26806347	3	-	688,689	AR	543,545	-	AR	null	367	Chemical	Gene	+|conj|START_ENTITY status|dep|+ performed|dobj|status performed|advcl|assess assess|dobj|role role|nmod|END_ENTITY	To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples .
26806347	3	-	688,689	AR	659,661	-	AR	null	367	Chemical	Gene	+|conj|START_ENTITY status|dep|+ status|amod|signaling signaling|nmod|analysis analysis|nmod|samples samples|amod|stratified stratified|nmod|END_ENTITY	To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples .
26806347	3	-	688,689	AR	750,752	-	AR	null	367	Chemical	Gene	+|conj|START_ENTITY status|dep|+ status|acl:relcl|identified identified|nmod|samples samples|amod|increased increased|nmod|END_ENTITY	To assess the role of AR signaling on MET inhibition , we first performed an in silico analysis of human CRPC tissue samples stratified by AR signaling status -LRB- -LRB- + -RRB- or -LRB- - -RRB- -RRB- , which identified MET expression as markedly increased in AR -LRB- - -RRB- samples .
2347471	7	-	1258,1259	CD16	1233,1237	-	CD16	null	2214	Chemical	Gene	Leu7|conj|START_ENTITY END_ENTITY|conj|Leu7	In contrast , the population of activated natural killer cells -LRB- CD16 -LRB- + -RRB- and Leu7 -LRB- + -RRB- or -LRB- - -RRB- -RRB- remained below 4 % for the entire period of culture .
25893674	4	-	892,893	Cd38	806,810	-	Cd38	null	12494(Tax:10090)	Chemical	Gene	START_ENTITY|appos|- APP.PS.Cd38|dobj|- mice|dep|APP.PS.Cd38 mice|nmod|END_ENTITY	METHODS : We crossed APPswePS1 E9 -LRB- APP.PS -RRB- mice with Cd38 -LRB- - -RRB- -LRB- / -RRB- -LRB- - -RRB- mice to generate AD-prone CD38-deficient animals -LRB- APP.PS.Cd38 -LRB- - -RRB- -LRB- / -RRB- -LRB- - -RRB- -RRB- and examined AD-related phenotypes in both groups .
24416664	5	-	570,571	CIM	653,656	-	CIM	null	27248	Chemical	Gene	START_ENTITY|acl:relcl|show show|ccomp|% %|nsubj|expenditures expenditures|nmod|END_ENTITY	-LRB- 1 -RRB- -LRB- - -RRB- -LRB- 4 -RRB- The most recent estimates show that total US out-of-pocket expenditures for CIM were 34 billion-11 % of all US out-of-pocket healthcare expenditures .
27956676	10	-	1581,1582	fibrinogen	1439,1449	-	fibrinogen	null	2244	Chemical	Gene	dL|appos|START_ENTITY h|dep|dL difference|nmod|h admission|nmod|difference remained|nmod|admission remained|nsubj|concentrations concentrations|compound|END_ENTITY	Plasma fibrinogen concentrations remained higher in the FC group up to 12 h after admission with the largest difference at three h -LRB- 2.9 mg dL -LRB- - -RRB- -LRB- 1 -RRB- vs. 1.8 mg dL -LRB- - -RRB- -LRB- 1 -RRB- ; P < 0.01 -RRB- .
21153135	5	-	1067,1068	hCG	1034,1037	-	hCG	null	3342	Chemical	Gene	END_ENTITY|appos|START_ENTITY	Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- .
21153135	5	-	1067,1068	hCG	1039,1042	-	hCG	null	3342	Chemical	Gene	hCG|appos|START_ENTITY END_ENTITY|conj|hCG	Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- .
21153135	5	-	1067,1068	hCG	962,965	-	hCG	null	3342	Chemical	Gene	hCG|appos|START_ENTITY stimulated|nmod|hCG cyclase|acl|stimulated desensitization|nmod|cyclase leads|nmod|desensitization leads|nsubj|treatment treatment|nmod|cells cells|nmod|PMA PMA|conj|END_ENTITY	Furthermore , we show that the treatment of Leydig cells with either PMA or hCG leads to a desensitization of the adenylate cyclase stimulated with hCG , hCG plus GppNHp or AIF -LRB- 4 -RRB- -LRB- - -RRB- .
25640386	11	-	1624,1625	hormone_receptor	1598,1614	-	hormone receptor	null	3164	Chemical	Gene	sensitivity|appos|START_ENTITY sensitivity|nmod|END_ENTITY	Similarly 18F-FDG-PET/CT had higher sensitivity and specificity in hormone_receptor -LRB- + -RRB- and -LRB- - -RRB- groups .
2347471	7	-	1258,1259	Leu7	1245,1249	-	Leu7	null	27087	Chemical	Gene	END_ENTITY|conj|START_ENTITY	In contrast , the population of activated natural killer cells -LRB- CD16 -LRB- + -RRB- and Leu7 -LRB- + -RRB- or -LRB- - -RRB- -RRB- remained below 4 % for the entire period of culture .
24744983	5	-	761,762	mTOR	888,892	-	mTOR	null	2475	Chemical	Gene	8|dep|START_ENTITY include|dep|8 include|dobj|genes genes|acl|involved involved|nmod|signaling signaling|conj|pathways pathways|compound|END_ENTITY	-LRB- 8 -RRB- -LRB- - -RRB- -LRB- 13 -RRB- These networks include genes involved in insulin-like signaling , the heat_shock response , the response to hypoxia , and mTOR and AMPK pathways linked to aging .
27490171	8	-	1512,1513	NTf2	1506,1510	-	NTf2	null	10204	Chemical	Gene	MsO|appos|START_ENTITY MsO|amod|END_ENTITY	The order is found to be as follows : SbF6 -LRB- - -RRB- < BF4 -LRB- - -RRB- < NTf2 -LRB- - -RRB- > ClO4 _ -LRB- - -RRB- > FSO3 _ -LRB- - -RRB- < TfO -LRB- - -RRB- < HSO4 _ -LRB- - -RRB- < Cl -LRB- - -RRB- < MsO -LRB- - -RRB- .
27015986	5	-	944,945	p57	987,990	-	p57	null	12721(Tax:10090)	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|appos|only only|acl|defined defined|dobj|function function|nmod|END_ENTITY	To test this possibility , we generated knock-in mice deficient for p57-mediated cyclin-CDK inhibition -LRB- p57 -LRB- CK -RRB- _ -LRB- - -RRB- -RRB- , the only clearly defined function of p57 .
24778766	5	-	726,727	PTEN	776,780	-	PTEN	null	5728	Chemical	Gene	START_ENTITY|acl:relcl|Understanding Understanding|dobj|mechanisms mechanisms|acl:relcl|modulates modulates|nsubj|END_ENTITY	-LRB- 1 -RRB- -LRB- - -RRB- -LRB- 9 -RRB- Understanding the mechanisms through which PTEN modulates the structure , function , and plasticity of cortical networks is a major focus of study .
1765100	0	+	29,30	ATP-citrate_lyase	87,104	+	ATP-citrate lyase	null	24159(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|dep|difluorocitrate difluorocitrate|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and evaluation of -LRB- + -RRB- and -LRB- - -RRB- -2,2 - difluorocitrate as inhibitors of rat-liver ATP-citrate_lyase and porcine-heart aconitase .
27766923	0	+	105,106	beta_amyloid_peptide	138,158	+	beta amyloid peptide	null	351	Chemical	Gene	compound|appos|START_ENTITY mucronata|conj|compound antiaggregation|nmod|mucronata catechin|nmod|antiaggregation catechin|nmod|END_ENTITY	In vitro antiaggregation and deaggregation potential of Rhizophora mucronata and its bioactive compound -LRB- + -RRB- - catechin against Alzheimer 's beta_amyloid_peptide -LRB- 25-35 -RRB- .
23996432	1	+	279,280	BRAF	217,221	+	BRAF	null	673	Chemical	Gene	investigated|dep|START_ENTITY investigated|dobj|values values|nmod|END_ENTITY	We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients .
28560459	4	+	1367,1368	ERK	1204,1207	+	ERK	null	5594	Chemical	Gene	treated|nsubj|START_ENTITY analysis|acl:relcl|treated detected|nmod|analysis detected|nsubjpass|phosphorylation phosphorylation|dep|kinase kinase|appos|END_ENTITY	The phosphorylation of extracellular signal - regulated kinase -LRB- ERK -RRB- , an important downstream protein of the InsR - mitogen - activated protein kinases -LRB- MAPK -RRB- signaling pathway , was also detected by western blot analysis when -LRB- + -RRB- - PTZ and BD __ -1063 were added to the 80 mmHg - treated cells .
28560459	8	+	1726,1727	ERK	1856,1859	+	ERK	null	5594	Chemical	Gene	decreased|dep|START_ENTITY decreased|conj|increased increased|dobj|R R|conj|phosphorylation phosphorylation|nmod|END_ENTITY	-LRB- + -RRB- - PTZ decreased the apoptosis and death of hTMCs and increased the expression of Sig __ -1 R and InsR , and the phosphorylation of ERK .
28560459	10	+	1952,1953	InsR	2037,2041	+	InsR	null	3643	Chemical	Gene	agonist|appos|START_ENTITY induced|nsubj|agonist induced|advcl|activating activating|dobj|END_ENTITY	The present study suggested that Sig __ -1 R agonist -LRB- + -RRB- - PTZ can protect hTMCs from pressure - induced apoptosis and death by activating InsR and the MAPK signal pathway .
28560459	4	+	1367,1368	InsR	1249,1253	+	InsR	null	3643	Chemical	Gene	treated|nsubj|START_ENTITY analysis|acl:relcl|treated detected|nmod|analysis detected|nsubjpass|phosphorylation phosphorylation|dep|kinase kinase|appos|protein protein|nmod|END_ENTITY	The phosphorylation of extracellular signal - regulated kinase -LRB- ERK -RRB- , an important downstream protein of the InsR - mitogen - activated protein kinases -LRB- MAPK -RRB- signaling pathway , was also detected by western blot analysis when -LRB- + -RRB- - PTZ and BD __ -1063 were added to the 80 mmHg - treated cells .
28560459	8	+	1726,1727	InsR	1823,1827	+	InsR	null	3643	Chemical	Gene	decreased|dep|START_ENTITY decreased|conj|increased increased|dobj|R R|conj|END_ENTITY	-LRB- + -RRB- - PTZ decreased the apoptosis and death of hTMCs and increased the expression of Sig __ -1 R and InsR , and the phosphorylation of ERK .
23996432	1	+	279,280	KRAS	263,267	+	KRAS	null	3845	Chemical	Gene	investigated|dep|START_ENTITY investigated|dobj|values values|nmod|responses responses|nmod|wild-type wild-type|compound|END_ENTITY	We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients .
23996432	1	+	279,280	PI3K	223,227	+	PI3K	null	5293	Chemical	Gene	investigated|dep|START_ENTITY investigated|dobj|values values|nmod|BRAF BRAF|conj|END_ENTITY	We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients .
23996432	1	+	279,280	PTEN	232,236	+	PTEN	null	5728	Chemical	Gene	investigated|dep|START_ENTITY investigated|dobj|values values|nmod|BRAF BRAF|conj|END_ENTITY	We investigated predictive values of BRAF , PI3K and PTEN in cetuximab responses in KRAS wild-type -LRB- + -RRB- chemotherapy refractory , metastatic colorectal_cancer -LRB- CRC -RRB- patients .
28560459	1	+	244,245	Sig-1R	227,233	+	Sig-1R	null	10280	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|receptor receptor|appos|END_ENTITY	The purpose of the present study was to investigate the protective effect of the -1 receptor -LRB- Sig-1R -RRB- agonist -LRB- + -RRB- - pentazocin -LRB- PTZ -RRB- on pressure-induced apoptosis and death of human trabecular meshwork cells -LRB- hTMCs -RRB- .
8836928	2	+	281,282	sigma_1_receptor	309,325	+	sigma 1 receptor	null	29336(Tax:10116)	Chemical	Gene	-LSB-|appos|START_ENTITY -LSB-|dep|END_ENTITY	Acute administration of -LRB- + -RRB- - N-allylnormetazocine -LSB- -LRB- + -RRB- - SKF-10 ,047 -RSB- , a prototype sigma_1_receptor ligand , and 1,3-di -LRB- 2-tolyl -RRB- guanidine -LRB- DTG -RRB- , a non-specific sigma receptor ligand , increased the extracellular ACh level in the rat hippocampus .
20173184	7	0055Leu-Ala0096	947,962	B1-1	914,918	0055Leu-Ala0096	B1-1	MESH:C026526	931	Chemical	Gene	B1-2|dep|START_ENTITY END_ENTITY|conj|B1-2	Region 1 peptides , B1-1 -LRB- 0014Lys-Glu0054 -RRB- and B1-2 -LRB- 0055Leu-Ala0096 -RRB- , mediate transfection of HeLa cells but are cytotoxic .
20173184	7	0055Leu-Ala0096	947,962	B1-2	941,945	0055Leu-Ala0096	B1-2	MESH:C026526	4709;931;28907	Chemical	Gene	END_ENTITY|dep|START_ENTITY	Region 1 peptides , B1-1 -LRB- 0014Lys-Glu0054 -RRB- and B1-2 -LRB- 0055Leu-Ala0096 -RRB- , mediate transfection of HeLa cells but are cytotoxic .
20812894	8	01CM53122	1498,1507	env	1515,1518	01CM53122	env	null	30816	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Further analysis of the 01CM53122 genome showed that this virus represents a diverse set of mosaic genomes from CRF22_01A1 , including a 446-nt segment of 01CM53122 in the env region , but unlike other CRF22 strains , clustered with CRF01_AE rather than the A1 sequence , suggesting that the 01CM53122 strain is a recombinant of CRF22_01A1 and CRF01_AE .
15618722	5	021125Fujieda007	1050,1066	CYP2A13	1079,1086	021125Fujieda007	CYP2A13	null	1553	Chemical	Gene	SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY	SNP , 021125Fujieda007 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - AGTTCAGCGGGCG/AAGGCGAGCAGGC -3 ' .
15618722	7	021125Fujieda017	1296,1312	CYP2A13	1325,1332	021125Fujieda017	CYP2A13	null	1553	Chemical	Gene	SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY	SNP , 021125Fujieda017 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - TCTTTCTCTTCTT/ACACCACCATCAT -3 ' .
15618722	8	021125Fujieda018	1419,1435	CYP2A13	1448,1455	021125Fujieda018	CYP2A13	null	1553	Chemical	Gene	SNP|appos|START_ENTITY SNP|dep|NAME NAME|appos|END_ENTITY	SNP , 021125Fujieda018 ; GENE NAME , CYP2A13 ; ACCESSION NUMBER , NG_000008 ; LENGTH , 25 base ; 5 ' - AGCTTCCTGCCCC/TGCTGAGCGAGGG -3 ' .
11261925	5	0214/02142	785,795	HLA-A	779,784	0214/02142	HLA-A	MESH:C423265	3105	Chemical	Gene	elution|dep|START_ENTITY determined|nmod|elution determined|dobj|motif motif|nmod|END_ENTITY	We have determined the peptide-binding motif of HLA-A * 0214/02142 by peptide elution and bulk Edman degradative sequencing .
1690769	2	0249F	296,301	CD1b	316,320	0249F	CD1b	null	910	Chemical	Gene	START_ENTITY|conj|END_ENTITY	Both 0249F and NU-T2 two CD1b specific mAb tested , induced a rapid increase in the intracellular Ca2 + concentration on HPBALL T cells whereas only one -LRB- L161 -RRB- among three different CD1c mAb -LRB- L161 , 10C3 , and M241 -RRB- produced a similar effect .
1690769	2	0249F	296,301	CD1c	471,475	0249F	CD1c	null	911	Chemical	Gene	START_ENTITY|acl:relcl|tested tested|dep|induced induced|advcl|mAb mAb|nsubj|one one|nmod|END_ENTITY	Both 0249F and NU-T2 two CD1b specific mAb tested , induced a rapid increase in the intracellular Ca2 + concentration on HPBALL T cells whereas only one -LRB- L161 -RRB- among three different CD1c mAb -LRB- L161 , 10C3 , and M241 -RRB- produced a similar effect .
16547398	5	050824FujitaK001	520,536	UGT1A9	549,555	050824FujitaK001	UGT1A9	MESH:D011188	54600	Chemical	Gene	SNP|appos|START_ENTITY SNP|dep|Name Name|appos|END_ENTITY	The sequence is as follows : SNP , 050824FujitaK001 ; Gene Name , UGT1A9 ; Accession Number , AF297093 ; Length , 25 bases ; 5 ' - CCTTCTTGAAGAT/CATGTATTTATAA -3 ' .
16547397	5	050824FujitaK002	380,396	UGT1A7	409,415	050824FujitaK002	UGT1A7	MESH:D011188	54577	Chemical	Gene	SNP|appos|START_ENTITY SNP|dep|Name Name|appos|END_ENTITY	The sequence is as follows : SNP , 050824FujitaK002 ; Gene Name , UGT1A7 ; Accession Number , AF297093 ; Length , 25 bases ; 5 ' - TAAAGGAGAGTTG/CTTTTGATGCAGT -3 ' .
14564379	6	0-5-10-15_cmH2O	689,704	CPAP	676,680	0-5-10-15 cmH2O	CPAP	null	55835	Chemical	Gene	levels|dep|START_ENTITY levels|amod|END_ENTITY	Three gas flow rates -LRB- 20-30-40 l/min and 30-45-60 l/min , respectively , for CPAPM and CPAPH -RRB- and four CPAP levels -LRB- 0-5-10-15_cmH2O -RRB- were employed in a randomized sequence .
20657724	5	0524KO	1474,1480	PGN_0524	1535,1543	0524KO	PGN_0524	MESH:C518174	6329742(Tax:431947)	Chemical	Gene	strain|amod|START_ENTITY strain|acl:relcl|bears bears|dobj|deletion deletion|nmod|locus locus|nummod|END_ENTITY	The resulting mutant strain , designated 0524-Tn4400 ' , was highly sensitive to PMB killing relative to wild-type P. _ gingivalis , and exhibited the same sensitivity as the previously characterized strain , 0524KO , which bears a genetically engineered deletion in the PGN_0524 locus .
17533713	10	05DJ14006	1449,1458	Y0203	1566,1571	05DJ14006	Y0203	null	1145150(Tax:187410)	Chemical	Gene	No.|nummod|START_ENTITY Municipality|dep|No. Commission|nmod|Municipality Foundation|conj|Commission Foundation|conj|Grant Grant|nmod|Committee Committee|dep|No. No.|appos|END_ENTITY	Supported by National Natural Science Foundation of China -LRB- Grant No. 30400502 -RRB- , Science and Technology Commission of Shanghai Municipality -LRB- Grant No. 04dz05601 , 05DJ14006 , 055407034 , 05QMoX14o6 -RRB- and Research Grant from Shanghai Education Committee -LRB- Grant No. 03BC39 , 04YQHB081 , Y0203 -RRB- .
17329912	4	060825Shimizu004	856,872	FMO3	885,889	060825Shimizu004	FMO3	null	2328	Chemical	Gene	follows|parataxis|START_ENTITY follows|parataxis|TATCCAGTGTAAA/GTAAACATCCTGA TATCCAGTGTAAA/GTAAACATCCTGA|nsubj|NAME NAME|appos|END_ENTITY	These sequences are as follows : 1 -RRB- SNP , 060825Shimizu004 ; GENE NAME , FMO3 ; ACCESSION NUMBER , AL021026 ; LENGTH , 25 base ; 5 ' - TATCCAGTGTAAA/GTAAACATCCTGA -3 ' .
17329912	6	060825Shimizu006	1102,1118	FMO3	1131,1135	060825Shimizu006	FMO3	null	2328	Chemical	Gene	START_ENTITY|dep|NAME NAME|appos|END_ENTITY	3 -RRB- SNP , 060825Shimizu006 ; GENE NAME , FMO3 ; ACCESSION NUMBER , AL021026 ; LENGTH , 25 base ; 5 ' - TGTAGTCCCTACC/TAGTTTAGGCTGG -3 ' .
26475632	4	0-6-methylguanine	778,795	b-catenin	764,773	0-6-methylguanine	b-catenin	null	1499	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	BRAF	658,662	0-6-methylguanine	BRAF	null	673	Chemical	Gene	b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin immunostained|nmod|methyltransferase examined|conj|immunostained examined|nmod|mutations mutations|compound|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	KRAS	667,671	0-6-methylguanine	KRAS	null	3845	Chemical	Gene	b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin immunostained|nmod|methyltransferase examined|conj|immunostained examined|nmod|mutations mutations|compound|BRAF BRAF|conj|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	MGMT	819,823	0-6-methylguanine	MGMT	null	4255	Chemical	Gene	b-catenin|conj|START_ENTITY methyltransferase|compound|b-catenin methyltransferase|appos|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	MLH1	748,752	0-6-methylguanine	MLH1	null	4292	Chemical	Gene	b-catenin|conj|START_ENTITY b-catenin|compound|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	p16	759,762	0-6-methylguanine	p16	null	1029	Chemical	Gene	b-catenin|conj|START_ENTITY b-catenin|conj|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
26475632	4	0-6-methylguanine	778,795	p53	754,757	0-6-methylguanine	p53	null	7157	Chemical	Gene	b-catenin|conj|START_ENTITY b-catenin|conj|END_ENTITY	Samples were examined for BRAF and KRAS mutations , the CpG island methylator phenotype -LRB- CIMP -RRB- and immunostained for MLH1 , p53 , p16 , b-catenin and 0-6-methylguanine DNA methyltransferase -LRB- MGMT -RRB- .
21473113	8	06-methylguanine	1170,1186	MMR	1190,1193	06-methylguanine	MMR	null	50771(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	DNA ds-breakes appeared downstream ss-breakes were attributed to repair of 06-methylguanine by MMR mechanism in PHA-stimulated lymphocytes .
23144384	2	08BA02176	513,522	S0385	648,653	08BA02176	S0385	null	1076824(Tax:198215)	Chemical	Gene	isolate|appos|START_ENTITY sequence|nmod|isolate acquired|nsubjpass|sequence acquired|nmod|genome genome|nmod|isolate isolate|appos|END_ENTITY	In this study , the complete genome sequence of a Canadian representative LA-MRSA isolate -LRB- 08BA02176 -RRB- from a human postoperative surgical site infection was acquired and compared to the sequenced genome of an LA-MRSA isolate -LRB- S0385 -RRB- from Europe to identify genetic traits that may explain differences in the success of these particular strains in some locales .
25374426	9	08-IMC	1256,1262	CCR5	1297,1301	08-IMC	CCR5	null	1234	Chemical	Gene	infect|nsubj|START_ENTITY infect|dep|expressing expressing|dobj|END_ENTITY	08-IMC could infect the cells expressing CCR5 and be replicated in the CCR5-expressing cells with a positive percentage of 24.3 % , 08-ISO may use CCR5-using macrophage-tropic isolates as coreceptor , while pNL4-3 viruses with T cell tropisms utilize the CXCR4 co-receptor .
25374426	9	08-IMC	1256,1262	CXCR4	1510,1515	08-IMC	CXCR4	null	7852	Chemical	Gene	infect|nsubj|START_ENTITY use|ccomp|infect use|advcl|utilize utilize|dobj|co-receptor co-receptor|compound|END_ENTITY	08-IMC could infect the cells expressing CCR5 and be replicated in the CCR5-expressing cells with a positive percentage of 24.3 % , 08-ISO may use CCR5-using macrophage-tropic isolates as coreceptor , while pNL4-3 viruses with T cell tropisms utilize the CXCR4 co-receptor .
25374426	5	08-IMC	759,765	p24	731,734	08-IMC	p24	null	10959	Chemical	Gene	generated|nmod|START_ENTITY antigens|acl|generated antigens|amod|END_ENTITY	HIV-1 p24 antigens generated from 08-IMC were slightly greater than those from infectious molecular clones pNL4-3 3 and 93JP-NH1 , but without statistical difference -LRB- all P > 0.05 -RRB- .
18162524	7	0900-0900	1214,1223	leptin	1167,1173	0900-0900	leptin	MESH:C523421	443534(Tax:9940)	Chemical	Gene	infusion|appos|START_ENTITY infusion|nmod|ventricle ventricle|nmod|vehicle vehicle|conj|END_ENTITY	Intracerebroventricular infusion into the lateral ventricle of either vehicle -LRB- artificial cerebrospinal fluid -RRB- or leptin -LRB- 10 microg/h at 100 microl/h -RRB- for 24 h -LRB- 0900-0900 -RRB- was performed in a cross-over design with a 1-wk recovery period between treatments .
26923241	1	0CHCH2	221,227	CF2	213,216	0CHCH2	CF2	null	537	Chemical	Gene	>|ccomp|START_ENTITY x|acl|> CF3|dep|x CF3|appos|END_ENTITY	Hydrofluoroolefins -LRB- HFOs -RRB- of the type CF3 -LRB- CF2 -RRB- x > = 0CHCH2 , are currently being suggested as substitutes of some hydrofluorocarbons -LRB- HFCs -RRB- .
6145159	5	0-diazo-acetyl-L-serine	689,712	glutamine_synthetase	962,982	0-diazo-acetyl-L-serine	glutamine synthetase	null	14645(Tax:10090)	Chemical	Gene	6-diazo-5-oxo-L-norleucine|conj|START_ENTITY isoxazolidone|amod|6-diazo-5-oxo-L-norleucine inhibitors|appos|isoxazolidone protected|nsubj|inhibitors protected|advcl|exacerbated exacerbated|nsubj|pyridoxal-5 pyridoxal-5|appos|inhibitor inhibitor|amod|END_ENTITY	Glutaminase inhibitors , 6-diazo-5-oxo-L-norleucine -LRB- DON -RRB- and 0-diazo-acetyl-L-serine -LRB- azaserine -RRB- , and a transaminase inhibitor , 4-amino-3 - _ isoxazolidone -LRB- L-cycloserine -RRB- , when injected intraperitoneally , protected the seizure-susceptible mouse from undergoing convulsions , whereas pyridoxal-5 ' - phosphate and methionine_sulphoximine , a glutamine_synthetase inhibitor , exacerbated its epileptic_condition .
1041590	4	0-nitrophenyl-beta-D-galactopyranoside	606,644	ornithine_decarboxylase	649,672	0-nitrophenyl-beta-D-galactopyranoside	ornithine decarboxylase	null	4953	Chemical	Gene	START_ENTITY|conj|END_ENTITY	Two newly developed test strips , for 0-nitrophenyl-beta-D-galactopyranoside and ornithine_decarboxylase , were found to be highly reliable .
1238112	7	0-nitrophenyl-sulfenyl_chloride	1292,1323	phospholipase_A2	1223,1239	0-nitrophenyl-sulfenyl chloride	phospholipase A2	null	5319	Chemical	Gene	using|xcomp|START_ENTITY sulfenylated|xcomp|using sulfenylated|nsubjpass|residue residue|nmod|END_ENTITY	The single Trp10 residue in native phospholipase_A2 and its zymogen was specifically sulfenylated using 0-nitrophenyl-sulfenyl_chloride .
9018469	3	0OH	690,693	CO2	639,642	0OH	CO2	null	717	Chemical	Gene	H2O2|conj|START_ENTITY H2O2|dep|acetate acetate|conj|END_ENTITY	Data obtained indicate that consumption of H2O2 by pyruvate -LRB- generating acetate and CO2 via an oxidative decarboxylation reaction -RRB- and 0OH radical by lactate -LRB- generating pyruvate , and subsequently acetate and CO2 -RRB- may serve to protect alternative biofluid components -LRB- e.g. , macromolecules -RRB- against reactive oxygen species-mediated oxidative damage in vivo .
19833204	8	0S-2-3-4-5-6-7-8	1208,1224	ERalpha	1264,1271	0S-2-3-4-5-6-7-8	ERalpha	null	24890(Tax:10116)	Chemical	Gene	variants|appos|START_ENTITY variants|dep|proteins proteins|compound|END_ENTITY	Moreover , we determined a splicing event to yield Deltaexon 1 variants -LRB- 0S-2-3-4-5-6-7-8 -RRB- , which are translated into rat 46 kDa ERalpha proteins .
20543109	6	1001-1013	821,830	IFN-beta	886,894	1001-1013	IFN-beta	MESH:C013844	15977(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY increased|nsubj|pJAK2 increased|dobj|level level|nmod|END_ENTITY	pJAK2 -LRB- 1001-1013 -RRB- increased the intracellular level of the constitutive IFN-beta , which may play a role in the antagonist antiviral effect at the cellular level .
17404288	10	1001-1013	1580,1589	IFN-gamma	1611,1620	1001-1013	IFN-gamma	MESH:C013844	15978(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY pJAK2|dep|activity activity|amod|END_ENTITY	Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation .
17404288	10	1001-1013	1580,1589	IFN-gamma	1722,1731	1001-1013	IFN-gamma	MESH:C013844	15978(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY blocked|nsubj|pJAK2 blocked|nmod|cells cells|conj|activity activity|compound|END_ENTITY	Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation .
20543109	8	1001-1013	1131,1140	IFN-gamma	1175,1184	1001-1013	IFN-gamma	MESH:C013844	15978(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY synergizes|nsubj|pJAK2 synergizes|nmod|IFNs IFNs|nmod|mimetic mimetic|amod|END_ENTITY	pJAK2 -LRB- 1001-1013 -RRB- also synergizes with IFNs as per IFN-gamma mimetic to exert a multiplicative antiviral effect at the level of transcription , the cell , and protection of mice against lethal viral_infection .
20543109	9	1001-1013	1338,1347	IFN-gamma	1456,1465	1001-1013	IFN-gamma	MESH:C013844	15978(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|conj|blocks blocks|nmod|promoter promoter|amod|END_ENTITY	pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter .
17404288	9	1001-1013	1483,1492	JAK2	1512,1516	1001-1013	JAK2	MESH:C013844	16452(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY binds|nmod|pJAK2 fact|dep|binds suggests|nsubj|fact suggests|ccomp|function function|nsubj|peptide peptide|compound|END_ENTITY	The fact that SOCS1-KIR binds to pJAK2 -LRB- 1001-1013 -RRB- suggests that the JAK2 peptide could function as an antagonist of SOCS-1 .
17404288	9	1001-1013	1483,1492	SOCS-1	1560,1566	1001-1013	SOCS-1	MESH:C013844	12703(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY binds|nmod|pJAK2 fact|dep|binds suggests|nsubj|fact suggests|ccomp|function function|nmod|antagonist antagonist|nmod|END_ENTITY	The fact that SOCS1-KIR binds to pJAK2 -LRB- 1001-1013 -RRB- suggests that the JAK2 peptide could function as an antagonist of SOCS-1 .
20543109	9	1001-1013	1338,1347	SOCS-1	1395,1401	1001-1013	SOCS-1	MESH:C013844	12703(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|nmod|region region|nmod|END_ENTITY	pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter .
20543109	9	1001-1013	1338,1347	SOCS-3	1406,1412	1001-1013	SOCS-3	MESH:C013844	12702(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY binds|nsubj|pJAK2 binds|nmod|region region|nmod|SOCS-1 SOCS-1|conj|END_ENTITY	pJAK2 -LRB- 1001-1013 -RRB- binds to the kinase inhibitory region of both SOCS-1 and SOCS-3 and blocks their inhibitory effects on the IFN-gamma activation site promoter .
17404288	10	1001-1013	1580,1589	STAT3	1668,1673	1001-1013	STAT3	MESH:C013844	20848(Tax:10090)	Chemical	Gene	pJAK2|appos|START_ENTITY blocked|nsubj|pJAK2 blocked|dobj|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Thus , pJAK2 -LRB- 1001-1013 -RRB- enhanced suboptimal IFN-gamma activity , blocked SOCS-1-induced inhibition of STAT3 phosphorylation in IL-6-treated cells , enhanced IFN-gamma activation site promoter activity , and enhanced Ag-specific proliferation .
9210654	10	10014-10018	1316,1327	P450	1380,1384	10014-10018	P450	MESH:C000192	1583	Chemical	Gene	USA|amod|START_ENTITY USA|nmod|activity activity|nmod|P450c27 P450c27|appos|END_ENTITY	USA 91 , 10014-10018 -RRB- because this activity of P450c27 -LRB- 28 pmol/min/nmol P450 -RRB- seems far too low to be physiologically relevant .
9210654	10	10014-10018	1316,1327	P450c27	1354,1361	10014-10018	P450c27	MESH:C000192	301517(Tax:10116)	Chemical	Gene	USA|amod|START_ENTITY USA|nmod|activity activity|nmod|END_ENTITY	USA 91 , 10014-10018 -RRB- because this activity of P450c27 -LRB- 28 pmol/min/nmol P450 -RRB- seems far too low to be physiologically relevant .
1751497	11	10041-10047	2283,2294	PLA2	2379,2383	10041-10047	PLA2	MESH:C012134	104974671	Chemical	Gene	-RSB-|nummod|START_ENTITY -RSB-|dep|step step|nmod|catalysis catalysis|nmod|END_ENTITY	264 , 10041-10047 -RSB- that substrate-level acylation of Lys-56 is an obligatory step in the catalysis by PLA2 .
18156631	11	10042-10051	1352,1363	ADAMTS-4	1440,1448	10042-10051	ADAMTS-4	MESH:C098805	9507	Chemical	Gene	279|amod|START_ENTITY 279|appos|investigation investigation|nmod|role role|nmod|domain domain|nmod|END_ENTITY	279 , 10042-10051 -RRB- , our detailed investigation of the role of the C-terminal spacer domain of ADAMTS-4 indicated that full-length ADAMTS-4 is approximately 20-times more active against aggrecan than its spacer domain deletion mutant , even at the Glu373-Ala374 site of the interglobular domain .
18156631	11	10042-10051	1352,1363	ADAMTS-4	1476,1484	10042-10051	ADAMTS-4	MESH:C098805	9507	Chemical	Gene	279|amod|START_ENTITY indicated|nsubj|279 indicated|ccomp|20-times 20-times|nsubj|END_ENTITY	279 , 10042-10051 -RRB- , our detailed investigation of the role of the C-terminal spacer domain of ADAMTS-4 indicated that full-length ADAMTS-4 is approximately 20-times more active against aggrecan than its spacer domain deletion mutant , even at the Glu373-Ala374 site of the interglobular domain .
15625830	0	1004C	14,19	G6PD	26,30	1004C	G6PD	null	2539	Chemical	Gene	_|nummod|START_ENTITY case|nmod|_ -LSB-|dobj|case -LSB-|parataxis|_ _|dobj|mutation mutation|compound|END_ENTITY	-LSB- A case of nt 1004C _ -- > _ A G6PD gene mutation in Yunnan Han people -RSB- .
12626421	2	100-4G11-A	458,468	phospholipase_A2	645,661	100-4G11-A	phospholipase A2	MESH:C420352	18778(Tax:10090)	Chemical	Gene	mAb|appos|START_ENTITY selected|nsubjpass|mAb selected|nmod|panel panel|nmod|mAbs mAbs|acl|generated generated|advcl|recognized recognized|ccomp|horseradish horseradish|xcomp|peroxidase peroxidase|conj|END_ENTITY	An IgM mAb -LRB- 100-4G11-A -RRB- was selected from a panel of anti-glycan mAbs generated from Schistosoma-infected or immunized mice because it recognized both a plant glycoprotein horseradish peroxidase and phospholipase_A2 from honeybee venom .
26038891	3	10058F4	319,326	Myc	344,347	10058F4	Myc	null	4609	Chemical	Gene	arsenic_trioxide|conj|START_ENTITY arsenic_trioxide|appos|inhibitor inhibitor|nmod|END_ENTITY	We found that both arsenic_trioxide and 10058F4 , an inhibitor of Myc , induced differentiation of cancer stem-like cells -LRB- CSC -RRB- of GBM and that arsenic_trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects .
26038891	3	10058F4	492,499	Myc	344,347	10058F4	Myc	null	4609	Chemical	Gene	effect|nmod|START_ENTITY enhanced|dobj|effect induced|conj|enhanced induced|nsubj|arsenic_trioxide arsenic_trioxide|appos|inhibitor inhibitor|nmod|END_ENTITY	We found that both arsenic_trioxide and 10058F4 , an inhibitor of Myc , induced differentiation of cancer stem-like cells -LRB- CSC -RRB- of GBM and that arsenic_trioxide drastically enhanced the anti-proliferative effect of 10058F4 but not apoptotic effects .
25689483	10	10058-F4	1547,1555	ABCB5	1580,1585	10058-F4	ABCB5	null	77706(Tax:10090)	Chemical	Gene	treatment|nummod|START_ENTITY decreased|nsubj|treatment decreased|dobj|level level|compound|END_ENTITY	10058-F4 treatment decreased the ABCB5 expression level in the presence or absence of 5-FU .
25689483	7	10058-F4	1045,1053	ABCB5	1096,1101	10058-F4	ABCB5	null	340273	Chemical	Gene	inhibited|dep|START_ENTITY inhibited|nmod|promoter promoter|compound|END_ENTITY	c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level .
25689483	7	10058-F4	1045,1053	ABCB5	1137,1142	10058-F4	ABCB5	null	340273	Chemical	Gene	inhibited|dep|START_ENTITY inhibited|advcl|leading leading|nmod|decrease decrease|nmod|level level|compound|END_ENTITY	c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level .
17159602	7	10058-F4	952,960	alpha-fetoprotein	994,1011	10058-F4	alpha-fetoprotein	null	174	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|levels levels|amod|END_ENTITY	Besides , 10058-F4 also significantly decreased the alpha-fetoprotein levels , an indicator for hepatocellular_carcinoma differentiation .
25143136	5	10058-F4	758,766	Annexin_V	721,730	10058-F4	Annexin V	null	308	Chemical	Gene	inhibited|nsubj|START_ENTITY found|ccomp|inhibited found|advcl|Using Using|dobj|cytometry cytometry|conj|assays assays|compound|END_ENTITY	Using MTT assay , colony formation , flow cytometry and Annexin_V FITC assays , we found that 10058-F4 significantly inhibited cell proliferation of both SKOV3 and Hey ovarian_cancer cells in a dose dependent manner through induction of apoptosis and cell cycle G1 arrest .
17046567	6	10058-F4	943,951	Bax	1064,1067	10058-F4	Bax	MESH:C524814	581	Chemical	Gene	apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|upregulation upregulation|nmod|END_ENTITY	Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 .
17046567	6	10058-F4	943,951	Bcl-2	1041,1046	10058-F4	Bcl-2	MESH:C524814	596	Chemical	Gene	apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|nmod|END_ENTITY	Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 .
21640157	6	10058-F4	1230,1238	Bcl-2	1219,1224	10058-F4	Bcl-2	null	596	Chemical	Gene	ABT-263|conj|START_ENTITY ABT-263|conj|inhibitor inhibitor|nmod|END_ENTITY	Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition .
21640157	6	10058-F4	1230,1238	Bcl-2	1350,1355	10058-F4	Bcl-2	null	596	Chemical	Gene	ABT-263|conj|START_ENTITY Using|dobj|ABT-263 found|advcl|Using found|ccomp|sensitive sensitive|nmod|death death|nmod|result result|nmod|inhibition inhibition|compound|END_ENTITY	Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition .
17046567	6	10058-F4	943,951	caspase_3	1122,1131	10058-F4	caspase 3	MESH:C524814	836	Chemical	Gene	apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|cleavage cleavage|nmod|END_ENTITY	Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 .
25143136	7	10058-F4	1094,1102	caspase-3	1123,1132	10058-F4	caspase-3	null	836	Chemical	Gene	treated|nmod|START_ENTITY ovarian_cancer|acl|treated cultures|nmod|ovarian_cancer showed|nsubj|cultures showed|dobj|induction induction|nmod|activity activity|amod|END_ENTITY	Consistently , primary cultures of ovarian_cancer treated with 10058-F4 showed induction of caspase-3 activity and inhibition of cell proliferation in 15 of 18 cases .
16410134	6	10058-F4	590,598	c-Myc	564,569	10058-F4	c-Myc	MESH:C524814	24577(Tax:10116)	Chemical	Gene	compound|nummod|START_ENTITY inhibitor|appos|compound inhibitor|amod|END_ENTITY	Growth effects of a c-Myc inhibitor , compound 10058-F4 , were determined in these 4 lines using 3 - -LRB- 4,5-dimethylthiazol-2-yl -RRB- -2,5 - diphenyltetrazolium_bromide analyses and direct cell counts .
17046567	0	10058-F4	34,42	c-Myc	17,22	10058-F4	c-Myc	MESH:C524814	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A small-molecule c-Myc inhibitor , 10058-F4 , induces cell-cycle arrest , apoptosis , and myeloid differentiation of human acute_myeloid_leukemia .
17046567	5	10058-F4	812,820	c-Myc	870,875	10058-F4	c-Myc	MESH:C524814	4609	Chemical	Gene	cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|dobj|expression expression|amod|END_ENTITY	RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 .
17159602	0	10058-F4	32,40	c-Myc	15,20	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Small-molecule c-Myc inhibitor , 10058-F4 , inhibits proliferation , downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular_carcinoma cells .
17159602	3	10058-F4	467,475	c-Myc	450,455	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The potential of using small-molecule c-Myc inhibitor , 10058-F4 , was evaluated on hepatocellular_carcinoma cell lines , HepG2 and Hep3B cells .
17159602	4	10058-F4	589,597	c-Myc	702,707	10058-F4	c-Myc	null	4609	Chemical	Gene	sensitive|nmod|START_ENTITY sensitive|advcl|demonstrated demonstrated|nmod|viability viability|conj|levels levels|amod|END_ENTITY	HepG2 cells were more sensitive to 10058-F4 than Hep3B cells , as demonstrated by reduced cell viability , marked morphological changes and decreased c-Myc levels .
19114306	3	10058-F4	402,410	c-Myc	451,456	10058-F4	c-Myc	null	4609	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|small-molecule small-molecule|dep|disordered disordered|dobj|monomers monomers|amod|END_ENTITY	We show that the effect of 10058-F4 -LRB- a small-molecule that binds disordered c-Myc monomers and disrupts the c-Myc-Max complex -RRB- on both c-Myc-Max heterodimerization and DNA binding is dependent on the nature of the Max isoform .
19180571	4	10058-F4	770,778	c-Myc	754,759	10058-F4	c-Myc	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	JAK inhibitor AG490 and c-Myc inhibitor 10058-F4 , both , reduced IL-5-mediated cell proliferation in a dose - and time-dependent manner .
20170530	10	10058-F4	1470,1478	c-Myc	1453,1458	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The induction effect of HBx was inhibited after treatment with c-Myc inhibitor , 10058-F4 .
20423888	8	10058-F4	935,943	c-Myc	918,923	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Furthermore , a small-molecule c-Myc inhibitor , 10058-F4 represses PC-1 gene expression in C4-2 cell line .
21618595	6	10058-F4	891,899	c-Myc	874,879	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Furthermore , we found a comparable decrease in proliferation and G0/G1 accumulation of 786-0 and RC-2 cells after treatment with a small molecule c-Myc inhibitor , 10058-F4 .
21640157	6	10058-F4	1230,1238	c-Myc	1257,1262	10058-F4	c-Myc	null	4609	Chemical	Gene	ABT-263|conj|START_ENTITY Using|dobj|ABT-263 Using|advcl|END_ENTITY	Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition .
21640157	6	10058-F4	1230,1238	c-Myc	1375,1380	10058-F4	c-Myc	null	4609	Chemical	Gene	ABT-263|conj|START_ENTITY Using|dobj|ABT-263 found|advcl|Using found|ccomp|sensitive sensitive|nmod|inhibition inhibition|amod|END_ENTITY	Using ABT-263 , an inhibitor for Bcl-2 , and 10058-F4 , an inhibitor for c-Myc , we found that both cell lines were more highly sensitive to cell death as a result of Bcl-2 inhibition than of c-Myc inhibition .
22302044	5	10058-F4	851,859	c-Myc	885,890	10058-F4	c-Myc	null	4609	Chemical	Gene	cells|nmod|START_ENTITY pretreatment|nmod|cells pretreatment|appos|inhibitor inhibitor|nmod|END_ENTITY	Nevertheless , pretreatment of cells with 10058-F4 , a specific inhibitor of c-Myc , almost eliminated the nicotinamide-induced radiosensitive effect .
24124686	6	10058-F4	778,786	c-Myc	762,767	10058-F4	c-Myc	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	After a pre-treatment of c-Myc inhibitor 10058-F4 , the apoptosis of AML cell was also evaluated .
25143136	4	10058-F4	562,570	c-Myc	545,550	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Our objective was to evaluate the potential effects of small-molecule c-Myc inhibitor , 10058-F4 , on ovarian_carcinoma cells and the underlying mechanisms by which 10058-F4 exerts its actions .
25143136	4	10058-F4	638,646	c-Myc	545,550	10058-F4	c-Myc	null	4609	Chemical	Gene	exerts|nsubj|START_ENTITY mechanisms|acl:relcl|exerts cells|conj|mechanisms evaluate|nmod|cells evaluate|dobj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Our objective was to evaluate the potential effects of small-molecule c-Myc inhibitor , 10058-F4 , on ovarian_carcinoma cells and the underlying mechanisms by which 10058-F4 exerts its actions .
25143136	8	10058-F4	1214,1222	c-Myc	1252,1257	10058-F4	c-Myc	null	4609	Chemical	Gene	response|nmod|START_ENTITY independent|nsubj|response independent|dep|level level|nmod|over-expression over-expression|amod|END_ENTITY	The response to 10058-F4 was independent the level of c-Myc protein over-expression in primary cultures of ovarian_carcinoma .
26211592	0	10058-F4	23,31	c-Myc	14,19	10058-F4	c-Myc	null	4609	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Inhibition of c-Myc by 10058-F4 induces growth_arrest and chemosensitivity in pancreatic_ductal_adenocarcinoma .
26211592	3	10058-F4	402,410	c-Myc	385,390	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The c-Myc inhibitor , 10058-F4 , has been reported act as a tumor suppressor in several different tumors .
26548696	9	10058-F4	2233,2241	c-Myc	2187,2192	10058-F4	c-Myc	null	4609	Chemical	Gene	using|dobj|START_ENTITY tested|xcomp|using tested|nsubjpass|role role|nmod|END_ENTITY	The role of c-Myc was tested in vitro using the inhibitor 10058-F4 , which , over time , decreased basal RNA and MPS in a dose-dependent manner -LRB- correlation of RNA and MPS , r -LRB- 2 -RRB- = 0.98 -RRB- , even though it had no effect on the acute stimulation of protein synthesis .
20515470	10	10058-F4	1683,1691	c-MYC	1667,1672	10058-F4	c-MYC	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	The c-MYC inhibitor 10058-F4 suppressed the tumorigenicity of Pim1-expressing prostate_cancer cells .
20515470	15	10058-F4	2317,2325	c-MYC	2301,2306	10058-F4	c-MYC	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	We also made the novel discovery that treatment of cells with the c-MYC inhibitor 10058-F4 leads to a reduction in Pim1 protein levels .
20515470	6	10058-F4	1090,1098	c-MYC	1005,1010	10058-F4	c-MYC	null	4609	Chemical	Gene	inhibitor|appos|START_ENTITY using|dobj|inhibitor c-MYC|dep|using inhibited|xcomp|c-MYC inhibited|advcl|validate validate|ccomp|induces induces|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference .
20515470	6	10058-F4	1090,1098	c-MYC	1050,1055	10058-F4	c-MYC	null	4609	Chemical	Gene	inhibitor|appos|START_ENTITY using|dobj|inhibitor END_ENTITY|dep|using	To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference .
23525267	7	10058-F4	1187,1195	c-MYC	1156,1161	10058-F4	c-MYC	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt_lymphoma cells .
24859015	3	10058-F4	467,475	c-MYC	498,503	10058-F4	c-MYC	null	4609	Chemical	Gene	START_ENTITY|dep|known known|nmod|domain domain|amod|END_ENTITY	We have previously demonstrated that the small molecule 10058-F4 , known to bind to the c-MYC bHLHZip dimerization domain and inhibiting the c-MYC/MAX interaction , also interferes with the MYCN/MAX dimerization in vitro and imparts anti-tumorigenic effects in neuroblastoma_tumor models with MYCN overexpression .
25689483	7	10058-F4	1045,1053	c-MYC	1028,1033	10058-F4	c-MYC	null	4609	Chemical	Gene	inhibited|dep|START_ENTITY inhibited|nsubj|inhibitor inhibitor|amod|END_ENTITY	c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level .
25689483	7	10058-F4	1045,1053	c-MYC	1075,1080	10058-F4	c-MYC	null	4609	Chemical	Gene	inhibited|dep|START_ENTITY inhibited|dobj|binding binding|amod|END_ENTITY	c-MYC inhibitor -LRB- 10058-F4 -RRB- treatment inhibited c-MYC binding to the ABCB5 promoter , leading to a decrease in ABCB5 expression level .
27789709	4	10058-F4	645,653	c-MYC	629,634	10058-F4	c-MYC	null	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- .
27789709	4	10058-F4	645,653	c-MYC	678,683	10058-F4	c-MYC	null	4609	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|END_ENTITY	Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- .
17046567	6	10058-F4	943,951	cytochrome_C	1092,1104	10058-F4	cytochrome C	MESH:C524814	54205	Chemical	Gene	apoptosis|nummod|START_ENTITY shown|nsubj|apoptosis shown|nmod|downregulation downregulation|conj|release release|nmod|END_ENTITY	Meanwhile , 10058-F4 induced apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2 , upregulation of Bax , release of cytoplasmic cytochrome_C , and cleavage of caspase_3 , 7 , and 9 .
24977668	6	10058-F4	896,904	FOXO1	808,813	10058-F4	FOXO1	null	2308	Chemical	Gene	increased|nsubj|START_ENTITY resulted|conj|increased resulted|nmod|upregulation upregulation|nmod|mRNA mRNA|compound|END_ENTITY	Targeting JAK2 activity by the small molecular weight inhibitor TG101348 resulted in upregulation of FOXO1 mRNA and protein expression in MedB-1 and U2940 cell lines , and the MYC inhibitor 10058-F4 increased FOXO1 mRNA in MedB-1 cells .
23525267	7	10058-F4	1187,1195	GLI1	1210,1214	10058-F4	GLI1	null	2735	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|mRNA mRNA|amod|END_ENTITY	The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt_lymphoma cells .
20170530	10	10058-F4	1470,1478	HBx	1414,1417	10058-F4	HBx	null	944566(Tax:10407)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubjpass|effect effect|nmod|END_ENTITY	The induction effect of HBx was inhibited after treatment with c-Myc inhibitor , 10058-F4 .
24977668	6	10058-F4	896,904	JAK2	717,721	10058-F4	JAK2	null	3717	Chemical	Gene	increased|nsubj|START_ENTITY resulted|conj|increased resulted|csubj|Targeting Targeting|dobj|activity activity|compound|END_ENTITY	Targeting JAK2 activity by the small molecular weight inhibitor TG101348 resulted in upregulation of FOXO1 mRNA and protein expression in MedB-1 and U2940 cell lines , and the MYC inhibitor 10058-F4 increased FOXO1 mRNA in MedB-1 cells .
17942906	2	10058-F4	147,155	MYC	212,215	10058-F4	MYC	null	4609	Chemical	Gene	Using|dobj|START_ENTITY down-regulated|advcl|Using down-regulated|nsubjpass|compound compound|acl:relcl|inhibits inhibits|dobj|factor factor|conj|protein protein|compound|END_ENTITY	Using 10058-F4 , a compound that inhibits MYC-MAX transcription factor , MYC protein and gene expression were down-regulated in Namalwa cells , a Burkitt_lymphoma .
24859015	3	10058-F4	467,475	MYCN	702,706	10058-F4	MYCN	null	4613	Chemical	Gene	interferes|nsubj|START_ENTITY interferes|nmod|overexpression overexpression|compound|END_ENTITY	We have previously demonstrated that the small molecule 10058-F4 , known to bind to the c-MYC bHLHZip dimerization domain and inhibiting the c-MYC/MAX interaction , also interferes with the MYCN/MAX dimerization in vitro and imparts anti-tumorigenic effects in neuroblastoma_tumor models with MYCN overexpression .
24859015	7	10058-F4	1536,1544	MYCN	1473,1477	10058-F4	MYCN	null	4613	Chemical	Gene	metabolite|amod|START_ENTITY found|nmod|metabolite found|dobj|interaction interaction|nmod|END_ENTITY	Using a proximity ligation assay , we found reduced interaction between MYCN and MAX after treatment with all molecules except for the 10058-F4 metabolite C-m/z 232 and the non-binder 10058-F4 -LRB- 7RH -RRB- .
24859015	7	10058-F4	1585,1593	MYCN	1473,1477	10058-F4	MYCN	null	4613	Chemical	Gene	metabolite|conj|START_ENTITY found|nmod|metabolite found|dobj|interaction interaction|nmod|END_ENTITY	Using a proximity ligation assay , we found reduced interaction between MYCN and MAX after treatment with all molecules except for the 10058-F4 metabolite C-m/z 232 and the non-binder 10058-F4 -LRB- 7RH -RRB- .
17046567	5	10058-F4	812,820	p21	919,922	10058-F4	p21	MESH:C524814	644914	Chemical	Gene	cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|conj|upregulated upregulated|xcomp|inhibitors inhibitors|conj|END_ENTITY	RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 .
17046567	5	10058-F4	812,820	p27	927,930	10058-F4	p27	MESH:C524814	10671	Chemical	Gene	cells|nummod|START_ENTITY downregulated|nsubj|cells downregulated|conj|upregulated upregulated|xcomp|inhibitors inhibitors|conj|END_ENTITY	RESULTS : We showed that 10058-F4 arrested AML cells at G0/G1 phase , downregulated c-Myc expression and upregulated CDK inhibitors , p21 and p27 .
20515470	11	10058-F4	1779,1787	Pim1	1825,1829	10058-F4	Pim1	null	5292	Chemical	Gene	treatment|nummod|START_ENTITY led|nsubj|treatment led|nmod|reduction reduction|nmod|protein protein|amod|END_ENTITY	Interestingly , 10058-F4 treatment also led to a reduction of Pim1 protein but not mRNA .
20515470	15	10058-F4	2317,2325	Pim1	2350,2354	10058-F4	Pim1	null	5292	Chemical	Gene	cells|nmod|START_ENTITY treatment|nmod|cells leads|nsubj|treatment leads|nmod|reduction reduction|nmod|levels levels|amod|END_ENTITY	We also made the novel discovery that treatment of cells with the c-MYC inhibitor 10058-F4 leads to a reduction in Pim1 protein levels .
20515470	6	10058-F4	1090,1098	Pim1	936,940	10058-F4	Pim1	null	5292	Chemical	Gene	inhibitor|appos|START_ENTITY using|dobj|inhibitor c-MYC|dep|using inhibited|xcomp|c-MYC inhibited|advcl|validate validate|ccomp|induces induces|nsubj|END_ENTITY	To validate that Pim1 induces tumorigenicity and target gene expression by modulating c-MYC transcriptional activity , we inhibited c-MYC using a small molecule inhibitor -LRB- 10058-F4 -RRB- or RNA interference .
27789709	4	10058-F4	645,653	PRC	685,688	10058-F4	PRC	null	23082	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|c-MYC c-MYC|conj|END_ENTITY	Here , we show that the c-MYC inhibitor 10058-F4 blocks the induction of c-MYC , PRC , and representative PRC-dependent stress genes by the respiratory chain uncoupler , carbonyl_cyanide_m-chlorophenyl_hydrazine -LRB- CCCP -RRB- .
27031051	9	10058-F4	1169,1177	TRPM8	1223,1228	10058-F4	TRPM8	null	171382(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY prevented|nsubj|administration prevented|dobj|cold_allodynia cold_allodynia|conj|increase increase|nmod|mRNA mRNA|compound|END_ENTITY	Prophylactic administration of the c-Myc inhibitor 10058-F4 prevented cold_allodynia and the increase of TRPM8 mRNA after oxaliplatin injection .
9173919	4	1006-amino-acid	580,595	atrophin-1	817,827	1006-amino-acid	atrophin-1	null	29515(Tax:10116)	Chemical	Gene	product|amod|START_ENTITY contain|nsubj|product contain|conj|contain contain|dobj|regions regions|acl|alternating alternating|xcomp|similar similar|nmod|those those|acl|found found|advcl|END_ENTITY	The 1006-amino-acid product of this gene , which we have termed rat atrophin related protein -LRB- rARP -RRB- , does not contain a glutamine repeat , but it does contain two regions of alternating acidic and basic amino residues similar to those found in atrophin-1 .
18984437	5	1006_Framingham_offspring	863,888	MMP-9	768,773	1006 Framingham offspring	MMP-9	MESH:C076134	4318	Chemical	Gene	carotid|nmod|START_ENTITY PIIINP|advcl|carotid related|conj|PIIINP related|xcomp|circulating circulating|dobj|END_ENTITY	METHODS : We related circulating MMP-9 , TIMP-1 , and/or PIIINP concentrations to carotid atherosclerosis on duplex ultrasound in 1006_Framingham_offspring -LRB- mean age 58 years , 56 % women -RRB- who attended a routine examination from 1995 to 1998 .
18984437	5	1006_Framingham_offspring	863,888	TIMP-1	775,781	1006 Framingham offspring	TIMP-1	MESH:C076134	7076	Chemical	Gene	carotid|nmod|START_ENTITY PIIINP|advcl|carotid related|conj|PIIINP related|xcomp|circulating circulating|dobj|MMP-9 MMP-9|appos|END_ENTITY	METHODS : We related circulating MMP-9 , TIMP-1 , and/or PIIINP concentrations to carotid atherosclerosis on duplex ultrasound in 1006_Framingham_offspring -LRB- mean age 58 years , 56 % women -RRB- who attended a routine examination from 1995 to 1998 .
24098099	4	10074-A4	762,770	c-Myc	664,669	10074-A4	c-Myc	null	4609	Chemical	Gene	ligand|dep|START_ENTITY peptide|amod|ligand peptide|amod|END_ENTITY	To better understand the structure of IDPs and their interactions with small molecule ligands , we performed extensive simulations on the c-Myc peptide and its binding to a reported small molecule inhibitor , ligand 10074-A4 .
19022175	2	10074-G5	443,451	c-Myc	458,463	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	10058-F4|conj|START_ENTITY molecules|appos|10058-F4 bind|nsubj|molecules bind|xcomp|END_ENTITY	We have identified the binding sites and determined the structural means by which two unrelated small molecules , 10058-F4 and 10074-G5 , bind c-Myc and stabilize the ID monomer over the highly ordered c-Myc-Max heterodimer .
19432426	4	10074-G5	570,578	c-Myc	626,631	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	10058-F4|conj|START_ENTITY inhibitors|appos|10058-F4 bound|nsubj|inhibitors bound|nmod|regions regions|nmod|domain domain|amod|END_ENTITY	Previously we showed that two c-Myc-Max inhibitors , 10058-F4 and 10074-G5 , bound to distinct ID regions of the monomeric c-Myc bHLHZip domain .
20801893	11	10074-G5	1792,1800	c-Myc	1898,1903	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	metabolites|nummod|START_ENTITY identification|nmod|metabolites help|nsubj|identification help|xcomp|design design|dobj|inhibitors inhibitors|nmod|END_ENTITY	Our identification of 10074-G5 metabolites in mice will help design new , more metabolically stable small-molecule inhibitors of c-Myc .
20801893	3	10074-G5	510,518	c-Myc	565,570	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	activity|appos|START_ENTITY activity|amod|binds binds|xcomp|and and|ccomp|distorts distorts|dobj|domain domain|nmod|END_ENTITY	The small molecule 7-nitro-N - -LRB- 2-phenylphenyl -RRB- -2,1,3 - benzoxadiazol-4-amine -LRB- 10074-G5 -RRB- binds to and distorts the bHLH-ZIP domain of c-Myc , thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity .
21933022	8	10074-G5	1266,1274	c-Myc	1328,1333	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	treated|nmod|START_ENTITY cells|acl|treated experiment|conj|cells displayed|nmod|experiment displayed|nmod|suggestive suggestive|compound|pERK pERK|conj|END_ENTITY	In another experiment , U251 and 5310 cells treated with 10074-G5 , c-Myc/Max inhibitor displayed reduction in pERK and c-Myc levels suggestive of a positive feedback loop between ERK/c-Myc/Max molecules .
23177256	0	10074-G5	48,56	c-Myc	32,37	10074-G5	c-Myc	MESH:C534883	4609	Chemical	Gene	START_ENTITY|amod|END_ENTITY	Pharmacophore identification of c-Myc inhibitor 10074-G5 .
26472107	12	10074-G5	1565,1573	c-MYC	1516,1521	10074-G5	c-MYC	MESH:C534883	4609	Chemical	Gene	10058-F4|conj|START_ENTITY END_ENTITY|dep|10058-F4	Molecular docking studies revealed that shikonin and its derivatives bind to the same DNA-binding domain of c-MYC as the known c-MYC inhibitors 10058-F4 and 10074-G5 .
26472107	12	10074-G5	1565,1573	c-MYC	1535,1540	10074-G5	c-MYC	MESH:C534883	4609	Chemical	Gene	10058-F4|conj|START_ENTITY c-MYC|dep|10058-F4 c-MYC|nmod|inhibitors inhibitors|amod|END_ENTITY	Molecular docking studies revealed that shikonin and its derivatives bind to the same DNA-binding domain of c-MYC as the known c-MYC inhibitors 10058-F4 and 10074-G5 .
21933022	8	10074-G5	1266,1274	pERK	1319,1323	10074-G5	pERK	MESH:C534883	9451	Chemical	Gene	treated|nmod|START_ENTITY cells|acl|treated experiment|conj|cells displayed|nmod|experiment displayed|nmod|suggestive suggestive|compound|END_ENTITY	In another experiment , U251 and 5310 cells treated with 10074-G5 , c-Myc/Max inhibitor displayed reduction in pERK and c-Myc levels suggestive of a positive feedback loop between ERK/c-Myc/Max molecules .
11485546	1	1008-1010	286,295	epidermal_growth_factor_receptor	208,240	1008-1010	epidermal growth factor receptor	MESH:C572335	1956	Chemical	Gene	Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- expression|nmod|Kurten Kurten|compound|END_ENTITY	Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- .
11485546	1	1008-1010	286,295	SNX1	91,95	1008-1010	SNX1	MESH:C572335	6642	Chemical	Gene	Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- regulate|dobj|expression regulate|nsubj|Sorting_nexin_1 Sorting_nexin_1|appos|END_ENTITY	Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- .
11485546	1	1008-1010	286,295	Sorting_nexin_1	74,89	1008-1010	Sorting nexin 1	MESH:C572335	6642	Chemical	Gene	Science|nummod|START_ENTITY -RSB-|dep|Science expression|amod|-RSB- regulate|dobj|expression regulate|nsubj|END_ENTITY	Sorting_nexin_1 -LRB- SNX1 -RRB- , a peripheral membrane protein , has previously been shown to regulate the cell-surface expression of the human epidermal_growth_factor_receptor -LSB- Kurten , Cadena and Gill -LRB- 1996 -RRB- Science 272 , 1008-1010 -RSB- .
18398080	8	101-106	1509,1516	LDL-C	1456,1461	101-106	LDL-C	MESH:C588327	22796	Chemical	Gene	104|appos|START_ENTITY 72|conj|104 72|nsubj|levels levels|nmod|END_ENTITY	Mean -LRB- 95 % confidence interval -RRB- levels for LDL-C in the last 12 months were 72 -LRB- 69-75 -RRB- and 104 -LRB- 101-106 -RRB- mg/dL and SBP levels were 117 -LRB- 115-118 -RRB- and 129 -LRB- 128-130 -RRB- mm Hg in the aggressive vs standard groups , respectively .
14610073	6	10-11-amino_acid	1095,1111	perilipin_A	1284,1295	10-11-amino acid	perilipin A	MESH:D000596	103968(Tax:10090)	Chemical	Gene	sequences|amod|START_ENTITY amino_acids|nmod|sequences sequence|nmod|amino_acids predicted|nsubj|sequence predicted|conj|critical critical|nsubj|terminus terminus|nmod|amino_acids amino_acids|acl:relcl|unique unique|nmod|END_ENTITY	The amino-terminal sequence between amino_acids 122 and 222 , including four 10-11-amino_acid sequences predicted to form amphipathic beta-strands and a consensus site for cAMP-dependent protein kinase , and the carboxyl terminus of 112 amino_acids that is unique to perilipin_A were critical to facilitate triacylglycerol storage .
8272570	4	10,11-dehydro-2-acetoxytrimipramine	528,563	C10	516,519	10,11-dehydro-2-acetoxytrimipramine	C10	MESH:C085056	3226	Chemical	Gene	give|xcomp|START_ENTITY resulted|xcomp|give resulted|nmod|END_ENTITY	Acetylation of the new metabolite resulted in dehydration at C10 to give 10,11-dehydro-2-acetoxytrimipramine .
19107468	6	10,11-didehydro	1493,1508	SCX	1435,1438	10,11-didehydro	SCX	null	642658	Chemical	Gene	C9-epi|conj|START_ENTITY derivatives|amod|C9-epi separation|nmod|derivatives allowed|dobj|separation allowed|nsubj|materials materials|compound|END_ENTITY	Furthermore , both SCX materials allowed successful separation of C9-epi and 10,11-didehydro derivatives from their respective educts in an application in synthetic Cinchona alkaloid chemistry .
20113739	2	10,11-dihydro-10-hydroxycarbamazepine	442,479	C18	617,620	10,11-dihydro-10-hydroxycarbamazepine	C18	MESH:C039775	27241	Chemical	Gene	Oxcarbazepine|dep|START_ENTITY baseline|nsubj|Oxcarbazepine baseline|acl|separated separated|nmod|min min|nmod|column column|compound|END_ENTITY	Oxcarbazepine and its metabolites -LRB- 10,11-dihydro-10-hydroxycarbamazepine , trans-10 ,11 - dihydro-10 ,11 - dihydroxycarbamazepine and 3-hydroxycarbamazepine -RRB- were baseline separated within 6.5 min on a reversed-phase C18 column with a phosphate buffer-acetonitrile-triethylamine mixture as the mobile phase .
2002449	2	10,11-dihydroxyaporphine	522,546	COMT	462,466	10,11-dihydroxyaporphine	COMT	CHEBI:48538	1312	Chemical	Gene	apomorphine|dep|START_ENTITY converted|nsubjpass|apomorphine conditions|acl:relcl|converted using|dobj|conditions END_ENTITY|acl|using	In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine -LRB- 10,11-dihydroxyaporphine -RRB- is converted in high yield into its 10-methyl_ether , apocodeine .
8010982	1	10,11-epoxide	67,80	CYP2C8	57,63	10,11-epoxide	CYP2C8	null	1558	Chemical	Gene	formation|amod|START_ENTITY Role|nmod|formation Role|nmod|CYP3A4 CYP3A4|conj|END_ENTITY	Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation .
22137858	0	10,11-epoxide	97,110	CYP3A1/2	170,178	10,11-epoxide	CYP3A1/2	null	25642;266682	Chemical	Gene	metabolite|amod|START_ENTITY pharmacokinetics|conj|metabolite hyperlipidemia|nmod|pharmacokinetics Effects|nmod|hyperlipidemia Effects|dep|Impact Impact|nmod|expression expression|nmod|END_ENTITY	Effects of poloxamer_407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats : Impact of decreased expression of both CYP3A1/2 and microsomal_epoxide_hydrolase .
25545162	3	10,11-epoxide	719,732	CYP3A4	548,554	10,11-epoxide	CYP3A4	null	1576	Chemical	Gene	product|amod|START_ENTITY CBZ|nmod|product turnover|nmod|CBZ leading|nmod|turnover engineered|xcomp|leading engineered|xcomp|mutants mutants|nsubj|END_ENTITY	On the basis of these simulations , we engineered CYP3A4 mutants I369F , I369L , A370V , and A370L , in which the productive binding orientation was expected to be stabilized , thus leading to increased turnover of CBZ to the 10,11-epoxide product .
8010982	1	10,11-epoxide	67,80	CYP3A4	46,52	10,11-epoxide	CYP3A4	null	1576	Chemical	Gene	formation|amod|START_ENTITY Role|nmod|formation Role|nmod|END_ENTITY	Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation .
8010982	5	10,11-epoxide	1234,1247	CYP3A4	1198,1204	10,11-epoxide	CYP3A4	null	1576	Chemical	Gene	formation|amod|START_ENTITY catalyst|nmod|formation catalyst|nsubj|END_ENTITY	These findings indicate that CYP3A4 is the principal catalyst of 10,11-epoxide formation in human liver .
22137858	0	10,11-epoxide	97,110	microsomal_epoxide_hydrolase	183,211	10,11-epoxide	microsomal epoxide hydrolase	null	25315(Tax:10116)	Chemical	Gene	metabolite|amod|START_ENTITY pharmacokinetics|conj|metabolite hyperlipidemia|nmod|pharmacokinetics Effects|nmod|hyperlipidemia Effects|dep|Impact Impact|nmod|expression expression|nmod|CYP3A1/2 CYP3A1/2|conj|END_ENTITY	Effects of poloxamer_407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats : Impact of decreased expression of both CYP3A1/2 and microsomal_epoxide_hydrolase .
7664272	3	10,11-methylenedioxy-camptothecin	722,755	CPT-11	597,603	10,11-methylenedioxy-camptothecin	CPT-11	MESH:C120496	963084(Tax:115711)	Chemical	Gene	camptothecin|conj|START_ENTITY cross-resistant|nmod|camptothecin report|conj|cross-resistant report|ccomp|cross-resistant cross-resistant|nmod|topotecan topotecan|conj|END_ENTITY	We now report that this cell line is highly cross-resistant to the camptothecin analogues topotecan -LRB- 180-fold -RRB- , 9-aminocamptothecin -LRB- 120-fold -RRB- , CPT-11 -LRB- 56-fold -RRB- , and SN38 -LRB- 101-fold -RRB- , but is only mildly cross-resistant to the parent compound camptothecin -LRB- 3.2-fold -RRB- and 10,11-methylenedioxy-camptothecin -LRB- 2.9-fold -RRB- .
11052623	2	10,11-methylenedioxy-CPT	1466,1490	CPT-11	1398,1404	10,11-methylenedioxy-CPT	CPT-11	null	963084(Tax:115711)	Chemical	Gene	that|conj|START_ENTITY that|nsubj|activity activity|nmod|SN-38 SN-38|dep|metabolite metabolite|nmod|END_ENTITY	Antiproliferative activity of SN-38 -LRB- the active metabolite of CPT-11 -RRB- , and TPT was compared to that of CPT and two CPT analogues , 10,11-methylenedioxy-CPT -LRB- MDC -RRB- , and the alkylating derivative , 7-chloromethyl-10 ,11 - MDC -LRB- CMMDC -RRB- .
16787918	6	1012-1212	1067,1076	Pax3	1093,1097	1012-1212	Pax3	MESH:C105975	18505(Tax:10090)	Chemical	Gene	bind|nummod|START_ENTITY bp|conj|bind elements|nmod|bp acetylated|nsubj|elements acetylated|dobj|END_ENTITY	Additionally , by using a combination of co-immunoprecipitation and chromatin immunoprecipitation , we show that the TGFbeta2 cis-regulatory elements between bp 741-940 and bp 1012-1212 bind acetylated Pax3 and are associated with p300/CBP and histone deacetylases .
16787918	6	1012-1212	1067,1076	TGFbeta2	1008,1016	1012-1212	TGFbeta2	MESH:C105975	21808(Tax:10090)	Chemical	Gene	bind|nummod|START_ENTITY bp|conj|bind elements|nmod|bp elements|amod|END_ENTITY	Additionally , by using a combination of co-immunoprecipitation and chromatin immunoprecipitation , we show that the TGFbeta2 cis-regulatory elements between bp 741-940 and bp 1012-1212 bind acetylated Pax3 and are associated with p300/CBP and histone deacetylases .
28792212	2	10-12-amino_acid	314,330	LC8	278,281	10-12-amino acid	LC8	null	8655	Chemical	Gene	sequence|amod|START_ENTITY is|nmod|sequence is|ccomp|is END_ENTITY|acl:relcl|is	A common feature among the more than 100 essential LC8 binding proteins is that in the 10-12-amino_acid recognition sequence there is a conserved QT motif but variable amino_acids N - and C-terminal to the QT_pair .
11435430	2	10-12-amino_acid	321,337	PC1	269,272	10-12-amino acid	PC1	null	5122	Chemical	Gene	segment|amod|START_ENTITY confined|nmod|segment confined|nsubjpass|sequence sequence|compound|END_ENTITY	The PC1 inhibitory sequence is mostly confined within a 10-12-amino_acid segment near the C terminus of the conserved human proSAAS and contains the critical KR -LRB- 244 -RRB- dibasic motif .
11435430	2	10-12-amino_acid	321,337	proSAAS	389,396	10-12-amino acid	proSAAS	null	27344	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|terminus terminus|nmod|END_ENTITY	The PC1 inhibitory sequence is mostly confined within a 10-12-amino_acid segment near the C terminus of the conserved human proSAAS and contains the critical KR -LRB- 244 -RRB- dibasic motif .
10358058	1	1012-amino_acid_polypeptide_cPLA2-beta	98,136	cPLA2-alpha	173,184	1012-amino acid polypeptide cPLA2-beta	cPLA2-alpha	MESH:C105975	5321	Chemical	Gene	START_ENTITY|acl:relcl|has has|nmod|domain domain|amod|END_ENTITY	We have isolated a cDNA encoding a 1012-amino_acid_polypeptide_cPLA2-beta , that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain .
