RRB- by zero-valent iron -LRB- Fe -LRB- 0 -RRB- -RRB- and the effect of three complex reagents , ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- , NaF and 1,10-phenanthroline , on this reaction were investigated using batch reactors at pH values of 4 , 5 and 6 . 1618157 5 1,10-phenanthroline 974,993 N-cadherin 1015,1025 1,10-phenanthroline N-cadherin MESH:C025205 1000 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|loss loss|nmod|END_ENTITY Furthermore , the metalloprotease inhibitor 1,10-phenanthroline inhibits the loss of N-cadherin from the retina . 15819038 1 1,10-phenanthroline 250,269 Nd3 205,208 1,10-phenanthroline Nd3 MESH:C025205 4537 Chemical Gene alpha-amino-acids|conj|START_ENTITY solution|amod|alpha-amino-acids +|nmod|solution complexes|conj|+ complexes|nmod|+ +|amod|END_ENTITY The absorption spectra of f-f hypersensitive transition for the complexes of Nd3 + or Er3 + with some alpha-amino-acids and 1,10-phenanthroline in 95 % ethanol solution were studied . 3681301 8 1,10-phenanthroline 1450,1469 neurotensin 1546,1557 1,10-phenanthroline neurotensin MESH:C025205 67405(Tax:10090) Chemical Gene inhibitors|amod|START_ENTITY combination|nmod|inhibitors inhibit|nsubj|combination inhibit|dobj|degradation degradation|nmod|END_ENTITY A combination of the protease inhibitors 1,10-phenanthroline and Z-Pro-Prolinal was able to inhibit almost completely the degradation of neurotensin by clone N1E-115 . 17239391 6 1,10-phenanthroline 1284,1303 NS2/3 1216,1221 1,10-phenanthroline NS2/3 MESH:C025205 57762;3845 Chemical Gene sensitive|advcl|START_ENTITY sensitive|nsubj|activity activity|compound|END_ENTITY Lastly we show that the NS2/3 auto-cleavage activity is more sensitive to zinc chelation by 1,10-phenanthroline than the NS3 protease activity . 17239391 6 1,10-phenanthroline 1284,1303 NS3 1313,1316 1,10-phenanthroline NS3 MESH:C025205 3845 Chemical Gene sensitive|advcl|START_ENTITY sensitive|nmod|activity activity|compound|END_ENTITY Lastly we show that the NS2/3 auto-cleavage activity is more sensitive to zinc chelation by 1,10-phenanthroline than the NS3 protease activity . 8853454 2 1,10-phenanthroline 467,486 nuclease 446,454 1,10-phenanthroline nuclease MESH:C025205 14568893 Chemical Gene activity|nmod|START_ENTITY activity|compound|END_ENTITY Since methyl substitution at all but the 2 and 9 positions enhances the copper-dependent chemical nuclease activity of 1,10-phenanthroline , we have compared the activity of conjugates prepared from 5 - -LRB- aminomethyl -RRB- -1,10 - phenanthroline -LRB- MOP -RRB- to those of conjugates prepared from 5-amino-1 ,10 - phenanthroline -LRB- amino-OP -RRB- . 10564652 4 1,10-phenanthroline 665,684 Occludin 595,603 1,10-phenanthroline Occludin MESH:C025205 100506658 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubj|proteolysis proteolysis|compound|END_ENTITY Occludin proteolysis was inhibited by the metalloproteinase inhibitor 1,10-phenanthroline -LRB- PHEN -RRB- , but not by inhibitors against other types of proteases . 11278521 6 1,10-phenanthroline 768,787 OLE1 696,700 1,10-phenanthroline OLE1 MESH:C025205 852825(Tax:4932) Chemical Gene presence|nmod|START_ENTITY increased|nmod|presence increased|nsubjpass|expression expression|compound|END_ENTITY OLE1 expression was also increased in the presence of the iron chelator 1,10-phenanthroline . 1581303 6 1,10-phenanthroline 968,987 oviductin 770,779 1,10-phenanthroline oviductin MESH:C025205 398108(Tax:8355) Chemical Gene iodoacetamide|conj|START_ENTITY did|nsubj|iodoacetamide inhibited|conj|did inhibited|dobj|irreversibly irreversibly|compound|END_ENTITY Diisopropyl_fluorophosphate , EDTA , and EGTA inhibited oviductin irreversibly ; soybean trypsin inhibitor , aprotinin , guanidine_hydrochloride -LRB- Ki = 7.5 mM -RRB- , and p-amino-benzamidine -LRB- Ki = 4.1 microM -RRB- also inhibited , but iodoacetamide , E-64 , pepstatin , or 1,10-phenanthroline did not . 8221671 5 1,10-phenanthroline 687,706 p53 632,635 1,10-phenanthroline p53 MESH:C025205 7157 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|nmod|protein protein|compound|END_ENTITY The DNA-binding activity of wild-type p53 hybrid protein was inhibited by the metal chelator 1,10-phenanthroline . 8467489 2 1,10-phenanthroline 337,356 p53 375,378 1,10-phenanthroline p53 MESH:C025205 7157 Chemical Gene exposure|nmod|START_ENTITY induces|nsubj|exposure induces|dobj|END_ENTITY Here we show that exposure to the metal chelator 1,10-phenanthroline induces wild-type p53 to adopt the mutant conformation and that this process is reversible . 9053835 0 1,10-phenanthroline 46,65 p53 14,17 1,10-phenanthroline p53 MESH:C025205 22060(Tax:10090) Chemical Gene transcriptional|nmod|START_ENTITY transcriptional|nsubj|Activation Activation|nmod|END_ENTITY Activation of p53 transcriptional activity by 1,10-phenanthroline , a metal chelator and redox sensitive compound . 9053835 4 1,10-phenanthroline 724,743 p53 777,780 1,10-phenanthroline p53 MESH:C025205 22060(Tax:10090) Chemical Gene has|nsubj|START_ENTITY has|dobj|effect effect|nmod|activity activity|compound|END_ENTITY The results showed that none of these in vitro active reagents , except 1,10-phenanthroline -LRB- OP -RRB- has a significant effect on p53 transactivation activity . 18961687 2 1,10-phenanthroline 399,418 PAN 505,508 1,10-phenanthroline PAN MESH:C025205 51816 Chemical Gene absence|nmod|START_ENTITY -LSB-|nmod|absence -LSB-|dobj|-RSB- -RSB-|conj|release release|nmod|END_ENTITY In the absence of 1,10-phenanthroline the rate law is expressed as - d -LSB- CuR -LRB- + -RRB- -RSB- / dt = 10 -LRB- 3.2 -RRB- -LSB- CuR -LRB- + -RRB- -LSB- Y ' -RSB- , and the release of PAN from the reaction intermediate CuRY is the rate-determining step . 15305021 5 1,10-phenanthroline 992,1011 PAP-I 1059,1064 1,10-phenanthroline PAP-I MESH:C025205 290648(Tax:10116) Chemical Gene inhibited|nmod|START_ENTITY inhibited|conj|inhibited inhibited|nmod|antibody antibody|nmod|END_ENTITY The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I . 15305021 5 1,10-phenanthroline 992,1011 PAP-II 966,972 1,10-phenanthroline PAP-II MESH:C025205 366894(Tax:10116) Chemical Gene START_ENTITY|amod|END_ENTITY The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I . 6208907 1 1,10-phenanthroline 137,156 PC-3 235,239 1,10-phenanthroline PC-3 MESH:C025205 57332 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|lines lines|conj|END_ENTITY The metal chelator 1,10-phenanthroline reversibly inhibits proliferation of two human prostate_carcinoma cell lines , PC-3 and DU145 . 18950242 1 1,10-phenanthroline 132,151 PdI2 153,157 1,10-phenanthroline PdI2 MESH:C025205 11240 Chemical Gene Cu2O|conj|START_ENTITY Cu2O|conj|END_ENTITY A new catalyst system , generated in situ from Cu2O , 1,10-phenanthroline , PdI2 , and Tol-BINAP , for the first time allows the decarboxylative coupling of carboxylic_acids with aryl_triflates . 15271515 1 1,10-phenanthroline 177,196 pen 340,343 1,10-phenanthroline pen MESH:C025205 27344 Chemical Gene phen|amod|START_ENTITY diimine|dep|phen diimine|conj|ligands ligands|dep|acyclovir acyclovir|dep|acy acy|conj|END_ENTITY Platinum compounds containing an aromatic diimine -LRB- 1,10-phenanthroline or 2,9-dimethyl-1 ,10 - phenanthroline ; phen and Me -LRB- 2 -RRB- phen , respectively -RRB- and antiviral guanosine-type ligands -LRB- acyclovir or penciclovir ; acy and pen , respectively -RRB- have been synthesised . 15018508 1 1,10-phenanthroline 189,208 PF6 251,254 1,10-phenanthroline PF6 MESH:C025205 200162 Chemical Gene attached|nmod|START_ENTITY pyridines|acl|attached consists|nmod|pyridines consists|dobj|2 2|appos|END_ENTITY The reaction between ligand 1 , which consists of two terminal pyridines attached to a central 1,10-phenanthroline -LRB- phen -RRB- , and the complex Ru -LRB- phen -RRB- 2 -LRB- CH3CN -RRB- 2 -LRB- PF6 -RRB- 2 has been studied . 8129736 0 1,10-phenanthroline 18,37 phospholipase_D 154,169 1,10-phenanthroline phospholipase D MESH:C025205 2822 Chemical Gene enhances|nsubj|START_ENTITY enhances|dobj|effects effects|nmod|fibroblasts fibroblasts|compound|activators activators|conj|staurosporine staurosporine|nmod|activity activity|amod|END_ENTITY The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine , but not sphingosine and H2O2 , on phospholipase_D activity in NIH 3T3 fibroblasts . 11516173 4 1,10-phenanthroline 572,591 P-LAP 550,555 1,10-phenanthroline P-LAP MESH:C025205 4012 Chemical Gene EDTA|conj|START_ENTITY inhibited|nsubj|EDTA affect|advcl|inhibited affect|dobj|secretion secretion|nmod|END_ENTITY Inhibitors of serine or aspartic proteases did not affect the secretion of P-LAP , while EDTA and 1,10-phenanthroline inhibited it . 28520424 1 1,10-phenanthroline 211,230 PPh2 184,188 1,10-phenanthroline PPh2 MESH:C025205 89873 Chemical Gene phen|ccomp|START_ENTITY -RSB-|dep|phen Herein|nsubj|-RSB- Herein|dep|present present|nmod|reaction reaction|nmod|_ _|appos|END_ENTITY Herein we present a theoretical study on the reaction of -LSB- Re -LRB- PPh2 -RRB- _ -LRB- CO -RRB- 3 -LRB- phen -RRB- -RSB- -LRB- phen = 1,10-phenanthroline -RRB- and -LSB- Re -LRB- PPh2 -RRB- _ -LRB- CO -RRB- 3 -LRB- bipy -RRB- -RSB- -LRB- bipy = 2,2 ' - bipyridine -RRB- toward methyl_propiolate . 18510330 2 1,10-phenanthroline 487,506 PPh_3 508,513 1,10-phenanthroline PPh 3 MESH:C025205 857 Chemical Gene START_ENTITY|appos|END_ENTITY The method involves highly selective intramolecular coupling of lactam and dihaloalkene using 2,2 ' - bipyridine as a ligand , followed by intermolecular C-S formation in the presence of another ligand -LRB- 1,10-phenanthroline , PPh_3 -RRB- and mercaptan . 11304151 1 1,10-phenanthroline 201,220 PPh4 133,137 1,10-phenanthroline PPh4 MESH:C025205 3777 Chemical Gene -RSB-|dep|START_ENTITY -RSB-|nsubj|structures structures|conj|properties properties|nmod|Fe Fe|compound|END_ENTITY Crystal structures and magnetic properties of PPh4 -LSB- Fe -LRB- Phen -RRB- -LRB- CN -RRB- 4 -RSB- * 2H2O and -LSB- -LSB- Fe -LRB- Phen -RRB- -LRB- CN -RRB- 4 -RSB- 2M -LRB- H2O -RRB- 2 -RSB- * 4H2O -LSB- Phen = 1,10-phenanthroline ; M = Mn -LRB- II -RRB- and Zn -LRB- II -RRB- -RSB- . 10441503 3 1,10-phenanthroline 557,576 PPMT 600,604 1,10-phenanthroline PPMT MESH:C025205 170818(Tax:10116) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|amod|END_ENTITY Unlike EDTA and EGTA , the metal chelator 1,10-phenanthroline strongly inhibited the PPMT activity of kidney intracellular membranes in a dose - and time-dependent manner . 10441503 8 1,10-phenanthroline 1434,1453 PPMT 1495,1499 1,10-phenanthroline PPMT MESH:C025205 170818(Tax:10116) Chemical Gene membranes|nmod|START_ENTITY Treatment|nmod|membranes increased|nsubj|Treatment increased|dobj|degradation degradation|nmod|END_ENTITY Treatment of kidney intracellular membranes with 1,10-phenanthroline increased the proteolytic degradation of PPMT by exogenous trypsin , compared to untreated membranes . 14663496 7 1,10-phenanthroline 879,898 proteinase 851,861 1,10-phenanthroline proteinase MESH:C025205 100862683 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY The proteinase was inhibited by 1,10-phenanthroline and EDTA , showing that it belonged to the metalloproteinase class . 15545371 7 1,10-phenanthroline 696,715 proteinase 745,755 1,10-phenanthroline proteinase MESH:C025205 100862683 Chemical Gene EDTA|dep|START_ENTITY compounds|dep|EDTA inactivated|nmod|compounds inactivated|conj|affected affected|nmod|inhibitors inhibitors|amod|END_ENTITY The enzyme was inactivated by metal-chelating compounds -LRB- EDTA , 1,10-phenanthroline -RRB- and less affected by serine proteinase inhibitors -LRB- diisopropylfluorophosphate , phenylmethylsulfonyl_fluoride -RRB- . 3680518 7 1,10-phenanthroline 1003,1022 proteinase 1107,1117 1,10-phenanthroline proteinase MESH:C025205 100862683 Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|xcomp|indicating indicating|ccomp|metalloproteinase metalloproteinase|nsubj|END_ENTITY The proteolytic activity in the gelatin-Sepharose-purified material was inhibited by EDTA and 1,10-phenanthroline , but not by N-ethylmaleimide or phenylmethanesulfonyl_fluoride , indicating that the proteinase was a metalloproteinase . 19134000 4 1,10-phenanthroline 632,651 PTEN 595,599 1,10-phenanthroline PTEN MESH:C025205 5728 Chemical Gene inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY EXPERIMENTAL APPROACH : We evaluated the ability of a PTEN inhibitor , potassium_bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate -LSB- bpV -LRB- phen -RRB- -RSB- , to prevent acute_lung_injury induced by oleic_acid -LRB- OA -RRB- in adult C57BL/6 mice . 22918949 4 1,10-phenanthroline 922,941 PTEN 898,902 1,10-phenanthroline PTEN MESH:C025205 399142(Tax:8355) Chemical Gene bisperoxo|dep|START_ENTITY bisperoxo|compound|END_ENTITY In Xenopus nerve-muscle cocultures , axonal growth speed was halved after contact with muscle , when compared with before contact , but when cultures were exposed to the PTEN blocker bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate , axons touching muscle grew ~ 50 % faster than their counterparts in control cultures . 2550050 7 1,10-phenanthroline 1188,1207 pump-1 1159,1165 1,10-phenanthroline pump-1 MESH:C025205 4316 Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubjpass|END_ENTITY Active pump-1 is inhibited by EDTA , 1,10-phenanthroline , and the tissue inhibitor of metalloproteinases . 3415670 0 1,10-phenanthroline 54,73 pyruvate_carboxylase 30,50 1,10-phenanthroline pyruvate carboxylase MESH:C025205 374263(Tax:9031) Chemical Gene END_ENTITY|advcl|START_ENTITY Inactivation of chicken liver pyruvate_carboxylase by 1,10-phenanthroline . 3415670 1 1,10-phenanthroline 149,168 pyruvate_carboxylase 105,125 1,10-phenanthroline pyruvate carboxylase MESH:C025205 374263(Tax:9031) Chemical Gene END_ENTITY|nmod|START_ENTITY Inactivation of chicken liver pyruvate_carboxylase by the chelating agent 1,10-phenanthroline follows pseudo-first-order kinetics . 3415670 3 1,10-phenanthroline 479,498 pyruvate_carboxylase 502,522 1,10-phenanthroline pyruvate carboxylase MESH:C025205 374263(Tax:9031) Chemical Gene END_ENTITY|amod|START_ENTITY Binding of 1,10-phenanthroline to pyruvate_carboxylase results in complete loss of ATP/Pi exchange activity , but only a 61 % decrease in pyruvate/oxaloacetate exchange activity . 10441503 7 1,10-phenanthroline 1352,1371 RhoA 1283,1287 1,10-phenanthroline RhoA MESH:C025205 117273(Tax:10116) Chemical Gene present|nsubj|START_ENTITY inhibited|advcl|present inhibited|nsubj|methylation methylation|nmod|Ras Ras|conj|END_ENTITY In addition , the methylation of immunoprecipitated Ras and RhoA from kidney intracellular membranes was strongly inhibited when 1,10-phenanthroline was present . 15169913 2 1,10-phenanthroline 407,426 rpb1-1 448,454 1,10-phenanthroline rpb1-1 MESH:C025205 854157(Tax:4932) Chemical Gene thiolutin|conj|START_ENTITY effects|nmod|thiolutin similar|nsubj|effects similar|advcl|END_ENTITY Among the five inhibitors tested , the effects of thiolutin and 1,10-phenanthroline were most similar to rpb1-1 . 9541592 12 1,10-phenanthroline 1875,1894 rTRAIL 1724,1730 1,10-phenanthroline rTRAIL MESH:C025205 246775(Tax:10116) Chemical Gene leupeptin|conj|START_ENTITY blocked|nmod|leupeptin dependent|advcl|blocked dependent|nsubj|generation generation|nmod|END_ENTITY An in vitro cleavage assay showed that generation of soluble rTRAIL was dependent on the functional activity of cysteine proteases , as it was blocked by leupeptin and E64 but not by the metalloprotease inhibitor 1,10-phenanthroline . 1842102 1 1,10-phenanthroline 261,280 Ru2 222,225 1,10-phenanthroline Ru2 MESH:C025205 51473 Chemical Gene molecules|amod|START_ENTITY consisting|nmod|molecules synthesized|advcl|consisting synthesized|dobj|complexes complexes|nmod|compound compound|acl:relcl|coordinated coordinated|nsubjpass|+ +|conj|+ +|compound|END_ENTITY We have synthesized two metal complexes of the macrocyclic compound -LRB- III , IV -RRB- , with which either Cu2 + or Ru2 + is coordinated , consisting of two 1,10-phenanthroline molecules bridged by sulfur . 1169300 2 1,10-phenanthroline 209,228 S203-2 127,133 1,10-phenanthroline S203-2 MESH:C025205 1078351(Tax:198215) Chemical Gene -RSB-|amod|START_ENTITY tetrahydroxyfluoran_methyl_ester|conj|-RSB- tetrahydroxyfluoran_methyl_ester|dep|determination determination|nmod|-RSB- -RSB-|appos|I I|dep|END_ENTITY Spectrophotometric determination of Ag -LSB- i -RSB- , CN - , I - and S203-2 - with 3,4,5,6-tetrachloro _ 3 ' ,4 ' ,5 ' ,6 ' = tetrahydroxyfluoran_methyl_ester and 1,10-phenanthroline -LRB- author 's transl -RRB- -RSB- . 21355074 6 1,10-phenanthroline 1029,1048 S2P 1176,1179 1,10-phenanthroline S2P MESH:C025205 270669(Tax:10090) Chemical Gene reproduces|nsubj|START_ENTITY reproduces|ccomp|observed observed|nmod|cells cells|acl:relcl|implicates implicates|dobj|END_ENTITY In contrast , 1,10-phenanthroline , an S2P-specific inhibitor , reproduces the molecular and biological phenotypes observed in NFV-treated cells , which implicates S2P as a target of NFV . 22540830 8 1,10-phenanthroline 1347,1366 S2P 1371,1374 1,10-phenanthroline S2P MESH:C025205 51360 Chemical Gene START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY In contrast , 1,10-phenanthroline , an S2P inhibitor , reproduced the nelfinavir-treated molecular and biological phenotype . 25880275 4 1,10-phenanthroline 720,739 S2P 693,696 1,10-phenanthroline S2P MESH:C025205 51360 Chemical Gene activity|nmod|START_ENTITY activity|nummod|END_ENTITY Nelfinavir and its analogs are more potent inhibitors of S2P cleavage activity than 1,10-phenanthroline , a metalloprotease-specific inhibitor . 17467053 7 1,10-phenanthroline 1127,1146 SDF-1 1041,1046 1,10-phenanthroline SDF-1 MESH:C025205 6387 Chemical Gene pretreatment|amod|START_ENTITY decreased|nmod|pretreatment decreased|advcl|induced induced|nsubj|spontaneous spontaneous|conj|END_ENTITY While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment . 12007650 5 1,10-phenanthroline 907,926 serine_protease 743,758 1,10-phenanthroline serine protease MESH:C025205 547512(Tax:3847) Chemical Gene mM|nmod|START_ENTITY blocked|nmod|mM inhibited|parataxis|blocked inhibited|nmod|inhibitors inhibitors|amod|END_ENTITY Protease A activity was inhibited by serine_protease inhibitors , such as phenylmethylsulfonyl_fluoride and soybean trypsin inhibitor ; moreover , the activity could be blocked by treatment with 20 mM of 1,10-phenanthroline , but could not be restored by adding metal ions . 1913672 4 1,10-phenanthroline 571,590 serine_protease 625,640 1,10-phenanthroline serine protease MESH:C025205 2147 Chemical Gene EDTA|conj|START_ENTITY affected|nmod|EDTA affected|xcomp|indicating indicating|ccomp|END_ENTITY This activity has maximal activity at pH 8 and was inhibited by diisopropylfluorophosphate but was not affected by EDTA or 1,10-phenanthroline , indicating that this enzyme is a serine_protease . 7507963 4 1,10-phenanthroline 395,414 serine_protease 429,444 1,10-phenanthroline serine protease MESH:C025205 2147 Chemical Gene START_ENTITY|nmod|END_ENTITY Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes . 9763222 6 1,10-phenanthroline 1142,1161 serine_protease 1196,1211 1,10-phenanthroline serine protease MESH:C025205 2147 Chemical Gene START_ENTITY|acl|indicating indicating|dobj|nature nature|amod|END_ENTITY Moreover , this enzyme was inhibited mostly by the serine-protease inhibitors leupeptin and di-isopropyl_fluorophosphate and not by the cysteine protease inhibitor E-64 or the metalloprotease inhibitor 1,10-phenanthroline -LRB- Component_H , CH -RRB- , indicating the serine_protease nature of this enzyme . 9763222 6 1,10-phenanthroline 1142,1161 serine-protease 991,1006 1,10-phenanthroline serine-protease MESH:C025205 2147 Chemical Gene E-64|conj|START_ENTITY leupeptin|conj|E-64 leupeptin|amod|END_ENTITY Moreover , this enzyme was inhibited mostly by the serine-protease inhibitors leupeptin and di-isopropyl_fluorophosphate and not by the cysteine protease inhibitor E-64 or the metalloprotease inhibitor 1,10-phenanthroline -LRB- Component_H , CH -RRB- , indicating the serine_protease nature of this enzyme . 20094679 0 1,10-phenanthroline 48,67 SERS 0,4 1,10-phenanthroline SERS MESH:C025205 54938 Chemical Gene adsorption|nmod|START_ENTITY investigation|nmod|adsorption investigation|nsubj|END_ENTITY SERS and DFT investigation on the adsorption of 1,10-phenanthroline on transition_metal surfaces . 20094679 1 1,10-phenanthroline 114,133 SERS 98,102 1,10-phenanthroline SERS MESH:C025205 54938 Chemical Gene phen|amod|START_ENTITY spectra|nmod|phen spectra|compound|END_ENTITY SERS spectra of 1,10-phenanthroline -LRB- phen -RRB- on iron smooth surface doped with silver nanoparticles have been recorded and compared with those previously obtained on Ag doped smooth silver , copper and nickel surfaces . 19837674 2 1,10-phenanthroline 447,466 SERT 327,331 1,10-phenanthroline SERT MESH:C025205 6532 Chemical Gene copper|dep|START_ENTITY using|dobj|copper cross-linked|xcomp|using cross-linked|nsubjpass|residues residues|nmod|positions positions|nmod|transmembranes transmembranes|nmod|END_ENTITY We show here that cysteine residues at positions in transmembranes 1 and 3 of SERT , like the corresponding positions in the gamma-aminobutyric_acid transporter , can be cross-linked using copper -LRB- II -RRB- -LRB- 1,10-phenanthroline -RRB- -LRB- 3 -RRB- . 24442907 0 1,10-phenanthroline 99,118 serum_albumin 139,152 1,10-phenanthroline serum albumin MESH:C025205 213 Chemical Gene L-histidine|conj|START_ENTITY ligands|amod|L-histidine containing|dobj|ligands containing|nmod|END_ENTITY Multispectroscopic studies on the interaction of a platinum -LRB- II -RRB- complex containing L-histidine and 1,10-phenanthroline ligands with bovine serum_albumin . 25513861 1 1,10-phenanthroline 253,272 Serum_Albumin 290,303 1,10-phenanthroline Serum Albumin MESH:C025205 213 Chemical Gene =|ccomp|START_ENTITY -RSB-|parataxis|= -RSB-|advcl|investigated investigated|nsubjpass|HSA HSA|appos|END_ENTITY The interaction between -LSB- Pd -LRB- But-dtc -RRB- -LRB- phen -RRB- -RSB- NO3 -LRB- where But-dtc = butyldithiocarbamate and phen = 1,10-phenanthroline -RRB- with HSA -LRB- Human Serum_Albumin -RRB- was investigated by applying fluorescence , UV-Vis and circular dichroism techniques under physiological conditions . 2157617 6 1,10-phenanthroline 970,989 SP1_and_transformed_glucocorticoid_receptor 1049,1092 1,10-phenanthroline SP1 and transformed glucocorticoid receptor MESH:C025205 6667 Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|DNA DNA|nmod|END_ENTITY Here , we report that although 1,10-phenanthroline , a metal ion chelating agent , inhibited the DNA binding of SP1_and_transformed_glucocorticoid_receptor , no inhibition of transformed AhR was observed . 1938939 4 1,10-phenanthroline 599,618 SSA4 799,803 1,10-phenanthroline SSA4 MESH:C025205 856840(Tax:4932) Chemical Gene intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|HSC82 HSC82|dep|END_ENTITY Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- . 28208699 4 1,10-phenanthroline 828,847 syndecan-4 755,765 1,10-phenanthroline syndecan-4 MESH:C025205 508133(Tax:9913) Chemical Gene identified|dobj|START_ENTITY investigated|conj|identified investigated|advcl|determine determine|xcomp|capable capable|advcl|analyzing analyzing|dobj|expression expression|nmod|END_ENTITY Here , we investigated organic-inorganic hybrid molecules to determine a variant capable of analyzing the expression of syndecan-4 , a transmembrane heparan-sulfate proteoglycan , and identified 1,10-phenanthroline -LRB- o-Phen -RRB- with or without zinc -LRB- Zn-Phen -RRB- or rhodium -LRB- Rh-Phen -RRB- . 26505793 0 1,10-phenanthroline 33,52 T2R5 69,73 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene START_ENTITY|nmod|transduction transduction|compound|END_ENTITY GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell . 26505793 4 1,10-phenanthroline 760,779 T2R5 838,842 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene START_ENTITY|acl:relcl|known known|dobj|agonist agonist|nmod|taste_receptor_type_2_member_5 taste_receptor_type_2_member_5|appos|END_ENTITY We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- . 26505793 5 1,10-phenanthroline 1043,1062 T2R5 1119,1123 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene ligand|conj|START_ENTITY able|csubj|ligand able|xcomp|secrete secrete|nmod|stimulation stimulation|nmod|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 5 1,10-phenanthroline 1043,1062 T2R5 991,995 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene ligand|conj|START_ENTITY ligand|conj|evaluated evaluated|dobj|existence existence|nmod|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 5 1,10-phenanthroline 911,930 T2R5 1119,1123 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene used|dobj|START_ENTITY used|advcl|able able|xcomp|secrete secrete|nmod|stimulation stimulation|nmod|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 5 1,10-phenanthroline 911,930 T2R5 991,995 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene used|dobj|START_ENTITY used|advcl|able able|csubj|ligand ligand|conj|evaluated evaluated|dobj|existence existence|nmod|END_ENTITY To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells . 26505793 6 1,10-phenanthroline 1282,1301 T2R5 1219,1223 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene secreted|nmod|START_ENTITY colocalized|conj|secreted colocalized|nmod|END_ENTITY Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells . 26505793 6 1,10-phenanthroline 1282,1301 T2R5 1306,1310 1,10-phenanthroline T2R5 MESH:C025205 54429 Chemical Gene START_ENTITY|nmod|transduction transduction|compound|END_ENTITY Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells . 10727411 5 1,10-phenanthroline 979,998 TACE 805,809 1,10-phenanthroline TACE MESH:C025205 11491(Tax:10090) Chemical Gene detected|conj|START_ENTITY detected|nsubj|form form|nmod|END_ENTITY An additional form of TACE , lacking the pro and cytoplasmic domains , is detected when cell lysates are prepared in the presence of EDTA instead of a hydroxamate-based metalloprotease inhibitor or 1,10-phenanthroline . 26505793 4 1,10-phenanthroline 760,779 taste_receptor_type_2_member_5 806,836 1,10-phenanthroline taste receptor type 2 member 5 MESH:C025205 54429 Chemical Gene START_ENTITY|acl:relcl|known known|dobj|agonist agonist|nmod|END_ENTITY We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- . 1431887 1 1,10-phenanthroline 204,223 TFIIIA 147,153 1,10-phenanthroline TFIIIA MESH:C025205 397777(Tax:8355) Chemical Gene treated|advcl|START_ENTITY isolated|conj|treated isolated|nsubjpass|Transcription_factor_IIIA Transcription_factor_IIIA|appos|END_ENTITY Transcription_factor_IIIA -LRB- TFIIIA -RRB- was isolated from Xenopus ovary and treated with 1,10-phenanthroline to remove zinc . 9057093 10 1,10-phenanthroline 2054,2073 TGF_alpha 1982,1991 1,10-phenanthroline TGF alpha MESH:C025205 7039 Chemical Gene EDTA|conj|START_ENTITY inhibited|nmod|EDTA metalloenzyme|advcl|inhibited metalloenzyme|nsubj|ase ase|compound|END_ENTITY Inhibition studies indicate that the plasma membrane `` TGF_alpha ase is a metalloenzyme as it was inhibited by EDTA , EGTA , and 1,10-phenanthroline but not by elastase or serine protease inhibitors . 9057093 11 1,10-phenanthroline 2195,2214 TGF_alpha 2126,2135 1,10-phenanthroline TGF alpha MESH:C025205 7039 Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|compound|END_ENTITY `` TGF_alpha ase '' activity on intact cells was shown to be inhibited by 1,10-phenanthroline , which further supports this suggestion . 1406451 7 1,10-phenanthroline 1337,1356 TIMP 1417,1421 1,10-phenanthroline TIMP MESH:C025205 7076 Chemical Gene tissue_inhibitor_of_metalloproteinase|amod|START_ENTITY tissue_inhibitor_of_metalloproteinase|appos|END_ENTITY Similar to APMA-activated human prostromelysin-1 , the APMA-activated canine metalloproteinase was inhibited by 1,10-phenanthroline or recombinant human tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- . 8086430 4 1,10-phenanthroline 852,871 TIMP 934,938 1,10-phenanthroline TIMP MESH:C025205 7076 Chemical Gene EDTA|conj|START_ENTITY prevented|nmod|EDTA prevented|parataxis|compete compete|nsubj|END_ENTITY Complex formation with the whole molecule is prevented by EDTA and by 1,10-phenanthroline demonstrating the importance of the active site ; additionally TIMP and TIMP-2 will compete with a reversibly bound peptide hydroxamic_acid inhibitor for the active site . 8238531 5 1,10-phenanthroline 1035,1054 TIMP 1026,1030 1,10-phenanthroline TIMP MESH:C025205 317694(Tax:9913) Chemical Gene prevented|conj|START_ENTITY prevented|nmod|inclusion inclusion|nmod|tissue_inhibitor_of_metalloproteinase tissue_inhibitor_of_metalloproteinase|appos|END_ENTITY Incubation of BPMVE cells with the 96-kDa gelatinase increased monolayer permeability , an effect prevented by inclusion of either tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- or 1,10-phenanthroline . 8499486 8 1,10-phenanthroline 1209,1228 TIMP 1233,1237 1,10-phenanthroline TIMP MESH:C025205 7076 Chemical Gene EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY Several criteria indicate that this enzyme is a member of the family of matrix metalloproteinases : -LRB- 1 -RRB- this activity was inhibited by EDTA , 1,10-phenanthroline and TIMP ; -LRB- 2 -RRB- this activity bound to a gelatin-agarose affinity resin ; -LRB- 3 -RRB- it has a mass of approx . 10212153 8 1,10-phenanthroline 1384,1403 TIMP-1 1374,1380 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene END_ENTITY|conj|START_ENTITY The addition of MMP inhibitors human recombinant TIMP-1 or 1,10-phenanthroline to cultures under basal conditions induced matrix deposition in a dose-dependent manner , which was not observed with the serine protease inhibitor epsilon-amino-n-caproic_acid -LRB- ACA -RRB- . 11162584 7 1,10-phenanthroline 927,946 TIMP-1 1072,1078 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene START_ENTITY|conj|inhibitors inhibitors|nmod|metalloproteinases metalloproteinases|amod|END_ENTITY Its proteolytic activity was blocked by 1,10-phenanthroline , EDTA , EGTA , and a synthetic matrix metalloproteinase -LRB- MMP -RRB- inhibitor and not by the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 . 14511382 4 1,10-phenanthroline 904,923 TIMP-1 928,934 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene START_ENTITY|conj|END_ENTITY The calcium-induced activation and truncation of the MMP-9 / CSPG complex was independent of the concentration of the complex , inhibited by the MMP inhibitors EDTA , 1,10-phenanthroline and TIMP-1 , but not by general inhibitors of serine , thiol and acid proteinases . 7615167 11 1,10-phenanthroline 1565,1584 TIMP-1 1539,1545 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene END_ENTITY|conj|START_ENTITY Either TIMP-1 or the Zn chelator 1,10-phenanthroline reduced the zymographic activity in cryosections of atheroma from humans or rabbits . 7989608 10 1,10-phenanthroline 1661,1680 TIMP-1 1705,1711 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene inhibitors|conj|START_ENTITY MMP|amod|inhibitors MMP|conj|END_ENTITY The MMP inhibitors , EDTA and 1,10-phenanthroline , as well as recombinant TIMP-1 , reduced these activities which colocalized with regions of increased immunoreactive MMP expression , i.e. , the shoulders , core , and microvasculature of the plaques . 8910479 7 1,10-phenanthroline 1259,1278 TIMP-1 1251,1257 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene END_ENTITY|conj|START_ENTITY All activities were inhibited by TIMP-1 , 1,10-phenanthroline , and EDTA . 9548562 11 1,10-phenanthroline 1906,1925 TIMP-1 1971,1977 1,10-phenanthroline TIMP-1 MESH:C025205 7076 Chemical Gene inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY Ionomycin - and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- . 11162584 7 1,10-phenanthroline 927,946 TIMP-2 1083,1089 1,10-phenanthroline TIMP-2 MESH:C025205 7077 Chemical Gene START_ENTITY|conj|inhibitors inhibitors|nmod|metalloproteinases metalloproteinases|amod|TIMP-1 TIMP-1|conj|END_ENTITY Its proteolytic activity was blocked by 1,10-phenanthroline , EDTA , EGTA , and a synthetic matrix metalloproteinase -LRB- MMP -RRB- inhibitor and not by the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 . 15095267 7 1,10-phenanthroline 1802,1821 TIMP-2 1678,1684 1,10-phenanthroline TIMP-2 MESH:C025205 7077 Chemical Gene inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|MMP-2 MMP-2|conj|END_ENTITY Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline . 1648398 4 1,10-phenanthroline 935,954 TIMP-2 1008,1014 1,10-phenanthroline TIMP-2 MESH:C025205 374178(Tax:9031) Chemical Gene EDTA|conj|START_ENTITY chelators|nmod|EDTA chelators|conj|inhibitors inhibitors|ref|that END_ENTITY|mark|that The enzyme was inhibited by metal chelators such as EDTA and 1,10-phenanthroline , but not by inhibitors is suggested that this may be TIMP-2 . 8086430 4 1,10-phenanthroline 852,871 TIMP-2 943,949 1,10-phenanthroline TIMP-2 MESH:C025205 7077 Chemical Gene EDTA|conj|START_ENTITY prevented|nmod|EDTA prevented|parataxis|compete compete|nsubj|TIMP TIMP|conj|END_ENTITY Complex formation with the whole molecule is prevented by EDTA and by 1,10-phenanthroline demonstrating the importance of the active site ; additionally TIMP and TIMP-2 will compete with a reversibly bound peptide hydroxamic_acid inhibitor for the active site . 15013428 4 1,10-phenanthroline 779,798 TIMP-3 852,858 1,10-phenanthroline TIMP-3 MESH:C025205 7078 Chemical Gene EDTA|conj|START_ENTITY EDTA|conj|tissue_inhibitor_of_metalloproteinases-3 tissue_inhibitor_of_metalloproteinases-3|dep|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 15013428 4 1,10-phenanthroline 779,798 TIMP-4 865,871 1,10-phenanthroline TIMP-4 MESH:C025205 7079 Chemical Gene EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 1406451 7 1,10-phenanthroline 1337,1356 tissue_inhibitor_of_metalloproteinase 1378,1415 1,10-phenanthroline tissue inhibitor of metalloproteinase MESH:C025205 7076 Chemical Gene END_ENTITY|amod|START_ENTITY Similar to APMA-activated human prostromelysin-1 , the APMA-activated canine metalloproteinase was inhibited by 1,10-phenanthroline or recombinant human tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- . 8238531 5 1,10-phenanthroline 1035,1054 tissue_inhibitor_of_metalloproteinase 987,1024 1,10-phenanthroline tissue inhibitor of metalloproteinase MESH:C025205 317694(Tax:9913) Chemical Gene prevented|conj|START_ENTITY prevented|nmod|inclusion inclusion|nmod|END_ENTITY Incubation of BPMVE cells with the 96-kDa gelatinase increased monolayer permeability , an effect prevented by inclusion of either tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- or 1,10-phenanthroline . 9548562 11 1,10-phenanthroline 1906,1925 tissue_inhibitor_of_metalloproteinase-1 1930,1969 1,10-phenanthroline tissue inhibitor of metalloproteinase-1 MESH:C025205 7076 Chemical Gene START_ENTITY|conj|END_ENTITY Ionomycin - and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- . 10551873 8 1,10-phenanthroline 1339,1358 tissue_inhibitor_of_metalloproteinases-2 1448,1488 1,10-phenanthroline tissue inhibitor of metalloproteinases-2 MESH:C025205 7077 Chemical Gene blocked|dep|START_ENTITY blocked|nsubj|reference reference|acl|hydroxamic_acid hydroxamic_acid|dobj|inhibitors inhibitors|conj|potently potently|amod|END_ENTITY EDTA , 1,10-phenanthroline , reference hydroxamic_acid MMP inhibitors , tissue inhibitor of metalloproteinases-1 , and tissue_inhibitor_of_metalloproteinases-2 all potently blocked MT4-MMPCD enzymatic activity . 15013428 4 1,10-phenanthroline 779,798 tissue_inhibitor_of_metalloproteinases-3 810,850 1,10-phenanthroline tissue inhibitor of metalloproteinases-3 MESH:C025205 7078 Chemical Gene EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 . 10925303 8 1,10-phenanthroline 1102,1121 TNF 1236,1239 1,10-phenanthroline TNF MESH:C025205 7124 Chemical Gene inhibited|advcl|START_ENTITY inhibited|conj|considered considered|advcl|inhibited inhibited|dobj|activation activation|compound|END_ENTITY Shedding was also inhibited by 1,10-phenanthroline , but this effect was considered nonspecific as the compound , at variance with KB8301 , almost completely inhibited TNF and FMLP-induced PMN activation . 10614779 4 1,10-phenanthroline 808,827 TNF-alpha 691,700 1,10-phenanthroline TNF-alpha MESH:C025205 7124 Chemical Gene also|dep|START_ENTITY inhibitors|conj|also inhibited|nmod|inhibitors inhibited|advcl|inhibited inhibited|dobj|processing processing|nmod|END_ENTITY Although only hydroxamate matrix metalloproteinase -LRB- MMP -RRB- inhibitors inhibited the basal processing and release of TNF-alpha , the PMA-induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin -LRB- 3,4-DCI -RRB- , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine_chloromethyl_ketone -LRB- TPCK -RRB- . 10614779 5 1,10-phenanthroline 973,992 TNF-alpha 1021,1030 1,10-phenanthroline TNF-alpha MESH:C025205 7124 Chemical Gene inhibitors|conj|START_ENTITY MMP|amod|inhibitors inhibited|nsubj|MMP inhibited|dobj|processing processing|nmod|END_ENTITY Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface , whereas 3,4-DCI , iodoacetamide , and TPCK inhibited the transport of TNF-alpha to the cell surface . 10614779 5 1,10-phenanthroline 973,992 TNF-alpha 1120,1129 1,10-phenanthroline TNF-alpha MESH:C025205 7124 Chemical Gene inhibitors|conj|START_ENTITY MMP|amod|inhibitors inhibited|nsubj|MMP inhibited|advcl|inhibited inhibited|dobj|transport transport|nmod|END_ENTITY Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface , whereas 3,4-DCI , iodoacetamide , and TPCK inhibited the transport of TNF-alpha to the cell surface . 11867336 6 1,10-phenanthroline 1456,1475 TNF-alpha 1316,1325 1,10-phenanthroline TNF-alpha MESH:C025205 24835(Tax:10116) Chemical Gene inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance showed|nsubj|incubation incubation|nmod|medium medium|conj|END_ENTITY IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline . 9688944 8 1,10-phenanthroline 1575,1594 TNF-alpha 1426,1435 1,10-phenanthroline TNF-alpha MESH:C025205 7124 Chemical Gene EDTA|conj|START_ENTITY aprotinin|conj|EDTA blocked|nmod|aprotinin medium|acl:relcl|blocked increased|nmod|medium increased|nsubj|END_ENTITY Fn-substrate zymography revealed that TNF-alpha increased the expression of two proteinases within the conditioned medium in which activity could be blocked by aprotinin but not by EDTA , 1,10-phenanthroline , leupeptin , or pepstatin . 10754213 7 1,10-phenanthroline 916,935 TN-R 984,988 1,10-phenanthroline TN-R MESH:C025205 21960(Tax:10090) Chemical Gene inhibited|nsubj|START_ENTITY inhibited|dobj|release release|compound|END_ENTITY In addition , 1,10-phenanthroline -LRB- a metalloprotease blocker -RRB- partially inhibited TN-R release in the presence of calcium ions . 21149586 7 1,10-phenanthroline 1462,1481 Tp0751 1392,1398 1,10-phenanthroline Tp0751 MESH:C025205 2611130(Tax:243276) Chemical Gene presence|nmod|START_ENTITY abolished|nmod|presence abolished|nsubjpass|activity activity|nmod|END_ENTITY The proteolytic activity of Tp0751 was abolished by the presence of the metalloprotease inhibitor 1,10-phenanthroline . 1431887 1 1,10-phenanthroline 204,223 Transcription_factor_IIIA 120,145 1,10-phenanthroline Transcription factor IIIA MESH:C025205 397777(Tax:8355) Chemical Gene treated|advcl|START_ENTITY isolated|conj|treated isolated|nsubjpass|END_ENTITY Transcription_factor_IIIA -LRB- TFIIIA -RRB- was isolated from Xenopus ovary and treated with 1,10-phenanthroline to remove zinc . 6885162 1 1,10-phenanthroline 195,214 transferrin 155,166 1,10-phenanthroline transferrin MESH:C025205 7018 Chemical Gene serum|conj|START_ENTITY serum|appos|END_ENTITY Human serum , human transferrin -LRB- TF -RRB- , and the iron chelator 1,10-phenanthroline -LRB- OP -RRB- produce iron-reversible fungistatic activity which has been attributed to simple iron deprivation . 15305021 5 1,10-phenanthroline 992,1011 TRH 918,921 1,10-phenanthroline TRH MESH:C025205 25569(Tax:10116) Chemical Gene inhibited|nmod|START_ENTITY inhibited|nsubjpass|activities activities|nmod|END_ENTITY The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I . 19856296 5 1,10-phenanthroline 749,768 trypsin_inhibitor 681,698 1,10-phenanthroline trypsin inhibitor MESH:C025205 548021(Tax:3847) Chemical Gene but|conj|START_ENTITY phenylmethane_sulfonylfluoride|dep|but phenylmethane_sulfonylfluoride|appos|END_ENTITY Its pH optimum was in the range of 9-11 , it was remarkably heat-stable and was not inhibited by phenylmethane_sulfonylfluoride , soybean trypsin_inhibitor , aprotinin or alpha1-antitrypsin , but by EDTA and 1,10-phenanthroline suggesting properties of a metalloprotease . 16949178 6 1,10-phenanthroline 1186,1205 VEGF 1086,1090 1,10-phenanthroline VEGF MESH:C025205 7422 Chemical Gene using|xcomp|START_ENTITY using|nsubj|Neutralisation Neutralisation|nmod|END_ENTITY Neutralisation of VEGF as well as inhibition of matrix metalloproteases -LRB- MMPs -RRB- using the broad spectrum MMP inhibitor 1,10-phenanthroline , both strongly reduced the melanoma-induced tube formation . 23249709 2 1,10-phenanthroline 375,394 VEGF 295,299 1,10-phenanthroline VEGF MESH:C025205 7422 Chemical Gene -RSB-|amod|START_ENTITY inhibitors|dep|-RSB- inhibitors|amod|vitro vitro|nmod|presence presence|nmod|END_ENTITY METHODS : Human umbilical vein endothelial cells -LRB- HUVECs -RRB- were cultured in vitro in the presence or absence of VEGF , doxycycline , or broad-spectrum matrix metalloproteinase -LRB- MMP -RRB- inhibitors -LRB- 1,10-phenanthroline -LSB- 1PT -RSB- and batimastat -RRB- . 8226890 0 1,10-phenanthroline 130,149 YAP1 58,62 1,10-phenanthroline YAP1 MESH:C025205 855005(Tax:4932) Chemical Gene caused|advcl|START_ENTITY inhibition|acl|caused alleviates|dobj|inhibition alleviates|nsubj|Overexpression Overexpression|conj|END_ENTITY Overexpression of YAP2 , coding for a new yAP protein , and YAP1 in Saccharomyces_cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline . 8226890 3 1,10-phenanthroline 484,503 YAP1 582,586 1,10-phenanthroline YAP1 MESH:C025205 855005(Tax:4932) Chemical Gene concentrations|nmod|START_ENTITY caused|nmod|concentrations yeast|acl|caused arrest|nmod|yeast overcome|nsubjpass|arrest overcome|nmod|over-expression over-expression|nmod|END_ENTITY Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline , resulting in zinc and/or iron deprivation , is overcome by over-expression of YAP1 or YAP2 . 8226890 5 1,10-phenanthroline 792,811 yap2 704,708 1,10-phenanthroline yap2 MESH:C025205 852033(Tax:4932) Chemical Gene caused|advcl|START_ENTITY conditions|acl|caused thermotolerance|nmod|conditions has|dobj|thermotolerance has|nsubj|mutant mutant|amod|END_ENTITY On the other hand , a yap2 null mutant has an increased thermotolerance under starvation conditions caused by 1,10-phenanthroline . 8226890 0 1,10-phenanthroline 130,149 YAP2 18,22 1,10-phenanthroline YAP2 MESH:C025205 852033(Tax:4932) Chemical Gene caused|advcl|START_ENTITY inhibition|acl|caused alleviates|dobj|inhibition alleviates|nsubj|Overexpression Overexpression|nmod|END_ENTITY Overexpression of YAP2 , coding for a new yAP protein , and YAP1 in Saccharomyces_cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline . 8226890 3 1,10-phenanthroline 484,503 YAP2 590,594 1,10-phenanthroline YAP2 MESH:C025205 852033(Tax:4932) Chemical Gene concentrations|nmod|START_ENTITY caused|nmod|concentrations yeast|acl|caused arrest|nmod|yeast overcome|nsubjpass|arrest overcome|nmod|over-expression over-expression|nmod|YAP1 YAP1|conj|END_ENTITY Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline , resulting in zinc and/or iron deprivation , is overcome by over-expression of YAP1 or YAP2 . 21724882 11 1,10-phenanthroline 1625,1644 Zap1p 1586,1591 1,10-phenanthroline Zap1p MESH:C025205 853390(Tax:4932) Chemical Gene addition|nmod|START_ENTITY END_ENTITY|conj|addition Paradoxically , deletion of the zinc-responsive transcription factor Zap1p or addition of the zinc chelator 1,10-phenanthroline significantly increased diclofenac toxicity , establishing a regulatory role for zinc in diclofenac resistance . 22252336 2 1,10-phenanthroline 558,577 zfVg1 448,453 1,10-phenanthroline zfVg1 MESH:C025205 559475(Tax:7955) Chemical Gene found|nsubjpass|START_ENTITY identified|conj|found identified|nsubjpass|1 1|appos|END_ENTITY Two 30 - to 35-kDa polypeptides homologous to the N-terminal lipovitellin 1 -LRB- Lv1 -RRB- domain of the 150-kDa zebrafish vitellogenin 1 -LRB- zfVg1 -RRB- were identified as the damage recognition factors in zebrafish extracts , and the metal-chelating agent 1,10-phenanthroline -LRB- OP -RRB- was found to inhibit the embryonic UV-damaged-DNA binding activity . 16487686 8 1,10-phenanthroline 843,862 zinc-metallopeptidase 866,887 1,10-phenanthroline zinc-metallopeptidase MESH:C025205 79258 Chemical Gene START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY The extracellular peptidases were most active in acidic pH -LRB- 5.5 -RRB- and fully inhibited by 1,10-phenanthroline , a zinc-metallopeptidase inhibitor . 2606151 5 1.10-phenanthroline 997,1016 ACE 1051,1054 1.10-phenanthroline ACE MESH:C025205 100715217 Chemical Gene incubated|advcl|START_ENTITY ileum|acl|incubated chelator|nmod|ileum chelator|xcomp|able able|xcomp|inhibit inhibit|dobj|END_ENTITY Furthermore KPP potentiated the bradykinin contracting effects on the rat uterus , a preparation with very poor ACE activity , and on guinea-pig ileum previously incubated with 1.10-phenanthroline , a metal chelator able to inhibit ACE and kininase I activities and with phosphoramidon , a specific inhibitor of neutral endopeptidase -LRB- NEP -RRB- . 2606151 5 1.10-phenanthroline 997,1016 ACE 933,936 1.10-phenanthroline ACE MESH:C025205 24310(Tax:10116) Chemical Gene incubated|advcl|START_ENTITY ileum|acl|incubated chelator|nmod|ileum potentiated|conj|chelator potentiated|nmod|activity activity|compound|END_ENTITY Furthermore KPP potentiated the bradykinin contracting effects on the rat uterus , a preparation with very poor ACE activity , and on guinea-pig ileum previously incubated with 1.10-phenanthroline , a metal chelator able to inhibit ACE and kininase I activities and with phosphoramidon , a specific inhibitor of neutral endopeptidase -LRB- NEP -RRB- . 