7981215	1	10-12_amino_acids	110,127	rhodopsin	227,236	10-12 amino acids	rhodopsin	null	6010	Chemical	Gene	Peptides|nmod|START_ENTITY Peptides|acl:relcl|overlapped overlapped|nmod|tail tail|nmod|END_ENTITY	Peptides of 10-12_amino_acids in length , which overlapped with the sequence of the last 20 amino_acids in the C-terminal tail of rhodopsin , were synthesized and used as substrates for rhodopsin_kinase .
7981215	1	10-12_amino_acids	110,127	rhodopsin_kinase	282,298	10-12 amino acids	rhodopsin kinase	null	131890	Chemical	Gene	Peptides|nmod|START_ENTITY synthesized|nsubjpass|Peptides synthesized|nmod|substrates substrates|nmod|END_ENTITY	Peptides of 10-12_amino_acids in length , which overlapped with the sequence of the last 20 amino_acids in the C-terminal tail of rhodopsin , were synthesized and used as substrates for rhodopsin_kinase .
3335854	10	1012S-Sepharose	1538,1553	P36	1531,1534	1012S-Sepharose	P36	MESH:C060004	406192(Tax:9823)	Chemical	Gene	concentrations|amod|START_ENTITY inhibit|nmod|concentrations inhibit|dobj|binding binding|nmod|END_ENTITY	However , the ability of the gamma-aminobutyrate/benzodiazepine receptor inverse agonists , methyl - and ethyl-beta-carboline-3-carboxylate , to inhibit the binding of P36 to 1012S-Sepharose at relatively low concentrations indicates that P36 exhibits a degree of binding specificity .
3335854	10	1012S-Sepharose	1538,1553	P36	1602,1605	1012S-Sepharose	P36	MESH:C060004	406192(Tax:9823)	Chemical	Gene	concentrations|amod|START_ENTITY inhibit|nmod|concentrations receptor|acl|inhibit ability|nmod|receptor indicates|nsubj|ability indicates|ccomp|exhibits exhibits|nsubj|END_ENTITY	However , the ability of the gamma-aminobutyrate/benzodiazepine receptor inverse agonists , methyl - and ethyl-beta-carboline-3-carboxylate , to inhibit the binding of P36 to 1012S-Sepharose at relatively low concentrations indicates that P36 exhibits a degree of binding specificity .
3335854	1	1012S-Sepharose	168,183	P36	250,253	1012S-Sepharose	P36	MESH:C060004	406192(Tax:9823)	Chemical	Gene	column|nmod|START_ENTITY chromatography|nmod|column resulted|nsubj|chromatography resulted|nmod|detection detection|nmod|protein protein|appos|END_ENTITY	Benzodiazepine-affinity chromatography , on a column of 1012S-Sepharose , resulted in the detection and purification of a binding protein -LRB- P36 -RRB- from the cytosolic fraction of pig cerebral cortex .
17709415	2	1,014-amino-acid	271,287	Cdc42	371,376	1,014-amino-acid	Cdc42	null	998	Chemical	Gene	toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|RhoA RhoA|conj|END_ENTITY	These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain .
17709415	2	1,014-amino-acid	271,287	Rac1	361,365	1,014-amino-acid	Rac1	null	5879	Chemical	Gene	toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|RhoA RhoA|conj|END_ENTITY	These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain .
17709415	2	1,014-amino-acid	271,287	RhoA	355,359	1,014-amino-acid	RhoA	null	387	Chemical	Gene	toxins|amod|START_ENTITY catalyze|nsubj|toxins catalyze|dobj|deamidation deamidation|nmod|residue residue|nmod|END_ENTITY	These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA , Rac1 , and Cdc42 and consist of a putative N-terminal binding domain , a transmembrane region , and a C-terminal catalytic domain .
22070231	12	1014C	1556,1561	L1014	1436,1441	1014C	L1014	null	1114359(Tax:272623)	Chemical	Gene	substitution|nummod|START_ENTITY resulting|nmod|substitution mutation|acl|resulting identified|nmod|mutation identified|nsubjpass|mutations mutations|nmod|codon codon|compound|END_ENTITY	Two alternative mutations within the L1014 codon were identified in Culex_pipiens molestus Forskal , 1775 , including a non-synonymous mutation resulting in a 1014C substitution .
9724739	6	101-5-8	979,986	p53	1003,1006	101-5-8	p53	MESH:C000591311	7157	Chemical	Gene	mutations|appos|START_ENTITY mutations|conj|deletion deletion|dep|END_ENTITY	Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression .
9724739	6	101-5-8	979,986	p53	1026,1029	101-5-8	p53	MESH:C000591311	7157	Chemical	Gene	mutations|appos|START_ENTITY mutations|conj|deletion deletion|dep|forms forms|nmod|END_ENTITY	Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression .
9724739	6	101-5-8	979,986	p53	1067,1070	101-5-8	p53	MESH:C000591311	7157	Chemical	Gene	mutations|appos|START_ENTITY exhibit|nsubj|mutations exhibit|dobj|increase increase|nmod|levels levels|compound|END_ENTITY	Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression .
9724739	6	101-5-8	979,986	p53	975,978	101-5-8	p53	MESH:C000591311	7157	Chemical	Gene	mutations|appos|START_ENTITY mutations|dep|END_ENTITY	Respective mutations -LRB- p53 -LRB- 101-5-8 -RRB- -RRB- and deletion -LRB- p53 -LRB- Deltap7 -RRB- -RRB- forms of p53 did not exhibit the same increase in p53 levels upon DeltaMEKK1 expression .
11960002	6	1015C	846,851	gata1	834,839	1015C	gata1	null	30481(Tax:7955)	Chemical	Gene	_|nummod|START_ENTITY gene|appos|_ gene|amod|END_ENTITY	Through positional and candidate gene cloning approaches we identified a nonsense mutation in the gata1 gene , 1015C _ -- > _ T -LRB- Arg-339 _ -- > _ Stop -RRB- , in vlt -LRB- m651 -RRB- .
21699628	8	10-15_U	1114,1121	FXI	1009,1012	10-15 U	FXI	null	2160	Chemical	Gene	administration|nmod|START_ENTITY peri|dep|administration application|dep|peri application|dep|inhibitor inhibitor|conj|END_ENTITY	The application required an investigator-initiated IRB-approved protocol for treatment and safety/efficacy monitoring that included : preoperative thrombophilia , FXI inhibitor and pharmacokinetic -LRB- PK -RRB- evaluations ; peri - postoperative administration of < = 4 doses of 10-15_U / kg Hemoleven ; DIC monitoring ; postoperative thromboprophylaxis ; observation for product efficacy and potential complications .
12172218	3	10-16-10-8_mol	594,608	angiotensin_II	502,516	10-16-10-8 mol	angiotensin II	MESH:C020748	183	Chemical	Gene	NA|dep|START_ENTITY noradrenaline|appos|NA endothelin-1|conj|noradrenaline endothelin-1|conj|END_ENTITY	We assessed the effects of endothelin-1 -LRB- ET-1 -RRB- , angiotensin_II -LRB- AT -RRB- , endothelin-antagonists -LRB- BQ-123 and BQ-788 -RRB- and noradrenaline -LRB- NA , each 10-16-10-8_mol -RRB- on vasoconstriction in the human skin microcirculation in vivo in 25 healthy male volunteers -LRB- 13 with CC genotype , 12 TC/TT genotype -RRB- using laser Doppler flowmetry .
12172218	3	10-16-10-8_mol	594,608	endothelin-1	481,493	10-16-10-8 mol	endothelin-1	MESH:C020748	1906	Chemical	Gene	NA|dep|START_ENTITY noradrenaline|appos|NA END_ENTITY|conj|noradrenaline	We assessed the effects of endothelin-1 -LRB- ET-1 -RRB- , angiotensin_II -LRB- AT -RRB- , endothelin-antagonists -LRB- BQ-123 and BQ-788 -RRB- and noradrenaline -LRB- NA , each 10-16-10-8_mol -RRB- on vasoconstriction in the human skin microcirculation in vivo in 25 healthy male volunteers -LRB- 13 with CC genotype , 12 TC/TT genotype -RRB- using laser Doppler flowmetry .
8554512	2	10-16_carbon	437,449	albumin	325,332	10-16 carbon	albumin	null	213	Chemical	Gene	atoms|amod|START_ENTITY containing|dobj|atoms engineered|xcomp|containing engineered|nsubjpass|Insulins Insulins|nmod|affinity affinity|nmod|END_ENTITY	Insulins with affinity for albumin were engineered by acylation of the epsilon-amino group of LysB29 with saturated fatty_acids containing 10-16_carbon atoms .
19959665	9	10,16-dihydroxypalmitate	1461,1485	CYP77A6	1291,1298	10,16-dihydroxypalmitate	CYP77A6	null	820222(Tax:3702)	Chemical	Gene	synthesis|nmod|START_ENTITY CYP86A4|nmod|synthesis acting|nmod|CYP86A4 hydroxylase|acl|acting provided|ccomp|hydroxylase provided|nsubj|Comparison Comparison|nmod|profiles profiles|nmod|knockouts knockouts|nmod|END_ENTITY	Comparison of cutin monomer profiles in knockouts for CYP77A6 and the fatty_acid omega-hydroxylase CYP86A4 provided genetic evidence that CYP77A6 is an in-chain hydroxylase acting subsequently to CYP86A4 in the synthesis of 10,16-dihydroxypalmitate .
19959665	9	10,16-dihydroxypalmitate	1461,1485	CYP77A6	1375,1382	10,16-dihydroxypalmitate	CYP77A6	null	820222(Tax:3702)	Chemical	Gene	synthesis|nmod|START_ENTITY CYP86A4|nmod|synthesis acting|nmod|CYP86A4 hydroxylase|acl|acting hydroxylase|nsubj|END_ENTITY	Comparison of cutin monomer profiles in knockouts for CYP77A6 and the fatty_acid omega-hydroxylase CYP86A4 provided genetic evidence that CYP77A6 is an in-chain hydroxylase acting subsequently to CYP86A4 in the synthesis of 10,16-dihydroxypalmitate .
21628525	3	10,16-dihydroxypalmitate	592,616	pec1	514,518	10,16-dihydroxypalmitate	pec1	null	817232(Tax:3702)	Chemical	Gene	fatty_acids|conj|START_ENTITY monomers|nmod|fatty_acids reduced|nsubjpass|monomers reduced|nmod|flowers flowers|amod|END_ENTITY	In pec1 flowers , typical cutin monomers , such as - hydroxylated fatty_acids and 10,16-dihydroxypalmitate , are reduced to 40 % of wild-type levels and are accompanied by the appearance of lipidic inclusions within the epidermal cell .
10878014	5	1017-1237	692,701	Hklp2	636,641	1017-1237	Hklp2	MESH:C488695	56992	Chemical	Gene	residues|nummod|START_ENTITY comprised|dobj|residues mapped|dep|comprised mapped|nsubjpass|domain domain|nmod|END_ENTITY	The interaction domain of Hklp2 was mapped to the portion that comprised residues 1017-1237 and that was phosphorylated in vitro by incubating with mitotic but not interphasic HeLa cell extracts .
15770500	2	10171A	368,374	perilipin	330,339	10171A	perilipin	MESH:D015283	5346	Chemical	Gene	T|nummod|START_ENTITY T|conj|T locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
15770500	2	10171A	368,374	PLIN	341,345	10171A	PLIN	MESH:D015283	5346	Chemical	Gene	T|nummod|START_ENTITY T|conj|T locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|perilipin perilipin|appos|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
15770500	2	10171A	368,374	PLIN	354,358	10171A	PLIN	MESH:D015283	5346	Chemical	Gene	T|nummod|START_ENTITY T|conj|T T|compound|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
19542440	4	1017-DRAK2	1074,1084	DRAK2	1037,1042	1017-DRAK2	DRAK2	MESH:C488695	98267(Tax:10090)	Chemical	Gene	mice|nummod|START_ENTITY ectopically|appos|mice ectopically|acl|expressing expressing|dobj|END_ENTITY	To further evaluate the differential role of DRAK2 in central vs peripheral tolerance and to assess its impact on the development of autoimmune_diseases , we have generated a transgenic -LRB- Tg -RRB- mouse_strain ectopically expressing DRAK2 via the lck proximal promoter -LRB- 1017-DRAK2 Tg mice -RRB- .
19542440	4	1017-DRAK2	1074,1084	DRAK2	856,861	1017-DRAK2	DRAK2	MESH:C488695	98267(Tax:10090)	Chemical	Gene	mice|nummod|START_ENTITY ectopically|appos|mice generated|dobj|ectopically generated|ccomp|evaluate evaluate|dobj|role role|nmod|END_ENTITY	To further evaluate the differential role of DRAK2 in central vs peripheral tolerance and to assess its impact on the development of autoimmune_diseases , we have generated a transgenic -LRB- Tg -RRB- mouse_strain ectopically expressing DRAK2 via the lck proximal promoter -LRB- 1017-DRAK2 Tg mice -RRB- .
27033423	6	10,17S-DHDHA	1047,1059	PD1	1002,1005	10,17S-DHDHA	PD1	null	6139	Chemical	Gene	acid|appos|START_ENTITY D1|appos|acid D1|appos|END_ENTITY	Other SPM included protectin D1 -LRB- PD1 -RRB- , 10S,17S-dihydroxydocosahexaenoic _ acid -LRB- 10,17S-DHDHA -RRB- , maresin-1 -LRB- MaR-1 -RRB- and 14-hydroxydocosahexaenoic_acid -LRB- 14-HDHA -RRB- derived from docosahexaenoic_acid -LRB- DHA -RRB- .
15744015	1	10-17_selenocysteines	217,238	Selenoprotein_P	57,72	10-17 selenocysteines	Selenoprotein P	null	20363(Tax:10090)	Chemical	Gene	contains|xcomp|START_ENTITY member|acl:relcl|contains member|nsubj|END_ENTITY	Selenoprotein_P -LRB- SEPP1 -RRB- , an extracellular glycoprotein of unknown function , is a unique member of the selenoprotein family that , depending on species , contains 10-17_selenocysteines in its primary structure ; in contrast , all other family members contain a single selenocysteine residue .
15744015	1	10-17_selenocysteines	217,238	SEPP1	74,79	10-17 selenocysteines	SEPP1	null	20363(Tax:10090)	Chemical	Gene	contains|xcomp|START_ENTITY member|acl:relcl|contains member|nsubj|Selenoprotein_P Selenoprotein_P|appos|END_ENTITY	Selenoprotein_P -LRB- SEPP1 -RRB- , an extracellular glycoprotein of unknown function , is a unique member of the selenoprotein family that , depending on species , contains 10-17_selenocysteines in its primary structure ; in contrast , all other family members contain a single selenocysteine residue .
26019148	3	10-18_carbons	504,517	FAA1	531,535	10-18 carbons	FAA1	null	854495(Tax:4932)	Chemical	Gene	n-alkanes|nmod|START_ENTITY decreased|nmod|n-alkanes decreased|advcl|showed showed|nsubj|mutant mutant|compound|END_ENTITY	The FAT1 deletion mutant exhibited decreased growth on n-alkanes of 10-18_carbons , whereas the FAA1 mutant showed growth reduction on n-alkane_of_16_carbons .
26019148	3	10-18_carbons	504,517	FAT1	440,444	10-18 carbons	FAT1	null	852329(Tax:4932)	Chemical	Gene	n-alkanes|nmod|START_ENTITY decreased|nmod|n-alkanes decreased|nsubj|exhibited exhibited|compound|END_ENTITY	The FAT1 deletion mutant exhibited decreased growth on n-alkanes of 10-18_carbons , whereas the FAA1 mutant showed growth reduction on n-alkane_of_16_carbons .
7417479	1	10-18_carbons	147,160	serum_albumin	218,231	10-18 carbons	serum albumin	null	213	Chemical	Gene	START_ENTITY|conj|END_ENTITY	The binding of lysophosphatidylcholines containing 10-18_carbons and , with 18 carbon series , up to three double bonds , to serum_albumin was studied by heat-burst microcalorimetry .
19041090	4	101_PCB	719,726	PCB	686,689	101 PCB	PCB	MESH:C009828	5091	Chemical	Gene	congeners|nummod|START_ENTITY estimated|nmod|congeners estimated|nsubjpass|burden burden|compound|END_ENTITY	PCB body burden was estimated by 101_PCB congeners and neuropsychological functioning was assessed by a battery of 18 tests .
18654638	10	10-20_amino_acids	1537,1554	GAP-43	1518,1524	10-20 amino acids	GAP-43	null	2596	Chemical	Gene	containing|xcomp|START_ENTITY fragments|acl|containing fragments|nmod|END_ENTITY	N-terminal fragments of GAP-43 , containing 10-20_amino_acids , will activate heterotrimeric G proteins , direct GAP-43 to the membrane and lipid rafts , and cause the formation of filopodia , possibly by causing a change in membrane tension .
18654638	10	10-20_amino_acids	1537,1554	GAP-43	1604,1610	10-20 amino acids	GAP-43	null	2596	Chemical	Gene	containing|xcomp|START_ENTITY fragments|acl|containing activate|nsubj|fragments activate|conj|direct direct|dobj|END_ENTITY	N-terminal fragments of GAP-43 , containing 10-20_amino_acids , will activate heterotrimeric G proteins , direct GAP-43 to the membrane and lipid rafts , and cause the formation of filopodia , possibly by causing a change in membrane tension .
17570371	5	1021-1652	854,863	OPG	697,700	1021-1652	OPG	MESH:C036666	4982	Chemical	Gene	pg/mL|appos|START_ENTITY patients|dep|pg/mL higher|nmod|patients higher|nsubj|concentrations concentrations|compound|END_ENTITY	OPG concentrations were higher in patients with long-standing RA -LRB- n = 67 -RRB- -LSB- median -LRB- interquartile range -RRB- -RSB- : -LSB- 1895 -LRB- 1337-2847 -RRB- pg/mL , and early RA -LRB- n = 90 -RRB- : -LSB- 1340 -LRB- 1021-1652 -RRB- pg/mL , than controls 1068 -LRB- 692-1434 -RRB- pg/mL ; -LRB- p < 0.001 -RRB- -RSB- .
16169633	7	10-23U	839,845	DPP_IV	828,834	10-23U	DPP IV	null	1803	Chemical	Gene	l|nummod|START_ENTITY l|nsubj|range range|nmod|END_ENTITY	RESULTS : The reference range for DPP_IV was 10-23U / l -LRB- mean : 16.01 + / -3.2 -RRB- .
2656259	1	1024-amino-acid	215,230	HlyA	250,254	1024-amino-acid	HlyA	null	7701379(Tax:562)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	We have studied the C-terminal signal which directs the complete export of the 1024-amino-acid hemolysin protein -LRB- HlyA -RRB- of Escherichia_coli across both bacterial membranes into the surrounding medium .
10423761	2	102_67Ga-citrate	350,366	SCC	433,436	102 67Ga-citrate	SCC	MESH:C103850	6317	Chemical	Gene	scans|amod|START_ENTITY performed|nsubjpass|scans performed|nmod|patients patients|nmod|END_ENTITY	Altogether , 102_67Ga-citrate whole-body scans were performed on 83 patients with head and neck SCC using a dual-headed gamma camera .
11127865	8	1026G	893,898	FXI	870,873	1026G	FXI	MESH:C036630	2160	Chemical	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The FXI splicing mutation , 1026G -- > T cd 324 , was found in compound heterozygosity with missense mutation FXI_K518N .
2136995	1	1031-1040	160,169	5-HT1A	193,199	1031-1040	5-HT1A	MESH:C056494	24473(Tax:10116)	Chemical	Gene	Neurochem|nummod|START_ENTITY Mestikawy|nmod|Neurochem investigations|dep|Mestikawy shown|nsubj|investigations shown|ccomp|modulated modulated|nsubjpass|sites sites|nummod|END_ENTITY	Previous investigations -LRB- El Mestikawy et al. , J Neurochem 51 : 1031-1040 , 1988 -RRB- have shown that 5-HT1A binding sites -LRB- R -LSB- 5-HT1A -RSB- -RRB- solubilized by CHAPS from rat hippocampal membranes can be modulated by guanine_nucleotides , as expected from their solubilization together with associated G regulatory proteins -LRB- G -RRB- .
2136995	1	1031-1040	160,169	5-HT1A	217,223	1031-1040	5-HT1A	MESH:C056494	24473(Tax:10116)	Chemical	Gene	Neurochem|nummod|START_ENTITY Mestikawy|nmod|Neurochem investigations|dep|Mestikawy shown|nsubj|investigations shown|ccomp|modulated modulated|nsubjpass|sites sites|appos|-RSB- -RSB-|compound|END_ENTITY	Previous investigations -LRB- El Mestikawy et al. , J Neurochem 51 : 1031-1040 , 1988 -RRB- have shown that 5-HT1A binding sites -LRB- R -LSB- 5-HT1A -RSB- -RRB- solubilized by CHAPS from rat hippocampal membranes can be modulated by guanine_nucleotides , as expected from their solubilization together with associated G regulatory proteins -LRB- G -RRB- .
12616822	8	103-232	1391,1398	CRP	1234,1237	103-232	CRP	MESH:C016822	1401	Chemical	Gene	136|appos|START_ENTITY group|conj|136 found|nmod|group found|nsubjpass|levels levels|compound|END_ENTITY	Significantly lower CRP levels were found in the NAC group on day one and two -LSB- t24 : median : 84.5 interquartile range : -LRB- 62.48-120 .25 -RRB- vs. 118 -LRB- 86-137 -RRB- mg/l ; p = 0.020 ; t48 : 136 -LRB- 103-232 -RRB- vs. 195 -LRB- 154.5-252 -RRB- mg/l p = 0.013 , NAC vs. placebo -RSB- .
8961926	3	10325-10333	668,679	keratinocyte_growth_factor_receptor	444,479	10325-10333	keratinocyte growth factor receptor	MESH:C066072	2263	Chemical	Gene	Biochemistry|nummod|START_ENTITY -RSB-|dep|Biochemistry A.|amod|-RSB- Gray|appos|A. specificity|nmod|Gray determining|dobj|specificity participate|advcl|determining participate|nsubj|loop loop|nmod|domain domain|nmod|END_ENTITY	The F-G loop in the membrane proximal domain of the keratinocyte_growth_factor_receptor has previously been shown to participate in determining the FGF ligand binding specificity of KGFR -LSB- Gray , T. E. , Eisenstein , M. , Shimon , T. , Givol , D. , _ Yayon , A. -LRB- 1995 -RRB- Biochemistry 34 , 10325-10333 -RSB- .
8961926	3	10325-10333	668,679	KGFR	574,578	10325-10333	KGFR	MESH:C066072	2263	Chemical	Gene	Biochemistry|nummod|START_ENTITY -RSB-|dep|Biochemistry A.|amod|-RSB- Gray|appos|A. Gray|compound|END_ENTITY	The F-G loop in the membrane proximal domain of the keratinocyte_growth_factor_receptor has previously been shown to participate in determining the FGF ligand binding specificity of KGFR -LSB- Gray , T. E. , Eisenstein , M. , Shimon , T. , Givol , D. , _ Yayon , A. -LRB- 1995 -RRB- Biochemistry 34 , 10325-10333 -RSB- .
15450424	12	10347C	1698,1704	CYP2S1	1687,1693	10347C	CYP2S1	null	29785	Chemical	Gene	-LSB-|nummod|START_ENTITY *|dep|-LSB- *|compound|END_ENTITY	The respective allelic variants , CYP2S1 * 2 -LRB- -LSB- 10347C _ > _ T -RSB- -RRB- and CYP2S1 * 3 -LRB- 13106C _ > _ T ; 13255A _ > _ G -RSB- -RRB- , occurred in our study population at frequencies of 0.50 and 3.75 % , respectively .
15450424	12	10347C	1698,1704	CYP2S1	1715,1721	10347C	CYP2S1	null	29785	Chemical	Gene	-LSB-|nummod|START_ENTITY *|dep|-LSB- *|conj|3 3|compound|END_ENTITY	The respective allelic variants , CYP2S1 * 2 -LRB- -LSB- 10347C _ > _ T -RSB- -RRB- and CYP2S1 * 3 -LRB- 13106C _ > _ T ; 13255A _ > _ G -RSB- -RRB- , occurred in our study population at frequencies of 0.50 and 3.75 % , respectively .
1833637	4	1,035-amino-acid	686,702	CDC68	670,675	1,035-amino-acid	CDC68	null	852665(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|END_ENTITY	CDC68 encodes a 1,035-amino-acid protein with a highly acidic and serine-rich carboxyl terminus .
16214042	4	1035-amino_acid	404,419	USP31	436,441	1035-amino acid	USP31	MESH:C071737	57478	Chemical	Gene	isoform|amod|START_ENTITY isoform|nmod|END_ENTITY	One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- .
16214042	4	1035-amino_acid	404,419	USP31	443,448	1035-amino acid	USP31	MESH:C071737	57478	Chemical	Gene	isoform|amod|START_ENTITY isoform|nmod|USP31 END_ENTITY|appos|USP31	One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- .
16214042	4	1035-amino_acid	404,419	USP31S1	518,525	1035-amino acid	USP31S1	MESH:C071737	57478	Chemical	Gene	isoform|amod|START_ENTITY isoform|conj|other other|dep|isoform isoform|appos|END_ENTITY	One cDNA encodes a 1035-amino_acid long isoform of USP31 -LRB- USP31 , long isoform -RRB- and the other a 485-amino_acid long isoform of USP31 -LRB- USP31S1 , short isoform -RRB- .
12842213	5	1039G	607,612	OPA1	593,597	1039G	OPA1	null	4976	Chemical	Gene	_|nummod|START_ENTITY gene|dep|_ gene|compound|END_ENTITY	RESULTS : Of the 12 patients , 2 had nonsense mutations of the OPA1 gene -LRB- nt 1039G _ -- > _ T and nt 1096C _ -- > _ T , leading to Glu347Stop and Arg366Stop , respectively -RRB- .
9680353	10	103B2/9E10	2077,2087	CD164	2071,2076	103B2/9E10	CD164	MESH:D004958	8763	Chemical	Gene	analyses|appos|START_ENTITY analyses|nmod|END_ENTITY	Further analyses of the CD34 -LRB- lo / - -RRB- CD164 -LRB- 103B2/9E10 -RRB- + subsets indicated that one of the most prominent populations consists of maturing erythroid cells .
9680353	10	103B2/9E10	2077,2087	CD34	2061,2065	103B2/9E10	CD34	MESH:D004958	947	Chemical	Gene	analyses|appos|START_ENTITY analyses|nmod|CD164 CD164|compound|END_ENTITY	Further analyses of the CD34 -LRB- lo / - -RRB- CD164 -LRB- 103B2/9E10 -RRB- + subsets indicated that one of the most prominent populations consists of maturing erythroid cells .
12799135	5	103_polyglutamine	892,909	Htt	867,870	103 polyglutamine	Htt	MESH:C097188	3064	Chemical	Gene	repeat|amod|START_ENTITY 25|conj|repeat expressing|nmod|25 expressing|dobj|exon exon|nmod|protein protein|appos|END_ENTITY	To test this hypothesis , reporter gene assays were performed in inducible PC12 cell lines expressing exon 1 of the human huntingtin protein -LRB- Htt -RRB- with either a 25 or 103_polyglutamine -LRB- Q -RRB- repeat .
12799135	5	103_polyglutamine	892,909	huntingtin	847,857	103 polyglutamine	huntingtin	MESH:C097188	3064	Chemical	Gene	repeat|amod|START_ENTITY 25|conj|repeat expressing|nmod|25 expressing|dobj|exon exon|nmod|protein protein|compound|END_ENTITY	To test this hypothesis , reporter gene assays were performed in inducible PC12 cell lines expressing exon 1 of the human huntingtin protein -LRB- Htt -RRB- with either a 25 or 103_polyglutamine -LRB- Q -RRB- repeat .
1288510	1	10405-02-4	185,195	CAS	181,184	10405-02-4	CAS	MESH:C553544	9564	Chemical	Gene	END_ENTITY|nummod|START_ENTITY	In a randomized double-blind study the effects of increasing doses of trospium_chloride -LRB- Spasmo-lyt , CAS 10405-02-4 -RRB- , 0.2 , 0.5 , 1.0 , and 1.5 mg i.v. , on gall-bladder_contractility were compared among themselves and against placebo and n-butylscopolamine_bromide -LRB- 20 mg i.v. -RRB- by an intraindividual 5-fold crossover technique .
11280720	3	104-123	666,673	protein_kinase_C_delta	592,614	104-123	protein kinase C delta	MESH:C051848	5580	Chemical	Gene	sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|nmod|factor-I factor-I|acl|receptor-mediated receptor-mediated|xcomp|signaling signaling|advcl|vitro vitro|nmod|interaction interaction|nmod|END_ENTITY	Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL .
11280720	3	104-123	666,673	pVHL	467,471	104-123	pVHL	MESH:C051848	7428	Chemical	Gene	sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|dep|END_ENTITY	Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL .
11280720	3	104-123	666,673	pVHL	701,705	104-123	pVHL	MESH:C051848	7428	Chemical	Gene	sequence|appos|START_ENTITY sequence|nmod|beta-domain beta-domain|nmod|END_ENTITY	Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL .
11280720	4	104-123	754,761	pVHL	770,774	104-123	pVHL	MESH:C051848	7428	Chemical	Gene	sequence|appos|START_ENTITY sequence|nmod|END_ENTITY	In the present study , the amino_acid sequence -LRB- 104-123 -RRB- of the pVHL was conjugated to the protein transduction domain of HIV-TAT protein -LRB- TATFLAGVHL-peptide -RRB- to facilitate entry into cells , and we demonstrate that this amino_acid region of VHL is sufficient to block proliferation and invasion of 786-O renal cancer cells in vitro .
11280720	3	104-123	666,673	VHL	449,452	104-123	VHL	MESH:C051848	7428	Chemical	Gene	sequence|appos|START_ENTITY mediated|nmod|sequence inhibit|conj|mediated inhibit|nsubj|Reintroduction Reintroduction|nmod|product product|compound|END_ENTITY	Reintroduction of the VHL gene product -LRB- pVHL -RRB- can inhibit on insulin-like growth factor-I receptor-mediated signaling in RCC cells in vitro through interaction with protein_kinase_C_delta and is mediated by a specific amino_acid sequence -LRB- 104-123 -RRB- in the beta-domain of the pVHL .
11280720	4	104-123	754,761	VHL	947,950	104-123	VHL	MESH:C051848	7428	Chemical	Gene	sequence|appos|START_ENTITY conjugated|nsubjpass|sequence conjugated|conj|demonstrate demonstrate|ccomp|sufficient sufficient|nsubj|region region|nmod|END_ENTITY	In the present study , the amino_acid sequence -LRB- 104-123 -RRB- of the pVHL was conjugated to the protein transduction domain of HIV-TAT protein -LRB- TATFLAGVHL-peptide -RRB- to facilitate entry into cells , and we demonstrate that this amino_acid region of VHL is sufficient to block proliferation and invasion of 786-O renal cancer cells in vitro .
18950599	5	1042D	746,751	pfmdr1	732,738	1042D	pfmdr1	null	813045(Tax:36329)	Chemical	Gene	alleles|nummod|START_ENTITY 1042N|conj|alleles 1042N|amod|END_ENTITY	The pfmdr1 1042N , 1042D alleles and a mixture -LRB- 1042N +1042 D -RRB- of the alleles were found in 94 -LRB- 85.5 % -RRB- , 12 -LRB- 10.9 % -RRB- and 4 -LRB- 3.6 % -RRB- isolates , respectively .
1898367	4	1043-amino-acid	903,918	valyl-tRNA_synthetase	957,978	1043-amino-acid	valyl-tRNA synthetase	null	7407	Chemical	Gene	overlap|amod|START_ENTITY overlap|nmod|END_ENTITY	Comparison of the derived amino_acid sequence of the G7a protein with the National Biomedical Research Foundation protein databases revealed 42 % identity in a 250-amino-acid overlap with Bacillus_stearothermophilus valyl-tRNA_synthetase , 38.0 % identity in a 993-amino-acid overlap with Escherichia_coli valyl-tRNA_synthetase -LRB- val RS -RRB- , and 48.3 % identity in a 1043-amino-acid overlap with Saccharomyces_cerevisiae valyl-tRNA_synthetase .
26820066	10	1044-1051	1496,1505	CLUAP1	1408,1414	1044-1051	CLUAP1	MESH:C055611	23059	Chemical	Gene	report|dobj|START_ENTITY report|xcomp|linking linking|dobj|mutations mutations|nmod|END_ENTITY	This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate LCA gene.Genet Med 18 10 , 1044-1051 .
26820066	10	1044-1051	1496,1505	CLUAP1	1448,1454	1044-1051	CLUAP1	MESH:C055611	23059	Chemical	Gene	report|dobj|START_ENTITY report|conj|establishes establishes|dobj|END_ENTITY	This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate LCA gene.Genet Med 18 10 , 1044-1051 .
12186888	6	1,047-amino-acid	1106,1122	Ahi-1	1085,1090	1,047-amino-acid	Ahi-1	null	52906(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY	The Ahi-1 cDNA encodes a 1,047-amino-acid protein .
12869526	1	1047-amino_acid	230,245	GEMIN4	146,152	1047-amino acid	GEMIN4	MESH:C425326	50628	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|HCAP1 HCAP1|appos|variant variant|nmod|END_ENTITY	The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein .
12869526	1	1047-amino_acid	230,245	HCAP1	97,102	1047-amino acid	HCAP1	MESH:C425326	50628	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|END_ENTITY	The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein .
12869526	1	1047-amino_acid	230,245	HCC-associated_Protein_1	104,128	1047-amino acid	HCC-associated Protein 1	MESH:C425326	50628	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein mapped|conj|encodes mapped|nsubjpass|HCAP1 HCAP1|appos|END_ENTITY	The gene HCAP1 -LRB- HCC-associated_Protein_1 -RRB- , one variant of GEMIN4 , has been mapped in a minimum LOH region on chromosome 17p13 .3 and encodes a 1047-amino_acid protein .
15804288	3	1047-amino-acid	620,635	TLR7	600,604	1047-amino-acid	TLR7	null	418638(Tax:9031)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The chicken TLR7 gene encodes a 1047-amino-acid protein with 62 % identity to human TLR7 and a conserved pattern of predicted leucine-rich repeats .
15804288	3	1047-amino-acid	620,635	TLR7	671,675	1047-amino-acid	TLR7	null	51284	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nmod|identity identity|nmod|END_ENTITY	The chicken TLR7 gene encodes a 1047-amino-acid protein with 62 % identity to human TLR7 and a conserved pattern of predicted leucine-rich repeats .
9115249	6	104-amino_acid	841,855	phospholipase_A2	871,887	104-amino acid	phospholipase A2	MESH:C089163	406141(Tax:7460)	Chemical	Gene	residues|amod|START_ENTITY subunit|appos|residues consists|nmod|subunit consists|nmod|activity activity|amod|END_ENTITY	The IpTxi dimer consists of a large subunit -LRB- 104-amino_acid residues -RRB- with phospholipase_A2 -LRB- PLA2 -RRB- activity covalently linked by a disulfide bond to a smaller -LRB- 27 amino_acid residues -RRB- , structurally unrelated subunit .
9115249	6	104-amino_acid	841,855	PLA2	889,893	104-amino acid	PLA2	MESH:C089163	406141(Tax:7460)	Chemical	Gene	residues|amod|START_ENTITY subunit|appos|residues consists|nmod|subunit consists|nmod|activity activity|appos|END_ENTITY	The IpTxi dimer consists of a large subunit -LRB- 104-amino_acid residues -RRB- with phospholipase_A2 -LRB- PLA2 -RRB- activity covalently linked by a disulfide bond to a smaller -LRB- 27 amino_acid residues -RRB- , structurally unrelated subunit .
6328158	9	10-4M	1447,1452	TRH	1492,1495	10-4M	TRH	MESH:D008775	25569(Tax:10116)	Chemical	Gene	Atropine|appos|START_ENTITY abolished|nsubj|Atropine abolished|dobj|- -|appos|END_ENTITY	Atropine -LRB- 10-4M -RRB- almost completely abolished DN-1417 - , _ TRH - and carbachol-induced cyclic_AMP formation in the presence and absence of pentobarbital .
9809072	7	1052-amino-acid	939,954	S1P	918,921	1052-amino-acid	S1P	MESH:C000591384	8720	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|appos|protease	The cDNA encodes S1P , an intraluminal 1052-amino-acid membrane-bound subtilisin-like protease .
16584805	6	1053-1066	1048,1057	vinculin	995,1003	1053-1066	vinculin	MESH:C519885	22330(Tax:10090)	Chemical	Gene	residues|nummod|START_ENTITY arm|appos|residues lacking|dobj|arm used|xcomp|lacking used|dobj|mutant mutant|compound|END_ENTITY	To investigate the role of the vinculin/PIP2 interaction in FA dynamics , we used a vinculin mutant lacking the C-terminal arm -LRB- residues 1053-1066 -RRB- and referred to as the deltaC mutation .
11244063	4	1,055-amino-acid	636,652	YEF3	722,726	1,055-amino-acid	YEF3	null	850951(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY encode|dobj|protein found|xcomp|encode found|conj|has has|dobj|identity identity|appos|END_ENTITY	CnEF3 was found to encode a 1,055-amino-acid protein and has 44 % identity with EF3 from Saccharomyces_cerevisiae -LRB- YEF3 -RRB- .
26045558	3	1058-1062	491,500	Pax6	318,322	1058-1062	Pax6	MESH:C059545	5080	Chemical	Gene	Nature|nummod|START_ENTITY A.|dep|Nature Mass|conj|A. mice|dep|Mass phenotype|nmod|mice humans|conj|phenotype cause|nmod|humans cause|nsubj|Defects Defects|nmod|END_ENTITY	Defects in Pax6 cause aniridia_and_LSC_deficiency in humans and the Sey -LRB- Small eye -RRB- phenotype in mice -LRB- Mass , K. , Bhamra , S. , Eason , R. , Dale , N. , and Jones , E. A. -LRB- 2007 -RRB- Nature 449 , 1058-1062 -RRB- .
8752124	1	105-amino-acid	154,168	CT105	179,184	105-amino-acid	CT105	null	884093(Tax:272561)	Chemical	Gene	fragment|amod|START_ENTITY fragment|appos|END_ENTITY	We have previously shown that a recombinant carboxyl-terminal 105-amino-acid fragment -LRB- CT105 -RRB- of the amyloid precursor protein -LRB- APP -RRB- induced strong non-selective inward currents in Xenopus oocytes .
8242252	13	10-5M	1974,1979	ET-1	1906,1910	10-5M	ET-1	MESH:D008775	24323(Tax:10116)	Chemical	Gene	BQ-123|appos|START_ENTITY antagonized|nmod|BQ-123 antagonized|nsubj|effects effects|nmod|END_ENTITY	These direct effects of ET-1 or SX6b were strongly antagonized -LRB- 100 fold -RRB- by either BQ-123 -LRB- 10-5M -RRB- or PD 142893 -LRB- 10-5_M -RRB- .
6328158	4	10-5M	735,740	TRH	745,748	10-5M	TRH	MESH:D008775	25569(Tax:10116)	Chemical	Gene	DN-1417|appos|START_ENTITY DN-1417|conj|END_ENTITY	A concomitant application of DN-1417 -LRB- 10-5M -RRB- or TRH -LRB- 10-4M -RRB- and pentobarbital -LRB- 5 x 10-4M -RRB- led to a partial recovery of the pentobarbital effect .
8032583	15	10-5_M	1503,1509	ET-1	1585,1589	10-5 M	ET-1	MESH:D008775	100726197	Chemical	Gene	BQ-123|appos|START_ENTITY had|nsubj|BQ-123 had|nmod|epithelium epithelium|acl|induced induced|nmod|END_ENTITY	BQ-123 -LRB- 10-5_M -RRB- had no effect on contractions of the trachea without epithelium induced by ET-1 , but FR139317 -LRB- 10-5_M -RRB- caused a significant inhibition .
8032583	21	10-5_M	2460,2466	ET-1	2378,2382	10-5 M	ET-1	MESH:D008775	100726197	Chemical	Gene	BQ-123|appos|START_ENTITY attenuated|nmod|BQ-123 was|conj|attenuated was|nsubj|action action|nmod|END_ENTITY	The contractile action of ET-1 in the lung parenchyma was significantly and similarly attenuated by BQ-123 -LRB- 10-5_M -RRB- or indomethacin -LRB- 10-5_M -RRB- , while FRI39317 -LRB- 10-5_M -RRB- was less effective .
10594403	10	10-6-10-4_M	1289,1300	gastrin	1312,1319	10-6-10-4 M	gastrin	MESH:C052091	100345451(Tax:9986)	Chemical	Gene	dimaprit|appos|START_ENTITY increased|nsubj|dimaprit increased|dobj|release release|compound|END_ENTITY	The histamine H2-receptor agonist dimaprit -LRB- 10-6-10-4_M -RRB- increased gastrin release from 2.4 + / - 0.2 % to 3.6 + / - 0.2 % TCC -LRB- P < 0.001 -RRB- .
10594403	7	10-6-10-4_M	819,830	gastrin	868,875	10-6-10-4 M	gastrin	MESH:C052091	100345451(Tax:9986)	Chemical	Gene	NalphaMH|appos|START_ENTITY NalphaMH|acl:relcl|caused caused|nmod|release release|compound|END_ENTITY	RESULTS : NalphaMH -LRB- 10-6-10-4_M -RRB- caused a dose-dependent increase in gastrin release from a basal level of 2.3 + / - 0.2 % total cell content -LRB- TCC ; mean + / - S.E.M. -RRB- to a maximum of 5.1 + / - 0.7 % , an increase of 117 % -LRB- P < 0 .
17301166	3	106-126	617,624	PrP	520,523	106-126	PrP	MESH:C077829	19122(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	We investigated the biological activity of PrP 82-146 and of two nonamyloidogenic variants of PrP 82-146 with scrambled amino_acid sequence 106-126 or 127-146 .
17301166	3	106-126	617,624	PrP	571,574	106-126	PrP	MESH:C077829	19122(Tax:10090)	Chemical	Gene	START_ENTITY|conj|variants variants|nmod|END_ENTITY	We investigated the biological activity of PrP 82-146 and of two nonamyloidogenic variants of PrP 82-146 with scrambled amino_acid sequence 106-126 or 127-146 .
15642460	1	106-137	98,105	CAP18	92,97	106-137	CAP18	MESH:C004219	820	Chemical	Gene	END_ENTITY|appos|START_ENTITY	Five peptides : BPI -LRB- 85-109 -RRB- ; CAP18 -LRB- 106-137 -RRB- ; endotoxin inhibitor -LRB- EI -RRB- ; GQ33 and GQ33C , derived from lipopolysaccharide -LRB- LPS -RRB- - binding molecules were investigated for LPS-binding ability with a view to a potential use in extracorporeal therapy .
15642460	5	106-137	695,702	CAP18	689,694	106-137	CAP18	MESH:C004219	820	Chemical	Gene	peptide|appos|START_ENTITY peptide|compound|END_ENTITY	The CAP18 -LRB- 106-137 -RRB- peptide , which exhibited the highest binding efficacy and binding stability , was also immobilized on a poly -LRB- ethylene_imine -RRB- - poly -LRB- ethylene_glycol -RRB- -LRB- PEI-PEG -RRB- surface through maleimide-terminal_PEG .
15642460	6	106-137	934,941	CAP18	928,933	106-137	CAP18	MESH:C004219	820	Chemical	Gene	peptide|appos|START_ENTITY peptide|compound|END_ENTITY	The binding efficacy of the CAP18 -LRB- 106-137 -RRB- peptide was not significantly affected by the different immobilization methods used in the attachment to a dextran or a PEI-PEG_surface .
15642460	7	106-137	1111,1118	CAP18	1105,1110	106-137	CAP18	MESH:C004219	820	Chemical	Gene	END_ENTITY|appos|START_ENTITY	LPS bound selectively to CAP18 -LRB- 106-137 -RRB- and showed very low unspecific binding to the PEI-PEG_surface layer .
9056004	0	106-137	47,54	CAP18	41,46	106-137	CAP18	MESH:C004219	100009142(Tax:9986)	Chemical	Gene	END_ENTITY|appos|START_ENTITY	Antimicrobial action of rabbit leukocyte CAP18 -LRB- 106-137 -RRB- .
9056004	1	106-137	202,209	CAP18	196,201	106-137	CAP18	MESH:C004219	100009142(Tax:9986)	Chemical	Gene	END_ENTITY|appos|START_ENTITY	CAP18 is a cationic antimicrobial protein originally isolated from rabbit neutrophils , of which a 32-mer sequence from its C-terminal and -LRB- CAP18 -LRB- 106-137 -RRB- -RRB- has been found to be the most active .
9056004	1	106-137	202,209	CAP18	57,62	106-137	CAP18	MESH:C004219	100009142(Tax:9986)	Chemical	Gene	CAP18|appos|START_ENTITY found|nsubjpass|CAP18 neutrophils|acl:relcl|found isolated|nmod|neutrophils protein|acl|isolated protein|nsubj|END_ENTITY	CAP18 is a cationic antimicrobial protein originally isolated from rabbit neutrophils , of which a 32-mer sequence from its C-terminal and -LRB- CAP18 -LRB- 106-137 -RRB- -RRB- has been found to be the most active .
9056004	6	106-137	1609,1616	CAP18	1603,1608	106-137	CAP18	MESH:C004219	100009142(Tax:9986)	Chemical	Gene	END_ENTITY|appos|START_ENTITY	We conclude that CAP18 -LRB- 106-137 -RRB- exerts a rapid and profound action on E. _ coli cytoplasmic membranes and viability as measured by colony formation .
19050042	4	1062-amino-acid	460,475	Inv	441,444	1062-amino-acid	Inv	null	16348(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The mouse Inv gene encodes a 1062-amino-acid protein that is localized in primary cilia .
1709157	2	1066-amino_acid	111,126	Vinculin	97,105	1066-amino acid	Vinculin	MESH:C519885	7414	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Vinculin is a 1066-amino_acid protein found at several types of actin-membrane junction .
18203193	9	1067G	1177,1182	ACVR1	1133,1138	1067G	ACVR1	null	90	Chemical	Gene	A|nummod|START_ENTITY mutation|nsubj|A suggested|ccomp|mutation suggested|nsubj|Typing Typing|nmod|SNPs SNPs|acl|located located|nmod|region region|acl|spanning spanning|dobj|END_ENTITY	Typing of SNPs located in the approximately 0.5-Mb region spanning ACVR1 and its neighbor genes suggested that 1067G _ > _ A is a de novo mutation .
16225879	5	1068H	724,729	ABCA1	945,950	1068H	ABCA1	null	19	Chemical	Gene	alleles|nummod|START_ENTITY Haplotyping|nmod|alleles showed|nsubj|Haplotyping reported|ccomp|showed reported|xcomp|associated associated|nmod|expression expression|compound|END_ENTITY	Haplotyping of both 1068H alleles in the proband showed homozygosity in the coding region , however , the maternal 1068H allele had three single nucleotide polymorphisms -LRB- SNPs -RRB- in the promoter previously reported to be associated with reduced ABCA1 expression and HDL levels .
10527855	4	106-amino-acid	648,662	CRM1	610,614	106-amino-acid	CRM1	MESH:C588327	7514	Chemical	Gene	region|amod|START_ENTITY 81|conj|region binds|nmod|81 binds|nsubj|END_ENTITY	CRM1 binds specifically to the 81 - to 106-amino-acid -LRB- aa -RRB- region of NS2 , and the region of NS2 actually functions as a NES .
15504869	5	106-amino-acid	710,724	PMP-1	685,690	106-amino-acid	PMP-1	MESH:C588327	5824	Chemical	Gene	precursor|amod|START_ENTITY translated|nmod|precursor translated|nsubjpass|END_ENTITY	PMP-1 is translated as a 106-amino-acid precursor and is processed to yield 73-residue -LRB- 8,053 Da -RRB- and 72-residue -LRB- 7,951-Da -RRB- variants .
11920196	6	106-amino-acid	1072,1086	Spna1	942,947	106-amino-acid	Spna1	null	20739(Tax:10090)	Chemical	Gene	structure|amod|START_ENTITY shows|dobj|structure sequence|acl:relcl|shows deduced|dobj|sequence reveals|ccomp|deduced reveals|nsubj|Sequencing Sequencing|nmod|region region|nmod|allele allele|amod|END_ENTITY	Sequencing of the full length coding region of the Spna1 wild type allele from the C57BL/6J strain of mice reveals a 2414 residue deduced amino_acid sequence that shows the typical 106-amino-acid repeat structure previously described for other members of the spectrin protein family .
10594403	11	10-7-10-4_M	1429,1440	Gastrin	1379,1386	10-7-10-4 M	Gastrin	MESH:C040211	100345451(Tax:9986)	Chemical	Gene	histamine|appos|START_ENTITY stimulated|nmod|histamine stimulated|nsubjpass|release release|compound|END_ENTITY	Gastrin release was also stimulated by histamine -LRB- 10-7-10-4_M -RRB- from a basal value of 3.0 + / - 0.3 % to 5.4 + / - 0.5 % TCC -LRB- P < 0.001 -RRB- .
1306984	0	107-111	43,50	parathyroid_hormone-related_peptide	6,41	107-111	parathyroid hormone-related peptide	MESH:C071784	19227(Tax:10090)	Chemical	Gene	-|appos|START_ENTITY -|amod|END_ENTITY	Human parathyroid_hormone-related_peptide - -LRB- 107-111 -RRB- does not inhibit bone resorption in neonatal mouse calvariae .
9611193	11	1071-amino-acid	1214,1229	Prp16	1230,1235	1071-amino-acid	Prp16	MESH:C000596159	853961(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Deletion analysis of the 1071-amino-acid Prp16 protein revealed that the N-terminal 204 amino_acids and the C-terminal 100 residues were dispensable for PRP16 function in vivo .
9611193	11	1071-amino-acid	1214,1229	PRP16	1342,1347	1071-amino-acid	PRP16	MESH:C000596159	853961(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY analysis|nmod|protein revealed|nsubj|analysis revealed|ccomp|dispensable dispensable|nmod|function function|nummod|END_ENTITY	Deletion analysis of the 1071-amino-acid Prp16 protein revealed that the N-terminal 204 amino_acids and the C-terminal 100 residues were dispensable for PRP16 function in vivo .
19103596	3	1075AAAQN1079	880,893	AE2	847,850	1075AAAQN1079	AE2	MESH:C042264	6522	Chemical	Gene	1075AAAQ1078|conj|START_ENTITY mutants|dep|1075AAAQ1078 RL1|amod|mutants RL1|compound|END_ENTITY	AE2 RL1 mutants 1075AAAQ1078 and 1075AAAQN1079 showed reduced pHi sensitivity and pHo sensitivity was acid-shifted by approximately 1 pH unit .
19103596	3	1075AAAQN1079	880,893	pHi	909,912	1075AAAQN1079	pHi	MESH:C042264	2821	Chemical	Gene	1075AAAQ1078|conj|START_ENTITY mutants|dep|1075AAAQ1078 RL1|amod|mutants showed|nsubj|RL1 showed|ccomp|acid-shifted acid-shifted|nsubjpass|sensitivity sensitivity|compound|END_ENTITY	AE2 RL1 mutants 1075AAAQ1078 and 1075AAAQN1079 showed reduced pHi sensitivity and pHo sensitivity was acid-shifted by approximately 1 pH unit .
12632087	11	1077-amino-acid	1236,1251	DAAM1	1352,1357	1077-amino-acid	DAAM1	null	23002	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|FH1 FH1|acl:relcl|showed showed|dobj|identity identity|nmod|END_ENTITY	DAAM2 was a 1077-amino-acid protein with Formin-homology FH1 and FH2 domains , which showed 68.9 % total-amino-acid identity with DAAM1 .
12632087	11	1077-amino-acid	1236,1251	DAAM2	1224,1229	1077-amino-acid	DAAM2	null	23500	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	DAAM2 was a 1077-amino-acid protein with Formin-homology FH1 and FH2 domains , which showed 68.9 % total-amino-acid identity with DAAM1 .
9920407	1	1078-amino-acid	90,105	calcium-sensing_receptor	53,77	1078-amino-acid	calcium-sensing receptor	null	846	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The human calcium-sensing_receptor -LRB- CaSR -RRB- is a 1078-amino-acid cell surface protein which is expressed in the parathyroids , thyroid cells and the kidney , and is a member of the family of G protein-coupled receptors .
9920407	1	1078-amino-acid	90,105	CaSR	79,83	1078-amino-acid	CaSR	null	846	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|calcium-sensing_receptor calcium-sensing_receptor|appos|END_ENTITY	The human calcium-sensing_receptor -LRB- CaSR -RRB- is a 1078-amino-acid cell surface protein which is expressed in the parathyroids , thyroid cells and the kidney , and is a member of the family of G protein-coupled receptors .
20589758	4	107-amino-acid	546,560	CTCF	571,575	107-amino-acid	CTCF	null	10664	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|region region|nmod:poss|END_ENTITY	Using transient and integrated reporters , we identified a 107-amino-acid domain in CTCF 's N-terminal region that is capable of transcriptional activation and chromatin decondensation .
3316983	8	107-kilodalton	1244,1258	SSN6	1207,1211	107-kilodalton	SSN6	MESH:C415942	852410(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY encode|dobj|protein predicted|xcomp|encode END_ENTITY|acl:relcl|predicted	We also determined the nucleotide sequence of SSN6 , which is predicted to encode a 107-kilodalton protein with stretches of polyglutamine and poly -LRB- glutamine-alanine -RRB- .
12807786	4	1080-amino-acid	541,556	Lr21	508,512	1080-amino-acid	Lr21	null	100125728(Tax:4565)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein spans|conj|encodes spans|nsubj|END_ENTITY	Lr21 spans 4318 bp and encodes a 1080-amino-acid protein containing a conserved nucleotide-binding site -LRB- NBS -RRB- domain , 13 imperfect leucine-rich repeats -LRB- LRRs -RRB- , and a unique 151-amino-acid sequence missing from known NBS-LRR proteins at the N terminus .
22796424	5	1081-amino-acid	538,553	Drosha	516,522	1081-amino-acid	Drosha	null	29102	Chemical	Gene	peptide|amod|START_ENTITY encoded|dobj|peptide encoded|nsubj|gene gene|compound|END_ENTITY	The sequence analysis revealed that the shrimp Drosha gene encoded a 1081-amino-acid peptide , which comprised two tandem ribonuclease III C terminal domains and a double-stranded RNA binding motif .
19740703	7	1082-1G	899,906	PCFT	925,929	1082-1G	PCFT	MESH:C049454	113235	Chemical	Gene	>|nummod|START_ENTITY homozygous|dep|> homozygous|dep|found found|nsubjpass|mutation mutation|nmod|gene gene|amod|END_ENTITY	A homozygous 1082-1G > A mutation of the PCFT gene was found , resulting in skipping of exon 3 .
16210052	10	10841C	1445,1451	IL-12B	1561,1567	10841C	IL-12B	null	3593	Chemical	Gene	A|nummod|START_ENTITY affects|nsubj|A affects|conj|enhances enhances|dobj|level level|nmod|END_ENTITY	Furthermore , 10841C _ > _ A affects the stability of transcripts , and promoter variant -6415 GC enhances the transcriptional level of IL-12B .
10702296	3	1085-nucleotide	445,460	transaldolase	620,633	1085-nucleotide	transaldolase	MESH:D009711	6888	Chemical	Gene	transcript|amod|START_ENTITY contained|nsubj|transcript contained|xcomp|oriented oriented|nmod|direction direction|nmod|transcription transcription|nmod|gene gene|amod|END_ENTITY	A dominant 1085-nucleotide long transcript , TARE-6 , contained two adjacent Alu elements , a right monomer and a complete dimer , oriented opposite to the direction of transcription of the transaldolase gene .
9722942	5	1086_amino_acids	725,741	SOLH	709,713	1086 amino acids	SOLH	MESH:C108687	6650	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	The encoded SOLH protein of 1086_amino_acids has strong similarity to the D. _ melanogaster protein .
16961934	6	1086_amino_acids	1027,1043	TERT	981,985	1086 amino acids	TERT	MESH:C108687	7015	Chemical	Gene	protein|nmod|START_ENTITY encodes|dobj|protein cDNA|acl:relcl|encodes cDNA|compound|END_ENTITY	We have cloned and characterized a 3261-bp full-length TERT cDNA , omTERT , which encodes a protein of 1086_amino_acids .
16121037	1	1086-amino_acids	338,354	KCC1	263,267	1086-amino acids	KCC1	null	20498(Tax:10090)	Chemical	Gene	polypeptide|nmod|START_ENTITY encoding|dobj|polypeptide cloned|xcomp|encoding cloned|advcl|exhibiting exhibiting|nmod|cDNAs cDNAs|compound|END_ENTITY	Sheep K-Cl cotransporter-1 -LRB- shKCC1 -RRB- cDNA was cloned from kidney by RT-PCR with an open reading frame of 3258 base pairs exhibiting 92 % , 90 % , 88 % and 87 % identity with pig , rabbit and human , rat and mouse KCC1 cDNAs , respectively , encoding an approximately 122 kDa polypeptide of 1086-amino_acids .
15602741	2	1,087-nucleotide	855,871	Patients_C1I_and_C1S	741,761	1,087-nucleotide	Patients C1I and C1S	null	716	Chemical	Gene	sequence|amod|START_ENTITY %|nmod|sequence identity|nmod|% shared|dobj|identity C2I|acl|shared those|nmod|C2I reported|nsubj|those isolates|conj|reported isolates|nmod|END_ENTITY	The HCV isolates from Patients_C1I_and_C1S and those from Patients C2I and C2S shared identity of 99.9 % and 99.1 % , respectively , in the 1,087-nucleotide -LRB- nt -RRB- sequence of the NS5B region , although these four isolates were only 91.7 % -96.2 % identical to the 94 reported genotype 1b isolates including those from Japanese patients .
1522152	4	1089_amino_acids	753,769	PSE-1	646,651	1089 amino acids	PSE-1	MESH:C078903	855356(Tax:4932)	Chemical	Gene	containing|dobj|START_ENTITY located|xcomp|containing located|nsubjpass|gene gene|compound|END_ENTITY	The PSE-1 gene is located on chromosome XII of the yeast genome and codes for a hydrophobic protein containing 1089_amino_acids .
16725058	5	108-amino-acid	813,827	UNC-69	775,781	108-amino-acid	UNC-69	MESH:C072528	176444(Tax:6239)	Chemical	Gene	protein|amod|START_ENTITY identify|nmod|protein identify|dobj|END_ENTITY	We identify UNC-69 as an evolutionarily conserved 108-amino-acid protein with a short coiled-coil domain .
15201812	4	10-8_M_testosterone	764,783	AhR	665,668	10-8 M testosterone	AhR	MESH:D013739	11622(Tax:10090)	Chemical	Gene	vehicle|conj|START_ENTITY vitro|nmod|vehicle incubated|advcl|vitro removed|conj|incubated removed|nmod|WT WT|conj|END_ENTITY	MATERIALS AND METHODS : UGSs were removed from WT and AhR null mutant -LRB- AhRKO -RRB- male C57BL/6 mice on gestation day 14 and incubated in vitro with vehicle , 10-8_M_testosterone or 10-8_M_testosterone plus 10-9 M TCDD for 5 days .
20110366	3	10902-10910	433,444	ceramide_synthase_2	465,484	10902-10910	ceramide synthase 2	MESH:C086698	76893(Tax:10090)	Chemical	Gene	285|amod|START_ENTITY 285|amod|due due|nmod|ablation ablation|nmod|END_ENTITY	285 , 10902-10910 -RRB- due to ablation of ceramide_synthase_2 -LRB- CerS2 -RRB- .
20110366	3	10902-10910	433,444	CerS2	486,491	10902-10910	CerS2	MESH:C086698	76893(Tax:10090)	Chemical	Gene	285|amod|START_ENTITY 285|amod|due due|nmod|ablation ablation|nmod|ceramide_synthase_2 ceramide_synthase_2|appos|END_ENTITY	285 , 10902-10910 -RRB- due to ablation of ceramide_synthase_2 -LRB- CerS2 -RRB- .
20682279	4	109-123	561,568	SOD1	536,540	109-123	SOD1	MESH:C050088	6647	Chemical	Gene	residues|conj|START_ENTITY END_ENTITY|dep|residues	From our study of a panel of mutant proteins , we identify two sequence elements in human SOD1 -LRB- residues 42-50 and 109-123 -RRB- that are critical in modulating the aggregation of the protein .
11232017	5	109-141	673,680	PTHrP	685,690	109-141	PTHrP	MESH:C097725	5744	Chemical	Gene	carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal antibodies|nmod|END_ENTITY	Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line .
11232017	5	109-141	673,680	PTHrP	722,727	109-141	PTHrP	MESH:C097725	5744	Chemical	Gene	carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal identify|nsubj|antibodies identify|dobj|END_ENTITY	Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line .
11232017	5	109-141	673,680	PTHrP	741,746	109-141	PTHrP	MESH:C097725	5744	Chemical	Gene	carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal used|nsubjpass|antibodies used|conj|secreted secreted|dobj|END_ENTITY	Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line .
11232017	5	109-141	673,680	PTHrP	811,816	109-141	PTHrP	MESH:C097725	5744	Chemical	Gene	carboxyl-terminal_peptides|appos|START_ENTITY amino-terminal|conj|carboxyl-terminal_peptides antibodies|nmod|amino-terminal used|nsubjpass|antibodies used|conj|secreted secreted|dobj|PTHrP PTHrP|nmod|Western Western|conj|staining staining|nmod|END_ENTITY	Murine monoclonal antibodies to the amino-terminal -LRB- 1-34 -RRB- , mid-region -LRB- 38-64 -RRB- , and carboxyl-terminal_peptides -LRB- 109-141 -RRB- of PTHrP were used to identify cellular PTHrP and secreted PTHrP , including Western blotting and immunocytochemical staining for PTHrP from each cell line .
8977313	9	109203X	1807,1814	Apo-1	1906,1911	109203X	Apo-1	null	355	Chemical	Gene	GF|nummod|START_ENTITY inhibited|nsubj|GF inhibited|nmod|apoptosis apoptosis|amod|/ /|amod|END_ENTITY	Furthermore , the bis-indolylmaleimide GF 109203X , a specific inhibitor of PKC , inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1 / Fas-induced apoptosis .
8977313	9	109203X	1807,1814	IFN-alpha2	1892,1902	109203X	IFN-alpha2	null	3440	Chemical	Gene	GF|nummod|START_ENTITY inhibited|nsubj|GF inhibited|dobj|effect effect|conj|that that|nmod|END_ENTITY	Furthermore , the bis-indolylmaleimide GF 109203X , a specific inhibitor of PKC , inhibited the effect of PMA as well as that of IFN-alpha2 on Apo-1 / Fas-induced apoptosis .
3500169	6	1094-1099	862,871	s-mephenytoin_4-hydroxylase	739,766	1094-1099	s-mephenytoin 4-hydroxylase	MESH:C045621	1557	Chemical	Gene	Biochemistry|nummod|START_ENTITY P.|dep|Biochemistry Umbenhauer|conj|P. END_ENTITY|dep|Umbenhauer	The human P-450 1 is 82 % homologous to the s-mephenytoin_4-hydroxylase -LRB- Umbenhauer , D. R. , Martin , M. V. , Lloyd , R. S. , and Guengerich , F. P. -LRB- 1987 -RRB- Biochemistry 26 , 1094-1099 -RRB- .
15137909	3	1095-1106	739,748	AD1	813,816	1095-1106	AD1	MESH:C121396	351	Chemical	Gene	-RSB-|nsubj|START_ENTITY -RSB-|nmod|domain domain|appos|END_ENTITY	Here , we identified two CBP-interacting sites -LSB- amino_acids_1075-1083 -LRB- site I -RRB- and 1095-1106 -LRB- site II -RRB- -RSB- in a so-called CBP-dependent transactivation domain -LRB- AD1 ; amino acids_1057-1109 -RRB- of GRIP1 .
15137909	3	1095-1106	739,748	GRIP1	844,849	1095-1106	GRIP1	MESH:C121396	10499	Chemical	Gene	-RSB-|nsubj|START_ENTITY -RSB-|nmod|domain domain|nmod|END_ENTITY	Here , we identified two CBP-interacting sites -LSB- amino_acids_1075-1083 -LRB- site I -RRB- and 1095-1106 -LRB- site II -RRB- -RSB- in a so-called CBP-dependent transactivation domain -LRB- AD1 ; amino acids_1057-1109 -RRB- of GRIP1 .
15897884	2	1098-amino-acid	463,478	MYO1F	397,402	1098-amino-acid	MYO1F	null	4542	Chemical	Gene	domains|amod|START_ENTITY encode|dobj|domains predicted|xcomp|encode consists|conj|predicted consists|nsubj|END_ENTITY	MYO1F consists of at least 28 exons and was predicted to encode a 1098-amino-acid with an N-terminal head domain containing both ATP-binding and actin-binding sequences , a neck domain with a single IQ motif , and a tail with TH1 , TH2 and SH3 domains .
15897884	2	1098-amino-acid	463,478	TH1	621,624	1098-amino-acid	TH1	null	51497	Chemical	Gene	START_ENTITY|nmod|domain domain|acl|containing containing|dobj|ATP-binding ATP-binding|conj|tail tail|nmod|END_ENTITY	MYO1F consists of at least 28 exons and was predicted to encode a 1098-amino-acid with an N-terminal head domain containing both ATP-binding and actin-binding sequences , a neck domain with a single IQ motif , and a tail with TH1 , TH2 and SH3 domains .
12410208	1	109AGC	340,346	carnitine_palmitoyltransferase_II	218,251	109AGC	carnitine palmitoyltransferase II	null	1376	Chemical	Gene	_|nummod|START_ENTITY Q413fs|conj|_ mutations|dep|Q413fs heterozygosity|nmod|mutations deficiency|nmod|heterozygosity deficiency|amod|END_ENTITY	We describe a lethal neonatal form of carnitine_palmitoyltransferase_II -LRB- CPT_II -RRB- deficiency with compound heterozygosity for 2 truncation mutations -LRB- Q413fs and 109AGC _ -- > _ GCAGC -RRB- .
12410208	1	109AGC	340,346	CPT_II	253,259	109AGC	CPT II	null	1376	Chemical	Gene	_|nummod|START_ENTITY Q413fs|conj|_ mutations|dep|Q413fs heterozygosity|nmod|mutations deficiency|nmod|heterozygosity deficiency|appos|END_ENTITY	We describe a lethal neonatal form of carnitine_palmitoyltransferase_II -LRB- CPT_II -RRB- deficiency with compound heterozygosity for 2 truncation mutations -LRB- Q413fs and 109AGC _ -- > _ GCAGC -RRB- .
1649341	3	109-amino-acid	682,696	gp70	618,622	109-amino-acid	gp70	null	133418	Chemical	Gene	region|amod|START_ENTITY achieved|nmod|region depended|conj|achieved depended|nmod|region region|nmod|terminus terminus|nmod|gene gene|amod|END_ENTITY	T-cell killing depended on changes within a 7-amino-acid region near the C terminus of the gp70 env gene or was achieved independently by changes within a 109-amino-acid region encompassing the N terminus of gp70 .
1649341	3	109-amino-acid	682,696	gp70	735,739	109-amino-acid	gp70	null	133418	Chemical	Gene	region|amod|START_ENTITY region|acl|encompassing encompassing|dobj|terminus terminus|nmod|END_ENTITY	T-cell killing depended on changes within a 7-amino-acid region near the C terminus of the gp70 env gene or was achieved independently by changes within a 109-amino-acid region encompassing the N terminus of gp70 .
7236494	2	109CdCl2	801,809	Cd2	824,827	109CdCl2	Cd2	null	497761(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY revealed|nsubj|studies revealed|ccomp|distributed distributed|nsubjpass|+ +|compound|END_ENTITY	Autoradiographic studies with 109CdCl2 revealed that Cd2 + , accumulated by the kidney under these conditions , was not uniformly distributed throughout the renal cortex , but was concentrated unevenly in proximal tubules in the outer stripe of the outer zone of the medulla .
7570600	1	109CdCl2	261,269	Cd-MT	165,170	109CdCl2	Cd-MT	null	74256(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY examined|nmod|injection examined|nsubjpass|effects effects|nmod|erythropoiesis erythropoiesis|nmod|cadmium-metallothionein cadmium-metallothionein|appos|END_ENTITY	The effects of erythropoiesis on cadmium-metallothionein -LRB- Cd-MT -RRB- 2 levels in spleen , a major erythropoietic tissue , was examined following sc injection of 109CdCl2 into mice .
16335400	3	109G	707,711	Cx26	645,649	109G	Cx26	MESH:C420352	2706	Chemical	Gene	A|amod|START_ENTITY ,79|dep|A sequence|dep|,79 sequence|nmod|gene gene|amod|END_ENTITY	RESULTS : Compared with the reference sequence of Cx26 gene , totally four kinds of nucleotide changes ,79 G _ -- > A , 109G -- > A , 341G -- > A and 235delC , were detected in a heterozygous form .
8102392	3	10-acetate	246,256	C-2	320,323	10-acetate	C-2	null	717	Chemical	Gene	hydrolyzed|nsubjpass|START_ENTITY hydrolyzed|advcl|C-4_acetate C-4_acetate|conj|cyclohexylcarboxylate cyclohexylcarboxylate|compound|END_ENTITY	The 10-acetate was hydrolyzed first , followed by the C-4_acetate and then the C-2 cyclohexylcarboxylate ; an explanation for this unexpected order is presented .
23167949	6	10-acetyl	1094,1103	C-10	1140,1144	10-acetyl	C-10	null	3226	Chemical	Gene	substituent|amod|START_ENTITY substituent|nmod|position position|compound|END_ENTITY	Bisulfite bonded to the carbonyl of 10-acetyl substituent instead of the expected C-10 position of the pyranoanthocyanin core , thus giving rise to a red pigment hypsochromically shifted toward orangish nuances -LRB- maximum absorbances at 487-491 nm -RRB- .
21902186	1	10-acetylirciformonin_B	211,234	C21	90,93	10-acetylirciformonin B	C21	MESH:C562206	79718	Chemical	Gene	15-acetylirciformonin_B|conj|START_ENTITY compounds|amod|15-acetylirciformonin_B ircinolin_A|conj|compounds product|appos|ircinolin_A product|amod|END_ENTITY	One novel C21 terpenoidal natural product , ircinolin_A -LRB- 2 -RRB- , two new C22 furanoterpene metabolites , 15-acetylirciformonin_B -LRB- 3 -RRB- and 10-acetylirciformonin_B -LRB- 4 -RRB- , and two known compounds , irciformonin_B -LRB- 1 -RRB- and irciformonin_F -LRB- 5 -RRB- , were isolated from the sponge Ircinia sp .
3222264	0	10-acyl	129,136	glucose-6-phosphate_dehydrogenase	73,106	10-acyl	glucose-6-phosphate dehydrogenase	null	2539	Chemical	Gene	derivatives|amod|START_ENTITY inhibition|nmod|derivatives inhibition|compound|synthesis synthesis|conj|END_ENTITY	-LSB- Senecioyldithranol and beta-carbethoxypropionyldithranol : synthesis and glucose-6-phosphate_dehydrogenase inhibition of two new 10-acyl derivatives of the antipsoriatic , dithranol -RSB- .
1123034	3	10-Acyl	407,414	VIII	455,459	10-Acyl	VIII	null	1351	Chemical	Gene	START_ENTITY|conj|10-beta-cyanoethyl 10-beta-cyanoethyl|dep|VII VII|dep|END_ENTITY	10-Acyl -LRB- III - VI -RRB- and 10-beta-cyanoethyl -LRB- VII , VIII -RRB- derivatives of compounds -LRB- I -RRB- and -LRB- II -RRB- were easy obtained in good yield .
17229142	3	10-alanine	535,545	PABPN1	493,499	10-alanine	PABPN1	null	8106	Chemical	Gene	segment|amod|START_ENTITY extension|nmod|segment result|nmod|extension binding_protein_1|acl:relcl|result binding_protein_1|appos|END_ENTITY	The disorder is caused by trinucleotide -LRB- GCG -RRB- expansions in the N-terminal part of the poly -LRB- A -RRB- - binding_protein_1 -LRB- PABPN1 -RRB- that result in the extension of a 10-alanine segment by up to seven more alanines .
2426568	1	10-alkyl	137,145	thymidylate_synthase	192,212	10-alkyl	thymidylate synthase	null	7298	Chemical	Gene	derivatives|amod|START_ENTITY 10-deazaaminopterin|conj|derivatives 10-deazaaminopterin|conj|polyglutamates polyglutamates|nmod|END_ENTITY	The action of 10-deazaaminopterin , its 10-alkyl derivatives , and their polyglutamates against thymidylate_synthase -LRB- TMPS -RRB- from human acute_myeloblastic_leukemia was examined .
1381398	6	1-0-alkyl-2-acetyl_sn-glycero-3-phosphocholine	1379,1425	IL-8	1470,1474	1-0-alkyl-2-acetyl sn-glycero-3-phosphocholine	IL-8	null	3576	Chemical	Gene	agonists|amod|START_ENTITY agonists|acl:relcl|produced produced|nmod|END_ENTITY	In contrast , two other neutrophil agonists 1-0-alkyl-2-acetyl_sn-glycero-3-phosphocholine and granulocyte-macrophage-CSF , which , like IL-8 , are produced by activated HUVEC , as well as the leukocyte-derived chemoattractant leukotriene B4 , exerted minimal inhibitory effects on adhesion .
2325013	1	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	260,306	PAF	255,258	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	PAF	null	109585(Tax:10090)	Chemical	Gene	END_ENTITY|dep|START_ENTITY	When male mouse spleen cells were incubated with a combination of platelet_activating_factor -LRB- PAF , 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- and sera from female mice in oestrus , the cells displayed a markedly increased rosette inhibition titre -LRB- RIT -RRB- when subsequently tested in the rosette inhibition assay .
3110054	5	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	1024,1070	PAF	1019,1022	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	PAF	null	9768	Chemical	Gene	END_ENTITY|dep|START_ENTITY	In particular , platelet-activating_factor -LRB- PAF ; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- was found to cause rapid , but transient , increases in -LSB- Ca2 + -RSB- i -LRB- from resting levels of about 70 nM to peaks of about 400 nM -RRB- even at concentrations as low as 10 -LRB- -10 -RRB- M .
2325013	1	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	260,306	platelet_activating_factor	227,253	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	platelet activating factor	null	109585(Tax:10090)	Chemical	Gene	PAF|dep|START_ENTITY END_ENTITY|dep|PAF	When male mouse spleen cells were incubated with a combination of platelet_activating_factor -LRB- PAF , 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- and sera from female mice in oestrus , the cells displayed a markedly increased rosette inhibition titre -LRB- RIT -RRB- when subsequently tested in the rosette inhibition assay .
3110054	5	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	1024,1070	platelet-activating_factor	991,1017	1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine	platelet-activating factor	null	9768	Chemical	Gene	PAF|dep|START_ENTITY END_ENTITY|appos|PAF	In particular , platelet-activating_factor -LRB- PAF ; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine -RRB- was found to cause rapid , but transient , increases in -LSB- Ca2 + -RSB- i -LRB- from resting levels of about 70 nM to peaks of about 400 nM -RRB- even at concentrations as low as 10 -LRB- -10 -RRB- M .
2466463	1	1-0-alkyl-2-acylglycerol	204,228	AAG	198,201	1-0-alkyl-2-acylglycerol	AAG	null	4350	Chemical	Gene	1,2-diacylglycerol|conj|START_ENTITY 1,2-diacylglycerol|appos|END_ENTITY	Quantitation of 1,2-diacylglycerol -LRB- AAG -RRB- , 1-0-alkyl-2-acylglycerol -LRB- EAG -RRB- and phosphatidic_acid -LRB- PA -RRB- was conducted in polymorphonuclear leukocytes -LRB- PMN -RRB- labeled with 1-0 - -LSB- 3H -RSB- alkyl-2-acyl-GPC following stimulation with 1 microM fMLP using Coomassie blue staining and densitometry .
2466463	1	1-0-alkyl-2-acylglycerol	204,228	fMLP	388,392	1-0-alkyl-2-acylglycerol	fMLP	null	2357	Chemical	Gene	1,2-diacylglycerol|conj|START_ENTITY Quantitation|nmod|1,2-diacylglycerol conducted|nsubjpass|Quantitation conducted|parataxis|using using|nsubj|stimulation stimulation|nmod|END_ENTITY	Quantitation of 1,2-diacylglycerol -LRB- AAG -RRB- , 1-0-alkyl-2-acylglycerol -LRB- EAG -RRB- and phosphatidic_acid -LRB- PA -RRB- was conducted in polymorphonuclear leukocytes -LRB- PMN -RRB- labeled with 1-0 - -LSB- 3H -RSB- alkyl-2-acyl-GPC following stimulation with 1 microM fMLP using Coomassie blue staining and densitometry .
3422154	1	1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine	211,255	phospholipase_D	90,105	1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine	phospholipase D	null	2822	Chemical	Gene	endogenous|amod|START_ENTITY labeled|nmod|endogenous granulocytes|acl|labeled investigated|nmod|granulocytes investigated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of phospholipase_D -LRB- PLD -RRB- has been investigated in dimethylsulfoxide differentiated HL-60 granulocytes labeled in endogenous 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine -LRB- alkyl-PC -RRB- by incubation with -LSB- 3H -RSB- alkyl-lysoPC .
3422154	1	1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine	211,255	PLD	107,110	1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine	PLD	null	2822	Chemical	Gene	endogenous|amod|START_ENTITY labeled|nmod|endogenous granulocytes|acl|labeled investigated|nmod|granulocytes investigated|nsubjpass|Activation Activation|appos|END_ENTITY	Activation of phospholipase_D -LRB- PLD -RRB- has been investigated in dimethylsulfoxide differentiated HL-60 granulocytes labeled in endogenous 1-0-alkyl-2-acyl-sn-glycero-3-phosphocholine -LRB- alkyl-PC -RRB- by incubation with -LSB- 3H -RSB- alkyl-lysoPC .
1335527	6	1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine	1365,1413	phospholipase_A2	1417,1433	1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine	phospholipase A2	MESH:C036761	5319	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity .
1335527	6	1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine	1365,1413	PLA2	1435,1439	1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine	PLA2	MESH:C036761	5319	Chemical	Gene	START_ENTITY|nmod|phospholipase_A2 phospholipase_A2|appos|END_ENTITY	Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity .
7517616	2	1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline	425,470	calcium-dependent_phospholipase_A2	320,354	1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline	calcium-dependent phospholipase A2	null	5322	Chemical	Gene	yield|xcomp|START_ENTITY phospholipid|xcomp|yield hydrolyzes|ccomp|phospholipid activated|ccomp|hydrolyzes activated|nsubjpass|END_ENTITY	Upon cell stimulation a calcium-dependent_phospholipase_A2 -LRB- PLA2 -RRB- is activated which hydrolyzes a membrane phospholipid to yield 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline -LRB- lyso-PAF -RRB- and free arachidonic_acid .
7517616	2	1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline	425,470	PLA2	356,360	1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline	PLA2	null	5320	Chemical	Gene	yield|xcomp|START_ENTITY phospholipid|xcomp|yield hydrolyzes|ccomp|phospholipid activated|ccomp|hydrolyzes activated|nsubjpass|calcium-dependent_phospholipase_A2 calcium-dependent_phospholipase_A2|appos|END_ENTITY	Upon cell stimulation a calcium-dependent_phospholipase_A2 -LRB- PLA2 -RRB- is activated which hydrolyzes a membrane phospholipid to yield 1-0-alkyl-2-lyso-sn-glycero-3-phospho-choline -LRB- lyso-PAF -RRB- and free arachidonic_acid .
6094787	1	10-alkylaminophenothiazines	198,225	calmodulin	143,153	10-alkylaminophenothiazines	calmodulin	null	801	Chemical	Gene	quaternary_methiodide_salts|nmod|START_ENTITY prepared|nsubjpass|quaternary_methiodide_salts prepared|advcl|clarify clarify|nmod|the the|nmod|phenothiazines phenothiazines|nmod|END_ENTITY	To clarify the role of electrostatic forces in the binding of phenothiazines to calmodulin , the quaternary_methiodide_salts of several 10-alkylaminophenothiazines were prepared and examined for anticalmodulin activity .
1517691	1	1-0-alkyl-glycero-3-phosphocholine	272,306	C5a	202,205	1-0-alkyl-glycero-3-phosphocholine	C5a	MESH:C029271	362119(Tax:10116)	Chemical	Gene	transferase|amod|START_ENTITY A|dep|transferase A|amod|activation activation|conj|components components|appos|C3a C3a|dep|END_ENTITY	The effects of in vitro complement activation and of isolated complement components -LRB- C3a , C5a , C3b -RRB- on the activity of the microsomal enzyme acetyl coenzyme A : 1-0-alkyl-glycero-3-phosphocholine acetyl transferase -LRB- AcTr -RRB- in cultured mesangial cells and on the synthesis of prostaglandin_E2 -LRB- PGE2 -RRB- were assessed .
15995176	6	1-0-alkyl-sn-glycero-3-phosphocholine	1093,1130	PAF-AH	1150,1156	1-0-alkyl-sn-glycero-3-phosphocholine	PAF-AH	null	7941	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|amod|END_ENTITY	However , upon LDL oxidation in the presence of exogenous 1-0-alkyl-sn-glycero-3-phosphocholine -LRB- lyso-PAF -RRB- without PAF-AH inactivation , C16 :0 PAF formation accounted for > 90 % of the biological activity recovered .
1335527	6	1-0-alkyl-sn-glyceryl-3-phosphorylcholine	1295,1336	phospholipase_A2	1417,1433	1-0-alkyl-sn-glyceryl-3-phosphorylcholine	phospholipase A2	MESH:C029419	5319	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|activity activity|amod|1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine|nmod|END_ENTITY	Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity .
1335527	6	1-0-alkyl-sn-glyceryl-3-phosphorylcholine	1295,1336	PLA2	1435,1439	1-0-alkyl-sn-glyceryl-3-phosphorylcholine	PLA2	MESH:C029419	5319	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|activity activity|amod|1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine|nmod|phospholipase_A2 phospholipase_A2|appos|END_ENTITY	Experiments with labeled precursors demonstrated that in MC , either after stimulation with porins or LPS , PAF was synthesized via the remodeling pathway that involves acetylation of 1-0-alkyl-sn-glyceryl-3-phosphorylcholine -LRB- 2-lyso-PAF -RRB- generated from 1-0-alkyl-2-acyl-sn-glyceryl-3-phosphorylcholine by phospholipase_A2 -LRB- PLA2 -RRB- activity .
17940284	1	10-amino_acid	226,239	Atp6p	121,126	10-amino acid	Atp6p	null	854601(Tax:4932)	Chemical	Gene	presequence|amod|START_ENTITY synthesized|nmod|presequence synthesized|nsubjpass|END_ENTITY	Atp6p -LRB- subunit 6 -RRB- of the Saccharomyces_cerevisiae mitochondrial ATPase is synthesized with an N-terminal 10-amino_acid presequence that is cleaved during assembly of the complex .
8497191	10	10-amino_acid	1412,1425	AUA1	1437,1441	10-amino acid	AUA1	null	850537(Tax:4932)	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|END_ENTITY	Interestingly , a 10-amino_acid segment of AUA1 is directly repeated in the most basic segment of the protein .
8798639	8	10-amino_acid	1381,1394	beta2AR	1403,1410	10-amino acid	beta2AR	null	154	Chemical	Gene	region|amod|START_ENTITY region|dep|residues residues|amod|END_ENTITY	The results from more selective mutants -LRB- S - -LRB- 149-166 -RRB- , S - -LRB- 164-173 -RRB- , and S - -LRB- 149-158 -RRB- -RRB- indicated that a limited 10-amino_acid region -LRB- beta2AR residues 149-158 -RRB- , localized at the interface of the cytoplasm and the transmembrane domain , contains a critical determinant for exosite binding .
1849641	6	10-amino_acid	1235,1248	beta_2AR	1275,1283	10-amino acid	beta 2AR	null	154	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|domain domain|nmod|END_ENTITY	We replaced four serine and threonine residues located within a 10-amino_acid segment of this domain of beta_2AR and thereby prevented agonist-promoted phosphorylation , sequestration , and rapid desensitization of the adenylyl cyclase response .
8576242	9	10-amino_acid	1157,1170	Cdc2	1200,1204	10-amino acid	Cdc2	null	396252(Tax:9031)	Chemical	Gene	insert|amod|START_ENTITY HMMexp|nmod|insert phosphorylated|nsubjpass|HMMexp phosphorylated|nmod|END_ENTITY	HMMexp with the 10-amino_acid insert was phosphorylated by Cdc2 , Cdk5 , and mitogen-activated protein kinase in vitro to 0.3-0 .4 mol of PO4/mol of MHC .
8576242	9	10-amino_acid	1157,1170	Cdk5	1206,1210	10-amino acid	Cdk5	null	100190948(Tax:9031)	Chemical	Gene	insert|amod|START_ENTITY HMMexp|nmod|insert phosphorylated|nsubjpass|HMMexp phosphorylated|nmod|Cdc2 Cdc2|conj|END_ENTITY	HMMexp with the 10-amino_acid insert was phosphorylated by Cdc2 , Cdk5 , and mitogen-activated protein kinase in vitro to 0.3-0 .4 mol of PO4/mol of MHC .
9226470	3	10-amino_acid	427,440	c-Jun_aminoterminal_kinase	575,601	10-amino acid	c-Jun aminoterminal kinase	null	26419(Tax:10090)	Chemical	Gene	segment|amod|START_ENTITY rescue|nsubj|segment demonstrated|ccomp|rescue demonstrated|conj|involved involved|nmod|activation activation|nmod|END_ENTITY	We demonstrated that a 10-amino_acid segment in the conserved cytoplasmic region of CD40-mediated rescue from IgM-induced cell death and was involved in the activation of c-Jun_aminoterminal_kinase -LRB- JNK -RRB- .
17686645	5	10-amino_acid	782,795	DAX1	675,679	10-amino acid	DAX1	MESH:D000596	190	Chemical	Gene	motif|amod|START_ENTITY replaced|nmod|motif lacks|conj|replaced isoform|acl:relcl|lacks isoform|nmod|END_ENTITY	DAX1A is an alternatively spliced isoform of DAX1 that lacks the last 80 amino acids of the DAX1 C-terminal repressor domain and is replaced by a novel 10-amino_acid motif .
17686645	5	10-amino_acid	782,795	DAX1	722,726	10-amino acid	DAX1	MESH:D000596	190	Chemical	Gene	motif|amod|START_ENTITY replaced|nmod|motif lacks|conj|replaced lacks|dobj|acids acids|nmod|domain domain|compound|END_ENTITY	DAX1A is an alternatively spliced isoform of DAX1 that lacks the last 80 amino acids of the DAX1 C-terminal repressor domain and is replaced by a novel 10-amino_acid motif .
21266171	5	10-amino_acid	707,720	EAAT3	776,781	10-amino acid	EAAT3	MESH:D000596	6505	Chemical	Gene	peptide|amod|START_ENTITY conjugated|dobj|peptide conjugated|nmod|sequence sequence|amod|identical identical|nmod|that that|nmod|END_ENTITY	We conjugated a 10-amino_acid synthetic peptide with a sequence identical to that of EAAT3 around the S465 to a peptide that can facilitate permeation of the plasma membrane .
7720083	7	10-amino_acid	1526,1539	gp120	1591,1596	10-amino acid	gp120	MESH:D000596	155971(Tax:11676)	Chemical	Gene	peptide|amod|START_ENTITY peptide|nmod|region region|nmod|HIV-1 HIV-1|nummod|END_ENTITY	These results establish that a carrier-free 10-amino_acid synthetic peptide from the V3 loop region in HIV-1 gp120 has the optimal sequence for efficient induction of HIV env-specific CTLs in mice .
8034658	5	10-amino_acid	1000,1013	gp130	978,983	10-amino acid	gp130	null	3572	Chemical	Gene	TQPLLDSEER|amod|START_ENTITY crucial|nsubj|TQPLLDSEER revealed|ccomp|crucial revealed|nsubj|Mutants Mutants|nmod|truncations truncations|nmod|domain domain|nmod|END_ENTITY	Mutants with different truncations within the intracellular domain of gp130 revealed that a 10-amino_acid sequence TQPLLDSEER is crucial for efficient internalization .
8621406	2	10-amino_acid	374,387	gp130	443,448	10-amino acid	gp130	null	3572	Chemical	Gene	TQPLLDSEER|amod|START_ENTITY TQPLLDSEER|nmod|domain domain|nmod|END_ENTITY	Our previous studies revealed that the 10-amino_acid sequence TQPLLDSEER within the intracellular domain of gp130 is crucial for the efficient internalization of IL-6 .
18310283	2	10-amino_acid	344,357	GRP	377,380	10-amino acid	GRP	null	225642(Tax:10090)	Chemical	Gene	epitope|amod|START_ENTITY epitope|nmod|fragment fragment|compound|END_ENTITY	We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection .
2160654	2	10-amino_acid	470,483	GRP	484,487	10-amino acid	GRP	null	100728828	Chemical	Gene	peptide|amod|START_ENTITY peptide|compound|END_ENTITY	In extracts of myenteric plexus and gradients derived therefrom , the 10-amino_acid GRP peptide -LRB- GRP-10 -RRB- was the sole form present ; this was bimodally distributed in the gradients , one peak copurifying with Golgi membranes and apparently consisting of immature storage particles , the other with other synaptophysin-rich neuropeptide-containing particles .
12576325	8	10-amino_acid	1265,1278	HLA-A/B	1350,1357	10-amino acid	HLA-A/B	null	3105;3106	Chemical	Gene	haplotypes|amod|START_ENTITY haplotypes|amod|peptides peptides|conj|fitting fitting|nmod|END_ENTITY	There were 8 - to 10-amino_acid -LRB- aa -RRB- long peptides corresponding to the CDRs and fitting to the actual HLA-A/B haplotypes that spontaneously recognized , albeit with a low magnitude , type I T cells -LRB- interferon gamma -RRB- , indicating an ongoing major histocompatibility complex -LRB- MHC -RRB- class I-restricted T-cell response .
18310283	2	10-amino_acid	344,357	HSP65	287,292	10-amino acid	HSP65	null	15510(Tax:10090)	Chemical	Gene	epitope|amod|START_ENTITY copies|nmod|epitope consists|nmod|copies END_ENTITY|acl:relcl|consists	We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection .
18310283	2	10-amino_acid	344,357	HSP65	433,438	10-amino acid	HSP65	null	15510(Tax:10090)	Chemical	Gene	epitope|amod|START_ENTITY epitope|nmod|fragment fragment|acl|carried carried|nmod|END_ENTITY	We developed a novel protein vaccine HSP65 - -LRB- GRP-10 -RRB- -LRB- 6 -RRB- -LRB- HG6 -RRB- that consists of six copies of a 10-amino_acid residue epitope of GRP C-terminal fragment carried by mycobacterial 65 kDa HSP65 and then immunized mice via subcutaneous injection .
8621406	2	10-amino_acid	374,387	IL-6	497,501	10-amino acid	IL-6	null	3569	Chemical	Gene	TQPLLDSEER|amod|START_ENTITY crucial|nsubj|TQPLLDSEER crucial|nmod|internalization internalization|nmod|END_ENTITY	Our previous studies revealed that the 10-amino_acid sequence TQPLLDSEER within the intracellular domain of gp130 is crucial for the efficient internalization of IL-6 .
9226470	3	10-amino_acid	427,440	JNK	603,606	10-amino acid	JNK	null	26419(Tax:10090)	Chemical	Gene	segment|amod|START_ENTITY rescue|nsubj|segment demonstrated|ccomp|rescue demonstrated|conj|involved involved|nmod|activation activation|nmod|c-Jun_aminoterminal_kinase c-Jun_aminoterminal_kinase|appos|END_ENTITY	We demonstrated that a 10-amino_acid segment in the conserved cytoplasmic region of CD40-mediated rescue from IgM-induced cell death and was involved in the activation of c-Jun_aminoterminal_kinase -LRB- JNK -RRB- .
8464900	5	10-amino_acid	861,874	MHC-B	813,818	10-amino acid	MHC-B	null	397760(Tax:8355)	Chemical	Gene	insert|amod|START_ENTITY contain|dobj|insert contain|nsubj|fraction fraction|nmod|mRNA mRNA|acl|encoding encoding|dobj|isoform isoform|amod|END_ENTITY	In chickens and humans , a fraction of the mRNA encoding the MHC-B isoform was found previously to contain a 10-amino_acid insert at amino_acid 211 near the ATP-binding site .
11000493	6	10-amino_acid	959,972	NCAM	1013,1017	10-amino acid	NCAM	null	4684	Chemical	Gene	peptide|amod|START_ENTITY Using|dobj|peptide Using|nmod|domain domain|nmod|END_ENTITY	Using a 10-amino_acid peptide from the third Ig domain of the NCAM , a peptide fragment within the region recognized by the NCAM antibody , mimics the effect of the molecule in reducing NO production .
11000493	6	10-amino_acid	959,972	NCAM	1074,1078	10-amino acid	NCAM	null	4684	Chemical	Gene	peptide|amod|START_ENTITY Using|dobj|peptide fragment|dep|Using fragment|nmod|region region|acl|recognized recognized|nmod|antibody antibody|compound|END_ENTITY	Using a 10-amino_acid peptide from the third Ig domain of the NCAM , a peptide fragment within the region recognized by the NCAM antibody , mimics the effect of the molecule in reducing NO production .
9099756	4	10-amino_acid	748,761	OEP34	663,668	10-amino acid	OEP34	null	830382(Tax:3702)	Chemical	Gene	core|amod|START_ENTITY located|nmod|core show|ccomp|located show|advcl|Using Using|dobj|homologue homologue|nmod|END_ENTITY	Using an Arabidopsis homologue of the originally isolated pea OEP34 , we show that the outer membrane-targeting signal of OEP34 is located within a 10-amino_acid hydrophobic core of the C-terminal membrane anchor .
9099756	4	10-amino_acid	748,761	OEP34	722,727	10-amino acid	OEP34	null	830382(Tax:3702)	Chemical	Gene	core|amod|START_ENTITY located|nmod|core located|nsubjpass|signal signal|nmod|END_ENTITY	Using an Arabidopsis homologue of the originally isolated pea OEP34 , we show that the outer membrane-targeting signal of OEP34 is located within a 10-amino_acid hydrophobic core of the C-terminal membrane anchor .
18372524	2	10-amino_acid	186,199	ST3	270,273	10-amino acid	ST3	null	4320	Chemical	Gene	sandwiched|amod|START_ENTITY sandwiched|nmod|pro-domain pro-domain|conj|domain domain|nmod|END_ENTITY	In particular , an unusual 10-amino_acid residue sandwiched between the pro-domain and the catalytic domain of ST3 exists in ST3 but not in other matrix metalloproteinases -LRB- MMPs -RRB- .
18372524	2	10-amino_acid	186,199	ST3	284,287	10-amino acid	ST3	null	4320	Chemical	Gene	sandwiched|amod|START_ENTITY exists|nsubj|sandwiched exists|nmod|END_ENTITY	In particular , an unusual 10-amino_acid residue sandwiched between the pro-domain and the catalytic domain of ST3 exists in ST3 but not in other matrix metalloproteinases -LRB- MMPs -RRB- .
10670454	2	10-amino-acid	393,406	ADAR2	272,277	10-amino-acid	ADAR2	null	104	Chemical	Gene	insert|amod|START_ENTITY presence|nmod|insert differ|nmod|presence variants|acl:relcl|differ giving|nmod|variants undergoes|advcl|giving undergoes|nsubj|END_ENTITY	In rodents , ADAR2 undergoes alternative RNA splicing , giving rise to two splice variants that differ by the presence or absence of a 10-amino-acid insert in the carboxy-terminal catalytic domain .
1488105	1	10-amino-acid	109,122	bombesin	148,156	10-amino-acid	bombesin	null	2922	Chemical	Gene	peptide|amod|START_ENTITY peptide|nmod|family family|compound|END_ENTITY	Neuromedin_B is a 10-amino-acid mammalian peptide of the bombesin family .
9032281	7	10-amino-acid	828,841	CD30	884,888	10-amino-acid	CD30	null	943	Chemical	Gene	elements|amod|START_ENTITY elements|acl:relcl|mediate mediate|dobj|family family|amod|binding binding|nmod|END_ENTITY	Domain 2 contains two 5 - to 10-amino-acid elements which can mediate the binding of CD30 to members of the tumor necrosis factor receptor-associated factor -LRB- TRAF -RRB- family of signal transducing proteins .
9144420	0	10-amino-acid	24,37	CD40	75,79	10-amino-acid	CD40	null	958	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|region region|nmod|MAP MAP|amod|END_ENTITY	Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses .
18523634	5	10-amino-acid	955,968	CD8	1003,1006	10-amino-acid	CD8	null	925	Chemical	Gene	SALKLAIYKA|amod|START_ENTITY SALKLAIYKA|dep|% %|nmod|cells cells|compound|END_ENTITY	Using pools of overlapping peptides spanning the whole B19V proteome , strong CD8 -LRB- + -RRB- T-cell responses were elicited to the 10-amino-acid peptides SALKLAIYKA -LRB- 19.7 % of all CD8 -LRB- + -RRB- cells -RRB- and QSALKLAIYK -LRB- 10 % -RRB- and additional weaker responses to GLCPHCINVG -LRB- 0.71 % -RRB- and LLHTDFEQVM -LRB- 0.06 % -RRB- .
18523634	5	10-amino-acid	955,968	CD8	910,913	10-amino-acid	CD8	null	925	Chemical	Gene	SALKLAIYKA|amod|START_ENTITY elicited|nmod|SALKLAIYKA T-cell|ccomp|elicited T-cell|nsubj|END_ENTITY	Using pools of overlapping peptides spanning the whole B19V proteome , strong CD8 -LRB- + -RRB- T-cell responses were elicited to the 10-amino-acid peptides SALKLAIYKA -LRB- 19.7 % of all CD8 -LRB- + -RRB- cells -RRB- and QSALKLAIYK -LRB- 10 % -RRB- and additional weaker responses to GLCPHCINVG -LRB- 0.71 % -RRB- and LLHTDFEQVM -LRB- 0.06 % -RRB- .
2143919	2	10-amino-acid	262,275	CD8	227,230	10-amino-acid	CD8	null	925	Chemical	Gene	bearing|dep|START_ENTITY bearing|dobj|END_ENTITY	CTLs bearing the surface molecule CD8 recognize small -LRB- approximately 10-amino-acid -RRB- viral peptides that are presented in association with major histocompatibility -LRB- MHC -RRB- class I molecules at the surface of tumor cells .
7908700	6	10-amino-acid	1241,1254	CD8	1182,1185	10-amino-acid	CD8	null	925	Chemical	Gene	epitope|amod|START_ENTITY restricted|dobj|epitope HLA-A3|acl|restricted HLA-A3|nsubj|response response|compound|END_ENTITY	An immunodominant CD8 + CTL response was HLA-A3 .1 restricted and recognized a 10-amino-acid epitope -LRB- gp120/38 -47 -RRB- in a highly conserved region of gp120 .
20641585	14	10-amino-acid	2632,2645	CH1	2516,2519	10-amino-acid	CH1	null	51430	Chemical	Gene	spacer|amod|START_ENTITY addition|nmod|spacer followed|nmod|addition domain|acl|followed domain|compound|END_ENTITY	The light chain constant domain was a human Ck , and the human y1 chain was genetically modified to produce a heavy chain composed of a CH1 domain followed by a partial IgG1 hinge region tethered to the CH3 heavy chain domain by addition of a flexible 10-amino-acid GGGSSGGGSG spacer -LRB- 22 -RRB- .
25341359	2	10-amino-acid	374,387	c-Met	448,453	10-amino-acid	c-Met	null	4233	Chemical	Gene	spacer|amod|START_ENTITY separated|nmod|spacer residues|acl|separated located|nsubj|residues located|nmod|region region|nmod|function function|amod|END_ENTITY	Here , we report that two histidine residues separated by a 10-amino-acid spacer -LRB- H1068-H1079 -RRB- located in the juxtamembrane region of c-Met function as a putative novel NLS .
11683359	10	10-amino-acid	1036,1049	cysteine-rich_secretory_protein-1	1095,1128	10-amino-acid	cysteine-rich secretory protein-1	null	167	Chemical	Gene	sequence|amod|START_ENTITY showed|nsubj|sequence showed|dobj|similarity similarity|nmod|precursor precursor|amod|END_ENTITY	The first 10-amino-acid sequence showed 60-77 % similarity with human cysteine-rich_secretory_protein-1 precursor , inhibin alpha chain precursor .
7746327	4	10-amino-acid	791,804	furin	982,987	10-amino-acid	furin	null	5045	Chemical	Gene	insert|amod|START_ENTITY insert|acl:relcl|encrypted encrypted|nmod|motif motif|nmod|proteinase proteinase|appos|END_ENTITY	Intracellular activation is regulated by an unusual 10-amino-acid insert sandwiched between the pro- and catalytic-domains of stromelysin-3 , which is encrypted with an Arg-X-Arg-X-Lys-Arg recognition motif for the Golgi-associated proteinase , furin , a mammalian homologue of the yeast Kex2 pheromone convertase .
23159559	4	10-amino-acid	551,564	GLD-3	579,584	10-amino-acid	GLD-3	null	174174(Tax:6239)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	A 10-amino-acid region within GLD-3 is required for FBF binding , while a 7-amino-acid loop in FBF between PUF repeats 7 and 8 is necessary for GLD-3 binding .
23159559	4	10-amino-acid	551,564	GLD-3	692,697	10-amino-acid	GLD-3	null	174174(Tax:6239)	Chemical	Gene	region|amod|START_ENTITY required|nsubjpass|region required|advcl|repeats repeats|ccomp|necessary necessary|nmod|END_ENTITY	A 10-amino-acid region within GLD-3 is required for FBF binding , while a 7-amino-acid loop in FBF between PUF repeats 7 and 8 is necessary for GLD-3 binding .
12447356	1	10-amino-acid	283,296	GnRH-II	264,271	10-amino-acid	GnRH-II	null	2797	Chemical	Gene	neuropeptide|amod|START_ENTITY gonadotropin-releasing_hormone-II|appos|neuropeptide gonadotropin-releasing_hormone-II|appos|END_ENTITY	Can T cells be directly activated to de novo gene expression by gonadotropin-releasing_hormone-II -LRB- GnRH-II -RRB- , a unique 10-amino-acid neuropeptide conserved through 500 million years of evolution ?
12447356	1	10-amino-acid	283,296	gonadotropin-releasing_hormone-II	229,262	10-amino-acid	gonadotropin-releasing hormone-II	null	2797	Chemical	Gene	neuropeptide|amod|START_ENTITY END_ENTITY|appos|neuropeptide	Can T cells be directly activated to de novo gene expression by gonadotropin-releasing_hormone-II -LRB- GnRH-II -RRB- , a unique 10-amino-acid neuropeptide conserved through 500 million years of evolution ?
7908700	6	10-amino-acid	1241,1254	gp120	1309,1314	10-amino-acid	gp120	null	3700	Chemical	Gene	epitope|amod|START_ENTITY restricted|dobj|epitope restricted|nmod|region region|nmod|END_ENTITY	An immunodominant CD8 + CTL response was HLA-A3 .1 restricted and recognized a 10-amino-acid epitope -LRB- gp120/38 -47 -RRB- in a highly conserved region of gp120 .
1501277	2	10-amino-acid	510,523	HBc	476,479	10-amino-acid	HBc	null	85348	Chemical	Gene	portion|amod|START_ENTITY due|nmod|portion due|nsubj|properties properties|acl:relcl|distinguish distinguish|nmod|protein protein|compound|END_ENTITY	The data show that the properties which distinguish the HBe protein from the HBc protein are due mostly to the 10-amino-acid portion of the HBe leader sequence which remains attached to the HBe protein after cleavage .
12359743	6	10-amino-acid	939,952	KiSS1	858,863	10-amino-acid	KiSS1	null	280287(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY peptides|appos|residues conserved|nsubj|peptides conserved|advcl|share share|nsubj|proteins proteins|compound|END_ENTITY	Although human and mouse KiSS1 proteins share relatively low overall homology -LRB- 52 % -RRB- , the active peptides -LRB- 10-amino-acid residues -RRB- are highly conserved between mouse and human KiSS1 proteins , varying by only one conserved amino_acid -LSB- Tyr -LRB- Y -RRB- to Phe -LRB- F -RRB- -RSB- .
2722848	5	10-amino-acid	872,885	LDL_receptor	751,763	10-amino-acid	LDL receptor	null	3949	Chemical	Gene	linker|amod|START_ENTITY directed|nmod|linker shows|conj|directed shows|nsubj|END_ENTITY	Under these conditions , the human LDL_receptor shows high affinity for 125I-LDL and for 125I-IgG-HL1 , a monoclonal antipeptide antibody directed against a 10-amino-acid `` linker '' between repeats 4 and 5 in the ligand binding domain .
10873763	3	10-amino-acid	565,578	LMP1	537,541	10-amino-acid	LMP1	MESH:D000596	9260	Chemical	Gene	deletion|amod|START_ENTITY variants|nmod|deletion variants|nummod|END_ENTITY	The identification of LMP1 variants with a common 10-amino-acid deletion and additional point mutations -LRB- typified by the CAO-LMP1 isolate -RRB- in EBV strains associated with nasopharyngeal_carcinoma prompted us to examine the effect of stable prototype B95.8-LMP1 and CAO-LMP1 expression on the phenotype and differentiation of SCC12F human epithelial cells .
9557692	1	10-amino-acid	258,271	LMP1	349,353	10-amino-acid	LMP1	null	17494204	Chemical	Gene	deletion|amod|START_ENTITY characterized|nmod|deletion characterized|nmod|domain domain|nmod|protein protein|appos|END_ENTITY	One group of sequence variants of Epstein-Barr_virus is characterized by a 10-amino-acid deletion within the CTAR-2 functional domain of the latent membrane protein , LMP1 .
9407003	4	10-amino-acid	615,628	LMP_1	686,691	10-amino-acid	LMP 1	null	9260	Chemical	Gene	deletion|amod|START_ENTITY affected|nsubj|deletion affected|nmod|END_ENTITY	In this study , we tested if this 10-amino-acid deletion affected the induction of NF-kappaB activity by LMP_1 .
9858609	7	10-amino-acid	1420,1433	mdm2	1598,1602	10-amino-acid	mdm2	MESH:D000596	314856(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY important|nsubj|sequence important|nmod|activation activation|nmod|element element|amod|END_ENTITY	A 10-amino-acid sequence in the N-terminal region of T3Ralpha that is important for transactivation and interaction with TFIIB was also found to be important for activation of the mdm2 gene response element .
10627389	6	10-amino-acid	862,875	MIP-1_beta	888,898	10-amino-acid	MIP-1 beta	null	395551(Tax:9031)	Chemical	Gene	peptides|amod|START_ENTITY peptides|nmod|END_ENTITY	The chemotactic activity could be neutralized by antibodies prepared against two 10-amino-acid peptides of MIP-1_beta , indicating that the substance was MIP-1_beta .
10627389	6	10-amino-acid	862,875	MIP-1_beta	934,944	10-amino-acid	MIP-1 beta	null	395551(Tax:9031)	Chemical	Gene	peptides|amod|START_ENTITY prepared|nmod|peptides prepared|xcomp|indicating indicating|ccomp|END_ENTITY	The chemotactic activity could be neutralized by antibodies prepared against two 10-amino-acid peptides of MIP-1_beta , indicating that the substance was MIP-1_beta .
11082039	10	10-amino-acid	1550,1563	MRP1	1671,1675	10-amino-acid	MRP1	null	4363	Chemical	Gene	deletion|amod|START_ENTITY abolished|nsubj|deletion abolished|nmod|function function|compound|END_ENTITY	A 10-amino-acid deletion in a predicted amphipathic region of L -LRB- 0 -RRB- abolished its attachment to the membrane and eliminated MRP1 transport function , but did not affect membrane routing .
1488105	1	10-amino-acid	109,122	Neuromedin_B	91,103	10-amino-acid	Neuromedin B	null	4828	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY	Neuromedin_B is a 10-amino-acid mammalian peptide of the bombesin family .
9817857	1	10-amino-acid	267,280	OspC	293,297	10-amino-acid	OspC	null	13917590	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Sera from 210 patients with Lyme_borreliosis -LRB- LB -RRB- were studied by an enzyme-linked immunosorbent assay -LRB- ELISA -RRB- based on a synthetic peptide -LRB- pepC10 -RRB- comprising the C-terminal 10-amino-acid residues of OspC of Borrelia_burgdorferi .
1448076	6	10-amino-acid	912,925	p59fyn	889,895	10-amino-acid	p59fyn	null	2534	Chemical	Gene	sequence|amod|START_ENTITY responsible|nsubj|sequence revealed|ccomp|responsible revealed|nsubj|analysis analysis|nmod|END_ENTITY	Mutational analysis of p59fyn revealed that a 10-amino-acid sequence in the unique amino-terminal domain of p59fyn was responsible for the association with zeta .
1448076	6	10-amino-acid	912,925	p59fyn	974,980	10-amino-acid	p59fyn	null	2534	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY	Mutational analysis of p59fyn revealed that a 10-amino-acid sequence in the unique amino-terminal domain of p59fyn was responsible for the association with zeta .
8635515	6	10-amino-acid	634,647	RAR_alpha	613,622	10-amino-acid	RAR alpha	null	19401(Tax:10090)	Chemical	Gene	insert|amod|START_ENTITY carrying|dobj|insert END_ENTITY|acl|carrying	A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain .
8635515	6	10-amino-acid	634,647	RAR_alpha	714,723	10-amino-acid	RAR alpha	null	19401(Tax:10090)	Chemical	Gene	insert|amod|START_ENTITY carrying|dobj|insert RAR_alpha|acl|carrying mutant|nmod|RAR_alpha heterodimerize|nsubj|mutant heterodimerize|nmod|RXRbeta RXRbeta|conj|END_ENTITY	A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain .
8635515	6	10-amino-acid	634,647	RXRbeta	687,694	10-amino-acid	RXRbeta	null	20182(Tax:10090)	Chemical	Gene	insert|amod|START_ENTITY carrying|dobj|insert RAR_alpha|acl|carrying mutant|nmod|RAR_alpha heterodimerize|nsubj|mutant heterodimerize|nmod|END_ENTITY	A mutant of RAR_alpha carrying a 10-amino-acid insert was able to heterodimerize with RXRbeta or with the normal RAR_alpha and the inhibitory activity of this mutant was dependent on an intact DNA binding domain .
12231168	3	10-amino-acid	707,720	SERPINA1	672,680	10-amino-acid	SERPINA1	null	5265	Chemical	Gene	tag|dep|START_ENTITY tagged|nmod|tag gene|acl|tagged gene|compound|END_ENTITY	Subsequent studies made use of the baboon SERPINA1 gene tagged with a short -LRB- 10-amino-acid -RRB- c-myc tag .
9271397	7	10-amino-acid	1464,1477	Sp1	1513,1516	10-amino-acid	Sp1	null	31913(Tax:7227)	Chemical	Gene	stretch|amod|START_ENTITY stretch|acl:relcl|present present|nmod|members members|amod|END_ENTITY	This crucial domain encompasses the buttonhead box , which is a 10-amino-acid stretch that is present in several Sp1 family members , including the Drosophila buttonhead gene product .
7746327	4	10-amino-acid	791,804	stromelysin-3	865,878	10-amino-acid	stromelysin-3	null	4320	Chemical	Gene	insert|amod|START_ENTITY insert|nmod|pro- pro-|nmod|END_ENTITY	Intracellular activation is regulated by an unusual 10-amino-acid insert sandwiched between the pro- and catalytic-domains of stromelysin-3 , which is encrypted with an Arg-X-Arg-X-Lys-Arg recognition motif for the Golgi-associated proteinase , furin , a mammalian homologue of the yeast Kex2 pheromone convertase .
7623841	0	10-amino-acid	2,15	thyroid_hormone_receptor_alpha	57,87	10-amino-acid	thyroid hormone receptor alpha	null	396251(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY	A 10-amino-acid sequence in the N-terminal A/B domain of thyroid_hormone_receptor_alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB .
21507971	4	10-amino-acid	832,845	Vpx	759,762	10-amino-acid	Vpx	null	1490006(Tax:11723)	Chemical	Gene	motif|amod|START_ENTITY localized|nmod|motif localized|dobj|motif motif|compound|END_ENTITY	We localized the minimal Vpx packaging motif of simian_immunodeficiency_virus SIVmac -LRB- 239 -RRB- p6 to a 10-amino-acid motif and introduced this sequence into an infectious_HIV-1 provirus .
21651901	1	10-amino_acid_peptide	142,163	PTD	314,317	10-amino acid peptide	PTD	null	617	Chemical	Gene	derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|nmod|domain domain|appos|END_ENTITY	Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- .
21440624	2	10-amino_acid_peptide	328,349	TCTP	446,450	10-amino acid peptide	TCTP	null	7178	Chemical	Gene	derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|appos|END_ENTITY	We previously reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a PTD .
21651901	1	10-amino_acid_peptide	142,163	TCTP	264,268	10-amino acid peptide	TCTP	null	7178	Chemical	Gene	derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|appos|END_ENTITY	Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- .
21440624	2	10-amino_acid_peptide	328,349	translationally_controlled_tumor_protein	404,444	10-amino acid peptide	translationally controlled tumor protein	null	7178	Chemical	Gene	derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|compound|END_ENTITY	We previously reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a PTD .
21651901	1	10-amino_acid_peptide	142,163	translationally_controlled_tumor_protein	222,262	10-amino acid peptide	translationally controlled tumor protein	null	7178	Chemical	Gene	derived|nsubj|START_ENTITY derived|nmod|NH NH|dep|terminus terminus|nmod|functions functions|compound|END_ENTITY	Previously , we have reported that a 10-amino_acid_peptide -LRB- MIIYRDLISH -RRB- derived from the NH -LRB- 2 -RRB- - terminus of the human translationally_controlled_tumor_protein -LRB- TCTP -RRB- functions as a protein transduction domain -LRB- PTD -RRB- .
10482456	3	10-aminobenzoindolizidines	476,502	acetylcholinesterase	396,416	10-aminobenzoindolizidines	acetylcholinesterase	null	43	Chemical	Gene	11-aminobenzoquinolizidines|conj|START_ENTITY employing|xcomp|11-aminobenzoquinolizidines produce|advcl|employing produce|dobj|inhibitor inhibitor|amod|END_ENTITY	The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines -LRB- 4 -RRB- and 10-aminobenzoindolizidines -LRB- 5 -RRB- as templates .
16001167	11	10-amino-CPT	1398,1410	BCRP	1731,1735	10-amino-CPT	BCRP	MESH:C106646	9429	Chemical	Gene	uptake|nmod|START_ENTITY cells|appos|uptake increased|nsubj|cells indicated|parataxis|increased indicated|ccomp|changed changed|nmod|down-regulation down-regulation|nmod|breast_cancer_resistance_protein breast_cancer_resistance_protein|appos|END_ENTITY	In MCF-7 / wt cells , uptake of 10-amino-CPT increased 4-fold , while retention increased over 10-fold at acidic extracellular pH. In addition , gene expression analysis of MCF-7 / wt cells indicated that expression of a number of genes changed under acidic culture conditions , including down-regulation of the CPT efflux protein pump breast_cancer_resistance_protein -LRB- BCRP -RRB- .
16001167	11	10-amino-CPT	1398,1410	breast_cancer_resistance_protein	1697,1729	10-amino-CPT	breast cancer resistance protein	MESH:C106646	9429	Chemical	Gene	uptake|nmod|START_ENTITY cells|appos|uptake increased|nsubj|cells indicated|parataxis|increased indicated|ccomp|changed changed|nmod|down-regulation down-regulation|nmod|END_ENTITY	In MCF-7 / wt cells , uptake of 10-amino-CPT increased 4-fold , while retention increased over 10-fold at acidic extracellular pH. In addition , gene expression analysis of MCF-7 / wt cells indicated that expression of a number of genes changed under acidic culture conditions , including down-regulation of the CPT efflux protein pump breast_cancer_resistance_protein -LRB- BCRP -RRB- .
16272718	3	10-amino-goniothalamin	454,476	vp-16	636,641	10-amino-goniothalamin	vp-16	null	3054	Chemical	Gene	10-nitro-goniothalamin|conj|START_ENTITY derivatives|amod|10-nitro-goniothalamin gave|nsubj|derivatives gave|advcl|microg/ml microg/ml|nsubj|that that|nmod|etoposide etoposide|dep|END_ENTITY	The derivatives 10-nitro-goniothalamin and 10-amino-goniothalamin gave selective inhibition concentration -LRB- IC50 -RRB- of 1.10 and 1.14 microg/ml , respectively , against human stomach_cancer SGC-7901 cells , while that of etoposide -LRB- vp-16 -RRB- as the positive control was 6.07 microg/ml .
15998636	5	10_Arg-Gly-Gly	872,886	Npl3	838,842	10 Arg-Gly-Gly	Npl3	null	852042(Tax:4932)	Chemical	Gene	tripeptides|amod|START_ENTITY dimethylated|nsubjpass|tripeptides purified|advcl|dimethylated END_ENTITY|acl|purified	Matrix-assisted laser desorption/ionization Fourier transform mass spectrometry was used to identify 17 methylated arginines in Npl3 purified from yeast : whereas 10_Arg-Gly-Gly -LRB- RGG -RRB- tripeptides were exclusively dimethylated , variable levels of methylation were found for 5 RGG and 2 RG motif arginines .
8691487	0	10-arylisoalloxazines	45,66	glutathione_reductase	20,41	10-arylisoalloxazines	glutathione reductase	null	2936	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Inhibition of human glutathione_reductase by 10-arylisoalloxazines : crystalline , kinetic , and electrochemical studies .
14729370	1	10-azaBaP	158,167	BaP	189,192	10-azaBaP	BaP	null	11331	Chemical	Gene	pyrene|dep|START_ENTITY -LSB-|dep|pyrene -LSB-|appos|10-aza-analog 10-aza-analog|nmod|END_ENTITY	We previously reported that 10-azabenzo -LSB- a -RSB- pyrene -LRB- 10-azaBaP -RRB- , a 10-aza-analog of BaP and an environmental carcinogen , showed greater mutagenicity than BaP in the Ames test using pooled human liver S9 .
14729370	1	10-azaBaP	158,167	BaP	259,262	10-azaBaP	BaP	null	11331	Chemical	Gene	pyrene|dep|START_ENTITY -LSB-|dep|pyrene showed|nsubj|-LSB- showed|nmod|END_ENTITY	We previously reported that 10-azabenzo -LSB- a -RSB- pyrene -LRB- 10-azaBaP -RRB- , a 10-aza-analog of BaP and an environmental carcinogen , showed greater mutagenicity than BaP in the Ames test using pooled human liver S9 .
14729370	5	10-azaBaP	1029,1038	CYP1A1	1076,1082	10-azaBaP	CYP1A1	null	1543	Chemical	Gene	mutagenicity|nmod|START_ENTITY contributed|nmod|mutagenicity contributed|nmod|END_ENTITY	Moreover , recombinant human CYP1A2 contributed to the mutagenicity of 10-azaBaP more markedly than recombinant human CYP1A1 .
14729370	5	10-azaBaP	1029,1038	CYP1A2	987,993	10-azaBaP	CYP1A2	null	1544	Chemical	Gene	mutagenicity|nmod|START_ENTITY contributed|nmod|mutagenicity contributed|nsubj|END_ENTITY	Moreover , recombinant human CYP1A2 contributed to the mutagenicity of 10-azaBaP more markedly than recombinant human CYP1A1 .
14729370	6	10-azaBaP	1190,1199	CYP1A2	1111,1117	10-azaBaP	CYP1A2	null	1544	Chemical	Gene	activation|nmod|START_ENTITY responsible|nmod|activation enzyme|amod|responsible enzyme|nsubj|END_ENTITY	These results suggest that CYP1A2 may be the principal enzyme responsible for the metabolic activation of 10-azaBaP in human liver microsomes .
6384085	7	10-aza-glycine	1083,1097	LH-RH	1099,1104	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nsubj|-RSB-	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	7	10-aza-glycine	1083,1097	LH-RH	1175,1180	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|ccomp|40 40|nsubj|END_ENTITY	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	7	10-aza-glycine	1083,1097	LH-RH	1210,1215	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|ccomp|40 40|nmod|END_ENTITY	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	7	10-aza-glycine	1159,1173	LH-RH	1099,1104	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	LH-RH|amod|START_ENTITY 40|nsubj|LH-RH END_ENTITY|ccomp|40	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	7	10-aza-glycine	1159,1173	LH-RH	1175,1180	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	7	10-aza-glycine	1159,1173	LH-RH	1210,1215	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	LH-RH|amod|START_ENTITY 40|nsubj|LH-RH 40|nmod|END_ENTITY	The potencies of -LSB- 6 - -LRB- 3-benzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH and -LSB- 6 - -LRB- 3 - -LRB- 5,6-dimethylbenzimidazol-2-yl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH are 40 and 190 times that of LH-RH respectively .
6384085	8	10-aza-glycine	1304,1318	LH-RH	1320,1325	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nsubj|-RSB-	The most active compound in this series is -LSB- 6 - -LRB- 3 - -LRB- 2-naphthyl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH with a potency 230 times that of LH-RH .
6384085	8	10-aza-glycine	1304,1318	LH-RH	1359,1364	10-aza-glycine	LH-RH	null	25194(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY LH-RH|nsubj|-RSB- LH-RH|dobj|that that|nmod|END_ENTITY	The most active compound in this series is -LSB- 6 - -LRB- 3 - -LRB- 2-naphthyl -RRB- - D-alanine -RRB- , 10-aza-glycine -RSB- LH-RH with a potency 230 times that of LH-RH .
22239252	4	10-azidodecanoic_acid	707,728	LAP	732,735	10-azidodecanoic acid	LAP	null	7939	Chemical	Gene	START_ENTITY|advcl|END_ENTITY	First , we found that the W37I mutant of LplA catalyzes site-specific ligation of 10-azidodecanoic_acid to LAP in cells , in nearly quantitative yield after 30 min .
2879826	2	10_BA	308,313	C-2	340,343	10 BA	C-2	null	24231(Tax:10116)	Chemical	Gene	derivatives|nummod|START_ENTITY supported|nmod|derivatives supported|advmod|efficiently efficiently|nmod:npmod|compounds compounds|dep|END_ENTITY	Of the 10_BA derivatives , 7 compounds -LRB- C-2 , 3 , 4 , 5 , 6 , 9 , and 10 -RRB- efficiently supported hepatocyte survival for at least 2 wks in primary culture .
9877098	7	10B-BPA	1462,1469	TA1059	1423,1429	10B-BPA	TA1059	null	1456575(Tax:273075)	Chemical	Gene	BNCT|nummod|START_ENTITY as|nmod:npmod|BNCT suppressed|advcl|as suppressed|nsubjpass|growth growth|nmod|END_ENTITY	In animal experiments , by using these cell lines , tumor growth of TA1059 was significantly suppressed by 10B-BPA BNCT as compared with A1059 .
23939374	7	10-benzylidene-10H-anthracen-9-one	1190,1224	androgen_receptor	1350,1367	10-benzylidene-10H-anthracen-9-one	androgen receptor	null	367	Chemical	Gene	analogues|amod|START_ENTITY identified|nmod|analogues identified|ccomp|showed showed|conj|inhibited inhibited|dobj|activity activity|amod|END_ENTITY	Of these 10-benzylidene-10H-anthracen-9-one analogues , a lead compound -LRB- VPC-3033 -RRB- was identified that showed strong androgen displacement potency , effectively inhibited androgen_receptor transcriptional activity , and possesses a profound ability to cause degradation of androgen_receptor .
23939374	7	10-benzylidene-10H-anthracen-9-one	1190,1224	androgen_receptor	1451,1468	10-benzylidene-10H-anthracen-9-one	androgen receptor	null	367	Chemical	Gene	analogues|amod|START_ENTITY identified|nmod|analogues identified|ccomp|showed showed|conj|possesses possesses|dobj|ability ability|acl|cause cause|dobj|degradation degradation|nmod|END_ENTITY	Of these 10-benzylidene-10H-anthracen-9-one analogues , a lead compound -LRB- VPC-3033 -RRB- was identified that showed strong androgen displacement potency , effectively inhibited androgen_receptor transcriptional activity , and possesses a profound ability to cause degradation of androgen_receptor .
23939374	6	10-benzylidene-10H-anthracen-9-ones	997,1032	androgen_receptor	1067,1084	10-benzylidene-10H-anthracen-9-ones	androgen receptor	null	367	Chemical	Gene	number|nmod|START_ENTITY number|acl:relcl|inhibit inhibit|dobj|activity activity|amod|END_ENTITY	In this study , we implemented and used the synergetic combination of virtual and experimental screening to discover a number of new 10-benzylidene-10H-anthracen-9-ones that not only effectively inhibit androgen_receptor transcriptional activity , but also induce almost complete degradation of the androgen_receptor .
23939374	6	10-benzylidene-10H-anthracen-9-ones	997,1032	androgen_receptor	1162,1179	10-benzylidene-10H-anthracen-9-ones	androgen receptor	null	367	Chemical	Gene	number|nmod|START_ENTITY discover|dobj|number discover|conj|induce induce|dobj|degradation degradation|nmod|END_ENTITY	In this study , we implemented and used the synergetic combination of virtual and experimental screening to discover a number of new 10-benzylidene-10H-anthracen-9-ones that not only effectively inhibit androgen_receptor transcriptional activity , but also induce almost complete degradation of the androgen_receptor .
1123034	3	10-beta-cyanoethyl	430,448	VIII	455,459	10-beta-cyanoethyl	VIII	null	1351	Chemical	Gene	START_ENTITY|dep|VII VII|dep|END_ENTITY	10-Acyl -LRB- III - VI -RRB- and 10-beta-cyanoethyl -LRB- VII , VIII -RRB- derivatives of compounds -LRB- I -RRB- and -LRB- II -RRB- were easy obtained in good yield .
25175223	2	10Br-b-CD	503,512	b-CD	456,460	10Br-b-CD	b-CD	null	285440	Chemical	Gene	using|dobj|START_ENTITY introduced|xcomp|using introduced|nmod|surface surface|nmod|END_ENTITY	In order to reduce the cytotoxicity of the CD-PAM-b-PMeDMA , biocompatible polyacrylamide -LRB- PAM -RRB- was first introduced onto the surface of b-CD as a scaffold structure by ATRP using the 10Br-b-CD as a macroinitiator .
3088340	1	10-Butyryl	102,112	lipoxygenase-1	178,192	10-Butyryl	lipoxygenase-1	null	547923(Tax:3847)	Chemical	Gene	1,8-dihydroxyanthrone|amod|START_ENTITY inhibited|nsubj|1,8-dihydroxyanthrone inhibited|dobj|soybean soybean|amod|END_ENTITY	10-Butyryl substituted 1,8-dihydroxyanthrone -LRB- butantrone -RRB- inhibited soybean lipoxygenase-1 irreversibly and more efficiently than its parent compound 1,8-dihydroxyanthrone -LRB- dithranol , anthralin -RRB- -LRB- IC50 values 0.090 mM and 1.1 mM , respectively -RRB- .
2209005	1	10-butyryl_dithranol	170,190	MEST	327,331	10-butyryl dithranol	MEST	MESH:C038464	17294(Tax:10090)	Chemical	Gene	activity|dep|START_ENTITY studied|nsubjpass|activity studied|nmod|models models|dep|test test|conj|mouse_ear_swelling_test mouse_ear_swelling_test|appos|END_ENTITY	The contact sensitizing activity of dithranol and butantrone -LRB- 10-butyryl_dithranol -RRB- was studied in 3 animal models : the guinea_pig maximization test -LRB- GPMT -RRB- , the closed patch test -LRB- CPT -RRB- , and the mouse_ear_swelling_test -LRB- MEST -RRB- in 2 different mouse strains .
12151103	3	10_C2H2	456,463	ZNF333	432,438	10 C2H2	ZNF333	null	84449	Chemical	Gene	motifs|nummod|START_ENTITY contains|dobj|motifs contains|nsubj|END_ENTITY	ZNF333 further contains 10_C2H2 zinc finger motifs at the C-terminus .
20724647	2	10-carbon_dicarboxylic_acid	287,314	C10	316,319	10-carbon dicarboxylic acid	C10	null	3226	Chemical	Gene	START_ENTITY|dep|END_ENTITY	We aimed to evaluate the effect of sebacic_acid -LRB- a 10-carbon_dicarboxylic_acid ; C10 -RRB- ingestion on postprandial glycemia and glucose rate of appearance -LRB- Ra -RRB- in healthy and type 2 diabetic subjects .
22039047	0	10-carbon_fatty_acid	32,52	peroxisome_proliferator-activated_receptors	77,120	10-carbon fatty acid	peroxisome proliferator-activated receptors	MESH:D002244	19013(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY	Identification and mechanism of 10-carbon_fatty_acid as modulating ligand of peroxisome_proliferator-activated_receptors .
16126183	0	10-carbon_sugar	43,58	MSn	98,101	10-carbon sugar	MSn	null	4478	Chemical	Gene	derivatives|amod|START_ENTITY series|nmod|derivatives characterization|nmod|series characterization|nmod|spectrometry spectrometry|compound|END_ENTITY	Structural characterization of a series of 10-carbon_sugar derivatives by electrospray-ionization MSn mass spectrometry .
2417572	1	10-carboxymethyl-9-acridanone	169,198	CMA	202,205	10-carboxymethyl-9-acridanone	CMA	MESH:C026430	12761(Tax:10090)	Chemical	Gene	START_ENTITY|conj|END_ENTITY	9-oxo-10-acridineacetic_acid bearing the common name of 10-carboxymethyl-9-acridanone or CMA -LRB- 6 -RRB- was found to be a very potent interferon -LRB- IFN -RRB- inducer in adult Balb/c mice .
3081999	1	10-carboxymethyl-9-acridanone	294,323	IFN-alpha	237,246	10-carboxymethyl-9-acridanone	IFN-alpha	MESH:C026430	111654(Tax:10090)	Chemical	Gene	inducers|nmod|START_ENTITY used|nsubjpass|inducers produce|advcl|used produce|dobj|END_ENTITY	Besides the established T-cell property of producing gamma_interferon _ -LRB- IFN-gamma -RRB- , murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone -LRB- CMA -RRB- or Newcastle_disease virus -LRB- NDV -RRB- are used .
6181145	5	10-carboxymethyl-9-acridanone	827,856	IFN-alpha/beta	735,749	10-carboxymethyl-9-acridanone	IFN-alpha/beta	MESH:C026430	15977(Tax:10090)	Chemical	Gene	virus_type_IFN|amod|START_ENTITY virus_type_IFN|appos|END_ENTITY	When virus_type_IFN -LRB- IFN-alpha/beta -RRB- inducers , Newcastle_disease_virus , polyriboinosinic-polyribocytidylic_acid , 10-carboxymethyl-9-acridanone , and E. _ coli endotoxin , were administered to mice , no change in IFN response was observed after thermal_injury .
2596029	4	10-carboxymethyl-9-acridanone	748,777	IFN_beta	855,863	10-carboxymethyl-9-acridanone	IFN beta	MESH:C026430	15977(Tax:10090)	Chemical	Gene	macrophages|nmod|START_ENTITY Induction|nmod|macrophages resulted|nsubj|Induction resulted|conj|100-fold 100-fold|nsubj|mRNAs mRNAs|conj|level level|compound|END_ENTITY	Induction of macrophages with the synthetic inducer 10-carboxymethyl-9-acridanone resulted in small amounts of IFN_alpha 2 , alpha_4 , and alpha 6 mRNAs and the IFN_beta mRNA level was about 100-fold higher .
3081999	1	10-carboxymethyl-9-acridanone	294,323	IFN-beta	251,259	10-carboxymethyl-9-acridanone	IFN-beta	MESH:C026430	15977(Tax:10090)	Chemical	Gene	inducers|nmod|START_ENTITY used|nsubjpass|inducers produce|advcl|used produce|dobj|IFN-alpha IFN-alpha|conj|END_ENTITY	Besides the established T-cell property of producing gamma_interferon _ -LRB- IFN-gamma -RRB- , murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone -LRB- CMA -RRB- or Newcastle_disease virus -LRB- NDV -RRB- are used .
3081999	0	10-carboxymethyl-9-acridanone	64,93	interferon-beta	14,29	10-carboxymethyl-9-acridanone	interferon-beta	MESH:C026430	15977(Tax:10090)	Chemical	Gene	induced|advcl|START_ENTITY induced|nsubj|Production Production|nmod|END_ENTITY	Production of interferon-beta by murine T-cell lines induced by 10-carboxymethyl-9-acridanone .
28769808	1	10-Chloromethyl-11-demethyl-12-oxo-calanolide	88,133	F18	135,138	10-Chloromethyl-11-demethyl-12-oxo-calanolide	F18	null	10046	Chemical	Gene	START_ENTITY|appos|END_ENTITY	10-Chloromethyl-11-demethyl-12-oxo-calanolide -LRB- F18 -RRB- , an analog of calanolide_A , is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1 .
22037848	2	10-chloromethyl-11-demethyl-12-oxo-calanolide_A	444,491	F18	493,496	10-chloromethyl-11-demethyl-12-oxo-calanolide A	F18	MESH:C547679	10046	Chemical	Gene	START_ENTITY|appos|END_ENTITY	We previously described a newly synthesized small molecule , 10-chloromethyl-11-demethyl-12-oxo-calanolide_A -LRB- F18 -RRB- , a -LRB- + -RRB- - calanolide_A analog , as a novel anti-HIV-1 NNRTI -LRB- H. Xue et al. , J. Med .
7104299	1	10-CHO-H4folate	406,421	AICAR	297,302	10-CHO-H4folate	AICAR	null	471	Chemical	Gene	donor|dep|START_ENTITY mechanism|nmod|donor purine|nmod|mechanism purine|dobj|proceeds proceeds|amod|catalyzed catalyzed|nmod|transformylase transformylase|conj|transformylase transformylase|appos|END_ENTITY	It is shown that the transfer of formyl units in the de novo purine biosynthetic pathway as catalyzed by glycinamide_ribonucleotide -LRB- GAR -RRB- transformylase and 5-aminoimidazole-4-carboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase probably proceeds through a direct displacement mechanism involving only formyl donor -LRB- 10-CHO-H4folate -RRB- and formyl acceptor -LRB- GAR or AICAR -RRB- .
7104299	1	10-CHO-H4folate	406,421	AICAR	451,456	10-CHO-H4folate	AICAR	null	471	Chemical	Gene	donor|dep|START_ENTITY donor|appos|GAR GAR|conj|END_ENTITY	It is shown that the transfer of formyl units in the de novo purine biosynthetic pathway as catalyzed by glycinamide_ribonucleotide -LRB- GAR -RRB- transformylase and 5-aminoimidazole-4-carboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase probably proceeds through a direct displacement mechanism involving only formyl donor -LRB- 10-CHO-H4folate -RRB- and formyl acceptor -LRB- GAR or AICAR -RRB- .
11383691	2	10-cis-heptadecenoic_acid	448,473	ALC	436,439	10-cis-heptadecenoic acid	ALC	null	55821	Chemical	Gene	incubated|nsubjpass|START_ENTITY and/or|acl:relcl|incubated and/or|appos|17:0 17:0|dep|END_ENTITY	n-Heptadecanol -LRB- 17:0 - ALC -RRB- and/or 10-cis-heptadecenoic_acid -LRB- 17:1 - ACID -RRB- was incubated with liver homogenate of the six myctophid fishes and with co-factors such as NADPH and ATP for 2 to 5 h. Considerable amounts of wax esters with odd-numbered fatty_acids and/or alcohols were produced in the liver homogenate of the wax ester-rich species .
24586378	4	10-Cl-BBQ	866,875	AhR	889,892	10-Cl-BBQ	AhR	null	11622(Tax:10090)	Chemical	Gene	Iso-quinolin-7-one|dep|START_ENTITY Iso-quinolin-7-one|dep|ligand ligand|nsubj|END_ENTITY	We screened a ChemBridge small molecule library and identified 10-chloro-7H-benzimidazo -LSB- 2,1-a -RSB- benzo -LSB- de -RSB- Iso-quinolin-7-one -LRB- 10-Cl-BBQ -RRB- as a potent AhR ligand that was rapidly metabolized and not cytotoxic to proliferating T cells .
26573835	2	10-Cl-BBQ	517,526	AhR	550,553	10-Cl-BBQ	AhR	MESH:C000593972	11622(Tax:10090)	Chemical	Gene	iso-quinolin-7-one|dep|START_ENTITY discovered|xcomp|iso-quinolin-7-one discovered|xcomp|ligand ligand|dep|END_ENTITY	We recently discovered 10-chloro-7H-benzimidazo -LSB- 2,1-a -RSB- benzo -LSB- de -RSB- iso-quinolin-7-one -LRB- 10-Cl-BBQ -RRB- , a nanomolar affinity AhR ligand with immunosuppressive activity and favorable pharmacologic properties .
26573835	9	10-Cl-BBQ	1621,1630	AhR	1657,1660	10-Cl-BBQ	AhR	MESH:C000593972	11622(Tax:10090)	Chemical	Gene	END_ENTITY|nsubj|START_ENTITY	Taken together , 10-Cl-BBQ is an effective , nontoxic AhR ligand for the intervention of immune-mediated diseases that functions independently of Foxp3 -LRB- + -RRB- Tregs to suppress pathogenic T cell development .
26573835	0	10-Cl-BBQ	47,56	Aryl_Hydrocarbon_Receptor	18,43	10-Cl-BBQ	Aryl Hydrocarbon Receptor	MESH:C000593972	11622(Tax:10090)	Chemical	Gene	Insulitis|amod|START_ENTITY END_ENTITY|nmod|Insulitis	Activation of the Aryl_Hydrocarbon_Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3 + Regulatory T Cells in Nonobese Diabetic Mice .
26573835	0	10-Cl-BBQ	47,56	Foxp3	125,130	10-Cl-BBQ	Foxp3	MESH:C000593972	20371(Tax:10090)	Chemical	Gene	Insulitis|amod|START_ENTITY Insulitis|nmod|END_ENTITY	Activation of the Aryl_Hydrocarbon_Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3 + Regulatory T Cells in Nonobese Diabetic Mice .
26573835	9	10-Cl-BBQ	1621,1630	Foxp3	1749,1754	10-Cl-BBQ	Foxp3	MESH:C000593972	20371(Tax:10090)	Chemical	Gene	AhR|nsubj|START_ENTITY AhR|acl|ligand ligand|ccomp|Tregs Tregs|nsubj|functions functions|nmod|END_ENTITY	Taken together , 10-Cl-BBQ is an effective , nontoxic AhR ligand for the intervention of immune-mediated diseases that functions independently of Foxp3 -LRB- + -RRB- Tregs to suppress pathogenic T cell development .
11670058	7	10-Cl-XCbl	2951,2961	C10	2900,2903	10-Cl-XCbl	C10	null	113246	Chemical	Gene	complexes|amod|START_ENTITY spectrum|nmod|complexes causes|nmod|spectrum causes|nsubj|Substitution Substitution|nmod|H H|nmod|Cl Cl|nmod|END_ENTITY	Substitution of H by Cl at C10 causes the bands in the electronic spectrum of 10-Cl-XCbl complexes to move to lower energy , which is consistent with an increase in electron density in the corrin pi-conjugated system .
1399963	2	10-cmH2O	514,522	CO2	466,469	10-cmH2O	CO2	null	717	Chemical	Gene	breathing|conj|START_ENTITY rebreathing|nmod|breathing studied|xcomp|rebreathing studied|nmod|END_ENTITY	We studied 12 normal men during CO2 rebreathing while free breathing and with a 10-cmH2O .
18346930	4	10CpG	738,743	MAT1A	757,762	10CpG	MAT1A	null	11720(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|region region|compound|END_ENTITY	Bisulfite genomic sequencing indicated that the methylation status of 10CpG sites in the MAT1A promoter proximal region was appreciably correlated with the gene expression in mouse developing liver and in adult hepatic cells ; hepatic stellate cells and hepatocytes .
5879171	2	10-Cyanosteroids	36,52	C-3	71,74	10-Cyanosteroids	C-3	null	718	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	10-Cyanosteroids with an oxygen at C-3 .
11279126	2	10-cysteine	417,428	follistatin	320,331	10-cysteine	follistatin	null	100774874	Chemical	Gene	domains|amod|START_ENTITY repeating|dobj|domains followed|xcomp|repeating segment|acl|followed comprised|nmod|segment comprised|nsubjpass|molecule molecule|compound|END_ENTITY	The 288-residue follistatin molecule is comprised of a 63-residue N-terminal segment followed by three repeating 10-cysteine `` follistatin domains '' also represented in several extracellular matrix proteins .
11279126	2	10-cysteine	417,428	follistatin	430,441	10-cysteine	follistatin	null	100774874	Chemical	Gene	domains|amod|START_ENTITY domains|amod|END_ENTITY	The 288-residue follistatin molecule is comprised of a 63-residue N-terminal segment followed by three repeating 10-cysteine `` follistatin domains '' also represented in several extracellular matrix proteins .
12595574	5	10-cysteine	921,932	follistatin	949,960	10-cysteine	follistatin	null	14313(Tax:10090)	Chemical	Gene	repeat|amod|START_ENTITY repeat|acl|found found|nmod|END_ENTITY	GASP-1 also contains a domain homologous to the 10-cysteine repeat found in follistatin , a protein that binds and inhibits activin , another member of the TGFbeta superfamily .
12595574	5	10-cysteine	921,932	GASP-1	873,879	10-cysteine	GASP-1	null	278507(Tax:10090)	Chemical	Gene	repeat|amod|START_ENTITY contains|nmod|repeat contains|dep|END_ENTITY	GASP-1 also contains a domain homologous to the 10-cysteine repeat found in follistatin , a protein that binds and inhibits activin , another member of the TGFbeta superfamily .
18817775	3	10-DAB	482,488	Bcl-2	560,565	10-DAB	Bcl-2	null	596	Chemical	Gene	Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|END_ENTITY	Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same .
18817775	3	10-DAB	482,488	Caveolin-1	422,432	10-DAB	Caveolin-1	null	857	Chemical	Gene	Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment observed|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same .
18817775	3	10-DAB	482,488	ERK1/2	529,535	10-DAB	ERK1/2	null	5595;5594	Chemical	Gene	Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|Bcl-2 Bcl-2|compound|Raf-1 Raf-1|conj|END_ENTITY	Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same .
18817775	3	10-DAB	482,488	Raf-1	522,527	10-DAB	Raf-1	null	5894	Chemical	Gene	Taxol|conj|START_ENTITY treatment|conj|Taxol observed|nmod|treatment phosphorylated|ccomp|observed phosphorylated|dobj|Bcl-2 Bcl-2|compound|END_ENTITY	Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB , the former shows phosphorylated Raf-1 , ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same .
2428470	1	10-DAM	198,204	DHFR	332,336	10-DAM	DHFR	null	101121421	Chemical	Gene	methotrexate|appos|START_ENTITY derivatives|nmod|methotrexate tested|nsubjpass|derivatives tested|nmod|inhibitors inhibitors|nmod|dihydrofolate_reductase dihydrofolate_reductase|appos|END_ENTITY	Polyglutamyl derivatives of methotrexate -LRB- MTX -RRB- and 10-deazaaminopterin -LRB- 10-DAM -RRB- containing a total of one through six glutamate residues -LRB- Glu residues -RRB- were tested as inhibitors of dihydrofolate_reductase -LRB- DHFR -RRB- derived from sheep , chicken , and beef liver .
2428470	1	10-DAM	198,204	dihydrofolate_reductase	307,330	10-DAM	dihydrofolate reductase	null	101121421	Chemical	Gene	methotrexate|appos|START_ENTITY derivatives|nmod|methotrexate tested|nsubjpass|derivatives tested|nmod|inhibitors inhibitors|nmod|END_ENTITY	Polyglutamyl derivatives of methotrexate -LRB- MTX -RRB- and 10-deazaaminopterin -LRB- 10-DAM -RRB- containing a total of one through six glutamate residues -LRB- Glu residues -RRB- were tested as inhibitors of dihydrofolate_reductase -LRB- DHFR -RRB- derived from sheep , chicken , and beef liver .
17530898	4	10-DBC-8-Ade	749,761	10-DBC-8-Gua	766,778	10-DBC-8-Ade	10-DBC-8-Gua	MESH:C114328	9188	Chemical	Gene	START_ENTITY|conj|END_ENTITY	The C -LRB- 8 -RRB- - aryl adducts of adenine and guanine derived from BP -LRB- 6-BP-8-Ade and 6-BP-8-Gua -RRB- and DBC -LRB- 10-DBC-8-Ade and 10-DBC-8-Gua -RRB- were synthesized in good yields by this method .
26672353	0	10-Deacetyl_Baccatin	15,35	CO2	53,56	10-Deacetyl Baccatin	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	-LSB- Extraction of 10-Deacetyl_Baccatin by Supercritical CO2 from Taxus yunnanensis Branches and Leaves -RSB- .
7529746	10	10-deacetylbaccatine	1608,1628	TNF	1544,1547	10-deacetylbaccatine	TNF	MESH:C042213	21926(Tax:10090)	Chemical	Gene	III|amod|START_ENTITY not|conj|III not|nsubj|production production|compound|END_ENTITY	Taxol-induced TNF production was not inhibited by colchicine , vinblastine , or 10-deacetylbaccatine III .
23352123	5	10-deacetyl_baccatin_III	1207,1231	mgl-1	1196,1201	10-deacetyl baccatin III	mgl-1	MESH:C042213	3996	Chemical	Gene	Baccatin_III|conj|START_ENTITY Baccatin_III|appos|END_ENTITY	Maximum yields of Baccatin_III -LRB- 10.03 mgl-1 -RRB- and 10-deacetyl_baccatin_III -LRB- 4.2 mgl-1 -RRB- were achieved from the DKW basal media , but the yield of Taxol was maximum -LRB- 16.58 mgl-1 -RRB- in the WPM basal media .
23352123	5	10-deacetyl_baccatin_III	1207,1231	mgl-1	1326,1331	10-deacetyl baccatin III	mgl-1	MESH:C042213	3996	Chemical	Gene	Baccatin_III|conj|START_ENTITY yields|nmod|Baccatin_III achieved|nsubjpass|yields achieved|conj|maximum maximum|appos|END_ENTITY	Maximum yields of Baccatin_III -LRB- 10.03 mgl-1 -RRB- and 10-deacetyl_baccatin_III -LRB- 4.2 mgl-1 -RRB- were achieved from the DKW basal media , but the yield of Taxol was maximum -LRB- 16.58 mgl-1 -RRB- in the WPM basal media .