7759568 8 1-10_Phenanthroline 1092,1111 endooligopeptidase_A 975,995 1-10 Phenanthroline endooligopeptidase A MESH:C025205 170845(Tax:10116) Chemical Gene DTNB|conj|START_ENTITY inhibited|nmod|DTNB enhanced|conj|inhibited enhanced|nmod|END_ENTITY Similarly to rabbit brain endooligopeptidase_A , the PC12 endooligopeptidase_A-like activity was enhanced by DTT , totally inhibited by DTNB and 1-10_Phenanthroline , partially inhibited by cFP-AAF-pAb , and not affected by PMSF . 3166980 4 1,10-Phenanthroline 802,821 alcohol_dehydrogenase 870,891 1,10-Phenanthroline alcohol dehydrogenase MESH:C025205 10327 Chemical Gene competitively|amod|START_ENTITY inhibit|nsubj|competitively inhibit|dep|demonstrating demonstrating|nsubj|ethanol ethanol|amod|END_ENTITY 1,10-Phenanthroline and 4-methylpyrazole competitively inhibit both alcohol_dehydrogenase catalyzed ethanol and 3 beta-hydroxy-5_beta-steroid oxidation demonstrating that the catalysis of both types of substrates occurs at the same active site . 1793037 2 1,10-Phenanthroline 284,303 carboxypeptidase_B 307,325 1,10-Phenanthroline carboxypeptidase B MESH:C025205 24271(Tax:10116) Chemical Gene START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY 1,10-Phenanthroline , a carboxypeptidase_B inhibitor -LRB- 2 mg/kg i.p. -RRB- , in combination with captopril enhanced the algesic effect of PBQ by 309-360 % . 205625 5 1,10-Phenanthroline 587,606 cytochrome_c 630,642 1,10-Phenanthroline cytochrome c MESH:C025205 100053958(Tax:9796) Chemical Gene reduction|amod|START_ENTITY reduction|nmod|Fe2 Fe2|amod|END_ENTITY 1,10-Phenanthroline inhibited reduction of cytochrome_c b Fe2 + . 6196359 9 1,10-Phenanthroline 880,899 factor_A 925,933 1,10-Phenanthroline factor A MESH:C025205 397777(Tax:8355) Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|binding binding|nmod|END_ENTITY 1,10-Phenanthroline also inhibits binding of factor_A to the intragenic control region of the 5 S RNA gene . 20605713 0 1,10-Phenanthroline 0,19 glucose_oxidase 49,64 1,10-Phenanthroline glucose oxidase MESH:C025205 54363 Chemical Gene derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY 1,10-Phenanthroline derivatives as mediators for glucose_oxidase . 7864812 15 1,10-Phenanthroline 2188,2207 IDE 2225,2228 1,10-Phenanthroline IDE MESH:C025205 25700(Tax:10116) Chemical Gene increased|nsubj|START_ENTITY increased|dobj|labelling labelling|compound|END_ENTITY 1,10-Phenanthroline -LRB- 2 mM -RRB- increased IDE labelling , but decreased the labelling of 82 and 27 kDa bands . 8024692 0 1,10-Phenanthroline 0,19 insulin 137,144 1,10-Phenanthroline insulin MESH:C025205 3630 Chemical Gene increases|nsubj|START_ENTITY increases|conj|has has|dobj|effect effect|nmod|ability ability|nmod:poss|END_ENTITY 1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels . 8024692 0 1,10-Phenanthroline 0,19 insulin 54,61 1,10-Phenanthroline insulin MESH:C025205 3630 Chemical Gene increases|nsubj|START_ENTITY increases|dobj|accumulation accumulation|nmod|END_ENTITY 1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels . 8024692 0 1,10-Phenanthroline 0,19 insulin 88,95 1,10-Phenanthroline insulin MESH:C025205 3630 Chemical Gene increases|nsubj|START_ENTITY increases|nmod|degradation degradation|compound|END_ENTITY 1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels . 6208907 0 1,10-Phenanthroline 0,19 PC-3 101,105 1,10-Phenanthroline PC-3 MESH:C025205 57332 Chemical Gene reversibility|amod|START_ENTITY inhibits|nsubj|reversibility inhibits|dobj|proliferation proliferation|nmod|lines lines|appos|END_ENTITY 1,10-Phenanthroline reversibility inhibits proliferation of two human prostate_carcinoma cell lines -LRB- PC-3 and DU145 -RRB- . 10441503 4 1,10-Phenanthroline 686,705 PPMT 846,850 1,10-Phenanthroline PPMT MESH:C025205 170818(Tax:10116) Chemical Gene inhibit|nsubj|START_ENTITY inhibit|dobj|methylation methylation|nmod|N-acetyl-S-all-trans-geranylgeranyl-l-cysteine N-acetyl-S-all-trans-geranylgeranyl-l-cysteine|appos|substrate substrate|nmod|END_ENTITY 1,10-Phenanthroline was found to inhibit the methylation of the prenylcysteine analog N-acetyl-S-all-trans-geranylgeranyl-l-cysteine , a synthetic substrate for PPMT , with an IC -LRB- 50 -RRB- of 2.2 mM . 10364476 5 1,10-Phenanthroline 482,501 Ro52 598,602 1,10-Phenanthroline Ro52 MESH:C025205 6737 Chemical Gene found|nsubjpass|START_ENTITY found|xcomp|suggesting suggesting|ccomp|functional functional|nsubj|fingers fingers|nmod|END_ENTITY 1,10-Phenanthroline , a chelater of zinc , was found to inhibit this interaction , suggesting that the zinc fingers of Ro52 are functional . 25513861 0 1,10-Phenanthroline 108,127 Serum_Albumin 47,60 1,10-Phenanthroline Serum Albumin MESH:C025205 213 Chemical Gene Ligands|amod|START_ENTITY Containing|dobj|Ligands Complex|xcomp|Containing Complex|nsubj|Investigation Investigation|nmod|END_ENTITY Investigation of the Interaction Between Human Serum_Albumin and Antitumor Palladium -LRB- II -RRB- Complex Containing 1,10-Phenanthroline and Dithiocarbamate Ligands . 28208699 0 1,10-Phenanthroline 69,88 Syndecan-4 13,23 1,10-Phenanthroline Syndecan-4 MESH:C025205 508133(Tax:9913) Chemical Gene Structure|amod|START_ENTITY Molecules|nmod|Structure END_ENTITY|nmod|Molecules Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells . 27812033 1 1,10-phenanthroline-5-carbaldehyde 252,286 PF6 191,194 1,10-phenanthroline-5-carbaldehyde PF6 null 200162 Chemical Gene 1|dep|START_ENTITY END_ENTITY|dep|1 UNASSIGNED : A long-lived aldol reaction-based iridium -LRB- III -RRB- chemosensor -LSB- Ir -LRB- ppy -RRB- 2 -LRB- 5-CHOphen -RRB- -RSB- PF6 -LRB- 1 , where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde -RRB- for proline detection has been synthesized . 9485356 2 1,10-phenanthroline-copper 199,225 carbonic_anhydrase_II 284,305 1,10-phenanthroline-copper carbonic anhydrase II null 280740(Tax:9913) Chemical Gene investigate|nmod|START_ENTITY targeted|advcl|investigate targeted|nsubjpass|sites sites|nmod|I I|conj|END_ENTITY To investigate the mechanism of scission of proteins by the chemical cleaving agent 1,10-phenanthroline-copper , the active sites of human carbonic anydrase I and bovine carbonic_anhydrase_II have been targeted for cleavage by a tight binding sulfonamide inhibitor tethered to the metal complex . 1903535 3 1,10-phenanthroline-Cu 626,648 S1_and_T1 578,587 1,10-phenanthroline-Cu S1 and T1 MESH:C025205 5707;921 Chemical Gene used|nsubjpass|START_ENTITY and/or|acl:relcl|used nucleases|dobj|and/or nucleases|nsubj|nucleases nucleases|appos|END_ENTITY To study the P-90-RNA interaction , protein nucleases -LRB- RNase S1_and_T1 -RRB- and chemical nucleases FeEDTA and/or 1,10-phenanthroline-Cu were used as probes of an oligonucleotide -LRB- n = 55 -RRB- , containing the IRE and flanking regions -LRB- FL -RRB- , and natural ferritin mRNA . 27711752 1 1,10-phenanthrolinefuroxan 171,197 COX-2 271,276 1,10-phenanthrolinefuroxan COX-2 null 4513 Chemical Gene activities|amod|START_ENTITY supported|nmod|activities supported|nmod|inhibition inhibition|nmod|pathway pathway|compound|END_ENTITY UNASSIGNED : Zinc -LRB- ii -RRB- - NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway . 126324 2 1,10-phenanthrolines 420,440 COR1 600,604 1,10-phenanthrolines COR1 null 20962(Tax:10090) Chemical Gene joined|nsubjpass|START_ENTITY joined|nmod|form form|conj|R1CON R1CON|dep|END_ENTITY In the first series two 1,10-phenanthrolines -LRB- R1 -RRB- were joined at the 2 position to form four compounds : R1CO-c-N -LRB- CH2CH2 -RRB- 2N-COR1 , R1CONH-1 ,2 - C6H10-NHCOR1 , R1CONH-1 ,2 - C6H4-NHCOR1 , and R1CON -LRB- CH3 -RRB- -LRB- CH2 -RRB- 2N -LRB- CH3 -RRB- COR1 . 15052735 3 1,10-phenantroline 651,669 ADH 598,601 1,10-phenantroline ADH null 78959(Tax:10116) Chemical Gene 4-methylpyrazole|conj|START_ENTITY END_ENTITY|amod|4-methylpyrazole The aim of this investigation was to check the influence of some effective inhibitors of ADH and MEOS : 4-methylpyrazole , cimetidine , EDTA and 1,10-phenantroline on the activity of catalase with methanol as a substrate and the comparison with 3-amino-1 ,2,4 - triasole . 15052735 3 1,10-phenantroline 651,669 catalase 689,697 1,10-phenantroline catalase null 24248(Tax:10116) Chemical Gene 4-methylpyrazole|conj|START_ENTITY ADH|amod|4-methylpyrazole ADH|nmod|activity activity|nmod|END_ENTITY The aim of this investigation was to check the influence of some effective inhibitors of ADH and MEOS : 4-methylpyrazole , cimetidine , EDTA and 1,10-phenantroline on the activity of catalase with methanol as a substrate and the comparison with 3-amino-1 ,2,4 - triasole . 15052735 9 1,10-phenantroline 1406,1424 catalase 1447,1455 1,10-phenantroline catalase null 24248(Tax:10116) Chemical Gene 4-Methylpyrazole|amod|START_ENTITY END_ENTITY|nsubj|4-Methylpyrazole 4-Methylpyrazole , EDTA , 1,10-phenantroline and aminotriasole are catalase competitive inhibitors and cimetidine is non-competitive inhibitor . 8087866 7 1,10-phenantroline 1170,1188 CD16 1258,1262 1,10-phenantroline CD16 null 2214 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|nummod|END_ENTITY The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding . 8087866 7 1,10-phenantroline 1170,1188 CD16 1289,1293 1,10-phenantroline CD16 null 2214 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|acl|induced induced|nmod|crosslinking crosslinking|compound|END_ENTITY The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding . 8087866 7 1,10-phenantroline 1170,1188 CD16 1431,1435 1,10-phenantroline CD16 null 2214 Chemical Gene inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|acl|induced induced|xcomp|suggesting suggesting|ccomp|requires requires|advcl|occurs occurs|nmod|PMA PMA|acl|mediated mediated|dobj|downregulation downregulation|compound|END_ENTITY The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding . 20582429 8 1,10-phenantroline 1540,1558 HSP70 1597,1602 1,10-phenantroline HSP70 null 3308 Chemical Gene melatonin|conj|START_ENTITY Addition|dep|melatonin inhibited|nsubj|Addition inhibited|nmod|END_ENTITY Addition of free radical scavengers -LRB- melatonin or 1,10-phenantroline -RRB- inhibited the MF-induced increase in HSP70 . 24463435 3 1,10-phenantroline 834,852 lipoxygenase 768,780 1,10-phenantroline lipoxygenase null 547836(Tax:3847) Chemical Gene Zn|amod|START_ENTITY exhibited|nmod|Zn tested|conj|exhibited tested|nmod|activity activity|conj|activity activity|nmod|END_ENTITY Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with -LSB- Zn -LRB- tolf -RRB- -LRB- 1,10-phenantroline -RRB- -RSB- being the most active compound . 1560018 5 1,10-phenantroline 965,983 PLP 788,791 1,10-phenantroline PLP null 24943(Tax:10116) Chemical Gene tetraacetic_acid|conj|START_ENTITY ethylenebis|amod|tetraacetic_acid have|nsubj|ethylenebis have|ccomp|has has|nsubj|acylesterase acylesterase|compound|END_ENTITY The myelin-associated PLP fatty acylesterase has no apparent requirements for divalent cations -LRB- Ca2 + , Mg2 + , Mn2 + -RRB- , and chelators such as EDTA , -LSB- ethylenebis -LRB- oxyethylenenitrilo -RRB- -RSB- tetraacetic_acid , and 1,10-phenantroline have little or no effect on enzyme activity . 9540792 5 1,10-phenantroline 505,523 proteinase 544,554 1,10-phenantroline proteinase null 100862683 Chemical Gene inactivated|conj|START_ENTITY inactivated|advcl|had had|nsubj|PMSF PMSF|amod|END_ENTITY NPS was completely inactivated with inhibitors , typical for metalloendopeptidases , EDTA and 1,10-phenantroline , whereas the serine proteinase inhibitor PMSF had no effect . 19346138 3 1,10-phenantroline 410,428 TIMP-2 458,464 1,10-phenantroline TIMP-2 null 21858(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|conj|insusceptible insusceptible|nmod|END_ENTITY Its activity is inhibited by 1,10-phenantroline and GM6001 , insusceptible to TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinases-2 -RRB- , and stimulated by ionomycin . 19346138 3 1,10-phenantroline 410,428 tissue_inhibitor_of_metalloproteinases-2 466,506 1,10-phenantroline tissue inhibitor of metalloproteinases-2 null 21858(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY inhibited|conj|insusceptible insusceptible|nmod|TIMP-2 TIMP-2|dep|END_ENTITY Its activity is inhibited by 1,10-phenantroline and GM6001 , insusceptible to TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinases-2 -RRB- , and stimulated by ionomycin . 10462513 5 1,10-phenathroline 884,902 LAP 845,848 1,10-phenathroline LAP null 51056 Chemical Gene EDTA|conj|START_ENTITY activity|amod|EDTA metallo-enzyme|nmod|activity metallo-enzyme|nsubj|END_ENTITY Gonyaulax LAP is a metallo-enzyme since EDTA and 1,10-phenathroline significantly inhibited activity . 14985069 4 1.10-phenatroline 712,729 Arginine-aminopeptidase 526,549 1.10-phenatroline Arginine-aminopeptidase null 81761(Tax:10116) Chemical Gene arginine|conj|START_ENTITY arginine|nsubj|RESULTS RESULTS|dep|END_ENTITY RESULTS : Arginine-aminopeptidase found in cardiac fibroblasts -LRB- Fb -RRB- was arginine and lysine specific , sensitive to various aminopeptidase -LRB- AP -RRB- inhibitors and to the inhibitor of metalloproteases , 1.10-phenatroline . 27952646 13 1,10-PM 1419,1426 MMP-7 1436,1441 1,10-PM MMP-7 null 4316 Chemical Gene levels|nummod|START_ENTITY levels|compound|END_ENTITY Treatment with 1,10-PM decrease MMP-7 levels -LRB- p < 0.005 -RRB- compared with untreated cells . 27952646 7 1,10-PM 932,939 MMP-7 883,888 1,10-PM MMP-7 null 4316 Chemical Gene monohydrate|appos|START_ENTITY monohydrate|amod|inhibitor inhibitor|amod|END_ENTITY Both cell lines were cultured for 72h with different concentrations of oxaliplatin , BAY11-7085 -LRB- inhibitor of NF-kB activation -RRB- , 0.01 mM of the MMP-7 inhibitor 1,10-Phenanthroline _ monohydrate -LRB- 1,10-PM -RRB- and 100 ng/ml of DX2 monoclonal antibody . 25343522 10 1,10-PT 1494,1501 Bcl-xL 1526,1532 1,10-PT Bcl-xL null 598 Chemical Gene blocked|nsubj|START_ENTITY blocked|dobj|cleavage cleavage|nmod|END_ENTITY Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels . 25343522 10 1,10-PT 1494,1501 Bim 1712,1715 1,10-PT Bim null 10018 Chemical Gene blocked|nsubj|START_ENTITY blocked|conj|increased increased|dobj|levels levels|nmod|Bcl-xL/Bim Bcl-xL/Bim|conj|complexes complexes|compound|END_ENTITY Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels . 25343522 10 1,10-PT 1494,1501 Mcl-1 1534,1539 1,10-PT Mcl-1 null 4170 Chemical Gene blocked|nsubj|START_ENTITY blocked|dobj|cleavage cleavage|nmod|Bcl-xL Bcl-xL|conj|END_ENTITY Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels . 25343522 10 1,10-PT 1494,1501 Mcl-1 1706,1711 1,10-PT Mcl-1 null 4170 Chemical Gene blocked|nsubj|START_ENTITY blocked|conj|increased increased|dobj|levels levels|nmod|Bcl-xL/Bim Bcl-xL/Bim|conj|complexes complexes|compound|END_ENTITY Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels . 22465714 2 1-111_amino_acids 369,386 b-catenin 302,311 1-111 amino acids b-catenin null 1499 Chemical Gene mapped|nmod|START_ENTITY mapped|nsubjpass|domain domain|amod|END_ENTITY The minimum b-catenin binding domain of p300 has been mapped to the N-terminus 1-111_amino_acids . 22465714 2 1-111_amino_acids 369,386 p300 330,334 1-111 amino acids p300 null 2033 Chemical Gene mapped|nmod|START_ENTITY mapped|nsubjpass|domain domain|nmod|END_ENTITY The minimum b-catenin binding domain of p300 has been mapped to the N-terminus 1-111_amino_acids . 27919363 10 11-11-deoxycortisol 2047,2066 LDL-C 1968,1973 11-11-deoxycortisol LDL-C null 22796 Chemical Gene dehydroepiandrostenedione|conj|START_ENTITY values|amod|dehydroepiandrostenedione change|nsubj|values decreased|advcl|change decreased|nmod|conjunction conjunction|nmod|levels levels|nmod|END_ENTITY However , peak TT and FT hormone levels decreased in conjunction with decreasing levels of LDL-C among the statin-treated patients , whereas dehydroepiandrostenedione and 11-11-deoxycortisol peak values did not change . 23249676 2 11,12,15-THETA 405,419 15-lipoxygenase 456,471 11,12,15-THETA 15-lipoxygenase null 246 Chemical Gene metabolites|nsubj|START_ENTITY metabolites|nmod|pathway pathway|amod|END_ENTITY 15 -LRB- S -RRB- - Hydroxy-11 ,12 - epoxyeicosatrienoic_acid -LRB- 15-H-11 ,12 - EETA -RRB- and 11 -LRB- R -RRB- ,12 -LRB- S -RRB- ,15 -LRB- S -RRB- - trihydroxyeicosatrienoic_acid -LRB- 11,12,15-THETA -RRB- are endothelial metabolites of the 15-lipoxygenase -LRB- 15-LO -RRB- pathway of arachidonic_acid metabolism and are EDHFs . 23186146 6 1,1,1,2,2-pentaphenylethane 1217,1244 Ph3E 1164,1168 1,1,1,2,2-pentaphenylethane Ph3E null 10338 Chemical Gene END_ENTITY|conj|START_ENTITY Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis . 23706493 4 11-12AA 715,722 MYG1 677,681 11-12AA MYG1 null 60314 Chemical Gene polymorphisms|nummod|START_ENTITY promoter|conj|polymorphisms promoter|nummod|END_ENTITY METHODS : Polymerase chain reaction-restriction fragment length polymorphism -LRB- PCR-RFLP -RRB- technique was used for genotyping of MYG1 -119 C/G promoter -LRB- rs1465073 -RRB- and 11-12AA / GC structural polymorphisms -LRB- rs1534284-rs1534283 ; Arg4Gln -RRB- in 846 vitiligo patients and 726 age-matched unaffected controls . 23706493 7 11-12AA 1099,1106 MYG1 1195,1199 11-12AA MYG1 null 60314 Chemical Gene polymorphism|nummod|START_ENTITY monogenic|nsubj|polymorphism monogenic|nmod|allele allele|nummod|END_ENTITY However , 11-12AA / GC structural polymorphism was prevalently monogenic in patients and controls with only MYG1 GC -LRB- 4Arg -RRB- allele being present . 1742324 9 11,12-alpha-ketol 1903,1920 SN1 1712,1715 11,12-alpha-ketol SN1 null 10991 Chemical Gene gamma-ketol|conj|START_ENTITY affording|xcomp|gamma-ketol 12,13-alpha-ketol|acl|affording formation|nmod|12,13-alpha-ketol resulting|nmod|formation nucleophilic|advcl|resulting nucleophilic|parataxis|group group|nsubj|SN2 SN2|conj|OH OH|compound|END_ENTITY Two distinct mechanisms of allene_oxide hydrolysis are proposed : -LRB- 1 -RRB- nucleophilic -LRB- SN2 or SN1 , OH - is an attacking group -RRB- substitution , resulting in formation of 12,13-alpha-ketol ; -LRB- 2 -RRB- electrophilic -LRB- SE-like -RRB- reaction initiated by protonation of oxirane , affording gamma-ketol and 11,12-alpha-ketol . 1742324 9 11,12-alpha-ketol 1903,1920 SN2 1705,1708 11,12-alpha-ketol SN2 null 92745 Chemical Gene gamma-ketol|conj|START_ENTITY affording|xcomp|gamma-ketol 12,13-alpha-ketol|acl|affording formation|nmod|12,13-alpha-ketol resulting|nmod|formation nucleophilic|advcl|resulting nucleophilic|parataxis|group group|nsubj|END_ENTITY Two distinct mechanisms of allene_oxide hydrolysis are proposed : -LRB- 1 -RRB- nucleophilic -LRB- SN2 or SN1 , OH - is an attacking group -RRB- substitution , resulting in formation of 12,13-alpha-ketol ; -LRB- 2 -RRB- electrophilic -LRB- SE-like -RRB- reaction initiated by protonation of oxirane , affording gamma-ketol and 11,12-alpha-ketol . 8384875 2 11-12-amino_acid 276,292 c-Fms 491,496 11-12-amino acid c-Fms null 1436 Chemical Gene phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|END_ENTITY Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind . 8384875 2 11-12-amino_acid 276,292 CSF-1 485,490 11-12-amino acid CSF-1 null 1435 Chemical Gene phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|c-Fms c-Fms|compound|END_ENTITY Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind . 8384875 2 11-12-amino_acid 276,292 IRS-1 525,530 11-12-amino acid IRS-1 null 3667 Chemical Gene phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|END_ENTITY Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind . 10822532 3 11,12-cyclopropylretinal 376,400 rhodopsin 316,325 11,12-cyclopropylretinal rhodopsin MESH:C050233 509933(Tax:9913) Chemical Gene analogues|amod|START_ENTITY studies|nmod|analogues determined|nmod|studies determined|nsubjpass|twist twist|nmod|bond bond|nmod|chromophore chromophore|nmod|END_ENTITY The absolute twist around the 12-s bond of the chromophore in rhodopsin has been determined by studies with 11-cis-locked 11,12-cyclopropylretinal analogues -LRB- 11S ,12 R -RRB- -2 and -LRB- 11R ,12 S -RRB- -3 , enantioselectively synthesized with the aid of an enzyme . 17885841 1 11,12-dehydrofalcarinol 277,300 Bean 197,201 11,12-dehydrofalcarinol Bean null 146227 Chemical Gene polyacetylenes|conj|START_ENTITY known|xcomp|polyacetylenes two|acl|known isolated|nmod|two isolated|nmod|extract extract|nmod|galls galls|nmod|END_ENTITY A new C -LRB- 17 -RRB- - polyacetylene , named hederyne_A -LRB- 1 -RRB- , has been isolated from the MeOH extract of galls of Hedera rhombea Bean -LRB- Araliaceae -RRB- , together with two known polyacetylenes , falcarindiol -LRB- 2 -RRB- and 11,12-dehydrofalcarinol -LRB- 3 -RRB- . 18805895 7 11,12-DHET 1994,2004 A2A_AR 2044,2050 11,12-DHET A2A AR CHEBI:63969 11540(Tax:10090) Chemical Gene 14,15-DHET|nummod|START_ENTITY DHETs|dep|14,15-DHET dihydroxyeicosatrienoic_acids|dep|DHETs levels|nmod|dihydroxyeicosatrienoic_acids found|nsubjpass|levels found|nmod|+ +|compound|END_ENTITY Higher levels of dihydroxyeicosatrienoic_acids -LRB- DHETs ; 14,15-DHET , 11,12-DHET , and 8,9-DHET , P < 0.05 -RRB- were found in A2A_AR + / + versus A2A_AR -LRB- - / - -RRB- aortae . 18805895 7 11,12-DHET 1994,2004 A2A_AR 2061,2067 11,12-DHET A2A AR CHEBI:63969 11540(Tax:10090) Chemical Gene 14,15-DHET|nummod|START_ENTITY DHETs|dep|14,15-DHET dihydroxyeicosatrienoic_acids|dep|DHETs levels|nmod|dihydroxyeicosatrienoic_acids found|nsubjpass|levels found|nmod|+ +|nmod|aortae aortae|compound|END_ENTITY Higher levels of dihydroxyeicosatrienoic_acids -LRB- DHETs ; 14,15-DHET , 11,12-DHET , and 8,9-DHET , P < 0.05 -RRB- were found in A2A_AR + / + versus A2A_AR -LRB- - / - -RRB- aortae . 11483698 15 11,12-DHET 1688,1698 BK_channel 1713,1723 11,12-DHET BK channel CHEBI:63969 83731(Tax:10116) Chemical Gene alter|nsubj|START_ENTITY alter|dobj|conductance conductance|amod|END_ENTITY Single channel kinetic analysis indicated that 11,12-DHET did not alter BK_channel conductance but did reduce the first latency of BK_channel openings in response to a voltage step . 11483698 15 11,12-DHET 1688,1698 BK_channel 1772,1782 11,12-DHET BK channel CHEBI:63969 83731(Tax:10116) Chemical Gene alter|nsubj|START_ENTITY alter|conj|reduce reduce|dobj|latency latency|nmod|openings openings|compound|END_ENTITY Single channel kinetic analysis indicated that 11,12-DHET did not alter BK_channel conductance but did reduce the first latency of BK_channel openings in response to a voltage step . 27663770 11 11,12-DHET 1698,1708 CYP2C19 1593,1600 11,12-DHET CYP2C19 CHEBI:63969 1557 Chemical Gene were|dep|START_ENTITY were|nsubj|levels levels|nmod|PM PM|compound|END_ENTITY In MVA group , DHET levels for CYP2C19 PM were significantly lower than that of non-PM -LSB- 10.9 1.64 vs. 14.2 5.39 ng/ml , P = 0.019 -LRB- 11,12-DHET -RRB- ; 15.2 4.39 vs. 17.9 4.73 ng/ml , P = 0.025 -LRB- 14,15-DHET -RRB- -RSB- . 28616567 9 11,12-DHET 1431,1441 CYP2C19 1319,1326 11,12-DHET CYP2C19 CHEBI:63969 1557 Chemical Gene P|appos|START_ENTITY 4.58|appos|P non-PM|dep|4.58 that|nmod|non-PM lower|nmod|that lower|nsubj|levels levels|nmod|PM PM|compound|END_ENTITY Moreover , DHET levels in CYP2C19 PM were significantly lower than that of non-PM -LRB- 10.4 4.58 vs. 15.6 11.1 ng/mL , P = 0.003 -LRB- 11,12-DHET -RRB- ; 12.1 3.79 vs. 17.3 6.49 ng/mL , P = 0.019 -LRB- 14,15-DHET -RRB- -RRB- . 22678950 4 11,12-diesters 988,1002 C-11 1083,1087 11,12-diesters C-11 null 51728 Chemical Gene ions|nmod|START_ENTITY dissociation|nmod|ions revealed|nsubj|dissociation revealed|dobj|losses losses|nmod|first first|nmod|END_ENTITY Sequential in-trap collision-induced dissociation of -LSB- M + Na -RSB- -LRB- + -RRB- ions from 11,12-diesters revealed consistent preferred losses of substituents first from C-12 , then from C-11 , followed by losses of monosaccharide fragments from the C-3_tri - _ and_tetrasaccharide substituents . 2546405 4 11,12-diHETE 578,590 glutathione_S-transferase 531,556 11,12-diHETE glutathione S-transferase MESH:C410128 58962(Tax:10116) Chemical Gene gland|amod|START_ENTITY isomer|nmod|gland END_ENTITY|conj|isomer In addition to the above nonenzymic products , 11,12-LTA4 was converted to 11,12-LTC4 by the rat liver glutathione_S-transferase , and to an isomer of 11,12-diHETE by homogenates of the guinea_pig adrenal gland and liver . 9348439 4 11,12-dihydrodiol 1322,1339 CD-1 1159,1163 11,12-dihydrodiol CD-1 null 25109(Tax:10116) Chemical Gene enantiomers|amod|START_ENTITY configuration|nmod|enantiomers depends|nmod|configuration depends|ccomp|revealed revealed|nsubj|Incubations Incubations|nmod|microsomes microsomes|conj|mice mice|compound|END_ENTITY Incubations with liver microsomes of Sprague-Dawley_rats and CD-1 mice pretreated with Aroclor_1254 revealed that the enzymatic conversion to the fjord region DB -LSB- a , l -RSB- PDE strongly depends on the absolute configuration of the 11,12-dihydrodiol enantiomers . 15223354 3 11,12-dihydrodiol 735,752 DBP 507,510 11,12-dihydrodiol DBP MESH:C529145 13170(Tax:10090) Chemical Gene derivative|dep|START_ENTITY formed|dobj|derivative discussed|ccomp|formed discussed|nmod|metabolites metabolites|nmod|END_ENTITY As ultimate genotoxic metabolites of DBP two electrophilically reactive species are discussed : -LRB- i -RRB- radical cations generated by one-electron oxidation , and -LRB- ii -RRB- fjord region dihydrodiol_epoxides formed via the trans-11 ,12 - dihydroxy 11,12-dihydro derivative of DBP -LRB- 11,12-dihydrodiol -RRB- . 15223354 3 11,12-dihydrodiol 735,752 DBP 730,733 11,12-dihydrodiol DBP MESH:C529145 13170(Tax:10090) Chemical Gene derivative|dep|START_ENTITY derivative|nmod|END_ENTITY As ultimate genotoxic metabolites of DBP two electrophilically reactive species are discussed : -LRB- i -RRB- radical cations generated by one-electron oxidation , and -LRB- ii -RRB- fjord region dihydrodiol_epoxides formed via the trans-11 ,12 - dihydroxy 11,12-dihydro derivative of DBP -LRB- 11,12-dihydrodiol -RRB- . 7910485 3 11,12-EET 613,622 2B1 516,519 11,12-EET 2B1 MESH:C046783 286954(Tax:10116) Chemical Gene produced|dobj|START_ENTITY acid|dep|produced produced|nsubj|acid produced|dep|P-450 P-450|dep|END_ENTITY P-450 2B1 produced predominantly 14,15-epoxyeicosatrienoic _ acid -LRB- EET -RRB- , while P-450 2B1-WM produced the 11,12-EET as the major product . 19401302 8 11,12-EET 1430,1439 Akt 1381,1384 11,12-EET Akt MESH:C046783 11651(Tax:10090) Chemical Gene perfused|nmod|START_ENTITY hearts|acl|perfused found|nmod|hearts found|nsubjpass|expression expression|nmod|epsilon epsilon|conj|END_ENTITY Increased expression of phosphorylated protein kinase C epsilon and Akt were found in WT hearts perfused with either 11,12-EET or rBNP , while mitochondrial glycogen synthase kinase-3beta was significantly lower in the same samples . 28587983 6 11,12-EET 923,932 Ang 980,983 11,12-EET Ang MESH:C046783 283 Chemical Gene treatment|nmod|START_ENTITY attenuated|nsubj|treatment attenuated|dobj|inflammation inflammation|acl|induced induced|nmod|II II|compound|END_ENTITY Furthermore , treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-kB nuclear translocation , increased IkBa expression and decreased_inflammation factor level . 28554983 7 11,12-EET 1232,1241 Ang_II 1126,1132 11,12-EET Ang II MESH:C046783 11606(Tax:10090) Chemical Gene inhibited|nmod|START_ENTITY pathway|acl:relcl|inhibited activation|nmod|pathway associated|nmod|activation associated|nsubjpass|activation activation|acl|induced induced|nmod|END_ENTITY In in vitro studies , cardiac fibroblast activation , proliferation , migration , and collagen production induced by Ang_II were associated with activation of the Ga12/13/RhoA / ROCK pathway , which was inhibited by exogenous 11,12-EET . 21846841 5 11,12-EET 791,800 caspase-3 913,922 11,12-EET caspase-3 MESH:C046783 836 Chemical Gene prevented|nsubj|START_ENTITY prevented|dobj|activation activation|amod|kinase kinase|conj|END_ENTITY 11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase , c-Jun NH -LRB- 2 -RRB- - terminal kinase , caspase-3 , and caspase-9 . 21846841 5 11,12-EET 791,800 caspase-9 928,937 11,12-EET caspase-9 MESH:C046783 842 Chemical Gene prevented|nsubj|START_ENTITY prevented|dobj|activation activation|amod|kinase kinase|conj|END_ENTITY 11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase , c-Jun NH -LRB- 2 -RRB- - terminal kinase , caspase-3 , and caspase-9 . 21846841 4 11,12-EET 649,658 catalase 745,753 11,12-EET catalase MESH:C046783 847 Chemical Gene pretreatment|nummod|START_ENTITY increased|nsubj|pretreatment increased|dobj|expression expression|nmod|superoxide superoxide|amod|dismutase dismutase|conj|END_ENTITY 11,12-EET pretreatment increased expression of the antioxidant enzymes superoxide dismutase and catalase and inhibited ATO-induced apoptosis . 15652503 1 11,12-EET 220,229 CYP2C 137,142 11,12-EET CYP2C MESH:C046783 1559 Chemical Gene oxidized|nmod|START_ENTITY oxidized|nmod|cytochromes_P450_2C cytochromes_P450_2C|appos|END_ENTITY Arachidonic_acid is oxidized by cytochromes_P450_2C -LRB- CYP2C -RRB- to epoxyeicosatrienoic_acids -LRB- EETs -RRB- , possessing vasoactive properties , with 11,12-EET as the endothelium derived hyperpolarization factor . 19073823 3 11,12-EET 604,613 CYP2C23 535,542 11,12-EET CYP2C23 MESH:C046783 83790(Tax:10116) Chemical Gene levels|appos|START_ENTITY increased|dobj|levels stimulated|conj|increased stimulated|dobj|expression expression|nmod|END_ENTITY By Western blot analysis , high dietary K stimulated the expression of CYP2C23 but not CYP2J2 and increased 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- levels in isolated rat CCD tubules . 17872452 7 11,12-EET 1428,1437 CYP2C9 1242,1248 11,12-EET CYP2C9 MESH:C046783 1559 Chemical Gene mimicked|nmod|START_ENTITY prevented|conj|mimicked membrane|acl:relcl|prevented areas|nmod|membrane enhanced|nmod|areas enhanced|nsubj|overexpression overexpression|nmod|END_ENTITY Indeed , overexpression of CYP2C9 enhanced the agonist-induced translocation of a TrpC6-V5 fusion protein to caveolin-1-rich areas of the endothelial cell membrane , which was prevented by Rp-cAMPS and mimicked by 11,12-EET . 19073823 3 11,12-EET 604,613 CYP2J2 551,557 11,12-EET CYP2J2 MESH:C046783 65210(Tax:10116) Chemical Gene levels|appos|START_ENTITY increased|dobj|levels stimulated|conj|increased stimulated|dobj|expression expression|nmod|CYP2C23 CYP2C23|conj|END_ENTITY By Western blot analysis , high dietary K stimulated the expression of CYP2C23 but not CYP2J2 and increased 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- levels in isolated rat CCD tubules . 24058654 0 11,12-EET 33,42 CYP2J2 10,16 11,12-EET CYP2J2 MESH:C046783 1573 Chemical Gene END_ENTITY|conj|START_ENTITY Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis : a role for CYP2J2_deficiency in the pathogenesis of Crohn 's _ disease ? 24058654 6 11,12-EET 645,654 CYP2J2 612,618 11,12-EET CYP2J2 MESH:C046783 1573 Chemical Gene products|nummod|START_ENTITY arachidonic_acid|dobj|products arachidonic_acid|nsubj|END_ENTITY The CYP2J2 arachidonic_acid products 11,12-EET and 14,15-EET inhibited LPS induced TNFa release . 24058654 8 11,12-EET 999,1008 CYP2J2 889,895 11,12-EET CYP2J2 MESH:C046783 1573 Chemical Gene reversed|nmod|START_ENTITY phagocytosis|acl:relcl|reversed inhibitor|dobj|phagocytosis inhibitor|nsubj|inhibition inhibition|acl|using using|dobj|SKF525A SKF525A|conj|END_ENTITY Epoxygenase inhibition using a non-selective inhibitor SKF525A or a selective CYP2J2 inhibitor Compound 4 , inhibited E. _ coli particle phagocytosis , which could be specifically reversed by 11,12-EET . 24486707 5 11,12-EET 977,986 CYP2J4 951,957 11,12-EET CYP2J4 MESH:C046783 65210(Tax:10116) Chemical Gene upregulated|nmod|START_ENTITY upregulated|nsubjpass|expression expression|nmod|END_ENTITY In addition , the ox-LDL-induced expression of CYP2J4 was upregulated by 11,12-EET and 14,15-EET -LRB- 1 M -RRB- . 12124379 5 11,12-EET 1044,1053 CYP4A2 1007,1013 11,12-EET CYP4A2 MESH:C046783 1579 Chemical Gene preferred|dobj|START_ENTITY preferred|nsubj|END_ENTITY CYP4A1 exhibited a preference for 8,9-EET , whereas CYP4A2 , CYP4A3 , and CYP4A8 preferred 11,12-EET . 16141533 2 11,12-EET 748,757 CYP4A2 762,768 11,12-EET CYP4A2 MESH:C046783 1579 Chemical Gene eicosatrienoic_acid|appos|START_ENTITY eicosatrienoic_acid|nmod|END_ENTITY The IC50 value for production of 11,12-epoxy-5 ,8,14 - eicosatrienoic_acid -LRB- 11,12-EET -RRB- by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM , respectively . 12876297 1 11,12-EET 255,264 Cytochrome_P-450_monooxygenase 125,155 11,12-EET Cytochrome P-450 monooxygenase MESH:C046783 313375(Tax:10116) Chemical Gene acid|appos|START_ENTITY metabolites|nmod|acid possess|nsubj|metabolites arachidonic_acid|acl:relcl|possess END_ENTITY|dep|arachidonic_acid Cytochrome_P-450_monooxygenase -LRB- epoxygenase -RRB- - derived arachidonic_acid -LRB- AA -RRB- metabolites , including 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- , possess anti-inflammatory and antipyretic properties . 15652503 1 11,12-EET 220,229 cytochromes_P450_2C 116,135 11,12-EET cytochromes P450 2C MESH:C046783 1559 Chemical Gene oxidized|nmod|START_ENTITY oxidized|nmod|END_ENTITY Arachidonic_acid is oxidized by cytochromes_P450_2C -LRB- CYP2C -RRB- to epoxyeicosatrienoic_acids -LRB- EETs -RRB- , possessing vasoactive properties , with 11,12-EET as the endothelium derived hyperpolarization factor . 16234312 13 11,12-EET 1687,1696 ENaC 1707,1711 11,12-EET ENaC MESH:C046783 24768(Tax:10116) Chemical Gene acid|appos|START_ENTITY inhibits|nsubj|acid inhibits|dobj|activity activity|amod|END_ENTITY Because 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- inhibits ENaC activity in the CCD -LRB- Wei Y , Lin DH , Kemp R , Yaddanapudi GSS , Nasjletti A , Falck JR , and Wang WH . 16234312 14 11,12-EET 1868,1877 ENaC 1918,1922 11,12-EET ENaC MESH:C046783 24768(Tax:10116) Chemical Gene role|nmod|START_ENTITY examined|dobj|role examined|advcl|mediating mediating|nmod|END_ENTITY J Gen Physiol 124 : 719-727 , 2004 -RRB- , we examined the role of 11,12-EET in mediating the effect of adenosine on ENaC . 16234312 15 11,12-EET 1936,1945 ENaC 1956,1960 11,12-EET ENaC MESH:C046783 24768(Tax:10116) Chemical Gene Addition|nmod|START_ENTITY inhibited|nsubj|Addition inhibited|dobj|channels channels|amod|END_ENTITY Addition of 11,12-EET inhibited ENaC channels in the CCD in which adenosine-induced inhibition was blocked by AACOCF3 . 16234312 16 11,12-EET 2198,2207 ENaC 2079,2083 11,12-EET ENaC MESH:C046783 24768(Tax:10116) Chemical Gene mediated|nmod|START_ENTITY inhibits|conj|mediated inhibits|dobj|activity activity|amod|END_ENTITY We conclude that adenosine inhibits ENaC activity by stimulation of the A -LRB- 1 -RRB- adenosine receptor in the CCD and that the effect of adenosine is mediated by 11,12-EET . 18340006 3 11,12-EET 521,530 EphB4 575,580 11,12-EET EphB4 MESH:C046783 13846(Tax:10090) Chemical Gene time-dependently|compound|START_ENTITY stimulation|nmod|time-dependently overexpression|conj|stimulation increased|nsubj|overexpression increased|dobj|expression expression|amod|END_ENTITY METHODS AND RESULTS : CYP2C9 overexpression as well as stimulation with 11,12-EET -LRB- up to 48 hours -RRB- time-dependently increased EphB4 expression in endothelial cells . 11510882 6 11,12-EET 1370,1379 Erk1/2 1414,1420 11,12-EET Erk1/2 MESH:C046783 5595;5594 Chemical Gene product|appos|START_ENTITY activated|nsubj|product activated|dobj|kinases kinases|conj|END_ENTITY The CYP 2C product 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- also activated tyrosine kinases , Erk1/2 and p38_MAP_kinase . 24486707 4 11,12-EET 686,695 E-selectin 809,819 11,12-EET E-selectin MESH:C046783 25544(Tax:10116) Chemical Gene pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|conj|END_ENTITY We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner . 27966642 4 11,12-EET 572,581 ICAM1 846,851 11,12-EET ICAM1 MESH:C046783 3383 Chemical Gene addition|nmod|START_ENTITY addition|dep|product product|nmod|hydrolysis hydrolysis|conj|expression expression|nummod|END_ENTITY Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression . 24486707 4 11,12-EET 686,695 ICAM-1 800,806 11,12-EET ICAM-1 MESH:C046783 25464(Tax:10116) Chemical Gene pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|dep|END_ENTITY We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner . 27966642 4 11,12-EET 572,581 ICAM-1 725,731 11,12-EET ICAM-1 MESH:C046783 3383 Chemical Gene addition|nmod|START_ENTITY addition|acl:relcl|dodecanoic_acid dodecanoic_acid|ccomp|inhibited inhibited|dobj|expression expression|amod|VCAM-1 VCAM-1|conj|END_ENTITY Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression . 28587983 6 11,12-EET 923,932 IkBa 1052,1056 11,12-EET IkBa MESH:C046783 4792 Chemical Gene treatment|nmod|START_ENTITY attenuated|nsubj|treatment attenuated|dobj|inflammation inflammation|acl|induced induced|advcl|evidenced evidenced|nmod|translocation translocation|conj|expression expression|amod|END_ENTITY Furthermore , treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-kB nuclear translocation , increased IkBa expression and decreased_inflammation factor level . 24486707 4 11,12-EET 686,695 intercellular_adhesion_molecule-1 765,798 11,12-EET intercellular adhesion molecule-1 MESH:C046783 25464(Tax:10116) Chemical Gene pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|END_ENTITY We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner . 24486707 4 11,12-EET 686,695 MCP-1 861,866 11,12-EET MCP-1 MESH:C046783 24770(Tax:10116) Chemical Gene pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|appos|END_ENTITY We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner . 28319086 9 11,12-EET 992,1001 MMP-9 1150,1155 11,12-EET MMP-9 MESH:C046783 17395(Tax:10090) Chemical Gene treatment|nummod|START_ENTITY decreased|nsubj|treatment decreased|advcl|resulting resulting|nmod|production production|nmod|cytokines cytokines|conj|expression expression|compound|END_ENTITY 11,12-EET treatment decreased neutrophil and macrophage infiltration to the wound sites , resulting in reduced production of inflammatory cytokines , decreased MMP-9 expression , and increased collagen accumulation in the granulation tissues of ob/ob mice . 24486707 4 11,12-EET 686,695 monocyte_chemoattractant_protein-1 825,859 11,12-EET monocyte chemoattractant protein-1 MESH:C046783 24770(Tax:10116) Chemical Gene pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|conj|END_ENTITY We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner . 24486707 8 11,12-EET 1375,1384 NF-kB 1459,1464 11,12-EET NF-kB MESH:C046783 309165(Tax:10116) Chemical Gene suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|conj|activation activation|nmod|END_ENTITY In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 . 23029390 7 11,12-EET 1312,1321 NOS 1236,1239 11,12-EET NOS MESH:C046783 18125(Tax:10090) Chemical Gene induced|nummod|START_ENTITY depolarization|nmod:npmod|induced channels|amod|depolarization dye|appos|channels loaded|nmod|dye inhibitors|conj|loaded inhibitors|nsubj|cells cells|acl|treated treated|nmod|END_ENTITY In pulmonary artery smooth muscle cells treated with NOS and COX inhibitors and loaded with the potentiometric dye , di-8-ANEPPS , 11,12-EET induced depolarization while the BK channel opener NS1619 elicited hyperpolarization indicating there was no effect of the EET on classical plasma membrane BK channels . 24486707 8 11,12-EET 1375,1384 p38 1415,1418 11,12-EET p38 MESH:C046783 81649(Tax:10116) Chemical Gene suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|nmod|END_ENTITY In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 . 11510882 6 11,12-EET 1370,1379 p38_MAP_kinase 1425,1439 11,12-EET p38 MAP kinase MESH:C046783 1432 Chemical Gene product|appos|START_ENTITY activated|nsubj|product activated|dobj|kinases kinases|conj|END_ENTITY The CYP 2C product 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- also activated tyrosine kinases , Erk1/2 and p38_MAP_kinase . 24486707 8 11,12-EET 1375,1384 p65 1466,1469 11,12-EET p65 MESH:C046783 25716(Tax:10116) Chemical Gene suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|conj|activation activation|nmod|NF-kB NF-kB|appos|END_ENTITY In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 . 28554983 8 11,12-EET 1309,1318 RhoA 1277,1281 11,12-EET RhoA MESH:C046783 11848(Tax:10090) Chemical Gene exerted|nmod|START_ENTITY exerted|nsubj|silencing silencing|nmod|Ga12/13 Ga12/13|conj|END_ENTITY Moreover , silencing of Ga12/13 or RhoA exerted similar effects as 11,12-EET . 26201599 4 11,12-EET 708,717 runx1 800,805 11,12-EET runx1 MESH:C046783 58126(Tax:7955) Chemical Gene promoted|nsubj|START_ENTITY promoted|advcl|activating activating|xcomp|autonomous autonomous|nsubj|AP-1 AP-1|conj|program program|amod|END_ENTITY The pro-haematopoietic effects of EETs were conserved in the developing zebrafish embryo , where 11,12-EET promoted HSPC specification by activating a unique activator protein 1 -LRB- AP-1 -RRB- and runx1 transcription program autonomous to the haemogenic endothelium . 20595684 10 11,12-EET 1682,1691 sEH 1754,1757 11,12-EET sEH MESH:C046783 65030(Tax:10116) Chemical Gene effect|conj|START_ENTITY enhances|dobj|effect enhances|nmod|activity activity|conj|activity activity|compound|END_ENTITY In conclusion , high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity , respectively . 27079253 5 11,12-EET 855,864 sEH 833,836 11,12-EET sEH MESH:C046783 2053 Chemical Gene reduced|nsubj|START_ENTITY reduced|advcl|stabilized stabilized|nmod|inhibitor inhibitor|compound|END_ENTITY APPROACH/RESULTS : When stabilized by an sEH inhibitor -LRB- seHi -RRB- , 11,12-EET at a physiologically low dose -LRB- 0.1 nM -RRB- reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells -LRB- HAEC -RRB- and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFa . 28488585 4 11,12-EET 814,823 sEH 791,794 11,12-EET sEH MESH:C046783 13850(Tax:10090) Chemical Gene AUDA|conj|START_ENTITY AUDA|compound|END_ENTITY In addition , sEH inhibitor AUDA and 11,12-EET also decreased endothelial hyper-permeability in the in-vitro study . 28881620 4 11,12-EET 814,823 sEH 791,794 11,12-EET sEH MESH:C046783 13850(Tax:10090) Chemical Gene AUDA|conj|START_ENTITY AUDA|compound|END_ENTITY In addition , sEH inhibitor AUDA and 11,12-EET also decreased endothelial hyper-permeability in the in-vitro study . 25618409 9 11,12-EET 1638,1647 TGF-b1 1696,1702 11,12-EET TGF-b1 MESH:C046783 21803(Tax:10090) Chemical Gene treated|nmod|START_ENTITY cardiomyocytes|acl|treated media|nmod|cardiomyocytes inhibited|nsubj|media inhibited|dobj|activation activation|nmod|fibroblasts fibroblasts|conj|/ /|compound|END_ENTITY Furthermore , conditioned media from neonatal cardiomyocytes treated with 11,12-EET inhibited activation of cardiac fibroblasts and TGF-b1 / smad pathway . 27079253 5 11,12-EET 855,864 TNFa 1106,1110 11,12-EET TNFa MESH:C046783 7124 Chemical Gene reduced|nsubj|START_ENTITY reduced|advcl|combined combined|nmod|END_ENTITY APPROACH/RESULTS : When stabilized by an sEH inhibitor -LRB- seHi -RRB- , 11,12-EET at a physiologically low dose -LRB- 0.1 nM -RRB- reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells -LRB- HAEC -RRB- and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFa . 20163540 6 11,12-EET 1053,1062 TRPV4 1131,1136 11,12-EET TRPV4 MESH:C046783 66026(Tax:10116) Chemical Gene effect|nmod|START_ENTITY prevented|nsubjpass|effect prevented|nmod|blockade blockade|conj|blockade blockade|nmod|END_ENTITY The beneficial effect of 11,12-EET was not prevented by blockade of K -LRB- ATP -RRB- channels nor by blockade of TRPV4 . 27966642 4 11,12-EET 572,581 VCAM1 836,841 11,12-EET VCAM1 MESH:C046783 7412 Chemical Gene addition|nmod|START_ENTITY addition|dep|product product|nmod|hydrolysis hydrolysis|conj|END_ENTITY Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression . 14592496 0 11,12-EET 32,41 VCAM-1 104,110 11,12-EET VCAM-1 MESH:C046783 7412 Chemical Gene acid|appos|START_ENTITY acid|dep|determinants determinants|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- : structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression . 27966642 4 11,12-EET 572,581 VCAM-1 714,720 11,12-EET VCAM-1 MESH:C046783 7412 Chemical Gene addition|nmod|START_ENTITY addition|acl:relcl|dodecanoic_acid dodecanoic_acid|ccomp|inhibited inhibited|dobj|expression expression|amod|END_ENTITY Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression . 16439348 2 11,12-epoxy 614,625 C-4 639,642 11,12-epoxy C-4 null 720 Chemical Gene taxoids|amod|START_ENTITY taxoids|nmod|bond bond|compound|END_ENTITY Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata . 2546405 4 11,12-LTC4 503,513 glutathione_S-transferase 531,556 11,12-LTC4 glutathione S-transferase null 58962(Tax:10116) Chemical Gene converted|nmod|START_ENTITY converted|nmod|END_ENTITY In addition to the above nonenzymic products , 11,12-LTA4 was converted to 11,12-LTC4 by the rat liver glutathione_S-transferase , and to an isomer of 11,12-diHETE by homogenates of the guinea_pig adrenal gland and liver . 23186146 6 1,1,1,2-Ph4E 1198,1210 Ph3E 1164,1168 1,1,1,2-Ph4E Ph3E null 10338 Chemical Gene END_ENTITY|conj|START_ENTITY Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis . 1356728 0 1,1,1,2-tetrafluoroethane 98,123 cytochrome_P-450_2E1 17,37 1,1,1,2-tetrafluoroethane cytochrome P-450 2E1 MESH:C063006 1571 Chemical Gene role|nmod|START_ENTITY role|nmod|oxidation oxidation|amod|END_ENTITY Dominant role of cytochrome_P-450_2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane . 24565651 1 1,1,1,2-tetrafluoroethane 188,213 Endo 178,182 1,1,1,2-tetrafluoroethane Endo MESH:C063006 79694 Chemical Gene Ice|dep|START_ENTITY Ice|compound|END_ENTITY INTRODUCTION : The goal of this project was to evaluate the performance of dental pulp sensibility testing with Endo Ice -LRB- 1,1,1,2-tetrafluoroethane -RRB- and an electric pulp tester -LRB- EPT -RRB- and to determine the effect of several variables on the reliability of these tests . 