23352123	7	10-deacetyl_baccatin_III	1568,1592	mgl-1	1530,1535	10-deacetyl baccatin III	mgl-1	MESH:C042213	3996	Chemical	Gene	Taxol|conj|START_ENTITY Taxol|appos|END_ENTITY	The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media .
23352123	7	10-deacetyl_baccatin_III	1568,1592	mgl-1	1556,1561	10-deacetyl baccatin III	mgl-1	MESH:C042213	3996	Chemical	Gene	Taxol|conj|START_ENTITY Taxol|conj|Baccatin_III Baccatin_III|appos|END_ENTITY	The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media .
23352123	7	10-deacetyl_baccatin_III	1568,1592	mgl-1	1599,1604	10-deacetyl baccatin III	mgl-1	MESH:C042213	3996	Chemical	Gene	START_ENTITY|appos|END_ENTITY	The maximum extra-cellular yield of Taxol -LRB- 7.81 mgl-1 -RRB- , Baccatin_III -LRB- 5.0 mgl-1 -RRB- , and 10-deacetyl_baccatin_III -LRB- 1.45 mgl-1 -RRB- were also obtained by using DKW basal medium that were significantly higher than those obtained from other culture media .
10938416	0	10-deacetylbaccatin_III	25,48	C-10	68,72	10-deacetylbaccatin III	C-10	MESH:C042213	3226	Chemical	Gene	START_ENTITY|xcomp|baccatin baccatin|nmod|deacetylase deacetylase|compound|END_ENTITY	Enzymatic acetylation of 10-deacetylbaccatin_III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913 .
9891802	10	10-deacetylbaccatin_III	1684,1707	C-13	1727,1731	10-deacetylbaccatin III	C-13	MESH:C042213	3229	Chemical	Gene	III|amod|START_ENTITY III|nmod|chain chain|compound|END_ENTITY	The chemical coupling of 10-deacetylbaccatin_III or baccatin III to C-13 paclitaxel side chain has been summarized to prepare paclitaxel by semisynthesis .
9891802	5	10-deacetylbaccatin_III	845,868	C-13	889,893	10-deacetylbaccatin III	C-13	MESH:C042213	3229	Chemical	Gene	START_ENTITY|dep|paclitaxel paclitaxel|nmod|chain chain|compound|END_ENTITY	Three novel enzymes were discovered in our laboratory that converted the variety of taxanes to a single molecule , namely 10-deacetylbaccatin_III -LRB- paclitaxel without C-13 side chain and C-10_acetate -RRB- , a precursor for paclitaxel semisynthesis .
11451646	1	10-deacetylbaccatin_III	289,312	RP-2	264,268	10-deacetylbaccatin III	RP-2	MESH:C042213	6102	Chemical	Gene	purpose|nmod|START_ENTITY gel|nmod|purpose gel|appos|END_ENTITY	Solid-phase extraction was accomplished with specially prepared cartridges filled with silanised silica gel -LRB- RP-2 -RRB- for the purpose of 10-deacetylbaccatin_III -LRB- 10-DAB III -RRB- and related taxoids extracts purification obtained from different yew materials .
19795923	7	10-deacetyl-paclitaxel	1008,1030	CYP2C8	931,937	10-deacetyl-paclitaxel	CYP2C8	MESH:C095360	1558	Chemical	Gene	metabolized|nsubjpass|START_ENTITY metabolized|advcl|showed showed|nsubj|END_ENTITY	Although CYP2C8 showed a high capacity for metabolizing 7-epi-10-deacetyl-paclitaxel , 10-deacetyl-paclitaxel was hardly metabolized under the identical incubation conditions .
7915279	3	10-deacetyltaxol	693,709	C-13	586,590	10-deacetyltaxol	C-13	MESH:C031494	3229	Chemical	Gene	paclitaxel|conj|START_ENTITY removed|advcl|paclitaxel removed|dobj|chain chain|compound|END_ENTITY	A strain of Nocardioides albus -LRB- SC13911 -RRB- was isolated from soil and found to produce an extracellular enzyme that specifically removed the C-13 side chain from paclitaxel , cephalomannine , 7-beta-xylosyltaxol , 7-beta-xylosyl-10-deacetyltaxol , and 10-deacetyltaxol .
2369741	5	10-deazaaminopterin	862,881	C10	938,941	10-deazaaminopterin	C10	MESH:C017178	14790(Tax:10090)	Chemical	Gene	substitution|dep|START_ENTITY carbon|nmod|substitution aminopterin|conj|carbon Alkylation|nmod|aminopterin increased|nsubj|Alkylation increased|dobj|Km Km|acl|6-fold 6-fold|advcl|restored restored|nsubj|alkylation alkylation|nmod|_ _|compound|END_ENTITY	Alkylation of aminopterin -LRB- methotrexate -RRB- or carbon for nitrogen substitution -LRB- 10-deazaaminopterin -RRB- at N-10 increased Km 3 - to 6-fold , while alkylation at C10 _ -LRB- 10-ethyl-10-deazaaminopterin -RRB- restored Km to near equivalency with aminopterin .
2428470	0	10-deazaaminopterin	57,76	dihydrofolate_reductase	101,124	10-deazaaminopterin	dihydrofolate reductase	MESH:C017178	101121421	Chemical	Gene	methotrexate|conj|START_ENTITY methotrexate|conj|dihydrofolate dihydrofolate|nmod|END_ENTITY	Interaction of polyglutamyl derivatives of methotrexate , 10-deazaaminopterin , and dihydrofolate with dihydrofolate_reductase .
22280833	9	10-DEBC	779,786	Akt	752,755	10-DEBC	Akt	null	207	Chemical	Gene	FPA-124|conj|START_ENTITY FPA-124|compound|END_ENTITY	The effects of the Akt inhibitors FPA-124 and 10-DEBC on phenylephrine - , noradrenaline - and electric field stimulation - -LRB- EFS - -RRB- induced contraction were studied in myographic measurements .
23194750	4	10-DEBC	952,959	Akt	961,964	10-DEBC	Akt	null	24185(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Isolated rat femoral arteries segments were mounted in a wire myograph and challenged with 100mM KCl or phenylephrine -LRB- PE -RRB- , in the absence or presence of troglitazone , rosiglitazone , pioglitazone , LY294002 -LRB- PI3K inhibitor -RRB- and 10-DEBC -LRB- Akt inhibitor -RRB- .
23194750	6	10-DEBC	1353,1360	Akt	1461,1464	10-DEBC	Akt	null	24185(Tax:10116)	Chemical	Gene	thiazolidinediones|conj|START_ENTITY produced|nsubj|thiazolidinediones produced|dobj|decrease decrease|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Analysis of phospho-Akt -LRB- ser 473 -RRB- in lysates from rat arteries -LRB- by immunoblot -RRB- revealed that thiazolidinediones , LY294002 and 10-DEBC , at the same concentration and kinetics inhibiting vasoconstriction , produced a similar decrease of Akt phosphorylation .
27222231	9	10-DEBC	1178,1185	Akt	1203,1206	10-DEBC	Akt	null	207	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 .
25739982	6	10-DEBC	1085,1092	MEK1/2	1072,1078	10-DEBC	MEK1/2	null	5604;5605	Chemical	Gene	END_ENTITY|conj|START_ENTITY	U0126 -LRB- 5 M -RRB- , a specific inhibitor of -LRB- MEK1/2 -RRB- , and 10-DEBC -LRB- 2 M -RRB- , a selective inhibitor of AKT , both significantly reduced 17b-estradiol-induced phosphorylation of mTOR .
25739982	6	10-DEBC	1085,1092	mTOR	1201,1205	10-DEBC	mTOR	null	2475	Chemical	Gene	MEK1/2|conj|START_ENTITY inhibitor|nmod|MEK1/2 U0126|appos|inhibitor reduced|nsubj|U0126 reduced|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	U0126 -LRB- 5 M -RRB- , a specific inhibitor of -LRB- MEK1/2 -RRB- , and 10-DEBC -LRB- 2 M -RRB- , a selective inhibitor of AKT , both significantly reduced 17b-estradiol-induced phosphorylation of mTOR .
23194750	4	10-DEBC	952,959	PI3K	932,936	10-DEBC	PI3K	null	298947(Tax:10116)	Chemical	Gene	KCl|conj|START_ENTITY KCl|nmod|absence absence|nmod|inhibitor inhibitor|compound|END_ENTITY	Isolated rat femoral arteries segments were mounted in a wire myograph and challenged with 100mM KCl or phenylephrine -LRB- PE -RRB- , in the absence or presence of troglitazone , rosiglitazone , pioglitazone , LY294002 -LRB- PI3K inhibitor -RRB- and 10-DEBC -LRB- Akt inhibitor -RRB- .
27222231	9	10-DEBC	1178,1185	PI3K	1168,1172	10-DEBC	PI3K	null	5293	Chemical	Gene	LY294002|conj|START_ENTITY LY294002|dep|inhibitor inhibitor|nmod|END_ENTITY	Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 .
27222231	9	10-DEBC	1178,1185	Skp2	1312,1316	10-DEBC	Skp2	null	6502	Chemical	Gene	LY294002|conj|START_ENTITY reduced|nsubj|LY294002 reduced|conj|reduced reduced|dobj|expression expression|nmod|END_ENTITY	Both LY294002 -LRB- an inhibitor of PI3K -RRB- and 10-DEBC -LRB- an inhibitor of Akt -RRB- significantly reduced 17b-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2 .
21114978	8	10-DEBC_hydrochloride	1488,1509	Akt	1428,1431	10-DEBC hydrochloride	Akt	null	207	Chemical	Gene	LY294002|amod|START_ENTITY inhibitor|dep|LY294002 activation|conj|inhibitor activation|compound|END_ENTITY	On the other hand , metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC_hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects .
21114978	8	10-DEBC_hydrochloride	1488,1509	Akt	1474,1477	10-DEBC hydrochloride	Akt	null	207	Chemical	Gene	LY294002|amod|START_ENTITY inhibitor|dep|LY294002 inhibitor|compound|END_ENTITY	On the other hand , metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC_hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects .
23111315	6	10-DEBC_hydrochloride	1349,1370	Akt	1344,1347	10-DEBC hydrochloride	Akt	null	207	Chemical	Gene	END_ENTITY|dep|START_ENTITY	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
23111315	6	10-DEBC_hydrochloride	1349,1370	AMPK	1240,1244	10-DEBC hydrochloride	AMPK	null	5564	Chemical	Gene	Akt|dep|START_ENTITY inhibitors|appos|Akt LC3b|conj|inhibitors LC3b|compound|mTOR mTOR|compound|END_ENTITY	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
23111315	6	10-DEBC_hydrochloride	1349,1370	AMPK	1325,1329	10-DEBC hydrochloride	AMPK	null	5564	Chemical	Gene	Akt|dep|START_ENTITY inhibitors|appos|Akt inhibitors|nmod|END_ENTITY	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
23111315	6	10-DEBC_hydrochloride	1349,1370	LC3b	1274,1278	10-DEBC hydrochloride	LC3b	null	81631	Chemical	Gene	Akt|dep|START_ENTITY inhibitors|appos|Akt END_ENTITY|conj|inhibitors	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
23111315	6	10-DEBC_hydrochloride	1349,1370	mTOR	1246,1250	10-DEBC hydrochloride	mTOR	null	2475	Chemical	Gene	Akt|dep|START_ENTITY inhibitors|appos|Akt LC3b|conj|inhibitors LC3b|compound|END_ENTITY	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
23111315	6	10-DEBC_hydrochloride	1349,1370	mTOR	1373,1377	10-DEBC hydrochloride	mTOR	null	2475	Chemical	Gene	Akt|dep|START_ENTITY inhibitors|appos|Akt inhibitors|appos|END_ENTITY	The RNA interference-mediated silencing of AMPK , mTOR or autophagy-essential LC3b , as well as the pharmacological inhibitors of AMPK -LRB- compound C -RRB- , Akt -LRB- 10-DEBC_hydrochloride -RRB- , mTOR -LRB- rapamycin -RRB- and autophagy -LRB- bafilomycin_A1 , chloroquine and ammonium_chloride -RRB- , each suppressed mesenchymal stem cell differentiation to osteoblasts .
6355395	2	10-dehydogeniposide	394,413	C-8	200,203	10-dehydogeniposide	C-8	null	3224	Chemical	Gene	deacetylasperulosidic_acid_methylester|conj|START_ENTITY gave|dobj|deacetylasperulosidic_acid_methylester provided|advcl|gave provided|nsubj|hydrolysis hydrolysis|appos|epimer epimer|nmod|position position|compound|END_ENTITY	Enzymatic hydrolysis of galioside -LRB- 1 -RRB- and gardenoside -LRB- 2 -RRB- , epimer of 1 at C-8 position , provided the antimicrobially active aglucone -LRB- 3 -RRB- and the inactive 6 -LRB- a , b -RRB- , while acid treatment of 2 gave scandoside_methylester -LRB- 8 -RRB- , deacetylasperulosidic_acid_methylester -LRB- 9 -RRB- and 10-dehydogeniposide -LRB- 10 -RRB- .
24267247	1	10-dehydrogingerdione	187,208	CETP	167,171	10-dehydrogingerdione	CETP	MESH:C561631	100327267(Tax:9986)	Chemical	Gene	investigate|nmod|START_ENTITY investigate|dobj|suppression suppression|compound|END_ENTITY	OBJECTIVE : To investigate the CETP suppression by 10-dehydrogingerdione , a compound in Zingiber officinale , and its effect on the progression of atherosclerosis in dyslipidemic rabbits and the underlying oxidative and inflammatory consequences .
24267247	12	10-dehydrogingerdione	1707,1728	CETP	1774,1778	10-dehydrogingerdione	CETP	MESH:C561631	100327267(Tax:9986)	Chemical	Gene	lowers|amod|START_ENTITY LDL-C|nsubj|lowers LDL-C|advcl|suppressing suppressing|dobj|END_ENTITY	CONCLUSIONS : In a rabbit dyslipidemic_model , _ 10-dehydrogingerdione lowers LDL-C and raises HDL-C by suppressing CETP ; an effect that modulates inflammatory and oxidative risk factors of CVD .
24267247	13	10-dehydrogingerdione	1907,1928	CETP	1950,1954	10-dehydrogingerdione	CETP	MESH:C561631	100327267(Tax:9986)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	These findings suggested that the naturally occurring 10-dehydrogingerdione might be a potential CETP inhibitor for the treatment of atherosclerosis and residual risk in CVD .
25388083	3	10-dehydrogingerdione	456,477	CETP	494,498	10-dehydrogingerdione	CETP	MESH:C561631	100327267(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Therefore , 10-dehydrogingerdione -LRB- DHGD -RRB- , a novel CETP inhibitor isolated from ginger rhizomes , was selected as a natural product in the present study to illustrate its effect on haemostatic_impairment associated with hyperlipidemia as compared to a currently used hypocholesterolemic agent , atorvastatin -LRB- ATOR -RRB- .
24267247	11	10-dehydrogingerdione	1543,1564	MMP9	1622,1626	10-dehydrogingerdione	MMP9	MESH:C561631	100008993(Tax:9986)	Chemical	Gene	exerted|nsubj|START_ENTITY exerted|nmod|END_ENTITY	However , 10-dehydrogingerdione exerted better effect than atorvastatin on homocysteine , MMP9 -LRB- p < 0.001 -RRB- and ox-LDL -LRB- p < 0.05 -RRB- .
24267247	7	10-dehydrogingerdione	974,995	MMP9	937,941	10-dehydrogingerdione	MMP9	MESH:C561631	100008993(Tax:9986)	Chemical	Gene	rabbits|amod|START_ENTITY decreased|nmod|rabbits ox-LDL|acl|decreased ox-LDL|conj|END_ENTITY	Lp -LRB- a -RRB- , ox-LDL , hsCRP , homocysteine and MMP9 decreased significantly in both 10-dehydrogingerdione - and atorvastatin-treated rabbits compared with placebo -LRB- p < 0.001 -RRB- .
24267247	9	10-dehydrogingerdione	1232,1253	MMP9	1195,1199	10-dehydrogingerdione	MMP9	MESH:C561631	100008993(Tax:9986)	Chemical	Gene	returned|advcl|START_ENTITY returned|nsubj|END_ENTITY	Conversely , MMP9 returned below normal values by 10-dehydrogingerdione -LRB- p < 0.001 -RRB- , hsCRP and ox-LDL were slightly below normal values -LRB- hsCRP : p < 0.001 ; ox-LDL : p < 0.001 and p < 0.05 in 10-dehydrogingerdione and atorvastatin groups , respectively -RRB- .
24267247	9	10-dehydrogingerdione	1371,1392	MMP9	1195,1199	10-dehydrogingerdione	MMP9	MESH:C561631	100008993(Tax:9986)	Chemical	Gene	groups|amod|START_ENTITY p|nmod|groups hsCRP|dep|p slightly|dep|hsCRP slightly|parataxis|returned returned|nsubj|END_ENTITY	Conversely , MMP9 returned below normal values by 10-dehydrogingerdione -LRB- p < 0.001 -RRB- , hsCRP and ox-LDL were slightly below normal values -LRB- hsCRP : p < 0.001 ; ox-LDL : p < 0.001 and p < 0.05 in 10-dehydrogingerdione and atorvastatin groups , respectively -RRB- .
24267247	0	10-Dehydrogingerdione	0,21	CETP	55,59	10-Dehydrogingerdione	CETP	MESH:C561631	100327267(Tax:9986)	Chemical	Gene	raises|nsubj|START_ENTITY raises|nmod|inhibition inhibition|compound|END_ENTITY	10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits .
11212122	1	10-deoxy-10-C-morpholinoethyl	125,154	P-glycoprotein	245,259	10-deoxy-10-C-morpholinoethyl	P-glycoprotein	null	5243	Chemical	Gene	analogues|amod|START_ENTITY cytotoxicity|nmod|analogues improve|dobj|cytotoxicity improve|nmod|lines lines|nmod|cells cells|acl|expressing expressing|dobj|P-gp P-gp|compound|END_ENTITY	To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various_tumor cell lines including resistant cells expressing P-glycoprotein -LRB- P-gp -RRB- , we modified the 7-hydroxyl group to hydrophobic groups -LRB- methoxy , deoxy , 6,7-olefin , alpha-F , _ 7-beta-8-beta-methano , fluoromethoxy -RRB- .
11212122	1	10-deoxy-10-C-morpholinoethyl	125,154	P-gp	261,265	10-deoxy-10-C-morpholinoethyl	P-gp	null	5243	Chemical	Gene	analogues|amod|START_ENTITY cytotoxicity|nmod|analogues improve|dobj|cytotoxicity improve|nmod|lines lines|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	To improve cytotoxicity of 10-deoxy-10-C-morpholinoethyl docetaxel analogues against various_tumor cell lines including resistant cells expressing P-glycoprotein -LRB- P-gp -RRB- , we modified the 7-hydroxyl group to hydrophobic groups -LRB- methoxy , deoxy , 6,7-olefin , alpha-F , _ 7-beta-8-beta-methano , fluoromethoxy -RRB- .
8691428	9	10-deoxydehydroryanodine	1436,1460	ryr	1215,1218	10-deoxydehydroryanodine	ryr	null	689560(Tax:10116)	Chemical	Gene	epi-1|conj|START_ENTITY epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY	Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine .
16251298	4	10-deoxynystatin	869,885	C-10	936,940	10-deoxynystatin	C-10	null	3226	Chemical	Gene	START_ENTITY|appos|precursor precursor|acl|lacking lacking|nmod|END_ENTITY	Liquid chromatography-mass spectrometry and nuclear magnetic resonance structural analyses of the latter metabolite confirmed its identity as 10-deoxynystatin , a nystatin precursor lacking a hydroxyl group at C-10 .
7579732	3	10-dideazatetrahydrofolic_acid	676,706	mFBP	649,653	10-dideazatetrahydrofolic acid	mFBP	null	51886(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY 5|conj|-RSB- Antifolates|dep|5 Antifolates|acl:relcl|has has|nsubj|END_ENTITY	Antifolates for which KB-derived mFBP has high affinity -LRB- 5 , 10-dideazatetrahydrofolic_acid -LSB- DDATHF -RSB- and homo-DDATHF -LSB- 0.24 and 0.78 respectively relative to folic_acid -RSB- -RRB- and low affinity -LRB- methotrexate -LSB- 0.002 -RSB- -RRB- were chosen for this study .
25862844	10	10-dihydroartemisinyl-2-propylpentanoate	1397,1437	VEGFR1	1353,1359	10-dihydroartemisinyl-2-propylpentanoate	VEGFR1	null	2321	Chemical	Gene	dimer|conj|START_ENTITY found|nmod|dimer found|nsubjpass|affinities affinities|nmod|END_ENTITY	The best binding affinities to VEGFR1 were found for an artemisinin dimer , 10-dihydroartemisinyl-2-propylpentanoate , and dihydroartemisinin_a-hemisuccinate_sodium salt .
22583689	0	10E12Z-CLA	23,33	COX-2	72,77	10E12Z-CLA	COX-2	MESH:C496197	17709(Tax:10090)	Chemical	Gene	expression|nummod|START_ENTITY fatty_acid|dobj|expression fatty_acid|nmod|synthesis synthesis|amod|dependent dependent|amod|END_ENTITY	The dietary fatty_acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF -LRB- 2a -RRB- synthesis in adipocytes .
22583689	0	10E12Z-CLA	23,33	PGF	88,91	10E12Z-CLA	PGF	MESH:C496197	18654(Tax:10090)	Chemical	Gene	expression|nummod|START_ENTITY fatty_acid|dobj|expression fatty_acid|nmod|synthesis synthesis|compound|END_ENTITY	The dietary fatty_acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF -LRB- 2a -RRB- synthesis in adipocytes .
15176054	9	10E3-G4-D3	1156,1166	prostein	1217,1225	10E3-G4-D3	prostein	null	85414	Chemical	Gene	utility|nmod|START_ENTITY indicating|dobj|utility specific|xcomp|indicating specific|conj|support support|dobj|use use|nmod|END_ENTITY	CONCLUSIONS : Prostein is exquisitely specific for prostate tissues , indicating a potential clinical utility of 10E3-G4-D3 as a diagnostic biomarker , and support the use of prostein as a novel target for development of prostein-specific antibody and T-cell based therapeutic strategies for prostate_cancer .
15176054	9	10E3-G4-D3	1156,1166	Prostein	1058,1066	10E3-G4-D3	Prostein	null	85414	Chemical	Gene	utility|nmod|START_ENTITY indicating|dobj|utility specific|xcomp|indicating specific|nsubj|END_ENTITY	CONCLUSIONS : Prostein is exquisitely specific for prostate tissues , indicating a potential clinical utility of 10E3-G4-D3 as a diagnostic biomarker , and support the use of prostein as a novel target for development of prostein-specific antibody and T-cell based therapeutic strategies for prostate_cancer .
17944754	4	10E4	542,546	beta-catenin	576,588	10E4	beta-catenin	MESH:C005629	1499	Chemical	Gene	HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY	Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 .
17944754	4	10E4	542,546	BMP-4	594,599	10E4	BMP-4	MESH:C005629	652	Chemical	Gene	HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY	Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 .
17944754	4	10E4	542,546	Wnt-2	569,574	10E4	Wnt-2	MESH:C005629	7472	Chemical	Gene	HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY	Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 .
17944754	4	10E4	542,546	Wnt-5a	561,567	10E4	Wnt-5a	MESH:C005629	7474	Chemical	Gene	HS|appos|START_ENTITY HS|amod|heparanase heparanase|conj|END_ENTITY	Immunohistochemistry was performed to detect basement membrane type heparan_sulfate -LRB- HS -RRB- -LRB- JM403 -RRB- , cell surface type HS -LRB- 10E4 -RRB- , heparanase , Wnt-5a , Wnt-2 , beta-catenin , and BMP-4 .
1400325	4	10E5	939,943	RGDS	893,897	10E5	RGDS	MESH:C005629	5900	Chemical	Gene	antibody|nummod|START_ENTITY peptide_Arg-Gly-Asp-Ser|conj|antibody peptide_Arg-Gly-Asp-Ser|appos|END_ENTITY	Cytoskeletal association and platelet_aggregation were inhibited by the peptide_Arg-Gly-Asp-Ser -LRB- RGDS -RRB- -LRB- but not by Arg-Gly-Glu-Ser -LRB- RGES -RRB- -RRB- , by 10E5 antibody against glycoprotein -LRB- Gp -RRB- IIb/IIIa , and by EGTA .
1329249	5	10E5_heparin	1138,1150	RGDS	1030,1034	10E5 heparin	RGDS	MESH:C005629	5900	Chemical	Gene	enhance|nsubj|START_ENTITY platelet_aggregation|dep|enhance increased|nsubj|platelet_aggregation increased|nmod|pretreatment pretreatment|nmod|END_ENTITY	Following pretreatment with RGDS , heparin increased platelet_aggregation -LRB- p less than 0.03 -RRB- , while after pretreatment with antibody MAb 10E5_heparin did not enhance platelet_aggregation .
2448650	6	10EdAM	1025,1031	MX-1	1109,1113	10EdAM	MX-1	MESH:C040210	4599	Chemical	Gene	superiority|nmod|START_ENTITY shown|nsubjpass|superiority shown|nmod|xenografts xenografts|conj|END_ENTITY	Marked superiority of 10EdAM compared to MTX was also shown against the following human tumor xenografts : MX-1 -LRB- mammary_carcinoma -RRB- , LX-1 -LRB- small_cell_lung_carcinoma -RRB- and CX-1 -LRB- colon_carcinoma -RRB- .
2448650	7	10EdAM	1196,1202	MX-1	1256,1260	10EdAM	MX-1	MESH:C040210	4599	Chemical	Gene	produced|nsubj|START_ENTITY produced|dobj|regressions regressions|nmod|tumor tumor|compound|END_ENTITY	10EdAM produced 30 % to 40 % complete regressions against the MX-1 tumor .
1655252	10	10-EdAM	2498,2505	mFBP	2433,2437	10-EdAM	mFBP	MESH:C040210	51886(Tax:10090)	Chemical	Gene	consistent|conj|START_ENTITY consistent|nmod|studies studies|nmod|cells cells|acl|demonstrating demonstrating|ccomp|played played|nsubj|END_ENTITY	Results from affinity and membrane transport observations were consistent with growth inhibition studies on L1210-B73 cells demonstrating that the mFBP played only a minor role in the cytotoxic effects of MTX or 10-EdAM .
1655252	5	10-EdAM	1674,1681	mFBP	1568,1572	10-EdAM	mFBP	MESH:C040210	51886(Tax:10090)	Chemical	Gene	MTX|conj|START_ENTITY affinity|nmod|MTX ICI-198|nmod|affinity affinity|conj|ICI-198 exhibited|dobj|affinity exhibited|nsubj|END_ENTITY	The mFBP exhibited a high binding affinity for CB3717 and ICI-198 ,583 but a poor binding affinity for MTX and 10-EdAM .
1655252	6	10-EdAM	1853,1860	mFBP	1709,1713	10-EdAM	mFBP	MESH:C040210	51886(Tax:10090)	Chemical	Gene	ICI-198|dep|START_ENTITY folic_acid|dobj|ICI-198 equal|xcomp|folic_acid decreased|conj|equal decreased|nsubj|affinities affinities|nmod|END_ENTITY	Binding affinities of the mFBP decreased in the order CB3717 greater than or equal to folic_acid = ICI-198 ,583 greater than or equal to 5-CHO-THF much greater than MTX = 10-EdAM .
7641196	2	10-EdAM	1143,1150	mFBP	1015,1019	10-EdAM	mFBP	MESH:C040210	51886(Tax:10090)	Chemical	Gene	ZD1694|amod|START_ENTITY acid|compound|ZD1694 MTX|appos|acid sensitive|nmod|MTX demonstrated|parataxis|sensitive demonstrated|dobj|lack lack|nmod|correlation correlation|nmod|affinity affinity|nmod|END_ENTITY	Regardless of the medium folate status , growth inhibition studies with IGROV-I and MA104 cells demonstrated a lack of correlation between the affinity of mFBP for the antifolate drugs and their sensitivity profile ; both cell lines were highly sensitive to growth inhibition by MTX , 10-EdAM , ZD1694 and 5,10-dideazatetrahydrofolic _ acid , but were insensitive for CB3717 .
1655252	3	10-EdAM	1133,1140	thymidylate_synthase	1177,1197	10-EdAM	thymidylate synthase	MESH:C040210	22171(Tax:10090)	Chemical	Gene	methotrexate|dep|START_ENTITY reductase|nmod|methotrexate inhibitors|nmod|reductase inhibitors|conj|inhibitors inhibitors|nmod|END_ENTITY	The antifolates used were either inhibitors of dihydrofolate reductase , including methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazaaminopterin -LRB- 10-EdAM -RRB- , or two folate-based inhibitors of thymidylate_synthase , N10-propargyl-5 ,8 - dideazafolic_acid -LRB- CB3717 -RRB- and 2-deamino-2-methyl-N10-propargyl-5 ,8 - dideazafolic_acid -LRB- ICI-198 ,583 -RRB- .
2832548	1	10-EDAM	141,148	N10	233,236	10-EDAM	N10	MESH:C040210	3164	Chemical	Gene	10-ethyl-10-deaza-aminopterin|appos|START_ENTITY analog|nsubj|10-ethyl-10-deaza-aminopterin analog|acl:relcl|differs differs|nmod|modification modification|nmod|position position|compound|END_ENTITY	10-ethyl-10-deaza-aminopterin -LRB- 10-EDAM -RRB- is an analog of methotrexate that differs from its compound by modification of the N10 position and demonstrates greater preclinical antitumor activity and less toxicity .
11356934	3	10-epi-8-deoxycumambrin_B	522,547	aromatase	381,390	10-epi-8-deoxycumambrin B	aromatase	null	1588	Chemical	Gene	group|nmod|START_ENTITY reduced|dobj|group reduced|advcl|synthesize synthesize|nmod|specificity specificity|nmod|inhibition inhibition|amod|END_ENTITY	To synthesize sesquiterpene_lactones with greater specificity for aromatase inhibition and lower cytotoxicity , we chemically reduced the alpha-methylene-gamma-lactone group in the active aromatase inhibitor 10-epi-8-deoxycumambrin_B -LRB- compound 1 -RRB- , to obtain the new compound 11betaH,13-dihydro-10-epi-8-deoxycumambrin _ B -LRB- compound 2 -RRB- .
11356934	3	10-epi-8-deoxycumambrin_B	522,547	aromatase	502,511	10-epi-8-deoxycumambrin B	aromatase	null	1588	Chemical	Gene	START_ENTITY|amod|END_ENTITY	To synthesize sesquiterpene_lactones with greater specificity for aromatase inhibition and lower cytotoxicity , we chemically reduced the alpha-methylene-gamma-lactone group in the active aromatase inhibitor 10-epi-8-deoxycumambrin_B -LRB- compound 1 -RRB- , to obtain the new compound 11betaH,13-dihydro-10-epi-8-deoxycumambrin _ B -LRB- compound 2 -RRB- .
8691428	9	10-epi-amino	1351,1363	ryr	1215,1218	10-epi-amino	ryr	null	689560(Tax:10116)	Chemical	Gene	epi-1|dep|START_ENTITY epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY	Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine .
8691428	9	10-epi-azidobenzoyl_hydrazide	1390,1419	ryr	1215,1218	10-epi-azidobenzoyl hydrazide	ryr	null	689560(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY 10-epi-amino|conj|derivatives epi-1|dep|10-epi-amino epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY	Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine .
26947062	7	10-epi-cubebol	821,835	Sce6369	788,795	10-epi-cubebol	Sce6369	null	5810909(Tax:448385)	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|appos|synthase	In contrast , Sce6369 , the first characterized 10-epi-cubebol synthase , is responsible for the formation of most of the So_ce56 sesquiterpenes , mainly cadalanes and cubebanes .
8691428	9	10-epi-methoxyamino	1365,1384	ryr	1215,1218	10-epi-methoxyamino	ryr	null	689560(Tax:10116)	Chemical	Gene	10-epi-amino|conj|START_ENTITY epi-1|dep|10-epi-amino epi-1|nsubj|Ryanoids Ryanoids|nmod|potency potency|nmod|inhibitors inhibitors|nmod|assay assay|amod|binding binding|nmod|brain brain|conj|preparations preparations|compound|END_ENTITY	Ryanoids of similar potency to 1 as inhibitors of -LSB- 3H -RSB- -1 binding in mouse brain , rabbit skeletal muscle , and canine ventricle ryr preparations and in rat cardiac contractility assay -LRB- inhibition of mechanical response to electrical stimulation -RRB- are epi-1 and the 10-epi-amino , 10-epi-methoxyamino , and 10-epi-azidobenzoyl_hydrazide derivatives and 10-deoxydehydroryanodine .
23497874	2	10-epi-y-eudesmol	465,482	OGR1	382,386	10-epi-y-eudesmol	OGR1	null	8111	Chemical	Gene	-1|conj|START_ENTITY levels|nmod|-1 constituted|dobj|levels constituted|nsubj|oil oil|nmod|END_ENTITY	Essential oil from OGR1 was constituted high levels of -LRB- E -RRB- -1 - propenyl_sec-butyl_disulfide -LRB- 23.9 % -RRB- and 10-epi-y-eudesmol -LRB- 15.1 % -RRB- .
20962051	4	10-ethenyl-19-norprogesterone	1284,1313	mPRa	1270,1274	10-ethenyl-19-norprogesterone	mPRa	null	20200(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa .
20962051	4	10-ethenyl-19-norprogesterone	1284,1313	mPRa	1408,1412	10-ethenyl-19-norprogesterone	mPRa	null	20200(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY mimicked|nsubj|agonist mimicked|dobj|action action|nmod|death death|acl:relcl|lost lost|nmod|knockdown knockdown|nmod|protein protein|compound|END_ENTITY	Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa .
20962051	4	10-ethenyl-19-norprogesterone	1284,1313	mPRa	1508,1512	10-ethenyl-19-norprogesterone	mPRa	null	20200(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY mimicked|nsubj|agonist mimicked|dobj|action action|nmod|death death|acl:relcl|lost lost|xcomp|demonstrating demonstrating|dobj|involvement involvement|nmod|END_ENTITY	Moreover , a selective mPRa agonist , 10-ethenyl-19-norprogesterone , mimicked the protective action of 20b-S against cell death , which was lost upon knockdown of mPRa protein but not after progesterone receptor knockdown , further demonstrating an involvement of mPRa .
24530629	4	10-ethenyl-19-norprogesterone	726,755	mPRa	712,716	10-ethenyl-19-norprogesterone	mPRa	null	20200(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The specific mPRa agonist , 10-ethenyl-19-norprogesterone -LRB- Org_OD 02-0 , 100nM -RRB- , mimicked the stimulatory actions of the endogenous progestin , _ 17,20 b , _ 21-trihydroxy-4-pregnen-3-one -LRB- 20b-S , 100nM -RRB- on flounder sperm motility .
24695628	3	10-ethenyl-19-norprogesterone	772,801	mPRalpha	755,763	10-ethenyl-19-norprogesterone	mPRalpha	null	20200(Tax:10090)	Chemical	Gene	START_ENTITY|compound|END_ENTITY	The specific mPRalpha agonist 10-ethenyl-19-norprogesterone -LRB- Org_OD 02-0 -RRB- mimicked the stimulatory actions of the endogenous progestin in this species , 17 , _ 20beta , _ 21-trihydroxy-4-pregnen-3-one -LRB- 20beta-S -RRB- , on sperm motility .
7057422	4	10-ethoxalylfolic_acid	545,567	THF	606,609	10-ethoxalylfolic acid	THF	MESH:C052091	21831(Tax:10090)	Chemical	Gene	hydrogenation|nmod|START_ENTITY rearranged|nmod|hydrogenation rearranged|nsubj|product product|dep|EtO2CCO EtO2CCO|dep|END_ENTITY	In the catalytic hydrogenation of 10-ethoxalylfolic_acid -LRB- 5 -RRB- , the initial product 10 - -LRB- EtO2CCO -RRB- - THF -LRB- 22 -RRB- rearranged readily to give 5 - -LRB- EtO2CCO -RRB- - THF -LRB- 21 -RRB- .
3978616	6	10-ethyl-10-deazaaminopterin	1625,1653	folylpolyglutamyl_synthetase	1765,1793	10-ethyl-10-deazaaminopterin	folylpolyglutamyl synthetase	MESH:C040210	14287(Tax:10090)	Chemical	Gene	equal|nmod|START_ENTITY equal|xcomp|suggesting suggesting|ccomp|have have|nsubj|END_ENTITY	In contrast , the relative rates of polyglutamylation in Manca cells were in the order 10-ethyl-10-deazaaminopterin approximately equal to aminopterin greater than 10-deazaaminopterin greater than methotrexate , suggesting that folylpolyglutamyl_synthetase may have varying substrate preferences in different cell types .
2369741	7	10-ethyl-10-deazaaminopterin	1380,1408	FPGS	1282,1286	10-ethyl-10-deazaaminopterin	FPGS	MESH:C040210	14287(Tax:10090)	Chemical	Gene	2-fold|dep|START_ENTITY similar|conj|2-fold similar|nsubj|Values Values|dep|derived derived|nmod|END_ENTITY	Values for Vmax -LRB- derived with partially purified FPGS -RRB- for the other 4-aminofolate analogues and folic_acid were similar -LRB- methotrexate -RRB- or 2-fold -LRB- 10-ethyl-10-deazaaminopterin -RRB- and 5-fold -LRB- folic_acid -RRB- lower than for aminopterin .
11705857	10	10-ethyl-10-deazaaminopterin	1942,1970	hRFC	1777,1781	10-ethyl-10-deazaaminopterin	hRFC	MESH:C040210	6573	Chemical	Gene	Tomudex|conj|START_ENTITY substrates|nmod|Tomudex measured|nmod|substrates measured|advcl|were were|nsubj|differences differences|nmod|parameters parameters|nmod|transport transport|nmod|forms forms|amod|END_ENTITY	Although there were no significant differences between the kinetic parameters for methotrexate transport for the hRFC forms , minor -LRB- approximately 2-fold -RRB- differences were measured in the K -LRB- i -RRB- s for other substrates including Tomudex , 5,10-dideazatetrahydrofolate , GW1843U89 , and 10-ethyl-10-deazaaminopterin and for 5-formyl_tetrahydrofolate .
1655252	3	10-ethyl-10-deazaaminopterin	1103,1131	thymidylate_synthase	1177,1197	10-ethyl-10-deazaaminopterin	thymidylate synthase	MESH:C040210	22171(Tax:10090)	Chemical	Gene	methotrexate|conj|START_ENTITY reductase|nmod|methotrexate inhibitors|nmod|reductase inhibitors|conj|inhibitors inhibitors|nmod|END_ENTITY	The antifolates used were either inhibitors of dihydrofolate reductase , including methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazaaminopterin -LRB- 10-EdAM -RRB- , or two folate-based inhibitors of thymidylate_synthase , N10-propargyl-5 ,8 - dideazafolic_acid -LRB- CB3717 -RRB- and 2-deamino-2-methyl-N10-propargyl-5 ,8 - dideazafolic_acid -LRB- ICI-198 ,583 -RRB- .
1831805	1	10-ethyl-10-deazaaminopterin	356,384	thymidylate_synthase	222,242	10-ethyl-10-deazaaminopterin	thymidylate synthase	MESH:C040210	29261(Tax:10116)	Chemical	Gene	methotrexate|conj|START_ENTITY predict|nmod|methotrexate measures|advcl|predict measures|dobj|activity activity|amod|END_ENTITY	A methylcholanthrene-induced rat_sarcoma propagated both in vitro and in vivo was used to examine the usefulness of a rapid biochemical in situ assay that measures thymidylate_synthase -LRB- TS -RRB- activity in whole cells to predict sensitivity and resistance to the folate antagonists methotrexate -LRB- MTX -RRB- , 10-ethyl-10-deazaaminopterin -LRB- 10-EDAM -RRB- and trimetrexate -LRB- TMTX -RRB- .
2832548	1	10-ethyl-10-deaza-aminopterin	110,139	N10	233,236	10-ethyl-10-deaza-aminopterin	N10	MESH:C040210	3164	Chemical	Gene	analog|nsubj|START_ENTITY analog|acl:relcl|differs differs|nmod|modification modification|nmod|position position|compound|END_ENTITY	10-ethyl-10-deaza-aminopterin -LRB- 10-EDAM -RRB- is an analog of methotrexate that differs from its compound by modification of the N10 position and demonstrates greater preclinical antitumor activity and less toxicity .
7553969	1	10-ethyl-10-deazapterin	956,979	DHFR	862,866	10-ethyl-10-deazapterin	DHFR	null	1719	Chemical	Gene	potent|conj|START_ENTITY potent|conj|potent potent|nmod|inhibitors inhibitors|compound|END_ENTITY	These new analogs are highly potent as DHFR and cell growth inhibitors , and most of them are more potent than methotrexate -LRB- MTX -RRB- and 10-ethyl-10-deazapterin -LRB- 10-EDAM -RRB- in inhibiting tumor cell growth -LRB- P388 MTX-sensitive and MTX-resistant , colon 26 and KB -RRB- on 72 h drug exposure .
7519382	0	10-ethyl-deaza-aminopterin	138,164	prostate-specific_antigen	23,48	10-ethyl-deaza-aminopterin	prostate-specific antigen	null	354	Chemical	Gene	trial|nmod|START_ENTITY change|dep|trial change|nmod|levels levels|amod|END_ENTITY	Post-therapy change in prostate-specific_antigen levels as a clinical trial endpoint in hormone-refractory prostatic_cancer : a trial with 10-ethyl-deaza-aminopterin .
9092577	6	10-FDDF	1314,1321	FDH	1251,1254	10-FDDF	FDH	MESH:C092738	64392(Tax:10116)	Chemical	Gene	activity|nummod|START_ENTITY occurred|nsubj|activity independent|advcl|occurred independent|nsubj|activity activity|nmod|domain domain|conj|END_ENTITY	Aldehyde dehydrogenase activity of the COOH-terminal domain and FDH was independent of the presence of 2-mercaptoethanol while 10-FDDF dehydrogenase activity of FDH occurred only in the presence of 2-mercaptoethanol .
9092577	6	10-FDDF	1314,1321	FDH	1348,1351	10-FDDF	FDH	MESH:C092738	64392(Tax:10116)	Chemical	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Aldehyde dehydrogenase activity of the COOH-terminal domain and FDH was independent of the presence of 2-mercaptoethanol while 10-FDDF dehydrogenase activity of FDH occurred only in the presence of 2-mercaptoethanol .
18930948	2	10-fluoroethoxyphosphinyl-N-biotinamido_pentyldecanamide	382,438	transferrin	289,300	10-fluoroethoxyphosphinyl-N-biotinamido pentyldecanamide	transferrin	MESH:C403065	7018	Chemical	Gene	modified|nmod|START_ENTITY modified|nsubjpass|END_ENTITY	However , transferrin , a protein with no active site serine , was covalently modified in vitro by 0.5 mM 10-fluoroethoxyphosphinyl-N-biotinamido_pentyldecanamide , chlorpyrifos_oxon , diisopropylfluorophosphate , dichlorvos , sarin , and soman .
1989499	1	10-formylfolate	112,127	thymidylate_synthase	175,195	10-formylfolate	thymidylate synthase	null	7298	Chemical	Gene	derivatives|nmod|START_ENTITY evaluated|nsubjpass|derivatives evaluated|nmod|inhibitors inhibitors|nmod|END_ENTITY	Reduced derivatives of 10-formylfolate have been evaluated as inhibitors of mammalian thymidylate_synthase -LRB- EC 2.1.1.45 -RRB- from H35 hepatoma cells .
10985775	7	10-formyl-folate	1696,1712	AICAR	1682,1687	10-formyl-folate	AICAR	null	471	Chemical	Gene	cofactor|amod|START_ENTITY END_ENTITY|conj|cofactor	We have determined the equilibrium constant of the transformylase reaction to be 0.024 + / - 0.001 , showing that the reaction strongly favors AICAR and the 10-formyl-folate cofactor .
3366769	3	10-formyl-H2folate	797,815	AICAR	886,891	10-formyl-H2folate	AICAR	null	471	Chemical	Gene	examined|nsubjpass|START_ENTITY examined|nmod|interaction interaction|conj|transformylase transformylase|amod|END_ENTITY	Chemically synthesized monoglutamated or pentaglutamated 10-formyl-H2folate was examined for its interaction with three folate-dependent enzymes : AICAR transformylase , glucinamide_ribotide -LRB- GAR -RRB- transformylase , and thymidylatesynthase .
3366769	8	10-formyl-H2folate	1710,1728	AICAR	1951,1956	10-formyl-H2folate	AICAR	null	471	Chemical	Gene	role|nmod|START_ENTITY determined|nsubjpass|role has|advcl|determined has|dobj|potential potential|acl|enhance enhance|dobj|inhibition inhibition|nmod|GAR GAR|conj|time time|dep|provides provides|dobj|substrate substrate|nmod|transformylase transformylase|amod|END_ENTITY	While the actual role of 10-formyl-H2folate contributing to the cytotoxicity of MTX has not been determined , this compound has the potential to enhance inhibition of GAR transformylase and thymidylate_synthase , and at the same time provides additional substrate for AICAR transformylase .
3366769	6	10-formyl-H2folate	1416,1434	thymidylate_synthase	1392,1412	10-formyl-H2folate	thymidylate synthase	null	7298	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	The inhibition of thymidylate_synthase by 10-formyl-H2folate was highly dependent on the inhibitor 's polyglutamation state , the - Glu5 derivative having a 52-85-fold greater affinity as compared to the affinity of - Glu1 .
3366769	8	10-formyl-H2folate	1710,1728	thymidylate_synthase	1874,1894	10-formyl-H2folate	thymidylate synthase	null	7298	Chemical	Gene	role|nmod|START_ENTITY determined|nsubjpass|role has|advcl|determined has|dobj|potential potential|acl|enhance enhance|dobj|inhibition inhibition|nmod|GAR GAR|amod|transformylase transformylase|conj|END_ENTITY	While the actual role of 10-formyl-H2folate contributing to the cytotoxicity of MTX has not been determined , this compound has the potential to enhance inhibition of GAR transformylase and thymidylate_synthase , and at the same time provides additional substrate for AICAR transformylase .
3366769	9	10-formyl-H2folate	2019,2037	thymidylate_synthase	2163,2183	10-formyl-H2folate	thymidylate synthase	null	7298	Chemical	Gene	accumulation|nmod|START_ENTITY play|nsubj|accumulation play|nmod|inhibition inhibition|nmod|END_ENTITY	The MTX-induced intracellular accumulation of 10-formyl-H2folate and H2folate may play a role in the drug-related cytotoxicity through the contribution of these folates to the inhibition of thymidylate_synthase and de novo purine synthesis .
3091098	5	10-formyl-H4folate	847,865	cystathionine_beta-synthase	943,970	10-formyl-H4folate	cystathionine beta-synthase	null	875	Chemical	Gene	synthetase|amod|START_ENTITY cycle|conj|synthetase enzymes|nmod|cycle enzymes|conj|END_ENTITY	We also measured the activities of another three enzymes of the folic_acid cycle , viz. , 5,10-methylene-H4folate dehydrogenase , 10-formyl-H4folate synthetase , and 5,10-methenyl-H4folate cyclohydrolase , as well as the enzyme cystathionine_beta-synthase .
3366769	5	10-formyl-H4folate-Glu5	1349,1372	AICAR	1247,1252	10-formyl-H4folate-Glu5	AICAR	null	471	Chemical	Gene	that|nmod|START_ENTITY equal|nmod|that acted|conj|equal acted|nmod|substrate substrate|nmod|transformylase transformylase|amod|END_ENTITY	It acted as a substrate for AICAR transformylase -LRB- Km = 5.3 microM -RRB- , and its efficiency was equal to that of the natural substrate 10-formyl-H4folate-Glu5 .
6351556	1	10-formyl-H4PteGlu	399,417	thymidylate_synthase	338,358	10-formyl-H4PteGlu	thymidylate synthase	null	7298	Chemical	Gene	synthetase|amod|START_ENTITY END_ENTITY|conj|synthetase	In the past few years we have been engaged in studying several folate cofactor requiring enzymes derived from human cells ; namely thymidylate_synthase , dihydrofolate reductase , folyl binder , 10-formyl-H4PteGlu synthetase , 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase .
6351556	3	10-formyl-H4PteGlu	739,757	thymidylate_synthase	717,737	10-formyl-H4PteGlu	thymidylate synthase	null	7298	Chemical	Gene	synthetase|amod|START_ENTITY substrates|conj|synthetase substrates|nmod|END_ENTITY	Folylpolyglutamates are better substrates for thymidylate_synthase , 10-formyl-H4PteGlu synthetase , and 5,10-methylene-H4PteGlu dehydrogenase when NADP is lower than 30 microM , whereas dihydrofolate reductase and membrane associated folyl binder do not distinguish between folylmono - _ and_polyglutamates .
6351556	0	10-formyl-H4PteGlu	61,79	Thymidylate_synthase	0,20	10-formyl-H4PteGlu	Thymidylate synthase	null	7298	Chemical	Gene	synthetase|amod|START_ENTITY reductase|conj|synthetase derived|nsubj|reductase derived|advmod|END_ENTITY	Thymidylate_synthase , dihydrofolate reductase , folyl binder , 10-formyl-H4PteGlu synthetase , 5,10-methenyl-H4PteGlu cyclohydrolase and 5,10-methylene-H4PteGlu dehydrogenase derived from cells of human origin .
11320079	1	10-formyltetrahydrofolate	220,245	10-formyltetrahydrofolate_dehydrogenase	164,203	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	10840	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|enzyme enzyme|appos|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction .
3392008	2	10-formyltetrahydrofolate	399,424	10-formyltetrahydrofolate_dehydrogenase	257,296	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY copurifying|dobj|activity presence|acl|copurifying indicated|dobj|presence indicated|nsubj|studies studies|nmod|END_ENTITY	Previous studies of 10-formyltetrahydrofolate_dehydrogenase purified from rat or pig liver homogenized in phosphate buffers indicated the presence of copurifying 10-formyltetrahydrofolate hydrolase activity , which catalyzes conversion of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
3392008	2	10-formyltetrahydrofolate	475,500	10-formyltetrahydrofolate_dehydrogenase	257,296	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion activity|acl:relcl|catalyzes copurifying|dobj|activity presence|acl|copurifying indicated|dobj|presence indicated|nsubj|studies studies|nmod|END_ENTITY	Previous studies of 10-formyltetrahydrofolate_dehydrogenase purified from rat or pig liver homogenized in phosphate buffers indicated the presence of copurifying 10-formyltetrahydrofolate hydrolase activity , which catalyzes conversion of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
7822273	1	10-formyltetrahydrofolate	235,260	10-formyltetrahydrofolate_dehydrogenase	120,159	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY enzyme|dep|oxidation enzyme|appos|catalyzes catalyzes|amod|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
7822273	1	10-formyltetrahydrofolate	331,356	10-formyltetrahydrofolate_dehydrogenase	120,159	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY enzyme|dep|hydrolysis enzyme|appos|catalyzes catalyzes|amod|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
7972060	3	10-formyltetrahydrofolate	583,608	10-formyltetrahydrofolate_dehydrogenase	524,563	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	107747(Tax:10090)	Chemical	Gene	DH|dep|START_ENTITY identified|dep|DH identified|nmod|forms forms|nmod|END_ENTITY	Characterization of this protein_deficiency has identified these liver proteins as forms of the enzyme 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-formyl-THF DH ; 10-formyltetrahydrofolate : NADP + oxidoreductase , EC 1.5.1.6 -RRB- .
8527931	1	10-formyltetrahydrofolate	241,266	10-formyltetrahydrofolate_dehydrogenase	116,155	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY NADP|dep|oxidation reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
8527931	1	10-formyltetrahydrofolate	337,362	10-formyltetrahydrofolate_dehydrogenase	116,155	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY NADP|dep|hydrolysis reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
9092577	1	10-formyltetrahydrofolate	300,325	10-formyltetrahydrofolate_dehydrogenase	183,222	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	+|amod|START_ENTITY oxidation|nmod|+ reactions|dep|oxidation catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
9092577	1	10-formyltetrahydrofolate	394,419	10-formyltetrahydrofolate_dehydrogenase	183,222	10-formyltetrahydrofolate	10-formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY reactions|dep|hydrolysis catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|amod|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
14729668	1	10-formyltetrahydrofolate	218,243	10-Formyltetrahydrofolate_dehydrogenase	163,202	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- converts 10-formyltetrahydrofolate , a precursor for nucleotide biosynthesis , to tetrahydrofolate .
17302434	1	10-formyltetrahydrofolate	293,318	10-Formyltetrahydrofolate_dehydrogenase	168,207	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	conversion|nmod|START_ENTITY resulting|nmod|conversion reaction|acl|resulting +|dep|reaction catalyzes|dobj|+ catalyzes|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- catalyzes an NADP + - dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
24747731	3	10-formyltetrahydrofolate	409,434	10-Formyltetrahydrofolate_dehydrogenase	360,399	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	100526683	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 , the only pathway responsible for formate oxidation in methanol intoxication .
25849409	1	10-formyltetrahydrofolate	372,397	10-Formyltetrahydrofolate_dehydrogenase	183,222	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	100526683	Chemical	Gene	converts|xcomp|START_ENTITY enzyme|conj|converts enzyme|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 .
3392008	1	10-formyltetrahydrofolate	182,207	10-Formyltetrahydrofolate_dehydrogenase	86,125	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- EC 1.5.1.6 -RRB- catalyzes the NADP-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
3392008	5	10-formyltetrahydrofolate	977,1002	10-Formyltetrahydrofolate_dehydrogenase	878,917	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY has|dobj|activity has|nsubj|purified purified|amod|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase purified from the mannitol/sucrose/EDTA supernatant has no 10-formyltetrahydrofolate hydrolase activity .
7646059	1	10-formyltetrahydrofolate	193,218	10-Formyltetrahydrofolate_dehydrogenase	83,122	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate .
7929148	1	10-formyltetrahydrofolate	159,184	10-Formyltetrahydrofolate_dehydrogenase	74,113	10-formyltetrahydrofolate	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY catalyzes|dep|oxidation catalyzes|amod|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate .
7822273	1	10-formyltetrahydrofolate	235,260	10-FTHFDH	161,170	10-formyltetrahydrofolate	10-FTHFDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY enzyme|dep|oxidation enzyme|appos|catalyzes catalyzes|amod|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|dep|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
7822273	1	10-formyltetrahydrofolate	331,356	10-FTHFDH	161,170	10-formyltetrahydrofolate	10-FTHFDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY enzyme|dep|hydrolysis enzyme|appos|catalyzes catalyzes|amod|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|dep|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes both the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
8527931	1	10-formyltetrahydrofolate	241,266	10-FTHFDH	157,166	10-formyltetrahydrofolate	10-FTHFDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY NADP|dep|oxidation reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
8527931	1	10-formyltetrahydrofolate	337,362	10-FTHFDH	157,166	10-formyltetrahydrofolate	10-FTHFDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY NADP|dep|hydrolysis reactions|dep|NADP catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-FTHFDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP -LRB- + -RRB- - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
3366769	2	10-formyltetrahydrofolate	526,551	AICAR	717,722	10-formyltetrahydrofolate	AICAR	MESH:C010161	471	Chemical	Gene	H4folate|amod|START_ENTITY reduction|nmod|H4folate marker|conj|reduction marker|conj|deformylation deformylation|acl|dihydrofolate dihydrofolate|nmod|presence presence|nmod|transformylase transformylase|appos|END_ENTITY	Its identity was verified by coelution of this compound with a synthetic marker on high pressure liquid chromatography , its reduction to 10-formyltetrahydrofolate -LRB- H4folate -RRB- in the presence of dihydrofolate reductase , and its enzymatic deformylation to dihydrofolate in the presence of aminoimidazolecarboxamide_ribonucleotide -LRB- AICAR -RRB- transformylase .
9143321	2	10-formyltetrahydrofolate	399,424	AICAR	387,392	10-formyltetrahydrofolate	AICAR	MESH:C010161	471	Chemical	Gene	using|xcomp|START_ENTITY END_ENTITY|acl|using	This reaction involves the formylation of AICAR using 10-formyltetrahydrofolate as the formyl donor .
18848533	1	10-formyltetrahydrofolate	143,168	Aldh1L1	113,120	10-formyltetrahydrofolate	Aldh1L1	MESH:C010161	10840	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|FDH FDH|appos|dehydrogenase dehydrogenase|dep|END_ENTITY	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
18848533	1	10-formyltetrahydrofolate	72,97	Aldh1L1	113,120	10-formyltetrahydrofolate	Aldh1L1	MESH:C010161	10840	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
28414156	1	10-formyltetrahydrofolate	164,189	ALDH1L1	64,71	10-formyltetrahydrofolate	ALDH1L1	MESH:C010161	10840	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nsubj|END_ENTITY	ALDH1L1 , a member of the aldehyde dehydrogenase superfamily of enzymes , catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
20498374	0	10-formyltetrahydrofolate	40,65	ALDH1L2	0,7	10-formyltetrahydrofolate	ALDH1L2	MESH:C010161	160428	Chemical	Gene	dehydrogenase|amod|START_ENTITY homolog|nmod|dehydrogenase homolog|nsubj|END_ENTITY	ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase .
11430769	8	10-formyltetrahydrofolate	1815,1840	C-6	1642,1645	10-formyltetrahydrofolate	C-6	MESH:C010161	729	Chemical	Gene	oxidation|nmod|START_ENTITY withstand|nmod|oxidation withstand|nsubj|dogma dogma|dep|bioactive bioactive|nsubj|dose dose|nmod|isomer isomer|compound|END_ENTITY	The dogma that an oral dose of the unnatural C-6 isomer of 5-formyltetrahydrofolate is not bioactive in human subjects does not withstand scrutiny , most probably due to the previously unrecognized in vivo oxidation of 10-formyltetrahydrofolate .
16597835	4	10-formyltetrahydrofolate	672,697	CO2	725,728	10-formyltetrahydrofolate	CO2	MESH:C010161	717	Chemical	Gene	oxidation|nmod|START_ENTITY activity|dep|oxidation produces|dobj|activity produces|nmod|THF THF|conj|END_ENTITY	Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 .
19933275	4	10-formyltetrahydrofolate	770,795	CO2	820,823	10-formyltetrahydrofolate	CO2	MESH:C010161	717	Chemical	Gene	conversion|nmod|START_ENTITY allows|dobj|conversion allows|nmod|tetrahydrofolate tetrahydrofolate|conj|END_ENTITY	This moiety acts as a swinging arm to couple the activities of the two catalytic domains of FDH and allows the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
28414156	1	10-formyltetrahydrofolate	164,189	CO2	214,217	10-formyltetrahydrofolate	CO2	MESH:C010161	717	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion catalyzes|nmod|tetrahydrofolate tetrahydrofolate|conj|END_ENTITY	ALDH1L1 , a member of the aldehyde dehydrogenase superfamily of enzymes , catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
11556805	1	10-formyltetrahydrofolate	237,262	cytosolic_10-formyltetrahydrofolate_dehydrogenase	83,132	10-formyltetrahydrofolate	cytosolic 10-formyltetrahydrofolate dehydrogenase	MESH:C010161	107747(Tax:10090)	Chemical	Gene	form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|advcl|END_ENTITY	NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc .
11320079	1	10-formyltetrahydrofolate	220,245	FDH	205,208	10-formyltetrahydrofolate	FDH	MESH:C010161	10840	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|enzyme enzyme|appos|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction .
11556805	1	10-formyltetrahydrofolate	237,262	FDH	134,137	10-formyltetrahydrofolate	FDH	MESH:C010161	107747(Tax:10090)	Chemical	Gene	form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|dep|END_ENTITY	NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc .
14729668	1	10-formyltetrahydrofolate	218,243	FDH	204,207	10-formyltetrahydrofolate	FDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- converts 10-formyltetrahydrofolate , a precursor for nucleotide biosynthesis , to tetrahydrofolate .
16597835	4	10-formyltetrahydrofolate	672,697	FDH	604,607	10-formyltetrahydrofolate	FDH	MESH:C010161	10840	Chemical	Gene	oxidation|nmod|START_ENTITY activity|dep|oxidation produces|dobj|activity produces|nsubj|action action|nmod|domains domains|nmod|END_ENTITY	Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 .
17302434	1	10-formyltetrahydrofolate	293,318	FDH	209,212	10-formyltetrahydrofolate	FDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	conversion|nmod|START_ENTITY resulting|nmod|conversion reaction|acl|resulting +|dep|reaction catalyzes|dobj|+ catalyzes|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- catalyzes an NADP + - dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
18848533	1	10-formyltetrahydrofolate	143,168	FDH	67,70	10-formyltetrahydrofolate	FDH	MESH:C010161	10840	Chemical	Gene	converts|xcomp|START_ENTITY converts|nsubj|END_ENTITY	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
18848533	1	10-formyltetrahydrofolate	72,97	FDH	67,70	10-formyltetrahydrofolate	FDH	MESH:C010161	10840	Chemical	Gene	dehydrogenase|amod|START_ENTITY END_ENTITY|appos|dehydrogenase	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
19933275	4	10-formyltetrahydrofolate	770,795	FDH	737,740	10-formyltetrahydrofolate	FDH	MESH:C010161	10840	Chemical	Gene	conversion|nmod|START_ENTITY allows|dobj|conversion acts|conj|allows acts|dobj|activities activities|nmod|domains domains|nmod|END_ENTITY	This moiety acts as a swinging arm to couple the activities of the two catalytic domains of FDH and allows the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 .
25849409	1	10-formyltetrahydrofolate	372,397	FDH	224,227	10-formyltetrahydrofolate	FDH	MESH:C010161	100526683	Chemical	Gene	converts|xcomp|START_ENTITY enzyme|conj|converts enzyme|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 .
9092577	1	10-formyltetrahydrofolate	300,325	FDH	224,227	10-formyltetrahydrofolate	FDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	+|amod|START_ENTITY oxidation|nmod|+ reactions|dep|oxidation catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
9092577	1	10-formyltetrahydrofolate	394,419	FDH	224,227	10-formyltetrahydrofolate	FDH	MESH:C010161	64392(Tax:10116)	Chemical	Gene	hydrolysis|nmod|START_ENTITY reactions|dep|hydrolysis catalyzes|dobj|reactions catalyzes|nsubj|cytosolic cytosolic|appos|END_ENTITY	The liver cytosolic enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- -LRB- EC 1.5.1.6 -RRB- catalyzes two reactions : the NADP + - dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP + - independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate .
3196754	0	10-formyltetrahydrofolate	18,43	folate_binding_protein	79,101	10-formyltetrahydrofolate	folate binding protein	MESH:C010161	25134(Tax:10116)	Chemical	Gene	dehydrogenase-hydrolase|amod|START_ENTITY Identification|nmod|dehydrogenase-hydrolase Identification|nmod|END_ENTITY	Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate_binding_protein in liver cytosol .
985432	17	10-formyltetrahydrofolate	1787,1812	formyltetrahydrofolate_dehydrogenase	1877,1913	10-formyltetrahydrofolate	formyltetrahydrofolate dehydrogenase	MESH:C010161	64392(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY causes|dobj|increase causes|dep|accelerates accelerates|dobj|reaction reaction|amod|END_ENTITY	18B , 793-798 -RSB- , that this inhibition causes an increase in the concentration of methylenetetrahydrofolate and the C1_tetrahydrofolate derivatives in equilibrium with methylenetetrahydrofolate , including 10-formyltetrahydrofolate ; that the increased concentration of the latter accelerates the formyltetrahydrofolate_dehydrogenase reaction , because the normal concentration of the substrate is far below the Km value of the enzyme for the substrate .
19007868	4	10-formyltetrahydrofolate	914,939	GART	883,887	10-formyltetrahydrofolate	GART	MESH:C010161	100689446	Chemical	Gene	requires|xcomp|START_ENTITY requires|nsubj|activity activity|amod|END_ENTITY	The GART activity of GART requires 10-formyltetrahydrofolate and has been a target for anti-cancer drugs .
19007868	4	10-formyltetrahydrofolate	914,939	GART	900,904	10-formyltetrahydrofolate	GART	MESH:C010161	100689446	Chemical	Gene	requires|xcomp|START_ENTITY requires|nsubj|activity activity|nmod|END_ENTITY	The GART activity of GART requires 10-formyltetrahydrofolate and has been a target for anti-cancer drugs .
25633902	1	10-formyltetrahydrofolate	331,356	MTHFD1	172,178	10-formyltetrahydrofolate	MTHFD1	MESH:C010161	4522	Chemical	Gene	activity|amod|START_ENTITY dehydrogenase|conj|activity containing|dobj|dehydrogenase enzyme|acl|containing enzyme|nmod|END_ENTITY	UNASSIGNED : In the folate cycle MTHFD1 , encoded by MTHFD1 , is a trifunctional enzyme containing 5,10-methylenetetrahydrofolate dehydrogenase , 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activity .
25633902	1	10-formyltetrahydrofolate	331,356	MTHFD1	191,197	10-formyltetrahydrofolate	MTHFD1	MESH:C010161	4522	Chemical	Gene	activity|amod|START_ENTITY dehydrogenase|conj|activity containing|dobj|dehydrogenase enzyme|acl|containing enzyme|dep|encoded encoded|nmod|END_ENTITY	UNASSIGNED : In the folate cycle MTHFD1 , encoded by MTHFD1 , is a trifunctional enzyme containing 5,10-methylenetetrahydrofolate dehydrogenase , 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activity .
19022216	5	10-formyltetrahydrofolate	867,892	MTHFS	831,836	10-formyltetrahydrofolate	MTHFS	MESH:C010161	10588	Chemical	Gene	availability|nmod|START_ENTITY increases|dobj|availability increases|nsubj|END_ENTITY	This finding supports a mechanism whereby MTHFS increases the availability of 10-formyltetrahydrofolate for GARFT .
12024029	3	10-formyltetrahydrofolate	568,593	NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase	398,491	10-formyltetrahydrofolate	NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase	MESH:C010161	10797	Chemical	Gene	5,10-methylenetetrahydrofolate|conj|START_ENTITY interconversion|acl|5,10-methylenetetrahydrofolate catalyzes|dobj|interconversion catalyzes|nsubj|END_ENTITY	NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase -LRB- NMDMC -RRB- catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells , but its metabolic role is not yet clear .
11556805	1	10-formyltetrahydrofolate	237,262	NEUT2	55,60	10-formyltetrahydrofolate	NEUT2	MESH:C010161	107747(Tax:10090)	Chemical	Gene	form|nmod|START_ENTITY units|nmod|form oxidation|nmod|units catalyzes|dobj|oxidation deficient|ccomp|catalyzes deficient|nsubj|mice mice|compound|END_ENTITY	NEUT2 mice are deficient in cytosolic_10-formyltetrahydrofolate_dehydrogenase -LRB- FDH ; EC 1.5.1.6 -RRB- which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO -LRB- 2 -RRB- and tetrahydrofolate -LRB- Champion et al. , Proc .
12024029	11	10-formyltetrahydrofolate	1675,1700	NMDMC	1655,1660	10-formyltetrahydrofolate	NMDMC	MESH:C010161	17768(Tax:10090)	Chemical	Gene	provide|xcomp|START_ENTITY provide|nsubj|role role|acl|postulated postulated|nmod|END_ENTITY	One role postulated for NMDMC is to provide 10-formyltetrahydrofolate as a formyl group donor for the synthesis of this formylmethionyl-tRNA -LRB- fmet -RRB- .
12024029	3	10-formyltetrahydrofolate	568,593	NMDMC	493,498	10-formyltetrahydrofolate	NMDMC	MESH:C010161	10797	Chemical	Gene	5,10-methylenetetrahydrofolate|conj|START_ENTITY interconversion|acl|5,10-methylenetetrahydrofolate catalyzes|dobj|interconversion catalyzes|nsubj|NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase|appos|END_ENTITY	NAD-dependent_methylenetetrahydrofolate_dehydrogenase-methenyltetrahydrofolate_cyclohydrolase -LRB- NMDMC -RRB- catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells , but its metabolic role is not yet clear .
1848231	9	10-formyltetrahydrofolate	1249,1274	phosphoribosylglycinamide_formyltransferase	1166,1209	10-formyltetrahydrofolate	phosphoribosylglycinamide formyltransferase	MESH:C010161	288259(Tax:10116)	Chemical	Gene	region|nmod|START_ENTITY proposed|nsubjpass|region discussed|conj|proposed discussed|nsubjpass|identity identity|nmod|END_ENTITY	The sequence identity to phosphoribosylglycinamide_formyltransferase is discussed , and a binding region for 10-formyltetrahydrofolate is proposed .
3734324	1	10-formyltetrahydrofolate	139,164	thymidylate_synthase	288,308	10-formyltetrahydrofolate	thymidylate synthase	MESH:C010161	22171(Tax:10090)	Chemical	Gene	determination|nmod|START_ENTITY method|nmod|determination described|nsubjpass|method described|advcl|complex complex|acl|formed formed|nmod|methylenetetrahydrofolate methylenetetrahydrofolate|conj|END_ENTITY	A radioenzymatic method for the determination of tissue 10-formyltetrahydrofolate is described based on the stable ternary complex formed from methylenetetrahydrofolate , tritiated_fluorodeoxyuridylate and thymidylate_synthase .
9749667	3	10-formyl_tetrahydrofolate	462,488	Bas2p	626,631	10-formyl tetrahydrofolate	Bas2p	MESH:C010161	851452(Tax:4932)	Chemical	Gene	glutamine|conj|START_ENTITY shows|amod|glutamine synthesis|nmod|shows required|nmod|synthesis required|ccomp|repressed repressed|conj|requires requires|dobj|Baslp Baslp|conj|END_ENTITY	Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p .
9749667	3	10-formyl_tetrahydrofolate	462,488	MTD1	505,509	10-formyl tetrahydrofolate	MTD1	MESH:C010161	853955(Tax:4932)	Chemical	Gene	glutamine|conj|START_ENTITY shows|amod|glutamine shows|dep|GLN1 GLN1|conj|END_ENTITY	Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p .
9749667	3	10-formyl_tetrahydrofolate	462,488	SHM2	496,500	10-formyl tetrahydrofolate	SHM2	MESH:C010161	850747(Tax:4932)	Chemical	Gene	glutamine|conj|START_ENTITY shows|amod|glutamine shows|dep|GLN1 GLN1|conj|END_ENTITY	Analysis of three genes required for synthesis of glutamine , glycine and 10-formyl_tetrahydrofolate -LRB- GLN1 , SHM2 and MTD1 , respectively -RRB- shows that their expression is repressed by adenine and requires the transcription factors Baslp and Bas2p .
889710	6	10-formyl-tetrahydrofolate	843,869	peak_2	800,806	10-formyl-tetrahydrofolate	peak 2	MESH:C010161	157285	Chemical	Gene	represent|xcomp|START_ENTITY unknown|conj|represent unknown|nsubj|nature nature|nmod|END_ENTITY	The nature of peak_2 is unknown but peak 3 may represent 10-formyl-tetrahydrofolate .
21238436	1	10-Formyltetrahydrofolate	90,115	aldehyde_dehydrogenase	256,278	10-Formyltetrahydrofolate	aldehyde dehydrogenase	MESH:C010161	17035736	Chemical	Gene	dehydrogenase|amod|START_ENTITY shares|nsubj|dehydrogenase shares|nmod|enzymes enzymes|nmod|family family|amod|END_ENTITY	10-Formyltetrahydrofolate dehydrogenase -LRB- FDH , ALDH1L1 -RRB- , an abundant cytosolic enzyme of folate metabolism , shares significant sequence similarity with enzymes of the aldehyde_dehydrogenase -LRB- ALDH -RRB- family .
21238436	1	10-Formyltetrahydrofolate	90,115	ALDH	280,284	10-Formyltetrahydrofolate	ALDH	MESH:C010161	17035736	Chemical	Gene	dehydrogenase|amod|START_ENTITY shares|nsubj|dehydrogenase shares|nmod|enzymes enzymes|nmod|family family|appos|END_ENTITY	10-Formyltetrahydrofolate dehydrogenase -LRB- FDH , ALDH1L1 -RRB- , an abundant cytosolic enzyme of folate metabolism , shares significant sequence similarity with enzymes of the aldehyde_dehydrogenase -LRB- ALDH -RRB- family .
27404357	7	10-formyl-tetrahydrofolate-Glun_and_dihydropteroate	952,1003	FOLR-1	896,902	10-formyl-tetrahydrofolate-Glun and dihydropteroate	FOLR-1	null	182740(Tax:6239)	Chemical	Gene	required|advcl|START_ENTITY required|nsubjpass|END_ENTITY	The folate receptor homolog FOLR-1 is required for the stimulation of germ cells by 10-formyl-tetrahydrofolate-Glun_and_dihydropteroate .
1989499	0	10-formyltetrahydropteroylpolyglutamate	48,87	thymidylate_synthase	24,44	10-formyltetrahydropteroylpolyglutamate	thymidylate synthase	null	7298	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mammalian thymidylate_synthase by 10-formyltetrahydropteroylpolyglutamate .
16365037	10	10-formylTHF	1498,1510	MTHFS	1426,1431	10-formylTHF	MTHFS	CHEBI:15637	10588	Chemical	Gene	facilitates|amod|START_ENTITY indicating|dobj|facilitates biosynthesis|xcomp|indicating enhances|ccomp|biosynthesis enhances|nsubj|END_ENTITY	Isotope tracer studies in neuroblastoma demonstrate that MTHFS enhances de novo purine biosynthesis , indicating that MTHFS-bound 10-formylTHF facilitates de novo purine biosynthesis .