17909872 0 1,1,1,2-tetrafluoroethane 48,73 lipase 26,32 1,1,1,2-tetrafluoroethane lipase MESH:C063006 26302740 Chemical Gene Stability|nmod|START_ENTITY Stability|nmod|END_ENTITY Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane -LRB- R134a -RRB- . 17909872 1 1,1,1,2-tetrafluoroethane 196,221 lipase 136,142 1,1,1,2-tetrafluoroethane lipase MESH:C063006 26302740 Chemical Gene Candida_antarctica|nmod|START_ENTITY END_ENTITY|nmod|Candida_antarctica The stability and activity of commercial immobilized lipase from Candida_antarctica -LRB- Novozym 435 -RRB- in subcritical 1,1,1,2-tetrafluoroethane -LRB- R134a -RRB- was investigated . 26772162 0 1,1,1,3,3,3-hexafluoro-2-propanol 92,125 beta_amyloid_peptide_1-42 63,88 1,1,1,3,3,3-hexafluoro-2-propanol beta amyloid peptide 1-42 MESH:C001337 351 Chemical Gene END_ENTITY|nmod|START_ENTITY Nuclear magnetic resonance evidence for the dimer formation of beta_amyloid_peptide_1-42 in 1,1,1,3,3,3-hexafluoro-2-propanol . 27805203 3 1,1,1,3,3,3-hexafluoro-2-propanol 517,550 C-5 396,399 1,1,1,3,3,3-hexafluoro-2-propanol C-5 MESH:C001337 727 Chemical Gene formed|advcl|START_ENTITY obtained|advcl|formed obtained|nsubjpass|Tris-substituted_pyrazoles Tris-substituted_pyrazoles|acl|having having|dobj|functionality functionality|nmod|position position|compound|END_ENTITY Tris-substituted_pyrazoles , having a ketone functionality at the C-5 position , were obtained as the major product in ethanol , while di-substituted_pyrazoles were predominantly formed in 1,1,1,3,3,3-hexafluoro-2-propanol . 24847058 5 1,1,1,3,3,3-hexafluoro-2-propanol 739,772 insulin 672,679 1,1,1,3,3,3-hexafluoro-2-propanol insulin MESH:C001337 3630 Chemical Gene 2,2,2-trifluoroethanol|conj|START_ENTITY concentrations|acl|2,2,2-trifluoroethanol using|dobj|concentrations END_ENTITY|acl|using We studied the alcohol-induced amyloid_fibrillation of insulin using various concentrations of 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoro-2-propanol at pH 2.0 and 4.8 . 16004450 1 1,1,1,3,3,3-hexafluoro-2-propanol 345,378 PLCL 237,241 1,1,1,3,3,3-hexafluoro-2-propanol PLCL MESH:C001337 5334 Chemical Gene using|dobj|START_ENTITY co-electrospun|dep|using co-electrospun|nsubj|poly poly|appos|END_ENTITY Functionally designed elastomeric nanofiber fabrics made of the equimolar copolyester , poly -LRB- L-lactide-co-epsilon-caprolactone -RRB- -LRB- PLCL -RRB- , with type I collagen or the tri-n-butylamine salt of heparin -LRB- heparin-TBA -RRB- were co-electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- as a solvent . 20401926 1 1,1,1,3,3,3-hexafluoro-2-propanol 227,260 Slc11a1 183,190 1,1,1,3,3,3-hexafluoro-2-propanol Slc11a1 MESH:C001337 6556 Chemical Gene experiments|amod|START_ENTITY studied|nmod|experiments studied|nsubjpass|structure structure|nmod|corresponding corresponding|nmod|domain domain|nmod|END_ENTITY The structure and self-assembly of the peptide corresponding to the third transmembrane domain -LRB- TMD3 -RRB- of Slc11a1 and its E139A mutant are studied in 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- aqueous solution by NMR and CD experiments . 22499248 3 1,1,1,3,3,3-hexafluoro-2-propanol 586,619 SPI 518,521 1,1,1,3,3,3-hexafluoro-2-propanol SPI MESH:C001337 1113 Chemical Gene dissolved|advcl|START_ENTITY isolate|acl|dissolved isolate|appos|END_ENTITY We optimized and characterized fibrous scaffolds electrospun from soy protein isolate -LRB- SPI -RRB- with addition of 0.05 % poly -LRB- ethylene_oxide -RRB- -LRB- PEO -RRB- dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol , and from corn zein dissolved in glacial acetic_acid . 22839659 1 1,1,1,3,3,3-hexafluoro-2-propanol 175,208 SPI 123,126 1,1,1,3,3,3-hexafluoro-2-propanol SPI MESH:C001337 1113 Chemical Gene dissolved|nmod|START_ENTITY dissolved|nsubjpass|isolate isolate|appos|END_ENTITY Soy protein isolate -LRB- SPI -RRB- and polyethylene_oxide -LRB- PEO -RRB- were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- and nonwoven nanofiber membranes were prepared from the solution by electrospinning . 8915611 4 1,1,1,3,3,3-Hexafluoro-2-propanol 410,443 PrP 532,535 1,1,1,3,3,3-Hexafluoro-2-propanol PrP MESH:C001337 5621 Chemical Gene modified|nsubj|START_ENTITY modified|dobj|ultrastructure ultrastructure|nmod|amyloids amyloids|compound|END_ENTITY 1,1,1,3,3,3-Hexafluoro-2-propanol -LRB- HFIP -RRB- , which promotes alpha-helix formation , modified the ultrastructure of rod-shaped PrP amyloids , producing flattened ribbons with a more regular substructure . 20832306 1 1,1,1,3,3,3-hexafluoro-2-propanols 161,195 malonyl-CoA_decarboxylase 227,252 1,1,1,3,3,3-hexafluoro-2-propanols malonyl-CoA decarboxylase null 56690(Tax:10090) Chemical Gene series|nmod|START_ENTITY prepared|nsubjpass|series prepared|nmod|inhibitors inhibitors|amod|END_ENTITY A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA_decarboxylase -LRB- MCD -RRB- inhibitors . 2356122 2 1,1,1,3,3,3-hexafluoro-2-propoxide 353,387 PCl3 393,397 1,1,1,3,3,3-hexafluoro-2-propoxide PCl3 null 26147 Chemical Gene salt|nmod|START_ENTITY reaction|nmod|salt prepared|nmod|reaction prepared|nmod|END_ENTITY Tris -LRB- 1,1,1,3,3,3-hexafluoro-2-propyl -RRB- _ phosphite , prepared by the reaction of lithium salt of 1,1,1,3,3,3-hexafluoro-2-propoxide with PCl3 , reacts with deoxyribonucleosides in the presence of a catalytic amount of triethylamine to produce in the high yield the corresponding deoxyribonucleoside_3 ' - H-phosphonate units . 28325748 7 1,1,1,3,3,3-hexafluoropropanol 1380,1410 TASK-3 1437,1443 1,1,1,3,3,3-hexafluoropropanol TASK-3 null 51305 Chemical Gene carbon_tetrabromide|conj|START_ENTITY activate|nsubj|carbon_tetrabromide activate|xcomp|END_ENTITY Similarly , carbon_tetrabromide -LRB- 296 % -LSB- 245-346 -RSB- -RRB- , carbon_tetrachloride -LRB- 180 % -LSB- 163-196 -RSB- -RRB- , and 1,1,1,3,3,3-hexafluoropropanol -LRB- 200 % -LSB- 194-206 -RSB- -RRB- activate TASK-3 , whereas the larger carbon_tetraiodide and a-chloralose inhibit . 18616310 3 1,1,1,3,3,3-hexamethyldisilazane 514,546 TMS-A 579,584 1,1,1,3,3,3-hexamethyldisilazane TMS-A null 7168 Chemical Gene HMDS|amod|START_ENTITY HMDS|appos|allyltrimethylsilane allyltrimethylsilane|appos|END_ENTITY Among the silanizing agents used in this study were 1,1,1,3,3,3-hexamethyldisilazane -LRB- HMDS -RRB- , allyltrimethylsilane -LRB- TMS-A -RRB- , chlorotrimethylsilane -LRB- TMS-Cl -RRB- , N - -LRB- trimethylsilyl -RRB- imidazole -LRB- TMS-Im -RRB- , and N , _ N-dimethylaminotrimethylsilane -LRB- TMS-DMA -RRB- . 14518910 1 1,1,1,3,3-pentafluoropropane 302,330 CBF2 284,288 1,1,1,3,3-pentafluoropropane CBF2 MESH:C403631 10153 Chemical Gene XeF2|nmod|START_ENTITY triple_bond|nmod|XeF2 triple_bond|dobj|END_ENTITY The salt -LSB- CF3C -LSB- triple_bond -RSB- CXe -RSB- -LSB- BF4 -RSB- was prepared as neat compound by the reaction of the hitherto unknown alkynyldifluoroborane CF3C -LSB- triple_bond -RSB- CBF2 with XeF2 in 1,1,1,3,3-pentafluoropropane -LRB- PFP -RRB- at -45 degrees C in 59 % yield . 24014441 6 11-13_amino_acid 814,830 ObR 861,864 11-13 amino acid ObR null 3953 Chemical Gene receptor|amod|START_ENTITY receptor|appos|END_ENTITY A family of 11-13_amino_acid residue-long leptin receptor -LRB- ObR -RRB- agonists has been identified by analyzing the effect of peptides corresponding to the three presumed active sites of leptin on the growth of leptin-responsive cancer cells . 9756624 2 1113-amino-acid 297,312 LRP4 277,281 1113-amino-acid LRP4 null 228357(Tax:10090) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY Murine LRP4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters . 27806737 7 11,13-dihydroderivative 1046,1069 C-11 1103,1107 11,13-dihydroderivative C-11 null 51728 Chemical Gene START_ENTITY|dep|2H-DhL 2H-DhL|dep|mixture mixture|nmod|epimers epimers|nmod|END_ENTITY It has been also shown that DhL and its 11,13-dihydroderivative -LRB- 2H-DhL ; a mixture of epimers at C-11 -RRB- act as blockers of the resumption of meiosis in fully grown ovarian oocytes from the amphibian Rhinella arenarum -LRB- formerly classified as Bufo arenarum -RRB- . 17705600 3 1,1,1,3-fluoroacetone 463,484 CO2 504,507 1,1,1,3-fluoroacetone CO2 null 717 Chemical Gene START_ENTITY|conj|END_ENTITY A second series of experiments using 1,1,1,3-fluoroacetone , acetonitrile , and CO2 as ligands failed to show any evidence of photofragmentation . 25030319 7 11-14_amino_acids 889,906 TF 970,972 11-14 amino acids TF null 14066(Tax:10090) Chemical Gene length|nmod|START_ENTITY Peptides|nmod|length inhibited|nsubj|Peptides inhibited|conj|affect affect|dobj|activity activity|compound|END_ENTITY Peptides 5 , 6 , 7 , 21 and 22 , at the length of 11-14_amino_acids , inhibited heparanase procoagulant activity but did not affect TF activity . 10984110 10 11,14-eicosadienoate 1656,1676 delta8_and_delta5_desaturases 1783,1812 11,14-eicosadienoate delta8 and delta5 desaturases null 84575(Tax:10116) Chemical Gene fed|nsubjpass|START_ENTITY labeled|ccomp|fed arachidonate|advcl|labeled greater|advcl|arachidonate suggests|advmod|greater suggests|ccomp|metabolized metabolized|nmod|use use|nmod|END_ENTITY However , the presence of an ion , six mass units greater than endogenous arachidonate when doubly labeled 11,14-eicosadienoate was fed , suggests that a small amount of the substrate may have been metabolized by the sequential use of delta8_and_delta5_desaturases . 19243996 10 1114G 1465,1470 RGS2 1481,1485 1114G RGS2 null 5997 Chemical Gene allele|nummod|START_ENTITY allele|nmod|END_ENTITY Neither the 393T allele of GNAS1 and 825T allele of GNB3 nor 1114G allele of RGS2 was associated with enhanced risk of severe clinical manifestation -LRB- P > 0.05 -RRB- . 14552638 7 1,1,1,5,5,5-hexafluoroacetylacetonate 639,676 L1 605,607 1,1,1,5,5,5-hexafluoroacetylacetonate L1 null 51571 Chemical Gene Reactions|dep|START_ENTITY Reactions|nmod|END_ENTITY Reactions of L1 and L2 with M -LRB- hfac -RRB- -LRB- 2 -RRB- -LRB- hfac = 1,1,1,5,5,5-hexafluoroacetylacetonate , M = Mn , Ni , Cu , Zn -RRB- produce 2:1 complexes -LRB- L -RRB- -LRB- 2 -RRB- . 9199286 2 1,116-amino-acid 308,324 mkh1 258,262 1,116-amino-acid mkh1 MESH:C477353 854130(Tax:4932) Chemical Gene protein|amod|START_ENTITY encoding|dobj|protein exon|acl|encoding contained|nmod|exon contained|nsubjpass|region region|nmod|END_ENTITY The coding region of mkh1 is contained within a single exon encoding a 1,116-amino-acid protein . 20457951 3 11-16_nucleotides 829,846 APOE 651,655 11-16 nucleotides APOE MESH:D009711 348 Chemical Gene alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|linked linked|nmod|APOE3 APOE3|dep|encoding encoding|dobj|isoform isoform|nmod|END_ENTITY When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset . 20457951 3 11-16_nucleotides 829,846 APOE3 611,616 11-16 nucleotides APOE3 MESH:D009711 348 Chemical Gene alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|linked linked|nmod|END_ENTITY When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset . 20457951 3 11-16_nucleotides 829,846 TOMM40 669,675 11-16 nucleotides TOMM40 MESH:D009711 10452 Chemical Gene alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|repeats repeats|nummod|END_ENTITY When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset . 20457951 3 11-16_nucleotides 829,846 TOMM40 809,815 11-16 nucleotides TOMM40 MESH:D009711 10452 Chemical Gene alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|nmod|age age|nmod|onset onset|conj|END_ENTITY When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset . 25957974 1 11,17-dioxoandrostane 249,270 haptoglobin 304,315 11,17-dioxoandrostane haptoglobin null 280692(Tax:9913) Chemical Gene concentrations|dep|START_ENTITY concentrations|appos|cortisol cortisol|conj|END_ENTITY UNASSIGNED : The objective was to evaluate the association of peripartum concentrations of fecal cortisol metabolites -LRB- 11,17-dioxoandrostane ; 11,17-DOA -RRB- , plasma cortisol and haptoglobin -LRB- Hp -RRB- , as well as two markers of negative energy balance , non-esterified fatty_acid -LRB- NEFA -RRB- and postpartum_b-hydroxybutyrate -LRB- BHBA -RRB- , with milk yield and reproductive performance . 25957974 1 11,17-DOA 272,281 haptoglobin 304,315 11,17-DOA haptoglobin null 280692(Tax:9913) Chemical Gene 11,17-dioxoandrostane|dep|START_ENTITY concentrations|dep|11,17-dioxoandrostane concentrations|appos|cortisol cortisol|conj|END_ENTITY UNASSIGNED : The objective was to evaluate the association of peripartum concentrations of fecal cortisol metabolites -LRB- 11,17-dioxoandrostane ; 11,17-DOA -RRB- , plasma cortisol and haptoglobin -LRB- Hp -RRB- , as well as two markers of negative energy balance , non-esterified fatty_acid -LRB- NEFA -RRB- and postpartum_b-hydroxybutyrate -LRB- BHBA -RRB- , with milk yield and reproductive performance . 18001136 7 11,19-oxidoprogesterone 1116,1139 FKBP52 1093,1099 11,19-oxidoprogesterone FKBP52 MESH:C092753 2288 Chemical Gene recruited|nmod|START_ENTITY recruited|dobj|amounts amounts|nmod|END_ENTITY Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 . 18001136 7 11,19-oxidoprogesterone 1170,1193 FKBP52 1093,1099 11,19-oxidoprogesterone FKBP52 MESH:C092753 2288 Chemical Gene binding|amod|START_ENTITY favored|nsubj|binding favored|parataxis|recruited recruited|dobj|amounts amounts|nmod|END_ENTITY Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 . 11909639 0 11,19-oxidoprogesterone 218,241 mineralocorticoid_receptor 48,74 11,19-oxidoprogesterone mineralocorticoid receptor MESH:C092753 4306 Chemical Gene antagonists|conj|START_ENTITY binding|nmod|antagonists evidences|nmod|binding evidences|nsubj|Modification Modification|nmod|group group|nmod|END_ENTITY Modification of an essential amino group in the mineralocorticoid_receptor evidences a differential conformational change of the receptor protein upon binding of antagonists , natural agonists and the synthetic agonist 11,19-oxidoprogesterone . 10860927 3 11,19-oxidoprogesterone 461,484 MR 493,495 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene START_ENTITY|nmod|END_ENTITY Despite its biological potency , the relative affinity of 11,19-oxidoprogesterone for the MR is 5-fold lower than that of 21-deoxycorticosterone and 10-fold lower than aldosterone . 10860927 6 11,19-oxidoprogesterone 885,908 MR 958,960 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene START_ENTITY|conj|ability ability|acl|transform transform|dobj|END_ENTITY We show that both the pharmacokinetic properties of 11,19-oxidoprogesterone and its ability to transform and translocate the MR into the nucleus are undistinguishable from aldosterone . 10860927 8 11,19-oxidoprogesterone 1479,1502 MR 1519,1521 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene bind|nsubj|START_ENTITY bind|nmod|END_ENTITY In addition , the binding properties of both steroids are differentially affected by modification of crucial lysyl residues of the MR. Kinetic studies performed on the aldosterone-MR complex in the presence of low concentrations of oxidopregnane suggest that 11,19-oxidoprogesterone may bind to the MR in a different binding site from the aldosterone binding pocket . 11909639 6 11,19-oxidoprogesterone 1119,1142 MR 1074,1076 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene shows|nsubj|START_ENTITY shows|parataxis|END_ENTITY Like the antagonistic ligands , and despite its potent mineralocorticoid biological effect , the sole MR specific synthetic agonist known to date , 11,19-oxidoprogesterone -LRB- 11-OP -RRB- , shows no protective effect upon treatment of the MR with pyridoxal_5 ' - phosphate or TNBS . 11909639 6 11,19-oxidoprogesterone 1119,1142 MR 1201,1203 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene shows|nsubj|START_ENTITY shows|nmod|treatment treatment|nmod|END_ENTITY Like the antagonistic ligands , and despite its potent mineralocorticoid biological effect , the sole MR specific synthetic agonist known to date , 11,19-oxidoprogesterone -LRB- 11-OP -RRB- , shows no protective effect upon treatment of the MR with pyridoxal_5 ' - phosphate or TNBS . 18001136 5 11,19-oxidoprogesterone 859,882 MR 834,836 11,19-oxidoprogesterone MR MESH:C092753 4306 Chemical Gene used|nsubjpass|START_ENTITY used|advcl|elucidate elucidate|dobj|mechanism mechanism|nmod|action action|nmod|END_ENTITY To elucidate the mechanism of action of MR , the synthetic ligand 11,19-oxidoprogesterone was used as a tool . 18001136 7 11,19-oxidoprogesterone 1116,1139 PP5 1277,1280 11,19-oxidoprogesterone PP5 MESH:C092753 5536 Chemical Gene recruited|nmod|START_ENTITY favored|parataxis|recruited favored|dobj|recruitment recruitment|nmod|END_ENTITY Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 . 18001136 7 11,19-oxidoprogesterone 1170,1193 PP5 1277,1280 11,19-oxidoprogesterone PP5 MESH:C092753 5536 Chemical Gene binding|amod|START_ENTITY favored|nsubj|binding favored|dobj|recruitment recruitment|nmod|END_ENTITY Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 . 8982344 4 1,11-acyl 185,194 ACAT 312,316 1,11-acyl ACAT null 6646 Chemical Gene groups|amod|START_ENTITY Replacement|nmod|groups Replacement|dep|cholesterol_acyltransferase cholesterol_acyltransferase|appos|END_ENTITY Replacement of the 1,11-acyl groups of pyripyropenes with 1,11-cyclic _ acetals effectively improved in vitro acyl_CoA : cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitory activity . 9065427 2 111-amino_acid_polypeptide 281,307 beta3 379,384 111-amino acid polypeptide beta3 null 1934 Chemical Gene START_ENTITY|acl:relcl|interacts interacts|nmod|domain domain|amod|END_ENTITY Recently , we identified a novel 111-amino_acid_polypeptide , termed beta3-endonexin , which interacts selectively with the integrin beta3 cytoplasmic domain . 9065427 2 111-amino_acid_polypeptide 281,307 beta3-endonexin 316,331 111-amino acid polypeptide beta3-endonexin null 23421 Chemical Gene START_ENTITY|acl|termed termed|xcomp|END_ENTITY Recently , we identified a novel 111-amino_acid_polypeptide , termed beta3-endonexin , which interacts selectively with the integrin beta3 cytoplasmic domain . 15536220 1 1_11beta-hydroxysteroid 112,135 11beta-HSD1 151,162 1 11beta-hydroxysteroid 11beta-HSD1 null 3290;26871 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY Adipose tissue type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- , which generates hormonally active cortisol from inactive cortisone , has been shown to play a central role in adipocyte differentiation and abdominal_obesity-related_metabolic_complications . 15542590 3 1_11beta-hydroxysteroid 635,658 11beta-HSD1 674,685 1 11beta-hydroxysteroid 11beta-HSD1 null 100135542(Tax:10141) Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY This reaction is carried out by the NADPH-dependent type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- , an enzyme attached through an integral N-terminal transmembrane helix to the lipid bilayer and located with its active site within the lumen of the endoplasmic reticulum . 16431016 1 1_11beta-hydroxysteroid 166,189 11beta-HSD1 205,216 1 11beta-hydroxysteroid 11beta-HSD1 null 3290;26871 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY The NADPH-dependent enzyme type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- activates in a tissue-specific manner circulating pro-glucocorticoid hormones -LRB- cortisone in humans -RRB- to the 11beta-OH ligand -LRB- cortisol in humans -RRB- , which is able to bind to its cognate receptor and regulate gene transcription . 17470521 1 1_11beta-hydroxysteroid 250,273 11betaHSD2 361,371 1 11beta-hydroxysteroid 11betaHSD2 null 282434(Tax:9913) Chemical Gene enzyme|amod|START_ENTITY NADP|conj|enzyme catalysed|nmod|NADP catalysed|dep|END_ENTITY Cortisol-cortisone metabolism is catalysed by the bi-directional NADP -LRB- H -RRB- - dependent type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11betaHSD1 -RRB- enzyme and the oxidative NAD -LRB- + -RRB- - dependent type 2 11betaHSD -LRB- 11betaHSD2 -RRB- . 7574456 2 1-11C-D-glucose 395,410 dl-1 503,507 1-11C-D-glucose dl-1 null 28514 Chemical Gene concentrations|amod|START_ENTITY concentrations|nmod|ml-1 ml-1|appos|END_ENTITY We performed eight positron emission tomography studies with 1-11C-D-glucose in macaques at arterial plasma glucose concentrations of 8.43 to 1.51 mumol ml-1 -LRB- 152-27 mg dl-1 -RRB- using a model that includes a fourth rate constant to account for regional egress of all 11C-metabolites . 15585478 0 1-11C-methyl-4-piperidinyl_n-butyrate 40,77 butyrylcholinesterase 132,153 1-11C-methyl-4-piperidinyl n-butyrate butyrylcholinesterase MESH:C420915 590 Chemical Gene metabolism|nmod|START_ENTITY metabolism|dep|agent agent|nmod|assessment assessment|nmod|activity activity|amod|END_ENTITY Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl_n-butyrate in humans : an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET . 26703223 2 1-11E 388,393 scFv 435,439 1-11E scFv null 652070 Chemical Gene START_ENTITY|appos|variable variable|appos|END_ENTITY We previously showed that 1-11E , a human single chain fragment variable -LRB- scFv -RRB- specific to collagen type II that has been post-translationally modified by reactive oxidants -LRB- ROS-CII -RRB- , binds exclusively to arthritic cartilage . 8390165 0 111In 1,6 alpha-MSH 33,42 111In alpha-MSH null 5443 Chemical Gene -RSB-|nsubj|START_ENTITY -RSB-|dobj|analogues analogues|nmod|END_ENTITY -LSB- 111In -RSB- DTPA-labeled analogues of alpha-MSH for the detection of MSH receptors in vitro and in vivo . 21253675 0 111In 163,168 EGFR 198,202 111In EGFR null 1956 Chemical Gene -RSB-|amod|START_ENTITY processing|nmod|-RSB- comparison|nmod|processing receptors|dep|comparison agents|dep|receptors labeled|nsubj|agents labeled|dobj|Z Z|appos|END_ENTITY Imaging agents for in vivo molecular profiling of disseminated prostate_cancer -- targeting EGFR receptors in prostate_cancer : comparison of cellular processing of -LSB- 111In -RSB- - labeled affibody molecule Z -LRB- EGFR :2377 -RRB- and cetuximab . 21253675 0 111In 163,168 EGFR 90,94 111In EGFR null 1956 Chemical Gene -RSB-|amod|START_ENTITY processing|nmod|-RSB- comparison|nmod|processing receptors|dep|comparison receptors|compound|END_ENTITY Imaging agents for in vivo molecular profiling of disseminated prostate_cancer -- targeting EGFR receptors in prostate_cancer : comparison of cellular processing of -LSB- 111In -RSB- - labeled affibody molecule Z -LRB- EGFR :2377 -RRB- and cetuximab . 9153559 6 111In 1170,1175 E-selectin 1336,1346 111In E-selectin null 6401 Chemical Gene indium|appos|START_ENTITY cells|conj|indium 99mTc|dep|cells labeled|nsubj|99mTc labeled|advcl|quantify quantify|dobj|recruitment recruitment|conj|expression expression|amod|END_ENTITY 99mtechnetium -LRB- 99mTc -RRB- - labeled PMN cells and -LRB- 111 -RRB- indium -LRB- 111In -RRB- - labeled anti-E-selectin monoclonal antibody -LRB- MAb -RRB- 1.2 B6 were intravenously administered 4 hours after intraarticular injection to quantify PMN recruitment and E-selectin expression in inflamed joints . 2133278 2 111In 503,508 GM-CSF 588,594 111In GM-CSF null 12981(Tax:10090) Chemical Gene -RSB-|amod|START_ENTITY -RSB-|dep|labeled labeled|conj|used used|dobj|model model|acl|study study|dobj|influence influence|nmod|END_ENTITY We developed a murine model to determine the biodistribution kinetics of -LSB- 111In -RSB- labeled neutrophils and used this model to study the influence of recombinant GM-CSF on neutrophil influx into inflammatory sites . 8390165 0 111In 1,6 MSH 64,67 111In MSH null 5443 Chemical Gene -RSB-|nsubj|START_ENTITY -RSB-|nmod|detection detection|nmod|receptors receptors|compound|END_ENTITY -LSB- 111In -RSB- DTPA-labeled analogues of alpha-MSH for the detection of MSH receptors in vitro and in vivo . 15305020 2 111In 415,420 transferrin 463,474 111In transferrin null 24825(Tax:10116) Chemical Gene entering|nmod|START_ENTITY entering|nmod|affinity affinity|acl|END_ENTITY In the present study , we investigated whether the entering of indium-111 -LRB- 111In -RRB- and iron-59 _ -LRB- 59Fe -RRB- with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy . 1751138 2 111In 270,275 VWF 157,160 111In VWF null 7450 Chemical Gene platelets|amod|START_ENTITY donors|nmod:poss|platelets exposing|nmod|donors examined|advcl|exposing examined|nsubjpass|role role|nmod|factor factor|appos|END_ENTITY The role of von_Willebrand 's _ factor -LRB- VWF -RRB- was examined in platelet deposition on polyethylene by exposing 3/16 inch diameter discs of polyethylene to 111In labeled platelets re-suspended in citrated blood from normal and severe von_Willebrand 's disease donors . 1330982 4 111In-2G3 794,803 transferrin 764,775 111In-2G3 transferrin null 7018 Chemical Gene stability|nmod|START_ENTITY differ|nsubj|stability differ|nmod|basis basis|nmod|measurement measurement|nmod|transchelation transchelation|nmod|END_ENTITY On the basis of measurement of transchelation to transferrin , the stability of 111In-2G3 prepared using DTPA_anhydride or benzyl_DTPA did not differ during incubation in human plasma for 6 days at 37 degrees C . 24665085 0 111In-ABY-025 90,103 HER2 36,40 111In-ABY-025 HER2 null 2064 Chemical Gene molecule|amod|START_ENTITY using|dobj|molecule metastases|xcomp|using metastases|nsubj|imaging imaging|nmod|expression expression|nummod|END_ENTITY First-in-human molecular imaging of HER2 expression in breast_cancer metastases using the 111In-ABY-025 affibody molecule . 1692949 1 111In-BLMC 129,139 SCLC 267,271 111In-BLMC SCLC null 7864 Chemical Gene complex|dep|START_ENTITY agent|nsubj|complex agent|acl:relcl|produces produces|conj|kills kills|dobj|cells cells|appos|END_ENTITY Indium-111-bleomycin complex -LRB- 111In-BLMC -RRB- is a radiopharmaceutical agent that produces tumor regression in mouse glioma in vivo and kills human small_cell_lung_cancer -LRB- SCLC -RRB- cells in vitro . 6498219 6 111In-Ca-DTPA 2073,2086 IgG1 2123,2127 111In-Ca-DTPA IgG1 null 16017(Tax:10090) Chemical Gene carboxyfluorescein|conj|START_ENTITY devoid|amod|carboxyfluorescein devoid|nmod|END_ENTITY AKR mice were injected intravenously with 99mTc-labelled AKR-A cells and 2.5 min later with anti-Thy1 125I-IgG1-bearing liposomes containing quenched carboxyfluorescein and 111In-Ca-DTPA or with similar liposomes devoid of IgG1 . 18034550 0 111In-capromab_pendetide 0,24 prostate_specific_membrane_antigen 43,77 111In-capromab pendetide prostate specific membrane antigen null 2346 Chemical Gene START_ENTITY|dep|evolution evolution|nmod|END_ENTITY 111In-capromab_pendetide : the evolution of prostate_specific_membrane_antigen and the nuclear imaging of its 111In-labelled murine antibody in the evaluation of prostate_cancer . 22284727 4 111InCl3 639,647 anti-carbonic_anhydrase_IX 835,861 111InCl3 anti-carbonic anhydrase IX null 768 Chemical Gene amounts|nmod|START_ENTITY added|nsubjpass|amounts added|nmod|g g|nmod|-LSB- -LSB-|acl:relcl|tetraacetic_acid tetraacetic_acid|dobj|-RSB- -RSB-|dep|compounds compounds|dep|antibody antibody|compound|octreotide octreotide|conj|END_ENTITY METHODS : Escalating amounts of 111InCl3 were added to 1 g of the diethylene_triamine_pentaacetic_acid -LSB- DTPA -RSB- - and 1,4,7,10-tetraazacyclododecane-1 ,4,7,10 - tetraacetic_acid -LSB- DOTA -RSB- - conjugated compounds -LRB- exendin-3 , octreotide and anti-carbonic_anhydrase_IX -LSB- CAIX -RSB- antibody -RRB- . 22284727 4 111InCl3 639,647 CAIX 863,867 111InCl3 CAIX null 768 Chemical Gene amounts|nmod|START_ENTITY added|nsubjpass|amounts added|nmod|g g|nmod|-LSB- -LSB-|acl:relcl|tetraacetic_acid tetraacetic_acid|dobj|-RSB- -RSB-|dep|compounds compounds|dep|antibody antibody|compound|END_ENTITY METHODS : Escalating amounts of 111InCl3 were added to 1 g of the diethylene_triamine_pentaacetic_acid -LSB- DTPA -RSB- - and 1,4,7,10-tetraazacyclododecane-1 ,4,7,10 - tetraacetic_acid -LSB- DOTA -RSB- - conjugated compounds -LRB- exendin-3 , octreotide and anti-carbonic_anhydrase_IX -LSB- CAIX -RSB- antibody -RRB- . 16710024 4 111In-diethylenetriamine_penta-acetic_acid_anhydride 738,790 epidermal_growth_factor_receptor_2 577,611 111In-diethylenetriamine penta-acetic acid anhydride epidermal growth factor receptor 2 null 2064 Chemical Gene MBq|amod|START_ENTITY injection|nmod|MBq underwent|nmod|injection underwent|nsubj|Patients Patients|nmod|END_ENTITY PATIENTS AND METHODS : Patients with human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- - positive metastatic breast_cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In-diethylenetriamine_penta-acetic_acid_anhydride -LRB- DTPA -RRB- - trastuzumab , after loading-dose trastuzumab , and after once-a-week trastuzumab doses for 11 weeks , and concomitant paclitaxel once every 3 weeks . 16710024 4 111In-diethylenetriamine_penta-acetic_acid_anhydride 738,790 HER2 613,617 111In-diethylenetriamine penta-acetic acid anhydride HER2 null 2064 Chemical Gene MBq|amod|START_ENTITY injection|nmod|MBq underwent|nmod|injection underwent|nsubj|Patients Patients|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|appos|END_ENTITY PATIENTS AND METHODS : Patients with human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- - positive metastatic breast_cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In-diethylenetriamine_penta-acetic_acid_anhydride -LRB- DTPA -RRB- - trastuzumab , after loading-dose trastuzumab , and after once-a-week trastuzumab doses for 11 weeks , and concomitant paclitaxel once every 3 weeks . 3657182 1 111-indium 363,373 anti-carcinoembryonic_antigen 285,314 111-indium anti-carcinoembryonic antigen MESH:C020758 1084 Chemical Gene mCi|nmod|START_ENTITY labeled|nmod|mCi micrograms|acl|labeled micrograms|nmod|antibody antibody|amod|END_ENTITY Patients with primary and/or metastatic colorectal_cancer who had been scheduled for operative intervention were injected intravenously with 200 micrograms of a high-affinity anti-carcinoembryonic_antigen -LRB- CEA -RRB- monoclonal antibody labeled with 2 mCi of 111-indium -LRB- Indacea -RRB- . 3657182 1 111-indium 363,373 CEA 316,319 111-indium CEA MESH:C020758 1084 Chemical Gene mCi|nmod|START_ENTITY labeled|nmod|mCi micrograms|acl|labeled micrograms|nmod|antibody antibody|appos|END_ENTITY Patients with primary and/or metastatic colorectal_cancer who had been scheduled for operative intervention were injected intravenously with 200 micrograms of a high-affinity anti-carcinoembryonic_antigen -LRB- CEA -RRB- monoclonal antibody labeled with 2 mCi of 111-indium -LRB- Indacea -RRB- . 12094949 1 111-indium 232,242 cytokeratin_19 286,300 111-indium cytokeratin 19 MESH:C020758 16669(Tax:10090) Chemical Gene labeling|dobj|START_ENTITY labeling|nmod|antibody antibody|nmod|END_ENTITY PURPOSE : To establish a radioimmunodetection -LRB- RAID -RRB- system for localization of cervical_cancer by labeling 111-indium -LRB- -LRB- 111 -RRB- In -RRB- to a monoclonal antibody against cytokeratin_19 -LRB- MAb Cx-99 -RRB- , and detecting it with a hand-held gamma detector in an animal model . 3349123 2 111Indium 560,569 AT_III 460,466 111Indium AT III null 462 Chemical Gene labelled|nmod|START_ENTITY antibody|acl|labelled END_ENTITY|conj|antibody This paper describes an isotopic method to estimate this density and to visualize the distribution of the affinity sites concerned , both directly with AT_III labelled with 125Iodine and indirectly with an anti AT_III monoclonal antibody labelled with 111Indium . 3349123 2 111Indium 560,569 AT_III 519,525 111Indium AT III null 462 Chemical Gene labelled|nmod|START_ENTITY antibody|acl|labelled antibody|compound|END_ENTITY This paper describes an isotopic method to estimate this density and to visualize the distribution of the affinity sites concerned , both directly with AT_III labelled with 125Iodine and indirectly with an anti AT_III monoclonal antibody labelled with 111Indium . 10615242 1 111Indium 134,143 GA17 206,210 111Indium GA17 null 10480 Chemical Gene 111In|amod|START_ENTITY 111In|acl|labelled labelled|xcomp|internalising internalising|dobj|END_ENTITY The potential of 111Indium -LRB- 111In -RRB- - labelled internalising anti-integrin_alpha_3 antibody GA17 in the radioimmunotherapy of human glioblastoma xenografts in nude_mice was investigated . 3682767 4 111Indium 589,598 lactate_dehydrogenase 556,577 111Indium lactate dehydrogenase null 101409728 Chemical Gene 51Chromium|conj|START_ENTITY 51Chromium|conj|END_ENTITY We compared the loss of 51Chromium -LRB- 51Cr -RRB- , the cytoplasmic enzyme lactate_dehydrogenase -LRB- LDH -RRB- , and 111Indium -LRB- 111In -RRB- from endothelial cells upon exposure to several injurious agents . 3682767 4 111Indium 589,598 LDH 579,582 111Indium LDH null 101409728 Chemical Gene 51Chromium|conj|START_ENTITY 51Chromium|conj|lactate_dehydrogenase lactate_dehydrogenase|appos|END_ENTITY We compared the loss of 51Chromium -LRB- 51Cr -RRB- , the cytoplasmic enzyme lactate_dehydrogenase -LRB- LDH -RRB- , and 111Indium -LRB- 111In -RRB- from endothelial cells upon exposure to several injurious agents . 12472080 9 111Indium 1575,1584 somatostatin 1623,1635 111Indium somatostatin MESH:C020758 6750 Chemical Gene based|nmod|START_ENTITY based|advcl|analogues analogues|compound|END_ENTITY Radioligand therapy based on 111Indium , 90Yttrium and 177Lutetium coupled to somatostatin analogues via bifunctional chelators is currently under investigation with promising data concerning long-lasting control of symptoms and tumour_growth from Phase I trials . 4077977 6 111Indium 911,920 thrombin 877,885 111Indium thrombin null 2147 Chemical Gene adding|dobj|START_ENTITY washed|advcl|adding treated|conj|washed treated|nmod|END_ENTITY Furthermore , enhanced neutrophil adherence occurred when endothelial monolayers were treated with thrombin and washed before adding 111Indium -LRB- 111In -RRB- - labeled PMNs . 10799151 14 111Indium_capromab_pendetide 2134,2162 PSA 2232,2235 111Indium capromab pendetide PSA MESH:C063430 354 Chemical Gene scan|amod|START_ENTITY scan|acl:relcl|approved approved|nmod|recurrence recurrence|compound|END_ENTITY 111Indium_capromab_pendetide radionuclide scan , which has been approved for radical prostatectomy PSA only recurrence , may be helpful to determine cases best suited for salvage radiotherapy versus systemic hormonal therapy , although more study is needed . 1944906 0 111indium-DTPA 27,41 CSF 42,45 111indium-DTPA CSF MESH:C103803 1437 Chemical Gene studies|amod|START_ENTITY studies|compound|END_ENTITY Leptomeningeal_metastases : 111indium-DTPA CSF flow studies . 1944906 1 111indium-DTPA 176,190 CSF 196,199 111indium-DTPA CSF MESH:C103803 1437 Chemical Gene studies|amod|START_ENTITY studies|compound|END_ENTITY Thirty consecutive patients with cytologically documented leptomeningeal_metastases -LRB- LM -RRB- underwent intraventricular 111indium-DTPA -LRB- In -RRB- CSF flow studies -LRB- FS -RRB- . 6237710 2 111indium-DTPA 553,567 M8 413,415 111indium-DTPA M8 MESH:C103803 149830 Chemical Gene conjugate|amod|START_ENTITY using|dobj|conjugate recorded|xcomp|using found|conj|recorded found|nmod|degree degree|nmod|localization localization|nmod|END_ENTITY No significant difference was found in the degree of localization of radio-iodinated M8 in subcutaneous , renal or intracranial xenografts , but a highly significant improvement in HX99 localization by M8 was recorded using an 111indium-DTPA conjugate of the antibody -LRB- 111In-DTPA-M8 -RRB- , related to its rapid tumour uptake and blood pool clearance . 6388012 1 111Indium_oxine 80,95 beta_TG 188,195 111Indium oxine beta TG null 5473 Chemical Gene studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|END_ENTITY Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg . 6388012 1 111Indium_oxine 80,95 beta-thromboglobulin 166,186 111Indium oxine beta-thromboglobulin null 5473 Chemical Gene studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|beta_TG beta_TG|amod|END_ENTITY Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg . 25330503 7 111Indium_oxine 957,972 hTEC 919,923 111Indium oxine hTEC null 7006 Chemical Gene using|dobj|START_ENTITY studied|xcomp|using studied|nsubjpass|biodistribution biodistribution|nmod|END_ENTITY The biodistribution and fate of hTEC were studied using radiolabelled 111Indium_oxine and fluorescent in situ hybridisation . 6388012 1 111Indium_oxine 80,95 PF4 220,223 111Indium oxine PF4 null 5196 Chemical Gene studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|platelet_factor_4 platelet_factor_4|appos|END_ENTITY Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg . 6388012 1 111Indium_oxine 80,95 platelet_factor_4 201,218 111Indium oxine platelet factor 4 null 5196 Chemical Gene studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|END_ENTITY Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg . 8504205 3 111Indium-oxine 549,564 interleukin-2 517,530 111Indium-oxine interleukin-2 MESH:C032950 3558 Chemical Gene labeled|advcl|START_ENTITY labeled|nsubjpass|lymphocytes lymphocytes|acl|isolated isolated|nmod|malignant_metastatic_breast_cancer malignant_metastatic_breast_cancer|acl|cultured cultured|advcl|vitro vitro|nmod|low-dose low-dose|nmod|END_ENTITY Tumor-infiltrating lymphocytes isolated from five patients with malignant_metastatic_breast_cancer or melanoma cultured and expanded in vitro with low-dose of recombinant interleukin-2 were labeled with 111Indium-oxine and infused to the patients . 18481386 9 111Indium-oxine 1252,1267 mDC 1322,1325 111Indium-oxine mDC null 20299(Tax:10090) Chemical Gene gave|nsubj|START_ENTITY gave|dobj|tracking tracking|nmod|nmDc nmDc|conj|END_ENTITY 111Indium-oxine , however , gave reproducible tracking of both nmDc and mDC -LRB- n = 6 -RRB- to regional lymph node after either SC or ID administration , with mDC revealing superior migration to regional lymph node . 18481386 9 111Indium-oxine 1252,1267 mDC 1398,1401 111Indium-oxine mDC null 20299(Tax:10090) Chemical Gene gave|nsubj|START_ENTITY gave|nmod|END_ENTITY 111Indium-oxine , however , gave reproducible tracking of both nmDc and mDC -LRB- n = 6 -RRB- to regional lymph node after either SC or ID administration , with mDC revealing superior migration to regional lymph node . 20542702 2 111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic_acid-cholecystokinin_octapeptide 664,753 CCK2R 515,520 111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic acid-cholecystokinin octapeptide CCK2R null 887 Chemical Gene visualization|amod|START_ENTITY END_ENTITY|conj|visualization To our knowledge this is the first CCK4-based radioligand that presents a high affinity for the CCK2R , a high and specific tumor uptake , a low_renal_accumulation and a very good visualization of tumors in vivo compared with an internal control , 111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic_acid-cholecystokinin_octapeptide -LRB- 111In-CHX-A '' - DTPA-CCK8 -RRB- . 25007399 8 111In-DOTA 1225,1235 sst2 1271,1275 111In-DOTA sst2 null 20606(Tax:10090) Chemical Gene LTT-SS28|amod|START_ENTITY mimic|dobj|LTT-SS28 mimic|dep|sst3 sst3|nmod|END_ENTITY In conclusion , the somatostatin mimic -LSB- 111In-DOTA -RSB- LTT-SS28 specifically localizes in sst2 - , sst3 - , and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging . 25007399 8 111In-DOTA 1225,1235 sst3 1278,1282 111In-DOTA sst3 null 20607(Tax:10090) Chemical Gene LTT-SS28|amod|START_ENTITY mimic|dobj|LTT-SS28 mimic|dep|END_ENTITY In conclusion , the somatostatin mimic -LSB- 111In-DOTA -RSB- LTT-SS28 specifically localizes in sst2 - , sst3 - , and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging . 19820010 3 111In-DOTA-exendin-4 481,501 GLP-1R 466,472 111In-DOTA-exendin-4 GLP-1R null 2740 Chemical Gene using|dep|START_ENTITY using|nsubj|agonist agonist|compound|END_ENTITY OBJECTIVE : The objective of the study was to test the 111In-labeled GLP-1R agonist 111In-DOTA-exendin-4 in localizing insulinomas using single photon emission computed tomography in combination with computed tomography images . 16021448 6 111In-DTPA-octreotide 1087,1108 somatostatin_receptor_subtype_2 1279,1310 111In-DTPA-octreotide somatostatin receptor subtype 2 MESH:C071632 54305(Tax:10116) Chemical Gene doses|nmod|START_ENTITY effects|nmod|doses investigated|nsubjpass|effects investigated|advcl|bearing bearing|dobj|pancreatic_CA20948_tumours pancreatic_CA20948_tumours|acl|expressing expressing|dobj|END_ENTITY METHODS : The radiotherapeutic effects of different doses of 111In-DTPA-octreotide in vivo were investigated in Lewis rats bearing small -LRB- < or = 1 cm2 -RRB- or large -LRB- > or = 8 cm2 -RRB- somatostatin receptor-positive rat pancreatic_CA20948_tumours expressing the somatostatin_receptor_subtype_2 -LRB- sst2 -RRB- . 16021448 6 111In-DTPA-octreotide 1087,1108 sst2 1312,1316 111In-DTPA-octreotide sst2 MESH:C071632 54305(Tax:10116) Chemical Gene doses|nmod|START_ENTITY effects|nmod|doses investigated|nsubjpass|effects investigated|advcl|bearing bearing|dobj|pancreatic_CA20948_tumours pancreatic_CA20948_tumours|appos|END_ENTITY METHODS : The radiotherapeutic effects of different doses of 111In-DTPA-octreotide in vivo were investigated in Lewis rats bearing small -LRB- < or = 1 cm2 -RRB- or large -LRB- > or = 8 cm2 -RRB- somatostatin receptor-positive rat pancreatic_CA20948_tumours expressing the somatostatin_receptor_subtype_2 -LRB- sst2 -RRB- . 16150802 7 111In-labeled_alphavbeta3 1000,1025 RP748 990,995 111In-labeled alphavbeta3 RP748 null 883913(Tax:272947) Chemical Gene radiotracer|amod|START_ENTITY injected|nsubjpass|radiotracer injected|advmod|END_ENTITY RP748 , an 111In-labeled_alphavbeta3 -LRB- active conformation -RRB- - targeted radiotracer was injected into groups of 5 recipients at 0 , 2 , and 4 wk after PBMC reconstitution . 6403626 6 111In-labeled_C3 1055,1071 fibrinogen 965,975 111In-labeled C3 fibrinogen null 2244 Chemical Gene precipitates|amod|START_ENTITY experiments|nmod|precipitates over-estimated|nmod|experiments over-estimated|nsubjpass|111In 111In|acl|associated associated|nmod|END_ENTITY 111In associated with fibrinogen , IgM , and haptoglobin was over-estimated in some experiments due to binding of 111In-labeled_C3 to the antigen-antibody precipitates . 6403626 6 111In-labeled_C3 1055,1071 haptoglobin 986,997 111In-labeled C3 haptoglobin null 3240 Chemical Gene precipitates|amod|START_ENTITY experiments|nmod|precipitates over-estimated|nmod|experiments over-estimated|nsubjpass|111In 111In|acl|associated associated|nmod|fibrinogen fibrinogen|conj|END_ENTITY 111In associated with fibrinogen , IgM , and haptoglobin was over-estimated in some experiments due to binding of 111In-labeled_C3 to the antigen-antibody precipitates . 24718894 2 111In-labeled_capromab_pendetide 312,344 prostate-specific_membrane_antigen 265,299 111In-labeled capromab pendetide prostate-specific membrane antigen null 2346 Chemical Gene END_ENTITY|nmod|START_ENTITY Radionuclide targeting of prostate-specific_membrane_antigen -LRB- PSMA -RRB- with 111In-labeled_capromab_pendetide -LRB- ProstaScint -RRB- is a clinical option for prostate_cancer staging . 24718894 2 111In-labeled_capromab_pendetide 312,344 PSMA 301,305 111In-labeled capromab pendetide PSMA null 2346 Chemical Gene prostate-specific_membrane_antigen|nmod|START_ENTITY prostate-specific_membrane_antigen|appos|END_ENTITY Radionuclide targeting of prostate-specific_membrane_antigen -LRB- PSMA -RRB- with 111In-labeled_capromab_pendetide -LRB- ProstaScint -RRB- is a clinical option for prostate_cancer staging . 8864137 14 111In-labeled_DC 1276,1292 IFN-gamma 1238,1247 111In-labeled DC IFN-gamma null 15978(Tax:10090) Chemical Gene using|xcomp|START_ENTITY conducted|xcomp|using conducted|nmod|END_ENTITY Biodistribution and imaging studies were conducted on IFN-gamma - and PBS-treated mice using 111In-labeled_DC . 6895481 4 111In-labeled_diethylenetriaminepentaacetic_acid 706,754 L-asparaginase 618,632 111In-labeled diethylenetriaminepentaacetic acid L-asparaginase null 80150 Chemical Gene -LSB-|advcl|START_ENTITY did|ccomp|-LSB- demonstrated|advcl|did demonstrated|nsubj|activity activity|nmod|END_ENTITY Following intrathecal injection , the enzyme activity of Escherichia_coli L-asparaginase in the CSF demonstrated a more rapid terminal half-life than did that of 111In-labeled_diethylenetriaminepentaacetic_acid , a marker of CSF bulk flow -LSB- 4 + / - 0.7 -LRB- S.D. -RRB- hr versus 5.8 + / - 0.2 hr -RSB- . 10716315 0 111In-labeled_EGF 0,17 EGFR 88,92 111In-labeled EGF EGFR null 1956 Chemical Gene radiotoxic|nsubj|START_ENTITY radiotoxic|xcomp|overexpressing overexpressing|dobj|END_ENTITY 111In-labeled_EGF is selectively radiotoxic to human breast_cancer cells overexpressing EGFR . 17015904 2 111In-labeled_phosphorothioate 283,313 N-myc 379,384 111In-labeled phosphorothioate N-myc null 4613 Chemical Gene oligonucleotides|amod|START_ENTITY emitted|nmod|oligonucleotides emitted|nmod|cells cells|acl:relcl|overexpressed overexpressed|nsubjpass|END_ENTITY We investigated the therapeutic effect of Auger electrons emitted by 111In-labeled_phosphorothioate antisense oligonucleotides on human neuroblastoma cells in which N-myc was overexpressed . 21993546 2 111In-minigastrin 418,435 GOT2 343,347 111In-minigastrin GOT2 null 14719(Tax:10090) Chemical Gene 177Lu-octreotate|conj|START_ENTITY biodistribution|nmod|177Lu-octreotate analyzing|dobj|biodistribution evaluate|advcl|analyzing evaluate|dobj|model model|compound|END_ENTITY The aim of this study was to evaluate the medullary_thyroid_carcinoma GOT2 animal model by analyzing the biodistribution of 177Lu-octreotate and 111In-minigastrin -LRB- MG0 -RRB- . 1306326 4 111In-Nd2 581,590 IgG1 715,719 111In-Nd2 IgG1 null 105243590 Chemical Gene xenograft|amod|START_ENTITY injection|nmod|xenograft days|dep|injection was|nmod|days was|nsubj|accumulation accumulation|nmod|tumor tumor|acl|END_ENTITY Four days after injection of 111In-Nd2 into athymic nude_mice bearing SW1990 xenograft there was a higher accumulation in the tumor compared to 111In-normal mouse IgG1 . 11159212 3 111In-octreotide 669,685 VMAT1 564,569 111In-octreotide VMAT1 MESH:C094279 6570 Chemical Gene using|xcomp|START_ENTITY visualized|xcomp|using visualized|nmod|expression expression|nmod|receptors receptors|conj|END_ENTITY Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine . 11159212 3 111In-octreotide 669,685 VMAT2 574,579 111In-octreotide VMAT2 MESH:C094279 6571 Chemical Gene using|xcomp|START_ENTITY visualized|xcomp|using visualized|nmod|expression expression|nmod|receptors receptors|conj|VMAT1 VMAT1|conj|END_ENTITY Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine . 2964877 3 111In-oxine 446,457 CIG 552,555 111In-oxine CIG MESH:C032950 2335 Chemical Gene labelled|advcl|START_ENTITY labelled|nmod|globulin globulin|appos|END_ENTITY To examine cell adhesion , endothelial cells were labelled with 111In-oxine and inoculated onto prosthetic wells previously prepared with either cold insoluble globulin -LRB- CIG -RRB- , 1 % gelatin , alginate or left untreated as a control . 7659388 1 111In-oxine 192,203 interleukin-6 356,369 111In-oxine interleukin-6 MESH:C032950 3569 Chemical Gene imaging|amod|START_ENTITY doses|nmod|imaging macrophages|nmod|doses labelling|nmod|macrophages damage|nsubj|labelling damage|dobj|viability viability|conj|competence competence|nmod|cells cells|dep|secretion secretion|amod|factor-alpha factor-alpha|conj|END_ENTITY The labelling of ex-vivo activated macrophages with doses of 111In-oxine sufficient for gamma camera imaging does not damage cell viability or the functional competence of cells -LRB- secretion of tumour necrosis factor-alpha and interleukin-6 -RRB- . 1658591 10 111In-oxine 889,900 LAK 910,913 111In-oxine LAK MESH:C032950 71481(Tax:10090) Chemical Gene cells|amod|START_ENTITY cells|compound|END_ENTITY In experimental study , accumulation of 111In-oxine labelled LAK cells in mouse 3LL lung_cancer was augmented in splenectomized ones . 15285807 5 111In-Oxine 699,710 DC 662,664 111In-Oxine DC MESH:C032950 20299(Tax:10090) Chemical Gene 99mTc-HMPAO|conj|START_ENTITY labelled|advcl|99mTc-HMPAO labelled|nsubjpass|END_ENTITY METHODS : DC were labelled with 99mTc-HMPAO or 111In-Oxine , and the presence of labelled DC in regional lymph nodes was evaluated at pre-set times up to a maximum of 72 h after inoculation . 15285807 5 111In-Oxine 699,710 DC 741,743 111In-Oxine DC MESH:C032950 20299(Tax:10090) Chemical Gene 99mTc-HMPAO|conj|START_ENTITY labelled|advcl|99mTc-HMPAO labelled|conj|evaluated evaluated|nsubjpass|presence presence|nmod|END_ENTITY METHODS : DC were labelled with 99mTc-HMPAO or 111In-Oxine , and the presence of labelled DC in regional lymph nodes was evaluated at pre-set times up to a maximum of 72 h after inoculation . 9002771 1 111In-pentetreotide 286,305 CEA 260,263 111In-pentetreotide CEA MESH:C081788 5670 Chemical Gene scintigraphy|amod|START_ENTITY using|dobj|scintigraphy detected|xcomp|using detected|nsubjpass|recurrences recurrences|nmod|medullary_thyroid_carcinoma medullary_thyroid_carcinoma|nmod|patients patients|nmod|levels levels|nmod|END_ENTITY Local and lymphnodal recurrences of medullary_thyroid_carcinoma -LRB- MTC -RRB- in thyroidectomy patients with elevated plasma levels of calcitonin and/or CEA can be detected using 111In-pentetreotide -LRB- Octreoscan : OCT -RRB- scintigraphy , although the sensitivity of this technique in localizing an intrathyroid recurrence of tumor is affected by the low target/non-target uptake ratio . 8964877 17 111In-pentetreotide 1904,1923 IGF-I 1996,2001 111In-pentetreotide IGF-I MESH:C081788 3479 Chemical Gene scintigraphy|amod|START_ENTITY subjected|nmod|scintigraphy patients|acl|subjected had|nmod|patients had|parataxis|obtained obtained|nsubjpass|normalization normalization|nmod|GH GH|conj|END_ENTITY Of the 26 patients subjected to 111In-pentetreotide scintigraphy , 13 had significant tracer uptake : normalization of GH and IGF-I was obtained in 8 patients . 22785503 2 111In-pentetreotide 284,303 OCT 317,320 111In-pentetreotide OCT MESH:C081788 5362 Chemical Gene START_ENTITY|appos|OctreoScan OctreoScan|dep|END_ENTITY A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients . 22785503 2 111In-pentetreotide 284,303 OCT 367,370 111In-pentetreotide OCT MESH:C081788 5362 Chemical Gene PET/CT|conj|START_ENTITY indicating|nsubj|PET/CT indicating|nmod|END_ENTITY A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients . 22785503 2 111In-pentetreotide 284,303 OCT 417,420 111In-pentetreotide OCT MESH:C081788 5362 Chemical Gene PET/CT|conj|START_ENTITY indicating|nsubj|PET/CT presented|advcl|indicating presented|conj|compared compared|xcomp|END_ENTITY A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients . 9002771 1 111In-pentetreotide 286,305 OCT 319,322 111In-pentetreotide OCT MESH:C081788 5362 Chemical Gene scintigraphy|amod|START_ENTITY scintigraphy|appos|Octreoscan Octreoscan|dep|END_ENTITY Local and lymphnodal recurrences of medullary_thyroid_carcinoma -LRB- MTC -RRB- in thyroidectomy patients with elevated plasma levels of calcitonin and/or CEA can be detected using 111In-pentetreotide -LRB- Octreoscan : OCT -RRB- scintigraphy , although the sensitivity of this technique in localizing an intrathyroid recurrence of tumor is affected by the low target/non-target uptake ratio . 8895910 7 111In-pentetreotide 931,950 somatostatin 808,820 111In-pentetreotide somatostatin MESH:C081788 6750 Chemical Gene scintigraphy|amod|START_ENTITY outcome|nmod|scintigraphy affect|dobj|outcome affect|nsubj|detection detection|nmod|END_ENTITY The detection of somatostatin within the tumour -LRB- 2 patients -RRB- , or negative octreotide challenges -LRB- 2 patients -RRB- , did not affect the outcome of 111In-pentetreotide scintigraphy . 9516858 7 111In-pentetreotide 1120,1139 somatostatin 1184,1196 111In-pentetreotide somatostatin MESH:C081788 6750 Chemical Gene using|xcomp|START_ENTITY using|nsubj|tumours tumours|acl|expressing expressing|dobj|receptors receptors|compound|END_ENTITY Scintigraphy using 111In-pentetreotide identified tumours expressing high-affinity somatostatin receptors in vivo . 9042206 4 111In-ZCE025 649,661 CEA 697,700 111In-ZCE025 CEA null 1084 Chemical Gene START_ENTITY|appos|END_ENTITY For mice given 111In-ZCE025 , an anti-carcinoembryonic antigen -LRB- CEA -RRB- MAb , the biodistribution of activity was determined 7 days later . 10536187 10 111In-Zevalin 1672,1685 CD20 1641,1645 111In-Zevalin CD20 null 12482(Tax:10090) Chemical Gene accumulated|nsubj|START_ENTITY demonstrated|ccomp|accumulated demonstrated|nsubj|Studies Studies|nmod|mice mice|acl|bearing bearing|dobj|tumors tumors|nummod|END_ENTITY Studies in athymic mice bearing CD20 + tumors demonstrated that 111In-Zevalin accumulated in the tumors preferentially compared with normal organs . 13677323 8 1,1,1-kestopentaose 996,1015 DP5 934,937 1,1,1-kestopentaose DP5 MESH:C082830 8739 Chemical Gene kestopentaose|conj|START_ENTITY ,1|amod|kestopentaose ,1|nsubj|fructans fructans|compound|END_ENTITY The three major DP5 fructans are 1_6 ,1 - kestopentaose , 1,1 _ 6-kestopentaose and 1,1,1-kestopentaose . 20610725 4 111-nucleotide 579,593 7SL 614,617 111-nucleotide 7SL MESH:D009711 6029 Chemical Gene portion|amod|START_ENTITY portion|nmod|END_ENTITY Nuclease mapping showed that 7SLrem is a 111-nucleotide internal portion of 7SL , with 5 ' and 3 ' ends corresponding to unpaired loops in the 7SL two-dimensional structure . 20610725 4 111-nucleotide 579,593 7SL 678,681 111-nucleotide 7SL MESH:D009711 6029 Chemical Gene portion|amod|START_ENTITY portion|advcl|ends ends|nmod|loops loops|nmod|structure structure|nummod|END_ENTITY Nuclease mapping showed that 7SLrem is a 111-nucleotide internal portion of 7SL , with 5 ' and 3 ' ends corresponding to unpaired loops in the 7SL two-dimensional structure . 15811676 0 1,1,1-TCA 106,115 CCl4 97,101 1,1,1-TCA CCl4 null 6351 Chemical Gene END_ENTITY|conj|START_ENTITY Laboratory batch experiments of the combined effects of ultrasound and air_stripping in removing CCl4 and 1,1,1-TCA from water . 15811676 1 1,1,1-TCA 238,247 CCl4 205,209 1,1,1-TCA CCl4 null 6351 Chemical Gene carbon_tetrachloride|appos|START_ENTITY carbon_tetrachloride|appos|END_ENTITY Ultrasonic and air-stripping techniques for removal of carbon_tetrachloride -LRB- CCl4 -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- from water were studied in batch experiments . 23479748 4 1,1,1-TCA 1007,1016 DcrA 769,773 1,1,1-TCA DcrA null 10311 Chemical Gene CF|conj|START_ENTITY 1,1-dichloroethane|conj|CF dechlorinates|dobj|1,1-dichloroethane share|parataxis|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 23479748 4 1,1,1-TCA 1007,1016 DcrA 954,958 1,1,1-TCA DcrA null 10311 Chemical Gene CF|conj|START_ENTITY 1,1-dichloroethane|conj|CF dechlorinates|dobj|1,1-dichloroethane dechlorinates|nsubj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 23479748 4 1,1,1-TCA 914,923 DcrA 769,773 1,1,1-TCA DcrA null 10311 Chemical Gene 1,1,1-trichloroethane|appos|START_ENTITY chloroform|conj|1,1,1-trichloroethane dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 23479748 4 1,1,1-TCA 914,923 DcrA 954,958 1,1,1-TCA DcrA null 10311 Chemical Gene 1,1,1-trichloroethane|appos|START_ENTITY chloroform|conj|1,1,1-trichloroethane dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|parataxis|dechlorinates dechlorinates|nsubj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 17056695 11 1,1,1-TCA 1565,1574 KB-1 1481,1485 1,1,1-TCA KB-1 null 390221 Chemical Gene present|nummod|START_ENTITY inhibited|nmod|present inhibited|nsubjpass|Dechlorination Dechlorination|nmod|END_ENTITY Dechlorination of cis-dichloroethene -LRB- cDCE -RRB- and vinyl_chloride -LRB- VC -RRB- in KB-1 , a chloroethene-degrading culture used for bioaugmentation , was inhibited with 1,1,1-TCA present . 17056695 12 1,1,1-TCA 1682,1691 KB-1 1589,1593 1,1,1-TCA KB-1 null 390221 Chemical Gene dechlorinated|nsubjpass|START_ENTITY demonstrated|advcl|dechlorinated proceeded|advcl|demonstrated proceeded|advcl|coinoculated coinoculated|nsubjpass|END_ENTITY When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE . 17056695 12 1,1,1-TCA 1682,1691 KB-1 1786,1790 1,1,1-TCA KB-1 null 390221 Chemical Gene dechlorinated|nsubjpass|START_ENTITY demonstrated|advcl|dechlorinated demonstrated|dobj|application application|nmod|cultures cultures|compound|MS MS|conj|END_ENTITY When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE . 17056695 12 1,1,1-TCA 1851,1860 KB-1 1589,1593 1,1,1-TCA KB-1 null 390221 Chemical Gene cocontaminated|nmod|START_ENTITY sites|acl|cocontaminated cobioaugmentation|nmod|sites demonstrated|nmod|cobioaugmentation proceeded|advcl|demonstrated proceeded|advcl|coinoculated coinoculated|nsubjpass|END_ENTITY When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE . 17056695 12 1,1,1-TCA 1851,1860 KB-1 1786,1790 1,1,1-TCA KB-1 null 390221 Chemical Gene cocontaminated|nmod|START_ENTITY sites|acl|cocontaminated cobioaugmentation|nmod|sites demonstrated|nmod|cobioaugmentation demonstrated|dobj|application application|nmod|cultures cultures|compound|MS MS|conj|END_ENTITY When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE . 23904257 8 1,1,1-TCA 1469,1478 NO3 1497,1500 1,1,1-TCA NO3 null 4681 Chemical Gene removal|nummod|START_ENTITY removal|conj|END_ENTITY HCO3 -LRB- - -RRB- anions had a accelerative effect on 1,1,1-TCA removal , and both NO3 -LRB- - -RRB- and HA had inhibitory effects . 28424844 6 1,1,1-TCA 1001,1010 THM1 918,922 1,1,1-TCA THM1 null 79809 Chemical Gene chloroform|conj|START_ENTITY dehalogenation|nmod|chloroform found|nmod|dehalogenation found|nsubjpass|END_ENTITY THM1 , was found to couple growth with dehalogenation of chloroform , bromoform , and 1,1,1-TCA . 28424844 7 1,1,1-TCA 1132,1141 THM1 1019,1023 1,1,1-TCA THM1 null 79809 Chemical Gene dehalogenation|nummod|START_ENTITY chloroform|conj|dehalogenation catalyzes|dobj|chloroform ThmA|acl:relcl|catalyzes harbors|dobj|ThmA harbors|nsubj|END_ENTITY Strain THM1 harbors a newly identified reductive dehalogenase -LRB- RDase -RRB- , ThmA , which catalyzes chloroform , bromoform , and 1,1,1-TCA dehalogenation . 28424844 7 1,1,1-TCA 1132,1141 ThmA 1083,1087 1,1,1-TCA ThmA null 117193 Chemical Gene dehalogenation|nummod|START_ENTITY chloroform|conj|dehalogenation catalyzes|dobj|chloroform END_ENTITY|acl:relcl|catalyzes Strain THM1 harbors a newly identified reductive dehalogenase -LRB- RDase -RRB- , ThmA , which catalyzes chloroform , bromoform , and 1,1,1-TCA dehalogenation . 3245236 2 1,1,1-TCE 143,152 cytochrome_P-450 369,385 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene 1,1,1-trichloroethane|appos|START_ENTITY action|nmod|1,1,1-trichloroethane studied|nsubjpass|action studied|nmod|determination determination|conj|change change|nmod|END_ENTITY The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 . 3245236 2 1,1,1-TCE 315,324 cytochrome_P-450 369,385 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene metabolism|nummod|START_ENTITY consumption|conj|metabolism rates|nmod|consumption determination|nmod|rates determination|conj|change change|nmod|END_ENTITY The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 . 3245236 8 1,1,1-TCE 780,789 cytochrome_P-450 799,815 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene bound|nsubj|START_ENTITY bound|nmod|END_ENTITY Spectral studies indicated that 1,1,1-TCE bound to cytochrome_P-450 and showed a type I spectral change . 3988004 4 1,1,1-TCE 656,665 cytochrome_P-450 688,704 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene bound|nsubj|START_ENTITY bound|nmod|END_ENTITY However , 1,1,1-TCE bound more tightly to cytochrome_P-450 and seemed to be only slowly metabolized compared to 1,1,2-TCE . 3988004 8 1,1,1-TCE 1388,1397 cytochrome_P-450 1401,1417 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene END_ENTITY|nummod|START_ENTITY Considering our previous data indicating that TCE did not stimulate mitochondrial respiration , it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome_P-450 than the amount which was necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system . 3988004 8 1,1,1-TCE 1534,1543 cytochrome_P-450 1401,1417 1,1,1-TCE cytochrome P-450 CHEBI:36015 25251(Tax:10116) Chemical Gene effect|nmod|START_ENTITY due|nmod|effect due|nsubj|amount amount|nmod|consumption consumption|acl|associated associated|nmod|binding binding|nmod|END_ENTITY Considering our previous data indicating that TCE did not stimulate mitochondrial respiration , it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome_P-450 than the amount which was necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system . 1489524 5 1,1,1-TCE 903,912 GPT 853,856 1,1,1-TCE GPT CHEBI:36015 81670(Tax:10116) Chemical Gene did|nsubj|START_ENTITY serum|advcl|did led|nmod|serum led|nmod|END_ENTITY It led to much higher values for GPT , SDH and GDH both in serum and perfusate than 1,1,1-TCE did -LRB- P < 0.01 -RRB- . 11090101 6 1,1,1-trichlorethane 541,561 NR1/2A 707,713 1,1,1-trichlorethane NR1/2A CHEBI:36015 397953;100127346 Chemical Gene benzene|dep|START_ENTITY solvents|dep|benzene effects|nmod|solvents report|nmod|effects report|nmod|currents currents|acl|measured measured|advcl|expressing expressing|dobj|subtypes subtypes|compound|END_ENTITY We now report on the effects of other commonly abused solvents -LRB- benzene , m-xylene , ethylbenzene , propylbenzene , 1,1,1-trichlorethane -LRB- TCE -RRB- and those of a convulsive solvent , 2,2,2-trifluoroethyl _ ether -LRB- flurothyl -RRB- , on NMDA-induced currents measured in XENOPUS oocytes expressing NR1/2A or NR1/2B receptor subtypes . 11090101 6 1,1,1-trichlorethane 541,561 NR1/2B 717,723 1,1,1-trichlorethane NR1/2B CHEBI:36015 100126610(Tax:8355) Chemical Gene benzene|dep|START_ENTITY solvents|dep|benzene effects|nmod|solvents report|nmod|effects report|nmod|currents currents|acl|measured measured|advcl|expressing expressing|dobj|subtypes subtypes|compound|NR1/2A NR1/2A|conj|END_ENTITY We now report on the effects of other commonly abused solvents -LRB- benzene , m-xylene , ethylbenzene , propylbenzene , 1,1,1-trichlorethane -LRB- TCE -RRB- and those of a convulsive solvent , 2,2,2-trifluoroethyl _ ether -LRB- flurothyl -RRB- , on NMDA-induced currents measured in XENOPUS oocytes expressing NR1/2A or NR1/2B receptor subtypes . 11718349 1 1,1,1-trichloroethane 167,188 CCl4 150,154 1,1,1-trichloroethane CCl4 MESH:C024566 6351 Chemical Gene END_ENTITY|conj|START_ENTITY The reductive dehalogenation of gas-phase chlorinated_alkanes -LRB- CCl4 , CHCl3 , and 1,1,1-trichloroethane -RRB- and alkenes -LRB- perchloroethene -LRB- PCE -RRB- and trichloroethene -LRB- TCE -RRB- -RRB- was conducted in a modified fuel cell . 15811676 1 1,1,1-trichloroethane 215,236 CCl4 205,209 1,1,1-trichloroethane CCl4 MESH:C024566 6351 Chemical Gene carbon_tetrachloride|conj|START_ENTITY carbon_tetrachloride|appos|END_ENTITY Ultrasonic and air-stripping techniques for removal of carbon_tetrachloride -LRB- CCl4 -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- from water were studied in batch experiments . 8981595 1 1,1,1-trichloroethane 125,146 CD-1 209,213 1,1,1-trichloroethane CD-1 MESH:C024566 111334(Tax:10090) Chemical Gene effects|nmod|START_ENTITY examined|nsubjpass|effects examined|nmod|mice mice|compound|END_ENTITY The effects of 1,1,1-trichloroethane -LRB- TCE -RRB- on physical and behavioral development were examined in CD-1 mice prenatally exposed under two regimens . 11521816 8 1,1,1-trichloroethane 1462,1483 cis-1 1638,1643 1,1,1-trichloroethane cis-1 MESH:C024566 8651 Chemical Gene 1,1-dichloroethane|amod|START_ENTITY conditions|amod|1,1-dichloroethane solutions|nmod|conditions Using|dobj|solutions Using|conj|chloroethane chloroethane|dobj|Consistent Consistent|amod|END_ENTITY Using these analytical solutions , for the sulfate-reducing field conditions documented for this site , perchloroethene , trichloroethene , 1,1,1-trichloroethane , 1,1-dichloroethane , and chloroethane all degraded with half-lives ranging from 5 to 115 d. Consistent with other studies of sulfate-reducing conditions , cis-1 ,2 - dichloroethene did not chemically degrade at a measurable rate . 22071373 2 1,1,1-trichloroethane 409,430 cis-1 367,372 1,1,1-trichloroethane cis-1 MESH:C024566 8651 Chemical Gene dichloroethylene|conj|START_ENTITY tetrachloroethylene|amod|dichloroethylene tetrachloroethylene|amod|END_ENTITY The chlorinated compounds include tetrachloroethylene , trichloroethylene , cis-1 ,2 - dichloroethylene , vinyl_chloride , 1,1,1-trichloroethane , 1,1-dichloroethane , 1,2-dichloroethane , chloroethane , carbon_tetrachloride , chloroform , dichloromethane , and chloromethane . 6802168 6 1,1,1-trichloroethane 738,759 CO2 726,729 1,1,1-trichloroethane CO2 MESH:C024566 717 Chemical Gene size|conj|START_ENTITY size|nmod|END_ENTITY Also the Bohr dead space was found to be of similar size for CO2 and for 1,1,1-trichloroethane . 6594588 0 1,1,1-trichloroethane 36,57 Cyrano 0,6 1,1,1-trichloroethane Cyrano MESH:C024566 729082 Chemical Gene loved|xcomp|START_ENTITY loved|nsubj|Bergerac Bergerac|compound|END_ENTITY Cyrano De Bergerac would have loved 1,1,1-trichloroethane . 10232850 6 1,1,1-trichloroethane 838,859 cytochrome_P450 907,922 1,1,1-trichloroethane cytochrome P450 MESH:C024566 25251(Tax:10116) Chemical Gene means|nmod|START_ENTITY drug-induced|nmod|means compound|amod|drug-induced compound|acl:relcl|pseudosubstrate pseudosubstrate|nmod|END_ENTITY This method was evaluated for the determination of drug-induced in vivo generation of oxidative stress by means of 1,1,1-trichloroethane -LRB- TCE -RRB- a compound that is a pseudosubstrate for cytochrome_P450 and is known to induce oxygen reductase activity of this enzyme -LRB- s -RRB- . 3245236 2 1,1,1-trichloroethane 120,141 cytochrome_P-450 369,385 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene action|nmod|START_ENTITY studied|nsubjpass|action studied|nmod|determination determination|conj|change change|nmod|END_ENTITY The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 . 3988004 1 1,1,1-trichloroethane 118,139 cytochrome_P-450 165,181 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene START_ENTITY|conj|1,1,2-TCE 1,1,2-TCE|nmod|END_ENTITY The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital . 3988004 1 1,1,1-trichloroethane 118,139 cytochrome_P-450 261,277 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene interactions|nmod|START_ENTITY observed|nsubjpass|interactions observed|xcomp|using using|xcomp|measure measure|dobj|changes changes|nmod|END_ENTITY The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital . 578726 7 1,1,1-trichloroethane 1075,1096 cytochrome_P-450 1142,1158 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene exposure|nmod|START_ENTITY depressed|nsubj|exposure depressed|dobj|content content|amod|END_ENTITY The exposure to 1,1,1-trichloroethane on the 5th day depressed also the microsomal cytochrome_P-450 content in liver of rats whereas trichloroethylene increased the hemochrome content slightly at the same time . 6722974 1 1,1,1-trichloroethane 87,108 cytochrome_P-450 183,199 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene 1,2-Dichloroethane|amod|START_ENTITY metabolized|nsubjpass|1,2-Dichloroethane metabolized|nmod|END_ENTITY 1,2-Dichloroethane , 1,1,1-trichloroethane and 1,1,2,2-tetrachloroethane appear to be metabolized by hepatic nuclear cytochrome_P-450 . 6722974 5 1,1,1-trichloroethane 723,744 cytochrome_P-450 869,885 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 25251(Tax:10116) Chemical Gene 2,2,2-trichloroethanol|advcl|START_ENTITY 1,2-dichloroethane|conj|2,2,2-trichloroethanol chloroacetaldehyde|acl|1,2-dichloroethane produced|nsubjpass|chloroacetaldehyde produced|nmod|END_ENTITY chloroacetaldehyde from 1,2-dichloroethane , 2,2,2-trichloroethanol from 1,1,1-trichloroethane , and dichloroacetic_acid from 1,1,2,2-tetrachloroethane , were also produced from the three chloroalkanes by hepatic nuclear cytochrome_P-450 . 7285278 4 1,1,1-trichloroethane 623,644 cytochrome_P-450 706,722 1,1,1-trichloroethane cytochrome P-450 MESH:C024566 4051 Chemical Gene 2,2,2-trichloroethanol|nsubj|START_ENTITY 2,2,2-trichloroethanol|nmod|END_ENTITY 1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively . 23479748 4 1,1,1-trichloroethane 891,912 DcrA 769,773 1,1,1-trichloroethane DcrA MESH:C024566 10311 Chemical Gene chloroform|conj|START_ENTITY dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 23479748 4 1,1,1-trichloroethane 891,912 DcrA 954,958 1,1,1-trichloroethane DcrA MESH:C024566 10311 Chemical Gene chloroform|conj|START_ENTITY dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|parataxis|dechlorinates dechlorinates|nsubj|END_ENTITY The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA . 20123932 1 1,1,1-trichloroethane 322,343 GABAA 148,153 1,1,1-trichloroethane GABAA MESH:C024566 14405(Tax:10090) Chemical Gene effects|nmod|START_ENTITY transduction|nmod|effects systems|nmod|transduction involvement|conj|systems involvement|nmod|END_ENTITY The present study examined the involvement of the GABAA , N-methyl-D-aspartate -LRB- NMDA -RRB- , nicotinic acetylcholine , and mu-opioid receptor systems in the transduction of the discriminative stimulus effects of the abused inhalant 1,1,1-trichloroethane -LRB- TCE -RRB- . 12602951 2 1,1,1-trichloroethane 555,576 GMIPp 294,299 1,1,1-trichloroethane GMIPp MESH:C024566 51291 Chemical Gene determined|advcl|START_ENTITY acceptors|acl|determined basicities|nmod|acceptors acidities|conj|basicities made|dobj|acidities made|nsubjpass|Comparison Comparison|nmod|values values|compound|END_ENTITY Comparison of the GMIPp values is made with two experimental hydrogen-bond scales : i -RRB- the hydrogen-bond basicity scale for N-heteroaromatics in carbon_tetrachloride , and ii -RRB- the hydrogen-bond acidities for NH/OH donors and hydrogen-bond basicities of N/O acceptors determined in 1,1,1-trichloroethane . 1463393 3 1,1,1-trichloroethane 880,901 GPT 944,947 1,1,1-trichloroethane GPT MESH:C024566 81670(Tax:10116) Chemical Gene increase|amod|START_ENTITY ppm|dobj|increase ppm|nmod|activity activity|compound|END_ENTITY In contrast , coadministration of 50 ppm trichloroethylene and 200 ppm 1,1,1-trichloroethane decreased CCl4-induced increase in plasma GPT activity , though these exposures did not influence the liver MDA content . 11379082 2 1,1,1-trichloroethane 423,444 GroEL 476,481 1,1,1-trichloroethane GroEL MESH:C024566 3329 Chemical Gene benzoquinone|conj|START_ENTITY benzoquinone|dep|expression expression|compound|END_ENTITY At the EC25 concentration , pentachlorophenol -LRB- PCP -RRB- , cadmium , nickel , 2,4-dichloroaniline , benzoquinone , 2,4-dinitrophenol , and 1,1,1-trichloroethane all rapidly induced measurable GroEL expression , even though the time-dependent response for each of these compounds was somewhat varied . 10541915 8 1,1,1-trichloroethane 968,989 IL-1beta 991,999 1,1,1-trichloroethane IL-1beta MESH:C024566 3553 Chemical Gene 82.4|amod|START_ENTITY 82.4|compound|END_ENTITY RESULTS : Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane -LRB- IL-1beta 82.4 vs. 28.8 pg/ml -LRB- medians -RRB- , P = 0.003 ; IL-6 12.2 vs. 7.2 pg/ml , P = 0 . 10541915 8 1,1,1-trichloroethane 968,989 IL-6 1040,1044 1,1,1-trichloroethane IL-6 MESH:C024566 3569 Chemical Gene 82.4|amod|START_ENTITY 82.4|appos|P P|dep|END_ENTITY RESULTS : Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane -LRB- IL-1beta 82.4 vs. 28.8 pg/ml -LRB- medians -RRB- , P = 0.003 ; IL-6 12.2 vs. 7.2 pg/ml , P = 0 . 16404204 5 1,1,1-trichloroethane 669,690 JP4 696,699 1,1,1-trichloroethane JP4 MESH:C024566 84502 Chemical Gene START_ENTITY|conj|gasoline gasoline|compound|END_ENTITY RESULTS : For the 1973-2000 period , there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene , 1,1,1-trichloroethane , and JP4 gasoline compared with unexposed subjects -LRB- all P < 0.05 -RRB- . 9237768 6 1,1,1-trichloroethane 859,880 JP-4 852,856 1,1,1-trichloroethane JP-4 MESH:C024566 84502 Chemical Gene fuel|amod|START_ENTITY fuel|appos|END_ENTITY Sister-chromatid_exchanges -LRB- SCE -RRB- and micronuclei -LRB- MN -RRB- frequency were measured in conjunction with air sampling and expired breath analysis for jet fuel -LRB- JP-4 -RRB- , 1,1,1-trichloroethane , methyl_ethyl_ketone , xylenes , toluene and methylene_chloride . 11409535 1 1,1,1-trichloroethane 271,292 PERC 260,264 1,1,1-trichloroethane PERC MESH:C024566 291567(Tax:10116) Chemical Gene trichloroethylene|conj|START_ENTITY trichloroethylene|conj|tetrachloroethylene tetrachloroethylene|appos|perchloroethylene perchloroethylene|dep|END_ENTITY The volatile organic solvents trichloroethylene -LRB- TCE -RRB- , tetrachloroethylene -LRB- perchloroethylene , PERC -RRB- , and 1,1,1-trichloroethane -LRB- methylchloroform , MC -RRB- are widely distributed environmental pollutants and common contaminants of many chemical waste sites . 24910396 1 1,1,1-trichloroethane 279,300 PERC 359,363 1,1,1-trichloroethane PERC MESH:C024566 170826(Tax:10090) Chemical Gene 1,2-dichloroethane|conj|START_ENTITY effects|acl|1,2-dichloroethane profiles|nmod|effects profiles|appos|END_ENTITY The present study aimed to clarify whether dose-response profiles of acute behavioral effects of 1,2-dichloroethane -LRB- DCE -RRB- , 1,1,1-trichloroethane -LRB- TCE -RRB- , trichloroethylene -LRB- TRIC -RRB- , and tetrachloroethylene -LRB- PERC -RRB- differ . 19005803 2 1,1,1-trichloroethane 366,387 R12 494,497 1,1,1-trichloroethane R12 MESH:C024566 2840 Chemical Gene VCCs|amod|START_ENTITY VCCs|conj|CFCs CFCs|dep|trichlorofluoromethane trichlorofluoromethane|conj|dichlorodifluoromethane dichlorodifluoromethane|dep|END_ENTITY Fully halogenated VCCs -LRB- tetrachloroethylene , 1,1,1-trichloroethane , tetrachloromethane and dichloromethane -RRB- and CFCs -LRB- trichlorofluoromethane -LRB- R11 -RRB- , dichlorodifluoromethane -LRB- R12 -RRB- and 1,1,2-trichlorotrifluoroethane -LRB- R113 -RRB- -RRB- were degraded under anaerobic conditions in addition to the methanogenic bacteria in municipal solid waste -LRB- MSW -RRB- and organic wastes . 2874801 5 1,1,1-trichloroethane 660,681 sec-1 784,789 1,1,1-trichloroethane sec-1 MESH:C024566 653677 Chemical Gene PEG-hemin|nmod|START_ENTITY activity|nmod|PEG-hemin greater|nsubj|activity greater|parataxis|X X|amod|END_ENTITY The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide . 2874801 5 1,1,1-trichloroethane 660,681 sec-1 926,931 1,1,1-trichloroethane sec-1 MESH:C024566 653677 Chemical Gene PEG-hemin|nmod|START_ENTITY activity|nmod|PEG-hemin greater|nsubj|activity greater|parataxis|X X|conj|END_ENTITY The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide . 2874801 5 1,1,1-trichloroethane 741,762 sec-1 784,789 1,1,1-trichloroethane sec-1 MESH:C024566 653677 Chemical Gene values|nmod|START_ENTITY X|nsubj|values X|amod|END_ENTITY The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide . 2874801 5 1,1,1-trichloroethane 741,762 sec-1 926,931 1,1,1-trichloroethane sec-1 MESH:C024566 653677 Chemical Gene values|nmod|START_ENTITY X|nsubj|values X|conj|END_ENTITY The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide . 10508110 2 1,1,1-trichloroethane 102,123 TA5 150,153 1,1,1-trichloroethane TA5 MESH:C024566 83551 Chemical Gene strains|nmod|START_ENTITY strains|dep|bacteria bacteria|conj|END_ENTITY Two strains of 1,1,1-trichloroethane -LRB- TCA -RRB- - degrading bacteria , TA5 and TA27 , were isolated from soil and identified as Mycobacterium spp . 2139502 6 1.1.1-trichloroethane 728,749 PCB 809,812 1.1.1-trichloroethane PCB MESH:C024566 5091 Chemical Gene toluene|conj|START_ENTITY toluene|conj|END_ENTITY An approach in setting standards of indoor air quality for frequent organic substances like toluene , xylene , styrene , dichloromethane , 1.1.1-trichloroethane , trichloroethene , tetrachloroethene , pentachlorophenol and PCB is presented , incorporating adequate protection margins . 27328667 1 1,1,1-trifluoro-2-iodoethane 199,227 C-3 136,139 1,1,1-trifluoro-2-iodoethane C-3 MESH:C000591752 718 Chemical Gene using|xcomp|START_ENTITY imidazoheterocycles|acl|using trifluoroethylation|nmod|imidazoheterocycles trifluoroethylation|amod|selective selective|amod|END_ENTITY UNASSIGNED : A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed . 18717564 1 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one 243,299 III 219,222 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one III null 25021114 Chemical Gene -RSB-|dep|START_ENTITY 6|amod|-RSB- synthesized|nsubjpass|6 4|acl:relcl|synthesized 3Co|dep|4 3Co|appos|END_ENTITY A mixed-valence Co -LRB- II -RRB- / Co -LRB- III -RRB- heptanuclear wheel -LSB- Co -LRB- II -RRB- 3Co -LRB- III -RRB- 4 -LRB- L -RRB- 6 -LRB- MeO -RRB- 6 -RSB- -LRB- LH2 = 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one -RRB- has been synthesized and its crystal structure determined using single-crystal X-ray diffraction . 8055254 3 1,1,1-trifluorotetradecan-2-one 660,691 EAG 782,785 1,1,1-trifluorotetradecan-2-one EAG null 3756 Chemical Gene -16|conj|START_ENTITY carried|xcomp|-16 carried|parataxis|displayed displayed|nmod|END_ENTITY In the laboratory experiments , carried out by pre-exposure of males to vapors of the chemicals , alpha-naphthyl_trifluoromethyl_ketone , beta-naphthyl_trifluoromethyl_ketone , 1,1,1-trifluorotetradecan-2-one and -LRB- Z -RRB- -16 - nonadecen-14-yn-2-one displayed notable blockage of the pheromone detection on EAG . 3941075 3 11-21 425,430 myosin 480,486 11-21 myosin MESH:C065619 79784 Chemical Gene peptides|nummod|START_ENTITY phosphorylated|nsubjpass|peptides phosphorylated|nmod|chain chain|compound|END_ENTITY The peptides 11-19 , 11-20 , 11-21 , 11-22 , and 11-23 were all phosphorylated by the myosin light chain kinase with similar apparent Km values in the range 11-17 microM . 824867 3 1,1,2,2-tetrachloroethane 269,294 CCl4 381,385 1,1,2,2-tetrachloroethane CCl4 MESH:C015530 116637(Tax:10116) Chemical Gene given|nsubjpass|START_ENTITY given|nmod|level level|amod|equivalent equivalent|nmod|quarter quarter|nmod|that that|nmod|END_ENTITY Due to high toxicity , 1,1,2,2-tetrachloroethane and pentachloroethane were given at a dose level equivalent to one quarter of that of CCl4 and the other chlorohydrocarbons -LRB- i.e. 2-6 mmol/kg -RRB- . 824867 8 1,1,2,2-tetrachloroethane 789,814 CCl4 783,787 1,1,2,2-tetrachloroethane CCl4 MESH:C015530 116637(Tax:10116) Chemical Gene END_ENTITY|conj|START_ENTITY Expoxide hydratase activity in rat liver declined significantly after CCl4 , 1,1,2,2-tetrachloroethane and pentachloroethane administrations . 3426575 1 1,1,2,2-tetrachloroethane 158,183 cytochrome_P-450 263,279 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY investigated|nsubjpass|oxidation investigated|conj|purified purified|xcomp|END_ENTITY The oxidation of 1,1,2,2-tetrachloroethane to dichloroacetic_acid was investigated with rat liver microsomes and purified cytochrome_P-450 . 6128194 6 1,1,2,2-tetrachloroethane 1186,1211 cytochrome_P-450 1230,1246 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene metabolized|nsubjpass|START_ENTITY metabolized|advcl|END_ENTITY The results are consistent with a scheme whereby 1,1,2,2-tetrachloroethane is metabolized by cytochrome_P-450 to dichloroacetyl_chloride , which can bind covalently to various nucleophiles or hydrolyze to dichloroacetic_acid . 6722974 10 1,1,2,2-tetrachloroethane 1799,1824 cytochrome_P-450 1650,1666 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene 1,2-dichloroethane|conj|START_ENTITY metabolism|acl|1,2-dichloroethane mediate|nsubj|metabolism mediate|advcl|exceed exceed|nsubj|metabolism metabolism|amod|dependent dependent|amod|END_ENTITY It is proposed that , although the cytochrome_P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei , the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome_P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds . 6722974 10 1,1,2,2-tetrachloroethane 1799,1824 cytochrome_P-450 1836,1852 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene 1,2-dichloroethane|conj|START_ENTITY metabolism|acl|1,2-dichloroethane metabolism|nmod|END_ENTITY It is proposed that , although the cytochrome_P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei , the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome_P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds . 6722974 1 1,1,2,2-tetrachloroethane 113,138 cytochrome_P-450 183,199 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene 1,1,1-trichloroethane|conj|START_ENTITY 1,2-Dichloroethane|amod|1,1,1-trichloroethane metabolized|nsubjpass|1,2-Dichloroethane metabolized|nmod|END_ENTITY 1,2-Dichloroethane , 1,1,1-trichloroethane and 1,1,2,2-tetrachloroethane appear to be metabolized by hepatic nuclear cytochrome_P-450 . 6722974 5 1,1,2,2-tetrachloroethane 775,800 cytochrome_P-450 869,885 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 25251(Tax:10116) Chemical Gene dichloroacetic_acid|advcl|START_ENTITY 1,2-dichloroethane|conj|dichloroacetic_acid chloroacetaldehyde|acl|1,2-dichloroethane produced|nsubjpass|chloroacetaldehyde produced|nmod|END_ENTITY chloroacetaldehyde from 1,2-dichloroethane , 2,2,2-trichloroethanol from 1,1,1-trichloroethane , and dichloroacetic_acid from 1,1,2,2-tetrachloroethane , were also produced from the three chloroalkanes by hepatic nuclear cytochrome_P-450 . 7285278 4 1,1,2,2-tetrachloroethane 781,806 cytochrome_P-450 706,722 1,1,2,2-tetrachloroethane cytochrome P-450 MESH:C015530 4051 Chemical Gene 1,1,2-trichloroethane|conj|START_ENTITY metabolites|acl|1,1,2-trichloroethane mono|nsubj|metabolites converted|advcl|mono converted|xcomp|2,2,2-trichloroethanol 2,2,2-trichloroethanol|nmod|END_ENTITY 1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively . 11944690 2 1,1,2,2-tetrachloroethane 341,366 exo-1 510,515 1,1,2,2-tetrachloroethane exo-1 MESH:C015530 9156 Chemical Gene occurred|advcl|START_ENTITY occurred|dep|,7 ,7|dep|epoxy-1 epoxy-1|dep|,4:5,8 ,4:5,8|amod|END_ENTITY Dehydrohalogenation -LRB- loss of HCI with the formation of a double bond -RRB- occurred at temperatures as low as 105-200 degrees C for 1,1,2,2-tetrachloroethane , lindane -LRB- 1,2,3,4,5,6-hexachlorocyclohexane , gamma-isomer -RRB- , and dieldrin -LRB- 1,2,3,4,10,10-hexachloro-6 ,7 - epoxy-1 ,4,4 a,5,6,7,8,8a-octahydro-endo , _ exo-1 ,4:5,8 - dimethanonaphthalene -RRB- . 3389679 2 1,1,2,2-tetrachloroethane 771,796 GGT 895,898 1,1,2,2-tetrachloroethane GGT MESH:C015530 116568(Tax:10116) Chemical Gene initiation|conj|START_ENTITY administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels . 9657282 2 1,1,2,2-tetrafluoroethyl-L-cysteine 255,290 TFEC 292,296 1,1,2,2-tetrafluoroethyl-L-cysteine TFEC null 26296(Tax:10116) Chemical Gene START_ENTITY|appos|END_ENTITY In this study , we have examined the ability of a single i.p. dose of 1,1,2,2-tetrafluoroethyl-L-cysteine -LRB- TFEC -RRB- , a major metabolite of tetrafluoroethylene , to produce hepatic and renal_injury in male and female rats . 3389679 2 1,1,2,2-TTCE 798,810 GGT 895,898 1,1,2,2-TTCE GGT null 116568(Tax:10116) Chemical Gene 1,1,2,2-tetrachloroethane|dep|START_ENTITY initiation|conj|1,1,2,2-tetrachloroethane administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels . 3389679 3 1,1,2,2-TTCE 927,939 GGT 999,1002 1,1,2,2-TTCE GGT null 116568(Tax:10116) Chemical Gene START_ENTITY|dep|increases increases|nmod|+ +|compound|END_ENTITY 1,1,2,2-TTCE , TTCY , and 1,1,2-TCE also induced significant increases in GGT + - foci when administered in the promotion protocol without DEN initiation . 24677167 2 1,1,2,3,3-pentamethylenepropane 300,331 DR1 378,381 1,1,2,3,3-pentamethylenepropane DR1 null 1810 Chemical Gene diradicals|amod|START_ENTITY analogues|nmod|diradicals analogues|dep|nitronyl_nitroxide nitronyl_nitroxide|appos|END_ENTITY We succeeded in synthesising heteroatom analogues of the 1,1,2,3,3-pentamethylenepropane -LRB- PMP -RRB- diradicals with two nitronyl_nitroxide -LRB- DR1 -RRB- and with two iminonitroxide -LRB- DR2 -RRB- fragments linked through the C -LRB- sp2 -RRB- atom of the nitrone group . 1846198 2 1,123-amino-acid 329,345 UL37 309,313 1,123-amino-acid UL37 null 2703358(Tax:10298) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY The UL37 gene encodes a 1,123-amino-acid protein of unknown function , while the 465-amino-acid UL38 protein is involved in capsid assembly . 1846198 2 1,123-amino-acid 329,345 UL38 400,404 1,123-amino-acid UL38 null 2703359(Tax:10298) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|advcl|involved involved|nsubjpass|protein protein|compound|END_ENTITY The UL37 gene encodes a 1,123-amino-acid protein of unknown function , while the 465-amino-acid UL38 protein is involved in capsid assembly . 8822954 6 1124ACA 1195,1202 GPI 1155,1158 1124ACA GPI null 2821 Chemical Gene heterozygote|nmod|START_ENTITY Kinki|nmod|heterozygote Kinki|compound|END_ENTITY We also identified GPI Kinki as a compound heterozygote of 1124ACA -- > AGA -LRB- 375Thr -- > Arg -RRB- / 1615GAC -- > AAC -LRB- 539Asp -- > Asn -RRB- . 15107826 4 1125A 687,692 SEP15 660,665 1125A SEP15 null 9403 Chemical Gene variant|amod|START_ENTITY variant|compound|END_ENTITY A SEP15 polymorphic variant , 1125A , resides in the SECIS recognition element in the 3 ' - UTR and may influence the efficiency of Sec incorporation into the protein during translation . 7506556 3 1125H 570,575 CD4 559,562 1125H CD4 null 920 Chemical Gene END_ENTITY|conj|START_ENTITY This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site . 7506556 3 1125H 570,575 gp120 494,499 1125H gp120 null 3700 Chemical Gene CD4|conj|START_ENTITY inhibited|nmod|CD4 overlaps|advcl|inhibited overlaps|dobj|site site|nmod|END_ENTITY This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site . 7506556 3 1125H 570,575 gp120 529,534 1125H gp120 null 3700 Chemical Gene CD4|conj|START_ENTITY inhibited|nmod|CD4 inhibited|nsubjpass|binding binding|nmod|END_ENTITY This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site . 7506556 4 1125H 693,698 gp120 850,855 1125H gp120 null 3700 Chemical Gene those|nmod|START_ENTITY those|conj|HuMAbs HuMAbs|acl|described described|advcl|documented documented|conj|reactivity reactivity|nmod|panel panel|nmod|mutants mutants|amod|END_ENTITY However , the 5145A epitope differs from those of 1125H and other anti-CD4-binding site HuMAbs previously described , as documented by the viral strain specificity of 5145A and its reactivity with a panel of gp120 mutants . 21264442 9 11276A 1705,1711 F12 1631,1634 11276A F12 null 2161 Chemical Gene F12|nmod|START_ENTITY produced|nsubj|F12 led|conj|produced led|nsubj|9775G_to_C 9775G_to_C|conj|11276G 11276G|nmod|mutations mutations|nmod|END_ENTITY In conclusion , the 9775G_to_C and 11276G to A mutations of F12 led to a CRM-negative and - positive FXII_deficiency , and the F12 with 11276A produced a dysfunctional type of FXII with a partial defect -LRB- 0.41-0 .45 -RRB- in prekallikrein cleavage activity . 21264442 9 11276A 1705,1711 F12 1696,1699 11276A F12 null 2161 Chemical Gene END_ENTITY|nmod|START_ENTITY In conclusion , the 9775G_to_C and 11276G to A mutations of F12 led to a CRM-negative and - positive FXII_deficiency , and the F12 with 11276A produced a dysfunctional type of FXII with a partial defect -LRB- 0.41-0 .45 -RRB- in prekallikrein cleavage activity . 10760578 1 112-amino_acid 61,75 Elongin_A 150,159 112-amino acid Elongin A MESH:C045451 855491(Tax:4932) Chemical Gene protein|amod|START_ENTITY protein|acl:relcl|binds binds|nmod|SIII SIII|conj|END_ENTITY Mammalian Elongin_C is a 112-amino_acid protein that binds to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor and to Elongin_A , the transcriptionally active subunit of the RNA polymerase II elongation factor , SIII . 10760578 1 112-amino_acid 61,75 Elongin_C 46,55 112-amino acid Elongin C MESH:C045451 856061(Tax:4932) Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY Mammalian Elongin_C is a 112-amino_acid protein that binds to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor and to Elongin_A , the transcriptionally active subunit of the RNA polymerase II elongation factor , SIII . 9341197 1 112-amino_acid 131,145 Elongin_C 116,125 112-amino acid Elongin C MESH:C045451 6921 Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein . 9341197 1 112-amino_acid 131,145 VHL 368,371 112-amino acid VHL MESH:C045451 7428 Chemical Gene protein|amod|START_ENTITY protein|acl:relcl|found found|nmod|subunit subunit|conj|containing containing|advcl|_ _|nsubj|_ _|appos|END_ENTITY Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein . 9341197 1 112-amino_acid 131,145 von_Hippel-Lindau 349,366 112-amino acid von Hippel-Lindau MESH:C045451 7428 Chemical Gene protein|amod|START_ENTITY protein|acl:relcl|found found|nmod|subunit subunit|conj|containing containing|advcl|_ _|nsubj|_ _|amod|END_ENTITY Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein . 1549120 3 112-amino-acid 549,563 TGF-beta 515,523 112-amino-acid TGF-beta null 7040 Chemical Gene polypeptide|amod|START_ENTITY homodimer|nmod|polypeptide homodimer|nsubj|form form|amod|END_ENTITY Each TGF-beta form is a homodimer of a 112-amino-acid polypeptide which is encoded as a larger polypeptide precursor . 10731035 9 1,12-DD 1174,1181 Ornithine_decarboxylase 1061,1084 1,12-DD Ornithine decarboxylase null 24609(Tax:10116) Chemical Gene reduced|nmod|START_ENTITY reduced|nsubjpass|activity activity|amod|END_ENTITY Ornithine_decarboxylase activity as well as the concentration of internal polyamines were found to be reduced by 1,12-DD . 16519678 3 1,12-diaminododecane 561,581 PAO 478,481 1,12-diaminododecane PAO MESH:C016417 212503(Tax:10090) Chemical Gene 1,8-diaminooctane|dep|START_ENTITY analogues|xcomp|1,8-diaminooctane analogues|nsubj|study study|nmod|END_ENTITY Here , a comparative study on murine PAO -LRB- mPAO -RRB- and SMO -LRB- mSMO -RRB- inhibition by the polyamine analogues 1,8-diaminooctane , 1,12-diaminododecane , N-prenylagmatine -LRB- G3 -RRB- , guazatine and N,N1-bis -LRB- 2,3-butadienyl -RRB- -1,4 - butanediamine -LRB- MDL72527 -RRB- is reported . 16519678 3 1,12-diaminododecane 561,581 SMO 493,496 1,12-diaminododecane SMO MESH:C016417 54498 Chemical Gene 1,8-diaminooctane|dep|START_ENTITY analogues|xcomp|1,8-diaminooctane analogues|nsubj|study study|nmod|PAO PAO|conj|END_ENTITY Here , a comparative study on murine PAO -LRB- mPAO -RRB- and SMO -LRB- mSMO -RRB- inhibition by the polyamine analogues 1,8-diaminooctane , 1,12-diaminododecane , N-prenylagmatine -LRB- G3 -RRB- , guazatine and N,N1-bis -LRB- 2,3-butadienyl -RRB- -1,4 - butanediamine -LRB- MDL72527 -RRB- is reported . 24881569 1 1,12-dicarba-closo-dodecaborane 162,193 fibronectin 353,364 1,12-dicarba-closo-dodecaborane fibronectin null 2335 Chemical Gene cluster|amod|START_ENTITY cluster|nmod|6-N 6-N|appos|activity activity|dep|C C|conj|adherence adherence|nmod|END_ENTITY An impact of adenosine modification with electroneutral , lipophilic 1,12-dicarba-closo-dodecaborane or electronegative 7,8-dicarba-nido-undecaborane boron cluster at the 6-N , 2 ' - C and 2-C positions on human neutrophil oxidative burst , neutrophil adherence to fibronectin and protein kinase C activity was studied . 17676909 5 1,12-dimethyl 975,988 C-7 1027,1030 1,12-dimethyl C-7 null 730 Chemical Gene observed|nmod|START_ENTITY observed|ccomp|carbocation carbocation|amod|protonated protonated|amod|END_ENTITY With 3,9-dimethyl -LRB- 14 -RRB- , C-7 protonation -LRB- 14H + -RRB- is strongly favored -LRB- with < 10 % protonation at C-12 -RRB- , and with 1,12-dimethyl -LRB- 15 -RRB- the sole species observed is the C-7 protonated carbocation -LRB- 15H + -RRB- . 17676909 5 1,12-dimethyl 975,988 C-7 890,893 1,12-dimethyl C-7 null 730 Chemical Gene observed|nmod|START_ENTITY favored|conj|observed favored|nsubj|protonation protonation|compound|END_ENTITY With 3,9-dimethyl -LRB- 14 -RRB- , C-7 protonation -LRB- 14H + -RRB- is strongly favored -LRB- with < 10 % protonation at C-12 -RRB- , and with 1,12-dimethyl -LRB- 15 -RRB- the sole species observed is the C-7 protonated carbocation -LRB- 15H + -RRB- . 7559809 2 1,12-dimethylspermine 392,413 SSAT 453,457 1,12-dimethylspermine SSAT MESH:C073195 6303 Chemical Gene analogue|appos|START_ENTITY produces|nsubj|analogue produces|dobj|induction induction|nmod|END_ENTITY We now report that one polyamine analogue , 1,12-dimethylspermine -LRB- DMSpm -RRB- , produces a large induction of SSAT with no significant effects on growth in the human large_cell_lung_carcinoma line , NCl H157 . 