16365037	11	10-formylTHF	1594,1606	MTHFS	1585,1590	10-formylTHF	MTHFS	CHEBI:15637	10588	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF , providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells .
16365037	11	10-formylTHF	1673,1685	MTHFS	1585,1590	10-formylTHF	MTHFS	CHEBI:15637	10588	Chemical	Gene	presence|nmod|START_ENTITY accumulate|nmod|presence indicates|ccomp|accumulate indicates|nsubj|regulation regulation|nmod|END_ENTITY	Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF , providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells .
16365037	12	10-formylTHF	1821,1833	MTHFS	1837,1842	10-formylTHF	MTHFS	CHEBI:15637	10588	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	The sequestration of 10-formylTHF by MTHFS may explain why de novo purine biosynthesis is protected from common disruptions in the folate-dependent one-carbon network .
16365037	7	10-formylTHF	1047,1059	MTHFS	1164,1169	10-formylTHF	MTHFS	CHEBI:15637	107885(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|inhibitor inhibitor|nmod|END_ENTITY	Steady-state kinetic studies revealed that 10-formylTHF , which exists in chemical equilibrium with 5,10-methenylTHF , acts as a tight binding inhibitor of mouse MTHFS .
16365037	9	10-formylTHF	1333,1345	MTHFS	1303,1308	10-formylTHF	MTHFS	CHEBI:15637	10588	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	MTHFS is the first identified 10-formylTHF tight-binding protein .
22303332	13	10-formylTHF	2153,2165	MTHFS	2104,2109	10-formylTHF	MTHFS	CHEBI:15637	107885(Tax:10090)	Chemical	Gene	delivering|xcomp|START_ENTITY enhances|advcl|delivering enhances|nsubj|END_ENTITY	The results from this study indicate that MTHFS enhances purine biosynthesis by delivering 10-formylTHF to the purinosome in a SUMO-dependent fashion .
11320079	1	10-formyl-THF	247,260	10-formyltetrahydrofolate_dehydrogenase	164,203	10-formyl-THF	10-formyltetrahydrofolate dehydrogenase	CHEBI:15637	10840	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|enzyme enzyme|appos|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction .
7972060	3	10-formyl-THF	565,578	10-formyltetrahydrofolate_dehydrogenase	524,563	10-formyl-THF	10-formyltetrahydrofolate dehydrogenase	CHEBI:15637	107747(Tax:10090)	Chemical	Gene	DH|amod|START_ENTITY identified|dep|DH identified|nmod|forms forms|nmod|END_ENTITY	Characterization of this protein_deficiency has identified these liver proteins as forms of the enzyme 10-formyltetrahydrofolate_dehydrogenase -LRB- 10-formyl-THF DH ; 10-formyltetrahydrofolate : NADP + oxidoreductase , EC 1.5.1.6 -RRB- .
2233711	6	10-formyl-THF	1183,1196	ade3	1214,1218	10-formyl-THF	ade3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	synthetase|amod|START_ENTITY synthetase|nmod|strain strain|amod|END_ENTITY	Heterologous expression of the Clostridium_acidiurici gene encoding a monofunctional 10-formyl-THF synthetase in an ade3 deletion strain did not restore growth in the absence of adenine , even though the monofunctional synthetase was catalytically competent in vivo .
8608153	5	10-formyl-THF	1082,1095	ade3	1178,1182	10-formyl-THF	ade3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	levels|nmod|START_ENTITY revealed|dobj|levels used|ccomp|revealed used|nmod|strain strain|amod|END_ENTITY	Direct measurements of cellular folate coenzyme levels revealed substantial levels of 10-formyl-THF -LRB- CHO-THF -RRB- , the one-carbon donor used in purine synthesis , in the purine-requiring ade3 deletion strain .
2233711	2	10-formyl-THF	580,593	ADE3	460,464	10-formyl-THF	ADE3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	donor|amod|START_ENTITY synthesis|nmod|donor responsible|nmod|synthesis responsible|nsubj|enzyme enzyme|acl|encoded encoded|nmod|gene gene|compound|END_ENTITY	This trifunctional enzyme , encoded by the ADE3 gene in the yeast Saccharomyces_cerevisiae , is thought to be responsible for the synthesis of the one-carbon donor 10-formyl-THF for de novo purine synthesis .
2233711	3	10-formyl-THF	727,740	ADE3	640,644	10-formyl-THF	ADE3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	lack|nmod|START_ENTITY result|nmod|lack causes|nmod|result causes|nsubj|Deletion Deletion|nmod|gene gene|compound|END_ENTITY	Deletion of the ADE3 gene causes adenine auxotrophy , presumably as a result of the lack of cytoplasmic 10-formyl-THF .
2679653	8	10-formyl-THF	1328,1341	ADE3	1236,1240	10-formyl-THF	ADE3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	synthetase|amod|START_ENTITY encoding|dobj|synthetase encoding|advcl|encoding shown|xcomp|encoding shown|nmod|gene gene|compound|END_ENTITY	The feasibility and versatility of the method is shown with the yeast ADE3 gene encoding the cytoplasmic C1-THF synthase and the gene encoding the monofunctional 10-formyl-THF synthetase from Clostridium_acidiurici .
8464869	1	10-formyl-THF	240,253	ADE3	87,91	10-formyl-THF	ADE3	CHEBI:15637	853118(Tax:4932)	Chemical	Gene	synthetase|amod|START_ENTITY possesses|dobj|synthetase synthase|acl:relcl|possesses identified|nmod|synthase identified|nsubjpass|product product|nmod|gene gene|compound|END_ENTITY	The protein product of the ADE3 gene of the yeast Saccharomyces_cerevisiae has been identified as the cytoplasmic trifunctional C1-tetrahydrofolate -LRB- THF -RRB- synthase , which possesses 10-formyl-THF synthetase -LRB- EC 6.3.4.3 -RRB- , 5,10-methenyl-THF cyclohydrolase -LRB- EC 3.5.4.9 -RRB- , and 5,10-methylene-THF dehydrogenase -LRB- EC 1.5.1.5 -RRB- activities .
18848533	1	10-formyl-THF	170,183	Aldh1L1	113,120	10-formyl-THF	Aldh1L1	MESH:C006461	10840	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|FDH FDH|appos|dehydrogenase dehydrogenase|dep|END_ENTITY	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
16597835	4	10-formyl-THF	699,712	CO2	725,728	10-formyl-THF	CO2	CHEBI:15637	717	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate activity|dep|oxidation produces|dobj|activity produces|nmod|THF THF|conj|END_ENTITY	Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 .
26567272	5	10-formyl-THF	739,752	CO2	867,870	10-formyl-THF	CO2	CHEBI:15637	717	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|acl:relcl|oxidizes oxidizes|nmod|END_ENTITY	The key enzyme for these mechanisms is 10-formyl-THF -LRB- tetrahydrofolate -RRB- dehydrogenase -LRB- both mitochondrial and cytoplasmic isoforms -RRB- which oxidizes the formyl group to CO2 with the attendant reduction of NADP -LRB- + -RRB- to NADPH and release of THF .
11320079	1	10-formyl-THF	247,260	FDH	205,208	10-formyl-THF	FDH	CHEBI:15637	10840	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|enzyme enzyme|appos|10-formyltetrahydrofolate_dehydrogenase 10-formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	The enzyme , 10-formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate in an NADP -LRB- + -RRB- - dependent dehydrogenase reaction or an NADP -LRB- + -RRB- - independent hydrolase reaction .
11320079	3	10-formyl-THF	639,652	FDH	568,571	10-formyl-THF	FDH	CHEBI:15637	10840	Chemical	Gene	utilizing|xcomp|START_ENTITY enzymes|acl|utilizing shares|nmod|enzymes shares|nsubj|domain domain|nmod|END_ENTITY	The amino-terminal domain of FDH shares some sequence identity with several other enzymes utilizing 10-formyl-THF as a substrate .
16597835	3	10-formyl-THF	511,524	FDH	442,445	10-formyl-THF	FDH	CHEBI:15637	10840	Chemical	Gene	utilize|xcomp|START_ENTITY homolog|acl:relcl|utilize homolog|nsubj|domain domain|nmod|END_ENTITY	The amino-terminal hydrolase domain of FDH -LRB- Nt-FDH -RRB- is a homolog of formyl transferase enzymes that utilize 10-formyl-THF as a formyl donor .
16597835	4	10-formyl-THF	699,712	FDH	604,607	10-formyl-THF	FDH	CHEBI:15637	10840	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate activity|dep|oxidation produces|dobj|activity produces|nsubj|action action|nmod|domains domains|nmod|END_ENTITY	Interestingly , the concerted action of all three domains of FDH produces a new catalytic activity , NADP + - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to THF and CO2 .
16627483	8	10-formyl-THF	1663,1676	FDH	1457,1460	10-formyl-THF	FDH	CHEBI:15637	10840	Chemical	Gene	conversion|nmod|START_ENTITY catalyzing|dobj|conversion deplete|advcl|catalyzing facilitates|advcl|deplete facilitates|nsubj|expression expression|compound|END_ENTITY	We conclude that low FDH expression facilitates the incorporation of one-carbon units into the one-carbon pool , whereas high levels of FDH expression deplete the folate-activated one-carbon pool by catalyzing the conversion of 10-formyl-THF to THF .
18848533	1	10-formyl-THF	170,183	FDH	67,70	10-formyl-THF	FDH	MESH:C006461	10840	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate converts|nsubj|END_ENTITY	FDH -LRB- 10-formyltetrahydrofolate dehydrogenase , Aldh1L1 , EC 1.5.1.6 -RRB- converts 10-formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- to tetrahydrofolate and CO -LRB- 2 -RRB- in a NADP -LRB- + -RRB- - dependent reaction .
10781559	4	10-formyl-THF	810,823	FMT1	906,910	10-formyl-THF	FMT1	CHEBI:15637	852270(Tax:4932)	Chemical	Gene	synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|methionyl-tRNA_formyltransferase methionyl-tRNA_formyltransferase|appos|YBL013W YBL013W|dep|END_ENTITY	We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- .
10781559	3	10-formyl-THF	594,607	methionyl-tRNA_formyltransferase	492,524	10-formyl-THF	methionyl-tRNA formyltransferase	CHEBI:15637	852270(Tax:4932)	Chemical	Gene	formyltetrahydrofolate|dep|START_ENTITY N|dep|formyltetrahydrofolate uses|dobj|N catalyzed|conj|uses catalyzed|nmod|END_ENTITY	The formylation reaction is catalyzed by methionyl-tRNA_formyltransferase -LRB- MTF -RRB- located in mitochondria and uses N -LRB- 10 -RRB- - formyltetrahydrofolate -LRB- 10-formyl-THF -RRB- as the formyl donor .
10781559	4	10-formyl-THF	810,823	methionyl-tRNA_formyltransferase	833,865	10-formyl-THF	methionyl-tRNA formyltransferase	CHEBI:15637	852270(Tax:4932)	Chemical	Gene	synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|END_ENTITY	We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- .
10781559	4	10-formyl-THF	810,823	MIS1	776,780	10-formyl-THF	MIS1	CHEBI:15637	852378(Tax:4932)	Chemical	Gene	synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|appos|END_ENTITY	We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- .
19033438	2	10-formyl-THF	523,536	Mthfd1	350,356	10-formyl-THF	Mthfd1	CHEBI:15637	108156(Tax:10090)	Chemical	Gene	catalyzes|nmod|START_ENTITY point|acl:relcl|catalyzes point|nsubj|synthase synthase|acl|encoded encoded|nmod|END_ENTITY	C1_tetrahydrofolate _ -LRB- THF -RRB- _ synthase , encoded by Mthfd1 , is an entry point of 1Cs into folate metabolism through its formyl-THF synthetase -LRB- FTHFS -RRB- activity that catalyzes the ATP-dependent conversion of formate and THF to 10-formyl-THF .
19948730	5	10-formyl-THF	881,894	MTHFD1L	907,914	10-formyl-THF	MTHFD1L	MESH:C006461	270685(Tax:10090)	Chemical	Gene	synthetase|amod|START_ENTITY synthetase|appos|product product|nummod|END_ENTITY	A monofunctional 10-formyl-THF synthetase -LRB- MTHFD1L gene product -RRB- functions in adult mitochondria and is a likely candidate for the embryonic activity .
23267094	5	10-formyl-THF	855,868	MTHFD1L	736,743	10-formyl-THF	MTHFD1L	CHEBI:15637	270685(Tax:10090)	Chemical	Gene	producing|advcl|START_ENTITY catalyzes|advcl|producing catalyzes|nsubj|END_ENTITY	In both embryos and adults , MTHFD1L catalyzes the last step in the flow of one-carbon units from mitochondria to cytoplasm , producing formate from 10-formyl-THF .
16597835	3	10-formyl-THF	511,524	Nt-FDH	447,453	10-formyl-THF	Nt-FDH	CHEBI:15637	10840	Chemical	Gene	utilize|xcomp|START_ENTITY homolog|acl:relcl|utilize homolog|nsubj|domain domain|appos|END_ENTITY	The amino-terminal hydrolase domain of FDH -LRB- Nt-FDH -RRB- is a homolog of formyl transferase enzymes that utilize 10-formyl-THF as a formyl donor .
16597835	6	10-formyl-THF	1087,1100	Nt-FDH	1068,1074	10-formyl-THF	Nt-FDH	CHEBI:15637	10840	Chemical	Gene	enzymes|amod|START_ENTITY enzymes|compound|END_ENTITY	The second was to explore the molecular basis for the distinct catalytic mechanisms of Nt-FDH and related 10-formyl-THF utilizing enzymes .
10781559	4	10-formyl-THF	810,823	YBL013W	886,893	10-formyl-THF	YBL013W	CHEBI:15637	852270(Tax:4932)	Chemical	Gene	synthesis|nmod|START_ENTITY necessary|nmod|synthesis synthase|amod|necessary synthase|conj|methionyl-tRNA_formyltransferase methionyl-tRNA_formyltransferase|appos|END_ENTITY	We have studied yeast mutants carrying chromosomal disruptions of the genes encoding the mitochondrial C -LRB- 1 -RRB- - tetrahydrofolate -LRB- C -LRB- 1 -RRB- - THF -RRB- synthase -LRB- MIS1 -RRB- , necessary for synthesis of 10-formyl-THF , and the methionyl-tRNA_formyltransferase -LRB- open reading frame YBL013W ; designated FMT1 -RRB- .
25849409	1	10-FTHF	399,406	10-Formyltetrahydrofolate_dehydrogenase	183,222	10-FTHF	10-Formyltetrahydrofolate dehydrogenase	MESH:C010161	100526683	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate enzyme|conj|converts enzyme|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 .
25849409	1	10-FTHF	399,406	FDH	224,227	10-FTHF	FDH	MESH:C010161	100526683	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY converts|xcomp|10-formyltetrahydrofolate enzyme|conj|converts enzyme|nsubj|10-Formyltetrahydrofolate_dehydrogenase 10-Formyltetrahydrofolate_dehydrogenase|appos|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- FDH -RRB- , which is composed of a small N-terminal domain -LRB- Nt-FDH -RRB- and a large C-terminal domain , is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate -LRB- 10-FTHF -RRB- to tetrahydrofolate -LRB- THF -RRB- and CO2 .
24962868	7	10G	1293,1296	STAT3	1346,1351	10G	STAT3	null	6774	Chemical	Gene	10-gingerol|appos|START_ENTITY 6-gingerol|conj|10-gingerol analogues|nmod|6-gingerol found|advcl|analogues found|xcomp|blocker blocker|nmod|activation activation|compound|END_ENTITY	Compared with other analogues of 6SG , such as 6-gingerol -LRB- 6G -RRB- , 8-gingerol -LRB- 8G -RRB- , and 10-gingerol -LRB- 10G -RRB- , 6SG was found to be the most potent blocker of STAT3 activation .
15068071	1	10_g_alpha-lactalbumin	266,288	alpha-lactalbumin	139,156	10 g alpha-lactalbumin	alpha-lactalbumin	MESH:C506422	281894(Tax:9913)	Chemical	Gene	/|amod|START_ENTITY solutions|nmod|/ incubation|nmod|solutions investigated|nmod|incubation investigated|nsubjpass|Details Details|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	Details in the hydrolysis of alpha-lactalbumin known to result in formation of highly ordered nanotubules , was investigated by incubation of solutions with 10_g_alpha-lactalbumin / l with a specific protease from Bacillus_licheniformis -LRB- BLP -RRB- .
22761764	9	10-gingerol	1396,1407	bmp2b	1464,1469	10-gingerol	bmp2b	MESH:C007845	30632(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|nmod|expression expression|amod|END_ENTITY	We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 .
22761764	9	10-gingerol	1396,1407	bmp7a	1474,1479	10-gingerol	bmp7a	MESH:C007845	30584(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|nmod|expression expression|amod|bmp2b bmp2b|conj|END_ENTITY	We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 .
17561453	3	10-gingerol	602,613	C-8	714,717	10-gingerol	C-8	MESH:C007845	3224	Chemical	Gene	6-Gingerol|conj|START_ENTITY extracted|csubjpass|6-Gingerol extracted|conj|analyzed analyzed|nmod|column column|amod|reversed reversed|amod|END_ENTITY	6-Gingerol , 6-shogaol , 8-gingerol , and 10-gingerol were extracted from various ginger-containing products with ethyl_acetate and analyzed by HPLC on a C-8 reversed phase column at 282 nm .
20837112	5	10-gingerol	676,687	COX-1	736,741	10-gingerol	COX-1	MESH:C007845	4512	Chemical	Gene	inhibit|dep|START_ENTITY inhibit|xcomp|END_ENTITY	Therefore , 10-gingerol , 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1 , which can explain , in part , the anti-inflammatory properties of ginger .
20837112	3	10-gingerol	511,522	COX-2	559,564	10-gingerol	COX-2	MESH:C007845	4513	Chemical	Gene	Purified|xcomp|START_ENTITY Purified|dep|inhibited inhibited|dobj|values values|amod|END_ENTITY	Purified 10-gingerol , 8-shogaol and 10-shogaol inhibited COX-2 with IC -LRB- 50 -RRB- values of 32 M , 17.5 M and 7.5 M , respectively .
20837112	5	10-gingerol	676,687	COX-2	722,727	10-gingerol	COX-2	MESH:C007845	4513	Chemical	Gene	inhibit|dep|START_ENTITY inhibit|xcomp|COX-1 COX-1|dep|END_ENTITY	Therefore , 10-gingerol , 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1 , which can explain , in part , the anti-inflammatory properties of ginger .
23770984	8	10-gingerol	1141,1152	CYP3A4	1206,1212	10-gingerol	CYP3A4	MESH:C007845	1576	Chemical	Gene	8-gingerol|conj|START_ENTITY inhibited|dep|8-gingerol inhibited|conj|induced induced|dobj|expression expression|nmod|END_ENTITY	In HepG2 cells , 8-gingerol and 10-gingerol inhibited , but 6-gingerol induced mRNA expression of CYP3A4 .
22761764	9	10-gingerol	1396,1407	eve1	1534,1538	10-gingerol	eve1	MESH:C007845	30335(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|conj|effectors effectors|conj|END_ENTITY	We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 .
22761764	6	10-gingerol	957,968	gata1	804,809	10-gingerol	gata1	MESH:C007845	30481(Tax:7955)	Chemical	Gene	component|amod|START_ENTITY identified|dobj|component utilized|conj|identified utilized|dobj|END_ENTITY	METHODOLOGY/PRINCIPAL FINDINGS : Here , we utilized gata1 : dsRed transgenic zebrafish embryos to investigate the effect of ginger extract on hematopoiesis in vivo and we identified its bioactive component , 10-gingerol .
22761764	7	10-gingerol	999,1010	gata1	1037,1042	10-gingerol	gata1	MESH:C007845	30481(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY promote|nsubj|ginger promote|dobj|expression expression|nmod|END_ENTITY	We confirmed that ginger and 10-gingerol promote the expression of gata1 in erythroid cells and increase the expression of hematopoietic progenitor markers cmyb and scl .
22761764	9	10-gingerol	1396,1407	gata2	1524,1529	10-gingerol	gata2	MESH:C007845	30480(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY treatment|compound|ginger found|dobj|treatment found|nmod|increase increase|conj|effectors effectors|conj|END_ENTITY	We found that ginger and 10-gingerol treatment during gastrulation results in an increase of bmp2b and bmp7a expression , and their downstream effectors , gata2 and eve1 .
21846463	5	10-gingerol	636,647	ghrelin	689,696	10-gingerol	ghrelin	MESH:C007845	59301(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|deacylation deacylation|compound|END_ENTITY	In addition , 10-gingerol , a component of RKT , inhibited exogenous ghrelin deacylation .
28872603	9	10-gingerol	1180,1191	GST	1298,1301	10-gingerol	GST	MESH:C007845	373156	Chemical	Gene	6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|MRP1 MRP1|conj|END_ENTITY	Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression .
22761764	10	10-gingerol	1567,1578	lmo2	1614,1618	10-gingerol	lmo2	MESH:C007845	30332(Tax:7955)	Chemical	Gene	ginger|conj|START_ENTITY stages|amod|ginger induce|nsubj|stages induce|dobj|expression expression|compound|scl scl|conj|END_ENTITY	At later stages ginger and 10-gingerol can induce bmp2b/7a , cmyb , scl and lmo2 expression in the caudal hematopoietic tissue area .
28872603	9	10-gingerol	1180,1191	MRP1	1289,1293	10-gingerol	MRP1	MESH:C007845	4363	Chemical	Gene	6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression .
22540971	8	10-gingerol	1246,1257	NK1	1332,1335	10-gingerol	NK1	MESH:C007845	6869	Chemical	Gene	6-gingerol|conj|START_ENTITY phytochemicals|amod|6-gingerol function|nsubj|phytochemicals function|xcomp|antihistaminic antihistaminic|nsubj|antagonist antagonist|appos|antagonist antagonist|nummod|END_ENTITY	The exact mechanism responsible for the anti-emetic effects of ginger is unknown ; however , the ginger phytochemicals , especially 6-gingerol , 8-gingerol , 10-gingerol , and 6-shogaol , may function as a 5-hydroxytryptamine -LRB- 5-HT3 -RRB- antagonist , NK1 antagonist , antihistaminic , and possess prokinetic effects .
28872603	6	10-gingerol	742,753	PC3	934,937	10-gingerol	PC3	MESH:C007845	5122	Chemical	Gene	M|amod|START_ENTITY inhibited|nsubj|M inhibited|ccomp|displayed displayed|nmod|END_ENTITY	6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 .
24962868	7	10-gingerol	1280,1291	STAT3	1346,1351	10-gingerol	STAT3	MESH:C007845	6774	Chemical	Gene	6-gingerol|conj|START_ENTITY analogues|nmod|6-gingerol found|advcl|analogues found|xcomp|blocker blocker|nmod|activation activation|compound|END_ENTITY	Compared with other analogues of 6SG , such as 6-gingerol -LRB- 6G -RRB- , 8-gingerol -LRB- 8G -RRB- , and 10-gingerol -LRB- 10G -RRB- , 6SG was found to be the most potent blocker of STAT3 activation .
26554741	0	10-Gingerol	0,11	Akt	105,108	10-Gingerol	Akt	MESH:C007845	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|suppression suppression|nmod|END_ENTITY	10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast_cancer cells through suppression of Akt and p38MAPK activity .
21846463	0	10-Gingerol	0,11	ghrelin	100,107	10-Gingerol	ghrelin	MESH:C007845	59301(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|advcl|inhibiting inhibiting|dobj|degradation degradation|compound|END_ENTITY	10-Gingerol , a component of rikkunshito , improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation .
12010066	1	10H	644,647	scFv	631,635	10H	scFv	null	652070	Chemical	Gene	tri|dobj|START_ENTITY tri|nsubj|+ +|compound|END_ENTITY	Arrhenius activation parameters -LRB- E -LRB- a -RRB- and A -RRB- are reported for the loss of 1 and a series of monodeoxy_trisaccharide congeners -LRB- 5-8 identical with tri -RRB- from the -LRB- scFv + tri + 10H -RRB- -LRB- +10 -RRB- complex .
12010066	2	10H	768,771	scFv	757,761	10H	scFv	null	652070	Chemical	Gene	+|dep|START_ENTITY +|dep|+ +|compound|END_ENTITY	The energetic contribution of the specific oligosaccharide OH groups to the stability of the -LRB- scFv + 1 + 10H -RRB- -LRB- +10 -RRB- complex is determined from the differences in E -LRB- a -RRB- measured for the trisaccharide analogues and 1 -LRB- 55.2 kcal/mol -RRB- .
28740028	9	10H2DA	1109,1115	adiponectin	1151,1162	10H2DA	adiponectin	null	11450(Tax:10090)	Chemical	Gene	enhanced|nsubj|START_ENTITY enhanced|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Furthermore , 10H2DA neither enhanced the expression of adiponectin receptor mRNA nor activated the insulin signaling cascade , such as GSK-3b phosphorylation , in the liver .
21850473	10	10H2DA	1409,1415	CTGF	1351,1355	10H2DA	CTGF	null	1490	Chemical	Gene	down-regulate|nsubj|START_ENTITY suggest|conj|down-regulate suggest|ccomp|factor factor|nsubj|END_ENTITY	These results suggest that CTGF is a regulator factor in the expression of MMPs , and 10H2DA down-regulate the concentration of MMPs probably by down-regulating the expression of CTGF .
21850473	10	10H2DA	1409,1415	CTGF	1502,1506	10H2DA	CTGF	null	1490	Chemical	Gene	down-regulate|nsubj|START_ENTITY down-regulate|advcl|down-regulating down-regulating|dobj|expression expression|nmod|END_ENTITY	These results suggest that CTGF is a regulator factor in the expression of MMPs , and 10H2DA down-regulate the concentration of MMPs probably by down-regulating the expression of CTGF .
21850473	8	10H2DA	1261,1267	CTGF	1162,1166	10H2DA	CTGF	null	1490	Chemical	Gene	treatment|nummod|START_ENTITY down-regulated|nmod|treatment down-regulated|nsubjpass|END_ENTITY	CTGF , a member of the C-terminal cystein-rich proteins -LRB- CCN -RRB- family , was down-regulated after 24-h 10H2DA treatment .
21948282	7	10H2DA	962,968	G-CSF	902,907	10H2DA	G-CSF	null	12985(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|appos|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
23754629	5	10H2DA	680,686	glucose_transporter_4	814,835	10H2DA	glucose transporter 4	null	20528(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|conj|increased increased|nmod|myotubes myotubes|nmod|translocation translocation|nmod|Glut4 Glut4|amod|END_ENTITY	10H2DA activates AMPK independently of insulin and significantly increased glucose uptake into L6 myotubes following translocation of glucose_transporter_4 -LRB- Glut4 -RRB- to the plasma membrane -LRB- PM -RRB- .
23754629	5	10H2DA	680,686	Glut4	837,842	10H2DA	Glut4	null	20528(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|conj|increased increased|nmod|myotubes myotubes|nmod|translocation translocation|nmod|END_ENTITY	10H2DA activates AMPK independently of insulin and significantly increased glucose uptake into L6 myotubes following translocation of glucose_transporter_4 -LRB- Glut4 -RRB- to the plasma membrane -LRB- PM -RRB- .
23754629	7	10H2DA	1073,1079	Glut4	1133,1138	10H2DA	Glut4	null	20528(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY stimulated|nsubj|administration stimulated|dobj|phosphorylation phosphorylation|conj|translocation translocation|amod|END_ENTITY	Oral administration of 10H2DA significantly stimulated phosphorylation of AMPK and Glut4 translocation to the PM in mouse skeletal muscle .
28740028	8	10H2DA	925,931	GLUT4	1075,1080	10H2DA	GLUT4	null	20528(Tax:10090)	Chemical	Gene	increased|nsubj|START_ENTITY increased|parataxis|correlate correlate|nmod|translocation translocation|compound|END_ENTITY	10H2DA increased the expression of phosphorylated AMPK -LRB- pAMPK -RRB- protein in skeletal muscles ; however , this expression did not correlate with increased GLUT4 translocation .
21948282	7	10H2DA	962,968	granulocyte_colony-stimulating_factor	863,900	10H2DA	granulocyte colony-stimulating factor	null	12985(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|conj|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
28740028	9	10H2DA	1109,1115	GSK-3b	1230,1236	10H2DA	GSK-3b	null	56637(Tax:10090)	Chemical	Gene	enhanced|nsubj|START_ENTITY enhanced|conj|activated activated|xcomp|signaling signaling|dobj|cascade cascade|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Furthermore , 10H2DA neither enhanced the expression of adiponectin receptor mRNA nor activated the insulin signaling cascade , such as GSK-3b phosphorylation , in the liver .
21948282	4	10H2DA	660,666	IFN-b	625,630	10H2DA	IFN-b	null	15977(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|acl|induced induced|nmod|over-expression over-expression|nmod|MyD88 MyD88|conj|END_ENTITY	In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA .
21948282	7	10H2DA	962,968	IFN-b	1035,1040	10H2DA	IFN-b	null	15977(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	5	10H2DA	747,753	IkB	712,715	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Degradation Degradation|conj|phosphorylation phosphorylation|nmod|kinase-a kinase-a|compound|END_ENTITY	Degradation of IkB-a and phosphorylation of IkB kinase-a were not inhibited by 10H2DA .
21948282	7	10H2DA	962,968	IkB	932,935	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|lipocalin-2 lipocalin-2|acl:relcl|dependent dependent|nmod|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	7	10H2DA	962,968	IkB	986,989	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	8	10H2DA	1157,1163	IkB	1199,1202	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	specifically|nmod:npmod|START_ENTITY inhibited|advmod|specifically inhibited|nsubj|END_ENTITY	Together , 10H2DA specifically inhibited LPS-induced IkB - expression , followed by inhibition of IkB - - dependent gene production .
21948282	8	10H2DA	1157,1163	IkB	1244,1247	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	specifically|nmod:npmod|START_ENTITY inhibited|advmod|specifically inhibited|nsubj|IkB IkB|dep|expression expression|acl|followed followed|nmod|inhibition inhibition|nmod|END_ENTITY	Together , 10H2DA specifically inhibited LPS-induced IkB - expression , followed by inhibition of IkB - - dependent gene production .
21948282	9	10H2DA	1305,1311	IkB	1485,1488	10H2DA	IkB	null	18036(Tax:10090)	Chemical	Gene	one|nsubj|START_ENTITY suggest|ccomp|one suggest|conj|candidate candidate|nmod|inflammatory inflammatory|acl|associated associated|nmod|production production|amod|END_ENTITY	These results suggest that 10H2DA is one of the components of royal jelly to show anti-inflammatory effects and could be a therapeutic drug candidate for inflammatory and autoimmune_diseases associated with IkB - and IL-6 production .
21948282	2	10H2DA	317,323	IL-6	346,350	10H2DA	IL-6	null	16193(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|dose-dependently dose-dependently|compound|END_ENTITY	10H2DA inhibited LPS-induced IL-6 production dose-dependently , but did not inhibit TNF-a production .
21948282	9	10H2DA	1305,1311	IL-6	1496,1500	10H2DA	IL-6	null	16193(Tax:10090)	Chemical	Gene	one|nsubj|START_ENTITY suggest|ccomp|one suggest|conj|candidate candidate|nmod|inflammatory inflammatory|acl|associated associated|nmod|production production|amod|IkB IkB|conj|END_ENTITY	These results suggest that 10H2DA is one of the components of royal jelly to show anti-inflammatory effects and could be a therapeutic drug candidate for inflammatory and autoimmune_diseases associated with IkB - and IL-6 production .
23079939	4	10H2DA	614,620	inducible_NO_synthase	548,569	10H2DA	inducible NO synthase	null	551143(Tax:7460)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|conj|END_ENTITY	LPS-induced NO production and inducible_NO_synthase -LRB- iNOS -RRB- gene transcription were inhibited by 10H2DA .
23079939	4	10H2DA	614,620	iNOS	571,575	10H2DA	iNOS	null	551143(Tax:7460)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|dep|END_ENTITY	LPS-induced NO production and inducible_NO_synthase -LRB- iNOS -RRB- gene transcription were inhibited by 10H2DA .
23079939	5	10H2DA	808,814	iNOS	773,777	10H2DA	iNOS	null	551143(Tax:7460)	Chemical	Gene	unaffected|nmod|START_ENTITY unaffected|nsubj|production production|acl:relcl|required required|nmod|induction induction|amod|END_ENTITY	LPS-stimulated interferon -LRB- IFN -RRB- - b production , IFN regulatory factor-1 induction and IFN-stimulated response element activation , which are required for iNOS induction , were unaffected by 10H2DA .
21948282	7	10H2DA	962,968	lipocalin-2	847,858	10H2DA	lipocalin-2	null	16819(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Production Production|nmod|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	7	10H2DA	962,968	MIP-2	1131,1136	10H2DA	MIP-2	null	20310(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|IFN-b IFN-b|appos|-1 -1|amod|a a|conj|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	7	10H2DA	962,968	monocyte_chemotactic_protein-1	1049,1079	10H2DA	monocyte chemotactic protein-1	null	20296(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|was was|nsubj|that that|nmod|IFN-b IFN-b|appos|-1 -1|amod|END_ENTITY	Production of lipocalin-2 and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- , which is dependent on IkB - , was also inhibited by 10H2DA , whereas that of IkB - - independent cytokines/chemokines , such as IFN-b , murine monocyte_chemotactic_protein-1 -LRB- JE -RRB- , macrophage_inflammatory_protein _ -LRB- MIP -RRB- -1 a and MIP-2 , was not .
21948282	4	10H2DA	660,666	MyD88	560,565	10H2DA	MyD88	null	17874(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|acl|induced induced|nmod|over-expression over-expression|nmod|END_ENTITY	In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA .
28740028	11	10H2DA	1525,1531	Pgc-1a	1618,1624	10H2DA	Pgc-1a	null	19017(Tax:10090)	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|nmod|part part|nmod|activation activation|nmod|expression expression|compound|END_ENTITY	These findings suggest that 10H2DA is involved in the improvement of type 2 diabetes , at least in part via activation of Pgc-1a expression , but does not prevent obesity .
21948282	2	10H2DA	317,323	TNF-a	400,405	10H2DA	TNF-a	null	21926(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|conj|inhibit inhibit|dobj|production production|amod|END_ENTITY	10H2DA inhibited LPS-induced IL-6 production dose-dependently , but did not inhibit TNF-a production .
21948282	4	10H2DA	660,666	TRIF	632,636	10H2DA	TRIF	null	106759(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|appos|END_ENTITY	In addition , NF-kB activation induced by over-expression of either MyD88 or Toll/IL -1 receptor domain-containing adaptor inducing IFN-b -LRB- TRIF -RRB- was also inhibited by 10H2DA .
27847405	4	10-H2DA	628,635	interleukin-10	770,784	10-H2DA	interleukin-10	null	3586	Chemical	Gene	had|nsubj|START_ENTITY had|dobj|effects effects|amod|nitric_oxide nitric_oxide|conj|END_ENTITY	The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production .
27847405	4	10-H2DA	628,635	TNF-a	809,814	10-H2DA	TNF-a	null	7124	Chemical	Gene	had|nsubj|START_ENTITY showed|ccomp|had showed|conj|decreased decreased|dobj|production production|amod|END_ENTITY	The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production .
24520713	0	10H2O	73,78	Cd2	11,14	10H2O	Cd2	null	914	Chemical	Gene	x|nummod|START_ENTITY FS|dep|x salt|dep|FS water|nmod|salt +|nmod|water +|compound|END_ENTITY	Removal of Cd2 + from water by Friedel 's salt -LRB- FS : 3CaO x A12O3 x CaCI2 x 10H2O -RRB- : sorption characteristics and mechanisms .
11969424	10	10-HCO-DHF	1484,1494	cytochrome_c	1444,1456	10-HCO-DHF	cytochrome c	null	54205	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|amod|END_ENTITY	To our knowledge , this cytochrome_c oxidation of 10-HCO-THF to 10-HCO-DHF in the mitochondrial intermembrane space represents a possible folate metabolic pathway previously unidentified and would explain the bioactivity of unnatural carbon-6 isomers , -LRB- 6R -RRB- -5 - HCO-THF_and _ -LRB- 6S -RRB- -5,10 - CH-THF , in humans .
11969424	8	10-HCO-DHF	1200,1210	cytochrome_c	1163,1175	10-HCO-DHF	cytochrome c	null	54205	Chemical	Gene	identified|parataxis|START_ENTITY identified|nmod|IV IV|acl:relcl|contains contains|xcomp|END_ENTITY	The site of electron donation was identified as complex IV , which contains cytochrome_c ; the folate product was 10-HCO-DHF , and the reaction was saturable with respect to 10-HCO-THF .
8948466	7	10-HCO-H2folate	398,413	C-6	558,561	10-HCO-H2folate	C-6	null	729	Chemical	Gene	spectroscopy|nmod|START_ENTITY suggested|nsubj|spectroscopy suggested|conj|proposed proposed|nsubj|evidence evidence|nmod|proton proton|compound|END_ENTITY	1H-NMR spectroscopy of 10-HCO-H2folate -LRB- in 2H2O ; 300 MHz -RRB- suggested a pure compound and gave resonances for one formyl group proton , two protons on C-7_and_C-9 , and no evidence for a C-6 proton , which is consistent with the structure proposed .
8948466	7	10-HCO-H2folate	398,413	C-7_and_C-9	523,534	10-HCO-H2folate	C-7 and C-9	null	730;735	Chemical	Gene	spectroscopy|nmod|START_ENTITY suggested|nsubj|spectroscopy suggested|conj|gave gave|dobj|protons protons|nmod|END_ENTITY	1H-NMR spectroscopy of 10-HCO-H2folate -LRB- in 2H2O ; 300 MHz -RRB- suggested a pure compound and gave resonances for one formyl group proton , two protons on C-7_and_C-9 , and no evidence for a C-6 proton , which is consistent with the structure proposed .
7646059	1	10-HCO-H4PteGlu	220,235	10-Formyltetrahydrofolate_dehydrogenase	83,122	10-HCO-H4PteGlu	10-Formyltetrahydrofolate dehydrogenase	null	64392(Tax:10116)	Chemical	Gene	10-formyltetrahydrofolate|dep|START_ENTITY oxidation|nmod|10-formyltetrahydrofolate NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate .
7646059	1	10-HCO-H4PteGlu	327,342	10-Formyltetrahydrofolate_dehydrogenase	83,122	10-HCO-H4PteGlu	10-Formyltetrahydrofolate dehydrogenase	null	64392(Tax:10116)	Chemical	Gene	cleavage|nmod|START_ENTITY NADP|dep|cleavage H4PteGlu|conj|NADP tetrahydrofolate|dobj|H4PteGlu 10-formyltetrahydrofolate|acl|tetrahydrofolate oxidation|nmod|10-formyltetrahydrofolate NADP|dep|oxidation catalyzes|dobj|NADP catalyzes|nsubj|END_ENTITY	10-Formyltetrahydrofolate_dehydrogenase -LRB- 10-FTH-FDH : EC 1.5.1.6 -RRB- catalyzes the NADP -LRB- + -RRB- - dependent oxidation of 10-formyltetrahydrofolate -LRB- 10-HCO-H4PteGlu -RRB- to tetrahydrofolate -LRB- H4PteGlu -RRB- and CO2 and the NADP -LRB- + -RRB- - independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate .
7646059	10	10-HCO-H4PteGlu	1643,1658	10-FTHFDH	1536,1545	10-HCO-H4PteGlu	10-FTHFDH	null	64392(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY shows|dobj|site shows|nsubj|domain domain|nmod|END_ENTITY	The N-terminal domain of 10-FTHFDH shows identity to glycinamide_ribonucleotide transformylase -LRB- EC 2.1.2.2 -RRB- and contains a putative 10-HCO-H4PteGlu binding site but shows no GAR-TF activity .
7646059	11	10-HCO-H4PteGlu	1733,1748	10-FTHFDH	1752,1761	10-HCO-H4PteGlu	10-FTHFDH	null	64392(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	NADP -LRB- + -RRB- - dependent oxidation of 10-HCO-H4PteGlu by 10-FTHFDH was inhibited by the folate anti-metabolite , 5,10-dideazatetrahydrofolate , a known GAR-TF inhibitor .
11969424	10	10-HCO-THF	1470,1480	cytochrome_c	1444,1456	10-HCO-THF	cytochrome c	null	54205	Chemical	Gene	10-HCO-DHF|nummod|START_ENTITY oxidation|nmod|10-HCO-DHF oxidation|amod|END_ENTITY	To our knowledge , this cytochrome_c oxidation of 10-HCO-THF to 10-HCO-DHF in the mitochondrial intermembrane space represents a possible folate metabolic pathway previously unidentified and would explain the bioactivity of unnatural carbon-6 isomers , -LRB- 6R -RRB- -5 - HCO-THF_and _ -LRB- 6S -RRB- -5,10 - CH-THF , in humans .
11969424	8	10-HCO-THF	1259,1269	cytochrome_c	1163,1175	10-HCO-THF	cytochrome c	null	54205	Chemical	Gene	saturable|nmod|START_ENTITY 10-HCO-DHF|conj|saturable identified|parataxis|10-HCO-DHF identified|nmod|IV IV|acl:relcl|contains contains|xcomp|END_ENTITY	The site of electron donation was identified as complex IV , which contains cytochrome_c ; the folate product was 10-HCO-DHF , and the reaction was saturable with respect to 10-HCO-THF .
26815184	1	10-HCPT	167,174	vascular_endothelial_growth_factor	197,231	10-HCPT	vascular endothelial growth factor	null	7422	Chemical	Gene	10-Hydroxycamptotbecine|appos|START_ENTITY effect|nmod|10-Hydroxycamptotbecine study|dobj|effect study|nmod|expression expression|nmod|END_ENTITY	OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- .
26815184	1	10-HCPT	167,174	VEGF	232,236	10-HCPT	VEGF	null	7422	Chemical	Gene	10-Hydroxycamptotbecine|appos|START_ENTITY effect|nmod|10-Hydroxycamptotbecine study|dobj|effect study|nmod|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- .
26815184	4	10-HCPT	809,816	VEGF	896,900	10-HCPT	VEGF	null	7422	Chemical	Gene	groups|nummod|START_ENTITY dose|nmod:npmod|groups showed|advmod|dose showed|nmod|effect effect|acl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY	RESULTS : Compared with control group , high and low dose 10-HCPT groups showed significant values on the effect of inhibiting the expression of VEGF in RASFs .
26815184	6	10-HCPT	1158,1165	VEGF	1224,1228	10-HCPT	VEGF	null	7422	Chemical	Gene	showed|nsubj|START_ENTITY showed|advcl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY	CONCLUSION : Compared with MTX , 10-HCPT showed significant effect on inhibiting the expression of VEGF in RASFs .
27049436	4	10HDA	777,782	EC-SOD	922,928	10HDA	EC-SOD	null	6649	Chemical	Gene	10-hydroxydecanoic_acid|dep|START_ENTITY constituents|amod|10-hydroxydecanoic_acid effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|END_ENTITY	Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells .
23995057	5	10HDA	794,799	IL-6	872,876	10HDA	IL-6	null	16193(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|conj|necrosis necrosis|dobj|production production|compound|factor-a factor-a|conj|END_ENTITY	10HDA inhibited LPS-induced NO production , but not tumor necrosis factor-a or IL-6 production .
23995057	11	10HDA	1444,1449	IRF-1	1505,1510	10HDA	IRF-1	null	16362(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|advcl|inhibiting inhibiting|dobj|translation translation|compound|END_ENTITY	These results suggest that 10HDA inhibited LPS-induced NO production through inhibiting IRF-1 translation .
23995057	8	10HDA	1203,1208	IRF-1	1162,1167	10HDA	IRF-1	null	16362(Tax:10090)	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|increase increase|nmod|mRNA mRNA|compound|END_ENTITY	The LPS-induced increase of IRF-1 mRNA , however , was not affected by 10HDA .
23995057	9	10HDA	1298,1303	IRF-1	1224,1229	10HDA	IRF-1	null	16362(Tax:10090)	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|level level|compound|END_ENTITY	We found that IRF-1 mRNA level in the polysomal fraction was significantly decreased by 10HDA .
23995057	7	10HDA	1127,1132	STAT1	1019,1024	10HDA	STAT1	null	20846(Tax:10090)	Chemical	Gene	reduced|nmod|START_ENTITY -1|ccomp|reduced affected|conj|-1 affected|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of STAT1 and STAT2 was not affected , but IFN-regulatory_factor _ -LRB- IRF -RRB- -1 production was significantly reduced by 10HDA .
23995057	7	10HDA	1127,1132	STAT2	1029,1034	10HDA	STAT2	null	20847(Tax:10090)	Chemical	Gene	reduced|nmod|START_ENTITY -1|ccomp|reduced affected|conj|-1 affected|nsubjpass|Phosphorylation Phosphorylation|nmod|STAT1 STAT1|conj|END_ENTITY	Phosphorylation of STAT1 and STAT2 was not affected , but IFN-regulatory_factor _ -LRB- IRF -RRB- -1 production was significantly reduced by 10HDA .
27049436	4	10HDA	777,782	THP-1	932,937	10HDA	THP-1	null	2736	Chemical	Gene	10-hydroxydecanoic_acid|dep|START_ENTITY constituents|amod|10-hydroxydecanoic_acid effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|EC-SOD EC-SOD|nmod|cells cells|compound|END_ENTITY	Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells .
25789174	7	10-HDA	1140,1146	daf-15	1204,1210	10-HDA	daf-15	null	177770(Tax:6239)	Chemical	Gene	extend|nsubj|START_ENTITY extend|nmod|END_ENTITY	We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15 , which encodes Raptor , a target of rapamycin -LRB- TOR -RRB- components , indicating that 10-HDA shared some longevity control mechanisms with TOR signaling .
25789174	7	10-HDA	1290,1296	daf-15	1204,1210	10-HDA	daf-15	null	177770(Tax:6239)	Chemical	Gene	shared|nsubj|START_ENTITY indicating|ccomp|shared encodes|dep|indicating END_ENTITY|acl:relcl|encodes	We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15 , which encodes Raptor , a target of rapamycin -LRB- TOR -RRB- components , indicating that 10-HDA shared some longevity control mechanisms with TOR signaling .
21858156	12	10-HDA	1620,1626	DAF-16	1719,1725	10-HDA	DAF-16	null	172981(Tax:6239)	Chemical	Gene	10-Hydroxy-2-decenoic_acid|appos|START_ENTITY increased|nsubj|10-Hydroxy-2-decenoic_acid increased|nmod|activity activity|compound|END_ENTITY	10-Hydroxy-2-decenoic_acid -LRB- 10-HDA -RRB- , which was present at high concentrations in pRJ-Fr .5 , increased lifespan independently of DAF-16 activity .
25789174	4	10-HDA	669,675	daf-2	713,718	10-HDA	daf-2	null	175410(Tax:6239)	Chemical	Gene	extended|nsubj|START_ENTITY extended|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY	10-HDA further extended the lifespan of the daf-2 mutants , which exhibit long lifespan through reducing insulin-like_signaling -LRB- ILS -RRB- , indicating that 10-HDA extended lifespan independently of ILS .
25789174	4	10-HDA	819,825	daf-2	713,718	10-HDA	daf-2	null	175410(Tax:6239)	Chemical	Gene	lifespan|amod|START_ENTITY indicating|dobj|lifespan extended|advcl|indicating extended|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY	10-HDA further extended the lifespan of the daf-2 mutants , which exhibit long lifespan through reducing insulin-like_signaling -LRB- ILS -RRB- , indicating that 10-HDA extended lifespan independently of ILS .
25789174	5	10-HDA	885,891	eat-2	927,932	10-HDA	eat-2	null	175072(Tax:6239)	Chemical	Gene	extend|nsubj|START_ENTITY extend|dobj|lifespan lifespan|nmod|mutants mutants|amod|END_ENTITY	On the other hand , 10-HDA did not extend the lifespan of the eat-2 mutants , which show long lifespan through dietary restriction caused by a food-intake defect .
28417225	6	10-HDA	1270,1276	electron_transfer_flavoprotein_subunit_beta	1154,1197	10-HDA	electron transfer flavoprotein subunit beta	null	410308(Tax:7460)	Chemical	Gene	production|nummod|START_ENTITY decreased|dobj|production decreased|nsubj|knockdown knockdown|nmod|END_ENTITY	And RNA interference -LRB- RNAi -RRB- results demonstrated that knockdown of electron_transfer_flavoprotein_subunit_beta -LRB- ETF-b -RRB- , one of the protein related to fatty_acid metabolism , decreased 10-HDA production of worker bees , suggesting that ETF-b was necessary for 10-HDA biosynthesis .
28417225	6	10-HDA	1344,1350	electron_transfer_flavoprotein_subunit_beta	1154,1197	10-HDA	electron transfer flavoprotein subunit beta	null	410308(Tax:7460)	Chemical	Gene	biosynthesis|nummod|START_ENTITY necessary|nmod|biosynthesis suggesting|ccomp|necessary decreased|advcl|suggesting decreased|nsubj|knockdown knockdown|nmod|END_ENTITY	And RNA interference -LRB- RNAi -RRB- results demonstrated that knockdown of electron_transfer_flavoprotein_subunit_beta -LRB- ETF-b -RRB- , one of the protein related to fatty_acid metabolism , decreased 10-HDA production of worker bees , suggesting that ETF-b was necessary for 10-HDA biosynthesis .
17630200	5	10-HDA	625,631	IL-2	694,698	10-HDA	IL-2	MESH:C017552	116562(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|nmod|production production|appos|END_ENTITY	The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression .
17630200	5	10-HDA	625,631	IL-2	734,738	10-HDA	IL-2	MESH:C017552	116562(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|conj|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression .
17630200	5	10-HDA	625,631	interleukin-2	679,692	10-HDA	interleukin-2	MESH:C017552	116562(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY stronger|nsubj|effect stronger|conj|followed followed|nmod|decrease decrease|nmod|production production|compound|END_ENTITY	The effect of 10-HDA was stronger and was followed by a decrease in interleukin-2 -LRB- IL-2 -RRB- production and down-regulation of IL-2 receptor expression .
28793915	6	10-HDA	1012,1018	microphthalmia-associated_transcription_factor	1127,1173	10-HDA	microphthalmia-associated transcription factor	null	17342(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|conj|END_ENTITY	Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells .
28793915	5	10-HDA	890,896	MITF	911,915	10-HDA	MITF	null	17342(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|compound|END_ENTITY	RESULTS : The results showed that 10-HDA inhibited the MITF protein expression -LRB- IC50 0.86 mM -RRB- in B16F1 melanoma cells .
28793915	6	10-HDA	1012,1018	MITF	1175,1179	10-HDA	MITF	null	17342(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|appos|END_ENTITY	Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells .
21812645	8	10-HDA	1117,1123	MMP-1	1198,1203	10-HDA	MMP-1	null	4312	Chemical	Gene	RJ|conj|START_ENTITY treated|nmod|RJ fibroblasts|acl|treated increased|nsubj|fibroblasts increased|conj|changed changed|nsubjpass|level level|nmod|END_ENTITY	The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-b1 productions , but the level of MMP-1 was not changed .
23030720	11	10-HDA	1436,1442	MMP-1	1484,1489	10-HDA	MMP-1	null	4312	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|END_ENTITY	Moreover , 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels .
23030720	13	10-HDA	1710,1716	MMP-1	1762,1767	10-HDA	MMP-1	null	4312	Chemical	Gene	prevent|nsubj|START_ENTITY provide|ccomp|prevent provide|conj|inhibit inhibit|dobj|expressions expressions|amod|END_ENTITY	CONCLUSION : The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions .
23030720	11	10-HDA	1436,1442	MMP-3	1494,1499	10-HDA	MMP-3	null	4314	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|MMP-1 MMP-1|conj|END_ENTITY	Moreover , 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels .
23030720	13	10-HDA	1710,1716	MMP-3	1772,1777	10-HDA	MMP-3	null	4314	Chemical	Gene	prevent|nsubj|START_ENTITY provide|ccomp|prevent provide|conj|inhibit inhibit|dobj|expressions expressions|amod|MMP-1 MMP-1|conj|END_ENTITY	CONCLUSION : The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions .
23030720	12	10-HDA	1563,1569	p38	1625,1628	10-HDA	p38	null	1432	Chemical	Gene	Treatment|nmod|START_ENTITY reduced|nsubj|Treatment reduced|dobj|activation activation|nmod|JNK JNK|conj|pathways pathways|amod|END_ENTITY	Treatment with 10-HDA also reduced the UVA-induced activation of the JNK and p38 MAPK pathways .
21812645	8	10-HDA	1117,1123	TGF-b1	1161,1167	10-HDA	TGF-b1	null	7040	Chemical	Gene	RJ|conj|START_ENTITY treated|nmod|RJ fibroblasts|acl|treated increased|nsubj|fibroblasts increased|dobj|I I|conj|productions productions|compound|END_ENTITY	The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-b1 productions , but the level of MMP-1 was not changed .
28793915	6	10-HDA	1012,1018	TRP-1	1108,1113	10-HDA	TRP-1	null	22178(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|END_ENTITY	Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells .
28793915	6	10-HDA	1012,1018	TRP-2	1116,1121	10-HDA	TRP-2	null	104042(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|conj|END_ENTITY	Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells .
28793915	6	10-HDA	1012,1018	tyrosinase-related_protein_1	1078,1106	10-HDA	tyrosinase-related protein 1	null	22178(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|conj|expression expression|nmod|TRP-1 TRP-1|amod|END_ENTITY	Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related_protein_1 -LRB- TRP-1 -RRB- , TRP-2 , and microphthalmia-associated_transcription_factor -LRB- MITF -RRB- in B16F1 melanoma cells .
27847405	4	10-HDAA	637,644	interleukin-10	770,784	10-HDAA	interleukin-10	null	3586	Chemical	Gene	10-H2DA|conj|START_ENTITY had|nsubj|10-H2DA had|dobj|effects effects|amod|nitric_oxide nitric_oxide|conj|END_ENTITY	The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production .
27847405	4	10-HDAA	637,644	TNF-a	809,814	10-HDAA	TNF-a	null	7124	Chemical	Gene	10-H2DA|conj|START_ENTITY had|nsubj|10-H2DA showed|ccomp|had showed|conj|decreased decreased|dobj|production production|amod|END_ENTITY	The results showed that 10-H2DA , 10-HDAA , and SEA had potent , dose-dependent inhibitory effects on the release of the major inflammatory-mediators , nitric_oxide , and interleukin-10 , and only SEA decreased TNF-a production .
9435160	3	10-HETE	663,670	CYP1A2	412,418	10-HETE	CYP1A2	MESH:C095133	1544	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
9435160	3	10-HETE	663,670	CYP1A2	589,595	10-HETE	CYP1A2	MESH:C095133	1544	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nmod|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
9435160	3	10-HETE	663,670	CYP2C19	436,443	10-HETE	CYP2C19	MESH:C095133	1557	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
9435160	3	10-HETE	663,670	CYP2C8	420,426	10-HETE	CYP2C8	MESH:C095133	1558	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
9435160	3	10-HETE	663,670	CYP2C9	428,434	10-HETE	CYP2C9	MESH:C095133	1559	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
9435160	3	10-HETE	663,670	CYP3A4	448,454	10-HETE	CYP3A4	MESH:C095133	1576	Chemical	Gene	13-hydroxyeicosatrienoic_acid|amod|START_ENTITY oxygenated|nmod|13-hydroxyeicosatrienoic_acid oxygenated|nsubjpass|CYP1A2 CYP1A2|conj|END_ENTITY	CYP1A2 , CYP2C8 , CYP2C9 , CYP2C19 and CYP3A4 converted -LSB- 14C -RSB- linoleic_acid to 14C-labeled_11-hydroxyoctadecadienoic_acid -LRB- 11-HODE -RRB- , whereas -LSB- 14C -RSB- arachidonic_acid was oxygenated by CYP1A2 and CYP3A4 to 14C-labeled 13-hydroxyeicosatrienoic_acid -LRB- 13-HETE -RRB- , 10-HETE and 7-HETE as determined by HPLC .
15301793	4	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	700,750	PAF	762,765	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	PAF	null	300795(Tax:10116)	Chemical	Gene	START_ENTITY|dep|END_ENTITY	We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha .
15301793	4	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	700,750	PAF	816,819	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	PAF	null	300795(Tax:10116)	Chemical	Gene	A23187|amod|START_ENTITY A23187|nmod|END_ENTITY	We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha .
15301793	4	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	700,750	TNF-alpha	824,833	1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	A23187|amod|START_ENTITY A23187|nmod|PAF PAF|conj|END_ENTITY	We also examined the response to A23187 -LRB- calcium ionophore -RRB- , 1-0-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine -LRB- synthetic PAF -RRB- and dexamethasone on meconium-induced release of PAF and TNF-alpha .
3775692	1	1-0-hexadecyl_Paf-acether	218,243	thrombin	138,146	1-0-hexadecyl Paf-acether	thrombin	null	100009146(Tax:9986)	Chemical	Gene	Collagen|amod|START_ENTITY Collagen|appos|END_ENTITY	Collagen -LRB- 10-40 micrograms kg-1 -RRB- , thrombin -LRB- 1-10 units kg-1 -RRB- , adenosine_diphosphate -LRB- ADP ; 3-300 micrograms kg-1 -RRB- , 1-0-hexadecyl_Paf-acether and 1-0-octadecyl_Paf-acether -LRB- 1-300 ng kg-1 -RRB- administered by bolus intravenous injection each caused dose-dependent thrombocytopoenia accompanied by marked hypotension in anaesthetized rabbits .
16175144	8	10-hydroxy	1078,1088	CYP2D6	1112,1118	10-hydroxy	CYP2D6	null	1565	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Nortriptyline is further metabolized to 10-hydroxy metabolites , mainly by CYP2D6 .
8867869	0	10-hydroxy	52,62	CYP2D6	95,101	10-hydroxy	CYP2D6	null	1565	Chemical	Gene	metabolite|amod|START_ENTITY nortriptyline|conj|metabolite levels|nmod|nortriptyline levels|dep|relationship relationship|nmod|genotype genotype|compound|END_ENTITY	Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite : relationship to the CYP2D6 genotype .
9797795	0	10-hydroxy	42,52	CYP2D6	97,103	10-hydroxy	CYP2D6	null	1565	Chemical	Gene	metabolite|amod|START_ENTITY nortriptyline|conj|metabolite Pharmacokinetics|nmod|nortriptyline Pharmacokinetics|nmod|genotypes genotypes|compound|END_ENTITY	Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes .
6850066	2	10-hydroxy	456,466	ml-1_and_300_pg_ml-1	427,447	10-hydroxy	ml-1 and 300 pg ml-1	null	112744	Chemical	Gene	metabolite|amod|START_ENTITY END_ENTITY|nmod|metabolite	The minimum detectable concentrations for ketotifen and its demethylated metabolites were 50 pg ml-1_and_300_pg_ml-1 for the 10-hydroxy metabolite .
11052802	5	10-hydroxy	808,818	serum_albumin	887,900	10-hydroxy	serum albumin	null	213	Chemical	Gene	7-alkylsilyl|conj|START_ENTITY substitution|amod|7-alkylsilyl enhances|nsubj|substitution enhances|nmod|presence presence|nmod|END_ENTITY	In addition , the dual 7-alkylsilyl and 10-hydroxy substitution in 14 enhances drug stability in the presence of human serum_albumin .
21850473	0	10-hydroxy-2-decenoic_acid	58,84	Connective_tissue_growth_factor	0,31	10-hydroxy-2-decenoic acid	Connective tissue growth factor	MESH:C055543	1490	Chemical	Gene	MMPs|amod|START_ENTITY related|nmod|MMPs regulator|acl|related END_ENTITY|appos|regulator	Connective_tissue_growth_factor , a regulator related with 10-hydroxy-2-decenoic_acid down-regulate MMPs in rheumatoid_arthritis .
27664731	3	10-hydroxy-2-decenoic_acid	629,655	Royalisin	618,627	10-hydroxy-2-decenoic acid	Royalisin	MESH:C055543	406143(Tax:7460)	Chemical	Gene	Proteins|appos|START_ENTITY Proteins|appos|END_ENTITY	Antimicrobial activities of crude Royal Jelly , Royalisin , 10-hydroxy-2-decenoic_acid , Jelleines , Major Royal Jelly Proteins against different bacteria have been reported .
21858156	12	10-Hydroxy-2-decenoic_acid	1592,1618	DAF-16	1719,1725	10-Hydroxy-2-decenoic acid	DAF-16	MESH:C055543	172981(Tax:6239)	Chemical	Gene	increased|nsubj|START_ENTITY increased|nmod|activity activity|compound|END_ENTITY	10-Hydroxy-2-decenoic_acid -LRB- 10-HDA -RRB- , which was present at high concentrations in pRJ-Fr .5 , increased lifespan independently of DAF-16 activity .
14696921	3	10-hydroxyaconitine	657,676	MSn	522,525	10-hydroxyaconitine	MSn	CHEBI:2429	4478	Chemical	Gene	mesaconitine|conj|START_ENTITY acid_esters|acl|mesaconitine elucidated|xcomp|acid_esters elucidated|advcl|spectra spectra|compound|END_ENTITY	Based on their MSn spectra , the structures of the five novel compounds were elucidated to be C3,C8-difatty _ acid_esters of mesaconitine , aconitine and 10-hydroxyaconitine .
26815184	0	10-hydroxycamptotbecine	11,34	VEGF	56,60	10-hydroxycamptotbecine	VEGF	null	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of 10-hydroxycamptotbecine on the expression of VEGF in rheumatoid_arthritis synovial fibroblasts -RSB- .
26815184	1	10-Hydroxycamptotbecine	142,165	vascular_endothelial_growth_factor	197,231	10-Hydroxycamptotbecine	vascular endothelial growth factor	null	7422	Chemical	Gene	effect|nmod|START_ENTITY study|dobj|effect study|nmod|expression expression|nmod|END_ENTITY	OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- .
26815184	1	10-Hydroxycamptotbecine	142,165	VEGF	232,236	10-Hydroxycamptotbecine	VEGF	null	7422	Chemical	Gene	effect|nmod|START_ENTITY study|dobj|effect study|nmod|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	OBJECTIVE : To study the effect of 10-Hydroxycamptotbecine -LRB- 10-HCPT -RRB- on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts -LRB- RASFs -RRB- .
27721159	0	10-hydroxycamptothecin	63,85	Akt	130,133	10-hydroxycamptothecin	Akt	MESH:C028098	207	Chemical	Gene	I|conj|START_ENTITY effect|nmod|I effect|acl|p38 p38|dobj|MAPK MAPK|conj|END_ENTITY	Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways .
16084097	1	10-hydroxycamptothecin	157,179	cis-4	107,112	10-hydroxycamptothecin	cis-4	MESH:C028098	54607(Tax:10090)	Chemical	Gene	docosahexenoic_acid|conj|START_ENTITY END_ENTITY|dep|docosahexenoic_acid	We have synthesized a conjugate of cis-4 ,7,10,13,16,19 - docosahexenoic_acid -LRB- DHA -RRB- and 10-hydroxycamptothecin -LRB- HCPT -RRB- , DHA-HCPT .
11052802	7	10-hydroxycamptothecin	1205,1227	CPT-11	1294,1300	10-hydroxycamptothecin	CPT-11	MESH:C028098	963084(Tax:115711)	Chemical	Gene	comparable|conj|START_ENTITY analogues|amod|comparable topotecan|nmod|analogues topotecan|conj|END_ENTITY	In vitro cytotoxicity assays using multiple different cell lines derived from eight distinct tumor types indicate that 14 is of comparable potency to camptothecin and 10-hydroxycamptothecin , as well as the FDA-approved camptothecin analogues topotecan and CPT-11 .
8010056	0	10-hydroxycamptothecin	62,84	DNA_topoisomerase_I	86,105	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin , DNA_topoisomerase_I inhibitor , in murine ascites_hepatoma cells .
8239542	0	10-hydroxycamptothecin	41,63	DNA_topoisomerase_I	10,29	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of DNA_topoisomerase_I inhibitor , 10-hydroxycamptothecin , on the structure and function of nuclei and nuclear matrix in bladder_carcinoma MBT-2 cells .
8239542	1	10-hydroxycamptothecin	173,195	DNA_topoisomerase_I	206,225	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	The effects of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a DNA_topoisomerase_I inhibitor , on the structure of nuclei and nuclear matrix and new DNA replication was investigated in murine bladder_carcinoma MBT-2 cells .
27721159	0	10-hydroxycamptothecin	63,85	ERK	121,124	10-hydroxycamptothecin	ERK	MESH:C028098	5594	Chemical	Gene	I|conj|START_ENTITY effect|nmod|I effect|acl|p38 p38|dobj|MAPK MAPK|conj|END_ENTITY	Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways .
20810290	1	10-hydroxycamptothecin	256,278	HIF-1a	318,324	10-hydroxycamptothecin	HIF-1a	MESH:C028098	100009579(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|hypoxia-inducible_factor-1a hypoxia-inducible_factor-1a|dep|END_ENTITY	PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model .
20810290	1	10-hydroxycamptothecin	256,278	HIF-1a	340,346	10-hydroxycamptothecin	HIF-1a	MESH:C028098	100009579(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY effect|nmod|administration evaluate|dobj|effect evaluate|nmod|expression expression|compound|END_ENTITY	PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model .
20810290	0	10-hydroxycamptothecin	48,70	hypoxia-inducible_factor-1a	74,101	10-hydroxycamptothecin	hypoxia-inducible factor-1a	MESH:C028098	100009579(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Experimental evaluation of inhibitory effect of 10-hydroxycamptothecin on hypoxia-inducible_factor-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization .
20810290	1	10-hydroxycamptothecin	256,278	hypoxia-inducible_factor-1a	289,316	10-hydroxycamptothecin	hypoxia-inducible factor-1a	MESH:C028098	100009579(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	PURPOSE : To evaluate the effect of transcatheter administration of 10-hydroxycamptothecin -LRB- HCPT -RRB- , a hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- inhibitor , on HIF-1a expression and angiogenesis in liver_tumors after transcatheter arterial_embolization in an animal model .
22320884	6	10-hydroxycamptothecin	1144,1166	MARVELD1	1058,1066	10-hydroxycamptothecin	MARVELD1	MESH:C028098	83742	Chemical	Gene	epirubicin|conj|START_ENTITY enhance|nmod|epirubicin enhance|nsubj|overexpression overexpression|compound|END_ENTITY	MARVELD1 overexpression could enhance chemosensitivity of HCC cells to epirubicin and 10-hydroxycamptothecin .
10493945	12	10-hydroxycamptothecin	1892,1914	MDM2	1837,1841	10-hydroxycamptothecin	MDM2	MESH:C028098	4193	Chemical	Gene	adriamycin|conj|START_ENTITY agents|amod|adriamycin observed|nsubj|agents observed|nmod|effects effects|nmod|inhibition inhibition|compound|END_ENTITY	Moreover , in vivo synergistically therapeutic effects of MDM2 inhibition and DNA damaging agents adriamycin and 10-hydroxycamptothecin were observed .
13130078	7	10-hydroxycamptothecin	1255,1277	MDM2	1133,1137	10-hydroxycamptothecin	MDM2	MESH:C028098	4193	Chemical	Gene	agents|amod|START_ENTITY effects|nmod|agents potentiated|dobj|effects apoptosis|conj|potentiated apoptosis|nsubj|proliferation proliferation|nummod|END_ENTITY	In all three cell lines , MDM2 inhibition reduced cell proliferation , induced apoptosis , and potentiated the effects of the chemotherapeutic agents 10-hydroxycamptothecin and paclitaxel .
22132187	6	10-hydroxycamptothecin	979,1001	MG132	1148,1153	10-hydroxycamptothecin	MG132	MESH:C028098	875581(Tax:243273)	Chemical	Gene	topoisomerases|appos|START_ENTITY microtubules|conj|topoisomerases microtubules|conj|RNA RNA|conj|synthesis synthesis|appos|gliotoxin gliotoxin|dep|mitomycin_C mitomycin_C|compound|END_ENTITY	Interestingly , these compounds were acting on distinct cellular targets , including microtubules -LRB- paclitaxel , podophyllotoxin , vinblastine -RRB- and topoisomerases -LRB- 10-hydroxycamptothecin , camptothecin , daunorubicin , doxorubicin , etoposide -RRB- as well as DNA , RNA and protein synthesis and turnover -LRB- anisomycin , aphidicholin , gliotoxin , MG132 , methotrexate , mitomycin_C -RRB- .
26744836	10	10-hydroxycamptothecin	1018,1040	OAT3	1154,1158	10-hydroxycamptothecin	OAT3	MESH:C028098	9376	Chemical	Gene	CPT|amod|START_ENTITY inhibit|nsubj|CPT inhibit|dobj|activity activity|nmod|END_ENTITY	Our data revealed that CPT , 10-hydroxycamptothecin -LRB- HCPT -RRB- , 10-methoxycamptothecin -LRB- MCPT -RRB- and 9-nitrocamptothecin -LRB- 9NC -RRB- significantly inhibit the uptake activity of OAT3 .
12518324	7	10-hydroxycamptothecin	1266,1288	p21	1225,1228	10-hydroxycamptothecin	p21	MESH:C028098	644914	Chemical	Gene	agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|conj|induction induction|amod|END_ENTITY	The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel .
14751837	6	10-hydroxycamptothecin	1184,1206	p21	1143,1146	10-hydroxycamptothecin	p21	MESH:C028098	644914	Chemical	Gene	agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|conj|induction induction|amod|END_ENTITY	The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel .
9499438	0	10-hydroxycamptothecin	149,171	p21WAF1/CIP1	16,28	10-hydroxycamptothecin	p21WAF1/CIP1	MESH:C028098	1026	Chemical	Gene	drugs|amod|START_ENTITY induced|nmod|drugs induced|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of p21WAF1/CIP1 in human breast_cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways .
27721159	0	10-hydroxycamptothecin	63,85	p38	111,114	10-hydroxycamptothecin	p38	MESH:C028098	1432	Chemical	Gene	I|conj|START_ENTITY effect|nmod|I effect|acl|END_ENTITY	Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung_cancer cells via p38 MAPK , ERK , and Akt signaling pathways .
12518324	7	10-hydroxycamptothecin	1266,1288	p53	1206,1209	10-hydroxycamptothecin	p53	MESH:C028098	7157	Chemical	Gene	agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|compound|END_ENTITY	The antisense oligonucleotide also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel .
14751837	6	10-hydroxycamptothecin	1184,1206	p53	1124,1127	10-hydroxycamptothecin	p53	MESH:C028098	7157	Chemical	Gene	agents|dep|START_ENTITY potentiated|nmod|agents potentiated|dobj|effects effects|nmod|activation activation|compound|END_ENTITY	The antisense oligonucleotides also potentiated the effects of p53 activation and p21 induction by chemotherapeutic agents 10-hydroxycamptothecin , adriamycin , 5-fluorouracil , and paclitaxel .
25523336	0	10-hydroxycamptothecin	106,128	RPL13A	0,6	10-hydroxycamptothecin	RPL13A	MESH:C028098	23521	Chemical	Gene	paclitaxel|conj|START_ENTITY treatments|amod|paclitaxel normalizing|nmod|treatments gene|acl|normalizing END_ENTITY|nmod|gene	RPL13A as a reference gene for normalizing mRNA transcription of ovarian_cancer cells with paclitaxel and 10-hydroxycamptothecin treatments .
17482779	0	10-hydroxycamptothecin	73,95	serum_albumin	117,130	10-hydroxycamptothecin	serum albumin	MESH:C028098	24186(Tax:10116)	Chemical	Gene	form|nmod|START_ENTITY Preparation|nmod|form Preparation|dep|END_ENTITY	Preparation , characterization and biodistribution of the lactone form of 10-hydroxycamptothecin -LRB- HCPT -RRB- - loaded bovine serum_albumin -LRB- BSA -RRB- nanoparticles .
8355258	0	10-hydroxycamptothecin	62,84	serum_albumin	110,123	10-hydroxycamptothecin	serum albumin	MESH:C028098	213	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum_albumin .
11589502	1	10-hydroxycamptothecin	99,121	SRB	246,249	10-hydroxycamptothecin	SRB	MESH:C028098	10575	Chemical	Gene	potential|nmod|START_ENTITY investigate|dobj|potential detected|advcl|investigate detected|nmod|assay assay|compound|END_ENTITY	To investigate the antiangiogenic potential of 10-hydroxycamptothecin -LRB- HCPT -RRB- , the proliferation of human microvascular endothelial cells -LRB- HMEC -RRB- and seven human tumor cell lines were detected by SRB assay , and the endothelial cell migration and tube formation were assessed using two in vitro model systems .
27470413	11	10-hydroxy_camptothecin	1694,1717	Ch-1	1606,1610	10-hydroxy camptothecin	Ch-1	MESH:C028098	51430	Chemical	Gene	effect|nmod|START_ENTITY enhanced|dobj|effect enhanced|nsubj|END_ENTITY	Amazingly , Ch-1 at non-toxic concentration -LRB- 2.5-10 M -RRB- enhanced significantly anti-cancer effect of 10-hydroxy_camptothecin -LRB- HCPT -RRB- on Hela , BGC823 , and MCF-7 cells .
23498119	1	10-hydroxy_camptothecin	185,208	serum_albumin	229,242	10-hydroxy camptothecin	serum albumin	MESH:C028098	213	Chemical	Gene	drug|dep|START_ENTITY graphene_oxide|conj|drug graphene_oxide|conj|END_ENTITY	The interaction of graphene_oxide -LRB- GO -RRB- , a medicinal drug -LRB- 10-hydroxy_camptothecin -LRB- HCPT -RRB- -RRB- , and bovine serum_albumin -LRB- BSA -RRB- was investigated with the aim of developing a method for the analysis of serum_albumin proteins .