25305783 1 1,12-DoDDMA 286,297 TERP 463,467 1,12-DoDDMA TERP null 55825 Chemical Gene dimethacrylate|dep|START_ENTITY i.e.|appos|dimethacrylate based|nmod|i.e. liquid|acl:relcl|based synthesized|nsubjpass|liquid synthesized|xcomp|using using|dobj|polymerization polymerization|appos|END_ENTITY New monolithic reversed-phase liquid chromatography -LRB- RPLC -RRB- stationary phases based on single multi-acrylate/methacrylate-containing monomers -LSB- i.e. , 1,12-dodecanediol _ dimethacrylate -LRB- 1,12-DoDDMA -RRB- , trimethylolpropane_trimethacrylate -LRB- TRIM -RRB- and pentaerythritol_tetraacrylate -LRB- PETA -RRB- -RSB- were synthesized using organotellurium-mediated living radical polymerization -LRB- TERP -RRB- , which was expected to produce more efficient monolithic columns than conventional free-radical polymerization . 23122321 4 1,12-dodecanediamine 788,808 C10 704,707 1,12-dodecanediamine C10 MESH:C016417 3226 Chemical Gene residues|amod|START_ENTITY derived|nmod|residues amide-diamines|acl|derived polyamides|conj|amide-diamines polyamides|acl|derived derived|nmod|END_ENTITY Furthermore , polyamides -LRB- PAs -RRB- derived from C10 and C14 dicarboxylic_acids and amide-diamines derived from 1,6-hexanediamine or 1,12-dodecanediamine and L-phenylalanine , L-valyl-L-phenylalanine or L-phenylalanyl-L-valine residues have been reported as biocompatible polymers . 26335988 4 1,12-dodecanediol 958,975 APE1 905,909 1,12-dodecanediol APE1 null 328 Chemical Gene loop|amod|START_ENTITY using|nmod|loop distinguish|advcl|using distinguish|nmod|activity activity|nmod|END_ENTITY In the present study we demonstrate a highly specific real-time detection of the AP-site cleaving activity of Tdp1 which allows one to distinguish it from the activity of APE1 by using a short hairpin oligonucleotide with a 1,12-dodecanediol loop , a 5 ' - fluorophore and a 3 ' - quencher . 26335988 4 1,12-dodecanediol 958,975 Tdp1 844,848 1,12-dodecanediol Tdp1 null 55775 Chemical Gene loop|amod|START_ENTITY using|nmod|loop distinguish|advcl|using allows|xcomp|distinguish END_ENTITY|acl:relcl|allows In the present study we demonstrate a highly specific real-time detection of the AP-site cleaving activity of Tdp1 which allows one to distinguish it from the activity of APE1 by using a short hairpin oligonucleotide with a 1,12-dodecanediol loop , a 5 ' - fluorophore and a 3 ' - quencher . 7150629 5 1,1-2H2 992,999 C-2 818,821 1,1-2H2 C-2 null 24231(Tax:10116) Chemical Gene administration|nummod|START_ENTITY -LSB-|dobj|administration h|acl|-LSB- 2.7-4|nmod|h 2.7-4|nsubj|content content|nmod|END_ENTITY The total deuterium content at C-2 and C-3 of the glycerol moiety of 1-alkyl-2-acyl - _ and_1-alk-1 ' - enyl-2-acyl-sn-glycero-3-phosphocholines was 2.7-4 .4 atom % and 0.3-0 .8 atom % , respectively , after 48 h of -LSB- 1,1-2H2 -RSB- ethanol administration . 7150629 5 1,1-2H2 992,999 C-3 826,829 1,1-2H2 C-3 null 24232(Tax:10116) Chemical Gene administration|nummod|START_ENTITY -LSB-|dobj|administration h|acl|-LSB- 2.7-4|nmod|h 2.7-4|nsubj|content content|nmod|C-2 C-2|conj|END_ENTITY The total deuterium content at C-2 and C-3 of the glycerol moiety of 1-alkyl-2-acyl - _ and_1-alk-1 ' - enyl-2-acyl-sn-glycero-3-phosphocholines was 2.7-4 .4 atom % and 0.3-0 .8 atom % , respectively , after 48 h of -LSB- 1,1-2H2 -RSB- ethanol administration . 3988004 1 1,1,2-TCE 150,159 cytochrome_P-450 165,181 1,1,2-TCE cytochrome P-450 null 25251(Tax:10116) Chemical Gene START_ENTITY|nmod|END_ENTITY The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital . 3988004 1 1,1,2-TCE 150,159 cytochrome_P-450 261,277 1,1,2-TCE cytochrome P-450 null 25251(Tax:10116) Chemical Gene 1,1,1-trichloroethane|conj|START_ENTITY interactions|nmod|1,1,1-trichloroethane observed|nsubjpass|interactions observed|xcomp|using using|xcomp|measure measure|dobj|changes changes|nmod|END_ENTITY The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital . 3988004 4 1,1,2-TCE 758,767 cytochrome_P-450 688,704 1,1,2-TCE cytochrome P-450 null 25251(Tax:10116) Chemical Gene metabolized|advcl|START_ENTITY seemed|xcomp|metabolized bound|conj|seemed bound|nmod|END_ENTITY However , 1,1,1-TCE bound more tightly to cytochrome_P-450 and seemed to be only slowly metabolized compared to 1,1,2-TCE . 3389679 2 1,1,2-TCE 759,768 GGT 895,898 1,1,2-TCE GGT null 116568(Tax:10116) Chemical Gene 1,1,2-trichloroethane|dep|START_ENTITY initiation|conj|1,1,2-trichloroethane administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels . 3389679 3 1,1,2-TCE 951,960 GGT 999,1002 1,1,2-TCE GGT null 116568(Tax:10116) Chemical Gene 1,1,2,2-TTCE|conj|START_ENTITY 1,1,2,2-TTCE|dep|increases increases|nmod|+ +|compound|END_ENTITY 1,1,2,2-TTCE , TTCY , and 1,1,2-TCE also induced significant increases in GGT + - foci when administered in the promotion protocol without DEN initiation . 4064948 1 1,1,2-trichloroethane 151,172 CD-1 194,198 1,1,2-trichloroethane CD-1 MESH:C024567 111334(Tax:10090) Chemical Gene effects|nmod|START_ENTITY assess|dobj|effects assess|nmod|mice mice|compound|END_ENTITY The purpose of this study was to assess the immunological effects of 1,1,2-trichloroethane -LRB- TCE -RRB- on random-bred CD-1 mice following 14 and 90 days of oral exposure . 7285278 4 1,1,2-trichloroethane 755,776 cytochrome_P-450 706,722 1,1,2-trichloroethane cytochrome P-450 MESH:C024567 4051 Chemical Gene metabolites|acl|START_ENTITY mono|nsubj|metabolites converted|advcl|mono converted|xcomp|2,2,2-trichloroethanol 2,2,2-trichloroethanol|nmod|END_ENTITY 1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively . 3389679 2 1,1,2-trichloroethane 736,757 GGT 895,898 1,1,2-trichloroethane GGT MESH:C024567 116568(Tax:10116) Chemical Gene initiation|conj|START_ENTITY administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels . 4064947 1 1,1,2-Trichloroethane 50,71 CD-1 114,118 1,1,2-Trichloroethane CD-1 MESH:C024567 111334(Tax:10090) Chemical Gene administered|nsubjpass|START_ENTITY administered|nmod|mice mice|compound|END_ENTITY 1,1,2-Trichloroethane -LRB- TCE -RRB- was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters . 19005803 2 1,1,2-trichlorotrifluoroethane 503,533 R12 494,497 1,1,2-trichlorotrifluoroethane R12 null 2840 Chemical Gene trichlorofluoromethane|conj|START_ENTITY trichlorofluoromethane|conj|dichlorodifluoromethane dichlorodifluoromethane|dep|END_ENTITY Fully halogenated VCCs -LRB- tetrachloroethylene , 1,1,1-trichloroethane , tetrachloromethane and dichloromethane -RRB- and CFCs -LRB- trichlorofluoromethane -LRB- R11 -RRB- , dichlorodifluoromethane -LRB- R12 -RRB- and 1,1,2-trichlorotrifluoroethane -LRB- R113 -RRB- -RRB- were degraded under anaerobic conditions in addition to the methanogenic bacteria in municipal solid waste -LRB- MSW -RRB- and organic wastes . 3016262 0 1,1,2-triphenylbut-1-ene 26,50 estradiol_receptor 89,107 1,1,2-triphenylbut-1-ene estradiol receptor MESH:C035804 13982(Tax:10090) Chemical Gene type|amod|START_ENTITY estrogens|nmod|type estrogens|dep|relationship relationship|nmod|structure structure|conj|affinity affinity|compound|END_ENTITY Catechol estrogens of the 1,1,2-triphenylbut-1-ene type : relationship between structure , estradiol_receptor affinity , estrogenic and antiestrogenic properties , and mammary_tumor inhibiting activities . 6813499 0 1,1,2-triphenylbut-1-enes 0,25 estradiol_receptor 59,77 1,1,2-triphenylbut-1-enes estradiol receptor null 2099 Chemical Gene START_ENTITY|dep|relationship relationship|nmod|structure structure|conj|affinity affinity|compound|END_ENTITY 1,1,2-triphenylbut-1-enes : relationship between structure , estradiol_receptor affinity , and mammary_tumor inhibiting properties . 4068009 1 1,1,2-Triphenylbut-1-enes 107,132 Z-10-12 141,148 1,1,2-Triphenylbut-1-enes Z-10-12 null 958016(Tax:155864) Chemical Gene START_ENTITY|dep|- -|conj|END_ENTITY 1,1,2-Triphenylbut-1-enes -LRB- E - and Z-10-12 -RRB- , which are substituted with one p - and one m-acetoxy group in two different aromatic rings , were synthesized . 23186146 6 1,1,2-triphenylethane 1141,1162 Ph3E 1164,1168 1,1,2-triphenylethane Ph3E null 10338 Chemical Gene END_ENTITY|amod|START_ENTITY Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis . 17084061 0 1,1,2-Tris-organoselenide 0,25 delta-aminolevulinate_dehydratase 107,140 1,1,2-Tris-organoselenide delta-aminolevulinate dehydratase null 210 Chemical Gene derivatives|amod|START_ENTITY inhibited|nsubj|derivatives inhibited|dobj|activity activity|amod|END_ENTITY 1,1,2-Tris-organoselenide alkene derivatives , but not 1,2-bis-organoselenide alkene derivatives , inhibited delta-aminolevulinate_dehydratase activity from human erythrocytic cells in vitro . 1334553 6 11305-11309 543,554 Fc_gamma_RI 598,609 11305-11309 Fc gamma RI MESH:C038213 2209 Chemical Gene USA|nummod|START_ENTITY -RSB-|dep|USA defined|dep|-RSB- defined|nmod|region region|nmod|gene gene|compound|END_ENTITY USA 88 , 11305-11309 -RSB- defined within the promoter region of the Fc_gamma_RI gene an element , the gamma response region , which was necessary for IFN-gamma-induced enhancement of Fc_gamma_RI . 1334553 6 11305-11309 543,554 Fc_gamma_RI 711,722 11305-11309 Fc gamma RI MESH:C038213 2209 Chemical Gene USA|nummod|START_ENTITY -RSB-|dep|USA defined|dep|-RSB- defined|nsubj|element element|appos|region region|acl:relcl|necessary necessary|nmod|enhancement enhancement|nmod|END_ENTITY USA 88 , 11305-11309 -RSB- defined within the promoter region of the Fc_gamma_RI gene an element , the gamma response region , which was necessary for IFN-gamma-induced enhancement of Fc_gamma_RI . 21255402 9 11-32A 1317,1323 CC1690 1306,1312 11-32A CC1690 null 942045(Tax:190650) Chemical Gene END_ENTITY|conj|START_ENTITY Comparison of oil content in five common laboratory strains -LRB- CC124 , CC125 , cw15 , CC1690 and 11-32A -RRB- revealed a high variability , from 2 g TAG per million cell in CC124 to 11 g in 11-32A . 19631550 1 1,1,3,3-tetramethoxypropane 213,240 cis-4 250,255 1,1,3,3-tetramethoxypropane cis-4 MESH:C041295 9306 Chemical Gene dimercapto-succinate|conj|START_ENTITY -2,3|amod|dimercapto-succinate transacetalation|nmod|-2,3 provided|nsubj|transacetalation provided|dobj|,5 ,5|amod|END_ENTITY Acid-catalyzed transacetalation of dimethyl _ -LRB- 2R ,3 S -RRB- -2,3 - dimercapto-succinate and 1,1,3,3-tetramethoxypropane provided cis-4 ,5 - dimethoxycarbonyl-2 - -LRB- 2 ' ,2 ' - dimethoxyethyl -RRB- -1,3 - dithiolane -LRB- 2 -RRB- in 77 % yield . 12809941 3 1,1,3,3-tetramethyl-2-thiourea 530,560 IL-8 399,403 1,1,3,3-tetramethyl-2-thiourea IL-8 null 3576 Chemical Gene N-acetyl-L-cysteine|conj|START_ENTITY antioxidants|amod|N-acetyl-L-cysteine effect|nmod|antioxidants evaluated|nsubjpass|effect determined|conj|evaluated determined|nsubjpass|induction induction|compound|END_ENTITY IL-8 induction and secretion were determined in the presence of the toxics , and the effect of antioxidants N-acetyl-L-cysteine and 1,1,3,3-tetramethyl-2-thiourea was evaluated . 9668065 10 1,1,3,3-tetramethyl-2-thiourea 1809,1839 PAF-R 2076,2081 1,1,3,3-tetramethyl-2-thiourea PAF-R null 5724 Chemical Gene N-acetyl_cysteine|amod|START_ENTITY inhibited|nsubj|N-acetyl_cysteine inhibited|advcl|suggesting suggesting|ccomp|stimulates stimulates|nmod|activity activity|amod|END_ENTITY The antioxidants N-acetyl_cysteine , 1,1,3,3-tetramethyl-2-thiourea , and vitamin_E inhibited both UVB-induced PAF biosynthesis as well as the augmentation of UVB-induced apoptosis in PAF-R-expressing KB clones , suggesting the possibility that UVB stimulates the production of oxidized lipid species with PAF-R agonistic activity in this model system . 19277394 1 1,1,3,3-tetramethyldisiloxane 173,202 PPh3 161,165 1,1,3,3-tetramethyldisiloxane PPh3 null 857 Chemical Gene 2|nmod|START_ENTITY IrCl|dep|2 IrCl|appos|END_ENTITY The combination of IrCl -LRB- CO -RRB- -LRB- PPh3 -RRB- 2 with 1,1,3,3-tetramethyldisiloxane or poly -LRB- methylhydrosiloxane -RRB- -LRB- PMHS -RRB- is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides ; in particular , facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS . 24768890 4 1,1,3,3-tetramethylguanidine 485,513 CO2 705,708 1,1,3,3-tetramethylguanidine CO2 MESH:C477069 717 Chemical Gene START_ENTITY|acl|based based|ccomp|synthesized synthesized|nmod|tetrafluoroborate tetrafluoroborate|dep|used used|nmod|absorption absorption|nmod|SO2 SO2|conj|END_ENTITY 1,1,3,3-tetramethylguanidine -LRB- TMG -RRB- - based ILs , including 1,1,3,3-tetramethylguanidine tetrafluoroborate -LRB- -LSB- TMG -RSB- -LSB- BF4 -RSB- -RRB- and 1,1,3,3-tetramethylguanidine _ lactate -LRB- -LSB- TMG -RSB- L -RRB- which were commonly used in the absorption of SO2 and CO2 from flue gas , were synthesized and applied in the conversion of MCC to 5-HMF for the first time . 24768890 4 1,1,3,3-tetramethylguanidine 541,569 CO2 705,708 1,1,3,3-tetramethylguanidine CO2 MESH:C477069 717 Chemical Gene tetrafluoroborate|amod|START_ENTITY tetrafluoroborate|dep|used used|nmod|absorption absorption|nmod|SO2 SO2|conj|END_ENTITY 1,1,3,3-tetramethylguanidine -LRB- TMG -RRB- - based ILs , including 1,1,3,3-tetramethylguanidine tetrafluoroborate -LRB- -LSB- TMG -RSB- -LSB- BF4 -RSB- -RRB- and 1,1,3,3-tetramethylguanidine _ lactate -LRB- -LSB- TMG -RSB- L -RRB- which were commonly used in the absorption of SO2 and CO2 from flue gas , were synthesized and applied in the conversion of MCC to 5-HMF for the first time . 28464505 2 1,1,3,3-tetramethylguanidine 487,515 CO2 349,352 1,1,3,3-tetramethylguanidine CO2 MESH:C477069 717 Chemical Gene Ag2O/TMG|dep|START_ENTITY promoted|nmod|Ag2O/TMG a-hydroxyl_ketones|acl|promoted amount|nmod|a-hydroxyl_ketones synthesis|nmod|amount developed|nmod|synthesis END_ENTITY|conj|developed Herein , a one-pot three-component reaction of terminal propargyl_alcohols , CO2 , and 2-aminoethanols was developed for the synthesis of 2-oxazolidinones and equal amount of a-hydroxyl_ketones promoted by Ag2O/TMG -LRB- 1,1,3,3-tetramethylguanidine -RRB- with the TON -LRB- turnover number -RRB- up to 1260 . 21619462 3 11365C 572,578 ADIPOQ 541,547 11365C ADIPOQ null 9370 Chemical Gene G|nummod|START_ENTITY rs266729|appos|G rs2241766|nsubj|rs266729 rs2241766|dep|Genotyping Genotyping|nmod|SNPs SNPs|nmod|gene gene|amod|END_ENTITY Genotyping of SNPs in the ADIPOQ gene , namely , rs266729 -LRB- 11365C > G -RRB- ; rs822395 -LRB- 4034A > C -RRB- ; rs822396 -LRB- 3964A > G -RRB- ; rs2241766 -LRB- +45 T > G -RRB- were performed . 9266215 1 1-13C 98,103 galactose-1-phosphate_uridyltransferase 212,251 1-13C galactose-1-phosphate uridyltransferase null 2592 Chemical Gene -RSB-|nummod|START_ENTITY _|nmod:npmod|-RSB- galactose|amod|_ employed|dobj|galactose employed|advcl|delineate delineate|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY We employed -LSB- 1-13C -RSB- _ galactose in isotope kinetic studies to delineate whole body galactose metabolism in vivo in patients with galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- deficiency . 9266215 1 1-13C 98,103 GALT 253,257 1-13C GALT null 2592 Chemical Gene -RSB-|nummod|START_ENTITY _|nmod:npmod|-RSB- galactose|amod|_ employed|dobj|galactose employed|advcl|delineate delineate|nmod|patients patients|nmod|deficiency deficiency|appos|END_ENTITY We employed -LSB- 1-13C -RSB- _ galactose in isotope kinetic studies to delineate whole body galactose metabolism in vivo in patients with galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- deficiency . 9266222 8 1-13C_butyric_and_1-13C_octanoic_acids 1151,1189 MADM 1120,1124 1-13C butyric and 1-13C octanoic acids MADM null 29959 Chemical Gene oxidation|nmod|START_ENTITY normal|nsubj|oxidation normal|nmod|patient patient|compound|END_ENTITY In the MADM patient , the oxidation of 1-13C_butyric_and_1-13C_octanoic_acids were normal , whereas the metabolism of 1-13C_palmitic_acid ranged from 33 % of 66 % of controls . 8683583 10 113Cd 1234,1239 CYP1 1326,1330 113Cd CYP1 CHEBI:52620 850958(Tax:4932) Chemical Gene spectroscopy|amod|START_ENTITY 1H|conj|spectroscopy Using|dobj|1H undertaken|advcl|Using undertaken|dobj|analysis analysis|nmod|properties properties|nmod|fragment fragment|compound|END_ENTITY Using 1H , 15N and 113Cd NMR spectroscopy , we have undertaken the analysis of the structural properties of the CYP1 -LRB- 56-126 -RRB- fragment that consists of the zinc-cluster region , the linker peptide and a part of the dimerization helix . 2186803 5 113Cd 564,569 GAL4 715,719 113Cd GAL4 CHEBI:52620 855828(Tax:4932) Chemical Gene NMR|compound|START_ENTITY NMR|dep|GAL4 GAL4|acl:relcl|reveals reveals|dobj|identity identity|nmod|domains domains|nmod|GAL4 GAL4|conj|that that|nmod|END_ENTITY 113Cd NMR of 113Cd -LRB- II -RRB- - substituted GAL4 -LRB- 63 -RRB- reveals structural identity between the metal binding domains of GAL4 -LRB- 63 -RRB- and that of the larger precursor GAL4 -LRB- 149 -RRB- . 2186803 5 113Cd 577,582 GAL4 715,719 113Cd GAL4 CHEBI:52620 855828(Tax:4932) Chemical Gene NMR|nmod|START_ENTITY NMR|dep|GAL4 GAL4|acl:relcl|reveals reveals|dobj|identity identity|nmod|domains domains|nmod|GAL4 GAL4|conj|that that|nmod|END_ENTITY 113Cd NMR of 113Cd -LRB- II -RRB- - substituted GAL4 -LRB- 63 -RRB- reveals structural identity between the metal binding domains of GAL4 -LRB- 63 -RRB- and that of the larger precursor GAL4 -LRB- 149 -RRB- . 1936288 1 113Cd 230,235 glucocorticoid_receptor 278,301 113Cd glucocorticoid receptor CHEBI:52620 24413(Tax:10116) Chemical Gene domain|amod|START_ENTITY domain|nmod|END_ENTITY Two-dimensional 1H-113Cd HSQC and relay HSQC experiments were performed on the 113Cd substituted DNA binding domain of the rat glucocorticoid_receptor . 437098 0 113Cd 49,54 Mg2 0,3 113Cd Mg2 CHEBI:52620 4589 Chemical Gene 25Mg|conj|START_ENTITY spectroscopy|compound|25Mg studied|nmod|spectroscopy parvalbumins|acl|studied binding|nmod|parvalbumins +|xcomp|binding +|nsubj|END_ENTITY Mg2 + binding to parvalbumins studied by 25Mg and 113Cd NMR spectroscopy . 7056717 11 113Cd 1500,1505 MT-1 1533,1537 113Cd MT-1 CHEBI:52620 539948(Tax:9913) Chemical Gene spectrum|amod|START_ENTITY spectrum|nmod|END_ENTITY Three minor resonances to higher field are observed in the 113Cd NMR spectrum of calf liver MT-1 and one in calf liver MT-2 , which may be attributed to a small fraction of cluster B with one Cu + replaced by 113Cd2 + . 3681973 4 113Cd 944,949 MT2 954,957 113Cd MT2 CHEBI:52620 689415(Tax:10116) Chemical Gene preparations|nmod|START_ENTITY homogeneous|dobj|preparations homogeneous|parataxis|obtained obtained|nsubjpass|END_ENTITY Solutions of high-pressure liquid chromatographically homogeneous biosynthetic preparations of -LSB- 113Cd , Zn -RSB- MT2 were obtained from rat liver following injection of 113Cd into rats in vivo , without further metal exchange after protein isolation . 7056717 11 113Cd 1500,1505 MT-2 1560,1564 113Cd MT-2 CHEBI:52620 404070(Tax:9913) Chemical Gene spectrum|amod|START_ENTITY observed|nmod|spectrum observed|nmod|END_ENTITY Three minor resonances to higher field are observed in the 113Cd NMR spectrum of calf liver MT-1 and one in calf liver MT-2 , which may be attributed to a small fraction of cluster B with one Cu + replaced by 113Cd2 + . 8387280 0 113Cd-1H 14,22 retinoic_acid_receptor-beta 68,95 113Cd-1H retinoic acid receptor-beta null 5915 Chemical Gene study|amod|START_ENTITY study|nmod|coordination coordination|nmod|domain domain|compound|END_ENTITY Heteronuclear 113Cd-1H NMR study of metal coordination in the human retinoic_acid_receptor-beta DNA binding domain . 3681973 6 113Cd7 1437,1443 MT2 1444,1447 113Cd7 MT2 null 689415(Tax:10116) Chemical Gene END_ENTITY|compound|START_ENTITY For the components of the four-metal cluster , the major one of these different forms exhibits patterns in the two-dimensional -LSB- 1H , _ 113Cd -RSB- - correlated spectra that are indistinguishable from those of -LSB- 113Cd7 -RSB- MT2 , thereby implying identity of cluster coordination and topology . 9256239 2 113Cd-substituted_HDH 274,295 Cd2 322,325 113Cd-substituted HDH Cd2 null 914 Chemical Gene START_ENTITY|nmod|presence presence|nmod|END_ENTITY 113Cd-substituted_HDH in the presence of excess Cd2 + has been studied by 113Cd-NMR . 1657733 6 1-13C-ethanol 1128,1141 spin 1042,1046 1-13C-ethanol spin null 361217(Tax:10116) Chemical Gene adduct|amod|START_ENTITY those|nmod|adduct lines|nmod|those indicated|nmod|lines adduct|acl:relcl|indicated adduct|compound|END_ENTITY Liver extracts also contained low concentrations of the 1-hydroxyethyl radical spin adduct , which was indicated by weak spectral lines corresponding to those of the 1-13C-ethanol adduct . 8960831 4 1-13C-glucose 964,977 insulin 1038,1045 1-13C-glucose insulin null 3630 Chemical Gene clamp|nmod|START_ENTITY quantitate|nsubj|clamp quantitate|dobj|action action|compound|END_ENTITY The euglycaemic hyperinsulinaemic clamp with 1-13C-glucose -LRB- Hot Ginf -RRB- and indirect calorimetry were used to quantitate insulin action and the hyperglycaemic clamp used to assess beta-cell function . 9266217 5 1-13C_leucine 642,655 CO2 757,760 1-13C leucine CO2 null 717 Chemical Gene technique|amod|START_ENTITY model|nsubj|technique model|acl|requiring requiring|dobj|estimation estimation|nmod|production production|compound|END_ENTITY The 1-13C_leucine technique is the most widely used and best validated model to date , requiring accurate estimation of CO2 production . 1690064 0 1-13C-leucine 34,47 apolipoprotein_B 51,67 1-13C-leucine apolipoprotein B null 338 Chemical Gene 15N-glycine|conj|START_ENTITY Incorporation|acl|15N-glycine Incorporation|nmod|END_ENTITY -LSB- Incorporation of 15N-glycine and 1-13C-leucine in apolipoprotein_B of VLDL and LDL in vivo in healthy probands -RSB- . 1430077 12 1-13C-leucine 1163,1176 IGF-I 1232,1237 1-13C-leucine IGF-I null 3479 Chemical Gene technique|amod|START_ENTITY flux|appos|technique decreased|nsubj|flux decreased|nmod|doses doses|nmod|END_ENTITY Whole body leucine flux -LRB- 1-13C-leucine infusion technique -RRB- decreased with increasing doses of IGF-I by 41 % during 30 micrograms/kg . 21429235 4 113C-Leucine 620,632 surfactant_protein-B 649,669 113C-Leucine surfactant protein-B null 6439 Chemical Gene disaturated-phosphatidylcholine-palmitate|conj|START_ENTITY disaturated-phosphatidylcholine-palmitate|dep|administered administered|nsubjpass|precursor precursor|nmod|END_ENTITY METHODS : 2H2O as precursor of disaturated-phosphatidylcholine-palmitate and 113C-Leucine as precursor of surfactant_protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls . 18543754 2 1-13-corticotropine 233,252 alpha-MSH 368,377 1-13-corticotropine alpha-MSH null 24664(Tax:10116) Chemical Gene components|amod|START_ENTITY consists|nmod|components called|ccomp|consists called|nsubj|effects effects|amod|Met-enkephalin Met-enkephalin|conj|END_ENTITY It consists of two peptide components : met-enkephalin and alpha 1-13-corticotropine -LRB- alpha-ACTH 1-13 -RRB- , previously called alpha-melanocyte-stimulating hormone-like -LRB- alpha-MSH-like -RRB- Met-enkephalin and alpha-MSH exhibited cytoprotective effects individually and statistically significant additive effect was registered when both peptides were applied in combination on the model of ethanol induced gastric_lesions in rats . 9266222 6 1-13C_palmitic_acid 926,945 MADM 839,843 1-13C palmitic acid MADM null 29959 Chemical Gene utilization|nmod|START_ENTITY therapy|nmod|utilization influence|nmod|therapy examined|nsubjpass|influence examined|nmod|patient patient|compound|END_ENTITY In the MADM patient the influence of carnitine therapy -LRB- or deprivation -RRB- on the utilization of 1-13C_palmitic_acid was also examined . 9266222 8 1-13C_palmitic_acid 1229,1248 MADM 1120,1124 1-13C palmitic acid MADM null 29959 Chemical Gene metabolism|nmod|START_ENTITY ranged|nsubj|metabolism normal|advcl|ranged normal|nmod|patient patient|compound|END_ENTITY In the MADM patient , the oxidation of 1-13C_butyric_and_1-13C_octanoic_acids were normal , whereas the metabolism of 1-13C_palmitic_acid ranged from 33 % of 66 % of controls . 11597790 2 113His 435,441 EPHX1 384,389 113His EPHX1 null 2052 Chemical Gene 113Tyr|dep|START_ENTITY region|conj|113Tyr region|nmod|gene gene|appos|END_ENTITY Two polymorphisms have been described in the coding region of the mEH gene -LRB- EPHX1 -RRB- that produce two protein variants : 113Tyr -- > 113His -LRB- exon 3 -RRB- and 139His -- > 139Arg -LRB- exon 4 -RRB- . 11597790 2 113His 435,441 mEH 374,377 113His mEH null 13849(Tax:10090) Chemical Gene 113Tyr|dep|START_ENTITY region|conj|113Tyr region|nmod|gene gene|compound|END_ENTITY Two polymorphisms have been described in the coding region of the mEH gene -LRB- EPHX1 -RRB- that produce two protein variants : 113Tyr -- > 113His -LRB- exon 3 -RRB- and 139His -- > 139Arg -LRB- exon 4 -RRB- . 7430349 9 113In 837,842 transferrin 843,854 113In transferrin null 7018 Chemical Gene END_ENTITY|amod|START_ENTITY Plasma clearance of -LSB- 113In -RSB- transferrin occurred with a T1/2 = 7.0 + / - 2.6 h -LRB- mean + / - SD -RRB- . 2668738 2 113-kilodalton 319,333 KEX1 380,384 113-kilodalton KEX1 MESH:C083025 852670(Tax:4932) Chemical Gene protein|amod|START_ENTITY protein|acl:relcl|absent absent|dep|disrupted disrupted|nsubjpass|gene gene|compound|END_ENTITY Anti-Kex1p antibodies identified a 113-kilodalton protein that was absent in cells in which the KEX1 gene has been disrupted and that was more abundant in cells overexpressing the KEX1 gene . 2298374 7 113mIn 1109,1115 transferrin 1117,1128 113mIn transferrin null 100009267(Tax:9986) Chemical Gene END_ENTITY|amod|START_ENTITY Uncorrected or simple brain uptake indices of -LSB- 3H -RSB- _ gamma-aminobutyric_acid and -LSB- 113mIn -RSB- transferrin were calculated using -LSB- 14C -RSB- _ butanol as the highly extracted reference compound . 11108834 1 1-13_nucleotides 292,308 DNA_polymerase_delta 136,156 1-13 nucleotides DNA polymerase delta MESH:D009711 5424 Chemical Gene gaps|nmod|START_ENTITY containing|dobj|gaps duplexes|acl|containing Misgurnus|nmod|duplexes Misgurnus|nsubj|interaction interaction|nmod|END_ENTITY We studied the interaction of DNA_polymerase_delta -LRB- pol delta -RRB- purified from the eggs of the teleost fish Misgurnus fossilis -LRB- loach -RRB- with DNA duplexes containing single-stranded gaps of 1-13_nucleotides -LRB- nt -RRB- . 625587 1 1,1,3-tricyano-2-amino-1-propene 117,149 CNP 266,269 1,1,3-tricyano-2-amino-1-propene CNP MESH:C025201 395921(Tax:9031) Chemical Gene Injections|nmod|START_ENTITY increases|nsubj|Injections increases|ccomp|enzyme enzyme|dobj|phosphohydrolase phosphohydrolase|appos|END_ENTITY Injections of 1,1,3-tricyano-2-amino-1-propene -LRB- TCAP -RRB- into chick embryos increases the synthesis of the myelin enzyme 2 ' ,3 ' - cyclic nucleotide 3 ' - phosphohydrolase -LRB- CNP -RRB- . 20534649 5 1-140 1045,1050 alpha-synuclein 1029,1044 1-140 alpha-synuclein MESH:C065679 6622 Chemical Gene END_ENTITY|appos|START_ENTITY Furthermore , the release of FM1-43 dye from PC12 cells expressing either human full-length alpha-synuclein -LRB- 1-140 -RRB- or truncated alpha-synuclein -LRB- 1-120 -RRB- was reduced . 20534649 5 1-140 1045,1050 alpha-synuclein 1065,1080 1-140 alpha-synuclein MESH:C065679 20617(Tax:10090) Chemical Gene alpha-synuclein|appos|START_ENTITY END_ENTITY|conj|alpha-synuclein Furthermore , the release of FM1-43 dye from PC12 cells expressing either human full-length alpha-synuclein -LRB- 1-140 -RRB- or truncated alpha-synuclein -LRB- 1-120 -RRB- was reduced . 17002294 4 1-140 865,870 MDM2 837,841 1-140 MDM2 MESH:C065679 4193 Chemical Gene 31|appos|START_ENTITY 31|amod|peptides peptides|nmod|END_ENTITY The affinities of the chimeric peptides to MDM2 -LRB- 25-117 -RRB- and hTAF -LRB- II -RRB- 31 -LRB- 1-140 -RRB- were determined . 17426819 1 114-166_glycopeptide 172,192 erythropoietin 237,251 114-166 glycopeptide erythropoietin MESH:D006020 2056 Chemical Gene EPO|nummod|START_ENTITY synthesis|nmod|EPO described|nsubjpass|synthesis described|advcl|presenting presenting|dobj|glycophorin glycophorin|nmod|END_ENTITY A synthesis of EPO 114-166_glycopeptide -LRB- 1 -RRB- , presenting the O-linked glycophorin of erythropoietin , is described . 7782288 3 1141_amino_acid 680,695 cGI-PDE 671,678 1141 amino acid cGI-PDE null 5139 Chemical Gene END_ENTITY|appos|START_ENTITY The nucleotide sequence of its open reading frame was virtually identical to a corresponding region in the 3 ' portion of the cardiac cGIP2 cDNA -LRB- approximately 7.6 kb -RRB- which encoded a approximately 125-kDa cGI-PDE -LRB- 1141_amino_acid -RRB- . 12462625 5 1141-SO3H 748,757 MS3 706,709 1141-SO3H MS3 null 100271695 Chemical Gene -RSB-|nummod|START_ENTITY gave|dobj|-RSB- gave|nsubj|MS-MS MS-MS|conj|END_ENTITY MS-MS and MS3 gave major fragment ions at m/z 1061 -LSB- 1141-SO3H -RSB- - and m/z 945 -LSB- 1061-C9H12O -RSB- - . 9131949 1 114297A 185,192 beta_2-adrenoceptor 153,172 114297A beta 2-adrenoceptor null 154 Chemical Gene GR|nummod|START_ENTITY R-enantiomer|nsubj|GR agonist|dep|R-enantiomer agonist|amod|END_ENTITY AIMS : The new potent and selective beta_2-adrenoceptor agonist , GR 114297A -LRB- picumeterol -RRB- is the R-enantiomer of the racemic form , GR_63411B . 20688124 8 1,1,4,4-TetraCBD 1358,1374 HPRT 1476,1480 1,1,4,4-TetraCBD HPRT null 3251 Chemical Gene recommended|nmod|START_ENTITY recommended|xcomp|perform perform|dobj|test test|appos|test test|amod|END_ENTITY For the main component 1,1,4,4-TetraCBD , which is negative in the Ames , it is recommended to perform a third in vitro genotoxicity test , the HPRT test , before it can be decided whether to refer to the guideline value of HexaCBD at 600 ng/L or still to use the conservative TTC-based target value of 75 ng/L . 11283007 1 1145-amino_acid_DEXH 116,136 PRP22 95,100 1145-amino acid DEXH PRP22 MESH:C456319 856732(Tax:4932) Chemical Gene helicase|amod|START_ENTITY encodes|dobj|helicase encodes|nsubj|gene gene|compound|END_ENTITY The essential Saccharomyces_cerevisiae PRP22 gene encodes a 1145-amino_acid_DEXH box RNA helicase . 19825998 5 1-146 776,781 apoA-V 769,775 1-146 apoA-V MESH:D051929 116519 Chemical Gene segments|appos|START_ENTITY segments|amod|END_ENTITY Fourier transformed infrared spectroscopy analysis revealed that apoA-V -LRB- 1-146 -RRB- alpha-helix segments align perpendicular with respect to particle phospholipid fatty acyl chains . 19825998 7 1-146 1071,1076 apoA-V 1064,1070 1-146 apoA-V MESH:D051929 116519 Chemical Gene alpha-helices|appos|START_ENTITY alpha-helices|amod|END_ENTITY The data are consistent with a model wherein apoA-V -LRB- 1-146 -RRB- alpha-helices circumscribe the perimeter of a disk-shaped bilayer . 21335450 0 11478G 9,15 SERPINA1 0,8 11478G SERPINA1 MESH:C420352 5265 Chemical Gene START_ENTITY|compound|END_ENTITY SERPINA1 11478G _ > _ A variant , serum a1-antitrypsin , exacerbation frequency and FEV1 decline in COPD . 21193293 3 11482G 630,636 insulin 657,664 11482G insulin MESH:C420352 3630 Chemical Gene PLIN1|nummod|START_ENTITY interaction|nmod|PLIN1 __|nsubj|interaction __|dobj|A A|nmod|resistance resistance|compound|END_ENTITY METHODS AND RESULTS : We investigated the previously shown interaction for PLIN1 11482G __ > __ A -LRB- rs894160 -RRB- on insulin resistance in US men -LRB- n = 462 -RRB- and women -LRB- n = 508 -RRB- -LRB- mean SD , 49 16 years -RRB- . 21193293 4 11482G 927,933 insulin 985,992 11482G insulin MESH:C420352 3630 Chemical Gene intake|conj|START_ENTITY carbohydrate|dobj|intake carbohydrate|nmod|HOMA-IR HOMA-IR|dep|assessment assessment|nmod|resistance resistance|compound|END_ENTITY In multivariable linear regression models , we found an interaction -LRB- P < 0.05 -RRB- between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN1 11482G __ > __ A for HOMA-IR -LRB- homeostasis model assessment of insulin resistance -RRB- in women . 15770500 2 11482G 378,384 perilipin 330,339 11482G perilipin MESH:C420352 5346 Chemical Gene A|nummod|START_ENTITY T|conj|A locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 18326614 2 11482G 416,422 perilipin 367,376 11482G perilipin MESH:C420352 5346 Chemical Gene PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|compound|END_ENTITY OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations . 15770500 2 11482G 378,384 PLIN 341,345 11482G PLIN MESH:C420352 5346 Chemical Gene A|nummod|START_ENTITY T|conj|A locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|perilipin perilipin|appos|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 15770500 2 11482G 378,384 PLIN 354,358 11482G PLIN MESH:C420352 5346 Chemical Gene A|nummod|START_ENTITY T|conj|A T|compound|END_ENTITY We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk . 18326614 2 11482G 416,422 PLIN 378,382 11482G PLIN MESH:C420352 5346 Chemical Gene PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|appos|END_ENTITY OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations . 18326614 2 11482G 416,422 PLIN1 391,396 11482G PLIN1 MESH:C420352 5346 Chemical Gene PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|dep|END_ENTITY OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations . 21193293 3 11482G 630,636 PLIN1 624,629 11482G PLIN1 MESH:C420352 5346 Chemical Gene END_ENTITY|nummod|START_ENTITY METHODS AND RESULTS : We investigated the previously shown interaction for PLIN1 11482G __ > __ A -LRB- rs894160 -RRB- on insulin resistance in US men -LRB- n = 462 -RRB- and women -LRB- n = 508 -RRB- -LRB- mean SD , 49 16 years -RRB- . 21193293 4 11482G 927,933 PLIN1 921,926 11482G PLIN1 MESH:C420352 5346 Chemical Gene START_ENTITY|compound|END_ENTITY In multivariable linear regression models , we found an interaction -LRB- P < 0.05 -RRB- between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN1 11482G __ > __ A for HOMA-IR -LRB- homeostasis model assessment of insulin resistance -RRB- in women . 18326614 2 11482G 416,422 PLIN4 409,414 11482G PLIN4 MESH:C420352 729359 Chemical Gene END_ENTITY|amod|START_ENTITY OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations . 18326614 2 11482G 416,422 PLIN5 428,433 11482G PLIN5 MESH:C420352 440503 Chemical Gene PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|conj|END_ENTITY OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations . 23649624 1 114-amino_acid 152,166 IL-15 142,147 114-amino acid IL-15 MESH:C087595 3600 Chemical Gene cytokine|amod|START_ENTITY Interleukin-15|appos|cytokine Interleukin-15|appos|END_ENTITY Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets . 23649624 1 114-amino_acid 152,166 IL-2 187,191 114-amino acid IL-2 MESH:C087595 3558 Chemical Gene cytokine|amod|START_ENTITY cytokine|acl|related related|nmod|END_ENTITY Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets . 23649624 1 114-amino_acid 152,166 Interleukin-15 126,140 114-amino acid Interleukin-15 MESH:C087595 3600 Chemical Gene cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets . 8622698 5 114-amino-acid 882,896 CBF1 844,848 114-amino-acid CBF1 null 19664(Tax:10090) Chemical Gene region|amod|START_ENTITY contains|nsubj|region demonstrated|ccomp|contains demonstrated|nsubj|assays assays|acl|using using|dobj|segments segments|nmod|NotchIC NotchIC|conj|END_ENTITY Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction . 8622698 5 114-amino-acid 882,896 CBF1 934,938 114-amino-acid CBF1 null 19664(Tax:10090) Chemical Gene region|amod|START_ENTITY contains|nsubj|region contains|dobj|domain domain|compound|END_ENTITY Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction . 8622698 6 114-amino-acid 1111,1125 CBF1 1201,1205 114-amino-acid CBF1 null 3516 Chemical Gene segment|amod|START_ENTITY coprecipitated|nsubj|segment coprecipitated|nmod|END_ENTITY This result was confirmed in immunoprecipation assays in which the N-terminal 114-amino-acid segment of NotchIC , but not the ankyrin repeat region , coprecipitated with CBF1 . 9418891 8 114-amino-acid 1102,1116 COX7RP 1181,1187 114-amino-acid COX7RP null 9167 Chemical Gene protein|amod|START_ENTITY similar|nsubj|protein similar|nmod|VIIa VIIa|appos|END_ENTITY The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- . 9418891 8 114-amino-acid 1102,1116 cytochrome_c_oxidase_subunit_VII-related_protein 1189,1237 114-amino-acid cytochrome c oxidase subunit VII-related protein null 9167 Chemical Gene protein|amod|START_ENTITY similar|nsubj|protein similar|nmod|VIIa VIIa|appos|COX7RP COX7RP|appos|END_ENTITY The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- . 9418891 8 114-amino-acid 1102,1116 EB1 1088,1091 114-amino-acid EB1 null 9167 Chemical Gene protein|amod|START_ENTITY similar|nsubj|protein encodes|xcomp|similar encodes|nsubj|cDNA cDNA|acl|associated associated|nmod|END_ENTITY The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- . 7884911 5 114-amino-acid 793,807 SP1 822,825 114-amino-acid SP1 null 6667 Chemical Gene region|amod|START_ENTITY region|nmod|domain domain|compound|END_ENTITY We delineate a 114-amino-acid region of the SP1 glutamine-rich activation domain that when fused to the GAL4 DNA binding domain can support transcription activation by Tat . 2344442 8 1-14C 791,796 CO2 858,861 1-14C CO2 null 717 Chemical Gene %|nmod|START_ENTITY Less|nmod|% recovered|nsubjpass|Less recovered|nmod|END_ENTITY Less than 1 % of the 1-14C from the dodecylthioacetic_acid was recovered in respiratory CO2 and about 3 % of the 1-14C from nonylthioacetic_acid . 8633856 8 1-14C 1220,1225 CO2 1203,1206 1-14C CO2 null 717 Chemical Gene glucose|nummod|START_ENTITY -LSB-|dobj|glucose formed|advcl|-LSB- END_ENTITY|acl|formed The amount of CO2 formed from -LSB- 1-14C -RSB- glucose and acetate labeling patterns obtained with the other 14C precursors indicated that the Entner-Doudoroff , transketolase-transaldolase , and heterolactic pathways were not significant . 8998370 11 1-14C 1800,1805 delta_9_and_delta_5_desaturase 1944,1974 1-14C delta 9 and delta 5 desaturase null 3995;3992 Chemical Gene -RSB-|compound|START_ENTITY Conversion|nmod|-RSB- inhibited|nsubjpass|Conversion inhibited|nmod|ethanol ethanol|acl|treated treated|xcomp|suggesting suggesting|dobj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY Conversion of -LSB- 1-14C -RSB- palmitic to oleic_acid and eicosatrienoic to arachidonic_acid were inhibited in 400 mM ethanol treated cells suggesting an inhibition of delta_9_and_delta_5_desaturase activity . 8330014 6 1-14C 1047,1052 glucose-6-phosphate_dehydrogenase 944,977 1-14C glucose-6-phosphate dehydrogenase null 2539 Chemical Gene glucose|nummod|START_ENTITY oxidation|nmod|glucose glycogen|conj|oxidation glycogen|conj|activities activities|nmod|dehydrogenase dehydrogenase|amod|END_ENTITY These observations are consistent with the significantly lower content of glycogen , the increased activities of glucose-6-phosphate_dehydrogenase and 6-phosphogluconate dehydrogenase and the increased oxidation of -LSB- 1-14C -RSB- glucose relative to -LSB- 6-14C -RSB- _ glucose in the differentiated cells . 8650256 5 1-14C 741,746 PLA-2 721,726 1-14C PLA-2 null 5320 Chemical Gene oleic_acid|nummod|START_ENTITY END_ENTITY|nmod|oleic_acid We report here data that demonstrates how various cytokines exhibit a marked hydrolytic activity mediated through PLA-2 against both -LSB- 1-14C -RSB- oleic_acid - and -LSB- 1-14C -RSB- arachidonic_acid-labeled Escherichia_coli -LRB- micelle -RRB- substrates . 712202 2 1-14C-AA 542,550 CO2 460,463 1-14C-AA CO2 null 717 Chemical Gene incubated|nmod|START_ENTITY incubated|nmod|C C|dep|buffer buffer|appos|END_ENTITY Slices of rabbit and human renal_papilla were incubated in Krebs-Ringer HCO3 - buffer , 95 % O2-5 % CO2 , glucose 10 mM , HSA 4 gm/100 ml , for 30 min at 38 degrees C , with and without 1-14C-AA -LRB- 10 micrometer -RRB- . 8480350 8 1-14C_acetate 1149,1162 CO2 1300,1303 1-14C acetate CO2 null 717 Chemical Gene START_ENTITY|acl:relcl|suggests suggests|ccomp|reflected reflected|nmod|END_ENTITY There was no disappearance of tritiated_acetate from PCs or of 1-14C_acetate from platelet-free mixtures of plasma and Seto_sol , which suggests that the disappearance of 14C_acetate from PCs reflected oxidation to CO2 , which could leave PCs through the walls of the plastic container . 1904726 3 1-14C-acetate 576,589 C-1 539,542 1-14C-acetate C-1 null 3183 Chemical Gene END_ENTITY|conj|START_ENTITY Because the oxidation of pyruvate labelled in position C-1 but not of 2-14C-pyruvate and of 1-14C-acetate was enhanced , captopril most probably stimulated the pyruvate decarboxylation reaction . 9822550 11 1-14C-acetyl 1662,1674 COX-2 1642,1647 1-14C-acetyl COX-2 null 19225(Tax:10090) Chemical Gene -RSB-|amod|START_ENTITY reacted|nmod|-RSB- END_ENTITY|acl|reacted Tryptic digestion and peptide mapping of COX-2 reacted with -LSB- 1-14C-acetyl -RSB- -36 indicated that selective COX-2 inhibition by 36 also resulted in the acetylation of Ser516 . 9822550 11 1-14C-acetyl 1662,1674 COX-2 1704,1709 1-14C-acetyl COX-2 null 19225(Tax:10090) Chemical Gene -RSB-|amod|START_ENTITY reacted|nmod|-RSB- COX-2|acl|reacted digestion|nmod|COX-2 indicated|nsubj|digestion indicated|ccomp|resulted resulted|nsubj|inhibition inhibition|compound|END_ENTITY Tryptic digestion and peptide mapping of COX-2 reacted with -LSB- 1-14C-acetyl -RSB- -36 indicated that selective COX-2 inhibition by 36 also resulted in the acetylation of Ser516 . 6424180 1 1-14C-arachidonate 283,301 lipoxygenase 157,169 1-14C-arachidonate lipoxygenase null 100009114(Tax:9986) Chemical Gene homogenates|amod|START_ENTITY incubations|nmod|homogenates derived|nmod|incubations products|acl|derived separation|nmod|products studied|nmod|separation studied|nsubjpass|ability ability|acl|convert convert|dep|arachidonic_acid arachidonic_acid|nmod|products products|amod|END_ENTITY The ability of rabbit fetal membranes to convert arachidonic_acid to both lipoxygenase and cyclooxygenase products was studied by separation and identification of products derived from incubations of 1-14C-arachidonate with subcellular fractions obtained by differential centrifugation of tissue homogenates . 8741332 2 1-14Carachidonic_acid 335,356 PGD2 244,248 1-14Carachidonic acid PGD2 null 374110(Tax:9031) Chemical Gene labeling|nmod|START_ENTITY using|advcl|labeling evaluated|xcomp|using evaluated|nsubjpass|production production|nmod|END_ENTITY The production of PGD2 was evaluated using thin layer chromatography -LRB- TLC -RRB- after labeling the RPE cells with 1-14Carachidonic_acid -LRB- AA -RRB- and radioimmunoassay -LRB- RIA -RRB- . 16413734 4 1,14-carbonate 608,622 C-7 653,656 1,14-carbonate C-7 null 730 Chemical Gene moiety|amod|START_ENTITY presence|nmod|moiety nature|conj|presence nature|conj|substituent substituent|nmod|END_ENTITY Affinity resulted significantly affected by the nature of the isoserinic side chain , the presence of the 1,14-carbonate moiety and the substituent at C-7 , showing that the hydrophobicity of the drug is fundamental in the binding process . 4069292 4 1-14C-glucose 933,946 CO2 702,705 1-14C-glucose CO2 null 717 Chemical Gene found|advcl|START_ENTITY higher|advcl|found higher|nsubj|rate rate|nmod|production production|compound|END_ENTITY The rate of labeled CO2 production from 6-14C-glucose , 1,5-14C-citric _ acid and U-14C-glutamine was about 2 times higher in melanotic melanomas than in amelanotic one , while no significant differences among the three melanomas were found in respect to 1-14C-glucose and U-14C-glycerol-3-phosphate . 597516 1 1-14C-glucose 186,199 CO2 366,369 1-14C-glucose CO2 null 717 Chemical Gene metabolization|amod|START_ENTITY rate|nmod|metabolization studied|nmod|rate studied|conj|labelled labelled|nmod|cells cells|acl|assimilating assimilating|xcomp|incapable incapable|nmod|reassimilation reassimilation|nmod|END_ENTITY The effect of phosphorylation on glycolysis reactions was studied in respect with the rate of 1-14C-glucose metabolization and the composition of synthesized labelled products in isolated cells of assimilating millet leave tissues incapable to reassimilation of respiratory CO2 . 967015 1 1-14C-glucose 161,174 insulin 150,157 1-14C-glucose insulin null 3630 Chemical Gene conversion|amod|START_ENTITY END_ENTITY|nmod|conversion The effect of varying concentrations of insulin on 1-14C-glucose conversion to 14CO2 was measured in subcutaneous adipose tissue samples obtained from 16 obese human subjects -LRB- 10 nondiabetic , 6 diabetic -RRB- . 967015 4 1-14C-glucose 740,753 insulin 717,724 1-14C-glucose insulin null 3630 Chemical Gene oxidation|amod|START_ENTITY sensitivity|nmod|oxidation sensitivity|compound|END_ENTITY There was , over-all , a significant correlation between Kins and Kitt , indicating that insulin sensitivity of 1-14C-glucose oxidation by adipose tissue in vitro reflects the general state of sensitivity of glucose metabolism to insulin in vivo in obese human subjects . 967015 4 1-14C-glucose 740,753 insulin 858,865 1-14C-glucose insulin null 3630 Chemical Gene oxidation|amod|START_ENTITY sensitivity|nmod|oxidation indicating|dobj|sensitivity over-all|acl|indicating reflects|nsubj|over-all reflects|nmod|END_ENTITY There was , over-all , a significant correlation between Kins and Kitt , indicating that insulin sensitivity of 1-14C-glucose oxidation by adipose tissue in vitro reflects the general state of sensitivity of glucose metabolism to insulin in vivo in obese human subjects . 6352541 3 1-14C-glycine 787,800 insulin 732,739 1-14C-glycine insulin null 396145(Tax:9031) Chemical Gene labelling|advcl|START_ENTITY increase|acl|labelling produced|dobj|increase produced|nsubj|Tri-iodo-thyronine Tri-iodo-thyronine|conj|END_ENTITY Tri-iodo-thyronine and insulin produced a 200 % increase in 14C labelling from 1-14C-glycine . 7136756 2 1-14C-labelled_amino_acids 483,509 ornithine_decarboxylase 400,423 1-14C-labelled amino acids ornithine decarboxylase null 18263(Tax:10090) Chemical Gene assayed|nmod|START_ENTITY activities|dep|assayed activities|nmod|lysine lysine|conj|END_ENTITY Administration of nandrolone resulted in an increased kidney weight and elevated activities of lysine and ornithine_decarboxylase -LRB- assayed by measurement of the formation of 14CO2 from the 1-14C-labelled_amino_acids -RRB- . 3942774 1 1-14C-labelled_hepoxilin_A3 84,111 epoxide_hydratase 268,285 1-14C-labelled hepoxilin A3 epoxide hydratase null 65030(Tax:10116) Chemical Gene generated|dep|START_ENTITY generated|dep|lacking lacking|dobj|activity activity|amod|END_ENTITY 1-14C-labelled_hepoxilin_A3 -LRB- 8-hydroxy-11 ,12 - epoxyeicosa-5 ,9,14 - trienoic_acid -RRB- was generated from 1-14C-labelled arachidonic_acid during incubation with a rat lung preparation lacking epoxide_hydratase activity . 410288 1 1-14C-lactose 87,100 lactase 171,178 1-14C-lactose lactase null 3938 Chemical Gene test|amod|START_ENTITY value|nmod|test compared|nsubjpass|value compared|nmod|test test|conj|assay assay|compound|END_ENTITY The diagnostic value of 1-14C-lactose breath test was compared with the standard lactose tolerance test and lactase assay in jejunal biopsies in 16 control subjects , 14 patients with lactase_deficiency -LRB- LD -RRB- proven by lactase assay and 20 patients with irritable_bowel_syndrome -LRB- IBS -RRB- . 410288 1 1-14C-lactose 87,100 lactase 280,287 1-14C-lactose lactase null 3938 Chemical Gene test|amod|START_ENTITY value|nmod|test compared|nsubjpass|value compared|nmod|subjects subjects|appos|patients patients|nmod|lactase_deficiency lactase_deficiency|acl|proven proven|nmod|assay assay|amod|END_ENTITY The diagnostic value of 1-14C-lactose breath test was compared with the standard lactose tolerance test and lactase assay in jejunal biopsies in 16 control subjects , 14 patients with lactase_deficiency -LRB- LD -RRB- proven by lactase assay and 20 patients with irritable_bowel_syndrome -LRB- IBS -RRB- . 410288 4 1-14C-lactose 708,721 lactase 891,898 1-14C-lactose lactase null 3938 Chemical Gene test|amod|START_ENTITY superior|nsubj|test superior|conj|correlation correlation|nmod|absorption absorption|conj|assay assay|compound|END_ENTITY 1-14C-lactose breath test was superior to standard lactose tolerance test in specificity -LRB- P less than 0.05 -RRB- and provided a satisfactory correlation between 14C-lactose absorption and lactase assay -LRB- r = 0.77 -RRB- . 10232692 1 1-14C_leucine 514,527 insulin 411,418 1-14C leucine insulin null 3630 Chemical Gene infusion|amod|START_ENTITY calorimetry|conj|infusion combination|nmod|calorimetry performed|nmod|combination performed|nsubjpass|studies studies|compound|END_ENTITY Euglycemic insulin clamp studies -LRB- 180 min -RRB- were performed in combination with continuous indirect calorimetry and 1-14C_leucine infusion -LRB- study I -RRB- . 1568347 2 1-14C-leucine 366,379 GH 407,409 1-14C-leucine GH null 2688 Chemical Gene infusion|amod|START_ENTITY using|dobj|infusion using|nmod|administration administration|compound|END_ENTITY DESIGN : Whole body leucine kinetics were measured in post-absorptive conditions using a 1-14C-leucine infusion before and during GH administration -LRB- 0.0125 mg/kg/day ; 0.033 U/kg/day -RRB- for 7 days . 11858764 4 1-14C-linoleic_acid 803,822 delta-6_desaturase 696,714 1-14C-linoleic acid delta-6 desaturase null 83512(Tax:10116) Chemical Gene using|dobj|START_ENTITY fraction|acl|using determined|nmod|fraction determined|nsubjpass|activity activity|amod|END_ENTITY The hepatic delta-6_desaturase activity in hHTg rats was determined radiometrically in a microsomal fraction using the 1-14C-linoleic_acid as substrate . 3201996 2 1-14C_linolenate_n6 605,624 delta_6_desaturase 516,534 1-14C linolenate n6 delta 6 desaturase null 83512(Tax:10116) Chemical Gene measured|nmod|START_ENTITY activity|acl|measured activity|amod|END_ENTITY In liver and kidney this correlated with a significant decrease in the first dietary condition , and with an increase in the second , of delta_6_desaturase activity , measured by the rate of conversion of 1-14C linoleate n6 to 1-14C_linolenate_n6 . 1858038 4 1-14C-palmitate 896,911 IL-1_alpha 770,780 1-14C-palmitate IL-1 alpha null 24493(Tax:10116) Chemical Gene oxidation|nmod|START_ENTITY mRNA|conj|oxidation increased|dobj|mRNA increased|nsubj|END_ENTITY We showed that IL-1_alpha significantly increased CPT mRNA , 35S-methionine incorporation CPT protein , and hepatic mitochondrial oxidation of 1-14C-palmitate to acid soluble products . 14732449 4 1-14C-palmitate 496,511 leptin 662,668 1-14C-palmitate leptin null 396832(Tax:9823) Chemical Gene U-14C-glucose|conj|START_ENTITY metabolism|amod|U-14C-glucose assessed|dobj|metabolism assessed|parataxis|control control|conj|END_ENTITY Experiments assessed U-14C-glucose or 1-14C-palmitate metabolism in isolated adipocytes exposed to : basal medium -LRB- control -RRB- , 100 nM insulin , 100 ng/ml porcine growth hormone , 100 ng/ml recombinant porcine leptin , and combinations of these hormones . 1701451 3 1-14C-propionate 676,692 methylmalonyl-CoA_mutase 619,643 1-14C-propionate methylmalonyl-CoA mutase null 688517(Tax:10116) Chemical Gene production|nmod|START_ENTITY activity|appos|production activity|amod|END_ENTITY Consistent with decreased methylmalonyl-CoA_mutase activity , 14CO2 production from 1-14C-propionate -LRB- 1 mM -RRB- was decreased by 76 % and 82 % after 2-3 wk and 5-6 wk of HCCL treatment , respectively . 3405240 1 1-14C_pyruvate 154,168 CO2 134,137 1-14C pyruvate CO2 null 717 Chemical Gene stimulated|nmod|START_ENTITY stimulated|dobj|production production|compound|END_ENTITY L-carnitine stimulated CO2 production from 1-14C_pyruvate in mitochondria from human skeletal muscle nearly twofold . 23943853 7 11525A 903,909 hAGT 852,856 11525A hAGT null 183 Chemical Gene allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|nmod|3 3|amod|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 23943853 7 11525A 903,909 miR-31 812,818 11525A miR-31 null 407035 Chemical Gene allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 23943853 7 11525A 903,909 miR-584 823,830 11525A miR-584 null 693169 Chemical Gene allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|miR-31 miR-31|conj|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 23943853 7 11525C 875,881 hAGT 852,856 11525C hAGT null 183 Chemical Gene allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|nmod|3 3|amod|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 23943853 7 11525C 875,881 miR-31 812,818 11525C miR-31 null 407035 Chemical Gene allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 23943853 7 11525C 875,881 miR-584 823,830 11525C miR-584 null 693169 Chemical Gene allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|miR-31 miR-31|conj|END_ENTITY We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele . 25049736 4 1153C 523,528 TYRP1 569,574 1153C TYRP1 null 7306 Chemical Gene _|compound|START_ENTITY _|conj|_ SNPs|dep|_ found|nsubjpass|SNPs found|nmod|region region|nmod|gene gene|compound|END_ENTITY Two SNPs -LRB- 367T _ > _ C and 1153C _ > _ T -RRB- were found in the coding region of TYRP1 gene , but had no significant association with plumage phenotype in Korean quails . 16299517 3 1,157-nucleotide 333,349 TLC1 380,384 1,157-nucleotide TLC1 null 9164870 Chemical Gene RNA|amod|START_ENTITY RNA|compound|END_ENTITY Here , we reduce the 1,157-nucleotide -LRB- nt -RRB- Saccharomyces_cerevisiae TLC1 RNA to a size smaller than the 451-nt human RNA while retaining function in vivo . 8483502 2 115_amino-acid 324,338 IL-5 281,285 115 amino-acid IL-5 null 3567 Chemical Gene residues|amod|START_ENTITY homodimer|nmod|residues homodimer|nsubj|END_ENTITY Human IL-5 is a disulphide-linked homodimer with 115_amino-acid residues in each chain . 731729 1 115mCd 200,206 Cd2 184,187 115mCd Cd2 null 497761(Tax:10116) Chemical Gene containing|dobj|START_ENTITY +|acl|containing +|compound|END_ENTITY -LSB- 3_H -RSB- _ Cystine and 115mCd were incorporated into hepatic and renal Cd-thionein in response to sc administration of 4.4 mumol of Cd2 + containing 115mCd . 731729 1 115mCd 75,81 Cd2 184,187 115mCd Cd2 null 497761(Tax:10116) Chemical Gene Cystine|conj|START_ENTITY sc|nsubj|Cystine sc|dobj|administration administration|nmod|mumol mumol|nmod|+ +|compound|END_ENTITY -LSB- 3_H -RSB- _ Cystine and 115mCd were incorporated into hepatic and renal Cd-thionein in response to sc administration of 4.4 mumol of Cd2 + containing 115mCd . 731729 2 115mCd 226,232 Cd2 276,279 115mCd Cd2 null 497761(Tax:10116) Chemical Gene reached|nsubj|START_ENTITY reached|nmod|injection injection|amod|END_ENTITY Cd-thionein-bound 115mCd reached a plateau by 24 and 72 h after the Cd2 + injection in liver and kidney , respectively . 9218510 7 116-123 915,922 MBP 870,873 116-123 MBP MESH:C477353 4155 Chemical Gene MBP|appos|START_ENTITY corresponded|nmod|MBP corresponded|nsubj|epitope epitope|nmod|recognition recognition|compound|END_ENTITY The major T cell epitope for MBP recognition corresponded to residues MBP -LRB- 116-123 -RRB- . 9218510 7 116-123 915,922 MBP 911,914 116-123 MBP MESH:C477353 4155 Chemical Gene END_ENTITY|appos|START_ENTITY The major T cell epitope for MBP recognition corresponded to residues MBP -LRB- 116-123 -RRB- . 21593163 1 1,162-amino-acid 206,222 LANA 195,199 1,162-amino-acid LANA null 4961527(Tax:37296) Chemical Gene protein|amod|START_ENTITY protein|nsubj|latency-associated_nuclear_antigen latency-associated_nuclear_antigen|appos|END_ENTITY Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated_nuclear_antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that acts on viral terminal repeat -LRB- TR -RRB- DNA to mediate KSHV episome persistence . 24006437 1 1,162-amino-acid 230,246 LANA 219,223 1,162-amino-acid LANA null 4961527(Tax:37296) Chemical Gene protein|amod|START_ENTITY protein|nsubj|antigen antigen|appos|END_ENTITY Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated nuclear antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that mediates the maintenance of episomal viral genomes in latently infected cells . 21593163 1 1,162-amino-acid 206,222 latency-associated_nuclear_antigen 159,193 1,162-amino-acid latency-associated nuclear antigen null 4961527(Tax:37296) Chemical Gene protein|amod|START_ENTITY protein|nsubj|END_ENTITY Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated_nuclear_antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that acts on viral terminal repeat -LRB- TR -RRB- DNA to mediate KSHV episome persistence . 14558925 2 116-amino_acid_polypeptide_prohormone 254,291 CALC-1 221,227 116-amino acid polypeptide prohormone CALC-1 MESH:C477353 796 Chemical Gene products|nmod|START_ENTITY products|compound|END_ENTITY Other CALC-1 gene products such as the 116-amino_acid_polypeptide_prohormone , procalcitonin , as well as its component calcitonin precursors -LRB- CTpr -RRB- may also be increased in their sera . 14558925 2 116-amino_acid_polypeptide_prohormone 254,291 calcitonin 333,343 116-amino acid polypeptide prohormone calcitonin MESH:C477353 796 Chemical Gene START_ENTITY|appos|procalcitonin procalcitonin|conj|precursors precursors|compound|END_ENTITY Other CALC-1 gene products such as the 116-amino_acid_polypeptide_prohormone , procalcitonin , as well as its component calcitonin precursors -LRB- CTpr -RRB- may also be increased in their sera . 18075234 2 116-amino_acid_propeptide 174,199 calcitonin 203,213 116-amino acid propeptide calcitonin MESH:C054836 796 Chemical Gene START_ENTITY|nmod|END_ENTITY Procalcitonin -LRB- PCT -RRB- , a 116-amino_acid_propeptide of calcitonin , is a new marker of bacterial_infections and sepsis . 18086127 5 116-glutamine 1021,1034 Bdnf 823,827 116-glutamine Bdnf MESH:C477353 12064(Tax:10090) Chemical Gene tract|amod|START_ENTITY express|nmod|tract mice|acl:relcl|express forebrain|nmod|mice BDNF|nmod|forebrain II|nmod|BDNF kinase|dep|II kinase|dep|employed employed|dep|driven driven|nsubj|transgene transgene|compound|END_ENTITY We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract . 18086127 5 116-glutamine 1021,1034 BDNF 940,944 116-glutamine BDNF MESH:C477353 12064(Tax:10090) Chemical Gene tract|amod|START_ENTITY express|nmod|tract mice|acl:relcl|express forebrain|nmod|mice END_ENTITY|nmod|forebrain We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract . 18086127 5 116-glutamine 1021,1034 htt 1010,1013 116-glutamine htt MESH:C477353 15194(Tax:10090) Chemical Gene tract|amod|START_ENTITY express|nmod|tract express|dobj|fragment fragment|nmod|END_ENTITY We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract . 7958949 2 1173-amino-acid 244,259 cKr2 206,210 1173-amino-acid cKr2 null 396155(Tax:9031) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein cDNA|acl:relcl|encodes cDNA|nsubj|END_ENTITY cKr2 is a 4492-bp cDNA that encodes a 1173-amino-acid -LRB- aa -RRB- protein with two domains : the N-terminal portion contains 16 zinc fingers -LRB- Zf -RRB- of the 2Cys + 2His class , while the C-terminal domain contains a stretch of 181 aa which consists of seven consecutive sequence repeats each being 24 aa in length . 15358623 7 1173CC 1088,1094 VKORC1 1081,1087 1173CC VKORC1 MESH:D002996 79001 Chemical Gene genotype|nummod|START_ENTITY genotype|compound|END_ENTITY Regardless of the presence of confounding variables , the mean adjusted dose required of warfarin was higher -LRB- 6.2 mg -RRB- among patients with the VKORC1 1173CC genotype than those of patients carrying the CT -LRB- 4.8 mg ; P = .002 -RRB- or the TT genotype -LRB- 3.5 mg ; P < .001 -RRB- . 18240904 8 1173_TC 1604,1611 VKORC1 1597,1603 1173 TC VKORC1 MESH:C078891 79001 Chemical Gene START_ENTITY|nummod|END_ENTITY For the Japanese cardiovascular surgery patients , the maintenance dose of warfarin was significantly larger in the combined VKORC1 1173_TC and CC genotype group than in the 1173 TT genotype group -LRB- 3.6 + / - 0.5 mg vs 2.8 + / - 0.7 mg , respectively ; p = 0.02 -RRB- . 25301491 5 1174C 1201,1206 WFS1 1096,1100 1174C WFS1 null 7466 Chemical Gene _|nummod|START_ENTITY substitution|dep|_ frameshift|conj|substitution leading|nmod|frameshift found|parataxis|leading found|xcomp|heterozygote heterozygote|nmod|mutations mutations|nmod|exon exon|nmod|gene gene|compound|END_ENTITY The patient was found to be a compound heterozygote for two novel mutations in exon 8 of WFS1 gene : a 2-bp deletion AT at nt 1539 leading to a frameshift -LRB- Y513fs -RRB- and a single-base substitution 1174C _ > _ T resulting in a stop codon -LRB- Q392X -RRB- . 27159682 2 11778G 445,451 MT-ND4 460,466 11778G MT-ND4 null 4538 Chemical Gene ___|compound|START_ENTITY >|nummod|___ carrying|dobj|> families|acl|carrying DNA|nmod|families analysis|nmod|DNA report|dobj|analysis report|xcomp|___ ___|dobj|mutation mutation|appos|END_ENTITY We report here the clinical , genetic and molecular analysis of mitochondrial DNA -LRB- mtDNA -RRB- in eight Han Chinese families carrying the known mitochondrial 11778G ___ > ___ A -LRB- MT-ND4 -RRB- mutation . 9784061 2 1177-amino-acid 305,320 DBP 229,232 1177-amino-acid DBP null 1628 Chemical Gene polypeptide|amod|START_ENTITY coding|dobj|polypeptide capable|advcl|coding nucleotides|amod|capable frame|nmod|nucleotides has|dobj|frame has|nsubj|gene gene|compound|END_ENTITY The DBP gene has an open reading frame of 3531 nucleotides , capable of coding a 1177-amino-acid polypeptide of 125 kDa . 22433867 8 117-amino_acid 1294,1308 huntingtin 1270,1280 117-amino acid huntingtin MESH:C071047 3064 Chemical Gene fragment|amod|START_ENTITY shortstop|appos|fragment shortstop|compound|END_ENTITY Interestingly , comparable oligomeric species were not observed for expanded huntingtin shortstop , a 117-amino_acid fragment of huntingtin shown previously in mammalian cell lines and transgenic_mice , and here in primary cortical neurons , to be non-toxic . 22433867 8 117-amino_acid 1294,1308 huntingtin 1321,1331 117-amino acid huntingtin MESH:C071047 3064 Chemical Gene fragment|amod|START_ENTITY fragment|nmod|END_ENTITY Interestingly , comparable oligomeric species were not observed for expanded huntingtin shortstop , a 117-amino_acid fragment of huntingtin shown previously in mammalian cell lines and transgenic_mice , and here in primary cortical neurons , to be non-toxic . 26489467 4 117-amino-acid 483,497 CRM1 555,559 117-amino-acid CRM1 null 7514 Chemical Gene fragment|amod|START_ENTITY fragment|nmod|complex complex|nmod|END_ENTITY Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution . 26489467 4 117-amino-acid 483,497 Nup214 531,537 117-amino-acid Nup214 null 8021 Chemical Gene fragment|amod|START_ENTITY fragment|nmod|END_ENTITY Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution . 7490091 5 117-amino-acid 741,755 ribosomal_protein_L34 786,807 117-amino-acid ribosomal protein L34 null 362041(Tax:10116) Chemical Gene protein|amod|START_ENTITY encoding|dobj|protein encoding|nmod|END_ENTITY A full-length cDNA clone encoding a 117-amino-acid protein homologous to the rat ribosomal_protein_L34 was isolated . 26489467 4 117-amino-acid 483,497 Snurportin_1 561,573 117-amino-acid Snurportin 1 null 10073 Chemical Gene fragment|amod|START_ENTITY fragment|nmod|complex complex|nmod|CRM1 CRM1|conj|END_ENTITY Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution . 21411255 4 1181G 861,866 TNFRSF11B 807,816 1181G TNFRSF11B null 4982 Chemical Gene C|nummod|START_ENTITY G|conj|C G|compound|END_ENTITY STUDY DESIGN : 478 postmenopausal women were genotyped for the presence of TNFRSF11B gene polymorphisms 245T _ > _ G -LRB- rs3134069 -RRB- and 1181G _ > _ C -LRB- rs2073618 -RRB- . 10381377 3 1183-amino-acid 395,410 SHIP2 374,379 1183-amino-acid SHIP2 MESH:C403900 65038(Tax:10116) Chemical Gene protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY Rat SHIP2 cDNA encodes a 1183-amino-acid protein that is 45 % identical with rat SHIP . 14617087 5 1188-amino-acid 497,512 BRI1 562,566 1188-amino-acid BRI1 null 830095(Tax:3702) Chemical Gene protein|amod|START_ENTITY protein|acl:relcl|has has|nmod|END_ENTITY PsBRI1 is predicted to encode a 1188-amino-acid protein that has 78 % similarity with Arabidopsis BRI1 . 1415682 2 1-188_amino_acids 735,752 lipocortin-1 763,775 1-188 amino acids lipocortin-1 null 301 Chemical Gene fragment|dep|START_ENTITY fragment|nmod|END_ENTITY Administration -LRB- icv -RRB- of a recombinant fragment -LRB- NH2-terminus , 1-188_amino_acids -RRB- of human lipocortin-1 -LRB- 1.2 micrograms -RRB- produced small increases in VO2 -LRB- < 5 % -RRB- and body temperature -LRB- < 0.3 degrees C -RRB- . 19706609 5 11894-11899 914,925 SULT1A1 839,846 11894-11899 SULT1A1 MESH:C090474 6817 Chemical Gene Biochemistry|nummod|START_ENTITY G.|dep|Biochemistry Tyapochkin|conj|G. END_ENTITY|dep|Tyapochkin Previously , isotope exchange at equilibrium indicated steady-state ordered mechanism with PAPS and PAP binding to the free SULT1A1 -LRB- Tyapochkin , E. , Cook , P. F. , and Chen , G. -LRB- 2008 -RRB- Biochemistry 47 , 11894-11899 -RRB- . 10673031 5 118-amino-acid 564,578 RAD52beta 611,620 118-amino-acid RAD52beta null 201299 Chemical Gene residues|amod|START_ENTITY -|conj|residues consist|nmod|- consist|conj|designated designated|nmod|END_ENTITY The three isoforms consist of 226 - , 139 - , and 118-amino-acid residues , and are designated as RAD52beta , gamma , and delta , respectively . 12737519 5 118-amino-acid 1160,1174 RAP30 1084,1089 118-amino-acid RAP30 null 2963 Chemical Gene residuals|amod|START_ENTITY RMP|nmod|residuals domain|nmod|RMP interact|nmod|domain interact|nsubj|END_ENTITY Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain . 12737519 5 118-amino-acid 1160,1174 RAP74 1094,1099 118-amino-acid RAP74 null 2962 Chemical Gene residuals|amod|START_ENTITY RMP|nmod|residuals domain|nmod|RMP interact|nmod|domain interact|nsubj|RAP30 RAP30|conj|END_ENTITY Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain . 12737519 5 118-amino-acid 1160,1174 RMP 1153,1156 118-amino-acid RMP null 8725 Chemical Gene residuals|amod|START_ENTITY END_ENTITY|nmod|residuals Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain . 19332070 5 118-amino_acids 905,920 CART 885,889 118-amino acids CART null 100286783(Tax:8030) Chemical Gene gene|amod|START_ENTITY gene|amod|END_ENTITY The CART gene , encoding 118-amino_acids , was strongly expressed in the brain and eye . 15936720 9 11-9-1-4 1060,1068 c-fos 1015,1020 11-9-1-4 c-fos MESH:C087567 2353 Chemical Gene expression|nmod|START_ENTITY expression|amod|END_ENTITY Ro5-4864 also upregulates c-fos expression in breast_cancer cell lines 11-9-1-4 and BT-549 , while expression in non-tumorigenic cell line MCF-12A was either basal or slightly downregulated . 15936720 10 11-9-1-4 1248,1256 CPT 1221,1224 11-9-1-4 CPT MESH:C087567 56994 Chemical Gene breast_cancer|appos|START_ENTITY examined|nmod|breast_cancer examined|dobj|expression expression|nmod|gene gene|compound|END_ENTITY We further examined the expression of the CPT gene in breast_cancer -LRB- 11-9-1-4 , BT-549 -RRB- and non-tumorigenic cell lines -LRB- MCF-12A , MCF-12F -RRB- . 1283051 3 1194P 1324,1329 IRBP 1273,1277 1194P IRBP null 19661(Tax:10090) Chemical Gene proline|nummod|START_ENTITY END_ENTITY|conj|proline On the other hand , two amino_acids of IRBP , amino_acid positions 1182W -LRB- tryptophane -RRB- and 1194P -LRB- proline -RRB- were shown to be the agretopes inducing autoimmune_uveoretinitis in the TG nude mouse . 19123050 4 1199A 585,590 MDR1 564,568 1199A MDR1 null 5243 Chemical Gene MDR1|appos|START_ENTITY END_ENTITY|conj|MDR1 RESULTS : The recombinant cells MDR1 -LRB- wt -RRB- and MDR1 -LRB- 1199A -RRB- displayed comparable doxorubicin resistance . 19123050 4 1199A 585,590 MDR1 578,582 1199A MDR1 null 5243 Chemical Gene END_ENTITY|appos|START_ENTITY RESULTS : The recombinant cells MDR1 -LRB- wt -RRB- and MDR1 -LRB- 1199A -RRB- displayed comparable doxorubicin resistance . 23716179 11 119G 1501,1505 TP53 1510,1514 119G TP53 null 7157 Chemical Gene polymorphism|nummod|START_ENTITY polymorphism|compound|END_ENTITY We conclude that the Ex4 _ + _ 119G _ > _ C TP53 polymorphism is an independent , low penetrance marker of BC risk in this population . 23716179 12 119G 1664,1668 TP53 1673,1677 119G TP53 null 7157 Chemical Gene C|nummod|START_ENTITY C|nummod|END_ENTITY In addition , our findings suggest that the combination of Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 genotypes confers a higher risk to develop BC . 23716179 13 119G 1787,1791 TP53 1796,1800 119G TP53 null 7157 Chemical Gene genotype|nummod|START_ENTITY genotype|compound|END_ENTITY Also , a possible association of the Ex4 _ + _ 119G _ > _ C TP53 genotype with decreased disease-free survival in these patients is proposed . 23716179 8 119G 1051,1055 TP53 1060,1064 119G TP53 null 7157 Chemical Gene polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY Carriers of at least one Pro allele of the Ex4 _ + _ 119G _ > _ C TP53 polymorphism presented a significant BC risk -LSB- OR = 1.34 , -LRB- 95 % CI 1.03-1 .75 -RRB- , p value = 0.029 -RSB- . 23716179 9 119G 1265,1269 TP53 1274,1278 119G TP53 null 7157 Chemical Gene END_ENTITY|compound|START_ENTITY The epistatic gene-gene analysis showed that the best two-locus model was the combination between Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 showing OR of 1.44 -LRB- 95 % CI 1.10-1 .88 , p value = 0.0083 -RRB- . 23716179 12 119G 1664,1668 VEGFR1 1691,1697 119G VEGFR1 null 2321 Chemical Gene C|nummod|START_ENTITY C|conj|genotypes genotypes|compound|END_ENTITY In addition , our findings suggest that the combination of Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 genotypes confers a higher risk to develop BC . 23716179 9 119G 1265,1269 VEGFR1 1292,1298 119G VEGFR1 null 2321 Chemical Gene TP53|compound|START_ENTITY TP53|conj|END_ENTITY The epistatic gene-gene analysis showed that the best two-locus model was the combination between Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 showing OR of 1.44 -LRB- 95 % CI 1.10-1 .88 , p value = 0.0083 -RRB- . 20370508 11 11A 1765,1768 19A 1760,1763 11A 19A null 57823 Chemical Gene END_ENTITY|appos|START_ENTITY Of particular concern was the high prevalence of MDR pneumococci in non-PCV7 serotypes with an MDR serotype 19A , 11A , 3 , and 6A being mostly responsible . 20370508 2 11A 438,441 19A 428,431 11A 19A null 57823 Chemical Gene 19F|amod|START_ENTITY 19F|amod|END_ENTITY The predominant serotypes were 19F , 19A , 23F , 11A , 3 , 6A , and 6B , accounting for 67.8 % of all isolates . 20370508 8 11A 1384,1387 19A 1370,1373 11A 19A null 57823 Chemical Gene END_ENTITY|conj|START_ENTITY MDR strains were relatively associated with serotypes 19F , 19A , 23F , and 11A , accounting for 58.0 % of the isolates . 22440017 12 11A 1686,1689 19A 1611,1614 11A 19A null 57823 Chemical Gene 6B|appos|START_ENTITY isolated|nsubjpass|6B found|parataxis|isolated found|nsubjpass|Serotypes Serotypes|nummod|END_ENTITY Serotypes 15B , 19A and 21 were mainly found as single carriage ; in contrast serotypes 6B , 11A and 20 , as well as infrequent serotypes , were isolated mainly as part of multiple carriage . 26226445 11 11A 1249,1252 19A 1237,1240 11A 19A null 57823 Chemical Gene 35B|conj|START_ENTITY 35B|conj|END_ENTITY Commonly carried serotypes included 35B -LRB- 15.2 % -RRB- , 15B/C -LRB- 14.2 % -RRB- , 19A -LRB- 9.6 % -RRB- , 11A -LRB- 8 % -RRB- , 23B -LRB- 5.6 % -RRB- , 6C -LRB- 5.3 % -RRB- , 21 -LRB- 5 % -RRB- , and 15A -LRB- 5 % -RRB- ; 13.9 % were PCV13 serotypes . 28776337 4 11A 805,808 19A 764,767 11A 19A null 57823 Chemical Gene END_ENTITY|conj|START_ENTITY The most common serotypes were 19A -LRB- 14.0 % -RRB- , 23A -LRB- 12.8 % -RRB- , 15B/C -LRB- 10.7 % -RRB- , 11A -LRB- 10.1 % -RRB- , 6C -LRB- 7.8 % -RRB- , and 6A -LRB- 6.3 % -RRB- among the typeable pneumococci -LRB- n = 335 -RRB- . 3106148 5 11A 917,920 cac 929,932 11A cac null 32158(Tax:7227) Chemical Gene Duplications|nmod|START_ENTITY covered|nsubj|Duplications covered|dobj|END_ENTITY Duplications including distal 11A covered cac . 28340620 7 11A4H 1492,1497 FVIII 1357,1362 11A4H FVIII null 2157 Chemical Gene line|dep|START_ENTITY IU/ml|dep|line secreted|dobj|IU/ml cells|acl|secreted END_ENTITY|dep|cells Immediately after the primary selection FVIII - producing cells secreted 5-10 IU/ml of FVIII-BDD , and after multi-stage methotrexate-driven amplification a stable clonal line 11A4H was selected , secreting 39 IU/ml of FVIII-BDD in the simple batch culturing conditions , which considerably exceeds known indicators for industrial producers of this protein . 28340620 8 11A4H 1720,1725 FVIII 1769,1774 11A4H FVIII null 2157 Chemical Gene accumulates|nsubj|START_ENTITY accumulates|dobj|proportion proportion|nmod|END_ENTITY In contrast to other FVIII-BDD producing lines 11A4H accumulates low proportion of the secreted FVIII on the membrane . 8630880 1 11A8-SAP 332,340 basic_fibroblast_growth_factor 237,267 11A8-SAP basic fibroblast growth factor null 2247 Chemical Gene forms|conj|START_ENTITY forms|nmod|saporin saporin|compound|END_ENTITY BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice . 8630880 1 11A8-SAP 332,340 bFGF 269,273 11A8-SAP bFGF null 2247 Chemical Gene forms|conj|START_ENTITY forms|nmod|saporin saporin|appos|END_ENTITY BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice . 8630880 1 11A8-SAP 332,340 bFGF 297,301 11A8-SAP bFGF null 2247 Chemical Gene START_ENTITY|amod|END_ENTITY BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice . 10073575 7 11A_and_B 1064,1073 HNF-3alpha 1019,1029 11A and B HNF-3alpha null 3169 Chemical Gene Cotransfection|conj|START_ENTITY Cotransfection|nmod|vectors vectors|nmod|END_ENTITY Cotransfection with expression vectors of HNF-3alpha and beta , but not the related HFH 11A_and_B , specifically activated the wild-type TFF1 reporter genes . 10073575 7 11A_and_B 1064,1073 TFF1 1112,1116 11A and B TFF1 null 7031 Chemical Gene Cotransfection|conj|START_ENTITY activated|nsubj|Cotransfection activated|dobj|genes genes|compound|END_ENTITY Cotransfection with expression vectors of HNF-3alpha and beta , but not the related HFH 11A_and_B , specifically activated the wild-type TFF1 reporter genes . 17084873 3 11_acid_amides 696,710 PPARalpha 529,538 11 acid amides PPARalpha null 19013(Tax:10090) Chemical Gene organochlorines|conj|START_ENTITY pesticides|dep|organochlorines activities|nmod|pesticides END_ENTITY|conj|activities In the present study , we characterized mouse PPARalpha and PPARgamma agonistic activities of 200 pesticides -LRB- 29 organochlorines , _ 11_diphenyl_ethers , 56 organophosphorus pesticides , 12 pyrethroids , 22 carbamates , 11_acid_amides , 7 triazines , 8 ureas and 44 others -RRB- by in vitro reporter gene assays using CV-1 monkey kidney cells . 17084873 3 11_acid_amides 696,710 PPARgamma 543,552 11 acid amides PPARgamma null 19016(Tax:10090) Chemical Gene organochlorines|conj|START_ENTITY pesticides|dep|organochlorines activities|nmod|pesticides activities|compound|END_ENTITY In the present study , we characterized mouse PPARalpha and PPARgamma agonistic activities of 200 pesticides -LRB- 29 organochlorines , _ 11_diphenyl_ethers , 56 organophosphorus pesticides , 12 pyrethroids , 22 carbamates , 11_acid_amides , 7 triazines , 8 ureas and 44 others -RRB- by in vitro reporter gene assays using CV-1 monkey kidney cells . 19053888 6 11a-d 1199,1204 ABCB1 1242,1247 11a-d ABCB1 null 5243 Chemical Gene N-4-methylpiperazine|dep|START_ENTITY derivatives|amod|N-4-methylpiperazine END_ENTITY|nsubj|derivatives N-4-methylpiperazine - -LRB- 10a-d -RRB- and tetrahydroisoquinoline - -LRB- 11a-d -RRB- derivatives were Cyclosporin A-like ABCB1 nontransported substrates . 15317800 5 1,1a-dihydroxy-1-hydro-9-fluorenone 452,487 FlnB 389,393 1,1a-dihydroxy-1-hydro-9-fluorenone FlnB null 2317 Chemical Gene 9-fluorenol|conj|START_ENTITY exhibited|nmod|9-fluorenol exhibited|nsubj|protein protein|compound|END_ENTITY The FlnB protein exhibited activities against both 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone to produce 9-fluorenone and 2 ' - carboxy-2 ,3 - dihydroxybiphenyl , respectively . 22209708 4 11a-hydroxyl 710,722 C-11 685,689 11a-hydroxyl C-11 null 51728 Chemical Gene group|amod|START_ENTITY removed|nsubj|group reduced|conj|removed reduced|nsubjpass|moiety moiety|nmod|END_ENTITY Next , the carbonyl moiety at C-11 was reduced and the 11a-hydroxyl group removed through utilization of the Barton-McCombie_reaction . 22588088 1 11a-hydroxyl_canrenone 223,245 C-7 207,210 11a-hydroxyl canrenone C-7 null 730 Chemical Gene 4|amod|START_ENTITY position|nmod|4 position|compound|END_ENTITY A novel and efficient method of stereoselectively introducing a-nitromethyl group to C-7 position of 11a-hydroxyl_canrenone 4 was described . 16320207 4 11alpha,13-dihydrohelenalin 749,776 IL-8 819,823 11alpha,13-dihydrohelenalin IL-8 MESH:C026745 20309(Tax:10090) Chemical Gene derivatives|amod|START_ENTITY that|nmod|derivatives comparable|nmod|that activity|amod|comparable possessing|dobj|activity compounds|acl|possessing gave|dobj|compounds gave|nmod|EMSA EMSA|conj|ELISA ELISA|compound|END_ENTITY Formation of these adducts gave compounds possessing an inhibitory activity comparable to that of 11alpha,13-dihydrohelenalin derivatives in the NF-kappaB EMSA and the IL-8 ELISA in vitro assays as well as in the in vivo croton oil-induced mouse ear edema test for one adduct , namely 2beta-ethoxy-6-O-acetyl-2 ,3 - dihydrohelenalin . 9348104 5 11alpha,13-dihydrohelenalin 713,740 NF-kappaB 803,812 11alpha,13-dihydrohelenalin NF-kappaB MESH:C026745 4790 Chemical Gene degree|amod|START_ENTITY inhibit|nmod|degree inhibit|dobj|activation activation|nmod|END_ENTITY We show here that helenalin , and , to a much lesser degree , 11alpha,13-dihydrohelenalin and chamissonolid , inhibit activation of transcription factor NF-kappaB . 17223084 3 11alpha-hydroxyprogesterone 755,782 UGT2B15 630,637 11alpha-hydroxyprogesterone UGT2B15 MESH:C030228 7366 Chemical Gene zidovudine|conj|START_ENTITY substrates|amod|zidovudine testosterone|conj|substrates substrates|dobj|testosterone glucuronidated|ccomp|substrates glucuronidated|nsubj|61-194 61-194|nmod|END_ENTITY A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone . 17223084 3 11alpha-hydroxyprogesterone 755,782 UGT2B15 657,664 11alpha-hydroxyprogesterone UGT2B15 MESH:C030228 7366 Chemical Gene zidovudine|conj|START_ENTITY substrates|amod|zidovudine testosterone|conj|substrates substrates|dobj|testosterone substrates|nsubj|END_ENTITY A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone . 17223084 3 11alpha-hydroxyprogesterone 755,782 UGT2B7 722,728 11alpha-hydroxyprogesterone UGT2B7 MESH:C030228 7364 Chemical Gene zidovudine|conj|START_ENTITY substrates|amod|zidovudine substrates|nummod|END_ENTITY A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone . 18717339 3 11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B 454,509 C21 286,289 11alpha-O-2-methylbutyryl-12beta-O-acetyl tenacigenin B C21 null 79718 Chemical Gene 17beta-tenacigenin_B|conj|START_ENTITY identified|nmod|17beta-tenacigenin_B extract|acl:relcl|identified isolated|nmod|extract isolated|nsubjpass|steroids steroids|compound|END_ENTITY Eight C21 steroids were isolated from the CHCl3 extract , which were identified as 11alpha-O-tigloyl-17beta-tenacigenin_B -LRB- 1 -RRB- , 17beta-tenacigenin_B -LRB- 2 -RRB- , tenacigenoside_A -LRB- 3 -RRB- , 11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B -LRB- 4 -RRB- , tenacissoside_H -LRB- 5 -RRB- , marsdenoside_A -LRB- 6 -RRB- , tenacissoside_G -LRB- 7 -RRB- , and tenacissoside_I -LRB- 8 -RRB- . 9920094 4 11alpha-OH-progesterone 722,745 progesterone_receptor 599,620 11alpha-OH-progesterone progesterone receptor null 5241 Chemical Gene was|nsubj|START_ENTITY reversed|parataxis|was reversed|nmod|requirements requirements|dep|independent independent|nmod|END_ENTITY Inhibition : 1 -RRB- was reversed by progesterone removal ; 2 -RRB- was independent of the progesterone_receptor -LRB- not blocked by the receptor antagonist RU40555 -RRB- ; and 3 -RRB- exhibited specific structural requirements ; 11alpha-OH-progesterone was inhibitory , whereas its stereoisomer 11beta-OH-progesterone was not . 18717339 3 11alpha-O-tigloyl-17beta-tenacigenin_B 362,400 C21 286,289 11alpha-O-tigloyl-17beta-tenacigenin B C21 null 79718 Chemical Gene 17beta-tenacigenin_B|amod|START_ENTITY identified|nmod|17beta-tenacigenin_B extract|acl:relcl|identified isolated|nmod|extract isolated|nsubjpass|steroids steroids|compound|END_ENTITY Eight C21 steroids were isolated from the CHCl3 extract , which were identified as 11alpha-O-tigloyl-17beta-tenacigenin_B -LRB- 1 -RRB- , 17beta-tenacigenin_B -LRB- 2 -RRB- , tenacigenoside_A -LRB- 3 -RRB- , 11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B -LRB- 4 -RRB- , tenacissoside_H -LRB- 5 -RRB- , marsdenoside_A -LRB- 6 -RRB- , tenacissoside_G -LRB- 7 -RRB- , and tenacissoside_I -LRB- 8 -RRB- . 20953508 1 11-amino-1-undecanethiol 125,149 serum_albumin 270,283 11-amino-1-undecanethiol serum albumin MESH:C510729 213 Chemical Gene monolayer|nmod|START_ENTITY fabricated|nsubjpass|monolayer fabricated|nmod|antibodies antibodies|conj|END_ENTITY A self-assembled monolayer -LRB- SAM -RRB- of 11-amino-1-undecanethiol -LRB- AUT -RRB- has been fabricated onto a gold -LRB- Au -RRB- substrate to co-immobilize anti-ochratoxin-A antibodies -LRB- AO-IgGs -RRB- and bovine serum_albumin -LRB- BSA -RRB- to detect food borne mycotoxin -LSB- i.e. , ochratoxin-A -LRB- OTA -RRB- -RSB- . 18002546 3 11-amino-1-undecanethiol_hydrochloride 399,437 serum_albumin 509,522 11-amino-1-undecanethiol hydrochloride serum albumin null 213 Chemical Gene 1-hexadecanethiol|amod|START_ENTITY types|acl:relcl|1-hexadecanethiol types|conj|END_ENTITY Three types of functional alkylthiols , namely 11-amino-1-undecanethiol_hydrochloride , 1-hexadecanethiol -LRB- 1-hydrochloride , and 1,9-nonanedithiol , and bovine serum_albumin -LRB- BSA -RRB- are investigated in our study . 4448078 1 1-1-amino-3-chloro-2-propanol 57,86 HC1 87,90 1-1-amino-3-chloro-2-propanol HC1 null 387397(Tax:10116) Chemical Gene END_ENTITY|amod|START_ENTITY CL 88,236 -LRB- 1-1-amino-3-chloro-2-propanol HC1 -RRB- was tested orally for antifertility in male rats , mice and hamsters . 15114370 2 11_amino-acid 396,409 CEL 317,320 11 amino-acid CEL null 1056 Chemical Gene residues|amod|START_ENTITY repeats|nmod|residues structure|nmod|repeats consists|nmod|structure consists|nsubj|part part|nmod|END_ENTITY The C-terminal part of CEL consists of a unique structure with proline-rich O-glycosylated repeats of 11_amino-acid residues each . 18284603 1 11-aminoacid 219,231 urotensin_II 200,212 11-aminoacid urotensin II null 10911 Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY BACKGROUND : Human urotensin_II is an 11-aminoacid peptide with a controversial role in the human cardiovascular system . 11403592 3 11-amino_acid 457,470 A_beta 508,514 11-amino acid A beta null 351 Chemical Gene fragment|amod|START_ENTITY fragment|nmod|peptide peptide|appos|END_ENTITY Numerous laboratories have used the smaller 11-amino_acid fragment of the full-length peptide , A_beta -LRB- 25 -- 35 -RRB- , as a convenient alternative in AD investigations since the smaller peptide mimics several of the toxicological and oxidative stress properties of the native full-length peptide . 9624159 4 11-amino_acid 685,698 ACLP 597,601 11-amino acid ACLP MESH:D000596 11568(Tax:10090) Chemical Gene motif|amod|START_ENTITY peptide|conj|motif contains|dobj|peptide protein|acl:relcl|contains protein|nsubj|END_ENTITY ACLP is a nonnuclear protein that contains a signal peptide , a lysine - and proline-rich 11-amino_acid repeating motif , a discoidin-like domain , and a C-terminal domain with 39 % identity to carboxypeptidase_E . 8762146 3 11-amino_acid 504,517 AFP 557,560 11-amino acid AFP null 174 Chemical Gene repeats|amod|START_ENTITY repeats|appos|one one|dep|components components|compound|END_ENTITY It has 52 amino_acids and contains four 11-amino_acid repeats , one more than the major serum AFP components . 9837942 10 11-amino_acid 1403,1416 alpha-actinin 1371,1384 11-amino acid alpha-actinin MESH:D000596 87 Chemical Gene region|amod|START_ENTITY necessary|nsubj|region regulate|parataxis|necessary regulate|dobj|END_ENTITY Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin . 9837942 10 11-amino_acid 1403,1416 alpha-actinin 1475,1488 11-amino acid alpha-actinin MESH:D000596 87 Chemical Gene region|amod|START_ENTITY necessary|nsubj|region necessary|nmod|END_ENTITY Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin . 9837942 10 11-amino_acid 1403,1416 alpha-actinin 1604,1617 11-amino acid alpha-actinin MESH:D000596 87 Chemical Gene region|amod|START_ENTITY necessary|nsubj|region necessary|conj|inhibits inhibits|dobj|association association|nmod|tail tail|nmod|END_ENTITY Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin . 12534279 3 11-amino_acid 443,456 alpha-synuclein 411,426 11-amino acid alpha-synuclein MESH:D000596 6622 Chemical Gene repeats|amod|START_ENTITY comprises|dobj|repeats comprises|nsubj|N-terminus N-terminus|nmod|END_ENTITY The N-terminus of alpha-synuclein comprises seven 11-amino_acid repeats -LRB- XKTKEGVXXXX -RRB- which can form an amphipathic alpha-helix . 3108248 5 11-amino_acid 742,755 apoA-I 676,682 11-amino acid apoA-I null 335 Chemical Gene repeats|amod|START_ENTITY consisting|nmod|repeats repetitive|xcomp|consisting homologous|conj|repetitive homologous|nmod|END_ENTITY The sequence of the protein is homologous to mammalian apoA-I and is highly internally repetitive , consisting largely of 11-amino_acid repeats predicted to have an amphipathic alpha-helical structure . 9054424 1 11-amino_acid 183,196 Apolipoprotein_A-I 127,145 11-amino acid Apolipoprotein A-I null 335 Chemical Gene repeats|amod|START_ENTITY 22-amino_acid|conj|repeats contains|dobj|22-amino_acid contains|nsubj|END_ENTITY Apolipoprotein_A-I contains eight 22-amino_acid and two 11-amino_acid tandem repeats that comprise 80 % of the mature protein . 28592866 6 11-amino_acid 929,942 BB0238 910,916 11-amino acid BB0238 null 2661786(Tax:257310) Chemical Gene region|amod|START_ENTITY able|nsubj|region lacking|ccomp|able lacking|nsubj|END_ENTITY Mutant B. _ burgdorferi isolates producing BB0238 lacking the 11-amino_acid interaction region were able to persist in ticks but failed to transmit to mice or to establish infection . 9837942 10 11-amino_acid 1403,1416 beta2 1351,1356 11-amino acid beta2 MESH:D000596 10242 Chemical Gene region|amod|START_ENTITY necessary|nsubj|region regulate|parataxis|necessary regulate|nsubj|domains domains|nmod|tail tail|amod|END_ENTITY Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin . 16376528 2 11-amino_acid 187,200 beta-galactosidase 392,410 11-amino acid beta-galactosidase null 2720 Chemical Gene fragment|amod|START_ENTITY transduce|nsubj|fragment transduce|parataxis|shown shown|nmod|PTD PTD|nmod|protein protein|amod|END_ENTITY An 11-amino_acid fragment of human immunodeficiency_type_1 -LRB- HIV-1 -RRB- TAT-protein can transduce large , biologically active proteins into mammalian cells ; recent evidence has shown an in vivo PTD for the 116 kDa beta-galactosidase protein . 9624159 4 11-amino_acid 685,698 carboxypeptidase_E 786,804 11-amino acid carboxypeptidase E MESH:D000596 12876(Tax:10090) Chemical Gene motif|amod|START_ENTITY peptide|conj|motif contains|dobj|peptide contains|advcl|END_ENTITY ACLP is a nonnuclear protein that contains a signal peptide , a lysine - and proline-rich 11-amino_acid repeating motif , a discoidin-like domain , and a C-terminal domain with 39 % identity to carboxypeptidase_E . 11350667 4 11-amino_acid 630,643 CD4 721,724 11-amino acid CD4 null 920 Chemical Gene C4|amod|START_ENTITY antibodies|nmod|C4 peptide|nsubj|antibodies peptide|dep|recognize recognize|conj|bound bound|nmod|END_ENTITY Rabbit antibodies to the 11-amino_acid linear C4 peptide did not recognize gp120 in the free state or when bound to CD4 . 10202013 0 11-amino_acid 3,16 CD40 55,59 11-amino acid CD40 MESH:D000596 21939(Tax:10090) Chemical Gene sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest . 10202013 0 11-amino_acid 3,16 c-Jun_N-terminal_kinase 92,115 11-amino acid c-Jun N-terminal kinase MESH:D000596 26419(Tax:10090) Chemical Gene sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|nmod|END_ENTITY An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest . 8626770 5 11-amino_acid 1695,1708 c-met 1723,1728 11-amino acid c-met null 4233 Chemical Gene sequence|amod|START_ENTITY sequence|nmod|initiates initiates|amod|END_ENTITY These findings demonstrate that the 11-amino_acid sequence from c-met initiates epithelial motility via coincident activation of the PI 3-kinase and phospholipase C and that selective activation of the PI 3-kinase can initiate a partial chemotactic response . 8618874 6 11-amino_acid 1240,1253 CPA 1312,1315 11-amino acid CPA null 1357 Chemical Gene sequence|amod|START_ENTITY homology|nmod|sequence attributable|nmod|homology attributable|nmod|sequences sequences|nmod|segments segments|nmod|END_ENTITY This pattern of selectivity might be attributable to a limited homology of a 11-amino_acid sequence with sequences within the activation segments of CPA and CPB known to interact with residues within their active sites . 8608138 5 11-amino_acid 669,682 dematin 646,653 11-amino acid dematin null 2039 Chemical Gene motif|amod|START_ENTITY shares|dobj|motif shares|nsubj|subunit subunit|nmod|END_ENTITY An alignment of the 22-amino_acid insertion sequence revealed that the 52 kDa subunit of dematin shares a novel 11-amino_acid motif with protein 4.2 . 1621096 3 11-amino_acid 353,366 EF-1_alpha 305,315 11-amino acid EF-1 alpha null 1917 Chemical Gene segment|amod|START_ENTITY contained|dobj|segment contained|nsubj|sequences sequences|compound|END_ENTITY The EF-1_alpha sequences of eukaryotes contained an 11-amino_acid segment that was also found in eocytes -LRB- extremely thermophilic , sulfur-metabolizing bacteria -RRB- but that was absent in all other bacteria . 1621096 4 11-amino_acid 610,623 EF-2 562,566 11-amino acid EF-2 null 1938 Chemical Gene insert|amod|START_ENTITY lacked|dobj|insert lacked|nsubj|genes genes|acl|encoding encoding|dobj|END_ENTITY The related -LRB- paralogous -RRB- genes encoding elongation factor EF-2 and initiation factor IF-2 also lacked the 11-amino_acid insert . 7594101 1 11-amino_acid 455,468 Fab 367,370 11-amino acid Fab null 2187 Chemical Gene peptide|amod|START_ENTITY adenosine_diphosphate|conj|peptide compare|nmod|adenosine_diphosphate describe|conj|compare describe|dobj|pharmacokinetics pharmacokinetics|nmod|END_ENTITY OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty . 7594101 1 11-amino_acid 455,468 Fab 377,380 11-amino acid Fab null 2187 Chemical Gene peptide|amod|START_ENTITY adenosine_diphosphate|conj|peptide compare|nmod|adenosine_diphosphate describe|conj|compare describe|dobj|pharmacokinetics pharmacokinetics|nmod|Fab END_ENTITY|appos|Fab OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty . 9852147 3 11-amino_acid 652,665 GalNAc-T2 587,596 11-amino acid GalNAc-T2 null 2590 Chemical Gene epitope|amod|START_ENTITY protein|conj|epitope fused|nmod|protein N-acetylgalactosaminyltransferase-2|acl|fused N-acetylgalactosaminyltransferase-2|appos|END_ENTITY To mark the Golgi in HeLa cells , we stably expressed the Golgi stack enzyme N-acetylgalactosaminyltransferase-2 -LRB- GalNAc-T2 -RRB- fused to the green fluorescent protein -LRB- GFP -RRB- or to an 11-amino_acid epitope , VSV-G -LRB- VSV -RRB- , and the trans/TGN enzyme beta1,4-galactosyltransferase -LRB- GalT -RRB- fused to GFP . 11350667 4 11-amino_acid 630,643 gp120 680,685 11-amino acid gp120 null 3700 Chemical Gene C4|amod|START_ENTITY antibodies|nmod|C4 peptide|nsubj|antibodies peptide|dep|recognize recognize|dobj|END_ENTITY Rabbit antibodies to the 11-amino_acid linear C4 peptide did not recognize gp120 in the free state or when bound to CD4 . 9746776 9 11-amino_acid 1517,1530 GPIbalpha 1425,1434 11-amino acid GPIbalpha MESH:D000596 2811 Chemical Gene region|amod|START_ENTITY binds|nmod|region shown|ccomp|binds shown|advcl|Using Using|dobj|proteases proteases|acl:relcl|cleave cleave|dobj|END_ENTITY Using proteases which cleave GPIbalpha at specific sites , we have shown that the GPIbalpha-specific antibody binds to an 11-amino_acid -LRB- 283 to 293 -RRB- region . 24444493 2 11-amino_acid 313,326 HSP27 371,376 11-amino acid HSP27 null 3315 Chemical Gene YGRKKRRQRRR|amod|START_ENTITY domain|nmod|YGRKKRRQRRR tagged|nsubjpass|domain tagged|nmod|N-terminus N-terminus|nmod|END_ENTITY The protein transduction domain -LRB- PTD -RRB- of the 11-amino_acid YGRKKRRQRRR was tagged at the N-terminus of HSP27 . 