23498119	1	10-hydroxy_camptothecin	185,208	serum_albumin	322,335	10-hydroxy camptothecin	serum albumin	MESH:C028098	213	Chemical	Gene	drug|dep|START_ENTITY graphene_oxide|conj|drug interaction|nmod|graphene_oxide investigated|nsubjpass|interaction investigated|nmod|aim aim|acl|developing developing|nmod|analysis analysis|nmod|proteins proteins|compound|END_ENTITY	The interaction of graphene_oxide -LRB- GO -RRB- , a medicinal drug -LRB- 10-hydroxy_camptothecin -LRB- HCPT -RRB- -RRB- , and bovine serum_albumin -LRB- BSA -RRB- was investigated with the aim of developing a method for the analysis of serum_albumin proteins .
26639236	0	10-Hydroxycamptothecin	0,22	caspase_3	110,119	10-Hydroxycamptothecin	caspase 3	MESH:C028098	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|p53 p53|conj|END_ENTITY	10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways .
26639236	0	10-Hydroxycamptothecin	0,22	cytochrome_c	92,104	10-Hydroxycamptothecin	cytochrome c	MESH:C028098	54205	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|p53 p53|conj|END_ENTITY	10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways .
28097065	0	10-Hydroxycamptothecin	24,46	NOXA	16,20	10-Hydroxycamptothecin	NOXA	MESH:C028098	492821(Tax:10116)	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing_epidural_fibrosis .
26639236	0	10-Hydroxycamptothecin	0,22	p53	87,90	10-Hydroxycamptothecin	p53	MESH:C028098	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathways pathways|amod|END_ENTITY	10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53 , cytochrome_c and caspase_3 pathways .
11270977	1	10-Hydroxycamptothecin	161,183	ST1435	210,216	10-Hydroxycamptothecin	ST1435	MESH:C028098	1459466(Tax:273063)	Chemical	Gene	START_ENTITY|conj|19-norprogesteron 19-norprogesteron|appos|END_ENTITY	AIM : Genotoxicity evaluations of several different chemicals including L-4-oxalysine , 10-Hydroxycamptothecin -LRB- HCT -RRB- , 19-norprogesteron -LRB- ST1435 -RRB- , dimethyl_sulfoxide -LRB- Me2SO -RRB- , bleomycin -LRB- BLM -RRB- , and mitomycin_C -LRB- MMC -RRB- .
25505251	4	10-Hydroxy-cis-12-octadecenoic_acid	641,676	occludin	832,840	10-Hydroxy-cis-12-octadecenoic acid	occludin	null	18260(Tax:10090)	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|changes changes|nmod|expression expression|nmod|molecules molecules|conj|END_ENTITY	10-Hydroxy-cis-12-octadecenoic_acid -LRB- HYA -RRB- , a gut microbial metabolite of linoleic_acid , suppressed TNF-a and dextran sulfate sodium-induced changes in the expression of TJ-related molecules , occludin , zonula occludens-1 , and myosin light chain kinase .
25505251	4	10-Hydroxy-cis-12-octadecenoic_acid	641,676	TNF-a	740,745	10-Hydroxy-cis-12-octadecenoic acid	TNF-a	null	21926(Tax:10090)	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|changes changes|amod|END_ENTITY	10-Hydroxy-cis-12-octadecenoic_acid -LRB- HYA -RRB- , a gut microbial metabolite of linoleic_acid , suppressed TNF-a and dextran sulfate sodium-induced changes in the expression of TJ-related molecules , occludin , zonula occludens-1 , and myosin light chain kinase .
8588874	7	10-hydroxydecanoic_acid	1392,1415	CDPK	1431,1435	10-hydroxydecanoic acid	CDPK	CHEBI:17409	543102(Tax:4565)	Chemical	Gene	12-Hydroxystearic_acid|conj|START_ENTITY inhibit|dep|12-Hydroxystearic_acid inhibit|dobj|END_ENTITY	12-Hydroxystearic_acid and 10-hydroxydecanoic_acid do not inhibit CDPK , PKC or MLCK but are selective inhibitors of cAK -LRB- IC50 values 127 and 138 microM , respectively -RRB- , consistent with a simple model for amphiphile inhibition of cAK involving two polar groups separated by a non-polar region .
27049436	4	10-hydroxydecanoic_acid	752,775	EC-SOD	922,928	10-hydroxydecanoic acid	EC-SOD	CHEBI:17409	6649	Chemical	Gene	constituents|amod|START_ENTITY effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|END_ENTITY	Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells .
23995057	0	10-hydroxydecanoic_acid	21,44	interferon_regulatory_factor-1	135,165	10-hydroxydecanoic acid	interferon regulatory factor-1	CHEBI:17409	16362(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|macrophages macrophages|amod|END_ENTITY	Inhibitory effect of 10-hydroxydecanoic_acid on lipopolysaccharide-induced nitric_oxide production via translational downregulation of interferon_regulatory_factor-1 in RAW264 murine macrophages .
8588874	7	10-hydroxydecanoic_acid	1392,1415	MLCK	1444,1448	10-hydroxydecanoic acid	MLCK	CHEBI:17409	291926(Tax:10116)	Chemical	Gene	12-Hydroxystearic_acid|conj|START_ENTITY inhibit|dep|12-Hydroxystearic_acid inhibit|dobj|CDPK CDPK|conj|END_ENTITY	12-Hydroxystearic_acid and 10-hydroxydecanoic_acid do not inhibit CDPK , PKC or MLCK but are selective inhibitors of cAK -LRB- IC50 values 127 and 138 microM , respectively -RRB- , consistent with a simple model for amphiphile inhibition of cAK involving two polar groups separated by a non-polar region .
27049436	4	10-hydroxydecanoic_acid	752,775	THP-1	932,937	10-hydroxydecanoic acid	THP-1	CHEBI:17409	2736	Chemical	Gene	constituents|amod|START_ENTITY effects|nmod|constituents evaluated|dobj|effects evaluated|nmod|expression expression|nmod|EC-SOD EC-SOD|nmod|cells cells|compound|END_ENTITY	Therefore , we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic_acid -LRB- 10HDA , 1 -RRB- , sebacic_acid -LRB- SA , 3 -RRB- , and 4-hydroperoxy-2-decenoic_acid_ethyl_ester -LRB- 4-HPO-DAEE , 4 -RRB- , which is a derivative of 2 , on the expression of EC-SOD in THP-1 cells .
17992728	13	10-hydroxyfenchol	1679,1696	min-1	1806,1811	10-hydroxyfenchol	min-1	MESH:C052091	966	Chemical	Gene	hydroxyfenchol|conj|START_ENTITY _|amod|hydroxyfenchol formation|nmod|_ values|nmod|formation 0.06|nsubj|values showed|ccomp|0.06 showed|conj|2.94 2.94|conj|P450 P450|amod|END_ENTITY	Kinetic analysis showed that the Km values for the formation of fenchone , 6-exo - _ hydroxyfenchol and 10-hydroxyfenchol in rats treated with phenobarbital were 0.06 , 0.03 and 0.03 mM , and Vmax values were 2.94 , 6.1 and 13.8 nmol min-1 nmol-1 P450 , respectively .
17992728	13	10-hydroxyfenchol	1679,1696	P450	1819,1823	10-hydroxyfenchol	P450	MESH:C052091	1555	Chemical	Gene	hydroxyfenchol|conj|START_ENTITY _|amod|hydroxyfenchol formation|nmod|_ values|nmod|formation 0.06|nsubj|values showed|ccomp|0.06 showed|conj|2.94 2.94|conj|END_ENTITY	Kinetic analysis showed that the Km values for the formation of fenchone , 6-exo - _ hydroxyfenchol and 10-hydroxyfenchol in rats treated with phenobarbital were 0.06 , 0.03 and 0.03 mM , and Vmax values were 2.94 , 6.1 and 13.8 nmol min-1 nmol-1 P450 , respectively .
17142962	3	10-hydroxyfenchone	362,380	P450	407,411	10-hydroxyfenchone	P450	MESH:C052091	1555	Chemical	Gene	6-exo-hydroxyfenchone|conj|START_ENTITY 6-exo-hydroxyfenchone|nmod|enzymes enzymes|compound|END_ENTITY	-LRB- + -RRB- - Fenchone was found to be oxidized to 6-exo-hydroxyfenchone , 6-endo-hydroxyfenchone and 10-hydroxyfenchone by human liver microsomal P450 enzymes .
17484521	3	10-hydroxyfenchone	366,384	P450	411,415	10-hydroxyfenchone	P450	MESH:C052091	1555	Chemical	Gene	6-exo-hydroxyfenchone|conj|START_ENTITY 6-exo-hydroxyfenchone|nmod|enzymes enzymes|compound|END_ENTITY	-LRB- - -RRB- - Fenchone was found to be oxidized to 6-exo-hydroxyfenchone , 6-endo-hydroxyfenchone and 10-hydroxyfenchone by human liver microsomal P450 enzymes .
18033743	6	10-hydroxygambogic_acid	733,756	GBA	827,830	10-hydroxygambogic acid	GBA	MESH:C550001	684536(Tax:10116)	Chemical	Gene	acid|amod|START_ENTITY metabolites|appos|acid oxides|nsubj|metabolites oxides|nmod|bond bond|nmod|END_ENTITY	Two phase I metabolites , 10-hydroxygambogic_acid and 9,10-epoxygambogic _ acid , were oxides on the 9,10-olefinic bond of GBA .
7726550	5	10-hydroxygeraniol	722,740	C-1_and_C-10	823,835	10-hydroxygeraniol	C-1 and C-10	MESH:C471578	3183;3226	Chemical	Gene	that|amod|START_ENTITY oxidized|nsubjpass|that oxidized|nmod|END_ENTITY	Gas chromatographic and coupled mass spectrometric analysis of the reaction products showed that 10-hydroxygeraniol and 10-hydroxynerol were oxidized by the enzyme in the presence of NADP + , at both C-1_and_C-10 .
20456828	4	10-hydroxyisorhynchophylline	646,674	MI2	584,587	10-hydroxyisorhynchophylline	MI2	null	117535(Tax:10116)	Chemical	Gene	plasma|conj|START_ENTITY plasma|conj|D-glucuronide D-glucuronide|appos|END_ENTITY	RESULTS : ISOR was identified in plasma , 11-hydroxyisorhynchophylline_11-O -- D-glucuronide -LRB- MI1 -RRB- and 10-hydroxyisorhynchophylline_10-O -- D-glucuronide -LRB- MI2 -RRB- in bile , and free 11-hydroxyisorhynchophylline -LRB- MI3 -RRB- and 10-hydroxyisorhynchophylline -LRB- MI4 -RRB- in urine and feces .
10192963	1	10-hydroxyl	261,272	O-acetyltransferase	146,165	10-hydroxyl	O-acetyltransferase	null	64921	Chemical	Gene	group|amod|START_ENTITY possessing|dobj|group taxanes|acl|possessing range|nmod|taxanes acetylation|nmod|range catalyzes|dobj|acetylation END_ENTITY|acl:relcl|catalyzes	An O-acetyltransferase that catalyzes the regiospecific acetylation of a range of taxanes possessing an unsubstituted 10-hydroxyl group was detected and purified to apparent electrophoretic homogeneity from a cytosolic fraction of Taxus chinensis cell cultures .
23169608	6	10-hydroxy-NBP	924,938	M3-1	917,921	10-hydroxy-NBP	M3-1	null	10951	Chemical	Gene	M3-2|amod|START_ENTITY M2|conj|M3-2 M2|conj|END_ENTITY	10-Keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- , and M5-2 were the major circulating metabolites , wherein the areas under the curve values were 1.6 - , 2.9 - , 10.3 - , and 4.1-fold higher than that of NBP .
23434525	2	10-hydroxy-NBP	393,407	M3-1	386,390	10-hydroxy-NBP	M3-1	null	10951	Chemical	Gene	10-keto-NBP|conj|START_ENTITY 10-keto-NBP|conj|3-hydroxy-NBP 3-hydroxy-NBP|appos|END_ENTITY	Our previous study showed that NBP underwent extensive metabolism in humans and that 10-keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- and NBP-11-oic_acid -LRB- M5-2 -RRB- were the major circulating metabolites .
15180333	13	10-hydroxynortriptyline	1601,1624	CYP2D6	1688,1694	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|conj|START_ENTITY profiles|amod|nortriptyline summarized|nmod|profiles summarized|nmod|number number|nmod|copies copies|compound|END_ENTITY	The VizStruct visualization succinctly summarized the salient similarities and differences in the nortriptyline and 10-hydroxynortriptyline pharmacokinetic profiles in subjects with increasing number of CYP2D6 gene copies .
15180333	7	10-hydroxynortriptyline	923,946	CYP2D6	1009,1015	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	metabolite|amod|START_ENTITY nortriptyline|conj|metabolite kinetics|nmod|nortriptyline 63:444|nmod|kinetics subjects|nsubj|63:444 subjects|nmod|number number|nmod|copies copies|nmod|END_ENTITY	63:444 -452 , 1998 -RRB- on the kinetics of nortriptyline and its 10-hydroxynortriptyline metabolite in subjects with differing number of copies of the CYP2D6 , and the gene expression profiling data of Bohen and colleagues -LRB- Proc .
24257813	6	10-hydroxynortriptyline	1072,1095	CYP2D6	1004,1010	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|conj|START_ENTITY concentrations|amod|nortriptyline associated|nmod|concentrations associated|nsubjpass|genotype genotype|compound|END_ENTITY	For those taking nortriptyline -LRB- n = 161 -RRB- , the CYP2D6 genotype was significantly associated with nortriptyline and 10-hydroxynortriptyline serum concentrations and 10-hydroxynortriptyline : nortrip-tyline ratio .
24257813	6	10-hydroxynortriptyline	1121,1144	CYP2D6	1004,1010	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	concentrations|conj|START_ENTITY associated|nmod|concentrations associated|nsubjpass|genotype genotype|compound|END_ENTITY	For those taking nortriptyline -LRB- n = 161 -RRB- , the CYP2D6 genotype was significantly associated with nortriptyline and 10-hydroxynortriptyline serum concentrations and 10-hydroxynortriptyline : nortrip-tyline ratio .
28133768	0	10-hydroxynortriptyline	76,99	CYP2D6	14,20	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	levels|amod|START_ENTITY patients|nmod|levels paroxetine|nmod|patients dose|amod|paroxetine END_ENTITY|nmod|dose	Inhibition of CYP2D6 with low dose -LRB- 5 mg -RRB- paroxetine in patients with high 10-hydroxynortriptyline serum levels - a review of routine practice .
8867869	1	10-hydroxynortriptyline	242,265	CYP2D6	141,147	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|conj|START_ENTITY levels|nmod|nortriptyline relationship|conj|levels relationship|nmod|genotype genotype|compound|END_ENTITY	The relationship between the CYP2D6 genotype and the steady state plasma levels of nortriptyline -LRB- NT -RRB- , its main active metabolite 10-hydroxynortriptyline -LRB- 10-OH-NT -RRB- and the NT/10-OH-NT ratio were studied in 21 Caucasian depressed patients treated with 100-150 mg NT daily .
9585799	8	10-hydroxynortriptyline	2234,2257	CYP2D6	2111,2117	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|conj|START_ENTITY pharmacokinetics|nmod|nortriptyline show|nmod|pharmacokinetics show|dobj|importance importance|nmod|genotype genotype|compound|END_ENTITY	CONCLUSION : The results of this study show the quantitative importance of the CYP2D6 genotype , especially the presence of multiple functional CYP2D6 genes for the pharmacokinetics of nortriptyline and 10-hydroxynortriptyline .
9585799	8	10-hydroxynortriptyline	2234,2257	CYP2D6	2175,2181	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|conj|START_ENTITY pharmacokinetics|nmod|nortriptyline show|nmod|pharmacokinetics show|dobj|importance importance|dep|presence presence|nmod|genes genes|compound|END_ENTITY	CONCLUSION : The results of this study show the quantitative importance of the CYP2D6 genotype , especially the presence of multiple functional CYP2D6 genes for the pharmacokinetics of nortriptyline and 10-hydroxynortriptyline .
9797795	6	10-hydroxynortriptyline	1136,1159	CYP2D6	1251,1257	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	lower|advcl|START_ENTITY lower|conj|was was|advmod|longer longer|nmod|subjects subjects|acl:relcl|homozygous homozygous|nmod|END_ENTITY	For 10-hydroxynortriptyline , the AUC was lower and the plasma half-life was longer in subjects who were homozygous for CYP2D6 * 10 than in subjects in the other 2 groups .
9797795	7	10-hydroxynortriptyline	1514,1537	CYP2D6	1317,1323	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele CYP2D6|acl|* associated|advcl|CYP2D6 CONCLUSION|dep|associated CONCLUSION|dep|END_ENTITY	CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype .
9797795	7	10-hydroxynortriptyline	1514,1537	CYP2D6	1444,1450	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele END_ENTITY|acl|*	CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype .
9797795	7	10-hydroxynortriptyline	1514,1537	CYP2D6	1577,1583	10-hydroxynortriptyline	CYP2D6	MESH:C013567	1565	Chemical	Gene	nortriptyline|nmod|START_ENTITY metabolism|nmod|nortriptyline allele|nmod|metabolism *|dobj|allele *|advmod|particularly particularly|nmod|subjects subjects|nmod|END_ENTITY	CONCLUSION : The CYP2D6 * 10 allele in Chinese subjects was associated with significantly higher plasma levels of nortriptyline compared with the CYP2D6 * 1 allele because of an impaired metabolism of nortriptyline to 10-hydroxynortriptyline , particularly in the subjects with the CYP2D6 * 10 / * 10 genotype .
7105623	8	10-hydroxynortriptyline	1342,1365	min-1	1387,1392	10-hydroxynortriptyline	min-1	MESH:C013567	966	Chemical	Gene	clearance|nmod|START_ENTITY /|nsubj|clearance /|parataxis|removed removed|nsubjpass|8 8|amod|END_ENTITY	Dialysis clearance of conjugated 10-hydroxynortriptyline was 58 + / - 8 -LRB- SD -RRB- ml min-1 , but nortriptyline and unconjugated 10-hydroxynortriptyline were not appreciably removed by dialysis .
7105623	8	10-hydroxynortriptyline	1429,1452	min-1	1387,1392	10-hydroxynortriptyline	min-1	MESH:C013567	966	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Dialysis clearance of conjugated 10-hydroxynortriptyline was 58 + / - 8 -LRB- SD -RRB- ml min-1 , but nortriptyline and unconjugated 10-hydroxynortriptyline were not appreciably removed by dialysis .
25505251	10	10-hydroxyoctadacanoic_acid	1491,1518	GPR40	1688,1693	10-hydroxyoctadacanoic acid	GPR40	null	2864	Chemical	Gene	show|nsubj|START_ENTITY show|dobj|activities activities|conj|expression expression|compound|END_ENTITY	Conversely , 10-hydroxyoctadacanoic_acid , which is a gut microbial metabolite of oleic_acid and lacks a carbon-carbon double bond at 12 position , did not show these TJ-restoring activities and down-regulated GPR40 expression .
26711482	3	10-hydroxyoxcarbazepine	758,781	CYP1A2	579,585	10-hydroxyoxcarbazepine	CYP1A2	null	1544	Chemical	Gene	induce|nsubj|START_ENTITY determined|advcl|induce determined|nmod|END_ENTITY	For the CYP1A2 the induction potential determined as the fold change in mRNA levels was 7.2 -LRB- range : 2.3-11 .5 -RRB- and 10.0 -LRB- 6.2-13 .7 -RRB- for oxcarbazepine and carbamazepine , respectively , while 10-hydroxyoxcarbazepine did not induce .
26711482	2	10-hydroxyoxcarbazepine	384,407	CYP2B6	471,477	10-hydroxyoxcarbazepine	CYP2B6	null	1555	Chemical	Gene	metabolite|amod|START_ENTITY oxcarbazepine|appos|metabolite potentials|nmod|oxcarbazepine evaluated|nsubjpass|potentials evaluated|nmod|_ _|dep|levels levels|amod|_ _|dep|1A2 1A2|nummod|END_ENTITY	Auto-induction potentials of oxcarbazepine , its pharmacologically active metabolite 10-hydroxyoxcarbazepine and carbamazepine were evaluated by cytochrome_P450 _ -LRB- CYP -RRB- _ 1A2 , CYP2B6 and CYP3A4 mRNA levels and primary metabolic rates using human hepatocytes and HepaRG cells .
26711482	4	10-hydroxyoxcarbazepine	915,938	CYP2B6	833,839	10-hydroxyoxcarbazepine	CYP2B6	null	1555	Chemical	Gene	11.5|amod|START_ENTITY 11.5|nsubj|change change|nmod|levels levels|nmod|END_ENTITY	The fold change in mRNA levels for CYP2B6 was 11.5 -LRB- 3.2-19 .3 -RRB- , 7.0 -LRB- 2.5-10 .8 -RRB- and 14.8 -LRB- 3.1-29 .1 -RRB- for oxcarbazepine , 10-hydroxyoxcarbazepine and carbamazepine , respectively .
26711482	2	10-hydroxyoxcarbazepine	384,407	CYP3A4	482,488	10-hydroxyoxcarbazepine	CYP3A4	null	1576	Chemical	Gene	metabolite|amod|START_ENTITY oxcarbazepine|appos|metabolite potentials|nmod|oxcarbazepine evaluated|nsubjpass|potentials evaluated|nmod|_ _|dep|levels levels|amod|_ _|dep|1A2 1A2|conj|END_ENTITY	Auto-induction potentials of oxcarbazepine , its pharmacologically active metabolite 10-hydroxyoxcarbazepine and carbamazepine were evaluated by cytochrome_P450 _ -LRB- CYP -RRB- _ 1A2 , CYP2B6 and CYP3A4 mRNA levels and primary metabolic rates using human hepatocytes and HepaRG cells .
26711482	5	10-hydroxyoxcarbazepine	1033,1056	CYP3A4	992,998	10-hydroxyoxcarbazepine	CYP3A4	null	1576	Chemical	Gene	oxcarbazepine|conj|START_ENTITY level|acl|oxcarbazepine level|dep|change change|nmod|END_ENTITY	The fold change for CYP3A4 induction level by oxcarbazepine , 10-hydroxyoxcarbazepine and carbamazepine was 3.5 -LRB- 1.2-7 .4 -RRB- , 2.7 -LRB- 0.8-5 .7 -RRB- and 8.3 -LRB- 3.5-14 .5 -RRB- , respectively .
26711482	0	10-hydroxyoxcarbazepine	79,102	P450	25,29	10-hydroxyoxcarbazepine	P450	null	1555	Chemical	Gene	drug|amod|START_ENTITY inductions|nmod|drug inductions|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine , 10-hydroxyoxcarbazepine , and carbamazepine using human hepatocytes and HepaRG cells .
16501007	11	10-hydroxyrutaecarpine	1352,1374	CYP1A1	1385,1391	10-hydroxyrutaecarpine	CYP1A1	null	1543	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY	The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation .
16501007	11	10-hydroxyrutaecarpine	1352,1374	CYP1A2	1393,1399	10-hydroxyrutaecarpine	CYP1A2	null	1544	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|CYP1A1 CYP1A1|conj|END_ENTITY	The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation .
16501007	11	10-hydroxyrutaecarpine	1352,1374	CYP1B1	1405,1411	10-hydroxyrutaecarpine	CYP1B1	null	1545	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|CYP1A1 CYP1A1|conj|activities activities|nummod|END_ENTITY	The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1 , CYP1A2 , and CYP1B1 activities with respective IC -LRB- 50 -RRB- values of 2.56 + / - 0.04 , 2.57 + / - 0.11 , and 0.09 + / - 0.01 microM , suggesting that product inhibition might occur during rutaecarpine hydroxylation .
24958911	6	10-hydroxystearamide	856,876	EPHX1	839,844	10-hydroxystearamide	EPHX1	MESH:C052091	2052	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A selective EPHX1 inhibitor , 10-hydroxystearamide , inhibited 2-AG metabolism and hydrolysis of a well-known EPHX1 substrate , cis-stilbene_oxide .
24958911	6	10-hydroxystearamide	856,876	EPHX1	935,940	10-hydroxystearamide	EPHX1	MESH:C052091	2052	Chemical	Gene	inhibitor|amod|START_ENTITY inhibited|nsubj|inhibitor inhibited|dobj|metabolism metabolism|conj|hydrolysis hydrolysis|nmod|substrate substrate|compound|END_ENTITY	A selective EPHX1 inhibitor , 10-hydroxystearamide , inhibited 2-AG metabolism and hydrolysis of a well-known EPHX1 substrate , cis-stilbene_oxide .
16348853	5	10-hydroxystearic_acid	512,534	B-3266	744,750	10-hydroxystearic acid	B-3266	MESH:C070376	947768(Tax:511145)	Chemical	Gene	hydrations|acl|START_ENTITY stereochemistries|nmod|hydrations stereochemistries|dep|ATCC ATCC|conj|END_ENTITY	This report describes the stereochemistries of microbial hydrations of oleic_acid to 10-hydroxystearic_acid by Nocardia_aurantia -LRB- also known as Rhodococcus_rhodochrous -RRB- ATCC 12674 , Nocardia restrictus ATCC 14887 , Mycobacterium_fortuitum UI-53387 , Pseudomonas species strain NRRL-2994 , Pseudomonas species strain NRRL B-3266 , and baker 's _ yeast .
22189865	0	10-hydroxystearic_acid	14,36	oleate_hydratase	85,101	10-hydroxystearic acid	oleate hydratase	MESH:C070376	29443290	Chemical	Gene	Production|nmod|START_ENTITY hydrolyzate|nsubj|Production hydrolyzate|nmod|END_ENTITY	Production of 10-hydroxystearic_acid from oleic_acid and olive oil hydrolyzate by an oleate_hydratase from Lysinibacillus_fusiformis .
21948282	0	10-hydroxy-trans-2-decenoic_acid	21,53	IkB	98,101	10-hydroxy-trans-2-decenoic acid	IkB	null	18036(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|acl|reducing reducing|dobj|END_ENTITY	Inhibitory effect of 10-hydroxy-trans-2-decenoic_acid on LPS-induced IL-6 production via reducing IkB - expression .
21948282	0	10-hydroxy-trans-2-decenoic_acid	21,53	IL-6	69,73	10-hydroxy-trans-2-decenoic acid	IL-6	null	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Inhibitory effect of 10-hydroxy-trans-2-decenoic_acid on LPS-induced IL-6 production via reducing IkB - expression .
12867494	2	10-hydroxyverbenone	409,428	p450	474,478	10-hydroxyverbenone	p450	MESH:C000589000	1555	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	In this study , -LRB- - -RRB- - verbenone was found to be converted to 10-hydroxyverbenone by rat and human liver microsomal cytochrome p450 -LRB- p450 -RRB- enzymes .
12867494	2	10-hydroxyverbenone	409,428	p450	480,484	10-hydroxyverbenone	p450	MESH:C000589000	1555	Chemical	Gene	enzymes|amod|START_ENTITY enzymes|appos|END_ENTITY	In this study , -LRB- - -RRB- - verbenone was found to be converted to 10-hydroxyverbenone by rat and human liver microsomal cytochrome p450 -LRB- p450 -RRB- enzymes .
9014207	2	10-hydroxywarfarin	256,274	CYP1A2	207,213	10-hydroxywarfarin	CYP1A2	MESH:C065719	1544	Chemical	Gene	CYP3A4|nmod|START_ENTITY metabolized|nmod|CYP3A4 metabolized|nmod|6 6|compound|END_ENTITY	R-warfarin is metabolized primarily by CYP1A2 to 6 - _ and_8-hydroxywarfarin , by CYP3A4 to 10-hydroxywarfarin , and by carbonyl reductases to diastereoisomeric alcohols .
16035367	2	10-hydroxywarfarin	337,355	CYP3A4	270,276	10-hydroxywarfarin	CYP3A4	MESH:C065719	1576	Chemical	Gene	quantitation|amod|START_ENTITY determined|nmod|quantitation determined|nsubjpass|activity activity|compound|END_ENTITY	CYP3A4 activity was determined by the quantitation of the product , 10-hydroxywarfarin , based on separation by CE .
9014207	2	10-hydroxywarfarin	256,274	CYP3A4	246,252	10-hydroxywarfarin	CYP3A4	MESH:C065719	1576	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	R-warfarin is metabolized primarily by CYP1A2 to 6 - _ and_8-hydroxywarfarin , by CYP3A4 to 10-hydroxywarfarin , and by carbonyl reductases to diastereoisomeric alcohols .
17921187	8	10-hydroxywarfarin	1606,1624	UGT	1514,1517	10-hydroxywarfarin	UGT	MESH:C065719	7361	Chemical	Gene	evaluated|conj|START_ENTITY isozymes|dep|evaluated isozymes|nsubj|none none|nmod|END_ENTITY	UGT1A4 , 1A6 , 1A7 , and 2B7 did not have activity with any substrate , and none of the UGT isozymes evaluated catalyzed reactions with -LRB- R -RRB- - and -LRB- S -RRB- - warfarin , racemic warfarin , or 10-hydroxywarfarin .
17921187	8	10-hydroxywarfarin	1606,1624	UGT1A4	1430,1436	10-hydroxywarfarin	UGT1A4	MESH:C065719	54657	Chemical	Gene	evaluated|conj|START_ENTITY isozymes|dep|evaluated have|conj|isozymes have|nsubj|END_ENTITY	UGT1A4 , 1A6 , 1A7 , and 2B7 did not have activity with any substrate , and none of the UGT isozymes evaluated catalyzed reactions with -LRB- R -RRB- - and -LRB- S -RRB- - warfarin , racemic warfarin , or 10-hydroxywarfarin .
20429590	11	10-Hydroxywarfarin	1649,1667	CYP2C9	1773,1779	10-Hydroxywarfarin	CYP2C9	MESH:C065719	1559	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	10-Hydroxywarfarin , which has been reported as the second most abundant plasma metabolite , was the most potent inhibitor of CYP2C9 , displaying approximately 3-fold higher affinity than S-warfarin .
23434525	2	10-keto-NBP	353,364	M3-1	386,390	10-keto-NBP	M3-1	null	10951	Chemical	Gene	START_ENTITY|conj|3-hydroxy-NBP 3-hydroxy-NBP|appos|END_ENTITY	Our previous study showed that NBP underwent extensive metabolism in humans and that 10-keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- and NBP-11-oic_acid -LRB- M5-2 -RRB- were the major circulating metabolites .
23169608	6	10-Keto-NBP	884,895	M3-1	917,921	10-Keto-NBP	M3-1	null	10951	Chemical	Gene	M2|amod|START_ENTITY M2|conj|END_ENTITY	10-Keto-NBP -LRB- M2 -RRB- , 3-hydroxy-NBP -LRB- M3-1 -RRB- , 10-hydroxy-NBP -LRB- M3-2 -RRB- , and M5-2 were the major circulating metabolites , wherein the areas under the curve values were 1.6 - , 2.9 - , 10.3 - , and 4.1-fold higher than that of NBP .
25847254	3	10-MDP	538,544	COX-2	616,621	10-MDP	COX-2	null	4513	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
25847254	4	10-MDP	701,707	dentin_matrix_protein-1	876,899	10-MDP	dentin matrix protein-1	null	1758	Chemical	Gene	alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|amod|END_ENTITY	In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity .
26864705	4	10-MDP	708,714	HAp	849,852	10-MDP	HAp	null	10313	Chemical	Gene	monomers|appos|START_ENTITY either|nmod|monomers containing|dobj|either measured|advcl|containing measured|nmod|with with|conj|powder powder|compound|END_ENTITY	The DC of three experimental adhesive formulations , containing either of the two functional monomers -LSB- 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- 10-MDP -RRB- or 4-methacryloxyethyl_trimellitic_acid_anhydride -LRB- 4-META -RRB- -RSB- or no functional monomer -LRB- no-FM ; control -RRB- , was measured with and without HAp powder added to the adhesive formulations .
25847254	5	10-MDP	987,993	heme_oxygenase-1	1079,1095	10-MDP	heme oxygenase-1	null	3162	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|conj|END_ENTITY	In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- .
25847254	5	10-MDP	987,993	HO-1	1097,1101	10-MDP	HO-1	null	3162	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|appos|END_ENTITY	In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- .
25847254	6	10-MDP	1139,1145	HO-1	1174,1178	10-MDP	HO-1	null	3162	Chemical	Gene	effect|nmod|START_ENTITY related|nsubjpass|effect related|nmod|induction induction|nmod|END_ENTITY	We evaluated whether the effect of 10-MDP was related to induction of HO-1 , and found that treatment with a selective inhibitor of HO-1 reversed production of 10-MDP-mediated pro-inflammatory cytokines and inhibition of differentiation markers .
25847254	6	10-MDP	1139,1145	HO-1	1235,1239	10-MDP	HO-1	null	3162	Chemical	Gene	effect|nmod|START_ENTITY related|nsubjpass|effect related|conj|found found|ccomp|reversed reversed|nsubj|treatment treatment|nmod|inhibitor inhibitor|nmod|END_ENTITY	We evaluated whether the effect of 10-MDP was related to induction of HO-1 , and found that treatment with a selective inhibitor of HO-1 reversed production of 10-MDP-mediated pro-inflammatory cytokines and inhibition of differentiation markers .
25847254	8	10-MDP	1596,1602	HO-1	1718,1722	10-MDP	HO-1	null	3162	Chemical	Gene	concentrations|nmod|START_ENTITY promoted|nsubj|concentrations promoted|advcl|activating activating|dobj|induction induction|amod|END_ENTITY	Taken together , the results of this study showed that minimally toxic concentrations of 10-MDP promoted an inflammatory response and suppresses odontoblastic differentiation of DPCs by activating Nrf2-mediated HO-1 induction through MAPK and NF-kB signalling .
25847254	3	10-MDP	538,544	IL-1b	630,635	10-MDP	IL-1b	null	3553	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
25847254	3	10-MDP	538,544	IL-6	637,641	10-MDP	IL-6	null	3569	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
25847254	3	10-MDP	538,544	IL-8	646,650	10-MDP	IL-8	null	3576	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
25847254	3	10-MDP	538,544	iNOS	610,614	10-MDP	iNOS	null	51477	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
25847254	5	10-MDP	987,993	Nrf2	1052,1056	10-MDP	Nrf2	null	4780	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|nuclear_factor-E2-related_factor_2 nuclear_factor-E2-related_factor_2|appos|END_ENTITY	In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- .
25847254	5	10-MDP	987,993	nuclear_factor-E2-related_factor_2	1016,1050	10-MDP	nuclear factor-E2-related factor 2	null	4780	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|nmod|END_ENTITY	In addition , 10-MDP induced activation of nuclear_factor-E2-related_factor_2 -LRB- Nrf2 -RRB- and its target gene , heme_oxygenase-1 -LRB- HO-1 -RRB- .
25847254	4	10-MDP	701,707	osterix	901,908	10-MDP	osterix	null	121340	Chemical	Gene	alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|conj|END_ENTITY	In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity .
25847254	4	10-MDP	701,707	Runx2	913,918	10-MDP	Runx2	null	860	Chemical	Gene	alkaline|nummod|START_ENTITY phosphatase|nsubj|alkaline phosphatase|nmod|markers markers|nmod|sialophosphoprotein sialophosphoprotein|conj|END_ENTITY	In addition , 10-MDP reduced alkaline phosphatase activity , mineralization nodule formation and mRNA expression of odontoblastic differentiation markers such as dentin sialophosphoprotein , dentin_matrix_protein-1 , osterix and Runx2 in a concentration-dependent manner with low toxicity .
25847254	3	10-MDP	538,544	TNF-a	623,628	10-MDP	TNF-a	null	7124	Chemical	Gene	caused|nsubj|START_ENTITY caused|dobj|release release|nmod|cytokines cytokines|nmod|NO NO|conj|END_ENTITY	We found that 10-MDP caused the release of inflammatory cytokines including NO , PGE2 , iNOS , COX-2 , TNF-a , IL-1b , IL-6 and IL-8 in a concentration-dependent manner .
18205319	10	10-MeBaA	1565,1573	AhR	1699,1702	10-MeBaA	AhR	null	25690(Tax:10116)	Chemical	Gene	exception|nmod|START_ENTITY induced|nmod|exception induced|nmod|cells cells|acl:relcl|corresponded corresponded|nmod|END_ENTITY	With the exception of 10-MeBaA , all MeBaAs induced cell proliferation in contact-inhibited WB-F344 cells , which corresponded with their ability to activate AhR .
18205319	9	10-MeBaA	1393,1401	p53	1455,1458	10-MeBaA	p53	null	301300(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|apoptosis apoptosis|nmod|END_ENTITY	Only 10-MeBaA induced apoptosis and accumulation of phosphorylated p53 , which could be associated with the induction of oxidative stress , similar to DMBA .
26864705	4	10-methacryloyloxydecyl_dihydrogen_phosphate	662,706	HAp	849,852	10-methacryloyloxydecyl dihydrogen phosphate	HAp	MESH:C069749	10313	Chemical	Gene	monomers|amod|START_ENTITY either|nmod|monomers containing|dobj|either measured|advcl|containing measured|nmod|with with|conj|powder powder|compound|END_ENTITY	The DC of three experimental adhesive formulations , containing either of the two functional monomers -LSB- 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- 10-MDP -RRB- or 4-methacryloxyethyl_trimellitic_acid_anhydride -LRB- 4-META -RRB- -RSB- or no functional monomer -LRB- no-FM ; control -RRB- , was measured with and without HAp powder added to the adhesive formulations .
12238784	1	10-methacryloyloxydecyl_dihydrogen_phosphate	434,478	MDP	480,483	10-methacryloyloxydecyl dihydrogen phosphate	MDP	null	1800	Chemical	Gene	EP3MA|conj|START_ENTITY epithioalkyl_methacrylate|amod|EP3MA epithioalkyl_methacrylate|appos|END_ENTITY	To develop a new surface treatment agent which improves the bond strength of adhesive resin to both non-precious and precious metals , experimental treatment agents containing both an adhesive bonding promoter for precious metals and one for non-precious metals were prepared by dissolving epithioalkyl_methacrylate -LRB- EP3MA or EP8MA -RRB- and 10-methacryloyloxydecyl_dihydrogen_phosphate -LRB- MDP -RRB- in acetone .
26744836	10	10-methoxycamptothecin	1049,1071	OAT3	1154,1158	10-methoxycamptothecin	OAT3	MESH:C577311	9376	Chemical	Gene	10-hydroxycamptothecin|conj|START_ENTITY CPT|amod|10-hydroxycamptothecin inhibit|nsubj|CPT inhibit|dobj|activity activity|nmod|END_ENTITY	Our data revealed that CPT , 10-hydroxycamptothecin -LRB- HCPT -RRB- , 10-methoxycamptothecin -LRB- MCPT -RRB- and 9-nitrocamptothecin -LRB- 9NC -RRB- significantly inhibit the uptake activity of OAT3 .
22176677	7	10-methoxycanthin-6-one	1711,1734	cyclooxygenase_2	1572,1588	10-methoxycanthin-6-one	cyclooxygenase 2	null	19225(Tax:10090)	Chemical	Gene	IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|END_ENTITY	There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one .
22176677	7	10-methoxycanthin-6-one	1711,1734	IL-6	1655,1659	10-methoxycanthin-6-one	IL-6	null	16193(Tax:10090)	Chemical	Gene	END_ENTITY|advcl|START_ENTITY	There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one .
22176677	7	10-methoxycanthin-6-one	1711,1734	TNF	1619,1622	10-methoxycanthin-6-one	TNF	null	21926(Tax:10090)	Chemical	Gene	IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|cyclooxygenase_2 cyclooxygenase_2|dep|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|dep|END_ENTITY	There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one .
22176677	7	10-methoxycanthin-6-one	1711,1734	tumor_necrosis_factor_alpha	1590,1617	10-methoxycanthin-6-one	tumor necrosis factor alpha	null	21926(Tax:10090)	Chemical	Gene	IL-6|advcl|START_ENTITY b|conj|IL-6 levels|dep|b levels|nmod|synthase synthase|conj|cyclooxygenase_2 cyclooxygenase_2|dep|END_ENTITY	There was also a significant reduction in the mRNA levels of inducible nitric_oxide synthase , cyclooxygenase_2 , tumor_necrosis_factor_alpha -LRB- TNF -RRB- - a , and interleukin _ -LRB- IL -RRB- -1 b and IL-6 in LPS-stimulated macrophages after treatment with 10-methoxycanthin-6-one .
12932138	0	10-Methoxydihydrofuscin	0,23	CCR5	80,84	10-Methoxydihydrofuscin	CCR5	MESH:C479848	1234	Chemical	Gene	START_ENTITY|appos|antagonists antagonists|nmod|receptor receptor|compound|END_ENTITY	10-Methoxydihydrofuscin , fuscinarin , and fuscin , novel antagonists of the human CCR5 receptor from Oidiodendron griseum .
21463912	1	10-methoxyhomocamptothecin	291,317	hCPT	160,164	10-methoxyhomocamptothecin	hCPT	null	56994	Chemical	Gene	improve|advcl|START_ENTITY purpose|acl|improve designed|nmod|purpose designed|nsubjpass|series series|appos|END_ENTITY	A series of novel 7-acyl derivatives of homocamptothecin -LRB- hCPT -RRB- were designed and synthesized with the purpose to improve antitumor activity of hCPT , via Minisci free-radical reaction from 10-methoxyhomocamptothecin .
21463912	1	10-methoxyhomocamptothecin	291,317	hCPT	246,250	10-methoxyhomocamptothecin	hCPT	null	56994	Chemical	Gene	improve|advcl|START_ENTITY improve|dobj|activity activity|nmod|END_ENTITY	A series of novel 7-acyl derivatives of homocamptothecin -LRB- hCPT -RRB- were designed and synthesized with the purpose to improve antitumor activity of hCPT , via Minisci free-radical reaction from 10-methoxyhomocamptothecin .
2145423	7	10-methyl-11-hydroxyaporphine	1170,1199	PM-1000	1161,1168	10-methyl-11-hydroxyaporphine	PM-1000	MESH:C054813	1244347(Tax:272843)	Chemical	Gene	END_ENTITY|dep|START_ENTITY	On the other hand , serotonin1A_receptor agonists , -LRB- 8-hydroxy-2-di-n-propylaminotetralin , 100 and 300 micrograms/kg -RRB- and PM-1000 -LRB- 10-methyl-11-hydroxyaporphine , 1 and 3 mg/kg -RRB- , did not inhibit responses to tilt .
2145423	7	10-methyl-11-hydroxyaporphine	1170,1199	serotonin1A_receptor	1060,1080	10-methyl-11-hydroxyaporphine	serotonin1A receptor	MESH:C054813	24473(Tax:10116)	Chemical	Gene	PM-1000|dep|START_ENTITY END_ENTITY|conj|PM-1000	On the other hand , serotonin1A_receptor agonists , -LRB- 8-hydroxy-2-di-n-propylaminotetralin , 100 and 300 micrograms/kg -RRB- and PM-1000 -LRB- 10-methyl-11-hydroxyaporphine , 1 and 3 mg/kg -RRB- , did not inhibit responses to tilt .
1666334	1	10-methyl-11-hydroxyaporphine	151,180	Serotonin1A_receptor	77,97	10-methyl-11-hydroxyaporphine	Serotonin1A receptor	MESH:C054813	24473(Tax:10116)	Chemical	Gene	tetralin|conj|START_ENTITY -|amod|tetralin agonists|appos|- agonists|amod|END_ENTITY	Serotonin1A_receptor agonists , 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin and 10-methyl-11-hydroxyaporphine , inhibited electrical stimulation-induced contraction of the guinea-pig ileum .
9066300	0	10-methyl-13-demethyl	104,125	rhodopsin	145,154	10-methyl-13-demethyl	rhodopsin	null	509933(Tax:9913)	Chemical	Gene	retinal|amod|START_ENTITY retinal|acl|containing containing|dobj|END_ENTITY	Steric hindrance between chromophore substituents as the driving force of rhodopsin photoisomerization : 10-methyl-13-demethyl retinal containing rhodopsin .
9066300	0	10-methyl-13-demethyl	104,125	rhodopsin	74,83	10-methyl-13-demethyl	rhodopsin	null	509933(Tax:9913)	Chemical	Gene	retinal|amod|START_ENTITY hindrance|dep|retinal hindrance|nmod|substituents substituents|nmod|force force|nmod|photoisomerization photoisomerization|compound|END_ENTITY	Steric hindrance between chromophore substituents as the driving force of rhodopsin photoisomerization : 10-methyl-13-demethyl retinal containing rhodopsin .
9066300	1	10-methyl-13-demethyl	187,208	rhodopsin	278,287	10-methyl-13-demethyl	rhodopsin	null	509933(Tax:9913)	Chemical	Gene	retinal|amod|START_ENTITY analogue|appos|retinal synthesized|nsubjpass|analogue synthesized|nmod|END_ENTITY	A visual chromophore analogue , 10-methyl-13-demethyl -LRB- dm -RRB- retinal , was synthesized and reconstituted with bleached bovine rhodopsin to form a visual pigment derivative with absorbance maximum at 505 nm .
24677503	8	10-methyl-aplog-1	1189,1206	ATX	1266,1269	10-methyl-aplog-1	ATX	null	140477(Tax:10090)	Chemical	Gene	START_ENTITY|appos|analog analog|nmod|aplysiatoxin aplysiatoxin|appos|END_ENTITY	We have recently identified 10-methyl-aplog-1 -LRB- 26 -RRB- , a simplified analog of tumor-promoting aplysiatoxin -LRB- ATX -RRB- , as a possible therapeutic lead for cancer .
24744020	7	10-methyl_C17	664,677	C17	648,651	10-methyl C17	C17	null	54360	Chemical	Gene	0|nummod|START_ENTITY 8c|conj|0 fatty_acids|dep|8c fatty_acids|dep|0 0|appos|END_ENTITY	The major fatty_acids were iso-C16 : 0 , C17 : 1 8c and 10-methyl_C17 : 0 .
23178730	6	10-methyl_C18	1067,1080	C18	1041,1044	10-methyl C18	C18	null	27241	Chemical	Gene	0|appos|START_ENTITY 9c|dep|0 END_ENTITY|dep|9c	The major cellular fatty_acids were C18 : 1 9c , iso-C15 : 0 , 10-methyl_C18 : 0 -LRB- tuberculostearic_acid -RRB- , C16 : 0 , C18 : 0 and iso-C16 : 0 .
27381319	8	10-methyl_C18	756,769	C18	739,742	10-methyl C18	C18	null	27241	Chemical	Gene	9c|appos|START_ENTITY fatty_acids|dep|9c fatty_acids|dep|0 0|appos|END_ENTITY	The major fatty_acids were iso-C16 : 0 , C18 : 1 9c , 10-methyl_C18 : 0 and anteiso-C17 : 0 .
27902232	7	10-methyl_C18	962,975	C18	945,948	10-methyl C18	C18	null	27241	Chemical	Gene	9c|appos|START_ENTITY END_ENTITY|dep|9c	The major fatty_acids -LRB- C18 : 1 9c , 10-methyl_C18 : 0 , C16 : 0 , C18 ___ : ___ 0 , _ C16 : 0 2-OH -RRB- were consistent with the fatty_acid patterns reported for members of the genus Aeromicrobium .
10833330	7	10-methylenetetrahydrofolate	1418,1446	folate_receptor-alpha	1509,1530	10-methylenetetrahydrofolate	folate receptor-alpha	null	2348	Chemical	Gene	reductase|amod|START_ENTITY alleles|conj|reductase alleles|conj|region region|nmod|gene gene|amod|END_ENTITY	The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene .
10833330	7	10-methylenetetrahydrofolate	1418,1446	FR-alpha	1532,1540	10-methylenetetrahydrofolate	FR-alpha	null	79874	Chemical	Gene	reductase|amod|START_ENTITY alleles|conj|reductase alleles|conj|region region|nmod|gene gene|appos|END_ENTITY	The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene .
10528242	1	10-methylenetetrahydrofolate	249,277	MTHFR	289,294	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY 5|appos|reductase 5|appos|END_ENTITY	A number of studies have demonstrated that the common polymorphism 677C -- > T in the gene encoding 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- leads to a thermolabile variant with decreased enzyme activity and to mildly elevated plasma homocysteine .
10600168	2	10-methylenetetrahydrofolate	287,315	MTHFR	251,256	10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	5-methyltetrahydrofolate|amod|START_ENTITY reduction|amod|5-methyltetrahydrofolate used|nsubj|reduction catalyzes|ccomp|used catalyzes|nsubj|END_ENTITY	MTHFR catalyzes the reduction of 5 , 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , used to methylate_homocysteine in methionine synthesis .
10833330	7	10-methylenetetrahydrofolate	1418,1446	MTHFR	1458,1463	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	The loci investigated included two known alleles of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene , as well as the promoter region of the folate_receptor-alpha -LRB- FR-alpha -RRB- gene .
15022402	0	10-methylenetetrahydrofolate	39,67	MTHFR	79,84	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	-LSB- Frequency of C677T polymorphism of 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- in Chilean mothers of spina_bifida cases and controls -RSB- .
17492607	4	10-methylenetetrahydrofolate	610,638	MTHFR	650,655	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Both plasma levels of homocysteine -LRB- Hc -RRB- and the mutation of the gene for 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- were determined .
20229089	2	10-methylenetetrahydrofolate	274,302	MTHFR	314,319	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY 5|appos|reductase 5|appos|END_ENTITY	The C677T polymorphism of the 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene has been postulated to be a genetic risk factor for venous_thromboembolism and osteonecrosis in Caucasians , but this relationship has not been established in other populations .
20863444	1	10-methylenetetrahydrofolate	156,184	MTHFR	196,201	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	OBJECTIVES : To determine whether 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- rs1801133C/T , rs1801131A/C , rs2274976A/G , rs2066462C/T genetic polymorphisms are associated with clinical response and adverse effects -LRB- AEs -RRB- of methotrexate -LRB- MTX -RRB- treatment in Chinese Han patients with rheumatoid_arthritis -LRB- RA -RRB- .
22540831	2	10-methylenetetrahydrofolate	253,281	MTHFR	293,298	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY show|dobj|reductase Studies|dep|show Studies|dep|END_ENTITY	Studies in Western populations show that 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- 677C > T and Factor V -LRB- F5 -RRB- 1691G > A -LRB- Leiden -RRB- polymorphisms are commonly associated with pre-eclampsia and recurrent spontaneous pregnancy_loss .
26717388	2	10-methylenetetrahydrofolate	435,463	MTHFR	475,480	10-methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	This study used the case-control method to investigate the association between plasma homocysteine and the C677T gene polymorphism of its key metabolic enzyme , 5 , 10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- , and early renal_damage in a hypertensive Chinese Han population.A total of 379 adult essential hypertensive patients were selected as the study subjects .
1626951	2	10-methylene_tetrahydrofolate	272,301	thymidylate_synthase	216,236	10-methylene tetrahydrofolate	thymidylate synthase	null	7298	Chemical	Gene	binds|xcomp|START_ENTITY binds|advmod|tightly tightly|nmod|END_ENTITY	FdUMP which is an active metabolite of 5-FU binds tightly to thymidylate_synthase in the presence of the cofactor 5 , 10-methylene_tetrahydrofolate .
15666596	1	10-Methylenetetrahydrofolate	114,142	MTHFR	154,159	10-Methylenetetrahydrofolate	MTHFR	null	4524	Chemical	Gene	Reductase|amod|START_ENTITY Reductase|appos|END_ENTITY	5 , _ 10-Methylenetetrahydrofolate Reductase -LRB- MTHFR -RRB- is one of the key enzymes in the metabolism of homocysteine , where it catalyses its remethylation .
27147217	6	10-methylene_tetrahydromethanopterin	1190,1226	bpss0686	1157,1165	10-methylene tetrahydromethanopterin	bpss0686	null	3095474(Tax:272560)	Chemical	Gene	reductase|amod|START_ENTITY encoding|dobj|reductase encoding|nmod|bprR bprR|conj|END_ENTITY	Inactivation of the entire BprRS TCSTS -LRB- bprRS double mutant -RRB- resulted in altered expression of only nine genes , including both bprR and bprS , five phage-related genes and bpss0686 , encoding a putative 5 , 10-methylene_tetrahydromethanopterin reductase involved in one carbon metabolism .
2002449	2	10-methyl_ether	584,599	COMT	462,466	10-methyl ether	COMT	null	1312	Chemical	Gene	using|nmod|START_ENTITY END_ENTITY|acl|using	In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine -LRB- 10,11-dihydroxyaporphine -RRB- is converted in high yield into its 10-methyl_ether , apocodeine .
7057422	8	10-methylfolic_acid	1155,1174	THF	1098,1101	10-methylfolic acid	THF	MESH:C008622	21831(Tax:10090)	Chemical	Gene	give|dobj|START_ENTITY alkylated|xcomp|give alkylated|advmod|END_ENTITY	Also , both folic_acid and 5 - -LRB- CHO -RRB- - THF were reductively alkylated with formaldehyde to give 10-methylfolic_acid -LRB- 6 -RRB- and 5 - -LRB- CHO -RRB- -10 - -LRB- CH3 -RRB- - THF -LRB- 28 -RRB- , respectively .
7057422	8	10-methylfolic_acid	1155,1174	THF	1200,1203	10-methylfolic acid	THF	MESH:C008622	21831(Tax:10090)	Chemical	Gene	give|dobj|START_ENTITY give|dep|-10 -10|dep|CH3 CH3|dep|END_ENTITY	Also , both folic_acid and 5 - -LRB- CHO -RRB- - THF were reductively alkylated with formaldehyde to give 10-methylfolic_acid -LRB- 6 -RRB- and 5 - -LRB- CHO -RRB- -10 - -LRB- CH3 -RRB- - THF -LRB- 28 -RRB- , respectively .
16411756	3	10-methylretinal	700,716	C10	670,673	10-methylretinal	C10	null	113246	Chemical	Gene	strongly|advcl|START_ENTITY C13|advmod|strongly C13|compound|END_ENTITY	After relaxation inside the protein , all chromophores show significant nonplanar distortions from C10 to C13 , most strongly for 10-methylretinal and least pronounced for 9-demethylretinal .
16411756	3	10-methylretinal	700,716	C13	677,680	10-methylretinal	C13	null	3229	Chemical	Gene	strongly|advcl|START_ENTITY END_ENTITY|advmod|strongly	After relaxation inside the protein , all chromophores show significant nonplanar distortions from C10 to C13 , most strongly for 10-methylretinal and least pronounced for 9-demethylretinal .
26860474	5	10-methyl_retinal	857,874	Rhodopsin	694,703	10-methyl retinal	Rhodopsin	null	6010	Chemical	Gene	stepwise|conj|START_ENTITY proceeds|xcomp|stepwise proceeds|nsubj|formation formation|compound|END_ENTITY	Rhodopsin formation proceeds stepwise with prolonged lifetimes especially for 9-demethyl_retinal -LRB- longest lifetime 3 = 7500 s , cf. , 3500 s for retinal -RRB- , and for 10-methyl_retinal -LRB- 3 = 7850 s -RRB- .
1504339	2	10-methyl-undecanoic_acid	432,457	RS1	549,552	10-methyl-undecanoic acid	RS1	null	6247	Chemical	Gene	A|dep|START_ENTITY assigned|nmod|A residues|acl|assigned confirm|dobj|residues confirm|conj|establish establish|dobj|residues residues|nmod|A1 A1|conj|END_ENTITY	The results confirm the residues previously assigned to Factor A -LRB- n-undecanoic acid -RRB- and B -LRB- 10-methyl-undecanoic_acid -RRB- and establish the residues of Factor A1 -LRB- 9-methyl-decanoic_acid -RRB- , B1 -LRB- n-dodecanoic_acid -RRB- , RS1 -LRB- 8-methyl-nonanoic_acid -RRB- , RS2 -LRB- n-decanoic_acid -RRB- , and RS3 _ -LRB- n-tridecanoic_acid -RRB- .
2523370	3	10-methylundecanoic_acid	478,502	RS-1	405,409	10-methylundecanoic acid	RS-1	null	6247	Chemical	Gene	chains|amod|START_ENTITY having|dobj|chains teicoplanins|acl|having teicoplanins|nsubj|Two Two|acl|named named|xcomp|END_ENTITY	Two of them , named RS-1 and RS-2 , were shown to be teicoplanins having as fatty_acid chains 10-methylundecanoic_acid and n-dodecanoic_acid , respectively .
26272165	2	10MeV	521,526	CaF2	580,584	10MeV	CaF2	null	9337	Chemical	Gene	power|conj|START_ENTITY MgF2|nmod|power MgF2|conj|END_ENTITY	The optimal moderator materials were found to be MgF2 for proton energies less than 10MeV because of lower required accelerator beam power and CaF2 for higher proton energies because of lower photon dose rate at the treatment position after neutron irradiation .
6262173	1	10-micromilligram_Dexamethasone	143,174	CNP	291,294	10-micromilligram Dexamethasone	CNP	null	1267	Chemical	Gene	START_ENTITY|ref|which cause|nsubj|which cause|dobj|differentiation differentiation|nmod|phosphohydrolase phosphohydrolase|appos|END_ENTITY	Cultures of glial cell lines -LRB- C6 -RRB- were exposed to 10-micromilligram_Dexamethasone which is known to cause morphological differentiation and induction of 2 ' ,3 ' - cyclic_nucleotide_3 ' - phosphohydrolase -LRB- CNP -RRB- in these cells .
2934548	8	10_mM-phosphate	1067,1082	ATPase	1096,1102	10 mM-phosphate	ATPase	null	1769	Chemical	Gene	affected|advcl|START_ENTITY affected|conj|activity activity|amod|END_ENTITY	The maximum contraction velocity of both fast and slow fibres was not affected by 10_mM-phosphate , nor was the ATPase activity of the slow fibres during isometric contraction .
12590612	5	10-N-acetamidodecyl_chloromethyl_ketone	621,660	cellular_retinol-binding_protein_I	673,707	10-N-acetamidodecyl chloromethyl ketone	cellular retinol-binding protein I	null	19659(Tax:10090)	Chemical	Gene	START_ENTITY|conj|END_ENTITY	Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol .
12590612	5	10-N-acetamidodecyl_chloromethyl_ketone	621,660	CRBP	709,713	10-N-acetamidodecyl chloromethyl ketone	CRBP	null	19659(Tax:10090)	Chemical	Gene	START_ENTITY|appos|END_ENTITY	Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol .
12590612	5	10-N-acetamidodecyl_chloromethyl_ketone	621,660	lecithin_retinol_acyltransferase	576,608	10-N-acetamidodecyl chloromethyl ketone	lecithin retinol acyltransferase	null	79235(Tax:10090)	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol .
12590612	5	10-N-acetamidodecyl_chloromethyl_ketone	621,660	LRAT	610,614	10-N-acetamidodecyl chloromethyl ketone	LRAT	null	79235(Tax:10090)	Chemical	Gene	lecithin_retinol_acyltransferase|nmod|START_ENTITY lecithin_retinol_acyltransferase|appos|END_ENTITY	Inhibition of lecithin_retinol_acyltransferase -LRB- LRAT -RRB- with 10-N-acetamidodecyl_chloromethyl_ketone -LRB- AcDCMK -RRB- or cellular_retinol-binding_protein_I -LRB- CRBP -RRB- diminished the generation of both retinyl_esters and 11-cis retinol from all-trans retinol .
4186	0	10-N-acylaminophenothiazine	21,48	SAS	10,13	10-N-acylaminophenothiazine	SAS	null	362890(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of SAS -LRB- a new 10-N-acylaminophenothiazine -RRB- on gastric secretion and ulceration in rats .
23937156	10	10-NCP	1149,1155	Drp1	1245,1249	10-NCP	Drp1	null	10059	Chemical	Gene	able|nsubj|START_ENTITY able|ccomp|increase increase|xcomp|verifying verifying|dobj|result result|nmod|depletion depletion|amod|END_ENTITY	Further , 10-NCP was able increase average mitochondrial size and length verifying a functional result of Drp1 depletion in these neurons .
12372420	0	10-nitro-folate	110,125	folate_receptor_beta	129,149	10-nitro-folate	folate receptor beta	MESH:C468779	2350	Chemical	Gene	binding|nmod|START_ENTITY peroxynitrite|conj|binding folic_acid|nmod|peroxynitrite folic_acid|nmod|END_ENTITY	Nitration and chlorination of folic_acid by peroxynitrite and hypochlorous_acid , and the selective binding of 10-nitro-folate to folate_receptor_beta .
12372420	6	10-nitro-folate	822,837	FR-beta	870,877	10-nitro-folate	FR-beta	MESH:C468779	2350	Chemical	Gene	showed|nsubj|START_ENTITY showed|nmod|END_ENTITY	The 10-nitro-folate showed the selective binding to FR-beta , compared to folic_acid .
2586490	5	10-nitrogen	1113,1124	FPGS	1246,1250	10-nitrogen	FPGS	null	14287(Tax:10090)	Chemical	Gene	substituents|nmod|START_ENTITY analogs|nmod|substituents series|nmod|analogs studied|nsubjpass|series found|advcl|studied found|xcomp|diminish diminish|nmod|substrates substrates|nmod|END_ENTITY	When a homologous series of 5,8-dideazafolic _ acid analogs with hydrocarbon substituents on the 10-nitrogen were studied , these substituents were found to diminish the efficiency of utilization of these analogs as substrates for FPGS ; this effect increased with increasing chain length of the hydrocarbon .
16272718	3	10-nitro-goniothalamin	427,449	vp-16	636,641	10-nitro-goniothalamin	vp-16	null	3054	Chemical	Gene	derivatives|amod|START_ENTITY gave|nsubj|derivatives gave|advcl|microg/ml microg/ml|nsubj|that that|nmod|etoposide etoposide|dep|END_ENTITY	The derivatives 10-nitro-goniothalamin and 10-amino-goniothalamin gave selective inhibition concentration -LRB- IC50 -RRB- of 1.10 and 1.14 microg/ml , respectively , against human stomach_cancer SGC-7901 cells , while that of etoposide -LRB- vp-16 -RRB- as the positive control was 6.07 microg/ml .
20593759	0	10-nitrolinoleic_acid	53,74	PPAR-gamma	34,44	10-nitrolinoleic acid	PPAR-gamma	null	5468	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|agonist agonist|amod|END_ENTITY	Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic_acid .
20593759	1	10-nitrolinoleic_acid	160,181	PPAR-gamma	100,110	10-nitrolinoleic acid	PPAR-gamma	null	5468	Chemical	Gene	dienoic_acid|dep|START_ENTITY prepared|nsubjpass|dienoic_acid ligand|conj|prepared ligand|nsubj|END_ENTITY	The naturally occurring PPAR-gamma ligand 10-nitrooctadeca-9 -LRB- E -RRB- ,12 -LRB- Z -RRB- - dienoic_acid -LRB- 10-nitrolinoleic_acid -RRB- -LRB- 2a -RRB- was prepared as a single regio - and geometrical isomer in a practical eight-step , convergent sequence .
26598510	4	10-nitro-octadec-9-enoic_acid	672,701	AngII	632,637	10-nitro-octadec-9-enoic acid	AngII	null	11606(Tax:10090)	Chemical	Gene	angiotensin_II|dep|START_ENTITY angiotensin_II|appos|END_ENTITY	METHODS AND RESULTS : Wild-type C57BL6/J mice were treated for 2 weeks with angiotensin_II -LRB- AngII -RRB- and vehicle or nitro-oleic_acid -LRB- 10-nitro-octadec-9-enoic_acid , OA-NO2 , 6 mg/kg body weight -RRB- via subcutaneous osmotic minipumps .
26598510	4	10-nitro-octadec-9-enoic_acid	672,701	angiotensin_II	616,630	10-nitro-octadec-9-enoic acid	angiotensin II	null	11606(Tax:10090)	Chemical	Gene	END_ENTITY|dep|START_ENTITY	METHODS AND RESULTS : Wild-type C57BL6/J mice were treated for 2 weeks with angiotensin_II -LRB- AngII -RRB- and vehicle or nitro-oleic_acid -LRB- 10-nitro-octadec-9-enoic_acid , OA-NO2 , 6 mg/kg body weight -RRB- via subcutaneous osmotic minipumps .
21357422	3	10-nitro-octadec-9-enoic_acid	604,633	Keap1	769,774	10-nitro-octadec-9-enoic acid	Keap1	MESH:C069772	9817	Chemical	Gene	-|conj|START_ENTITY activate|nsubj|- activate|advcl|focusing focusing|nmod|modifications modifications|nmod|cysteines cysteines|nmod|END_ENTITY	In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses .
21357422	3	10-nitro-octadec-9-enoic_acid	604,633	Nrf2	679,683	10-nitro-octadec-9-enoic acid	Nrf2	MESH:C069772	4780	Chemical	Gene	-|conj|START_ENTITY activate|nsubj|- activate|dobj|END_ENTITY	In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses .
21357422	3	10-nitro-octadec-9-enoic_acid	604,633	Nrf2	754,758	10-nitro-octadec-9-enoic acid	Nrf2	MESH:C069772	4780	Chemical	Gene	-|conj|START_ENTITY activate|nsubj|- activate|advcl|focusing focusing|nmod|modifications modifications|nmod|cysteines cysteines|nmod|Keap1 Keap1|amod|END_ENTITY	In this study , we investigate the molecular mechanisms by which 9 - and 10-nitro-octadec-9-enoic_acid -LRB- OA-NO -LRB- 2 -RRB- -RRB- activate the transcription factor Nrf2 , focusing on the post-translational modifications of cysteines in the Nrf2 inhibitor Keap1 by nitroalkylation and its downstream responses .
21252222	6	10-nitrooleate	1084,1098	ALDH-2	1134,1140	10-nitrooleate	ALDH-2	null	217	Chemical	Gene	prostaglandin_J|conj|START_ENTITY 4-Hydroxynonenal|appos|prostaglandin_J caused|nsubj|4-Hydroxynonenal caused|dobj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	4-Hydroxynonenal , an oxidized prostaglandin_J -LRB- 2 -RRB- , and 9 - or 10-nitrooleate caused a significant inhibition of ALDH-2 activity , which was improved in the presence of Mg -LRB- 2 + -RRB- and Ca -LRB- 2 + -RRB- .
28739872	8	10-nitro-oleic_acid	1331,1350	MKK3	1482,1486	10-nitro-oleic acid	MKK3	MESH:C521487	303200(Tax:10116)	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|advcl|obstructing obstructing|dobj|access access|compound|END_ENTITY	In contrast , the anti-inflammatory agent 10-nitro-oleic_acid -LRB- NO2-OA -RRB- , a component of the Mediterranean diet , reduced p38a activation and covalently modified Cys119/Cys162 , likely obstructing MKK3 access .
24368768	6	10-nitro-oleic_acid	1297,1316	PPARy	1318,1323	10-nitro-oleic acid	PPARy	MESH:C521487	5468	Chemical	Gene	synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|nsubj|agonists agonists|compound|END_ENTITY	Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB .
24368768	6	10-nitro-oleic_acid	1297,1316	PPARy	1355,1360	10-nitro-oleic acid	PPARy	MESH:C521487	5468	Chemical	Gene	synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|dobj|expression expression|amod|END_ENTITY	Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB .
24368768	6	10-nitro-oleic_acid	1297,1316	PPARy	1581,1586	10-nitro-oleic acid	PPARy	MESH:C521487	5468	Chemical	Gene	synthetic|dep|START_ENTITY Treating|nmod|synthetic up-regulated|dep|Treating up-regulated|conj|reversed reversed|dep|inhibiting inhibiting|conj|promoting promoting|dobj|inhibitory inhibitory|nmod|END_ENTITY	Treating epithelial cells with synthetic -LRB- rosiglitazone -RRB- or endogenous -LRB- 10-nitro-oleic_acid -RRB- PPARy agonists strongly up-regulated PPARy expression and activity , suppressed CSE-induced production and secretion of inflammatory cytokines , and reversed its activation of NF-kB by inhibiting the IkB kinase pathway and by promoting direct inhibitory binding of PPARy to NF-kB .
6898427	1	10-nitro-so-trans-anti-cys-perhydroacridine	220,263	MT-2	265,269	10-nitro-so-trans-anti-cys-perhydroacridine	MT-2	null	17750(Tax:10090)	Chemical	Gene	START_ENTITY|appos|END_ENTITY	Chemotherapeutic activity of various benzylpenicillin combinations with 10-nitro-so-trans-anti-cys-perhydroacridine -LRB- MT-2 -RRB- was studied on 2 experimental staphylococcal_infections caused by pathogenic penicillin resistant strains of staphylococci .
7119643	5	10nM-domperidone	646,662	prolactin	665,674	10nM-domperidone	prolactin	null	24683(Tax:10116)	Chemical	Gene	treated|advcl|START_ENTITY began|advcl|treated began|nsubj|secretion secretion|compound|END_ENTITY	When glands were treated with 10nM-domperidone , prolactin secretion began to decline after the first hour , reaching a maximum of 40-50 % inhibition after a further 90 min .
27285083	4	10-NMe2	688,695	NMe2	620,624	10-NMe2	NMe2	null	4831	Chemical	Gene	group|amod|START_ENTITY consists|nmod|group consists|nsubj|specifics specifics|nmod|/ /|amod|END_ENTITY	At the same time , unexpected specifics of the protonated NMe2 / - N = systems consists in a strong shift of the NH proton to the 10-NMe2 group contrary to the `` aniline-pyridine '' basicity rule .
27113852	2	10nM_estradiol	518,532	fshb	406,410	10nM estradiol	fshb	null	402919(Tax:7955)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|levels levels|amod|END_ENTITY	In our present study , we first observed that fshb and lhb mRNA levels in the pituitary of male adult zebrafish were greatly inhibited by 3 weeks exposure to 10nM_estradiol -LRB- E2 -RRB- .
27113852	2	10nM_estradiol	518,532	lhb	415,418	10nM estradiol	lhb	null	402917(Tax:7955)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|levels levels|amod|fshb fshb|conj|END_ENTITY	In our present study , we first observed that fshb and lhb mRNA levels in the pituitary of male adult zebrafish were greatly inhibited by 3 weeks exposure to 10nM_estradiol -LRB- E2 -RRB- .
15107464	7	10-N-nonyl_acridine	1167,1186	Bid	1225,1228	10-N-nonyl acridine	Bid	null	637	Chemical	Gene	orange|amod|START_ENTITY dye|appos|orange suppress|nsubj|dye suppress|xcomp|binding binding|nsubj|END_ENTITY	Like the binding to the mitochondria , this interaction could not be blocked by the mutation in the BH3 domain or by Bcl-x -LRB- L. -RRB- However , a cardiolipin-specific dye , 10-N-nonyl_acridine orange , could preferentially suppress Bid binding to the mitochondrial contact site and inhibit Bid-induced mitochondrial cristae reorganization and cytochrome_c release .
15107464	7	10-N-nonyl_acridine	1167,1186	cytochrome_c	1336,1348	10-N-nonyl acridine	cytochrome c	null	54205	Chemical	Gene	orange|amod|START_ENTITY dye|appos|orange suppress|nsubj|dye suppress|conj|inhibit inhibit|dobj|reorganization reorganization|conj|release release|amod|END_ENTITY	Like the binding to the mitochondria , this interaction could not be blocked by the mutation in the BH3 domain or by Bcl-x -LRB- L. -RRB- However , a cardiolipin-specific dye , 10-N-nonyl_acridine orange , could preferentially suppress Bid binding to the mitochondrial contact site and inhibit Bid-induced mitochondrial cristae reorganization and cytochrome_c release .
17682315	6	10-N-nonyl_acridine_orange	931,957	annexin_V	866,875	10-N-nonyl acridine orange	annexin V	null	25673(Tax:10116)	Chemical	Gene	fluorescence|nmod|START_ENTITY loss|nmod|fluorescence staining|conj|loss staining|amod|END_ENTITY	Apoptosis was measured by annexin_V and propidium_iodide staining , loss of fluorescence of 10-N-nonyl_acridine_orange -LRB- NAO -RRB- , a cardiolipin specific fluorescent dye , and cleavage of pro-caspase-9 by western blot analysis .
22009280	4	10-N-nonyl_acridine_orange	612,638	LIF	688,691	10-N-nonyl acridine orange	LIF	null	3976	Chemical	Gene	interaction|amod|START_ENTITY based|nmod|interaction based|nmod|cardiolipin cardiolipin|acl|using using|dobj|CE CE|nmod|detection detection|compound|END_ENTITY	The method presented is based on the online 10-N-nonyl_acridine_orange -LRB- NAO -RRB- interaction with cardiolipin using CE with LIF detection .
23211592	4	10-N-nonyl-acridine_orange	469,495	p21	431,434	10-N-nonyl-acridine orange	p21	null	1026	Chemical	Gene	staining|amod|START_ENTITY measured|nmod|staining cells|dep|measured cells|amod|END_ENTITY	We found that there was a significant increase in the mitochondrial mass of p21 -LRB- - / - -RRB- HCT116 cells , as measured by 10-N-nonyl-acridine_orange staining , as well as an increase in the mitochondrial DNA content .
24140437	9	10-NO	1387,1392	caveolin-1	1424,1434	10-NO	caveolin-1	null	12389(Tax:10090)	Chemical	Gene	9-NO|conj|START_ENTITY upregulated|nsubj|9-NO upregulated|dobj|expression expression|nmod|END_ENTITY	9-NO and 10-NO also upregulated expression of caveolin-1 , the major structural component of caveolae .
24650615	7	10-nonadecenoic_acid_methyl_ester	729,762	FAME	620,624	10-nonadecenoic acid methyl ester	FAME	null	554188	Chemical	Gene	palmitic_acid_methyl_ester|conj|START_ENTITY palmitic_acid_methyl_ester|nsubj|END_ENTITY	The major FAME contained in the biodiesel were palmitic_acid_methyl_ester -LRB- C16 :0 -RRB- , oleic_acid methyl ester -LRB- C18 :1 -RRB- and 10-nonadecenoic_acid_methyl_ester -LRB- C19 :1 -RRB- .
24773391	0	10-nornaltrexones	25,42	Toll-like_receptor_4	61,81	10-nornaltrexones	Toll-like receptor 4	null	7099	Chemical	Gene	START_ENTITY|nmod|search search|nmod|antagonists antagonists|compound|END_ENTITY	Synthesis of enantiopure 10-nornaltrexones in the search for Toll-like_receptor_4 antagonists and opioid ligands .
3951252	1	1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine	170,219	ALP	221,224	1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine	ALP	null	470	Chemical	Gene	START_ENTITY|appos|END_ENTITY	A panel of 16 human hematopoietic cell lines was tested for sensitivity to racemic 1-0-octadecyl-2-0-methyl-glycero-3-phosphocholine -LRB- ALP -RRB- .
7849275	3	1-0-octadecyl_2-0-methylglycero_phosphocholine	805,851	phospholipase_A2	861,877	1-0-octadecyl 2-0-methylglycero phosphocholine	phospholipase A2	MESH:C076164	29526(Tax:10116)	Chemical	Gene	di-O-hexadecylglycerophosphocholine|conj|START_ENTITY lowered|nsubj|di-O-hexadecylglycerophosphocholine lowered|dobj|activity activity|amod|END_ENTITY	When introduced into the culture medium at 1 , 5 or 10 microM , the membrane phospholipid analogue 1,2 di-O-hexadecylglycerophosphocholine -LRB- dihexadecyl-GPC -RRB- , but not the lysolecithin analogue 1-0-octadecyl_2-0-methylglycero_phosphocholine , lowered phospholipase_A2 activity with either labelling method .
2308973	6	1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine	886,939	ALP	941,944	1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine	ALP	null	11691(Tax:10090)	Chemical	Gene	START_ENTITY|appos|END_ENTITY	Lethally irradiated Balb/c mice were injected with normal bone marrow cells containing 1-2 % leukemic cells -LRB- WEHI III-B -RRB- to simulate a remission marrow after the cells were incubated in vitro for 24 hours with 0-100 ug/ml of 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine -LRB- ALP -RRB- .
3775692	1	1-0-octadecyl_Paf-acether	248,273	thrombin	138,146	1-0-octadecyl Paf-acether	thrombin	null	100009146(Tax:9986)	Chemical	Gene	1-0-hexadecyl_Paf-acether|conj|START_ENTITY Collagen|amod|1-0-hexadecyl_Paf-acether Collagen|appos|END_ENTITY	Collagen -LRB- 10-40 micrograms kg-1 -RRB- , thrombin -LRB- 1-10 units kg-1 -RRB- , adenosine_diphosphate -LRB- ADP ; 3-300 micrograms kg-1 -RRB- , 1-0-hexadecyl_Paf-acether and 1-0-octadecyl_Paf-acether -LRB- 1-300 ng kg-1 -RRB- administered by bolus intravenous injection each caused dose-dependent thrombocytopoenia accompanied by marked hypotension in anaesthetized rabbits .
11411558	3	10-O-demethylemetine	796,816	CYP2D6	662,668	10-O-demethylemetine	CYP2D6	null	1565	Chemical	Gene	emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing able|conj|participated able|nsubj|CYP3A4 CYP3A4|conj|END_ENTITY	CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine .
11411558	3	10-O-demethylemetine	796,816	CYP3A4	651,657	10-O-demethylemetine	CYP3A4	null	1576	Chemical	Gene	emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing able|conj|participated able|nsubj|END_ENTITY	CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine .
11411558	3	10-O-demethylemetine	796,816	CYP3A4	744,750	10-O-demethylemetine	CYP3A4	null	1576	Chemical	Gene	emetine|advcl|START_ENTITY metabolizing|xcomp|emetine participated|advcl|metabolizing participated|nsubj|END_ENTITY	CYP3A4 and CYP2D6 were able to metabolize emetine to cephaeline and 9-O-demethylemetine , and CYP3A4 also participated in metabolizing emetine to 10-O-demethylemetine .
17009856	1	10-OH	123,128	EGFR	219,223	10-OH	EGFR	null	1956	Chemical	Gene	camptothecin|appos|START_ENTITY act|nsubj|camptothecin act|nmod|inhibitor inhibitor|appos|END_ENTITY	The chemotherapeutic agent camptothecin , 10-OH -LRB- CPT,10-OH -RRB- , was shown to act synergistically with the epithelial_growth_factor_receptor -LRB- EGFR -RRB- inhibitor -LRB- AG1478 -RRB- against several transformed cell lines .
17009856	1	10-OH	123,128	epithelial_growth_factor_receptor	184,217	10-OH	epithelial growth factor receptor	null	1956	Chemical	Gene	camptothecin|appos|START_ENTITY act|nsubj|camptothecin act|nmod|inhibitor inhibitor|compound|END_ENTITY	The chemotherapeutic agent camptothecin , 10-OH -LRB- CPT,10-OH -RRB- , was shown to act synergistically with the epithelial_growth_factor_receptor -LRB- EGFR -RRB- inhibitor -LRB- AG1478 -RRB- against several transformed cell lines .
16190932	13	10-OHCBZ	2157,2165	MDR1	2123,2127	10-OHCBZ	MDR1	null	5243	Chemical	Gene	concentration|nummod|START_ENTITY correlated|nmod|concentration correlated|nsubjpass|level level|nmod|expression expression|nmod|END_ENTITY	The level of expression of MDR1 is inversely correlated with 10-OHCBZ concentration in the epileptic tissue .
16190932	2	10-OHCBZ	572,580	MDR1	551,555	10-OHCBZ	MDR1	null	5243	Chemical	Gene	levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|P-glycoprotein P-glycoprotein|dep|P-gp P-gp|conj|END_ENTITY	We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens .
16190932	2	10-OHCBZ	572,580	MDR1	713,717	10-OHCBZ	MDR1	null	5243	Chemical	Gene	levels|nummod|START_ENTITY determining|dobj|levels determining|advcl|measuring measuring|ccomp|substrate substrate|conj|relation relation|nmod|level level|nmod|expression expression|nmod|END_ENTITY	We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens .
16190932	8	10-OHCBZ	1565,1573	MDR1	1647,1651	10-OHCBZ	MDR1	null	5243	Chemical	Gene	ratio|nummod|START_ENTITY ratio|conj|level level|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	A significant inverse linear correlation was found between 10-OHCBZ brain-to-plasma concentration ratio and the level of brain expression of MDR1 mRNA .
16190932	2	10-OHCBZ	572,580	P-glycoprotein	527,541	10-OHCBZ	P-glycoprotein	null	5243	Chemical	Gene	levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|END_ENTITY	We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens .
16190932	12	10-OHCBZ	1981,1989	P-gp	2090,2094	10-OHCBZ	P-gp	null	283871	Chemical	Gene	appear|nsubj|START_ENTITY appear|conj|acts acts|nmod|substrate substrate|nmod|END_ENTITY	10-OHCBZ does not appear to cross the blood-brain barrier by simple diffusion , and it acts as a substrate of P-gp .
16190932	2	10-OHCBZ	572,580	P-gp	543,547	10-OHCBZ	P-gp	null	283871	Chemical	Gene	levels|nummod|START_ENTITY determining|dobj|levels addressed|advcl|determining addressed|dobj|contribution contribution|nmod|P-glycoprotein P-glycoprotein|dep|END_ENTITY	We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens .
16190932	2	10-OHCBZ	572,580	P-gp	656,660	10-OHCBZ	P-gp	null	283871	Chemical	Gene	levels|nummod|START_ENTITY determining|dobj|levels determining|advcl|measuring measuring|ccomp|substrate substrate|nmod|END_ENTITY	We addressed the possible contribution of the multidrug transporter P-glycoprotein -LRB- P-gp or MDR1 -RRB- in determining 10-OHCBZ brain levels by measuring whether this active metabolite is a substrate of P-gp and the relation between the level of expression of MDR1 and the drug concentration in the same brain tissue specimens .
16190932	5	10-OHCBZ	1133,1141	P-gp	1164,1168	10-OHCBZ	P-gp	null	283871	Chemical	Gene	ability|nmod|START_ENTITY ability|acl|act act|nmod|substate substate|nmod|END_ENTITY	The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor .
16190932	5	10-OHCBZ	1133,1141	P-gp	1252,1256	10-OHCBZ	P-gp	null	283871	Chemical	Gene	ability|nmod|START_ENTITY evaluated|nsubjpass|ability evaluated|advcl|measuring measuring|nmod|lines lines|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY	The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor .
16190932	5	10-OHCBZ	1133,1141	P-gp	1300,1304	10-OHCBZ	P-gp	null	283871	Chemical	Gene	ability|nmod|START_ENTITY evaluated|nsubjpass|ability evaluated|advcl|measuring measuring|nmod|lines lines|acl|expressing expressing|nmod|presence presence|nmod|inhibitor inhibitor|compound|END_ENTITY	The ability of 10-OHCBZ to act as substate of P-gp was evaluated by measuring its uptake in cell lines expressing different levels of P-gp , in the presence or absence of a selective P-gp inhibitor .
16190932	9	10-OHCBZ	1715,1723	P-gp	1752,1756	10-OHCBZ	P-gp	null	283871	Chemical	Gene	levels|nummod|START_ENTITY levels|nmod|cells cells|nmod|expression expression|compound|END_ENTITY	In vitro uptake studies demonstrated lower intracellular 10-OHCBZ levels in cells with higher P-gp expression .
16132345	15	10-OH-CPT	3010,3019	CPT-11	2980,2986	10-OH-CPT	CPT-11	MESH:C106646	963084(Tax:115711)	Chemical	Gene	CPT|conj|START_ENTITY CPT|amod|END_ENTITY	CONCLUSIONS : Human MRP4 rendered significant resistance to cyclophosphamide , CPT , CPT-11 , SN-38 , rubitecan , and 10-OH-CPT .
16132345	4	10-OH-CPT	804,813	CPT-11	758,764	10-OH-CPT	CPT-11	MESH:C106646	963084(Tax:115711)	Chemical	Gene	CPT|appos|START_ENTITY CPT|conj|END_ENTITY	In this study , we explored the resistance profiles and intracellular accumulation of a panel of CPTs including CPT , CPT-11 , SN-38 , rubitecan , and 10-hydroxy-CPT -LRB- 10-OH-CPT -RRB- in HepG2 cells with stably overexpressed human MRP4 .
16132345	15	10-OH-CPT	3010,3019	MRP4	2917,2921	10-OH-CPT	MRP4	MESH:C106646	10257	Chemical	Gene	CPT|conj|START_ENTITY rendered|dobj|CPT rendered|nsubj|END_ENTITY	CONCLUSIONS : Human MRP4 rendered significant resistance to cyclophosphamide , CPT , CPT-11 , SN-38 , rubitecan , and 10-OH-CPT .
16132345	4	10-OH-CPT	804,813	MRP4	862,866	10-OH-CPT	MRP4	MESH:C106646	10257	Chemical	Gene	CPT|appos|START_ENTITY CPT|dep|END_ENTITY	In this study , we explored the resistance profiles and intracellular accumulation of a panel of CPTs including CPT , CPT-11 , SN-38 , rubitecan , and 10-hydroxy-CPT -LRB- 10-OH-CPT -RRB- in HepG2 cells with stably overexpressed human MRP4 .
18643284	3	10OHF	460,465	C11	471,474	10OHF	C11	null	51728	Chemical	Gene	mixtures|nmod|START_ENTITY mixtures|nmod|END_ENTITY	Binary mixtures of 10OHF with C11 , a compound with the typical phase sequence among the smectic phases , show that the unusual phase sequence of 10OHF stabilizes upon mixing and that SmC * FI2 predominates over SmC * throughout the entire mixing phase diagram .
18643284	3	10OHF	585,590	C11	471,474	10OHF	C11	null	51728	Chemical	Gene	sequence|nmod|START_ENTITY stabilizes|nsubj|sequence show|ccomp|stabilizes show|nsubj|mixtures mixtures|nmod|END_ENTITY	Binary mixtures of 10OHF with C11 , a compound with the typical phase sequence among the smectic phases , show that the unusual phase sequence of 10OHF stabilizes upon mixing and that SmC * FI2 predominates over SmC * throughout the entire mixing phase diagram .
26567730	4	10-OH-NBP	864,873	P-gp	734,738	10-OH-NBP	P-gp	null	287115(Tax:10116)	Chemical	Gene	3-OH-NBP|conj|START_ENTITY received|dobj|3-OH-NBP received|parataxis|pretreated pretreated|nmod|tariquidar tariquidar|compound|END_ENTITY	To evaluate the influences of major efflux transporters , rats were pretreated with the P-gp inhibitor tariquidar -LRB- 10 mg/kg , iv -RRB- and BCRP inhibitor pantoprazole -LRB- 40 mg/kg , iv -RRB- , then received 3-OH-NBP -LRB- 12 mg/kg , iv -RRB- or 10-OH-NBP -LRB- 3 mg/kg , iv -RRB- .
8867869	1	10-OH-NT	267,275	CYP2D6	141,147	10-OH-NT	CYP2D6	null	1565	Chemical	Gene	10-hydroxynortriptyline|appos|START_ENTITY nortriptyline|conj|10-hydroxynortriptyline levels|nmod|nortriptyline relationship|conj|levels relationship|nmod|genotype genotype|compound|END_ENTITY	The relationship between the CYP2D6 genotype and the steady state plasma levels of nortriptyline -LRB- NT -RRB- , its main active metabolite 10-hydroxynortriptyline -LRB- 10-OH-NT -RRB- and the NT/10-OH-NT ratio were studied in 21 Caucasian depressed patients treated with 100-150 mg NT daily .
9358338	5	10-OHODA	751,759	CO2	922,925	10-OHODA	CO2	null	717	Chemical	Gene	presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|conj|extracted extracted|nsubjpass|END_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
9358338	5	10-OHODA	936,944	CO2	922,925	10-OHODA	CO2	null	717	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
9358338	5	10-OHODA	751,759	phospholipase_A2	1035,1051	10-OHODA	phospholipase A2	null	5319	Chemical	Gene	presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|conj|extracted extracted|nmod|macrophages macrophages|nmod|diethylether diethylether|nmod|treatment treatment|amod|END_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
9358338	5	10-OHODA	936,944	phospholipase_A2	1035,1051	10-OHODA	phospholipase A2	null	5319	Chemical	Gene	CO2|nmod|START_ENTITY extracted|nsubjpass|CO2 extracted|nmod|macrophages macrophages|nmod|diethylether diethylether|nmod|treatment treatment|amod|END_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
9358338	5	10-OHODA	751,759	THP-1	831,836	10-OHODA	THP-1	null	2736	Chemical	Gene	presence|nmod|START_ENTITY demonstrate|dobj|presence exposed|advcl|demonstrate exposed|nsubjpass|macrophages macrophages|acl|derived derived|nmod|END_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
9358338	5	10-OHODA	936,944	THP-1	831,836	10-OHODA	THP-1	null	2736	Chemical	Gene	CO2|nmod|START_ENTITY extracted|nsubjpass|CO2 exposed|conj|extracted exposed|nsubjpass|macrophages macrophages|acl|derived derived|nmod|END_ENTITY	In order to demonstrate the presence of 10-OHODA in living cells , macrophages derived from the human leukemia cell line THP-1 by adding 160nM phorbol_12-myristate_13-acetate -LRB- PMA -RRB- were exposed to 95 % O2 , and 5 % CO2 for 24 h. 10-OHODA and other fatty_acids were extracted from the exposed macrophages with diethylether after phospholipase_A2 treatment .
26305953	10	10-OPEA	1807,1814	cystatin-9	1959,1969	10-OPEA	cystatin-9	null	732826(Tax:4577)	Chemical	Gene	application|nummod|START_ENTITY promotes|nsubj|application promotes|dobj|activation activation|acl:relcl|inhibited inhibited|nmod|overexpression overexpression|nmod|inhibitor inhibitor|amod|END_ENTITY	Consistent with a role in dying tissue , 10-OPEA application promotes cysteine protease activation and cell death , which is inhibited by overexpression of the cysteine protease inhibitor maize cystatin-9 .
6421328	1	10-O-p-toluenesulfonyldecane-1-O-phosphocholine	142,189	phospholipase_A2	87,103	10-O-p-toluenesulfonyldecane-1-O-phosphocholine	phospholipase A2	MESH:D013481	29526(Tax:10116)	Chemical	Gene	reacting|xcomp|START_ENTITY prepared|advcl|reacting prepared|nsubjpass|adsorbent adsorbent|nmod|END_ENTITY	An affinity adsorbent for phospholipase_A2 -LRB- EC 3.1.1.4 -RRB- was prepared by reacting 10-O-p-toluenesulfonyldecane-1-O-phosphocholine with AH-Sepharose_4B .
12743168	2	10-O-succinoylryanodol	447,469	RyR	489,492	10-O-succinoylryanodol	RyR	MESH:C481699	6261	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	As is the case for all ryanoids so far examined , the interaction of 10-O-succinoylryanodol with an individual RyR channel produces profound alterations in both channel gating and rates of ion translocation .
12743168	4	10-O-succinoylryanodol	887,909	RyR	864,867	10-O-succinoylryanodol	RyR	MESH:C481699	6261	Chemical	Gene	presence|nmod|START_ENTITY observe|nmod|presence observe|dobj|range range|nmod|states states|nmod|END_ENTITY	Unlike the majority of ryanoids , we observe a range of different fractional conductance states of RyR in the presence of 10-O-succinoylryanodol .
12743168	5	10-O-succinoylryanodol	931,953	RyR	1119,1122	10-O-succinoylryanodol	RyR	MESH:C481699	6261	Chemical	Gene	molecule|nsubj|START_ENTITY demonstrate|ccomp|molecule demonstrate|conj|propose propose|ccomp|arises arises|nmod|interaction interaction|nmod|conformer conformer|nmod|molecule molecule|nmod|channel channel|compound|END_ENTITY	We demonstrate that 10-O-succinoylryanodol is a very flexible molecule and propose that each fractional conductance state arises from the interaction of a different conformer of the ryanoid molecule with the RyR channel .
6838824	1	10-oxide	253,261	glutathione_S-transferase	119,144	10-oxide	glutathione S-transferase	null	58962(Tax:10116)	Chemical	Gene	catalyze|xcomp|START_ENTITY catalyze|nsubj|Three Three|nmod|isozymes isozymes|nmod|END_ENTITY	Three of the isozymes of glutathione_S-transferase -LRB- EC 2.5.1.18 -RRB- from rat liver -LRB- isozymes A , B , and C -RRB- catalyze the addition of glutathione to phenanthrene 9 , 10-oxide with varying degrees of efficiency and stereoselectivity .
3558412	0	10-oxirane	44,54	P-450	35,40	10-oxirane	P-450	null	1555	Chemical	Gene	androgens|amod|START_ENTITY cytochrome|nmod|androgens cytochrome|dobj|END_ENTITY	Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens .
3558412	6	10-oxirane	1093,1103	P-450arom	987,996	10-oxirane	P-450arom	null	1588	Chemical	Gene	nm|dep|START_ENTITY shifts|nmod|nm showed|ccomp|shifts showed|nsubj|titrations titrations|nmod|preparations preparations|conj|END_ENTITY	Spectral titrations of microsomal preparations and purified P-450arom showed that binding of the 19R-isomers shifts the Soret maximum of the ferric enzyme to 411 nm -LRB- 10-oxirane -RRB- or 425 nm -LRB- 10-thiirane -RRB- ; addition of excess androstenedione reversed the spectral changes , producing the high spin form of the enzyme with a Soret peak at 393 nm .
27392685	2	10-oxo	466,472	to_1_and_2	437,447	10-oxo	to 1 and 2	null	109748(Tax:10090)	Chemical	Gene	moieties|amod|START_ENTITY important|nsubj|moieties suggests|ccomp|important suggests|nsubj|END_ENTITY	Bioassay results of various compounds related to_1_and_2 suggests that the 10-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity .
2831435	1	10-oxo-19-nor-vitamin_D3	125,149	25-OH-10-oxo-D3	208,223	10-oxo-19-nor-vitamin D3	25-OH-10-oxo-D3	null	1735	Chemical	Gene	START_ENTITY|conj|5 5|amod|25-hydroxy-10-oxo-19-nor-vitamin_D3 25-hydroxy-10-oxo-19-nor-vitamin_D3|dep|END_ENTITY	Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively .
2831435	1	10-oxo-19-nor-vitamin_D3	125,149	D3	263,265	10-oxo-19-nor-vitamin D3	D3	null	1735	Chemical	Gene	START_ENTITY|dep|products products|nmod|vitamin_D3 vitamin_D3|appos|END_ENTITY	Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively .
18447385	0	10-oxocembranoids	35,52	C-3	2,5	10-oxocembranoids	C-3	null	718	Chemical	Gene	isocembranoid|conj|START_ENTITY methylated|xcomp|isocembranoid methylated|nsubj|END_ENTITY	A C-3 methylated isocembranoid and 10-oxocembranoids from a formosan soft coral , Sinularia grandilobata .
18447385	2	10-oxocembranoids	399,416	C-3	343,346	10-oxocembranoids	C-3	null	718	Chemical	Gene	identified|nmod|START_ENTITY have|advcl|identified have|nmod|group group|nmod|cembranoid cembranoid|acl|rearranged rearranged|nmod|END_ENTITY	Grandilobatin_C -LRB- 3 -RRB- was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3 , while the other metabolites were identified as new 10-oxocembranoids .
18447385	2	10-oxocembranoids	399,416	C-4	287,290	10-oxocembranoids	C-4	null	720	Chemical	Gene	identified|nmod|START_ENTITY have|advcl|identified have|nmod|group group|compound|END_ENTITY	Grandilobatin_C -LRB- 3 -RRB- was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3 , while the other metabolites were identified as new 10-oxocembranoids .
2831435	1	10-oxo-D3	151,160	25-OH-10-oxo-D3	208,223	10-oxo-D3	25-OH-10-oxo-D3	null	1735	Chemical	Gene	10-oxo-19-nor-vitamin_D3|dep|START_ENTITY 10-oxo-19-nor-vitamin_D3|conj|5 5|amod|25-hydroxy-10-oxo-19-nor-vitamin_D3 25-hydroxy-10-oxo-19-nor-vitamin_D3|dep|END_ENTITY	Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively .
2831435	5	10-oxo-D3	597,606	25-OH-10-oxo-D3	611,626	10-oxo-D3	25-OH-10-oxo-D3	null	1735	Chemical	Gene	START_ENTITY|conj|END_ENTITY	In addition , both 10-oxo-D3 and 25-OH-10-oxo-D3 showed poor affinities for either the plasma D3-binding protein or the thymus 1,25-dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- receptor .
2831435	1	10-oxo-D3	151,160	D3	263,265	10-oxo-D3	D3	null	1735	Chemical	Gene	10-oxo-19-nor-vitamin_D3|dep|START_ENTITY 10-oxo-19-nor-vitamin_D3|dep|products products|nmod|vitamin_D3 vitamin_D3|appos|END_ENTITY	Biological assays were performed to evaluate 10-oxo-19-nor-vitamin_D3 -LRB- 10-oxo-D3 -RRB- and 5 -LRB- E -RRB- 25-hydroxy-10-oxo-19-nor-vitamin_D3 -LRB- 25-OH-10-oxo-D3 -RRB- two bacterial products of vitamin_D3 -LRB- D3 -RRB- and 25-hydroxyvitamin_D3 -LRB- 25-OHD3 -RRB- metabolism , respectively .
2831435	2	10-oxo-D3	357,366	D3	420,422	10-oxo-D3	D3	null	1735	Chemical	Gene	isomers|advcl|START_ENTITY 5|amod|isomers 40|nsubj|5 40|conj|80-fold 80-fold|amod|active active|nmod|END_ENTITY	The 5 -LRB- Z -RRB- and 5 -LRB- E -RRB- isomers of 10-oxo-D3 were , respectively , 40 - and 80-fold less active than D3 in stimulating Ca +2 absorption from the gut .
2831435	5	10-oxo-D3	597,606	D3	727,729	10-oxo-D3	D3	null	1735	Chemical	Gene	showed|nsubj|START_ENTITY showed|nmod|protein protein|conj|receptor receptor|compound|END_ENTITY	In addition , both 10-oxo-D3 and 25-OH-10-oxo-D3 showed poor affinities for either the plasma D3-binding protein or the thymus 1,25-dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- receptor .
25883	2	10-oxooctadecanoate	387,406	B3266	122,127	10-oxooctadecanoate	B3266	null	947768(Tax:511145)	Chemical	Gene	production|nmod|START_ENTITY catalyzed|dobj|production dehydrogenase|acl:relcl|catalyzed induction|conj|dehydrogenase resulted|nmod|induction resulted|nsubj|END_ENTITY	NRRL B3266 in the presence of oleic_acid resulted in the induction of two enzymes : oleate hydratase , which produced 10 -LRB- R -RRB- hydroxyoctadecanoate , and hydroxyoctadecanoate dehydrogenase , which catalyzed the oxidized nicotinamide_adenine_dinucleotide-dependent production of 10-oxooctadecanoate .
18780387	3	10-oxo-PEA	717,727	LeAOS3	633,639	10-oxo-PEA	LeAOS3	null	101247264	Chemical	Gene	cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid|dep|START_ENTITY alpha-ketol|conj|cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid became|nsubj|alpha-ketol performed|advcl|became performed|nmod|amounts amounts|nmod|END_ENTITY	In contrast , the relative yield of 9,10-EOD progressively decreased when the incubations were performed with fourfold , tenfold , or 80-fold larger amounts of LeAOS3 , while alpha-ketol and the cyclopentenone_rac-cis-10-oxo-11-phytoenoic_acid -LRB- 10-oxo-PEA -RRB- became the predominant products .
18780387	4	10-oxo-PEA	787,797	LeAOS3	822,828	10-oxo-PEA	LeAOS3	null	101247264	Chemical	Gene	alpha-ketol|conj|START_ENTITY produced|nsubjpass|alpha-ketol produced|advcl|exposed exposed|nsubjpass|END_ENTITY	Both the alpha-ketol and 10-oxo-PEA were also produced when LeAOS3 was exposed to preformed 9,10-EOD , which was generated by maize allene_oxide synthase -LRB- CYP74A -RRB- .
27816594	2	10-perylene_tetracarboxylic_acid	340,372	AAT	457,460	10-perylene tetracarboxylic acid	AAT	null	5265	Chemical	Gene	nanotubes|amod|START_ENTITY 3|conj|nanotubes 3|dep|silver silver|compound|END_ENTITY	The biosensor was composed of 3 , 4 , 9 , 10-perylene_tetracarboxylic_acid / carbon nanotubes -LRB- PTCA-CNTs -RRB- as a sensing platform and alkaline phosphatase-labeled AAT antibody functionalized silver nanoparticles -LRB- ALP-AAT Ab-Ag NPs -RRB- as a signal enhancer .
15297453	6	10-phenylbiliverdin_IXalpha	821,848	hHO-1	710,715	10-phenylbiliverdin IXalpha	hHO-1	MESH:C032608	3162	Chemical	Gene	give|xcomp|START_ENTITY position|acl|give 15-phenylheme|nmod|position 15-phenylheme|dep|cleaves cleaves|amod|END_ENTITY	We report here that hHO-1 cleaves 5-phenylheme to biliverdin_IXalpha and oxidizes 15-phenylheme at the alpha-meso position to give 10-phenylbiliverdin_IXalpha .
23606933	4	10-propargyl_10-deazaaminopterin	615,647	folylpolyglutamate_synthetase	774,803	10-propargyl 10-deazaaminopterin	folylpolyglutamate synthetase	MESH:C418863	2356	Chemical	Gene	Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|conj|END_ENTITY	Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- .
23606933	4	10-propargyl_10-deazaaminopterin	615,647	FPGS	805,809	10-propargyl 10-deazaaminopterin	FPGS	MESH:C418863	2356	Chemical	Gene	Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|appos|END_ENTITY	Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- .
23606933	4	10-propargyl_10-deazaaminopterin	615,647	reduced_folate_receptor	736,759	10-propargyl 10-deazaaminopterin	reduced folate receptor	MESH:C418863	6573	Chemical	Gene	Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|END_ENTITY	Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- .
23606933	4	10-propargyl_10-deazaaminopterin	615,647	RFC	761,764	10-propargyl 10-deazaaminopterin	RFC	MESH:C418863	6573	Chemical	Gene	Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|ref|that have|nsubj|that have|dobj|affinity affinity|nmod|reduced_folate_receptor reduced_folate_receptor|appos|END_ENTITY	Pralatrexate -LRB- 10-propargyl_10-deazaaminopterin -RRB- is a unique antifolate that has been rationally designed to have high affinity for the reduced_folate_receptor -LRB- RFC -RRB- and the folylpolyglutamate_synthetase -LRB- FPGS -RRB- and was the first drug ever approved for the treatment of relapsed and refractory peripheral T-cell_lymphomas -LRB- PTCL -RRB- .
20501616	1	10-propargyl-10-deazaaminopterin	156,188	RFC-1	307,312	10-propargyl-10-deazaaminopterin	RFC-1	MESH:C418863	5981	Chemical	Gene	Pralatrexate|dep|START_ENTITY antifolate|nsubj|Pralatrexate antifolate|nmod|uptake uptake|conj|retention retention|amod|due due|nmod|affinity affinity|nmod|carrier carrier|appos|END_ENTITY	PURPOSE : Pralatrexate -LRB- 10-propargyl-10-deazaaminopterin -RRB- is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier -LRB- RFC-1 -RRB- and folyl-polyglutamyl synthase .
8600835	10	10-pyrenedecanoic_acid	1944,1966	sPLA2	1899,1904	10-pyrenedecanoic acid	sPLA2	null	5320	Chemical	Gene	trap|nmod|START_ENTITY provide|dobj|trap composed|conj|provide composed|nmod|excess excess|nmod|vesicles vesicles|acl:relcl|bind bind|dobj|END_ENTITY	The latter is composed of phosphatidylcholine vesicles , in excess of substrate vesicles , which do not bind sPLA2 but provide a trap for enzyme-produced 10-pyrenedecanoic_acid .
21054397	2	10-pyrene_phosphatidylcholine	374,403	PLA	278,281	10-pyrene phosphatidylcholine	PLA	null	27281(Tax:10090)	Chemical	Gene	arachidonyl_phosphatidylcholine|conj|START_ENTITY C|amod|arachidonyl_phosphatidylcholine activity|dep|C activity|compound|END_ENTITY	METHODS : We measured arachidonic_acid release in -LSB- H -RSB- arachidonic_acid-labelled Raw 264.7 cells and PLA activity using 1-palmitoyl-2 - -LSB- _____ C -RSB- arachidonyl_phosphatidylcholine -LRB- -LSB- C -RSB- AA-PC -RRB- and 10-pyrene_phosphatidylcholine in vitro .
9142863	11	10-pyrene_phosphatidylcholine	1467,1496	PLA2	1385,1389	10-pyrene phosphatidylcholine	PLA2	MESH:C033518	5319	Chemical	Gene	signal|nmod|START_ENTITY slope|nmod|signal reflected|nmod|slope increased|advcl|reflected increased|dobj|activity activity|compound|END_ENTITY	Ca/CaM also increased PLA2 activity , as reflected by an increase in the slope of fluorescence signal of 10-pyrene_phosphatidylcholine , a substrate for PLA2 .
9142863	11	10-pyrene_phosphatidylcholine	1467,1496	PLA2	1514,1518	10-pyrene phosphatidylcholine	PLA2	MESH:C033518	5319	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Ca/CaM also increased PLA2 activity , as reflected by an increase in the slope of fluorescence signal of 10-pyrene_phosphatidylcholine , a substrate for PLA2 .
2742139	1	10-pyrenyldecanoic_acid	289,312	Phospholipase_A2	136,152	10-pyrenyldecanoic acid	Phospholipase A2	MESH:C052091	5319	Chemical	Gene	position|nmod|START_ENTITY labeled|nmod|position phospholipids|acl|labeled using|dobj|phospholipids determined|xcomp|using determined|nsubjpass|activity activity|amod|END_ENTITY	Phospholipase_A2 activity can be determined fluorometrically in the presence of serum_albumin using phospholipids labeled at the sn-2-acyl position with 10-pyrenyldecanoic_acid .
2742139	1	10-pyrenyldecanoic_acid	289,312	serum_albumin	216,229	10-pyrenyldecanoic acid	serum albumin	MESH:C052091	213	Chemical	Gene	position|nmod|START_ENTITY labeled|nmod|position phospholipids|acl|labeled using|dobj|phospholipids determined|xcomp|using determined|nmod|presence presence|nmod|END_ENTITY	Phospholipase_A2 activity can be determined fluorometrically in the presence of serum_albumin using phospholipids labeled at the sn-2-acyl position with 10-pyrenyldecanoic_acid .
9443042	0	10q22-23	84,92	PTEN	156,160	10q22-23	PTEN	MESH:D064532	5728	Chemical	Gene	locus|advcl|START_ENTITY imbalance|amod|locus imbalance|nmod|Cowden_syndrome Cowden_syndrome|conj|mutation mutation|compound|END_ENTITY	Allelic imbalance , including deletion of PTEN/MMACI , at the Cowden_disease locus on 10q22-23 , in hamartomas from patients with Cowden_syndrome and germline PTEN mutation .
26300167	1	10R-germacradienyl	700,718	C-10	685,689	10R-germacradienyl	C-10	null	3226	Chemical	Gene	cation|amod|START_ENTITY form|dobj|cation FPP|acl|form FPP|nmod|si-face si-face|nmod|END_ENTITY	The absolute configurations of kelsoene and prespatane thus determined suggest that initial cyclization of FPP from the si-face at C-10 to form a 10R-germacradienyl cation leads to kelsoene , while that from the re-face leads to prespatane via the 10S-germacradienyl cation .
6181401	0	10S	28,31	acetylcholinesterase	32,52	10S	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Reduced axonal transport of 10S acetylcholinesterase in dystrophic mice .
16424216	6	10S,17S-diHDHA	1308,1322	PD1	1427,1430	10S,17S-diHDHA	PD1	null	6139	Chemical	Gene	carried|nsubj|START_ENTITY carried|advcl|proceeded proceeded|nsubj|formation formation|compound|END_ENTITY	18O2 labeling showed that 10S,17S-diHDHA -LRB- isomer I -RRB- carried 18O in the carbon-10 position alcohol , indicating sequential lipoxygenation , whereas PD1 formation proceeded via an epoxide .
16424216	9	10S,17S-diHDHA	1819,1833	PD1	1762,1765	10S,17S-diHDHA	PD1	null	6139	Chemical	Gene	Delta15-trans-PD1|amod|START_ENTITY END_ENTITY|dobj|Delta15-trans-PD1	The rank order at 1 - to 10-ng dose was PD1 approximately PD1_methyl_ester > Delta15-trans-PD1 > 10S,17S-diHDHA -LRB- isomer I -RRB- .
26300167	1	10S-germacradienyl	801,819	C-10	685,689	10S-germacradienyl	C-10	null	3226	Chemical	Gene	cation|amod|START_ENTITY prespatane|nmod|cation leads|xcomp|prespatane leads|advcl|leads leads|nsubj|cyclization cyclization|nmod|FPP FPP|nmod|si-face si-face|nmod|END_ENTITY	The absolute configurations of kelsoene and prespatane thus determined suggest that initial cyclization of FPP from the si-face at C-10 to form a 10R-germacradienyl cation leads to kelsoene , while that from the re-face leads to prespatane via the 10S-germacradienyl cation .
20837112	2	10-shogaol	363,373	COX-2	307,312	10-shogaol	COX-2	MESH:C585130	4513	Chemical	Gene	bound|conj|START_ENTITY roots|conj|bound roots|nmod|ligands ligands|compound|END_ENTITY	Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands , and 10-gingerol , 12-gingerol , 8-shogaol , 10-shogaol , 6-gingerdione , 8-gingerdione , 10-gingerdione , 6-dehydro-10-gingerol , 6-paradol , and 8-paradol bound to the enzyme active site .
28872603	9	10-shogaol	1208,1218	GST	1298,1301	10-shogaol	GST	MESH:C585130	373156	Chemical	Gene	6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|MRP1 MRP1|conj|END_ENTITY	Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression .
28872603	9	10-shogaol	1208,1218	MRP1	1289,1293	10-shogaol	MRP1	MESH:C585130	4363	Chemical	Gene	6-gingerol|conj|START_ENTITY inhibit|csubj|6-gingerol inhibit|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Our results showed that 6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol inhibit the proliferation of PC3R cells through the downregulation of MRP1 and GST protein expression .
28872603	6	10-shogaol	770,780	PC3	934,937	10-shogaol	PC3	MESH:C585130	5122	Chemical	Gene	10-gingerol|conj|START_ENTITY M|amod|10-gingerol inhibited|nsubj|M inhibited|ccomp|displayed displayed|nmod|END_ENTITY	6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 .
28872603	6	10-shogaol	893,903	PC3	934,937	10-shogaol	PC3	MESH:C585130	5122	Chemical	Gene	PC3R|conj|START_ENTITY proliferation|acl|PC3R displayed|nsubj|proliferation displayed|nmod|END_ENTITY	6-gingerol , 10-gingerol , 6-shogaol , and 10-shogaol at the concentration of 100 M significantly inhibited the proliferation in PC3R but 6-gingerol , 6-shogaol , and 10-shogaol displayed similar activity in PC3 .
22408422	3	10-Shogaol	410,420	TGF-b	488,493	10-Shogaol	TGF-b	null	7040	Chemical	Gene	production|amod|START_ENTITY production|nmod|transforming_growth_factor-b transforming_growth_factor-b|appos|END_ENTITY	10-Shogaol enhanced growth factor production in transforming_growth_factor-b -LRB- TGF-b -RRB- , platelet derived growth factor-ab -LRB- PDGF-ab -RRB- and vascular endothelial growth factors -LRB- VEGF -RRB- of both cells .
22408422	3	10-Shogaol	410,420	transforming_growth_factor-b	458,486	10-Shogaol	transforming growth factor-b	null	7040	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	10-Shogaol enhanced growth factor production in transforming_growth_factor-b -LRB- TGF-b -RRB- , platelet derived growth factor-ab -LRB- PDGF-ab -RRB- and vascular endothelial growth factors -LRB- VEGF -RRB- of both cells .
16905316	1	10S-hydroxylobel-7-ene	505,527	DAT	584,587	10S-hydroxylobel-7-ene	DAT	null	6531	Chemical	Gene	3c|amod|START_ENTITY 8R-hydroxylobel-9-ene|conj|3c exhibited|nsubj|8R-hydroxylobel-9-ene exhibited|nmod|SERT SERT|conj|END_ENTITY	The enantiomers 8R-hydroxylobel-9-ene -LRB- 3a -RRB- and 10S-hydroxylobel-7-ene -LRB- 3c -RRB- exhibited high potency and selectivity at SERT and DAT , respectively .
16905316	1	10S-hydroxylobel-7-ene	505,527	SERT	575,579	10S-hydroxylobel-7-ene	SERT	null	6532	Chemical	Gene	3c|amod|START_ENTITY 8R-hydroxylobel-9-ene|conj|3c exhibited|nsubj|8R-hydroxylobel-9-ene exhibited|nmod|END_ENTITY	The enantiomers 8R-hydroxylobel-9-ene -LRB- 3a -RRB- and 10S-hydroxylobel-7-ene -LRB- 3c -RRB- exhibited high potency and selectivity at SERT and DAT , respectively .
27255290	0	10-substituted-2-morpholino-chromen-oxazine-dione	109,158	DNA-PK	34,40	10-substituted-2-morpholino-chromen-oxazine-dione	DNA-PK	null	5591	Chemical	Gene	Synthesis|conj|START_ENTITY Synthesis|conj|activity activity|compound|END_ENTITY	Synthesis , structure elucidation , DNA-PK , PI3K , anti-platelet and anti-bacteria activity of linear 5 , 6 , and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3 , _ 4 , _ 6-substituted-8-morpholino-chromen-oxazine-2 ,10 - dione .
27255290	0	10-substituted-2-morpholino-chromen-oxazine-dione	109,158	PI3K	42,46	10-substituted-2-morpholino-chromen-oxazine-dione	PI3K	null	5293	Chemical	Gene	Synthesis|conj|START_ENTITY Synthesis|conj|activity activity|compound|DNA-PK DNA-PK|conj|END_ENTITY	Synthesis , structure elucidation , DNA-PK , PI3K , anti-platelet and anti-bacteria activity of linear 5 , 6 , and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3 , _ 4 , _ 6-substituted-8-morpholino-chromen-oxazine-2 ,10 - dione .
12808237	0	10-thiaisoalloxazines	43,64	C-5	89,92	10-thiaisoalloxazines	C-5	null	727	Chemical	Gene	activity|nmod|START_ENTITY Synthesis|conj|activity Synthesis|appos|analog analog|nmod|C-6 C-6|compound|END_ENTITY	Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines , a structural analog of C-5 and/or C-6 substituted pyrimidine_acyclonucleoside .
12808237	0	10-thiaisoalloxazines	43,64	C-6	100,103	10-thiaisoalloxazines	C-6	null	729	Chemical	Gene	activity|nmod|START_ENTITY Synthesis|conj|activity Synthesis|appos|analog analog|nmod|END_ENTITY	Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines , a structural analog of C-5 and/or C-6 substituted pyrimidine_acyclonucleoside .
3558412	0	10-thiirane	59,70	P-450	35,40	10-thiirane	P-450	null	1555	Chemical	Gene	10-oxirane|conj|START_ENTITY androgens|amod|10-oxirane cytochrome|nmod|androgens cytochrome|dobj|END_ENTITY	Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens .
3558412	6	10-thiirane	1116,1127	P-450arom	987,996	10-thiirane	P-450arom	null	1588	Chemical	Gene	nm|dep|START_ENTITY shifts|nmod|nm showed|ccomp|shifts showed|nsubj|titrations titrations|nmod|preparations preparations|conj|END_ENTITY	Spectral titrations of microsomal preparations and purified P-450arom showed that binding of the 19R-isomers shifts the Soret maximum of the ferric enzyme to 411 nm -LRB- 10-oxirane -RRB- or 425 nm -LRB- 10-thiirane -RRB- ; addition of excess androstenedione reversed the spectral changes , producing the high spin form of the enzyme with a Soret peak at 393 nm .
27902770	10	10-TPP	1644,1650	caspase_3	1704,1713	10-TPP	caspase 3	null	836	Chemical	Gene	2-DG|conj|START_ENTITY Relative|nmod|2-DG showed|ccomp|Relative showed|dobj|activation activation|amod|END_ENTITY	Relative to 2-DG or 10-TPP alone , 2-DG plus 10-TPP combination showed increased caspase_3 activation in MM cells with minimal toxicity to the normal hematopoietic progenitor cells .
27902770	10	10-TPP	1668,1674	caspase_3	1704,1713	10-TPP	caspase 3	null	836	Chemical	Gene	combination|nummod|START_ENTITY 2-DG|nmod|combination showed|nsubj|2-DG showed|dobj|activation activation|amod|END_ENTITY	Relative to 2-DG or 10-TPP alone , 2-DG plus 10-TPP combination showed increased caspase_3 activation in MM cells with minimal toxicity to the normal hematopoietic progenitor cells .
9916876	2	10-tridecyl_ether	327,344	PLP	266,269	10-tridecyl ether	PLP	MESH:C117129	24943(Tax:10116)	Chemical	Gene	solution|nmod|START_ENTITY water|conj|solution solubilized|nmod|water solubilized|nsubjpass|END_ENTITY	PLP was solubilized in water or in an aqueous solution of 1 % 10-tridecyl_ether -LRB- TDE -RRB- , a non-ionic detergent used in membrane protein research .
10423286	1	10-undecenoate/p-methylbenzoate	636,667	CSP-1	730,735	10-undecenoate/p-methylbenzoate	CSP-1	null	1827	Chemical	Gene	amylose|conj|START_ENTITY 10-undecenoate/3|nmod|amylose derivatives|nsubj|10-undecenoate/3 derivatives|nmod|END_ENTITY	The mixed 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of cellulose , _ 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of amylose and 10-undecenoate/p-methylbenzoate of cellulose were the starting polysaccharide derivatives for CSP-1 , CSP-2 , and CSP-3 , respectively .
10423286	1	10-undecenoate/p-methylbenzoate	636,667	CSP-2	737,742	10-undecenoate/p-methylbenzoate	CSP-2	null	10231	Chemical	Gene	amylose|conj|START_ENTITY 10-undecenoate/3|nmod|amylose derivatives|nsubj|10-undecenoate/3 derivatives|nmod|CSP-1 CSP-1|conj|END_ENTITY	The mixed 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of cellulose , _ 10-undecenoate/3 , _ 5-dimethylphenylcarbamate of amylose and 10-undecenoate/p-methylbenzoate of cellulose were the starting polysaccharide derivatives for CSP-1 , CSP-2 , and CSP-3 , respectively .
8337229	5	10-undecynoic_acid	981,999	CYP2E	821,826	10-undecynoic acid	CYP2E	MESH:C048289	25086(Tax:10116)	Chemical	Gene	effect|advcl|START_ENTITY effect|nsubj|inducer inducer|compound|END_ENTITY	The CYP2E inducer , isoniazid and the CYP2E inhibitor , diallyl_sulfide were virtually without effect , as was the CYP4A inducer , clofibrate , and the CYP4A inhibitor , 10-undecynoic_acid .
8337229	5	10-undecynoic_acid	981,999	CYP2E	854,859	10-undecynoic acid	CYP2E	MESH:C048289	25086(Tax:10116)	Chemical	Gene	effect|advcl|START_ENTITY effect|nsubj|inducer inducer|appos|isoniazid isoniazid|conj|inhibitor inhibitor|compound|END_ENTITY	The CYP2E inducer , isoniazid and the CYP2E inhibitor , diallyl_sulfide were virtually without effect , as was the CYP4A inducer , clofibrate , and the CYP4A inhibitor , 10-undecynoic_acid .
10453996	2	10-undecynoic_acid	455,473	cytochrome_P450_4A1	541,560	10-undecynoic acid	cytochrome P450 4A1	MESH:C048289	50549(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY administration|nmod|rats administration|appos|inhibitor inhibitor|nmod|reaction reaction|acl|catalyzed catalyzed|nmod|END_ENTITY	On the other hand , administration to rats of 10-undecynoic_acid , a specific inhibitor of omega-hydroxylation reaction catalyzed by cytochrome_P450_4A1 , inhibits the ethanolamine-specific phospholipid base exchange activity by 30 % .
8486647	6	10-undecynoic_acid	1206,1224	L-FABP	1009,1015	10-undecynoic acid	L-FABP	MESH:C048289	2168	Chemical	Gene	1-aminobenzotriazole|conj|START_ENTITY pretranslationally|advcl|1-aminobenzotriazole pretranslationally|nsubj|increases increases|nmod|beta-oxidation beta-oxidation|conj|END_ENTITY	The CF-mediated increases in peroxisomal beta-oxidation and L-FABP , but not P-450IVA1 , could be significantly inhibited pretranslationally by concurrent exposure of cultured hepatocytes to inactivators of cytochromes P-450 , such as 1-aminobenzotriazole and 10-undecynoic_acid .
10453996	0	10-Undecynoic_acid	0,18	cytochrome_P450_4A1	36,55	10-Undecynoic acid	cytochrome P450 4A1	MESH:C048289	50549(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	10-Undecynoic_acid , an inhibitor of cytochrome_P450_4A1 , inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes .
9470175	4	10-Undecynoic_acid	872,890	lipase	960,966	10-Undecynoic acid	lipase	MESH:C048289	26302740	Chemical	Gene	gave|nsubj|START_ENTITY gave|nmod|kind kind|nmod|END_ENTITY	10-Undecynoic_acid gave the highest conversion rate of esterification with each kind of lipase used .
15720395	1	110-124	317,324	phospholipase_A2	164,180	110-124	phospholipase A2	MESH:C448907	100347180(Tax:9986)	Chemical	Gene	residues|nummod|START_ENTITY C-terminus|appos|residues variable|nsubj|C-terminus shows|ccomp|variable shows|nsubj|Comparison Comparison|nmod|structures structures|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Comparison of the crystal structures of three Micropechis ikaheka phospholipase_A2 isoenzymes -LRB- MiPLA2 , MiPLA3 and MiPLA4 , which exhibit different levels of pharmacological effects -RRB- shows that their C-terminus -LRB- residues 110-124 -RRB- is the most variable .
9685376	4	1103-amino_acid	617,632	KIF1C	641,646	1103-amino acid	KIF1C	MESH:C000596773	16562(Tax:10090)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Like its homologues , the 1103-amino_acid protein KIF1C consists of an amino-terminal motor domain followed by a U104_domain and probably binds to target membranes through carboxyl-terminal sequences .
20515953	3	1-104_amino_acids	651,668	IGF-II	643,649	1-104 amino acids	IGF-II	null	3481	Chemical	Gene	END_ENTITY|dep|START_ENTITY	Using a Fab-displaying phage library and a biotinylated precursor form of IGF-II -LRB- 1-104_amino_acids -RRB- as a target , we isolated Fabs specific for the E-domain COOH-terminal extension form of IGF-II and for mature IGF-II .
20515953	3	1-104_amino_acids	651,668	IGF-II	780,786	1-104 amino acids	IGF-II	null	3481	Chemical	Gene	IGF-II|dep|START_ENTITY form|nmod|IGF-II library|conj|form Using|dobj|library isolated|advcl|Using isolated|nmod|form form|conj|END_ENTITY	Using a Fab-displaying phage library and a biotinylated precursor form of IGF-II -LRB- 1-104_amino_acids -RRB- as a target , we isolated Fabs specific for the E-domain COOH-terminal extension form of IGF-II and for mature IGF-II .
9346957	6	110-amino_acid	1166,1180	Shc	1079,1082	110-amino acid	Shc	MESH:C005842	6464	Chemical	Gene	extension|amod|START_ENTITY generating|dobj|extension resulted|xcomp|generating resulted|nsubj|cDNA cDNA|compound|END_ENTITY	Sequence alignment confirmed that the 66-kDa Shc cDNA resulted from alternative splicing of the primary Shc transcript generating a 110-amino_acid extension at the amino terminus .
9346957	6	110-amino_acid	1166,1180	Shc	1138,1141	110-amino acid	Shc	MESH:C005842	6464	Chemical	Gene	extension|amod|START_ENTITY generating|dobj|extension resulted|xcomp|generating resulted|nmod|splicing splicing|nmod|transcript transcript|compound|END_ENTITY	Sequence alignment confirmed that the 66-kDa Shc cDNA resulted from alternative splicing of the primary Shc transcript generating a 110-amino_acid extension at the amino terminus .
8083230	5	110-amino-acid	786,800	cPLA2	769,774	110-amino-acid	cPLA2	MESH:C005842	5321	Chemical	Gene	region|amod|START_ENTITY contains|dobj|region contains|nsubj|END_ENTITY	We noted that cPLA2 contains a 110-amino-acid region with sequence homology to phospholipase B -LRB- PLB -RRB- from Penicillium_notatum .
8083230	5	110-amino-acid	786,800	PLB	851,854	110-amino-acid	PLB	MESH:C005842	5350	Chemical	Gene	region|amod|START_ENTITY contains|dobj|region contains|advcl|phospholipase phospholipase|dobj|END_ENTITY	We noted that cPLA2 contains a 110-amino-acid region with sequence homology to phospholipase B -LRB- PLB -RRB- from Penicillium_notatum .
11829755	10	110-amino-acid	1466,1480	Scamper	1453,1460	110-amino-acid	Scamper	MESH:C005842	286756	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	In contrast with what has been believed hitherto , our primary-structure and overexpression experiments indicate that Scamper is a 110-amino-acid protein spanning the membrane once with a Nexo/Ccyt topology -LSB- von_Heijne and Gavel -LRB- 1988 -RRB- Eur .
26405039	5	1,10-bisquinuclidinedecane	1284,1310	OCT1	1206,1210	1,10-bisquinuclidinedecane	OCT1	null	6580	Chemical	Gene	1,10-diaminodecane|conj|START_ENTITY polyamines|dep|1,10-diaminodecane polyamines|conj|blockers blockers|compound|END_ENTITY	Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s .
26405039	5	1,10-bisquinuclidinedecane	1284,1310	OCT3	1327,1331	1,10-bisquinuclidinedecane	OCT3	null	100049579	Chemical	Gene	1,10-diaminodecane|conj|START_ENTITY polyamines|dep|1,10-diaminodecane interactions|nmod|polyamines interactions|nmod|END_ENTITY	Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s .
16087391	8	1,10-DAC	1658,1666	CYP	1624,1627	1,10-DAC	CYP	null	4051	Chemical	Gene	mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|advcl|using using|nmod|cells cells|acl|expressing expressing|dobj|isoforms isoforms|compound|END_ENTITY	However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC .
16087391	8	1,10-DAC	1658,1666	CYP1A2	1705,1711	1,10-DAC	CYP1A2	null	1544	Chemical	Gene	mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|nmod|END_ENTITY	However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC .
16087391	9	1,10-DAC	1831,1839	CYP1A2	1886,1892	1,10-DAC	CYP1A2	null	1544	Chemical	Gene	shows|nsubj|START_ENTITY shows|nmod|involvement involvement|nmod|END_ENTITY	These results suggest that 1,10-DAC shows the mutagenicity through involvement of CYP1A2 in human liver , and 4,10-DAC does so through both CYP2A6 and 1A2 .
16087391	8	1,10-DAC	1658,1666	CYP2A6	1744,1750	1,10-DAC	CYP2A6	null	1548	Chemical	Gene	mutagenicity|nmod|START_ENTITY induced|nsubjpass|mutagenicity induced|advcl|contributed contributed|nsubj|END_ENTITY	However , in Ames tests using microsomes from insect cells expressing various human CYP isoforms , the mutagenicity of 1,10-DAC was induced only by recombinant human CYP1A2 , whereas both recombinant human CYP2A6 and 1A2 contributed to the mutagenicity of 4,10-DAC .
16087391	9	1,10-DAC	1831,1839	CYP2A6	1943,1949	1,10-DAC	CYP2A6	null	1548	Chemical	Gene	shows|nsubj|START_ENTITY suggest|ccomp|shows suggest|conj|does does|nmod|END_ENTITY	These results suggest that 1,10-DAC shows the mutagenicity through involvement of CYP1A2 in human liver , and 4,10-DAC does so through both CYP2A6 and 1A2 .
15664816	4	1,10-decylene-bis-sulfamate	860,887	hCA_IX	789,795	1,10-decylene-bis-sulfamate	hCA IX	MESH:D001729	768	Chemical	Gene	1,8-octylene-bis-sulfamate|conj|START_ENTITY detected|nmod|1,8-octylene-bis-sulfamate detected|nsubjpass|inhibitors inhibitors|compound|END_ENTITY	Several low nanomolar hCA_IX inhibitors were detected , such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate -LRB- K -LRB- I -RRB- s in the range of 4-7 nM -RRB- , which showed good selectivity ratios -LRB- in the range of 3.50-3 .85 -RRB- for hCA_IX over hCA II inhibition .
15664816	4	1,10-decylene-bis-sulfamate	860,887	hCA_IX	990,996	1,10-decylene-bis-sulfamate	hCA IX	MESH:D001729	768	Chemical	Gene	1,8-octylene-bis-sulfamate|conj|START_ENTITY 1,8-octylene-bis-sulfamate|acl:relcl|showed showed|dobj|ratios ratios|nmod|END_ENTITY	Several low nanomolar hCA_IX inhibitors were detected , such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate -LRB- K -LRB- I -RRB- s in the range of 4-7 nM -RRB- , which showed good selectivity ratios -LRB- in the range of 3.50-3 .85 -RRB- for hCA_IX over hCA II inhibition .
25612558	5	1,10-diaminodecane	1107,1125	alcohol_dehydrogenase	1042,1063	1,10-diaminodecane	alcohol dehydrogenase	MESH:C065351	10327	Chemical	Gene	rate|amod|START_ENTITY improved|dobj|rate matched|conj|improved matched|dobj|dehydrogenase dehydrogenase|amod|END_ENTITY	At 42 C , TaCv was more active , which matched thermostable alcohol_dehydrogenase and alanine dehydrogenase and improved the 1,10-diaminodecane production rate four-fold .
26512870	1	1,10-diaminodecane	501,519	III	577,580	1,10-diaminodecane	III	MESH:C065351	4514	Chemical	Gene	reaction|acl|START_ENTITY gave|nsubj|reaction gave|dobj|complex complex|appos|END_ENTITY	The amide formation reaction of with 1,10-diaminodecane and polyallylamine gave the diamine-bridged dinuclear Rh -LRB- III -RRB- complex and the single-chain polymer-supported Rh -LRB- III -RRB- complex with retention of the L configuration of , respectively .
26405039	5	1,10-diaminodecane	1221,1239	OCT1	1206,1210	1,10-diaminodecane	OCT1	MESH:C065351	6580	Chemical	Gene	polyamines|dep|START_ENTITY polyamines|conj|blockers blockers|compound|END_ENTITY	Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s .
26405039	5	1,10-diaminodecane	1221,1239	OCT3	1327,1331	1,10-diaminodecane	OCT3	MESH:C065351	100049579	Chemical	Gene	polyamines|dep|START_ENTITY interactions|nmod|polyamines interactions|nmod|END_ENTITY	Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bistriethylaminodecane , and 1,10-bisquinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s .
20961817	3	1-10-nucleotide	593,608	Pol_b	572,577	1-10-nucleotide	Pol b	MESH:D009711	5423	Chemical	Gene	gaps|amod|START_ENTITY filled|dobj|gaps determined|advcl|filled determined|parataxis|proposed proposed|xcomp|support support|dobj|polymerase_b polymerase_b|appos|END_ENTITY	Here , we quantitatively determined the substrate specificity and base substitution fidelity of human DNA polymerase -LRB- Pol -RRB- , an enzyme proposed to support the known BER DNA polymerase_b -LRB- Pol_b -RRB- , as it filled 1-10-nucleotide gaps at 1-nucleotide intervals .
20961817	3	1-10-nucleotide	593,608	polymerase_b	558,570	1-10-nucleotide	polymerase b	MESH:D009711	5423	Chemical	Gene	gaps|amod|START_ENTITY filled|dobj|gaps determined|advcl|filled determined|parataxis|proposed proposed|xcomp|support support|dobj|END_ENTITY	Here , we quantitatively determined the substrate specificity and base substitution fidelity of human DNA polymerase -LRB- Pol -RRB- , an enzyme proposed to support the known BER DNA polymerase_b -LRB- Pol_b -RRB- , as it filled 1-10-nucleotide gaps at 1-nucleotide intervals .
3314587	2	1,10-o-phenanthroline	465,486	Fibrinogen	321,331	1,10-o-phenanthroline	Fibrinogen	null	2244	Chemical	Gene	denaturation|nmod|START_ENTITY proteolysis|conj|denaturation sensitive|dep|proteolysis sensitive|nsubj|END_ENTITY	Fibrinogen is sensitive both to proteolysis by contaminants which may constitute as little as 0.2 % of the enzyme protein and to denaturation by 1,10-o-phenanthroline , the only substance known to inhibit the proteolysis .
7575672	8	1,10-O-phenanthroline	1407,1428	Aminopeptidase	1311,1325	1,10-O-phenanthroline	Aminopeptidase	null	10404	Chemical	Gene	amastatin|conj|START_ENTITY inhibited|nmod|amastatin inhibited|nsubj|activity activity|amod|END_ENTITY	Aminopeptidase activity in disrupted epithelial cells was inhibited by amastatin , bestatin , and 1,10-O-phenanthroline -LRB- IC50 values of 500 nM , 1 microM , and 17 microM , respectively -RRB- , but not by captopril at the highest concentration tested , 10 mM .
1777123	4	1,10-O-phenanthroline	567,588	catalase	469,477	1,10-O-phenanthroline	catalase	null	847	Chemical	Gene	offered|nsubj|START_ENTITY observed|advcl|offered achieved|parataxis|observed achieved|nmod|inclusion inclusion|nmod|END_ENTITY	Short-term protection of hemolytic activity was achieved by inclusion of catalase in the preparation ; no apparent protection was observed by superoxide dismutase , whereas 1,10-O-phenanthroline offered long-term protection of the hemolysin .
9830036	6	1,10-O-phenanthroline	799,820	lck	763,766	1,10-O-phenanthroline	lck	null	3932	Chemical	Gene	results|amod|START_ENTITY dimers|dobj|results dimers|nsubj|p56 p56|appos|END_ENTITY	p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes .
7575672	7	1,10-O-phenanthroline	1227,1248	LTA4_hydrolase	1125,1139	1,10-O-phenanthroline	LTA4 hydrolase	null	4048	Chemical	Gene	revealed|conj|START_ENTITY values|amod|revealed cells|nmod|values examined|nmod|cells examined|nsubj|curves curves|amod|END_ENTITY	LTA4_hydrolase concentration-inhibition curves examined in intact cells with captopril , bestatin , and 1,10-O-phenanthroline revealed IC50 values of 63 , 70 , and 920 microM , respectively .
9830036	6	1,10-O-phenanthroline	799,820	p56	759,762	1,10-O-phenanthroline	p56	null	8999	Chemical	Gene	results|amod|START_ENTITY dimers|dobj|results dimers|nsubj|END_ENTITY	p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes .
9830036	6	1,10-O-phenanthroline	799,820	p56	899,902	1,10-O-phenanthroline	p56	null	8999	Chemical	Gene	results|amod|START_ENTITY results|nmod|dissociation dissociation|nmod|GST-CD4 GST-CD4|nmod|END_ENTITY	p56 -LRB- lck -RRB- dimers with the Zn2 + chelators 1,10-O-phenanthroline or 8-hydroxyquinoline-5-sulfonic_acid results in dissociation of GST-CD4 from p56 -LRB- lck -RRB- , consistent with the finding of Huse et al. -LRB- 5 -RRB- that Zn2 + is contained within similar complexes .
762062	7	1,10-orthophenanthroline	746,770	amidophosphoribosyltransferase	836,866	1,10-orthophenanthroline	amidophosphoribosyltransferase	null	5471	Chemical	Gene	Incubation|advcl|START_ENTITY Incubation|ccomp|led led|nmod|inactivation inactivation|nmod|END_ENTITY	Incubation with 1,10-orthophenanthroline , but not 1,7-metaphenanthroline or tiron , led to inactivation of amidophosphoribosyltransferase .
3278222	8	1,10-orthophenanthroline	1258,1282	gp63	1341,1345	1,10-orthophenanthroline	gp63	null	89782	Chemical	Gene	ions|conj|START_ENTITY inhibited|nsubj|ions inhibited|dobj|activity activity|nummod|END_ENTITY	Among various protease inhibitors tested , only heavy metal ions -LRB- 1 mM -RRB- , 1,10-orthophenanthroline -LRB- 1 mM -RRB- and bestatin -LRB- 100 ng ml-1 -RRB- significantly inhibited gp63 acid protease activity by up to 80 % .
1280325	4	1,10-orthophenanthroline	652,676	MyTI	618,622	1,10-orthophenanthroline	MyTI	null	4661	Chemical	Gene	eliminates|nsubj|START_ENTITY cofactor|advcl|eliminates cofactor|nmod|binding binding|nmod|END_ENTITY	Zinc is a necessary cofactor for DNA binding of MyTI , as the zinc-chelating agent 1,10-orthophenanthroline eliminates binding activity .
9315628	8	1,10-orthophenanthroline	1244,1268	p53	1360,1363	1,10-orthophenanthroline	p53	null	7157	Chemical	Gene	promoted|nsubj|START_ENTITY promoted|dobj|activity activity|nmod|copper copper|conj|activity activity|compound|END_ENTITY	In contrast , 1,10-orthophenanthroline , a cell-permeable chelator of Cu2 + , promoted the redox activity of copper and up-regulated p53 DNA-binding activity through a DNA damage-dependent pathway .
11882664	7	1,10-ortho-phenanthroline	1479,1504	galectin-3	1437,1447	1,10-ortho-phenanthroline	galectin-3	null	3958	Chemical	Gene	lactose|conj|START_ENTITY inhibited|xcomp|lactose inhibited|nmod|antagonist antagonist|amod|END_ENTITY	This cleavage was inhibited by the galectin-3 antagonist lactose , as well as 1,10-ortho-phenanthroline , suggesting that galectin-3 is cleaved by zinc metalloproteases after its binding to lipophosphoglycans .
11882664	7	1,10-ortho-phenanthroline	1479,1504	galectin-3	1522,1532	1,10-ortho-phenanthroline	galectin-3	null	3958	Chemical	Gene	lactose|conj|START_ENTITY lactose|ccomp|suggesting suggesting|ccomp|cleaved cleaved|nsubjpass|END_ENTITY	This cleavage was inhibited by the galectin-3 antagonist lactose , as well as 1,10-ortho-phenanthroline , suggesting that galectin-3 is cleaved by zinc metalloproteases after its binding to lipophosphoglycans .
1985897	6	1,10-orthophenantroline	677,700	NF-kappa_B	618,628	1,10-orthophenantroline	NF-kappa B	null	4790	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|binding binding|nmod|END_ENTITY	DNA binding of NF-kappa_B was specifically blocked by the chelating agent 1,10-orthophenantroline and could only be reconstituted by addition of Zn2 + .
23081896	9	1,10-PHEN	1227,1236	TIMP3	1238,1243	1,10-PHEN	TIMP3	null	396775(Tax:9823)	Chemical	Gene	Similar|nmod|START_ENTITY inhibited|advcl|Similar inhibited|nsubj|END_ENTITY	Similar to 1,10-PHEN , TIMP3 inhibited total fertilization rate of CI but not CF oocytes and did not influence sperm quality parameters .
1385096	7	1,10-phenanthrolene	1729,1748	IGFBP-4	1636,1643	1,10-phenanthrolene	IGFBP-4	null	3487	Chemical	Gene	inhibitors|conj|START_ENTITY prevented|nmod|inhibitors prevented|nsubjpass|decrease decrease|nmod|END_ENTITY	The IGF-dependent decrease in IGFBP-4 was prevented by coincubation of the media with serine protease inhibitors , EDTA , or 1,10-phenanthrolene , suggesting that IGFs may activate an IGFBP-4 specific metallo-serine protease present in fibroblast conditioned media .
1385096	7	1,10-phenanthrolene	1729,1748	IGFBP-4	1787,1794	1,10-phenanthrolene	IGFBP-4	null	3487	Chemical	Gene	inhibitors|conj|START_ENTITY prevented|nmod|inhibitors prevented|xcomp|suggesting suggesting|ccomp|activate activate|dobj|present present|compound|END_ENTITY	The IGF-dependent decrease in IGFBP-4 was prevented by coincubation of the media with serine protease inhibitors , EDTA , or 1,10-phenanthrolene , suggesting that IGFs may activate an IGFBP-4 specific metallo-serine protease present in fibroblast conditioned media .
8675593	10	1,10-phenanthrolene	1795,1814	IGFBP-4	1675,1682	1,10-phenanthrolene	IGFBP-4	null	3487	Chemical	Gene	ethylenediamine_tetraacetate|conj|START_ENTITY IGFs|dep|ethylenediamine_tetraacetate coincubation|nmod|IGFs prevented|nmod|coincubation prevented|nsubjpass|decrease decrease|nmod|concentrations concentrations|compound|END_ENTITY	The decrease in IGFBP-4 concentrations was prevented by coincubation of the CM with the IGFs and either ethylenediamine_tetraacetate or 1,10-phenanthrolene , but not with other protease inhibitors .
10216093	4	1-10-phenanthroline	789,808	PAI-1	859,864	1-10-phenanthroline	PAI-1	MESH:C025205	5054	Chemical	Gene	chelators|nmod|START_ENTITY chelators|conj|plasminogen_activator_inhibitor-1 plasminogen_activator_inhibitor-1|appos|END_ENTITY	Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR .
10216093	4	1-10-phenanthroline	789,808	plasminogen_activator_inhibitor-1	824,857	1-10-phenanthroline	plasminogen activator inhibitor-1	MESH:C025205	5054	Chemical	Gene	chelators|nmod|START_ENTITY chelators|conj|END_ENTITY	Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR .
10216093	4	1-10-phenanthroline	789,808	uPAR	907,911	1-10-phenanthroline	uPAR	MESH:C025205	5329	Chemical	Gene	chelators|nmod|START_ENTITY abolished|nmod|chelators abolished|nmod|END_ENTITY	Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR .
10216093	4	1-10-phenanthroline	789,808	VN	744,746	1-10-phenanthroline	VN	MESH:C025205	7448	Chemical	Gene	chelators|nmod|START_ENTITY abolished|nmod|chelators abolished|nsubjpass|adhesion adhesion|nmod|END_ENTITY	Zn2 + - induced cell adhesion to VN was abolished by cation chelators such as 1-10-phenanthroline , as well as by plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and a monoclonal antibody -LRB- MoAb -RRB- against uPAR .
2559080	5	1,10-phenanthroline	905,924	3_alpha-hydroxysteroid_dehydrogenase	941,977	1,10-phenanthroline	3 alpha-hydroxysteroid dehydrogenase	MESH:C025205	8644	Chemical	Gene	inhibitor|amod|START_ENTITY suppressed|nsubj|inhibitor suppressed|dobj|activity activity|amod|END_ENTITY	The specific inhibitor of the enzyme , 1,10-phenanthroline , suppressed the 3_alpha-hydroxysteroid_dehydrogenase activity in the crude extract of monkey liver by 50 % .
9399582	6	1,10-phenanthroline	874,893	AAP	797,800	1,10-phenanthroline	AAP	MESH:C025205	290	Chemical	Gene	leuhistin|conj|START_ENTITY bestatin|appos|leuhistin inhibited|nmod|bestatin inhibited|nsubj|END_ENTITY	AAP was potently inhibited by bestatin , leuhistin , actinonin , amastatin , and 1,10-phenanthroline .
17680773	9	1,10-phenanthroline	1673,1692	Abeta	1627,1632	1,10-phenanthroline	Abeta	MESH:C025205	351	Chemical	Gene	CQ|conj|START_ENTITY -LSB-|dobj|CQ -LSB-|nsubj|levels levels|compound|END_ENTITY	Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta .
17680773	9	1,10-phenanthroline	1673,1692	Abeta	1855,1860	1,10-phenanthroline	Abeta	MESH:C025205	351	Chemical	Gene	CQ|conj|START_ENTITY -LSB-|dobj|CQ inhibited|ccomp|-LSB- ligands|acl:relcl|inhibited induced|nsubj|ligands induced|advcl|resulting resulting|nmod|up-regulation up-regulation|conj|loss loss|nmod|END_ENTITY	Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta .
18463291	4	1,10-phenanthroline	432,451	Abeta	510,515	1,10-phenanthroline	Abeta	MESH:C025205	11820(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY L|ccomp|derivatives range|dep|L bind|nsubj|range bind|nmod|END_ENTITY	To test this hypothesis , a range of L-PtCl -LRB- 2 -RRB- -LRB- L = 1,10-phenanthroline derivatives -RRB- complexes were examined and shown to bind to Abeta , inhibit neurotoxicity and rescue Abeta-induced synaptotoxicity in mouse hippocampal slices .
18463291	7	1,10-phenanthroline	931,950	Abeta	989,994	1,10-phenanthroline	Abeta	MESH:C025205	11820(Tax:10090)	Chemical	Gene	planar|amod|START_ENTITY ligands|nsubj|planar ligands|ccomp|confer confer|dobj|specificity specificity|nmod|END_ENTITY	This implies that the planar aromatic 1,10-phenanthroline ligands L confer some specificity for Abeta onto the platinum complexes .
2965871	2	1,10-phenanthroline	320,339	ACE	486,489	1,10-phenanthroline	ACE	MESH:C025205	24310(Tax:10116)	Chemical	Gene	ANP|conj|START_ENTITY ANP|conj|phenylmethylsulphonyl_fluoride phenylmethylsulphonyl_fluoride|conj|SQ_20881 SQ_20881|compound|END_ENTITY	Degradation of -LSB- 125I -RSB- - ANP is antagonized by unlabelled ANP , bradykinin , glucagon , 1,10-phenanthroline , PCMB , EDTA and the bacterial antibiotic bacitracin , but not by phenylmethylsulphonyl_fluoride , aprotinin , phosphoramidon , E-64 , amastatin or the ACE inhibitor SQ_20881 and bradykinin_potentiator_C .
6259546	2	1,10-phenanthroline	386,405	acetylcholinesterase	348,368	1,10-phenanthroline	acetylcholinesterase	MESH:C025205	11423(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|release release|nmod|END_ENTITY	The collagenase-stimulated release of acetylcholinesterase was inhibited by 1,10-phenanthroline , an inhibitor of collagenase .
23408593	5	1,10-phenanthroline	656,675	AChE	693,697	1,10-phenanthroline	AChE	MESH:C025205	43	Chemical	Gene	effect|nmod|START_ENTITY high|nsubj|effect high|nmod|activity activity|compound|END_ENTITY	The inhibitory effect of 1,10-phenanthroline was high towards AChE esterase activity .