1621096 4 11-amino_acid 610,623 IF-2 589,593 11-amino acid IF-2 null 9669 Chemical Gene insert|amod|START_ENTITY lacked|dobj|insert lacked|nsubj|genes genes|acl|encoding encoding|dobj|EF-2 EF-2|conj|END_ENTITY The related -LRB- paralogous -RRB- genes encoding elongation factor EF-2 and initiation factor IF-2 also lacked the 11-amino_acid insert . 10793272 3 11-amino_acid 563,576 IGF-I 540,545 11-amino acid IGF-I null 3479 Chemical Gene epitope-tag|dep|START_ENTITY containing|dobj|epitope-tag END_ENTITY|xcomp|containing Expression vectors were created that encoded porcine IGF-I containing a T7 -LRB- 11-amino_acid -RRB- epitope-tag -LRB- TIGF -RRB- . 10202013 0 11-amino_acid 3,16 I_kappa_B_alpha 167,182 11-amino acid I kappa B alpha MESH:D000596 18035(Tax:10090) Chemical Gene sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|conj|phosphorylation phosphorylation|nmod|END_ENTITY An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest . 12763940 5 11-amino_acid 650,663 IKKbeta 745,752 11-amino acid IKKbeta MESH:D000596 3551 Chemical Gene domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|IKKgamma IKKgamma|dep|interaction interaction|compound|END_ENTITY We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation . 12763940 5 11-amino_acid 650,663 IKKgamma 729,737 11-amino acid IKKgamma MESH:D000596 8517 Chemical Gene domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|END_ENTITY We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation . 8420968 2 11-amino_acid 369,382 LAMP-1 462,468 11-amino acid LAMP-1 null 3916 Chemical Gene tail|amod|START_ENTITY terminus|nmod|tail residue|nmod|terminus constitutes|nsubj|residue constitutes|dobj|signal signal|nmod|END_ENTITY Mutagenesis and transfection experiments indicate that the motif Tyr-X-X-hydrophobic residue at the carboxyl terminus of the 11-amino_acid cytoplasmic tail of the protein constitutes the lysosomal targeting signal for LAMP-1 . 10202013 0 11-amino_acid 3,16 MAPKAP_kinase-2 131,146 11-amino acid MAPKAP kinase-2 MESH:D000596 17164(Tax:10090) Chemical Gene sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|conj|activation activation|nmod|END_ENTITY An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest . 7962070 8 11-amino_acid 1344,1357 MDGI 1311,1315 11-amino acid MDGI MESH:D000596 14077(Tax:10090) Chemical Gene sequence|amod|START_ENTITY mimicked|nmod|sequence mimicked|nsubj|properties properties|nmod|END_ENTITY Finally , the regulatory properties of MDGI can be fully mimicked by an 11-amino_acid sequence , represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs . 7962070 8 11-amino_acid 1344,1357 MDGI 1404,1408 11-amino acid MDGI MESH:D000596 14077(Tax:10090) Chemical Gene sequence|amod|START_ENTITY sequence|acl|represented represented|nmod|terminus terminus|nmod|END_ENTITY Finally , the regulatory properties of MDGI can be fully mimicked by an 11-amino_acid sequence , represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs . 9852147 3 11-amino_acid 652,665 N-acetylgalactosaminyltransferase-2 550,585 11-amino acid N-acetylgalactosaminyltransferase-2 null 79586 Chemical Gene epitope|amod|START_ENTITY protein|conj|epitope fused|nmod|protein END_ENTITY|acl|fused To mark the Golgi in HeLa cells , we stably expressed the Golgi stack enzyme N-acetylgalactosaminyltransferase-2 -LRB- GalNAc-T2 -RRB- fused to the green fluorescent protein -LRB- GFP -RRB- or to an 11-amino_acid epitope , VSV-G -LRB- VSV -RRB- , and the trans/TGN enzyme beta1,4-galactosyltransferase -LRB- GalT -RRB- fused to GFP . 12763940 5 11-amino_acid 650,663 NEMO 739,743 11-amino acid NEMO MESH:D000596 8517 Chemical Gene domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|IKKgamma IKKgamma|appos|END_ENTITY We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation . 12763940 5 11-amino_acid 650,663 NF-kappaB 777,786 11-amino acid NF-kappaB MESH:D000596 4790 Chemical Gene domain|amod|START_ENTITY used|dobj|domain used|advcl|preventing preventing|dobj|activation activation|amod|END_ENTITY We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation . 22982609 2 11-amino_acid 435,448 PACAP 406,411 11-amino acid PACAP null 11516(Tax:10090) Chemical Gene domain|amod|START_ENTITY tagging|nmod|domain tagging|dobj|END_ENTITY In order to increase the efficiency of traversing biological barriers , a novel fusion peptide PACAP-TAT was produced by tagging PACAP at its C-terminus with 11-amino_acid TAT protein transduction domain . 14662773 11 11-amino_acid 1978,1991 profilin_I 2081,2091 11-amino acid profilin I MESH:D000596 5216 Chemical Gene motifs|amod|START_ENTITY motifs|acl:relcl|similar similar|nmod|site site|nmod|END_ENTITY The actin binding activities of the B subunits of V-ATPase required 11-amino_acid actin-binding motifs that are similar in sequence to the actin-binding site of mammalian profilin_I . 14662773 5 11-amino_acid 1072,1085 profilin_I 1153,1163 11-amino acid profilin I MESH:D000596 5216 Chemical Gene segment|amod|START_ENTITY segment|nmod|sequence sequence|amod|similar similar|nmod|site site|nmod|END_ENTITY An 11-amino_acid segment with a sequence similar to the actin-binding site of human profilin_I was detected within this region . 11560935 6 11-amino_acid 947,960 Ras-GRF1 1107,1115 11-amino acid Ras-GRF1 null 5923 Chemical Gene segment|amod|START_ENTITY segment|nmod|domains domains|nmod|regions regions|dep|828-838 828-838|nmod|Sos1 Sos1|conj|1057-1067 1057-1067|nmod|END_ENTITY Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors . 11560935 6 11-amino_acid 947,960 Ras-GRF1 882,890 11-amino acid Ras-GRF1 null 5923 Chemical Gene segment|amod|START_ENTITY reside|nmod|segment revealed|ccomp|reside revealed|nsubj|Analysis Analysis|nmod|chimeras chimeras|conj|exchanges exchanges|nmod|Sos1 Sos1|conj|END_ENTITY Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors . 11560935 6 11-amino_acid 947,960 Sos1 1085,1089 11-amino acid Sos1 null 6654 Chemical Gene segment|amod|START_ENTITY segment|nmod|domains domains|nmod|regions regions|dep|828-838 828-838|nmod|END_ENTITY Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors . 11560935 6 11-amino_acid 947,960 Sos1 873,877 11-amino acid Sos1 null 6654 Chemical Gene segment|amod|START_ENTITY reside|nmod|segment revealed|ccomp|reside revealed|nsubj|Analysis Analysis|nmod|chimeras chimeras|conj|exchanges exchanges|nmod|END_ENTITY Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors . 7536738 2 11-amino_acid 414,427 substance_P 458,469 11-amino acid substance P null 21333(Tax:10090) Chemical Gene D-Arg1|amod|START_ENTITY D-Arg1|appos|peptide peptide|compound|END_ENTITY Incubation of Swiss_3T3 fibroblasts with the 11-amino_acid -LSB- D-Arg1 , D-Phe5 , D-Trp7 ,9 , Leu11 -RSB- substance_P peptide inhibited bombesin-stimulated cell proliferation and phospholipase C beta activation even at high bombesin concentrations . 18325388 1 11-amino_acid 86,99 Substance_P 63,74 11-amino acid Substance P MESH:D000596 21333(Tax:10090) Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|_ _|compound|END_ENTITY BACKGROUND _ AIMS : Substance_P _ -LRB- SP -RRB- is an 11-amino_acid peptide that belongs to the tachykinin family of peptides . 8342042 4 11-amino_acid 580,593 TAP1 513,517 11-amino acid TAP1 MESH:D000596 6890 Chemical Gene peptide|amod|START_ENTITY delivery|nmod|peptide resulted|nmod|delivery resulted|nsubj|Expression Expression|nmod|END_ENTITY Expression of TAP1 and TAP2 in a mutant cell line resulted in the delivery of an 11-amino_acid oligomer model peptide to the ER . 8342042 4 11-amino_acid 580,593 TAP2 522,526 11-amino acid TAP2 MESH:D000596 6891 Chemical Gene peptide|amod|START_ENTITY delivery|nmod|peptide resulted|nmod|delivery resulted|nsubj|Expression Expression|nmod|TAP1 TAP1|conj|END_ENTITY Expression of TAP1 and TAP2 in a mutant cell line resulted in the delivery of an 11-amino_acid oligomer model peptide to the ER . 16390270 2 11-amino_acid 416,429 Tat11 516,521 11-amino acid Tat11 null 6741294(Tax:353154) Chemical Gene peptide|amod|START_ENTITY peptide|nmod|domain domain|nmod|protein protein|appos|END_ENTITY We have shown that fusion of TK to an 11-amino_acid peptide from the basic domain of the human_immunodeficiency_virus_type_1 Tat protein -LRB- Tat11 -RRB- imparts cell membrane-translocating ability to the enzyme and significantly increases its cytotoxic activity . 7594101 1 11-amino_acid 455,468 thrombin 469,477 11-amino acid thrombin null 2147 Chemical Gene peptide|amod|START_ENTITY peptide|amod|END_ENTITY OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty . 10893266 4 11-amino_acid 629,642 Tiam1 687,692 11-amino acid Tiam1 null 7074 Chemical Gene sequence|amod|START_ENTITY sequence|nmod|amino_acids amino_acids|nmod|END_ENTITY Biochemical studies and deletion mutation analyses indicate that the 11-amino_acid sequence between amino_acids 717 and 727 of Tiam1 -LRB- -LRB- 717 -RRB- GEGTDAVKRS -LRB- 727 -RRB- L -RRB- is the ankyrin-binding domain . 11054635 5 11-amino_acid 733,746 TR_beta 802,809 11-amino acid TR beta null 6957 Chemical Gene deletion|amod|START_ENTITY had|nsubj|deletion had|dobj|potency potency|nmod|END_ENTITY Previously , we found beta F451X with carboxyl -LRB- C -RRB- - terminal 11-amino_acid deletion had stronger silencing potency than wild-type TR_beta 1 and beta E449X with C-terminal 13-amino_acid deletion on a subset of TREs . 8393816 11 11-amino-acid 1709,1722 agrin 1768,1773 11-amino-acid agrin null 396538(Tax:9031) Chemical Gene results|amod|START_ENTITY results|nmod|expression expression|nmod|transcripts transcripts|compound|END_ENTITY Alternative splicing of both the 8 - and the 11-amino-acid exons results in expression of four distinct agrin transcripts in the ganglion . 7557400 3 11-amino-acid 731,744 alpha-tubulin 874,887 11-amino-acid alpha-tubulin null 10376 Chemical Gene sequence|amod|START_ENTITY correspond|nmod|sequence correspond|conj|recognised recognised|nmod|END_ENTITY The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin . 20345279 6 11-amino-acid 879,892 beta-glucuronidase 948,966 11-amino-acid beta-glucuronidase null 2990 Chemical Gene virus|amod|START_ENTITY virus|acl:relcl|fused fused|xcomp|END_ENTITY Second , we used the 11-amino-acid human immunodeficiency virus -LRB- HIV -RRB- Tat domain fused to beta-glucuronidase to mediate uptake by absorptive endocytosis . 8690094 7 11-amino-acid 1047,1060 BPTI 947,951 11-amino-acid BPTI null 404103(Tax:9913) Chemical Gene pVIc|amod|START_ENTITY complexed|nmod|pVIc proteinase|acl|complexed inhibitor|nmod|proteinase acts|nmod|inhibitor acts|nsubj|END_ENTITY In vitro with purified components , BPTI acts as a competitive inhibitor -LRB- Ki 2 microM -RRB- of the recombinant proteinase complexed with its 11-amino-acid cofactor pVIc . 16600177 2 11-amino-acid 261,274 C4beta 370,376 11-amino-acid C4beta null 721 Chemical Gene has|nsubj|START_ENTITY has|dobj|homology homology|nmod|sequence sequence|nmod|chain chain|amod|END_ENTITY The C-terminal 11-amino-acid of the first CRIT-extracellular domain -LRB- CRIT-H17 -RRB- has a strong homology with a sequence in the C4beta chain , which is responsible for the binding of C2 . 12166660 2 11-amino-acid 350,363 CEL 289,292 11-amino-acid CEL null 1056 Chemical Gene motif|amod|START_ENTITY sequence|nmod|motif contain|dobj|sequence contain|nsubj|END_ENTITY The gene encoding CEL was known to contain a tandemly repeated sequence of the 11-amino-acid motif in the C-terminal region . 8380082 4 11-amino-acid 674,687 CLP 620,623 11-amino-acid CLP null 810 Chemical Gene sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant prevented|dobj|formation formation|compound|END_ENTITY Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation . 10485712 5 11-amino-acid 896,909 ClpA 796,800 11-amino-acid ClpA null 50945 Chemical Gene recognition|amod|START_ENTITY added|dobj|recognition stable|advcl|added peptide|amod|stable test|nmod|peptide test|dobj|action action|nmod|END_ENTITY Here we test the action of ClpA on a stable monomeric protein , the green fluorescent protein GFP , onto which has been added an 11-amino-acid carboxy-terminal recognition peptide , which is responsible for recruiting truncated proteins to ClpAP for degradation . 7557400 3 11-amino-acid 731,744 c-myc 765,770 11-amino-acid c-myc null 4609 Chemical Gene sequence|amod|START_ENTITY correspond|nmod|sequence correspond|nmod|END_ENTITY The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin . 9714840 4 11-amino-acid 548,561 Cre 494,497 11-amino-acid Cre null 2777477(Tax:10678) Chemical Gene epitope_to_the_herpes_simplex_virus|amod|START_ENTITY terminus|nmod|epitope_to_the_herpes_simplex_virus 1989|amod|terminus tagged|nmod|1989 tagged|nsubjpass|protein protein|compound|END_ENTITY We have constructed an expression vector wherein the Cre protein is tagged at the carboxy terminus with an 11-amino-acid epitope_to_the_herpes_simplex_virus -LRB- HSV -RRB- glycoprotein D coat protein -LRB- Isola , V.J. , Eisenberg , R.J. , Siebert , G.R. , Heilman , C.J. , Wilcox , W.C. , Cohan , G.H. , 1989 . 19451286 7 11-amino-acid 1170,1183 CyPA 1237,1241 11-amino-acid CyPA null 5478 Chemical Gene peptide|amod|START_ENTITY peptide|acl|known known|xcomp|block block|dobj|activity activity|nmod|END_ENTITY Furthermore , antiviral experiments demonstrated that cyclosporine -LRB- Cs ; an 11-amino-acid cyclic peptide known to block the PPIase activity of CyPA -RRB- inhibits flavivirus replication in cell culture at nontoxic concentrations . 15823096 10 11-amino-acid 1384,1397 ed1 1331,1334 11-amino-acid ed1 null 1896 Chemical Gene fragment|amod|START_ENTITY vWFA|nmod|fragment vWFA|acl|bound bound|dobj|peptide peptide|amod|END_ENTITY vWFA bound the ed1 peptide of CRIT as well , and specifically to the 11-amino-acid peptide fragment of ed1 that is known to interact with whole C2 . 15823096 10 11-amino-acid 1384,1397 ed1 1418,1421 11-amino-acid ed1 null 1896 Chemical Gene fragment|amod|START_ENTITY vWFA|nmod|fragment vWFA|nmod|END_ENTITY vWFA bound the ed1 peptide of CRIT as well , and specifically to the 11-amino-acid peptide fragment of ed1 that is known to interact with whole C2 . 27577911 1 11-amino-acid 241,254 endostatin 294,304 11-amino-acid endostatin null 564123(Tax:7955) Chemical Gene peptide|amod|START_ENTITY peptide|acl|derived derived|nmod|terminus terminus|nmod|END_ENTITY Soluble O - -LRB- 2-hydroxyl -RRB- propyl-3-trimethyl_ammonium_chitooligosaccharide_chloride -LRB- HTCOSC -RRB- was covalently conjugated to the 11-amino-acid peptide derived from amino terminus of endostatin -LRB- endostatin2 , ES2 , IVRRADRAAVP -RRB- to overcome its poor stability , low cell affinity and instable activity . 9506920 2 11-amino-acid 404,417 FPR 321,324 11-amino-acid FPR null 2357 Chemical Gene corresponding|amod|START_ENTITY directed|nmod|corresponding antiserum|acl|directed produced|nsubjpass|antiserum cloned|conj|produced cloned|nsubjpass|cDNA cDNA|nmod|END_ENTITY The cDNA for human FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptide corresponding to the deduced carboxy-terminus has been produced . 15994797 6 11-amino-acid 1063,1076 Gag 1118,1121 11-amino-acid Gag null 1491923(Tax:11886) Chemical Gene sequence|amod|START_ENTITY sequence|nmod|END_ENTITY One exception was the 11-amino-acid p2b sequence of Rous_sarcoma_virus _ -LRB- RSV -RRB- Gag , which could fully restore HIV-1 budding , while a PPPPY sequence exchange alone did not . 24406899 2 11-amino-acid 457,470 GDNF 314,318 11-amino-acid GDNF null 2668 Chemical Gene peptide|amod|START_ENTITY smaller|nmod|peptide formation|nmod|smaller theorizes|dobj|formation theorizes|nsubj|model model|nmod|proprotein proprotein|compound|END_ENTITY A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller , amidated peptide -LRB- s -RRB- from the proregion that exhibit neurobiological function , including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 -LRB- DNSP-11 -RRB- . 14500468 1 11-amino-acid 213,226 glycoprotein_D 238,252 11-amino-acid glycoprotein D null 2532 Chemical Gene peptide|amod|START_ENTITY peptide|nmod|END_ENTITY The potential of the major structural protein DraE of Escherichia_coli Dr fimbriae has been used to display an 11-amino-acid peptide of glycoprotein_D derived from herpes_simplex_virus -LRB- HSV -RRB- type 1 . 14500468 2 11-amino-acid 436,449 glycoprotein_D 353,367 11-amino-acid glycoprotein D null 2532 Chemical Gene sequence|amod|START_ENTITY place|nmod|sequence gene|nmod|place inserted|nmod|gene inserted|nsubjpass|sequence sequence|acl|mimicking mimicking|nmod|END_ENTITY The heterologous sequence mimicking an epitope from glycoprotein_D was inserted in one copy into the draE gene in place of a predicted 11-amino-acid sequence in the N-terminal region of surface-exposed domain 2 within the conserved disulfide loop -LRB- from Cys21 to Cys53 -RRB- . 14500468 4 11-amino-acid 899,912 glycoprotein_D 928,942 11-amino-acid glycoprotein D null 2532 Chemical Gene epitope|amod|START_ENTITY END_ENTITY|nsubj|epitope Conversely , immunization of rabbits with purified chimeric Dr-HSV fimbriae resulted in a serum that specifically recognized the 11-amino-acid epitope of HSV glycoprotein_D , indicating the utility of the strategy employed . 14693913 4 11-amino-acid 888,901 hBSSL 862,867 11-amino-acid hBSSL null 1056 Chemical Gene repeats|amod|START_ENTITY contain|dobj|repeats contain|nsubj|residues residues|nmod|END_ENTITY The C-terminal 192 residues of hBSSL contain 16 Pro-rich 11-amino-acid repeats , which include 32 Ser/Thr residues as potential O-glycosylation sites . 28125988 4 11-amino-acid 402,415 hepatocyte_growth_factor 436,460 11-amino-acid hepatocyte growth factor null 24446(Tax:10116) Chemical Gene peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|END_ENTITY We identified an 11-amino-acid peptide , H-RN , from hepatocyte_growth_factor -LRB- HGF -RRB- , an endogenous protein with anti-inflammatory properties . 28125988 4 11-amino-acid 402,415 HGF 462,465 11-amino-acid HGF null 24446(Tax:10116) Chemical Gene peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|hepatocyte_growth_factor hepatocyte_growth_factor|appos|END_ENTITY We identified an 11-amino-acid peptide , H-RN , from hepatocyte_growth_factor -LRB- HGF -RRB- , an endogenous protein with anti-inflammatory properties . 26191773 3 11-amino-acid 532,545 IkBa 607,611 11-amino-acid IkBa null 4792 Chemical Gene sequence|amod|START_ENTITY sequence|acl:relcl|sufficient sufficient|conj|required required|nmod|half-life half-life|nmod:poss|END_ENTITY The ubiquitin-independent degradation signal resides in an 11-amino-acid sequence , which is not only sufficient but also required for IkBa 's short half-life . 9811606 6 11-amino-acid 1167,1180 interleukin-2_receptor_alpha 1130,1158 11-amino-acid interleukin-2 receptor alpha null 3559 Chemical Gene region|amod|START_ENTITY END_ENTITY|nmod|region This motif acts as an internalization signal in the context of a CD8-Nef chimera or in a fusion of the interleukin-2_receptor_alpha with an 11-amino-acid region from Nef containing the dileucine motif . 9513711 9 11-amino-acid 1370,1383 MDGI 1409,1413 11-amino-acid MDGI null 14077(Tax:10090) Chemical Gene peptide|amod|START_ENTITY mimic|nsubj|peptide mimic|dobj|activity activity|compound|END_ENTITY An MDGI-derived C-terminal 11-amino-acid peptide is able to mimic MDGI activity in vitro . 9811606 6 11-amino-acid 1167,1180 Nef 1193,1196 11-amino-acid Nef null 156110(Tax:11676) Chemical Gene region|amod|START_ENTITY region|nmod|END_ENTITY This motif acts as an internalization signal in the context of a CD8-Nef chimera or in a fusion of the interleukin-2_receptor_alpha with an 11-amino-acid region from Nef containing the dileucine motif . 7856096 4 11-amino-acid 429,442 ORF1 402,406 11-amino-acid ORF1 null 55354 Chemical Gene epitope|amod|START_ENTITY inserted|nsubjpass|epitope inserted|advcl|determine determine|ccomp|encodes encodes|nsubj|END_ENTITY To determine whether ORF1 encodes a protein , an 11-amino-acid epitope was inserted in frame after the ninth codon of the ORF1 open reading frame . 7856096 4 11-amino-acid 429,442 ORF1 502,506 11-amino-acid ORF1 null 55354 Chemical Gene epitope|amod|START_ENTITY inserted|nsubjpass|epitope inserted|nmod|codon codon|nmod|frame frame|compound|END_ENTITY To determine whether ORF1 encodes a protein , an 11-amino-acid epitope was inserted in frame after the ninth codon of the ORF1 open reading frame . 27707926 15 11-amino-acid 2205,2218 p12 2163,2166 11-amino-acid p12 null 69745(Tax:10090) Chemical Gene motif|amod|START_ENTITY identified|nmod|motif identified|nsubjpass|tethering tethering|amod|END_ENTITY Maximal p12 tethering was identified with only an 11-amino-acid minimal chromatin tethering motif encoded at p1261-71 Within this region , the p12-M63I substitution switches p12 into a tethering-competent state , partially rescuing the p12-PM15 tethering mutant . 27707926 15 11-amino-acid 2205,2218 p12 2328,2331 11-amino-acid p12 null 69745(Tax:10090) Chemical Gene motif|amod|START_ENTITY motif|acl|encoded encoded|nmod|p1261-71 p1261-71|acl:relcl|switches switches|dobj|END_ENTITY Maximal p12 tethering was identified with only an 11-amino-acid minimal chromatin tethering motif encoded at p1261-71 Within this region , the p12-M63I substitution switches p12 into a tethering-competent state , partially rescuing the p12-PM15 tethering mutant . 9510558 6 11-amino-acid 1019,1032 p193 1068,1072 11-amino-acid p193 null 143 Chemical Gene sequence|amod|START_ENTITY induced|ccomp|sequence induced|conj|located located|nmod|END_ENTITY The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 - 203 -LRB- E-I-W-R-D-I-D-F-A-H-E -RRB- . 23652276 3 11-amino-acid 450,463 P2_and_P4 515,524 11-amino-acid P2 and P4 null 201780 Chemical Gene peptide|amod|START_ENTITY N-terminus|conj|peptide N-terminus|conj|two two|acl|designed designed|ccomp|generated generated|nsubjpass|peptides peptides|appos|END_ENTITY In this study , Inhibitor2 , a heptapeptide MMP inhibitor , was connected to the N-terminus or C-terminus of ES-2 , an 11-amino-acid antiangiogenic peptide , and two designed peptides , P2_and_P4 , were generated . 2963808 4 11-amino-acid 512,525 P-450 581,586 11-amino-acid P-450 null 1555 Chemical Gene sequence|amod|START_ENTITY human-2|nsubj|sequence human-2|nmod|agreement agreement|nmod|sequence sequence|nmod|END_ENTITY The N-terminal 11-amino-acid sequence was in agreement with the protein sequence of P-450 human-2 . 17610503 3 11-amino-acid 887,900 p53 1047,1050 11-amino-acid p53 null 7157 Chemical Gene region|amod|START_ENTITY fusion|nmod|region TAT|nsubj|fusion TAT|dep|increases increases|dobj|solubility solubility|nmod|protein protein|compound|END_ENTITY Here , we show that fusion of an 11-amino-acid region of the human immunodeficiency virus TAT protein transduction domain -LRB- PTD -RRB- to human p53 increases the solubility of the otherwise insoluble p53 protein and this rTAT-p53 protein can be transduced into human monocyte-derived dendritic cells -LRB- DCs -RRB- . 17610503 3 11-amino-acid 887,900 p53 991,994 11-amino-acid p53 null 7157 Chemical Gene region|amod|START_ENTITY fusion|nmod|region TAT|nsubj|fusion TAT|dep|increases increases|nsubj|domain domain|nmod|END_ENTITY Here , we show that fusion of an 11-amino-acid region of the human immunodeficiency virus TAT protein transduction domain -LRB- PTD -RRB- to human p53 increases the solubility of the otherwise insoluble p53 protein and this rTAT-p53 protein can be transduced into human monocyte-derived dendritic cells -LRB- DCs -RRB- . 8384581 3 11-amino-acid 540,553 PP-1_alpha 451,461 11-amino-acid PP-1 alpha null 5499 Chemical Gene insert|amod|START_ENTITY PP-1_alpha|nmod|insert differs|nmod|PP-1_alpha subunit|acl:relcl|differs subunit|dep|2 2|compound|END_ENTITY One clone encodes a novel type 1 protein phosphatase catalytic subunit -LRB- PP-1_alpha 2 -RRB- , which differs from the originally defined PP-1_alpha by an amino-terminal 11-amino-acid insert . 8384581 3 11-amino-acid 540,553 PP-1_alpha 508,518 11-amino-acid PP-1 alpha null 5499 Chemical Gene insert|amod|START_ENTITY END_ENTITY|nmod|insert One clone encodes a novel type 1 protein phosphatase catalytic subunit -LRB- PP-1_alpha 2 -RRB- , which differs from the originally defined PP-1_alpha by an amino-terminal 11-amino-acid insert . 8690094 7 11-amino-acid 1047,1060 proteinase 1017,1027 11-amino-acid proteinase null 100862683 Chemical Gene pVIc|amod|START_ENTITY complexed|nmod|pVIc END_ENTITY|acl|complexed In vitro with purified components , BPTI acts as a competitive inhibitor -LRB- Ki 2 microM -RRB- of the recombinant proteinase complexed with its 11-amino-acid cofactor pVIc . 18705864 8 11-amino-acid 1268,1281 RPP13 1310,1315 11-amino-acid RPP13 null 823806(Tax:3702) Chemical Gene units|amod|START_ENTITY variation|nmod|units affect|nsubj|variation affect|dobj|recognition recognition|compound|END_ENTITY The extensive variation in the 11-amino-acid repeat units did not affect RPP13 recognition . 9651500 3 11-amino-acid 604,617 sTnT 587,591 11-amino-acid sTnT null 7138 Chemical Gene segment|amod|START_ENTITY encoding|dobj|segment found|xcomp|encoding found|nmod|END_ENTITY Together with a 5 ' - alternative exon that was also found in human sTnT encoding an 11-amino-acid acidic segment , the results revealed a novel alternative splicing pathway to include or exclude a three-base segment to generate additional sTnT isoforms with NH2-terminal charge variations . 9651500 3 11-amino-acid 604,617 sTnT 758,762 11-amino-acid sTnT null 7138 Chemical Gene segment|amod|START_ENTITY encoding|dobj|segment found|xcomp|encoding exon|acl:relcl|found 5|dep|exon Together|nmod|5 revealed|advmod|Together revealed|dobj|alternative alternative|acl|splicing splicing|xcomp|include include|advcl|generate generate|dobj|isoforms isoforms|compound|END_ENTITY Together with a 5 ' - alternative exon that was also found in human sTnT encoding an 11-amino-acid acidic segment , the results revealed a novel alternative splicing pathway to include or exclude a three-base segment to generate additional sTnT isoforms with NH2-terminal charge variations . 22210023 2 11-amino-acid 378,391 substance-P 357,368 11-amino-acid substance-P null 6863 Chemical Gene peptide|amod|START_ENTITY _|appos|peptide _|amod|END_ENTITY In this report , we introduce a novel function of substance-P _ -LRB- SP -RRB- , an 11-amino-acid peptide , as an injury-inducible messenger to mobilize bone marrow stem cells to the blood and finally to engage in tissue repair . 1696081 1 11-amino-acid 69,82 Substance_P 46,57 11-amino-acid Substance P null 6863 Chemical Gene neuropeptide|amod|START_ENTITY neuropeptide|nsubj|_ _|compound|END_ENTITY Substance_P _ -LRB- SP -RRB- is an 11-amino-acid neuropeptide found in sensory neurons in the peripheral nervous system . 9436358 4 11-amino-acid 670,683 Substance_P 616,627 11-amino-acid Substance P null 6863 Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY Substance_P , a member of the tachykinin family , is an 11-amino-acid peptide . 12489030 3 11-amino-acid 487,500 Tat11 557,562 11-amino-acid Tat11 null 6741294(Tax:353154) Chemical Gene peptide|amod|START_ENTITY TK|nmod|peptide fusion|nmod|TK imparts|nsubj|fusion imparts|dep|END_ENTITY Here we report that fusion of TK to an 11-amino-acid peptide from the basic domain of the HIV-1 Tat protein -LRB- Tat11 -RRB- imparts cell membrane translocating ability to the enzyme and significantly increases its cytotoxic efficacy . 7935437 7 11-amino-acid 1145,1158 TATA-binding_protein 1209,1229 11-amino-acid TATA-binding protein null 6908 Chemical Gene module|amod|START_ENTITY forms|nmod|module bound|nsubj|forms bound|nmod|TFIIB TFIIB|conj|END_ENTITY While dimeric forms of the 11-amino-acid acidic activation module bound to either TFIIB or TATA-binding_protein efficiently in vitro , a similarly charged peptide lacking the core phenylalanine residue failed to interact . 12489030 0 11-amino-acid 71,84 thymidine_kinase 39,55 11-amino-acid thymidine kinase null 24271467 Chemical Gene peptide|amod|START_ENTITY mediated|nmod|peptide mediated|nsubj|transfer transfer|nmod|END_ENTITY Transcellular transfer of active HSV-1 thymidine_kinase mediated by an 11-amino-acid peptide from HIV-1 Tat . 9596755 2 11-amino-acid 312,325 TNF 274,277 11-amino-acid TNF null 21926(Tax:10090) Chemical Gene site|amod|START_ENTITY consisting|nmod|site peptide|acl|consisting peptide|compound|END_ENTITY Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically . 9596755 2 11-amino-acid 312,325 TNF 326,329 11-amino-acid TNF null 21926(Tax:10090) Chemical Gene site|amod|START_ENTITY site|compound|END_ENTITY Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically . 9596755 2 11-amino-acid 312,325 TNF 427,430 11-amino-acid TNF null 21926(Tax:10090) Chemical Gene site|amod|START_ENTITY consisting|nmod|site peptide|acl|consisting possess|nsubj|peptide possess|dobj|many many|nmod|properties properties|nmod|END_ENTITY Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically . 9510558 6 11-amino-acid 1019,1032 tyrosinase 1057,1067 11-amino-acid tyrosinase null 7299 Chemical Gene sequence|amod|START_ENTITY induced|ccomp|sequence induced|conj|located located|nmod|p193 p193|amod|END_ENTITY The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 - 203 -LRB- E-I-W-R-D-I-D-F-A-H-E -RRB- . 19099499 4 11-amino-acid 653,666 U11 682,685 11-amino-acid U11 null 26824 Chemical Gene sequence|amod|START_ENTITY sequence|acl|named named|dobj|peptide peptide|nummod|END_ENTITY Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle . 19099499 4 11-amino-acid 653,666 U11 734,737 11-amino-acid U11 null 26824 Chemical Gene sequence|amod|START_ENTITY sequence|acl|named named|dobj|peptide peptide|acl|modified modified|xcomp|form form|xcomp|peptide-lipid peptide-lipid|nsubj|amphiphile.This amphiphile.This|nummod|END_ENTITY Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle . 19099499 4 11-amino-acid 653,666 U11 877,880 11-amino-acid U11 null 26824 Chemical Gene sequence|amod|START_ENTITY consisting|nmod|sequence ligand|xcomp|consisting targeting|dep|ligand uPAR|acl|targeting synthesis|nmod|uPAR derive|nsubj|synthesis derive|dobj|nanoparticle nanoparticle|compound|END_ENTITY Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle . 19680632 1 11-amino-acid 104,117 U-II 92,96 11-amino-acid U-II null 10911 Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|urotensin-II urotensin-II|appos|END_ENTITY Human urotensin-II -LRB- U-II -RRB- is an 11-amino-acid cyclic peptide that activates a G -LRB- q -RRB- - coupled receptor named UT . 19099499 4 11-amino-acid 653,666 uPAR 614,618 11-amino-acid uPAR null 5329 Chemical Gene sequence|amod|START_ENTITY consisting|nmod|sequence ligand|xcomp|consisting targeting|dep|ligand END_ENTITY|acl|targeting Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle . 19680632 1 11-amino-acid 104,117 urotensin-II 78,90 11-amino-acid urotensin-II null 10911 Chemical Gene peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY Human urotensin-II -LRB- U-II -RRB- is an 11-amino-acid cyclic peptide that activates a G -LRB- q -RRB- - coupled receptor named UT . 8380082 4 11-amino-acid 674,687 VP7 589,592 11-amino-acid VP7 null 2943155(Tax:40051) Chemical Gene sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant terminus|acl|prevented terminus|nummod|END_ENTITY Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation . 8380082 4 11-amino-acid 674,687 VP7 741,744 11-amino-acid VP7 null 2943155(Tax:40051) Chemical Gene sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant terminus|acl|prevented mutants|nmod|terminus added|nsubj|mutants added|nmod|terminus terminus|nmod|formation formation|nummod|END_ENTITY Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation . 7557400 3 11-amino-acid 731,744 YL1/2 865,870 11-amino-acid YL1/2 null 6944 Chemical Gene sequence|amod|START_ENTITY correspond|nmod|sequence correspond|conj|recognised recognised|nmod|END_ENTITY The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin . 19035465 4 11-amino_acid_peptide 475,496 KV11 504,508 11-amino acid peptide KV11 MESH:D000602 3736 Chemical Gene START_ENTITY|dep|named named|dobj|END_ENTITY Here , we identified an 11-amino_acid_peptide -LRB- named KV11 -RRB- as the key region for the antiangiogenic function of the KV domain of apolipoprotein -LRB- a -RRB- . 14769036 3 11-amino_acid_peptide 543,564 PKB 631,634 11-amino acid peptide PKB MESH:D000602 2185 Chemical Gene was|nsubj|START_ENTITY was|advmod|efficiently efficiently|dep|phosphorylated phosphorylated|nmod|protein_kinase_B protein_kinase_B|appos|END_ENTITY We utilized a quantitative , single-cell assay to demonstrate that an 11-amino_acid_peptide was efficiently phosphorylated by intracellular protein_kinase_B -LRB- PKB -RRB- in fibrosarcoma cell line HT1080 and in NIH-3T3 cells . 14769036 3 11-amino_acid_peptide 543,564 protein_kinase_B 613,629 11-amino acid peptide protein kinase B MESH:D000602 2185 Chemical Gene was|nsubj|START_ENTITY was|advmod|efficiently efficiently|dep|phosphorylated phosphorylated|nmod|END_ENTITY We utilized a quantitative , single-cell assay to demonstrate that an 11-amino_acid_peptide was efficiently phosphorylated by intracellular protein_kinase_B -LRB- PKB -RRB- in fibrosarcoma cell line HT1080 and in NIH-3T3 cells . 12966076 3 11-amino_acid_peptide 868,889 rhodopsin 1037,1046 11-amino acid peptide rhodopsin MESH:D000602 6010 Chemical Gene START_ENTITY|nmod|alpha-subunit alpha-subunit|nmod|Gt Gt|acl|suggesting suggesting|ccomp|plays plays|nmod|interaction interaction|nmod|intermediates intermediates|compound|END_ENTITY Here we demonstrate that the interactions of Gt with these intermediates in the absence of GTPgammaS can be mimicked by the C-terminus 11-amino_acid_peptide -LRB- 340-350 -RRB- of the alpha-subunit of Gt -LRB- Gt -LRB- alpha -RRB- -RRB- , suggesting that the C-terminal region of Gt -LRB- alpha -RRB- plays important roles in the interaction with rhodopsin intermediates . 8487866 6 11-amino-acid_peptide 886,907 rhodopsin 984,993 11-amino-acid peptide rhodopsin MESH:D000602 6010 Chemical Gene terminus|amod|START_ENTITY END_ENTITY|nsubj|terminus An 11-amino-acid_peptide from the C terminus of the alpha-subunit of Gt -LRB- alpha t -LRB- 340-350 -RRB- -RRB- binds to rhodopsin and mimics the G protein in stabilizing its active form , metarhodopsin_II . 25446075 3 11-amino-acids 618,632 Pak1 665,669 11-amino-acids Pak1 null 18479(Tax:10090) Chemical Gene peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|domain domain|nmod|END_ENTITY Here , we identified 11-amino-acids peptide within kinase domain of Pak1 , necessary and sufficient for SKIP binding . 25446075 3 11-amino-acids 618,632 SKIP 700,704 11-amino-acids SKIP null 19062(Tax:10090) Chemical Gene peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|binding binding|compound|END_ENTITY Here , we identified 11-amino-acids peptide within kinase domain of Pak1 , necessary and sufficient for SKIP binding . 10482456 3 11-aminobenzoquinolizidines 440,467 acetylcholinesterase 396,416 11-aminobenzoquinolizidines acetylcholinesterase null 43 Chemical Gene employing|xcomp|START_ENTITY produce|advcl|employing produce|dobj|inhibitor inhibitor|amod|END_ENTITY The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines -LRB- 4 -RRB- and 10-aminobenzoindolizidines -LRB- 5 -RRB- as templates . 12868745 0 11-aminoundecanethiol 78,99 glucose_oxidase 39,54 11-aminoundecanethiol glucose oxidase null 54363 Chemical Gene monolayers|amod|START_ENTITY attached|nmod|monolayers attached|nsubj|formation formation|nmod|covalently covalently|amod|END_ENTITY Self-assembling monolayer formation of glucose_oxidase covalently attached on 11-aminoundecanethiol monolayers on gold . 27035762 2 11-aminoundecanoic_acid 427,450 CD_1a 561,566 11-aminoundecanoic acid CD 1a MESH:C023820 909 Chemical Gene Na-salt|advcl|START_ENTITY glycine|conj|Na-salt Na-salt|acl|glycine produce|nsubj|Na-salt produce|dobj|1s 1s|conj|END_ENTITY Citric_acid was used as the source of the carbon core , and Na-salt of glycine , glycine , Na-salt of 11-aminoundecanoic_acid , 11-aminoundecanoic_acid , and n-hexadecylamine were used for the surface fabrication of CDs to produce CD 1s , CD_1a , CD_2s , CD_2a , and CD 3 , respectively . 27035762 2 11-aminoundecanoic_acid 452,475 CD_1a 561,566 11-aminoundecanoic acid CD 1a MESH:C023820 909 Chemical Gene glycine|conj|START_ENTITY Na-salt|acl|glycine produce|nsubj|Na-salt produce|dobj|1s 1s|conj|END_ENTITY Citric_acid was used as the source of the carbon core , and Na-salt of glycine , glycine , Na-salt of 11-aminoundecanoic_acid , 11-aminoundecanoic_acid , and n-hexadecylamine were used for the surface fabrication of CDs to produce CD 1s , CD_1a , CD_2s , CD_2a , and CD 3 , respectively . 27634443 3 11-amnio_acid 451,464 EPO 521,524 11-amnio acid EPO null 2056 Chemical Gene sequence|amod|START_ENTITY sequence|acl|derived derived|nmod|B B|nmod|END_ENTITY Helix B surface peptide -LRB- HBSP -RRB- , a 11-amnio_acid sequence derived from the non-erythropoietic helix B of EPO , not only shows higher affinity to TPR but also plays a more specific and powerful role in tissue protection without erythropoietic side-effects . 19052845 7 11Arg 947,952 ADAMTS9 884,891 11Arg ADAMTS9 null 56999 Chemical Gene inhibitors|conj|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|expression expression|compound|END_ENTITY The IL-1_beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors , FK506 and 11Arg -LRB- 11R -RRB- - VIVIT . 19052845 7 11Arg 947,952 IL-1_beta 864,873 11Arg IL-1 beta null 3553 Chemical Gene inhibitors|conj|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|expression expression|amod|inducible inducible|amod|END_ENTITY The IL-1_beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors , FK506 and 11Arg -LRB- 11R -RRB- - VIVIT . 11301332 5 11-azidophenyl_agosterol_A 618,644 MRP1 751,755 11-azidophenyl agosterol A MRP1 MESH:C429345 4363 Chemical Gene -RSB-|xcomp|START_ENTITY -RSB-|xcomp|photolabel photolabel|dobj|END_ENTITY We synthesized -LSB- -LRB- 125 -RRB- I -RSB- 11-azidophenyl_agosterol_A -LRB- -LSB- -LRB- 125 -RRB- I -RSB- azidoAG-A -RRB- , a photoaffinity analog of the MDR-reversing agent , agosterol_A -LRB- AG-A -RRB- , to photolabel MRP1 , and found that the analog photolabeled the C-proximal molecule of MRP1 -LRB- C -LRB- 932-1531 -RRB- -RRB- in a manner that was GSH-dependent . 11301332 5 11-azidophenyl_agosterol_A 618,644 MRP1 823,827 11-azidophenyl agosterol A MRP1 MESH:C429345 4363 Chemical Gene -RSB-|xcomp|START_ENTITY -LSB-|acl:relcl|-RSB- synthesized|dobj|-LSB- synthesized|conj|found found|ccomp|photolabeled photolabeled|dobj|molecule molecule|nmod|END_ENTITY We synthesized -LSB- -LRB- 125 -RRB- I -RSB- 11-azidophenyl_agosterol_A -LRB- -LSB- -LRB- 125 -RRB- I -RSB- azidoAG-A -RRB- , a photoaffinity analog of the MDR-reversing agent , agosterol_A -LRB- AG-A -RRB- , to photolabel MRP1 , and found that the analog photolabeled the C-proximal molecule of MRP1 -LRB- C -LRB- 932-1531 -RRB- -RRB- in a manner that was GSH-dependent . 18255051 1 11-azidoundecyl_glycoside 152,177 GM1 261,264 11-azidoundecyl glycoside GM1 null 210582(Tax:10090) Chemical Gene undec-10-ynyl|conj|START_ENTITY analogues|amod|undec-10-ynyl analogues|amod|corresponding corresponding|dep|GM3 GM3|conj|END_ENTITY Undec-10-enyl , _ undec-10-ynyl and 11-azidoundecyl_glycoside analogues corresponding to the oligosaccharides of human gangliosides GM3 , GM2 and GM1 were synthesized in high yields using glycosyltransferases from Campylobacter_jejuni . 8898974 3 11B 683,686 glutathione_S-transferase 873,898 11B glutathione S-transferase CHEBI:52451 373156 Chemical Gene UM-SCC|conj|START_ENTITY lines|dep|UM-SCC determined|nmod|lines determined|nsubjpass|5-fluorouracil 5-fluorouracil|conj|content content|nmod|END_ENTITY In ten established head_and_neck_cancer cell lines -LRB- UM-SCC 10A , 10B , 11B , 14A , 14B , 14C , and 22B , HLac79 , 8029NA , and 8029DDP4 -RRB- chemosensitivity to cisplatin , carboplatin , 5-fluorouracil , and bleomycin , as well as cellular glutathione content and activity of glutathione_S-transferase were determined . 15770608 6 11B 1022,1025 spin_3 1010,1016 11B spin 3 CHEBI:52451 169981 Chemical Gene END_ENTITY|conj|START_ENTITY Both 10B -LRB- spin_3 -RRB- and 11B -LRB- spin_3 / 2 -RRB- are quadrupolar nuclei , and their typical relaxation times , in common BNCT agents in biological environments , are rather short . 11703821 6 11B1 858,862 CD151 914,919 11B1 CD151 null 977 Chemical Gene reliable|nsubj|START_ENTITY reliable|nmod|detection detection|nmod|END_ENTITY Of six monoclonal antibodies from four laboratories , 11B1 was found to be the most reliable for detection of CD151 in different cell and tissue contexts . 25204776 8 11B11 1259,1264 CD11b 1327,1332 11B11 CD11b null 3684 Chemical Gene therapy|nmod|START_ENTITY therapy|conj|trastuzumab trastuzumab|acl|resulted resulted|nmod|reduction reduction|nmod|CD206 CD206|compound|END_ENTITY Combination therapy with 11B11 and trastuzumab resulted in a reduction of tumor-infiltrating CD11b -LRB- + -RRB- CD206 -LRB- + -RRB- myeloid cells compared with monotherapy . 9168846 3 11B11 512,517 ovalbumin 548,557 11B11 ovalbumin null 282665(Tax:10090) Chemical Gene treated|nmod|START_ENTITY treated|conj|sensitized sensitized|nmod|saline saline|conj|END_ENTITY Mice treated with 11B11 and sensitized with saline or ovalbumin had significantly less serum IgE than their respective control groups which were treated with saline -LRB- p < 0.05 -RRB- . 21321719 7 11B-11B 2011,2018 B-O-B 2055,2060 11B-11B B-O-B null 2838 Chemical Gene J|appos|START_ENTITY couplings|nsubj|J couplings|advcl|increasing increasing|dobj|angle angle|amod|END_ENTITY First-principles calculations , using the GIPAW approach , of the -LRB- 2 -RRB- J -LRB- 11B-11B -RRB- couplings in lithium_diborate , metaborate and triborate are presented : a clear trend is revealed whereby the -LRB- 2 -RRB- J -LRB- 11B-11B -RRB- couplings increase with increasing B-O-B bond angle and B-B distance . 26658226 7 11b,18-diOH-OT 1419,1433 CYP11B 1366,1372 11b,18-diOH-OT CYP11B null 1584 Chemical Gene resonance|amod|START_ENTITY resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|nummod|END_ENTITY They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT . 26658226 7 11b,18-diOH-OT 1419,1433 CYP11B2 1391,1398 11b,18-diOH-OT CYP11B2 null 1585 Chemical Gene resonance|amod|START_ENTITY resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|acl:relcl|formed formed|nsubj|END_ENTITY They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT . 26658226 7 11b,18-expoxy-18-OH-OT 1495,1517 CYP11B 1366,1372 11b,18-expoxy-18-OH-OT CYP11B null 1584 Chemical Gene rearranges|nmod|START_ENTITY resonance|acl:relcl|rearranges resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|nummod|END_ENTITY They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT . 26658226 7 11b,18-expoxy-18-OH-OT 1495,1517 CYP11B2 1391,1398 11b,18-expoxy-18-OH-OT CYP11B2 null 1585 Chemical Gene rearranges|nmod|START_ENTITY resonance|acl:relcl|rearranges resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|acl:relcl|formed formed|nsubj|END_ENTITY They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT . 9345900 0 11B2-B5 100,107 Acadvl 67,73 11B2-B5 Acadvl null 11370(Tax:10090) Chemical Gene band|nummod|START_ENTITY mouse|dobj|band mouse|nsubj|END_ENTITY Assignment of the gene for very-long-chain acyl-CoA dehydrogenase -LRB- Acadvl -RRB- to mouse chromosome band 11B2-B5 by in situ hybridization . 18392045 5 11B5-C 719,725 TM2 741,744 11B5-C TM2 null 22003(Tax:10090) Chemical Gene regions|conj|START_ENTITY regions|acl:relcl|mapped mapped|nsubjpass|mutations mutations|compound|TM1 TM1|conj|END_ENTITY We could not identify any known gene that was implicated in a similar function in the chromosomal regions 7E-F1 and 11B5-C , where TM1 and TM2 mutations were mapped to respectively . 9194197 3 11B_amino_acids 545,560 myotrophin 530,540 11B amino acids myotrophin null 136319 Chemical Gene has|dobj|START_ENTITY has|nsubj|END_ENTITY Recent cDNA cloning revealed that myotrophin has 11B_amino_acids containing 2.5 contiguous ANK repeats , a motif known to be involved in a wide range of macromolecular recognition . 24074876 0 11b-aminoprogesterone 35,56 mineralocorticoid_receptor 135,161 11b-aminoprogesterone mineralocorticoid receptor null 4306 Chemical Gene derivatives|amod|START_ENTITY encumbered|dobj|derivatives encumbered|nmod|inhibitors inhibitors|conj|antagonists antagonists|compound|END_ENTITY Synthesis of sterically encumbered 11b-aminoprogesterone derivatives and evaluation as 11b-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid_receptor antagonists . 28514642 4 11b-deoxycortisol 915,932 CYP11B1 740,747 11b-deoxycortisol CYP11B1 null 1584 Chemical Gene conversion|nmod|START_ENTITY %|nmod|conversion reduced|nmod|% revealed|ccomp|reduced demonstrated|conj|revealed demonstrated|ccomp|expressed expressed|nsubjpass|type type|nmod|END_ENTITY In vitro expression studies , immunofluorescence demonstrated that wild type and mutant -LRB- L410R and G411C -RRB- proteins of CYP11B1 were correctly expressed on the mitochondria , and enzyme activity assay revealed the mutant reduced the 11-hydroxylase activity to 10 % -LRB- P < 0.001 -RRB- for the conversion of 11b-deoxycortisol to cortisol . 21926601 5 11b-deoxycortisol 818,835 H12 884,887 11b-deoxycortisol H12 null 3006 Chemical Gene concentrations|amod|START_ENTITY cortisol|conj|concentrations assayed|nsubjpass|cortisol assayed|nmod|H6 H6|conj|END_ENTITY MEASUREMENTS AND MAIN RESULTS : After completion of a corticotrophin stimulation test , serum cortisol and 11b-deoxycortisol concentrations were subsequently assayed at H6 , H12 , H24 , and H48 . 15456242 0 11beta-alkyl-Delta9-19-nortestosterone 0,38 androgen_receptor 109,126 11beta-alkyl-Delta9-19-nortestosterone androgen receptor null 367 Chemical Gene derivatives|amod|START_ENTITY derivatives|dep|ligands ligands|conj|agonists agonists|nmod|END_ENTITY 11beta-alkyl-Delta9-19-nortestosterone derivatives : high-affinity ligands and potent partial agonists of the androgen_receptor . 16806946 0 11beta-aryl-substituted_steroids 61,93 progesterone_receptor 4,25 11beta-aryl-substituted steroids progesterone receptor null 5241 Chemical Gene antagonists|dep|START_ENTITY antagonists|compound|END_ENTITY New progesterone_receptor antagonists : phosphorus-containing 11beta-aryl-substituted_steroids . 15857972 4 11beta-benzaldoxime-substituted_estratrienes 578,622 progesterone_receptor 694,715 11beta-benzaldoxime-substituted estratrienes progesterone receptor null 5241 Chemical Gene effects|nummod|START_ENTITY effects|nmod|specificity specificity|compound|END_ENTITY Asoprisnil belongs to the class of 11beta-benzaldoxime-substituted_estratrienes that exhibit partial progesterone agonist/antagonist effects with high progesterone_receptor specificity in animals and humans . 15714390 3 11beta-benzaldoxime-substituted_steroidal 824,865 PR 893,895 11beta-benzaldoxime-substituted steroidal PR null 100724945 Chemical Gene compounds|amod|START_ENTITY compounds|acl|exhibiting exhibiting|dobj|effects effects|compound|END_ENTITY A series of 11beta-benzaldoxime-substituted_steroidal compounds exhibiting mixed PR agonist/antagonist effects were synthesized and characterized . 18427562 5 11beta-dehydrocorticosterone 1025,1053 not_3_h 1099,1106 11beta-dehydrocorticosterone not 3 h null 4849 Chemical Gene 1alpha|conj|START_ENTITY each|amod|1alpha stimulated|nsubj|each stimulated|nmod|h h|dep|END_ENTITY 1alpha , 25-Dihydroxyvitamin_D and 11beta-dehydrocorticosterone each stimulated nVDR expression at 48 h , but not_3_h , by approximately 650 % in fully differentiated adipocytes , whereas the combination augmented this effect -LRB- P < 0.005 -RRB- . 16039525 2 11beta-dichloro 439,454 androgen_receptor 493,510 11beta-dichloro androgen receptor null 367 Chemical Gene molecule|dep|START_ENTITY molecule|acl:relcl|forms forms|ccomp|adducts adducts|xcomp|END_ENTITY A DNA alkylator -LRB- N,N-bis-2-chloroethyl _ aniline -RRB- was linked to a steroid ligand -LRB- 17beta-hyroxy-estra-Delta -LRB- 4 -LRB- 5 -RRB- ,9 -LRB- 10 -RRB- -RRB- -3 - one -RRB- to produce a complex molecule -LRB- 11beta-dichloro -RRB- that forms DNA adducts that bind the androgen_receptor -LRB- AR -RRB- . 16648569 1 11beta-dichloro 113,128 androgen_receptor 158,175 11beta-dichloro androgen receptor null 11835(Tax:10090) Chemical Gene consists|nsubj|START_ENTITY consists|nmod|ligand ligand|nmod|END_ENTITY The multifunctional molecule 11beta-dichloro consists of a ligand for the androgen_receptor linked to a bifunctional alkylating group , permitting it to create DNA adducts that bind the androgen_receptor . 16648569 1 11beta-dichloro 113,128 androgen_receptor 269,286 11beta-dichloro androgen receptor null 11835(Tax:10090) Chemical Gene consists|nsubj|START_ENTITY consists|nmod|ligand ligand|nmod|androgen_receptor androgen_receptor|acl|linked linked|xcomp|permitting permitting|xcomp|create create|dobj|adducts adducts|acl:relcl|bind bind|dobj|END_ENTITY The multifunctional molecule 11beta-dichloro consists of a ligand for the androgen_receptor linked to a bifunctional alkylating group , permitting it to create DNA adducts that bind the androgen_receptor . 16648569 8 11beta-dichloro 1374,1389 androgen_receptor 1513,1530 11beta-dichloro androgen receptor null 11835(Tax:10090) Chemical Gene has|nsubj|START_ENTITY has|dobj|stability stability|acl|enter enter|conj|form form|dobj|adducts adducts|acl:relcl|capable capable|advcl|binding binding|dobj|END_ENTITY Our results indicate that 11beta-dichloro has sufficient stability to enter the circulation , penetrate tissues , and form DNA adducts that are capable of binding the androgen_receptor in target tissues in vivo . 16039525 2 11beta-dichloro 439,454 AR 512,514 11beta-dichloro AR null 367 Chemical Gene molecule|dep|START_ENTITY molecule|acl:relcl|forms forms|ccomp|adducts adducts|xcomp|androgen_receptor androgen_receptor|appos|END_ENTITY A DNA alkylator -LRB- N,N-bis-2-chloroethyl _ aniline -RRB- was linked to a steroid ligand -LRB- 17beta-hyroxy-estra-Delta -LRB- 4 -LRB- 5 -RRB- ,9 -LRB- 10 -RRB- -RRB- -3 - one -RRB- to produce a complex molecule -LRB- 11beta-dichloro -RRB- that forms DNA adducts that bind the androgen_receptor -LRB- AR -RRB- . 7877147 1 11_beta-F-DHT 269,282 androgen_receptor 467,484 11 beta-F-DHT androgen receptor MESH:C092353 24208(Tax:10116) Chemical Gene beta-fluoro-5_alpha-dihydrotestosterone|dep|START_ENTITY prepared|xcomp|beta-fluoro-5_alpha-dihydrotestosterone prepared|advcl|investigate investigate|dobj|properties properties|nmod|androgens androgens|acl|labeled labeled|nmod|END_ENTITY We have prepared 11 beta-fluoro-5_alpha-dihydrotestosterone -LRB- 11_beta-F-DHT , 1 -RRB- and 11 beta-fluoro-19-nor-5_alpha-dihydrotestosterone -LRB- 11_beta-F-19-nor-DHT , 2 -RRB- in order to investigate the properties of these new androgens labeled with fluorine-18 as potential androgen_receptor -LRB- AR -RRB- - based imaging agents for prostate_cancer . 7877147 1 11_beta-F-DHT 269,282 AR 486,488 11 beta-F-DHT AR MESH:C092353 24208(Tax:10116) Chemical Gene beta-fluoro-5_alpha-dihydrotestosterone|dep|START_ENTITY prepared|xcomp|beta-fluoro-5_alpha-dihydrotestosterone prepared|advcl|investigate investigate|dobj|properties properties|nmod|androgens androgens|acl|labeled labeled|nmod|androgen_receptor androgen_receptor|appos|END_ENTITY We have prepared 11 beta-fluoro-5_alpha-dihydrotestosterone -LRB- 11_beta-F-DHT , 1 -RRB- and 11 beta-fluoro-19-nor-5_alpha-dihydrotestosterone -LRB- 11_beta-F-19-nor-DHT , 2 -RRB- in order to investigate the properties of these new androgens labeled with fluorine-18 as potential androgen_receptor -LRB- AR -RRB- - based imaging agents for prostate_cancer . 7877147 3 11_beta-F-DHT 702,715 AR 744,746 11 beta-F-DHT AR MESH:C092353 24208(Tax:10116) Chemical Gene affinities|acl|START_ENTITY affinities|nmod|END_ENTITY Relative binding affinities -LRB- RBA -RRB- of 11_beta-F-DHT and 11_beta-F-19-nor-DHT to AR are 53.1 and 75.3 -LRB- R1881 = 100 -RRB- , respectively , the latter being the highest reported among fluorine-substituted androgens . 18367016 3 11beta-hydoxysteroid 643,663 11beta-HSD1 686,697 11beta-hydoxysteroid 11beta-HSD1 null 15483(Tax:10090) Chemical Gene END_ENTITY|amod|START_ENTITY Recent studies report that these features also occur in subclinical Cushing 's _ syndrome , hypercortisolemic_depression , and the transgenic overexpression of 11beta-hydoxysteroid dehydrogenase type 1 -LRB- 11beta-HSD1 -RRB- in mouse models of excess GC in adipose tissue . 16261451 9 11-beta-hydrosteroid 1259,1279 PTH 1214,1217 11-beta-hydrosteroid PTH null 19226(Tax:10090) Chemical Gene mRNA|amod|START_ENTITY level|nmod|mRNA affect|dobj|level affect|nsubj|END_ENTITY On the other hand , PTH and estrogen did not affect the level of 11-beta-hydrosteroid dehydrogenase type I mRNA increased by Dex . 2511373 5 11-beta-hydroxyandrostenedione 1122,1152 beta-endorphin 1101,1115 11-beta-hydroxyandrostenedione beta-endorphin MESH:C003582 5443 Chemical Gene ACTH|appos|START_ENTITY ACTH|appos|END_ENTITY Other hormones are usually elevated , but not always -LRB- ACTH , aldosterone , prolactin , glucagon , immunoreactive insulin , beta-endorphin , rT3 , 11-beta-hydroxyandrostenedione -RRB- , but there are hormones that are unually low -LRB- T4 , FSH , androstenedione , progesterone -- the latter especially in females -RRB- . 24948873 3 11beta-hydroxyandrostenedione 802,831 AR 901,903 11beta-hydroxyandrostenedione AR MESH:C003582 367 Chemical Gene 11-deoxcorticosterone|conj|START_ENTITY steroids|nmod|11-deoxcorticosterone play|nsubj|steroids play|advcl|promoting promoting|dobj|activation activation|compound|END_ENTITY However , less well-characterized adrenal steroids , including 11-deoxcorticosterone -LRB- DOC -RRB- and 11beta-hydroxyandrostenedione -LRB- 11OH-AED -RRB- may also play a previously unrecognized role in promoting AR activation . 16216911 13 11beta-hydroxyandrostenedione 1710,1739 C-17 1743,1747 11beta-hydroxyandrostenedione C-17 MESH:C003582 54360 Chemical Gene START_ENTITY|nmod|END_ENTITY Furthermore , we found that both enzymes can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms . 5535601 0 11-beta-hydroxycorticosteroids 78,108 insulin 40,47 11-beta-hydroxycorticosteroids insulin null 3630 Chemical Gene fatty_acids|amod|START_ENTITY unconjugated|dobj|fatty_acids unconjugated|nsubj|determination determination|nmod|hormone hormone|dep|END_ENTITY -LSB- Simultaneous determination of glucose , insulin , growth hormone , unconjugated 11-beta-hydroxycorticosteroids , free fatty_acids and amino-nitrogen in the serum of the mother and her newborn child -RSB- . 11696370 1 11beta-hydroxycorticosteroids 293,322 TNF-alpha 189,198 11beta-hydroxycorticosteroids TNF-alpha MESH:D015062 397086(Tax:9823) Chemical Gene access|nmod|START_ENTITY regulating|dobj|access enzyme|acl|regulating 11beta-HSD2|appos|enzyme effect|nmod|11beta-HSD2 effect|appos|END_ENTITY For understanding the mechanism -LRB- s -RRB- relating inflammation to corticosteroid action , the effect of tumour_necrosis factor-alpha -LRB- TNF-alpha -RRB- on 11beta-hydroxysteroid dehydrogenase type 2 -LRB- 11beta-HSD2 -RRB- , the enzyme regulating access of 11beta-hydroxycorticosteroids to receptors , was studied in LLC-PK -LRB- 1 -RRB- cells . 17584152 4 11beta-hydroxyglucocorticoids 754,783 11beta-HSD1 830,841 11beta-hydroxyglucocorticoids 11beta-HSD1 null 3290;26871 Chemical Gene conversion|nmod|START_ENTITY catalyzed|nsubjpass|conversion catalyzed|nmod|END_ENTITY The conversion of inactive 11-ketoglucocorticoids -LRB- cortisone and 11-dehydrocorticosterone -RRB- into active 11beta-hydroxyglucocorticoids -LRB- cortisol and corticosterone -RRB- is catalyzed by 11beta-HSD1 , which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver , adipose tissue and skeletal muscles . 20100662 1 11beta-hydroxyglucocorticoids 305,334 11beta-HSD1 215,226 11beta-hydroxyglucocorticoids 11beta-HSD1 null 3290;26871 Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion inhibition|acl:relcl|catalyzes inhibition|nmod|11beta-hydroxysteroid_dehydrogenase_1 11beta-hydroxysteroid_dehydrogenase_1|dep|END_ENTITY The inhibition of 11beta-hydroxysteroid_dehydrogenase_1 -LRB- 11beta-HSD1 -RRB- , which catalyzes the conversion of inactive 11-ketoglucocorticoids to active 11beta-hydroxyglucocorticoids , emerged as promising strategy to treat symptoms of the metabolic_syndrome , including obesity and type 2 diabetes . 20100662 1 11beta-hydroxyglucocorticoids 305,334 11beta-hydroxysteroid_dehydrogenase_1 176,213 11beta-hydroxyglucocorticoids 11beta-hydroxysteroid dehydrogenase 1 null 3290 Chemical Gene conversion|nmod|START_ENTITY catalyzes|dobj|conversion inhibition|acl:relcl|catalyzes inhibition|nmod|END_ENTITY The inhibition of 11beta-hydroxysteroid_dehydrogenase_1 -LRB- 11beta-HSD1 -RRB- , which catalyzes the conversion of inactive 11-ketoglucocorticoids to active 11beta-hydroxyglucocorticoids , emerged as promising strategy to treat symptoms of the metabolic_syndrome , including obesity and type 2 diabetes . 24303173 3 11beta-hydroxy-glucocorticosteroid 383,417 mineralocorticoid_receptor 330,356 11beta-hydroxy-glucocorticosteroid mineralocorticoid receptor null 25672(Tax:10116) Chemical Gene occurred|nmod|START_ENTITY occurred|nsubj|activation activation|compound|END_ENTITY Here , we hypothesize that mineralocorticoid_receptor activation occurred by an 11beta-hydroxy-glucocorticosteroid , as a consequence of dysregulated_11beta-hydroxysteroid dehydrogenase enzymes . 10375032 3 11beta-hydroxyprogesterone 464,490 glucocorticoid_receptor 514,537 11beta-hydroxyprogesterone glucocorticoid receptor CHEBI:28247 24413(Tax:10116) Chemical Gene binds|nsubj|START_ENTITY binds|nmod|END_ENTITY 11beta-hydroxyprogesterone binds well to both the glucocorticoid_receptor and the carrier protein transcortin . 10375032 3 11beta-hydroxyprogesterone 464,490 transcortin 562,573 11beta-hydroxyprogesterone transcortin CHEBI:28247 299270(Tax:10116) Chemical Gene binds|nsubj|START_ENTITY binds|nmod|glucocorticoid_receptor glucocorticoid_receptor|conj|END_ENTITY 11beta-hydroxyprogesterone binds well to both the glucocorticoid_receptor and the carrier protein transcortin . 9135568 2 11_beta-hydroxysteroid 391,413 11_beta_HSD1 429,441 11 beta-hydroxysteroid 11 beta HSD1 CHEBI:35346 25116(Tax:10116) Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY It has also been proposed that metabolism of dexamethasone might differentiate between the activities of the two isozymes of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD1 and 11_beta_HSD2 -RRB- . 11150889 13 11_beta-hydroxysteroid 1636,1658 11_beta-HSD1 1674,1686 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 3290 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY This constellation clearly indicates cortisone_reductase_deficiency , a defect of hepatic 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta-HSD1 -RRB- . 11481269 2 11_beta-hydroxysteroid 392,414 11_beta-HSD1 471,483 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 3290 Chemical Gene isozymes|amod|START_ENTITY isozymes|dep|oxo-reductase oxo-reductase|dep|END_ENTITY In peripheral tissues , corticosteroid hormone action is regulated at a prereceptor level through the activity of the 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- isozymes : an oxo-reductase -LRB- 11_beta-HSD1 -RRB- that activates cortisol -LRB- F -RRB- from cortisone -LRB- E -RRB- and a dehydrogenase -LRB- 11 beta-HSD2 -RRB- that inactivates F to E . 16234247 0 11_beta-hydroxysteroid 18,40 11_beta-HSD1 56,68 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 25116(Tax:10116) Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY Evidence that the 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta-HSD1 -RRB- is regulated by pentose pathway flux . 16234247 2 11_beta-hydroxysteroid 150,172 11_beta-HSD1 195,207 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 25116(Tax:10116) Chemical Gene type|amod|START_ENTITY type|dep|END_ENTITY 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11_beta-HSD1 -RRB- catalyzes the interconversion of biologically inactive 11 keto derivatives -LRB- cortisone , 11-dehydrocorticosterone -RRB- to active glucocorticoids -LRB- cortisol , corticosterone -RRB- in fat , liver , and other tissues . 19223399 1 11_beta-hydroxysteroid 168,190 11_beta-HSD1 213,225 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 15483(Tax:10090) Chemical Gene type|amod|START_ENTITY type|dep|END_ENTITY In obese humans , metabolism of glucocorticoids by 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11_beta-HSD1 -RRB- and A-ring reduction -LRB- by 5 alpha - and 5 beta-reductases -RRB- is dysregulated in a tissue specific manner . 7495705 1 11_beta-hydroxysteroid 131,153 11_beta-HSD1 171,183 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 3290 Chemical Gene mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY A novel variant of 11_beta-hydroxysteroid dehydrogenase 1 -LRB- 11_beta-HSD1 -RRB- mRNA was identified from the ovine liver by reverse transcription-polymerase chain reaction -LRB- RT/PCR -RRB- , and was named 11_beta-HSD1C mRNA . 8547171 1 11_beta-hydroxysteroid 86,108 11_beta-HSD1 208,220 11 beta-hydroxysteroid 11 beta-HSD1 CHEBI:35346 3290 Chemical Gene dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase catalyse|nsubj|isoforms catalyse|parataxis|affinity affinity|nsubj|END_ENTITY Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of active cortisol to inactive cortisone ; 11_beta-HSD1 is a low affinity , NADP -LRB- H -RRB- - dependent dehydrogenase/oxo-reductase , and 11_beta-HSD2 a high affinity , NAD-dependent dehydrogenase . 17371460 1 11_beta-hydroxysteroid 266,288 11beta-HSD1 306,317 11 beta-hydroxysteroid 11beta-HSD1 CHEBI:35346 3290;26871 Chemical Gene dehydrogenase|amod|START_ENTITY effect|nmod|dehydrogenase modulating|nmod|effect plays|advcl|modulating plays|nsubj|1 1|dep|END_ENTITY The growth_hormone-insulin-like growth factor 1 -LRB- GH-IGF-1 -RRB- axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11_beta-hydroxysteroid dehydrogenase 1 -LRB- 11beta-HSD1 -RRB- which , in vivo , functions as a reductase catalysing the conversion of cortisone to cortisol . 17640483 1 11_beta-hydroxysteroid 138,160 11beta-HSD1 183,194 11 beta-hydroxysteroid 11beta-HSD1 CHEBI:35346 15483(Tax:10090) Chemical Gene END_ENTITY|amod|START_ENTITY AIM : To investigate the relationship between 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11beta-HSD1 -RRB- , a potential link between obesity and type 2 diabetes , and preadipocyte differentiation . 7593417 1 11_beta-hydroxysteroid 245,267 11_beta_HSD2 283,295 11 beta-hydroxysteroid 11 beta HSD2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY Four deleterious mutations are described in the gene for HSD11B2 , which encodes the type 2 isoenzyme of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD2 -RRB- . 9135568 2 11_beta-hydroxysteroid 391,413 11_beta_HSD2 446,458 11 beta-hydroxysteroid 11 beta HSD2 CHEBI:35346 25117(Tax:10116) Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|11_beta_HSD1 11_beta_HSD1|conj|END_ENTITY It has also been proposed that metabolism of dexamethasone might differentiate between the activities of the two isozymes of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD1 and 11_beta_HSD2 -RRB- . 14629298 1 11_beta-hydroxysteroid 187,209 11_beta-HSD2 232,244 11 beta-hydroxysteroid 11 beta-HSD2 CHEBI:35346 3291 Chemical Gene END_ENTITY|amod|START_ENTITY We examined the immunohistochemical distribution of 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11_beta-HSD2 -RRB- , the enzyme responsible for the conversion of bioactive glucocorticoids to their receptor-inactive forms , in lung tissue obtained at autopsy from 14 patients who had died due to acute_respiratory_distress_syndrome -LRB- ARDS -RRB- . 7556871 1 11_beta-hydroxysteroid 137,159 11_beta-HSD2 177,189 11 beta-hydroxysteroid 11 beta-HSD2 CHEBI:35346 443530(Tax:9940) Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY The cellular localization of 11_beta-hydroxysteroid dehydrogenase 2 -LRB- 11_beta-HSD2 -RRB- gene expression in the ovine adrenal gland was determined by in situ hybridization histochemistry . 8547171 1 11_beta-hydroxysteroid 86,108 11_beta-HSD2 291,303 11 beta-hydroxysteroid 11 beta-HSD2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase catalyse|nsubj|isoforms catalyse|parataxis|affinity affinity|amod|dehydrogenase/oxo-reductase dehydrogenase/oxo-reductase|conj|END_ENTITY Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of active cortisol to inactive cortisone ; 11_beta-HSD1 is a low affinity , NADP -LRB- H -RRB- - dependent dehydrogenase/oxo-reductase , and 11_beta-HSD2 a high affinity , NAD-dependent dehydrogenase . 8611186 1 11_beta-hydroxysteroid 128,150 11_beta-HSD2 173,185 11 beta-hydroxysteroid 11 beta-HSD2 CHEBI:35346 3291 Chemical Gene type|amod|START_ENTITY inactivates|nsubj|type inactivates|advmod|efficiently efficiently|nmod:npmod|2 2|dep|END_ENTITY 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11_beta-HSD2 -RRB- efficiently inactivates potent glucocorticoid hormones -LRB- cortisol and corticosterone -RRB- , leaving aldosterone unmetabolized . 8977758 1 11_beta-hydroxysteroid 126,148 11_beta-HSD2 267,279 11 beta-hydroxysteroid 11 beta-HSD2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase OBJECTIVE|dep|isoforms OBJECTIVE|dep|defects defects|nmod|result result|amod|END_ENTITY OBJECTIVE : Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of cortisol to hormonally inactive cortisone ; defects in the 11_beta-HSD2 isoform result in hypertension . 18178212 1 11_beta-hydroxysteroid 139,161 11beta-HSD2 179,190 11 beta-hydroxysteroid 11beta-HSD2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY activity|nmod|dehydrogenase activity|acl:relcl|induces induces|nsubj|2 2|dep|END_ENTITY BACKGROUND : Lower activity of 11_beta-hydroxysteroid dehydrogenase 2 -LRB- 11beta-HSD2 -RRB- classically induces hypertension by leading to an altered tetrahydrocortisol - versus tetrahydrocortisone-metabolites -LRB- THFs/THE -RRB- shuttle . 19075542 1 11_beta-hydroxysteroid 294,316 11beta-HSD2 339,350 11 beta-hydroxysteroid 11beta-HSD2 CHEBI:35346 3291 Chemical Gene type|amod|START_ENTITY due|nmod|type state|amod|due state|dep|END_ENTITY Two elderly patients with mineralocorticoid excess state due to 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11beta-HSD2 -RRB- impairment are described . 9029722 4 11_beta-hydroxysteroid 959,981 15-hydroxyprostaglandin_dehydrogenase 1000,1037 11 beta-hydroxysteroid 15-hydroxyprostaglandin dehydrogenase CHEBI:35346 873 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|conj|END_ENTITY The three-dimensional structure of the 3 alpha ,20 beta-HSD carbenoxolone complex unequivocally verifies the postulated active site of the enzyme , shows that inhibition is a result of direct competition with the substrate for binding , and provides a plausible model for the mechanism of inhibition of 11_beta-hydroxysteroid dehydrogenase and 15-hydroxyprostaglandin_dehydrogenase by carbenoxolone . 7828353 16 11_beta-hydroxysteroid 3598,3620 GH 3543,3545 11 beta-hydroxysteroid GH CHEBI:35346 2688 Chemical Gene dehydrogenase|amod|START_ENTITY activity|nmod|dehydrogenase modulate|dobj|activity modulate|nsubj|END_ENTITY The changes in F/E suggest that GH may directly or indirectly modulate the activity of 11_beta-hydroxysteroid dehydrogenase . 12605557 9 11_beta-hydroxysteroid 1715,1737 glucagon-like_peptide_1 1792,1815 11 beta-hydroxysteroid glucagon-like peptide 1 CHEBI:35346 2641 Chemical Gene inhibitors|amod|START_ENTITY inhibitors|conj|modulators modulators|nmod|axis axis|amod|END_ENTITY These initiatives , together with developments in beta -LRB- 3 -RRB- - adrenoceptor agonists , 11_beta-hydroxysteroid dehydrogenase Type 1 inhibitors and modulators of the glucagon-like_peptide_1 axis , all of which also potentially enhance insulin sensitivity , are critically evaluated . 1734933 0 11_beta-hydroxysteroid 23,45 glucocorticoid_receptor 88,111 11 beta-hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene dehydrogenase|amod|START_ENTITY localization|nmod|dehydrogenase localization|nmod|END_ENTITY Tissue localization of 11_beta-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid_receptor . 8969930 5 11_beta-hydroxysteroid 1164,1186 glucocorticoid_receptor 1080,1103 11 beta-hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene dehydrogenase|amod|START_ENTITY cortisol|nmod|dehydrogenase inactivation|nmod|cortisol explained|nmod|inactivation explained|nmod|affinity affinity|compound|END_ENTITY Our data suggest that the increase in dermal glucocorticoid sensitivity is not a secondary phenomenon and may be explained by increased glucocorticoid_receptor affinity together with impaired inactivation of cortisol by 11_beta-hydroxysteroid dehydrogenase . 21802269 6 11_beta-hydroxysteroid 852,874 Glucocorticoid_receptor 822,845 11 beta-hydroxysteroid Glucocorticoid receptor CHEBI:35346 14815(Tax:10090) Chemical Gene type|amod|START_ENTITY END_ENTITY|conj|type Glucocorticoid_receptor -LRB- GR -RRB- , 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11b-HSD1 -RRB- and 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expressions in liver were determined by western blotting . 7649347 0 11_beta-hydroxysteroid 54,76 Glucocorticoid_receptor 0,23 11 beta-hydroxysteroid Glucocorticoid receptor CHEBI:35346 24413(Tax:10116) Chemical Gene expression|amod|START_ENTITY receptors|appos|expression END_ENTITY|appos|receptors Glucocorticoid_receptor , mineralocorticoid receptors , 11_beta-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney : in situ studies . 21802269 6 11_beta-hydroxysteroid 852,874 GR 847,849 11 beta-hydroxysteroid GR CHEBI:35346 14815(Tax:10090) Chemical Gene type|amod|START_ENTITY Glucocorticoid_receptor|conj|type Glucocorticoid_receptor|appos|END_ENTITY Glucocorticoid_receptor -LRB- GR -RRB- , 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11b-HSD1 -RRB- and 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expressions in liver were determined by western blotting . 8370690 0 11_beta-hydroxysteroid 35,57 HSD11 15,20 11 beta-hydroxysteroid HSD11 CHEBI:35346 3290 Chemical Gene dehydrogenase|amod|START_ENTITY encoding|dobj|dehydrogenase gene|acl|encoding gene|compound|END_ENTITY Defects in the HSD11 gene encoding 11_beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid_excess_or_11-oxoreductase_deficiency . 7593417 1 11_beta-hydroxysteroid 245,267 HSD11B2 198,205 11 beta-hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY isoenzyme|nmod|dehydrogenase encodes|dobj|isoenzyme gene|acl:relcl|encodes gene|nmod|END_ENTITY Four deleterious mutations are described in the gene for HSD11B2 , which encodes the type 2 isoenzyme of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD2 -RRB- . 12605557 9 11_beta-hydroxysteroid 1715,1737 insulin 1860,1867 11 beta-hydroxysteroid insulin CHEBI:35346 3630 Chemical Gene inhibitors|amod|START_ENTITY inhibitors|acl:relcl|enhance enhance|dobj|sensitivity sensitivity|compound|END_ENTITY These initiatives , together with developments in beta -LRB- 3 -RRB- - adrenoceptor agonists , 11_beta-hydroxysteroid dehydrogenase Type 1 inhibitors and modulators of the glucagon-like_peptide_1 axis , all of which also potentially enhance insulin sensitivity , are critically evaluated . 7792800 1 11_beta-hydroxysteroid 60,82 mineralocorticoid_receptor 292,318 11 beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY pre-receptor|nsubj|dehydrogenase pre-receptor|acl|signaling signaling|nmod|END_ENTITY 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- , by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone , respectively , is an important pre-receptor signaling pathway for the renal mineralocorticoid_receptor -LRB- MR -RRB- . 8070376 0 11_beta-hydroxysteroid 99,121 mineralocorticoid_receptor 4,30 11 beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY glucocorticoids|nmod|dehydrogenase discriminates|nmod|glucocorticoids discriminates|nsubj|END_ENTITY The mineralocorticoid_receptor discriminates aldosterone from glucocorticoids independently of the 11_beta-hydroxysteroid dehydrogenase . 8070376 1 11_beta-hydroxysteroid 325,347 mineralocorticoid_receptor 222,248 11 beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY receptor|conj|dehydrogenase contribution|nmod|receptor studied|dobj|contribution studied|advcl|investigate investigate|dobj|mechanisms mechanisms|acl|involved involved|nmod|selectivity selectivity|nmod|END_ENTITY To investigate the mechanisms involved in the in vivo aldosterone selectivity of the mineralocorticoid_receptor -LRB- MR -RRB- , we studied the respective contribution of the receptor and the enzyme 11_beta-hydroxysteroid dehydrogenase -LRB- 11HSD -RRB- , which converts glucocorticoids into inactive metabolites . 8191539 3 11_beta-hydroxysteroid 530,552 mineralocorticoid_receptor 612,638 11 beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY action|nmod|dehydrogenase position|nmod|action glucocorticoids|nmod|position Inactivation|nmod|glucocorticoids permits|nsubj|Inactivation permits|dobj|occupation occupation|nmod|END_ENTITY Inactivation of glucocorticoids at the 11-hydroxyl position by the action of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-OHSD -RRB- permits the occupation of the mineralocorticoid_receptor by aldosterone in the presence of much higher levels of circulating cortisol . 8191539 6 11_beta-hydroxysteroid 1069,1091 mineralocorticoid_receptor 1246,1272 11 beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY attributes|nmod|dehydrogenase isozymes|nsubj|attributes isozymes|dobj|reasons reasons|acl:relcl|appears appears|xcomp|candidate candidate|acl|endow endow|nmod|END_ENTITY This review examines the attributes of these 11_beta-hydroxysteroid dehydrogenase isozymes and suggests reasons why a high affinity , NAD-dependent enzyme appears to be the most likely candidate to endow specificity on the mineralocorticoid_receptor . 7600648 4 11_beta-hydroxysteroid 564,586 MR 418,420 11 beta-hydroxysteroid MR CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY presence|nmod|dehydrogenase requires|dobj|presence requires|advcl|displays displays|nsubj|END_ENTITY Because MR displays similar affinities for aldosterone and glucocorticoids , the in vivo aldosterone selectivity of MR requires the presence of an enzyme , 11_beta-hydroxysteroid dehydrogenase -LRB- 11-HSD -RRB- , which metabolizes glucocorticoids into inactive derivatives . 7600648 4 11_beta-hydroxysteroid 564,586 MR 525,527 11 beta-hydroxysteroid MR CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY presence|nmod|dehydrogenase requires|dobj|presence requires|nsubj|selectivity selectivity|nmod|END_ENTITY Because MR displays similar affinities for aldosterone and glucocorticoids , the in vivo aldosterone selectivity of MR requires the presence of an enzyme , 11_beta-hydroxysteroid dehydrogenase -LRB- 11-HSD -RRB- , which metabolizes glucocorticoids into inactive derivatives . 7792800 1 11_beta-hydroxysteroid 60,82 MR 320,322 11 beta-hydroxysteroid MR CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY pre-receptor|nsubj|dehydrogenase pre-receptor|acl|signaling signaling|nmod|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- , by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone , respectively , is an important pre-receptor signaling pathway for the renal mineralocorticoid_receptor -LRB- MR -RRB- . 8070376 1 11_beta-hydroxysteroid 325,347 MR 250,252 11 beta-hydroxysteroid MR CHEBI:35346 4306 Chemical Gene dehydrogenase|amod|START_ENTITY receptor|conj|dehydrogenase contribution|nmod|receptor studied|dobj|contribution studied|advcl|investigate investigate|dobj|mechanisms mechanisms|acl|involved involved|nmod|selectivity selectivity|nmod|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY To investigate the mechanisms involved in the in vivo aldosterone selectivity of the mineralocorticoid_receptor -LRB- MR -RRB- , we studied the respective contribution of the receptor and the enzyme 11_beta-hydroxysteroid dehydrogenase -LRB- 11HSD -RRB- , which converts glucocorticoids into inactive metabolites . 1338959 1 11_beta-hydroxysteroid 137,159 POMC 101,105 11 beta-hydroxysteroid POMC CHEBI:35346 443212(Tax:9940) Chemical Gene dehydrogenase|amod|START_ENTITY Expression|conj|dehydrogenase Expression|appos|END_ENTITY Expression of genes encoding pro-opiomelanocortin -LRB- POMC -RRB- , glucocorticoid_receptors and 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- was studied in sheep fetuses during development . 1639208 0 11_beta-hydroxysteroid 0,22 SCAD 80,84 11 beta-hydroxysteroid SCAD CHEBI:35346 35 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY 11_beta-hydroxysteroid dehydrogenase and the short-chain_alcohol_dehydrogenase -LRB- SCAD -RRB- superfamily . 1639208 0 11_beta-hydroxysteroid 0,22 short-chain_alcohol_dehydrogenase 45,78 11 beta-hydroxysteroid short-chain alcohol dehydrogenase CHEBI:35346 35 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|conj|END_ENTITY 11_beta-hydroxysteroid dehydrogenase and the short-chain_alcohol_dehydrogenase -LRB- SCAD -RRB- superfamily . 2239425 3 11_beta-hydroxysteroid 480,502 transcortin 452,463 11 beta-hydroxysteroid transcortin CHEBI:35346 866 Chemical Gene dehydrogenase|amod|START_ENTITY END_ENTITY|conj|dehydrogenase Ligand specificity of mineralocorticoid_receptors for either corticosterone or aldosterone seems to be determined by co-localized transcortin and the enzyme , 11_beta-hydroxysteroid dehydrogenase . 20515440 2 11-beta_hydroxysteroid 314,336 11beta-HSD1 376,387 11-beta hydroxysteroid 11beta-HSD1 CHEBI:35346 3290;26871 Chemical Gene dehydrogenase|amod|START_ENTITY 11beta-HSD|appos|dehydrogenase 11beta-HSD|amod|11beta-HSD2 11beta-HSD2|conj|END_ENTITY Cortisol activation of vascular mineralocorticoid and glucocorticoid receptors is regulated by two types of 11beta-HSD -LRB- 11-beta_hydroxysteroid dehydrogenase -RRB- , namely 11beta-HSD2 and 11beta-HSD1 -LRB- type 2 and type 1 11beta-HSD respectively -RRB- . 26365331 9 11-beta_hydroxysteroid 1171,1193 11bHSD-1 1211,1219 11-beta hydroxysteroid 11bHSD-1 CHEBI:35346 25116(Tax:10116) Chemical Gene dehydrogenase-1|amod|START_ENTITY dehydrogenase-1|dep|END_ENTITY Mediators of hepatic glucocorticoid metabolism , specifically 11-beta_hydroxysteroid dehydrogenase-1 -LRB- 11bHSD-1 -RRB- , 5-a reductase , and glucocorticoid and mineralocorticoid receptor mRNAs were also measured . 19646461 0 11-beta_hydroxysteroid 69,91 glucocorticoid_receptor 41,64 11-beta hydroxysteroid glucocorticoid receptor CHEBI:35346 24413(Tax:10116) Chemical Gene END_ENTITY|conj|START_ENTITY Effects of a high-salt diet on adipocyte glucocorticoid_receptor and 11-beta_hydroxysteroid dehydrogenase 1 in salt-sensitive hypertensive rats . 25459891 2 11-beta_hydroxysteroid 551,573 glucocorticoid_receptor 470,493 11-beta hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene dehydrogenase|amod|START_ENTITY genes|conj|dehydrogenase genes|conj|END_ENTITY DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior . 22238371 2 11-beta_hydroxysteroid 285,307 HSD11B1 323,330 11-beta hydroxysteroid HSD11B1 CHEBI:35346 3290 Chemical Gene dehydrogenase|amod|START_ENTITY Variation|nmod|dehydrogenase Variation|appos|END_ENTITY Variation in 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B1 -RRB- is associated with cortisone_reductase_deficiency , a condition with a phenotype similar to PCOS . 22432047 2 11-beta_hydroxysteroid 364,386 HSD11B2 338,345 11-beta hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene enzyme|amod|START_ENTITY regulated|nsubjpass|enzyme encoding|ccomp|regulated encoding|nsubj|gene gene|compound|END_ENTITY In the placenta , the HSD11B2 gene encoding the 11-beta_hydroxysteroid dehydrogenase enzyme , which is responsible for the inactivation of maternal cortisol , is regulated by DNA methylation , and has been shown to be susceptible to stressors from the maternal environment . 24040322 3 11-beta_hydroxysteroid 474,496 HSD11B2 449,456 11-beta hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene enzyme|amod|START_ENTITY encodes|dobj|enzyme encodes|nsubj|gene gene|compound|END_ENTITY In the placenta , the HSD11B2 gene encodes the 11-beta_hydroxysteroid dehydrogenase enzyme , which is responsible for the inactivation of maternal cortisol thereby protecting the developing fetus from this exposure . 25459891 2 11-beta_hydroxysteroid 551,573 HSD11B2 589,596 11-beta hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior . 28502862 3 11-beta_hydroxysteroid 398,420 HSD11B2 453,460 11-beta hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene type|amod|START_ENTITY type|appos|11b-HSD2 11b-HSD2|dep|gene gene|compound|END_ENTITY The placental enzyme 11-beta_hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 , HSD11B2 gene -RRB- acts as a barrier protecting the fetus from maternal corticosteroid deleterious effects . 12711009 2 11-beta_hydroxysteroid 529,551 MR 362,364 11-beta hydroxysteroid MR CHEBI:35346 4306 Chemical Gene 11-dehydroderivatives|advcl|START_ENTITY dehydrogenase|amod|11-dehydroderivatives require|nmod|dehydrogenase require|advcl|prevent prevent|dobj|occupancy occupancy|nmod|END_ENTITY To prevent permanent and maximal occupancy of MR by glucocorticoid hormones in aldosterone-target cells , specific effects of aldosterone require metabolism of glucocorticoid hormones into 11-dehydroderivatives by 11-beta_hydroxysteroid dehydrogenase -LRB- 11-HSD2 -RRB- . 23152847 4 11-beta_hydroxysteroid 626,648 MR 580,582 11-beta hydroxysteroid MR CHEBI:35346 4306 Chemical Gene expression|amod|START_ENTITY END_ENTITY|conj|expression Three hours after onset of EIU , the MR and the glucocorticoid metabolizing enzyme 11-beta_hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expression were down-regulated in iris/ciliary body and the corticosterone concentration was increased in aqueous_humor , altering the normal MR/glucocorticoid receptor -LRB- GR -RRB- balance . 25459891 2 11-beta_hydroxysteroid 551,573 NR3C1 495,500 11-beta hydroxysteroid NR3C1 CHEBI:35346 2908 Chemical Gene dehydrogenase|amod|START_ENTITY genes|conj|dehydrogenase genes|conj|glucocorticoid_receptor glucocorticoid_receptor|appos|END_ENTITY DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior . 21879473 1 11-beta-hydroxysteroid 129,151 11-beta-HSD1 174,186 11-beta-hydroxysteroid 11-beta-HSD1 CHEBI:35346 25116(Tax:10116) Chemical Gene I|amod|START_ENTITY I|dep|END_ENTITY BACKGROUND : 11-beta-hydroxysteroid dehydrogenase type I -LRB- 11-beta-HSD1 -RRB- in the white_adipose_tissue -LRB- WAT -RRB- of rats catalyses the conversion of 11-dehydrocorticosterone to corticosterone , a more active glucocorticosteroid . 16941796 2 11-beta-hydroxysteroid 222,244 11-beta-HSD-1 262,275 11-beta-hydroxysteroid 11-beta-HSD-1 MESH:D006914 3290 Chemical Gene perilipins|conj|START_ENTITY enzyme|amod|perilipins enzyme|dep|END_ENTITY An hypothesis that aberrant expression of perilipins and 11-beta-hydroxysteroid dehydrogenase-1 -LRB- 11-beta-HSD-1 -RRB- enzyme plays a significant role in the development of metabolic_syndrome X in Indians is proposed . 17616511 1 11-beta-hydroxysteroid 237,259 At5g50600 179,188 11-beta-hydroxysteroid At5g50600 CHEBI:35346 835129(Tax:3702) Chemical Gene dehydrogenase|amod|START_ENTITY protein|nmod|dehydrogenase encodes|dobj|protein AtHSD1|acl:relcl|encodes AtHSD1|appos|END_ENTITY We have functionally characterized an Arabidopsis -LRB- Arabidopsis_thaliana -RRB- gene AtHSD1 -LRB- At5g50600 -RRB- that encodes a protein with homology to animal 11-beta-hydroxysteroid dehydrogenase -LRB- HSD -RRB- . 17616511 1 11-beta-hydroxysteroid 237,259 AtHSD1 171,177 11-beta-hydroxysteroid AtHSD1 CHEBI:35346 835141(Tax:3702) Chemical Gene dehydrogenase|amod|START_ENTITY protein|nmod|dehydrogenase encodes|dobj|protein END_ENTITY|acl:relcl|encodes We have functionally characterized an Arabidopsis -LRB- Arabidopsis_thaliana -RRB- gene AtHSD1 -LRB- At5g50600 -RRB- that encodes a protein with homology to animal 11-beta-hydroxysteroid dehydrogenase -LRB- HSD -RRB- . 15246063 7 11-beta-hydroxysteroid 1083,1105 ATS1 1026,1030 11-beta-hydroxysteroid ATS1 CHEBI:35346 840112(Tax:3702) Chemical Gene protein|amod|START_ENTITY protein|conj|protein protein|nmod|protein oleosins|appos|protein oleosins|appos|END_ENTITY This led to the identification of a limited number of proteins : four different oleosins , ATS1 , a protein homologous to calcium binding protein , a 11-beta-hydroxysteroid dehydrogenase-like protein , a probable aquaporin and a glycosylphosphatidylinositol-anchored protein with no known function . 21803757 6 11-beta-hydroxysteroid 872,894 CYP19 864,869 11-beta-hydroxysteroid CYP19 CHEBI:35346 1588 Chemical Gene I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|appos|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 16675933 6 11-beta-hydroxysteroid 1017,1039 CYP3A 1065,1070 11-beta-hydroxysteroid CYP3A CHEBI:35346 1576 Chemical Gene dehydrogenase|amod|START_ENTITY dehydrogenase|amod|type-1 type-1|conj|END_ENTITY To add to the complexity , endocrine and paracrine cortisol levels and actions depend much on the activity of metabolizing enzymes , such as 11-beta-hydroxysteroid dehydrogenase type-1 and CYP3A . 21803757 6 11-beta-hydroxysteroid 872,894 ESR1 1036,1040 11-beta-hydroxysteroid ESR1 CHEBI:35346 2099 Chemical Gene I|amod|START_ENTITY receptor|compound|I receptor|appos|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 21803757 6 11-beta-hydroxysteroid 872,894 ESR2 1045,1049 11-beta-hydroxysteroid ESR2 CHEBI:35346 2100 Chemical Gene I|amod|START_ENTITY receptor|compound|I receptor|appos|ESR1 ESR1|conj|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 21803757 6 11-beta-hydroxysteroid 872,894 GCR 1080,1083 11-beta-hydroxysteroid GCR CHEBI:35346 2908 Chemical Gene I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|conj|-RSB- -RSB-|appos|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 12570714 2 11-beta-hydroxysteroid 295,317 glucagon_receptor 252,269 11-beta-hydroxysteroid glucagon receptor CHEBI:35346 2642 Chemical Gene dehydrogenase-1|amod|START_ENTITY END_ENTITY|conj|dehydrogenase-1 Antagonists of the glucagon_receptor , glycogen phosphorylase , 11-beta-hydroxysteroid dehydrogenase-1 and fructose 1,6-bisphosphatase are , or have been , under evaluation in human clinical trials . 19048413 0 11-beta-hydroxysteroid 32,54 glucocorticoid_receptor 80,103 11-beta-hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene type|amod|START_ENTITY type|conj|END_ENTITY Immunohistochemical analysis of 11-beta-hydroxysteroid dehydrogenase type 2 and glucocorticoid_receptor in subclinical Cushing 's _ disease due to pituitary_macroadenoma . 21803757 6 11-beta-hydroxysteroid 872,894 glucocorticoid_receptor 1055,1078 11-beta-hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|conj|-RSB- -RSB-|amod|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 24443823 7 11-beta-hydroxysteroid 1100,1122 glucocorticoid_receptor 1020,1043 11-beta-hydroxysteroid glucocorticoid receptor CHEBI:35346 2908 Chemical Gene type|amod|START_ENTITY END_ENTITY|conj|type Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 24443823 7 11-beta-hydroxysteroid 1100,1122 GR 1045,1047 11-beta-hydroxysteroid GR CHEBI:35346 2908 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|appos|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 21803757 6 11-beta-hydroxysteroid 872,894 H6PD 963,967 11-beta-hydroxysteroid H6PD CHEBI:35346 9563 Chemical Gene I|amod|START_ENTITY I|conj|-RSB- -RSB-|appos|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 21803757 6 11-beta-hydroxysteroid 872,894 hexose-6-phosphate_dehydogenase 930,961 11-beta-hydroxysteroid hexose-6-phosphate dehydogenase CHEBI:35346 9563 Chemical Gene I|amod|START_ENTITY I|conj|-RSB- -RSB-|amod|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 21803757 6 11-beta-hydroxysteroid 872,894 HSD11B1 917,924 11-beta-hydroxysteroid HSD11B1 CHEBI:35346 3290 Chemical Gene I|amod|START_ENTITY I|appos|END_ENTITY Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- . 24443823 7 11-beta-hydroxysteroid 1100,1122 HSD11B2 1161,1168 11-beta-hydroxysteroid HSD11B2 CHEBI:35346 3291 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type _|nsubj|glucocorticoid_receptor _|ccomp|quantified quantified|nsubjpass|levels levels|appos|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 17565863 0 11-beta-hydroxysteroid 46,68 mineralocorticoid_receptor 15,41 11-beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene END_ENTITY|conj|START_ENTITY -LSB- Expression of mineralocorticoid_receptor and 11-beta-hydroxysteroid dehydrogenase type 2 in human atria during chronic atrial_fibrillation : study of 25 cases -RSB- . 24443823 7 11-beta-hydroxysteroid 1100,1122 mineralocorticoid_receptor 1057,1083 11-beta-hydroxysteroid mineralocorticoid receptor CHEBI:35346 4306 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 24443823 7 11-beta-hydroxysteroid 1100,1122 MR 1085,1087 11-beta-hydroxysteroid MR CHEBI:35346 4306 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 24443823 7 11-beta-hydroxysteroid 1100,1122 NR3C1 1049,1054 11-beta-hydroxysteroid NR3C1 CHEBI:35346 2908 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|appos|GR GR|dep|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 24443823 7 11-beta-hydroxysteroid 1100,1122 NR3C2 1089,1094 11-beta-hydroxysteroid NR3C2 CHEBI:35346 4306 Chemical Gene type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|mineralocorticoid_receptor mineralocorticoid_receptor|appos|MR MR|dep|END_ENTITY Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR . 18287225 5 11beta_hydroxysteroid 724,745 beta3_adrenergic_receptor 824,849 11beta hydroxysteroid beta3 adrenergic receptor MESH:D006914 155 Chemical Gene and_2|amod|START_ENTITY and_2|conj|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 beta3AR 851,858 11beta hydroxysteroid beta3AR MESH:D006914 155 Chemical Gene and_2|amod|START_ENTITY and_2|conj|beta3_adrenergic_receptor beta3_adrenergic_receptor|appos|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 deiodinase_type_1 861,878 11beta hydroxysteroid deiodinase type 1 MESH:D006914 1733 Chemical Gene and_2|amod|START_ENTITY and_2|conj|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 DIO1 880,884 11beta hydroxysteroid DIO1 MESH:D006914 1733 Chemical Gene and_2|amod|START_ENTITY and_2|conj|deiodinase_type_1 deiodinase_type_1|appos|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 DIO2 890,894 11beta hydroxysteroid DIO2 MESH:D006914 1734 Chemical Gene and_2|amod|START_ENTITY and_2|conj|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 glucocorticoid_receptor 794,817 11beta hydroxysteroid glucocorticoid receptor MESH:D006914 2908 Chemical Gene and_2|amod|START_ENTITY and_2|conj|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 GR 819,821 11beta hydroxysteroid GR MESH:D006914 2908 Chemical Gene and_2|amod|START_ENTITY and_2|conj|glucocorticoid_receptor glucocorticoid_receptor|appos|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 HSD11B2 784,791 11beta hydroxysteroid HSD11B2 MESH:D006914 3291 Chemical Gene and_2|amod|START_ENTITY and_2|appos|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 PGC1alpha 991,1000 11beta hydroxysteroid PGC1alpha MESH:D006914 10891 Chemical Gene and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|conj|PPARgamma PPARgamma|dep|coactivator coactivator|appos|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 PPARgamma 966,975 11beta hydroxysteroid PPARgamma MESH:D006914 5468 Chemical Gene and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|conj|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 UCP1 712,716 11beta hydroxysteroid UCP1 MESH:D006914 7350 Chemical Gene and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|nmod|UCP2 UCP2|compound|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- . 18287225 5 11beta_hydroxysteroid 724,745 UCP2 718,722 11beta hydroxysteroid UCP2 MESH:D006914 7351 Chemical Gene and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|nmod|END_ENTITY Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_