23408593	7	1,10-phenanthroline	922,941	AChE	907,911	1,10-phenanthroline	AChE	MESH:C025205	43	Chemical	Gene	inhibits|amod|START_ENTITY esterase|nsubj|inhibits show|ccomp|esterase show|nsubj|studies studies|nmod|forms forms|nmod|END_ENTITY	Kinetic studies on both forms of AChE show that 1,10-phenanthroline inhibits esterase in competitive and AAA activity in non-competitive manner .
23408593	8	1,10-phenanthroline	1074,1093	AChE	1108,1112	1,10-phenanthroline	AChE	MESH:C025205	43	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Protection studies further revealed that the nature of 1,10-phenanthroline inhibition on AChE is through its direct binding to protein rather than its metal chelation property .
3161078	4	1,10-phenanthroline	785,804	ADH	1018,1021	1,10-phenanthroline	ADH	MESH:C025205	10327	Chemical	Gene	4-Methylpyrazole|conj|START_ENTITY inhibit|dep|4-Methylpyrazole inhibit|nsubj|oxidation oxidation|acl|indicating indicating|ccomp|interact interact|nmod|site site|nmod|END_ENTITY	4-Methylpyrazole and 1,10-phenanthroline inhibit the class I ADH-catalyzed oxidation of HMPG , DHPG , and ethanol with inhibition constants of 75-90 nM and 19-22 microM , respectively , indicating that these substrates interact at the same catalytic site of ADH .
2157617	6	1,10-phenanthroline	970,989	AhR	1123,1126	1,10-phenanthroline	AhR	MESH:C025205	196	Chemical	Gene	inhibited|nsubj|START_ENTITY observed|advcl|inhibited observed|nsubj|inhibition inhibition|nmod|END_ENTITY	Here , we report that although 1,10-phenanthroline , a metal ion chelating agent , inhibited the DNA binding of SP1_and_transformed_glucocorticoid_receptor , no inhibition of transformed AhR was observed .
2160969	7	1,10-phenanthroline	989,1008	AH_receptor	1085,1096	1,10-phenanthroline	AH receptor	MESH:C025205	25690(Tax:10116)	Chemical	Gene	chelators|amod|START_ENTITY inhibited|nsubj|chelators inhibited|dobj|activity activity|nmod|END_ENTITY	The chelators 1,10-phenanthroline and oxalic_acid inhibited the sequence-specific DNA-binding activity of the AH_receptor in a concentration dependent manner , suggesting that the DNA-binding activity of the receptor requires divalent metal ions .
19896525	1	1,10-phenanthroline	96,115	AKR1C1	202,208	1,10-phenanthroline	AKR1C1	MESH:C025205	1645	Chemical	Gene	phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|nmod|aldo-keto_reductases_1C1 aldo-keto_reductases_1C1|appos|END_ENTITY	1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level .
6716101	5	1,10-phenanthroline	390,409	ALAD	367,371	1,10-phenanthroline	ALAD	MESH:C025205	510679(Tax:9913)	Chemical	Gene	inactivated|nmod|START_ENTITY inactivated|nsubjpass|END_ENTITY	ALAD is inactivated by 1,10-phenanthroline or ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- but not by monodentate anions like cyanide or sulfide .
21515032	0	1,10-phenanthroline	98,117	albumin	12,19	1,10-phenanthroline	albumin	MESH:C025205	213	Chemical	Gene	ligand|amod|START_ENTITY containing|dobj|ligand complex|acl|containing studies|nmod|complex END_ENTITY|dobj|studies	Human serum albumin binding and cytotoxicity studies of surfactant-cobalt -LRB- III -RRB- complex containing 1,10-phenanthroline ligand .
6986372	1	1,10-phenanthroline	168,187	alcohol_dehydrogenase	122,143	1,10-phenanthroline	alcohol dehydrogenase	MESH:C025205	10327	Chemical	Gene	chelation|acl|START_ENTITY studied|nsubjpass|chelation studied|advcl|elucidate elucidate|nmod|catalysis catalysis|compound|END_ENTITY	To elucidate the role of zinc-bound water in liver alcohol_dehydrogenase catalysis , chelation by 1,10-phenanthroline and 2,2-bipyridine was studied .
19896525	1	1,10-phenanthroline	96,115	aldo-keto_reductases_1C1	176,200	1,10-phenanthroline	aldo-keto reductases 1C1	MESH:C025205	1645	Chemical	Gene	phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|nmod|END_ENTITY	1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level .
2173552	20	1,10-phenanthroline	1674,1693	alpha_1-AT	1637,1647	1,10-phenanthroline	alpha 1-AT	MESH:C025205	5265	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|cleavage cleavage|amod|END_ENTITY	alpha_1-AT cleavage was inhibited by 1,10-phenanthroline and by high concentrations of collagen .
1711895	3	1,10-phenanthroline	543,562	alpha_2-macroglobulin	480,501	1,10-phenanthroline	alpha 2-macroglobulin	MESH:C025205	2	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|nmod|END_ENTITY	The purified enzyme was completely inhibited by alpha_2-macroglobulin and the chelating agents EDTA , EGTA , and 1,10-phenanthroline and was slightly inhibited by chymostatin and pepstatin , but was not inhibited by various other serine and thiol protease inhibitors .
2804981	2	1,10-phenanthroline	520,539	alpha-MSH	486,495	1,10-phenanthroline	alpha-MSH	MESH:C025205	5443	Chemical	Gene	mM|amod|START_ENTITY presence|nmod|mM END_ENTITY|nmod|presence	Specific binding of high-performance liquid chromatography-purified , monoiodinated alpha-MSH in the presence of 1 mM 1,10-phenanthroline as protease inhibitor was highest after a 2-h incubation at 37 degrees C .
8024692	6	1,10-phenanthroline	1161,1180	alpha-tubulin	1220,1233	1,10-phenanthroline	alpha-tubulin	MESH:C025205	10376	Chemical	Gene	tested|nsubj|START_ENTITY tested|dobj|levels levels|amod|END_ENTITY	In the presence of insulin , Northern analysis revealed that 1,10-phenanthroline at all concentrations tested increased alpha-tubulin mRNA levels , but had a biphasic effect on insulin-stimulated immediate-early gene expression .
8024692	9	1,10-phenanthroline	1680,1699	alpha-tubulin	1802,1815	1,10-phenanthroline	alpha-tubulin	MESH:C025205	10376	Chemical	Gene	concentrations|nmod|START_ENTITY decreased|nsubj|concentrations decreased|conj|had had|dobj|effect effect|nmod|transcription transcription|nmod|END_ENTITY	Nuclear run-on analysis demonstrated that high concentrations of 1,10-phenanthroline decreased insulin-stimulated immediate-early gene transcription but had no effect on transcription of alpha-tubulin .
10649451	5	1,10-phenanthroline	600,619	aminopeptidase	676,690	1,10-phenanthroline	aminopeptidase	MESH:C025205	856811(Tax:4932)	Chemical	Gene	PMSF|amod|START_ENTITY inhibitors|nsubj|PMSF inhibitors|nmod|activity activity|amod|END_ENTITY	PMSF , Cu -LRB- 2 + -RRB- , 1,10-phenanthroline and bestatin were found to be very strong inhibitors of aminopeptidase yscCo-II activity .
1417757	4	1,10-phenanthroline	521,540	aminopeptidase	568,582	1,10-phenanthroline	aminopeptidase	MESH:C025205	100533385	Chemical	Gene	agent|amod|START_ENTITY inhibited|nsubj|agent inhibited|dobj|activity activity|compound|END_ENTITY	The bivalent-cation-chelating agent , 1,10-phenanthroline , inhibited kidney membrane aminopeptidase activity with an IC50 of 30 microM , suggesting that this enzyme is a metalloproteinase .
16666602	6	1,10-phenanthroline	876,895	aminopeptidase	750,764	1,10-phenanthroline	aminopeptidase	MESH:C025205	10404	Chemical	Gene	SH-reagents|conj|START_ENTITY inhibited|nmod|SH-reagents inhibited|nsubjpass|activity activity|nmod|II II|amod|END_ENTITY	The activity of aminopeptidase II was inhibited by the SH-reagents p-chloromercuribenzoic_acid and N-ethylmaleimide and by the metal chelator 1,10-phenanthroline .
21167291	7	1,10-phenanthroline	1242,1261	aminopeptidase	1182,1196	1,10-phenanthroline	aminopeptidase	MESH:C025205	10404	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|nsubj|activity activity|amod|END_ENTITY	The aminopeptidase activity upon LpNA was inhibited by EDTA and 1,10-phenanthroline , indicating the importance of metal ions in enzyme catalysis .
2607648	3	1,10-phenanthroline	510,529	aminopeptidase	401,415	1,10-phenanthroline	aminopeptidase	MESH:C025205	10404	Chemical	Gene	derivatives|amod|START_ENTITY selected|nmod|derivatives selected|nsubjpass|such such|nmod|END_ENTITY	At first , more specific and adequate inhibitor for other serum peptidases , such as membrane-bound aminopeptidase -LRB- EC 3.4.11.2 ; arylamidase , AA -RRB- and cystyl aminopeptidase -LRB- EC 3.4.11.3 ; CAP -RRB- was selected from 1,10-phenanthroline derivatives .
2607648	3	1,10-phenanthroline	510,529	aminopeptidase	458,472	1,10-phenanthroline	aminopeptidase	MESH:C025205	10404	Chemical	Gene	derivatives|amod|START_ENTITY selected|nmod|derivatives selected|nsubjpass|such such|nmod|aminopeptidase END_ENTITY|conj|aminopeptidase	At first , more specific and adequate inhibitor for other serum peptidases , such as membrane-bound aminopeptidase -LRB- EC 3.4.11.2 ; arylamidase , AA -RRB- and cystyl aminopeptidase -LRB- EC 3.4.11.3 ; CAP -RRB- was selected from 1,10-phenanthroline derivatives .
1967220	5	1,10-phenanthroline	1234,1253	Aminopeptidase	1053,1067	1,10-phenanthroline	Aminopeptidase	MESH:C025205	10404	Chemical	Gene	blocked|nmod|START_ENTITY demonstrated|conj|blocked demonstrated|nsubjpass|activity activity|amod|END_ENTITY	Aminopeptidase activity was demonstrated for CD13 molecules specifically immunoprecipitated from the surface of CD13-positive cells and was blocked by the metalloprotease inhibitor 1,10-phenanthroline .
8141778	3	1,10-phenanthroline	678,697	aminopeptidase_A	777,793	1,10-phenanthroline	aminopeptidase A	MESH:C025205	2028	Chemical	Gene	amastatin|conj|START_ENTITY inhibition|nmod|amastatin characteristic|nsubj|inhibition characteristic|nmod|END_ENTITY	The inhibition by amastatin and 1,10-phenanthroline , and the activation by CaCl2 are characteristic of the cell-surface ectoenzyme aminopeptidase_A -LRB- EC 3.4.11.7 -RRB- and a purified preparation of this enzyme hydrolysed aspartame with a Km of 0.25 mM and a Vmax of 126 mumol/min per mg .
2875994	3	1,10-phenanthroline	552,571	aminopeptidase_M	633,649	1,10-phenanthroline	aminopeptidase M	MESH:C025205	81641(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	S - -LRB- 1,2-Dichlorovinyl -RRB- - L-cysteinylglycine , a putative metabolite of DCVG , also produced cell death , which was prevented by 1,10-phenanthroline , phenylalanylglycine , and aminooxyacetic_acid , inhibitors of aminopeptidase_M , cysteinylglycine dipeptidase , and cysteine conjugate beta-lyase , respectively .
9602161	3	1,10-phenanthroline	654,673	aminopeptidase_N	574,590	1,10-phenanthroline	aminopeptidase N	MESH:C025205	100127099(Tax:7091)	Chemical	Gene	inhibited|nsubj|START_ENTITY estimated|conj|inhibited estimated|nsubjpass|content content|nmod|END_ENTITY	The zinc content in purified aminopeptidase_N was estimated as approximately 0.72 mol/mol of the protein and 1,10-phenanthroline completely inhibited the enzyme activity , suggesting zinc requirement for the activity .
14612196	4	1,10-phenanthroline	467,486	Ang_1-9	407,414	1,10-phenanthroline	Ang 1-9	MESH:C025205	305843(Tax:10116)	Chemical	Gene	inhibitor|conj|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubjpass|formation formation|nmod|END_ENTITY	The formation of Ang_1-9 was inhibited by potato carboxypeptidase inhibitor , 1,10-phenanthroline or EDTA .
18838088	4	1,10-phenanthroline	1072,1091	Ang_II	1024,1030	1,10-phenanthroline	Ang II	MESH:C025205	24179(Tax:10116)	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nsubjpass|cleavage cleavage|acl|Ang Ang|xcomp|Ang Ang|dobj|conversion conversion|conj|END_ENTITY	The respective reactions , namely , Z-Val-Phe cleavage , Ang I to Ang 1-9 conversion and Ang_II to Ang 1-7 conversion , were inhibited by 1,10-phenanthroline and nearly fully blocked by potato carboxypeptidase inhibitor .
2317196	14	1,10-phenanthroline	2112,2131	angiotensin-converting_enzyme	2150,2179	1,10-phenanthroline	angiotensin-converting enzyme	MESH:C025205	613133(Tax:9823)	Chemical	Gene	di-isopropylfluorophosphate|conj|START_ENTITY di-isopropylfluorophosphate|conj|END_ENTITY	Various inhibitors were tested ; a few reagents , such as organic mercurials , di-isopropylfluorophosphate , 1,10-phenanthroline , sodium_azide and angiotensin-converting_enzyme inhibitor exhibited some inhibition -LRB- not more than 60 % -RRB- .
2983769	5	1,10-phenanthroline	775,794	angiotensin-converting_enzyme	686,715	1,10-phenanthroline	angiotensin-converting enzyme	MESH:C025205	24310(Tax:10116)	Chemical	Gene	EDTA|conj|START_ENTITY chelators|amod|EDTA inhibition|nmod|chelators inhibition|nsubj|END_ENTITY	Purified pulmonary angiotensin-converting_enzyme was more sensitive to inhibition by the chelators EDTA and 1,10-phenanthroline and by the site-directed inhibitor captopril than was the testicular isozyme .
3007669	1	1,10-phenanthroline	148,167	Angiotensin_converting_enzyme	89,118	1,10-phenanthroline	Angiotensin converting enzyme	MESH:C025205	1636	Chemical	Gene	form|nsubj|START_ENTITY chelator|acl|form interacts|nmod|chelator interacts|nsubj|END_ENTITY	Angiotensin_converting_enzyme interacts with the chelator , 1,10-phenanthroline -LRB- OP -RRB- to form an OP-Zn-ACE ternary complex , which subsequently dissociates to OP-Zn and apoenzyme .
17145192	4	1,10-phenanthroline	717,736	angiotensin_I	829,842	1,10-phenanthroline	angiotensin I	MESH:C025205	183	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|advcl|EDTA inhibited|conj|released released|nmod|END_ENTITY	gACE was potently inhibited by EDTA , 1,10-phenanthroline , captopril and lisinopril , and it promptly released the dipeptides_His-Leu and Phe-Arg from angiotensin_I and bradykinin .
16297670	6	1,10-phenanthroline	1128,1147	AphA	1058,1062	1,10-phenanthroline	AphA	MESH:C025205	948562(Tax:511145)	Chemical	Gene	agents|amod|START_ENTITY inhibited|nmod|agents inhibited|nsubjpass|END_ENTITY	AphA was inhibited by several chelating agents , including EDTA , EGTA , 1,10-phenanthroline and dipicolinic_acid , with EDTA being apparently the most powerful inhibitor .
17109655	2	1,10-phenanthroline	483,502	AP-N	565,569	1,10-phenanthroline	AP-N	MESH:C025205	290	Chemical	Gene	produced|nsubj|START_ENTITY produced|dobj|inhibition inhibition|nmod|END_ENTITY	Whereas pre-incubation for 10 min with ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- , did not or only weakly affected the enzyme activity , the bidentate chelator 1,10-phenanthroline produced a complete and concentration-dependent inhibition of AP-N .
1720775	5	1,10-phenanthroline	697,716	Apn1	630,634	1,10-phenanthroline	Apn1	MESH:C025205	853746(Tax:4932)	Chemical	Gene	treated|nmod|START_ENTITY IV|acl|treated ineffective|nmod|IV reactivated|conj|ineffective reactivated|dobj|END_ENTITY	ZnCl2 reactivated 1,10-phenanthroline-treated Apn1 , but was ineffective with endonuclease IV treated with either 1,10-phenanthroline or EDTA .
10875440	3	1,10-phenanthroline	661,680	APP	726,729	1,10-phenanthroline	APP	MESH:C025205	100689222	Chemical	Gene	presence|nmod|START_ENTITY concentrations|conj|presence up|nmod|concentrations zinc|advmod|up increased|nsubj|zinc increased|dobj|level level|nmod|END_ENTITY	The data show that zinc up to concentrations of 50 microM or the presence of 1,10-phenanthroline specifically increased the level of secreted APP in CHO-K1 cells .
1510698	8	1,10-phenanthroline	822,841	APP	802,805	1,10-phenanthroline	APP	MESH:C025205	351	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nsubjpass|END_ENTITY	Platelet APP is inhibited by 1,10-phenanthroline and activated by Mn2 + , thus confirming its metalloprotease nature .
11106490	7	1,10-phenanthroline	1017,1036	AP-P	1107,1111	1,10-phenanthroline	AP-P	MESH:C025205	351	Chemical	Gene	START_ENTITY|conj|inhibitor inhibitor|nmod|form form|nmod|END_ENTITY	Hydrolysis of bradykinin was inhibited by 1,10-phenanthroline and by the specific inhibitor of the membrane-bound form of mammalian AP-P , apstatin .
8460139	3	1,10-phenanthroline	826,845	arcA	718,722	1,10-phenanthroline	arcA	MESH:C025205	9845996	Chemical	Gene	dehydrogenase|nmod|START_ENTITY induction|conj|dehydrogenase dependent|nsubj|induction caused|parataxis|dependent caused|ccomp|fnr fnr|nsubj|induction induction|nmod|MnSOD MnSOD|nmod|END_ENTITY	Metal chelating agents also caused anaerobic induction of MnSOD in a fur arcA fnr triple mutant ; however , this induction of MnSOD and of glucose-6-phosphate dehydrogenase -LRB- G6PD -RRB- by 1,10-phenanthroline was dependent on an intact soxRS locus .
12450410	6	1,10-phenanthroline	541,560	AtzA	518,522	1,10-phenanthroline	AtzA	MESH:C025205	1440573(Tax:47660)	Chemical	Gene	chelator|amod|START_ENTITY incubating|nmod|chelator incubating|dobj|END_ENTITY	Loss of activity obtained by incubating AtzA with the chelator 1,10-phenanthroline or oxalic_acid was reversible upon addition of Fe -LRB- II -RRB- , Mn -LRB- II -RRB- , or Co -LRB- II -RRB- salts .
9030778	5	1,10-phenanthroline	1017,1036	axonin-1	1118,1126	1,10-phenanthroline	axonin-1	MESH:C025205	419825(Tax:9031)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|nmod|END_ENTITY	Secreted axonin-1 does not exhibit the cross-reacting determinant epitope , an indication that the cleavage of the anchor is not mediated by a phosphatidylinositol-specific phospholipase C. Treatment of dorsal root ganglion neurons with 1,10-phenanthroline , an inhibitor of glycosylPtdIns-specific phospholipase D , reduces the release of axonin-1 by 56 % .
9030778	5	1,10-phenanthroline	1017,1036	axonin-1	790,798	1,10-phenanthroline	axonin-1	MESH:C025205	419825(Tax:9031)	Chemical	Gene	reduces|nsubj|START_ENTITY exhibit|dep|reduces exhibit|dep|END_ENTITY	Secreted axonin-1 does not exhibit the cross-reacting determinant epitope , an indication that the cleavage of the anchor is not mediated by a phosphatidylinositol-specific phospholipase C. Treatment of dorsal root ganglion neurons with 1,10-phenanthroline , an inhibitor of glycosylPtdIns-specific phospholipase D , reduces the release of axonin-1 by 56 % .
11928813	7	1,10-phenanthroline	1293,1312	BB3103	1282,1288	1,10-phenanthroline	BB3103	MESH:C025205	2663635(Tax:257310)	Chemical	Gene	inhibitors|conj|START_ENTITY inhibitors|conj|END_ENTITY	The finding that both neuroblastoma clones exposed to the metalloproteinase inhibitors , BB3103 and 1,10-phenanthroline , increased their differentiative capacity and reduced their invasiveness through Matrigel , represents a further indication that PAF modulates differentiation and invasiveness by affecting the activity of MMPs .
19505802	3	1,10-phenanthroline	424,443	BB-3497	404,411	1,10-phenanthroline	BB-3497	MESH:C025205	2659607(Tax:257310)	Chemical	Gene	END_ENTITY|conj|START_ENTITY	In the present study , various well-known PDF inhibitors , such as BB-3497 , actinonin , 1,10-phenanthroline , hydroxylamine_hydrochloride and galardin , were selected to evaluate their inhibitory activity against Mycobacterium_tuberculosis .
19505802	5	1,10-phenanthroline	801,820	BB-3497	789,796	1,10-phenanthroline	BB-3497	MESH:C025205	2659607(Tax:257310)	Chemical	Gene	END_ENTITY|conj|START_ENTITY	BB-3497 and 1,10-phenanthroline exhibited potent in vitro antimycobacterial activity , and also showed synergism with isoniazid and rifampicin .
15990199	7	1,10-phenanthroline	1198,1217	BDNF	1156,1160	1,10-phenanthroline	BDNF	MESH:C025205	24225(Tax:10116)	Chemical	Gene	abolished|nsubj|START_ENTITY microglia|acl:relcl|abolished expression|nmod|microglia contrast|dep|expression contrast|appos|END_ENTITY	These profiles contrast to the data with morphine-induced enhancement of brain-derived growth factor -LRB- BDNF -RRB- gene expression in microglia , where 1,10-phenanthroline abolished the expression .
10604529	1	1,10-phenanthroline	487,506	BK2	589,592	1,10-phenanthroline	BK2	MESH:C025205	624	Chemical	Gene	nitroarginine|conj|START_ENTITY prevented|nmod|nitroarginine prevented|conj|involve involve|dobj|receptors receptors|compound|BK1 BK1|conj|END_ENTITY	Such a potentiation was prevented and reversed only by nitroarginine or 1,10-phenanthroline -LRB- PHE -RRB- -LRB- which also reduced basal jugular NO levels -RRB- and did not involve the BK1 or BK2 receptors .
11106490	7	1,10-phenanthroline	1017,1036	bradykinin	989,999	1,10-phenanthroline	bradykinin	MESH:C025205	3827	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Hydrolysis Hydrolysis|nmod|END_ENTITY	Hydrolysis of bradykinin was inhibited by 1,10-phenanthroline and by the specific inhibitor of the membrane-bound form of mammalian AP-P , apstatin .
17145192	4	1,10-phenanthroline	717,736	bradykinin	847,857	1,10-phenanthroline	bradykinin	MESH:C025205	3827	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|advcl|EDTA inhibited|conj|released released|nmod|angiotensin_I angiotensin_I|conj|END_ENTITY	gACE was potently inhibited by EDTA , 1,10-phenanthroline , captopril and lisinopril , and it promptly released the dipeptides_His-Leu and Phe-Arg from angiotensin_I and bradykinin .
3039382	6	1,10-phenanthroline	747,766	bradykinin	794,804	1,10-phenanthroline	bradykinin	MESH:C025205	3827	Chemical	Gene	did|nsubj|START_ENTITY did|dobj|breakdown breakdown|nmod|END_ENTITY	1,10-phenanthroline did attenuate breakdown of bradykinin but this was found not to be significant compared with controls .
21491938	1	1,10-phenanthroline	168,187	C-3	91,94	1,10-phenanthroline	C-3	MESH:C025205	718	Chemical	Gene	using|xcomp|START_ENTITY time|acl|using developed|nmod|time developed|nsubjpass|olefination olefination|compound|END_ENTITY	Pd-catalyzed C-3 selective olefination of pyridines is developed for the first time using 1,10-phenanthroline as the ligand .
2158096	4	1,10-phenanthroline	487,506	CAP	391,394	1,10-phenanthroline	CAP	MESH:C025205	20468888	Chemical	Gene	chelator|amod|START_ENTITY incorporation|nmod|chelator converted|nmod|incorporation converted|nsubjpass|END_ENTITY	In this work , CAP has been converted into a site-specific DNA cleavage agent by incorporation of the chelator 1,10-phenanthroline at amino_acid 10 of the helix-turn-helix motif .
9922230	9	1,10-phenanthroline	1357,1376	CAP1	1193,1197	1,10-phenanthroline	CAP1	MESH:C025205	853862(Tax:4932)	Chemical	Gene	cadmium|conj|START_ENTITY caused|nmod|cadmium affect|conj|caused affect|nsubj|deletion deletion|nmod|END_ENTITY	We found that deletion of CAP1 did not affect the susceptibility of CJD21 cells to FCZ , cerulenin , brefeldin_A , and diamide but caused hypersensitivity to cadmium , 4-nitroquinoline_N-oxide , 1,10-phenanthroline , and hydrogen_peroxide , an effect which was reverted by reintroduction of the CAP1 gene in these cells .
9922230	9	1,10-phenanthroline	1357,1376	CAP1	1455,1459	1,10-phenanthroline	CAP1	MESH:C025205	853862(Tax:4932)	Chemical	Gene	cadmium|conj|START_ENTITY cadmium|appos|effect effect|acl:relcl|reverted reverted|nmod|reintroduction reintroduction|nmod|gene gene|compound|END_ENTITY	We found that deletion of CAP1 did not affect the susceptibility of CJD21 cells to FCZ , cerulenin , brefeldin_A , and diamide but caused hypersensitivity to cadmium , 4-nitroquinoline_N-oxide , 1,10-phenanthroline , and hydrogen_peroxide , an effect which was reverted by reintroduction of the CAP1 gene in these cells .
1793037	5	1,10-phenanthroline	833,852	carboxypeptidase_B	890,908	1,10-phenanthroline	carboxypeptidase B	MESH:C025205	24271(Tax:10116)	Chemical	Gene	captopril|conj|START_ENTITY coinjection|nmod|captopril increased|nmod|coinjection increased|conj|prevented prevented|nmod|END_ENTITY	The hyperalgesic effect of BK -LRB- 1 micrograms -RRB- injected into the hindpaw of rats was significantly increased and prolonged by coinjection of captopril -LRB- 30 micrograms -RRB- and 1,10-phenanthroline -LRB- 30 micrograms -RRB- and was prevented by carboxypeptidase_B -LRB- 1 mg -RRB- .
6326144	8	1,10-phenanthroline	1712,1731	carboxypeptidase_B	1635,1653	1,10-phenanthroline	carboxypeptidase B	MESH:C025205	24271(Tax:10116)	Chemical	Gene	EDTA|conj|START_ENTITY chelators|amod|EDTA inhibitors|conj|chelators inhibitors|conj|inhibitor inhibitor|compound|END_ENTITY	Inhibition by the zinc metallocarboxypeptidase inhibitors guanidinopropylsuccinic_acid , aminomercaptosuccinic_acid , benzylsuccinic_acid , 2-mercaptomethyl-3-guanidinoethylthiopropanoic_acid , and the potato carboxypeptidase_B inhibitor , and inhibition by the metal chelators EDTA and 1,10-phenanthroline demonstrate metal ion dependence of the pituitary granule carboxypeptidase activities .
10190127	7	1,10-phenanthroline	1185,1204	caspase_3	1211,1220	1,10-phenanthroline	caspase 3	MESH:C025205	836	Chemical	Gene	ammonium_pyrrolidinedithiocarbamate|conj|START_ENTITY ammonium_pyrrolidinedithiocarbamate|conj|inhibitor inhibitor|amod|END_ENTITY	Hydrogen_peroxide-induced cell injury and DNA fragmentation were attenuated by the NF-kappa B inhibitor ammonium_pyrrolidinedithiocarbamate , 1,10-phenanthroline and a caspase_3 inhibitor .
17251461	5	1,10-phenanthroline	619,638	cathepsin_B	658,669	1,10-phenanthroline	cathepsin B	MESH:C025205	1508	Chemical	Gene	GM-6001|dep|START_ENTITY MMPs|appos|GM-6001 MMPs|conj|cathepsins cathepsins|appos|E64 E64|dep|II II|compound|END_ENTITY	In HLE/DAM cultures , inhibitors of MMPs -LRB- GM-6001 ; 1,10-phenanthroline -RRB- , cathepsins -LRB- E64 ; cathepsin_B inhibitor II -RRB- , elastase -LRB- elastatinal -RRB- , and serine proteases -LRB- AEBSF ; aprotinin -RRB- were added .
22957890	1	1,10-phenanthroline	249,268	CCR1	142,146	1,10-phenanthroline	CCR1	MESH:C025205	1230	Chemical	Gene	bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nmod|receptors receptors|appos|END_ENTITY	Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- .
24083637	2	1,10-phenanthroline	423,442	CCR1	308,312	1,10-phenanthroline	CCR1	MESH:C025205	1230	Chemical	Gene	terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|END_ENTITY	We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine .
22957890	1	1,10-phenanthroline	249,268	CCR4	148,152	1,10-phenanthroline	CCR4	MESH:C025205	1233	Chemical	Gene	bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|END_ENTITY	Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- .
22957890	1	1,10-phenanthroline	249,268	CCR5	154,158	1,10-phenanthroline	CCR5	MESH:C025205	1234	Chemical	Gene	bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|CCR4 CCR4|conj|END_ENTITY	Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- .
24083637	2	1,10-phenanthroline	423,442	CCR5	324,328	1,10-phenanthroline	CCR5	MESH:C025205	1234	Chemical	Gene	terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|CCR1 CCR1|conj|END_ENTITY	We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine .
22957890	1	1,10-phenanthroline	249,268	CCR8	164,168	1,10-phenanthroline	CCR8	MESH:C025205	1237	Chemical	Gene	bipyridine|conj|START_ENTITY complex|amod|bipyridine activated|nmod|complex activated|nsubjpass|CCR4 CCR4|conj|END_ENTITY	Among 18 human chemokine receptors , CCR1 , CCR4 , CCR5 , and CCR8 were activated by metal ion Zn -LRB- II -RRB- or Cu -LRB- II -RRB- in complex with 2,2 ' - bipyridine or 1,10-phenanthroline with similar potencies -LRB- EC -LRB- 50 -RRB- from 3.9 to 172 M -RRB- .
24083637	2	1,10-phenanthroline	423,442	CCR8	314,318	1,10-phenanthroline	CCR8	MESH:C025205	1237	Chemical	Gene	terpyridine|nsubj|START_ENTITY published|parataxis|terpyridine published|xcomp|agonists agonists|nsubj|CCR1 CCR1|conj|END_ENTITY	We recently published CCR1 , CCR8 , and CCR5 agonists and positive modulators based on a three metal-ion chelator series : 2,2 ' - bipyridine , 1,10-phenanthroline , and 2,2 ' ; 6 ' ,2 ___ - terpyridine .
7529789	8	1,10-phenanthroline	1077,1096	CD106	1229,1234	1,10-phenanthroline	CD106	MESH:C025205	7412	Chemical	Gene	EDTA|conj|START_ENTITY inhibit|nsubj|EDTA inhibit|dobj|conversion conversion|nmod|membrane membrane|acl|anchored anchored|nmod|form form|nmod|molecule molecule|compound|END_ENTITY	EDTA and 1,10-phenanthroline , two potent inhibitors of metalloproteases , specifically inhibit the conversion of the membrane anchored to the soluble form of the CD106 molecule .
1967220	5	1,10-phenanthroline	1234,1253	CD13	1098,1102	1,10-phenanthroline	CD13	MESH:C025205	290	Chemical	Gene	blocked|nmod|START_ENTITY demonstrated|conj|blocked demonstrated|nmod|molecules molecules|nummod|END_ENTITY	Aminopeptidase activity was demonstrated for CD13 molecules specifically immunoprecipitated from the surface of CD13-positive cells and was blocked by the metalloprotease inhibitor 1,10-phenanthroline .
1834741	8	1,10-phenanthroline	1092,1111	CD16	1082,1086	1,10-phenanthroline	CD16	MESH:C025205	2214	Chemical	Gene	inhibits|amod|START_ENTITY END_ENTITY|conj|inhibits	Murine P815 mastocytoma cells transfected with human CD16-II cDNA shed membrane CD16 , and 1,10-phenanthroline inhibits this process .
7507963	4	1,10-phenanthroline	395,414	CD16	596,600	1,10-phenanthroline	CD16	MESH:C025205	2214	Chemical	Gene	inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|CD43 CD43|conj|END_ENTITY	Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes .
17467053	7	1,10-phenanthroline	1127,1146	CD34	1092,1096	1,10-phenanthroline	CD34	MESH:C025205	947	Chemical	Gene	pretreatment|amod|START_ENTITY decreased|nmod|pretreatment decreased|advcl|induced induced|dobj|migration migration|conj|END_ENTITY	While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment .
20417561	6	1,10-phenanthroline	711,730	CD4	590,593	1,10-phenanthroline	CD4	MESH:C025205	920	Chemical	Gene	inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited Lck|nmod|interaction associate|nmod|Lck associate|nsubj|END_ENTITY	CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline .
20417561	7	1,10-phenanthroline	826,845	CD4	755,758	1,10-phenanthroline	CD4	MESH:C025205	920	Chemical	Gene	presence|nmod|START_ENTITY abolished|nmod|presence abolished|nsubjpass|END_ENTITY	Here we show that both CD4 and CD44-mediated T cell spreading is abolished in the presence of 1,10-phenanthroline and their association with Lck is significantly reduced .
7507963	4	1,10-phenanthroline	395,414	CD43	580,584	1,10-phenanthroline	CD43	MESH:C025205	6693	Chemical	Gene	inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|END_ENTITY	Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes .
7683406	6	1,10-phenanthroline	1138,1157	CD43	1058,1062	1,10-phenanthroline	CD43	MESH:C025205	6693	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Importantly , PMA-induced down-regulation of CD43 on granulocytes was markedly blocked both by the metalloprotease inhibitor 1,10-phenanthroline and by the serine protease inhibitors N_alpha - -LRB- p-tosyl -RRB- - L-lysine_chloromethyl_ketone and Pefabloc SC , which inhibit two different classes of proteases , thus indicating that the release is proteolytic .
10050880	8	1,10-phenanthroline	1113,1132	CD44	1161,1165	1,10-phenanthroline	CD44	MESH:C025205	960	Chemical	Gene	treatment|nmod|START_ENTITY treatment|acl:relcl|prevent prevent|dobj|cleavage cleavage|compound|END_ENTITY	Interestingly , treatment with the metalloprotease blocker 1,10-phenanthroline , which strongly prevent the CD44 cleavage , suppressed RERF-LC-OK lung_cancer cell migration on a hyaluronate substrate , but not on several other substrates .
17912438	10	1,10-phenanthroline	1745,1764	CD44	1533,1537	1,10-phenanthroline	CD44	MESH:C025205	960	Chemical	Gene	inhibited|conj|START_ENTITY membranes|acl:relcl|inhibited migrate|nmod|membranes invade|conj|migrate enhances|xcomp|invade enhances|nsubj|crosslinking crosslinking|nmod|END_ENTITY	Furthermore , crosslinking of CD44 enhances the ability of breast_tumor cells to invade G8 myoblast monolayers and migrate through the basal membranes which was inhibited in the presence of anti-MMP-9 antibody or the MMP inhibitors GM6001 or 1,10-phenanthroline .
7507963	4	1,10-phenanthroline	395,414	CD44	586,590	1,10-phenanthroline	CD44	MESH:C025205	960	Chemical	Gene	inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|nmod|CD43 CD43|conj|END_ENTITY	Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes .
11027218	2	1,10-phenanthroline	600,619	CD45	425,429	1,10-phenanthroline	CD45	MESH:C025205	19264(Tax:10090)	Chemical	Gene	oxovanadate|dep|START_ENTITY co-treated|nmod|oxovanadate co-treated|advcl|investigate investigate|dobj|role role|nmod|END_ENTITY	To investigate the possible role of CD45 in microglial responsiveness to beta-amyloid -LRB- Abeta -RRB- peptides , we first co-treated primary cultured microglia with a tyrosine phosphatase inhibitor -LSB- potassium bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate -LRB- phen -RRB- , 5 micrometer -RSB- and freshly solubilized Abeta peptides -LRB- 1000 nm -RRB- .
20417561	6	1,10-phenanthroline	711,730	CD8	598,601	1,10-phenanthroline	CD8	MESH:C025205	925	Chemical	Gene	inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited Lck|nmod|interaction associate|nmod|Lck associate|nsubj|CD4 CD4|conj|END_ENTITY	CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline .
9331970	4	1,10-phenanthroline	524,543	CDO	455,458	1,10-phenanthroline	CDO	MESH:C025205	114106(Tax:10116)	Chemical	Gene	inactivated|advcl|START_ENTITY detected|conj|inactivated detected|nsubjpass|Activities Activities|conj|dioxygenase dioxygenase|appos|END_ENTITY	Activities of ADO and beta-carotene-15 ,15 ' - dioxygenase -LRB- CDO -RRB- were detected in the presence of thiols and were inactivated by 1,10-phenanthroline .
15893415	5	1,10-phenanthroline	732,751	CEA	641,644	1,10-phenanthroline	CEA	MESH:C025205	1084	Chemical	Gene	suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activated|nsubjpass|release release|compound|END_ENTITY	Furthermore , CEA release could be activated and inhibited by incubation of LS180 cells with suramin and 1,10-phenanthroline , compounds known to activate and inhibit GPI-PLD activity , respectively .
3342923	0	1,10-phenanthroline	28,47	ceruloplasmin	78,91	1,10-phenanthroline	ceruloplasmin	MESH:C025205	1356	Chemical	Gene	neocuproine|nummod|START_ENTITY Interaction|nmod|neocuproine Interaction|dep|dipyridyl dipyridyl|nmod|END_ENTITY	Interaction of neocuproine , 1,10-phenanthroline and 2,2 ' - dipyridyl with human ceruloplasmin .
8135553	6	1,10-phenanthroline	1383,1402	ceruloplasmin	1326,1339	1,10-phenanthroline	ceruloplasmin	MESH:C025205	1356	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|nsubj|degradation degradation|nmod|END_ENTITY	The degradation of ceruloplasmin by this fraction was inhibited by EDTA and 1,10-phenanthroline , indicating that a plasma metalloproteinase is responsible for degradation of ceruloplasmin .
8024692	7	1,10-phenanthroline	1366,1385	c-fos	1438,1443	1,10-phenanthroline	c-fos	MESH:C025205	2353	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|nmod|g33 g33|conj|END_ENTITY	At low concentrations -LRB- 5-200 microM -RRB- , 1,10-phenanthroline increased the expression of insulin-stimulated g33 , c-fos , and Egr-1 mRNA .
1330986	1	1,10-phenanthroline	227,246	Cl2	121,124	1,10-phenanthroline	Cl2	MESH:C025205	70762(Tax:10090)	Chemical	Gene	excess|nmod|START_ENTITY presence|nmod|excess sodium_borohydride|nmod|presence synthesized|nmod|sodium_borohydride synthesized|nsubjpass|END_ENTITY	-LSB- 99Tc -LRB- phen -RRB- 3 -RSB- Cl2 was synthesized by reduction of pertechnetate with sodium_borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry , magnetic susceptibility measurements , and i.r. / vis/u .
17095094	0	1,10-phenanthroline	100,119	Cl2	60,63	1,10-phenanthroline	Cl2	MESH:C025205	100862695	Chemical	Gene	bipyridine|conj|START_ENTITY complexes|dep|bipyridine complexes|amod|END_ENTITY	Variation of DNA photocleavage efficiency for -LSB- -LRB- TL -RRB- 2Ru -LRB- dpp -RRB- -RSB- Cl2 complexes where TL = 2,2 ' - bipyridine , 1,10-phenanthroline , or 4,7-diphenyl-1 ,10 - phenanthroline .
17585756	2	1,10-phenanthroline	326,345	Clip	390,394	1,10-phenanthroline	Clip	MESH:C025205	6249	Chemical	Gene	phen|ccomp|START_ENTITY geometries|dep|phen imposed|nmod|geometries changes|acl|imposed changes|dep|abbreviated abbreviated|nmod|END_ENTITY	Structural changes imposed on the coordination geometries of Cu -LRB- phen -RRB- -LRB- 2 -RRB- -LRB- +,2 + -RRB- -LRB- phen = 1,10-phenanthroline -RRB- linked by a serinol bridge -LRB- abbreviated as Clip -RRB- were studied , as well as their energetic profiles .
24442316	3	1,10-phenanthroline	599,618	CMCS	580,584	1,10-phenanthroline	CMCS	MESH:C025205	100036439(Tax:10090)	Chemical	Gene	treatment|conj|START_ENTITY groups|compound|treatment END_ENTITY|dobj|groups	39 male BABL/c mice were randomly divided into four groups : normal control , model control , CMCS treatment and 1,10-phenanthroline treatment groups .
12033328	7	1,10-phenanthroline	1106,1125	CO2	1168,1171	1,10-phenanthroline	CO2	MESH:C025205	717	Chemical	Gene	using|xcomp|START_ENTITY analysis|acl|using quenched|nsubj|analysis quenched|nmod|presence presence|nmod|END_ENTITY	In contrast , Cu -LRB- II -RRB- analysis using the CL reagent 1,10-phenanthroline is completely quenched in the presence of CO2 -LRB- aq -RRB- .
12033328	9	1,10-phenanthroline	1503,1522	CO4	1376,1379	1,10-phenanthroline	CO4	MESH:C025205	720	Chemical	Gene	luminol|conj|START_ENTITY enhance|advcl|luminol appears|xcomp|enhance implications|acl|appears has|dobj|implications has|nsubj|formation formation|dep|END_ENTITY	The formation of * CO4 - has very important analytical implications since this species appears to enhance or quench the CL signal from luminol and 1,10-phenanthroline , respectively .
9447964	9	1,10-phenanthroline	1444,1463	CPEB	1488,1492	1,10-phenanthroline	CPEB	MESH:C025205	734470(Tax:8355)	Chemical	Gene	ions|nmod|START_ENTITY Chelation|nmod|ions inhibits|nsubj|Chelation inhibits|dobj|ability ability|nmod|END_ENTITY	Chelation of metal ions by 1,10-phenanthroline inhibits the ability of CPEB to bind RNA ; however , RNA binding is restored if the reaction is supplemented with zinc .
27188502	2	1,10-phenanthroline	244,263	CsF	306,309	1,10-phenanthroline	CsF	MESH:C025205	1437	Chemical	Gene	2|conj|START_ENTITY acac|dep|2 showed|nsubj|acac showed|nmod|presence presence|nmod|END_ENTITY	Ni -LRB- acac -RRB- 2 and 1,10-phenanthroline showed the best result in the presence of CsF and CuF2 at 120 degC .
19319442	2	1,10-phenanthroline	201,220	CuX	177,180	1,10-phenanthroline	CuX	MESH:C025205	1523	Chemical	Gene	END_ENTITY|conj|START_ENTITY	In the presence of a small amount of CuX -LRB- X = Cl , Br , I -RRB- and 1,10-phenanthroline -LRB- phen -RRB- , the cross-coupling reactions of iodoarenes with trifluoromethylsilanes proceeded smoothly to afford trifluoromethylated aromatics in good yields .
19896525	1	1,10-phenanthroline	96,115	Cyp1a1	289,295	1,10-phenanthroline	Cyp1a1	MESH:C025205	1543	Chemical	Gene	phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|conj|decreased decreased|ccomp|-LSB- -LSB-|dobj|pyrene pyrene|dep|cytochrome_P450_1a1 cytochrome_P450_1a1|appos|END_ENTITY	1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level .
15242816	5	1,10-phenanthroline	773,792	CYP3A	851,856	1,10-phenanthroline	CYP3A	MESH:C025205	170509(Tax:10116)	Chemical	Gene	phenanthroline|amod|START_ENTITY use|nmod|phenanthroline decreased|nsubj|use decreased|dobj|stability stability|compound|END_ENTITY	The use of 1,10-phenanthroline -LRB- phenanthroline -RRB- , an inhibitor of PLD activity , decreased CYP3A stability in incubated microsomes .
20857437	7	1,10-phenanthroline	967,986	cytochrome_c	1073,1085	1,10-phenanthroline	cytochrome c	MESH:C025205	54205	Chemical	Gene	START_ENTITY|conj|digestion digestion|nmod|END_ENTITY	Using CF IR MALDESI , several chemical and biochemical reactions were monitored on-line : the chelation of 1,10-phenanthroline with iron -LRB- II -RRB- , insulin denaturation with 1,4-dithiothreitol , and tryptic digestion of cytochrome_c .
6773520	2	1,10-phenanthroline	253,272	cytochrome_P-450	354,370	1,10-phenanthroline	cytochrome P-450	MESH:C025205	100328948(Tax:9986)	Chemical	Gene	leads|amod|START_ENTITY salts|nmod|leads reaction|nmod|salts beta-naphthoflavone-inducible|nsubj|reaction beta-naphthoflavone-inducible|dobj|species species|amod|END_ENTITY	In liver microsomal membranes from adult rabbits treated with beta-naphthoflavone , reaction with Cu2 + salts plus 1,10-phenanthroline leads to the cross-linking of the two specifically beta-naphthoflavone-inducible cytochrome_P-450 species , form 4 and form 6 , to form homo - and hetero-dimer species .
19896525	0	1,10-phenanthroline	0,19	cytochrome_P450_1a1	75,94	1,10-phenanthroline	cytochrome P450 1a1	MESH:C025205	1543	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|nmod|enzyme enzyme|appos|END_ENTITY	1,10-phenanthroline stabilizes mRNA of the carcinogen-metabolizing enzyme , cytochrome_P450_1a1 .
19896525	1	1,10-phenanthroline	96,115	cytochrome_P450_1a1	268,287	1,10-phenanthroline	cytochrome P450 1a1	MESH:C025205	1543	Chemical	Gene	phen|amod|START_ENTITY inhibitors|nsubj|phen inhibitors|conj|decreased decreased|ccomp|-LSB- -LSB-|dobj|pyrene pyrene|dep|END_ENTITY	1,10-phenanthroline -LRB- phen -RRB- , flufenamic_acid , and indomethacin are inhibitors of aldo-keto_reductases_1C1 -LRB- AKR1C1 -RRB- , but only phen decreased the benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- - induced cytochrome_P450_1a1 -LRB- Cyp1a1 -RRB- protein level .
9173902	1	1,10-phenanthroline	489,508	DD1	258,261	1,10-phenanthroline	DD1	MESH:C025205	1645	Chemical	Gene	shows|nmod|START_ENTITY differ|parataxis|shows differ|nsubj|isoenzymes isoenzymes|appos|END_ENTITY	Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids .
9173902	1	1,10-phenanthroline	489,508	DD1	414,417	1,10-phenanthroline	DD1	MESH:C025205	1645	Chemical	Gene	shows|nmod|START_ENTITY shows|nsubj|END_ENTITY	Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids .
9173902	1	1,10-phenanthroline	489,508	DD2	266,269	1,10-phenanthroline	DD2	MESH:C025205	1646	Chemical	Gene	shows|nmod|START_ENTITY differ|parataxis|shows differ|nsubj|isoenzymes isoenzymes|appos|DD1 DD1|conj|END_ENTITY	Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids .
9173902	1	1,10-phenanthroline	489,508	DD2	518,521	1,10-phenanthroline	DD2	MESH:C025205	1646	Chemical	Gene	shows|nmod|START_ENTITY shows|advcl|oxidizes oxidizes|nsubj|END_ENTITY	Human liver dihydrodiol dehydrogenase isoenzymes -LRB- DD1 and DD2 -RRB- , in which only seven amino_acid residues are substituted , differ remarkably in specificity for steroidal substrates and inhibitor sensitivity : DD1 shows 20alpha-hydroxysteroid dehydrogenase activity and sensitivity to 1,10-phenanthroline , whereas DD2 oxidizes 3alpha-hydroxysteroids and is highly inhibited by bile_acids .
7061389	10	1,10-phenanthroline	1276,1295	dehydrogenase	1160,1173	1,10-phenanthroline	dehydrogenase	MESH:C025205	24791362	Chemical	Gene	alpha,alpha-dipyridyl|conj|START_ENTITY inhibited|xcomp|alpha,alpha-dipyridyl inhibited|nsubj|END_ENTITY	The purified formate dehydrogenase was strongly inhibited by cyanide -LRB- Ki = 6 microM -RRB- , azide -LRB- Ki = 39 microM -RRB- , alpha,alpha-dipyridyl , and 1,10-phenanthroline .
4206911	3	1,10-phenanthroline	219,238	diamine_oxidase	136,151	1,10-phenanthroline	diamine oxidase	MESH:C025205	26	Chemical	Gene	bipyridyl|amod|START_ENTITY reagents|dep|bipyridyl using|dobj|reagents studied|advcl|using studied|nsubjpass|inhibition inhibition|nmod|END_ENTITY	The inhibition of diamine_oxidase has been studied by using the following copper-chelating reagents : 1,10-phenanthroline ; 2,2 ' - bipyridyl ; 8-hydroxyquinoline -LRB- oxine -RRB- ; diethyldithiocarbamate and dithio-oxamide -LRB- rubeanic_acid -RRB- .
27924438	3	1,10-phenanthroline	806,825	dmb	864,867	1,10-phenanthroline	dmb	MESH:C025205	282491(Tax:9913)	Chemical	Gene	START_ENTITY|nmod:poss|END_ENTITY	The ancillary ligands 1,10-phenanthroline -LRB- phen -RRB- , 4,4 ' - Dimethyl-2 ,2 ' - dipyridyl -LRB- dmb -RRB- and 2,2 ' - dipyridine -LRB- bpy -RRB- having been discovered found to be involved in bond formation with the phosphate backbone of nucleotide base pairs in ruthenium -LRB- II -RRB- complex-DNA docked complex .
10661869	5	1,10-phenanthroline	874,893	DPP_III	834,841	1,10-phenanthroline	DPP III	MESH:C025205	114591(Tax:10116)	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubj|END_ENTITY	DPP_III was potently inhibited by EDTA , 1,10-phenanthroline , DFP , PCMBS and NEM .
10978617	6	1,10-phenanthroline	835,854	DPP_III	795,802	1,10-phenanthroline	DPP III	MESH:C025205	114591(Tax:10116)	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubj|END_ENTITY	DPP_III was potently inhibited by EDTA , 1,10-phenanthroline , DFP , PCMBS , NEM , beta-ME and iodoacetamide .
1633843	6	1,10-phenanthroline	1126,1145	DT	1043,1045	1,10-phenanthroline	DT	MESH:C025205	13190(Tax:10090)	Chemical	Gene	analogs|nmod|START_ENTITY presence|nmod|analogs assayed|nmod|presence assayed|nsubjpass|activity activity|compound|END_ENTITY	In addition , DT activity was assayed in the presence of two non-chelating structural analogs of 1,10-phenanthroline .
7547986	3	1,10-phenanthroline	501,520	DTNB	555,559	1,10-phenanthroline	DTNB	MESH:C025205	13528(Tax:10090)	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|conj|END_ENTITY	The dibasic cleaving enzyme was completely inhibited in the presence of 20-50 mM amine buffers , 0.1 mM EDTA , 0.5 mM 1,10-phenanthroline , 0.5 mM N-ethylmaleimide , and 1mM DTNB .
1992461	8	1,10-phenanthroline	1631,1650	ECE	1533,1536	1,10-phenanthroline	ECE	MESH:C025205	94204(Tax:10116)	Chemical	Gene	phosphoramidon|conj|START_ENTITY inhibitors|amod|phosphoramidon blocked|nmod|inhibitors identified|ccomp|blocked identified|nsubjpass|activity activity|compound|END_ENTITY	In a rabbit lung membrane preparation , ECE activity was identified that was blocked by the metalloprotease inhibitors phosphoramidon and 1,10-phenanthroline in a concentration-dependent manner .
20608701	2	1,10-phenanthroline	582,601	EDA	572,575	1,10-phenanthroline	EDA	MESH:C025205	1896	Chemical	Gene	carbon|amod|START_ENTITY Cu|conj|carbon Cu|appos|carbon carbon|dep|AC-CH AC-CH|xcomp|2 2|dep|END_ENTITY	Three nanoporous sorbents containing chelating diamine functionalities were evaluated for Cu -LRB- 2 + -RRB- adsorption from natural waters : ethylenediamine functionalized self-assembled monolayers on mesoporous supports -LRB- EDA-SAMMS -RRB- , ethylenediamine functionalized activated carbon -LRB- AC-CH -LRB- 2 -RRB- - EDA -RRB- , and 1,10-phenanthroline functionalized mesoporous carbon -LRB- Phen-FMC -RRB- .
9321921	6	1,10-phenanthroline	1707,1726	EGFR	1540,1544	1,10-phenanthroline	EGFR	MESH:C025205	13649(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY caused|conj|inhibited caused|nsubj|ligands ligands|amod|END_ENTITY	EGFR ligands caused upregulation of urokinase , urokinase receptor , and matrix metalloprotease-1 , and tubulogenesis could be inhibited by the metalloprotease inhibitor 1,10-phenanthroline .
20139904	4	1,10-phenanthroline	1155,1174	EGF-R	1234,1239	1,10-phenanthroline	EGF-R	MESH:C025205	1956	Chemical	Gene	AG1478|conj|START_ENTITY inhibited|nsubj|AG1478 inhibited|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	In addition , AG1478 , 1,10-phenanthroline , and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549 , HepG2 , and MDA-MB-231 cell lines .
8024692	7	1,10-phenanthroline	1366,1385	Egr-1	1449,1454	1,10-phenanthroline	Egr-1	MESH:C025205	1958	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|nmod|g33 g33|conj|mRNA mRNA|compound|END_ENTITY	At low concentrations -LRB- 5-200 microM -RRB- , 1,10-phenanthroline increased the expression of insulin-stimulated g33 , c-fos , and Egr-1 mRNA .
10556832	8	1,10-phenanthroline	1181,1200	elafin	1206,1212	1,10-phenanthroline	elafin	MESH:C025205	5266	Chemical	Gene	combination|nmod|START_ENTITY obtained|nmod|combination obtained|nmod|END_ENTITY	Maximal inhibition of sCR1 shedding was obtained by a combination of 1,10-phenanthroline with elafin -LRB- 86 + / - 6 % -RRB- .
8347898	11	1,10-phenanthroline	1657,1676	enkephalin	1720,1730	1,10-phenanthroline	enkephalin	MESH:C025205	29237(Tax:10116)	Chemical	Gene	capable|nsubj|START_ENTITY capable|advcl|inhibiting inhibiting|dobj|degradation degradation|compound|END_ENTITY	In addition , the chelator 1,10-phenanthroline was also capable of effectively inhibiting enkephalin degradation , suggesting that the enzyme responsible has the characteristics of a metalloprotease .
6808517	3	1,10-phenanthroline	542,561	Enkephalin_convertase	463,484	1,10-phenanthroline	Enkephalin convertase	MESH:C025205	1363	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA stimulated|conj|inhibited stimulated|nsubj|END_ENTITY	Enkephalin_convertase is markedly stimulated by CoCl2 and inhibited by EDTA or 1,10-phenanthroline , unlike the lysosomal carboxypeptidase .
2491751	4	1,10-phenanthroline	815,834	epidermal_growth_factor	744,767	1,10-phenanthroline	epidermal growth factor	MESH:C025205	1950	Chemical	Gene	agent|amod|START_ENTITY chelating|dobj|agent metal|acl|chelating mimicked|nmod|metal mimicked|nsubjpass|activity activity|nmod|END_ENTITY	The RBC cytolytic stimulating activity of epidermal_growth_factor could be mimicked by the metal chelating agent 1,10-phenanthroline , suggesting a possible role for calcium ions in the action of epidermal_growth_factor and proteases .
2491751	4	1,10-phenanthroline	815,834	epidermal_growth_factor	897,920	1,10-phenanthroline	epidermal growth factor	MESH:C025205	1950	Chemical	Gene	agent|amod|START_ENTITY chelating|dobj|agent chelating|advcl|suggesting suggesting|nmod|ions ions|nmod|action action|nmod|END_ENTITY	The RBC cytolytic stimulating activity of epidermal_growth_factor could be mimicked by the metal chelating agent 1,10-phenanthroline , suggesting a possible role for calcium ions in the action of epidermal_growth_factor and proteases .
11701758	7	1,10-phenanthroline	1002,1021	ERK	913,916	1,10-phenanthroline	ERK	MESH:C025205	26413(Tax:10090)	Chemical	Gene	U74500A|conj|START_ENTITY antioxidants|dep|U74500A treatment|nmod|antioxidants attenuated|nmod|treatment attenuated|nsubjpass|activation activation|compound|END_ENTITY	Surprisingly , ERK activation was not attenuated by concomitant treatment with antioxidants -LRB- U74500A or 1,10-phenanthroline -RRB- at concentrations that blocked ROS generation .
24885237	5	1,10-phenanthroline	1027,1046	ERK	1135,1138	1,10-phenanthroline	ERK	MESH:C025205	24338(Tax:10116)	Chemical	Gene	dismutase|conj|START_ENTITY dismutase|conj|nicotine nicotine|compound|END_ENTITY	After 3-4 days of IH , extracellular_signal-regulated_kinases_1 / 2 -LRB- ERK1/2 -RRB- protein phosphorylation decreased , which could be reversed by superoxide dismutase -LRB- SOD -RRB- , 1,10-phenanthroline -LRB- Phe -RRB- , the PP2A phosphorylation inhibitors , okadaic_acid -LRB- OKA -RRB- and cantharidin , and the ERK phosphorylation activator nicotine -LRB- p < 0.05 -RRB- .
20139904	4	1,10-phenanthroline	1155,1174	ERK1/2	1244,1250	1,10-phenanthroline	ERK1/2	MESH:C025205	5595;5594	Chemical	Gene	AG1478|conj|START_ENTITY inhibited|nsubj|AG1478 inhibited|dobj|phosphorylation phosphorylation|nmod|EGF-R EGF-R|conj|END_ENTITY	In addition , AG1478 , 1,10-phenanthroline , and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549 , HepG2 , and MDA-MB-231 cell lines .
24885237	5	1,10-phenanthroline	1027,1046	ERK1/2	929,935	1,10-phenanthroline	ERK1/2	MESH:C025205	50689;116590	Chemical	Gene	dismutase|conj|START_ENTITY reversed|nmod|dismutase decreased|ccomp|reversed decreased|nsubj|phosphorylation phosphorylation|amod|2 2|dep|END_ENTITY	After 3-4 days of IH , extracellular_signal-regulated_kinases_1 / 2 -LRB- ERK1/2 -RRB- protein phosphorylation decreased , which could be reversed by superoxide dismutase -LRB- SOD -RRB- , 1,10-phenanthroline -LRB- Phe -RRB- , the PP2A phosphorylation inhibitors , okadaic_acid -LRB- OKA -RRB- and cantharidin , and the ERK phosphorylation activator nicotine -LRB- p < 0.05 -RRB- .
15560890	8	1,10-phenanthroline	1076,1095	E-selectin	1154,1164	1,10-phenanthroline	E-selectin	MESH:C025205	6401	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|ICAM-1 ICAM-1|conj|END_ENTITY	In contrast , the non-antioxidant metal chelator 1,10-phenanthroline partially suppressed the surface expression of ICAM-1 and E-selectin .
7773548	7	1,10-phenanthroline	1141,1160	ET-1	1107,1111	1,10-phenanthroline	ET-1	MESH:C025205	24323(Tax:10116)	Chemical	Gene	prevented|nmod|START_ENTITY prevented|nsubjpass|degradation degradation|nmod|END_ENTITY	The degradation of ET-1 by recirc-K was prevented by 1,10-phenanthroline -LRB- 10 -LRB- -3 -RRB- M -RRB- , abolished by heating the recirc-K solution to 90 degrees C for 15 min , and reduced by EGTA -LRB- 5 x 10 -LRB- -3 -RRB- M -RRB- or ET-1 -LRB- 16-21 -RRB- -LRB- 10 -LRB- -5 -RRB- M -RRB- .
7773548	7	1,10-phenanthroline	1141,1160	ET-1	1282,1286	1,10-phenanthroline	ET-1	MESH:C025205	24323(Tax:10116)	Chemical	Gene	prevented|nmod|START_ENTITY prevented|conj|reduced reduced|nmod|EGTA EGTA|conj|END_ENTITY	The degradation of ET-1 by recirc-K was prevented by 1,10-phenanthroline -LRB- 10 -LRB- -3 -RRB- M -RRB- , abolished by heating the recirc-K solution to 90 degrees C for 15 min , and reduced by EGTA -LRB- 5 x 10 -LRB- -3 -RRB- M -RRB- or ET-1 -LRB- 16-21 -RRB- -LRB- 10 -LRB- -5 -RRB- M -RRB- .
1959454	1	1,10-phenanthroline	213,232	Fab	104,107	1,10-phenanthroline	Fab	MESH:C025205	2187	Chemical	Gene	modified|conj|START_ENTITY modified|nsubj|site site|nmod|fragment fragment|compound|END_ENTITY	The binding site of the Fab fragment of antibody MOPC315 was chemically modified with cyclam _ -LRB- 1,4,8,11-tetraazacyclotetradecane -RRB- and 1,10-phenanthroline .
15248789	1	1,10-phenanthroline	272,291	fac	207,210	1,10-phenanthroline	fac	MESH:C025205	2176	Chemical	Gene	reported|conj|START_ENTITY reported|nmod|series series|nmod|END_ENTITY	Photochemical and photophysical data are reported for a series of fac - -LSB- Mn -LRB- CO -RRB- -LRB- 3 -RRB- -LRB- phen -RRB- -LRB- Im-R -RRB- -RSB- -LRB- SO -LRB- 3 -RRB- CF -LRB- 3 -RRB- -RRB- complexes , where phen is 1,10-phenanthroline and Im is imidazole .
12175619	7	1,10-phenanthroline	1378,1397	fibrinogen	1175,1185	1,10-phenanthroline	fibrinogen	MESH:C025205	2244	Chemical	Gene	blocked|advcl|START_ENTITY event|acl|blocked gel|appos|event ran|nmod|gel fragments|acl:relcl|ran generating|dobj|fragments different|xcomp|generating different|advcl|incubated incubated|nsubjpass|END_ENTITY	In addition , when purified fibrinogen was incubated with L. intermedia abdominal extract , the fibrinogenolysis was completely different , generating low mass fragments that ran away from the gel , a proteolytic event not blocked by 1,10-phenanthroline .
15567466	5	1,10-phenanthroline	725,744	fibrinogen	658,668	1,10-phenanthroline	fibrinogen	MESH:C025205	2244	Chemical	Gene	inhibited|advcl|START_ENTITY able|conj|inhibited able|xcomp|cleave cleave|dobj|chains chains|nmod|END_ENTITY	SCE was able to cleave all chains of fibrinogen and fibrin and the cleavage was completely inhibited by 1,10-phenanthroline , suggesting an essential role for metalloprotease -LRB- s -RRB- in this process .
10504442	3	1,10-phenanthroline	472,491	fibronectin	632,643	1,10-phenanthroline	fibronectin	MESH:C025205	2335	Chemical	Gene	dermal-epidermal_separation|amod|START_ENTITY dermal-epidermal_separation|conj|disappearance disappearance|dep|region region|nmod|END_ENTITY	Tryptase caused , in the presence and absence of 1,10-phenanthroline , focal dermal-epidermal_separation above laminin and almost complete disappearance of the staining of the extra domain A region of cellular fibronectin in and beneath the basement membrane .
17535156	7	1,10-phenanthroline	1298,1317	fibronectin	1205,1216	1,10-phenanthroline	fibronectin	MESH:C025205	2335	Chemical	Gene	presence|nmod|START_ENTITY inhibited|nmod|presence resulted|parataxis|inhibited resulted|nmod|de-adhesion de-adhesion|conj|degradation degradation|nmod|END_ENTITY	LALP addition to endothelial cell cultures resulted in de-adhesion of the cells , and also in the degradation of fibronectin and fibrinogen -LRB- this could be inhibited by the presence of the bivalent chelator 1,10-phenanthroline -RRB- and of gelatin in vitro .
2549171	8	1,10-phenanthroline	1693,1712	fibronectin	1601,1612	1,10-phenanthroline	fibronectin	MESH:C025205	2335	Chemical	Gene	inhibitors|amod|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|degradation degradation|compound|END_ENTITY	In addition , formation of the rosette contact is insensitive to the ionophore monensin , and to inhibitors of proteolytic enzymes , while local fibronectin degradation at rosette contacts is inhibited by inhibitors of metalloproteases , 1,10-phenanthroline and NP-20 .
6325472	8	1,10-phenanthroline	1687,1706	fibronectin	1853,1864	1,10-phenanthroline	fibronectin	MESH:C025205	2335	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nmod|concentrations concentrations|acl:relcl|affect affect|advcl|supporting supporting|dobj|role role|nmod|proteases proteases|nmod|degradation degradation|nmod|substratum substratum|compound|END_ENTITY	However , both the release of radiolabeled peptides and the appearance of fluorescence-negative spots were inhibited by 1,10-phenanthroline at concentrations that did not affect cellular attachment and protein synthesis , thus supporting a role for proteases in localized degradation of fibronectin substratum .
8769737	5	1,10-phenanthroline	1272,1291	GAPDH	1330,1335	1,10-phenanthroline	GAPDH	MESH:C025205	100009074(Tax:9986)	Chemical	Gene	prevented|nsubj|START_ENTITY prevented|nmod|levels levels|amod|END_ENTITY	The cell.permeable iron chelator 1,10-phenanthroline completely prevented the increases in GAPDH mRNA levels induced by DDC .
26505793	0	1,10-phenanthroline	33,52	GLP-1	0,5	1,10-phenanthroline	GLP-1	MESH:C025205	2641	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|secretion secretion|compound|END_ENTITY	GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell .
26505793	4	1,10-phenanthroline	760,779	GLP-1	677,682	1,10-phenanthroline	GLP-1	MESH:C025205	2641	Chemical	Gene	secreted|nmod|START_ENTITY secreted|nsubjpass|hormone hormone|compound|END_ENTITY	We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- .
26505793	5	1,10-phenanthroline	1043,1062	GLP-1	1082,1087	1,10-phenanthroline	GLP-1	MESH:C025205	2641	Chemical	Gene	ligand|conj|START_ENTITY able|csubj|ligand able|xcomp|secrete secrete|dobj|hormone hormone|compound|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	5	1,10-phenanthroline	911,930	GLP-1	1082,1087	1,10-phenanthroline	GLP-1	MESH:C025205	2641	Chemical	Gene	used|dobj|START_ENTITY used|advcl|able able|xcomp|secrete secrete|dobj|hormone hormone|compound|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	6	1,10-phenanthroline	1282,1301	GLP-1	1185,1190	1,10-phenanthroline	GLP-1	MESH:C025205	2641	Chemical	Gene	secreted|nmod|START_ENTITY colocalized|conj|secreted colocalized|nsubjpass|hormone hormone|compound|END_ENTITY	Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells .
12110545	3	1,10-phenanthroline	606,625	GLUT4	548,553	1,10-phenanthroline	GLUT4	MESH:C025205	25139(Tax:10116)	Chemical	Gene	suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activated|nsubjpass|transfer transfer|compound|END_ENTITY	The in vitro GLUT4 transfer was activated and inhibited by suramin and 1,10-phenanthroline -LRB- an activator and an inhibitor of GPI-PLD activity , respectively -RRB- .
14522962	2	1,10-phenanthroline	274,293	glutaminyl_cyclase	140,158	1,10-phenanthroline	glutaminyl cyclase	MESH:C025205	25797	Chemical	Gene	chelators|amod|START_ENTITY suggested|nmod|chelators identified|advcl|suggested identified|nsubjpass|END_ENTITY	Human glutaminyl_cyclase -LRB- QC -RRB- was identified as a metalloenzyme as suggested by the time-dependent inhibition by the heterocyclic chelators 1,10-phenanthroline and dipicolinic_acid .
9180259	0	1,10-phenanthroline	39,58	glutathione_synthetase	13,35	1,10-phenanthroline	glutathione synthetase	MESH:C025205	14854(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of glutathione_synthetase by 1,10-phenanthroline .
8658562	6	1,10-phenanthroline	1121,1140	glyceraldehyde-3-phosphate_dehydrogenase	1064,1104	1,10-phenanthroline	glyceraldehyde-3-phosphate dehydrogenase	MESH:C025205	108351137	Chemical	Gene	activated|advcl|START_ENTITY activated|nsubjpass|END_ENTITY	The purified cytosolic enzymes lactate dehydrogenase and glycerol-3-phosphate_dehydrogenase are inhibited while purified glyceraldehyde-3-phosphate_dehydrogenase is activated by 1,10-phenanthroline .
8658562	6	1,10-phenanthroline	1121,1140	glycerol-3-phosphate_dehydrogenase	1000,1034	1,10-phenanthroline	glycerol-3-phosphate dehydrogenase	MESH:C025205	60666(Tax:10116)	Chemical	Gene	activated|advcl|START_ENTITY inhibited|advcl|activated inhibited|nsubj|lactate lactate|amod|dehydrogenase dehydrogenase|conj|END_ENTITY	The purified cytosolic enzymes lactate dehydrogenase and glycerol-3-phosphate_dehydrogenase are inhibited while purified glyceraldehyde-3-phosphate_dehydrogenase is activated by 1,10-phenanthroline .
15146242	4	1,10-phenanthroline	841,860	GM6001	786,792	1,10-phenanthroline	GM6001	MESH:C025205	546949(Tax:10090)	Chemical	Gene	chelator|dep|START_ENTITY injection|conj|chelator injection|nmod|END_ENTITY	Gelatinolytic activity was detected earliest within the matrix of cortical blood vessels and later within neurons and pia arachnoid -LRB- > or = 3 hours -RRB- , particularly within piriform cortex ; this activity was suppressed by injection of the metalloprotease inhibitor GM6001 or in vitro by the addition of a zinc chelator -LRB- 1,10-phenanthroline -RRB- .
14611645	9	1,10-phenanthroline	1537,1556	GPI-PLD	1560,1567	1,10-phenanthroline	GPI-PLD	MESH:C025205	2822	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Furthermore , 1,10-phenanthroline , a GPI-PLD inhibitor , reversed this effect .
15893415	5	1,10-phenanthroline	732,751	GPI-PLD	793,800	1,10-phenanthroline	GPI-PLD	MESH:C025205	2822	Chemical	Gene	suramin|conj|START_ENTITY inhibited|nmod|suramin activated|conj|inhibited activate|parataxis|activated activate|dobj|activity activity|amod|END_ENTITY	Furthermore , CEA release could be activated and inhibited by incubation of LS180 cells with suramin and 1,10-phenanthroline , compounds known to activate and inhibit GPI-PLD activity , respectively .
17467053	7	1,10-phenanthroline	1127,1146	GPI-PLD	1164,1171	1,10-phenanthroline	GPI-PLD	MESH:C025205	2822	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment .
7512501	6	1,10-phenanthroline	1118,1137	GPI-PLD	1155,1162	1,10-phenanthroline	GPI-PLD	MESH:C025205	2822	Chemical	Gene	cells|nmod|START_ENTITY Treatment|nmod|cells Treatment|appos|inhibitor inhibitor|nmod|END_ENTITY	Treatment of HeLa cells with 1,10-phenanthroline , an inhibitor of GPI-PLD , reduced the release of -LSB- 3H -RSB- ethanolamine-DAF by 70 % .
10807918	6	1,10-phenanthroline	1312,1331	HB-EGF	1151,1157	1,10-phenanthroline	HB-EGF	MESH:C025205	1839	Chemical	Gene	-RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nmod|mechanism mechanism|nmod|release release|nmod|heparin-binding_EGF heparin-binding_EGF|appos|END_ENTITY	Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline .
10807918	6	1,10-phenanthroline	1312,1331	HB-EGF	1270,1276	1,10-phenanthroline	HB-EGF	MESH:C025205	1839	Chemical	Gene	-RSB-|conj|START_ENTITY -RSB-|conj|inhibitor inhibitor|nmod|END_ENTITY	Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline .
10807918	6	1,10-phenanthroline	1312,1331	heparin-binding_EGF	1130,1149	1,10-phenanthroline	heparin-binding EGF	MESH:C025205	1839	Chemical	Gene	-RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nmod|mechanism mechanism|nmod|release release|nmod|END_ENTITY	Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline .
16503297	4	1,10-phenanthroline	467,486	Hg2	458,461	1,10-phenanthroline	Hg2	MESH:C025205	283955	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|conj|+ +|advmod|END_ENTITY	The purified enzyme had a molecular mass of 55 kDa and a pI 5.8 , and the hydrolase activity was strongly inhibited by EDTA , dithiothreitol -LRB- DTT -RRB- , Hg2 + and 1,10-phenanthroline .
17190448	7	1,10-phenanthroline	1242,1261	HIF-1	1271,1276	1,10-phenanthroline	HIF-1	MESH:C025205	3091	Chemical	Gene	chelator|dep|START_ENTITY chelator|conj|activation activation|compound|END_ENTITY	Sodwanone V -LRB- 8 -RRB- inhibited both hypoxia-induced and iron chelator -LRB- 1,10-phenanthroline -RRB- - induced HIF-1 activation in T47D breast_tumor cells -LRB- IC50 15 microM -RRB- , and 8 was the only sodwanone that inhibited HIF-1 activation in PC-3 prostate_tumor cells -LRB- IC50 15 microM -RRB- .
18586877	13	1,10-phenanthroline	1315,1334	HIF-1alpha	1364,1374	1,10-phenanthroline	HIF-1alpha	MESH:C025205	15251(Tax:10090)	Chemical	Gene	chelator|appos|START_ENTITY injection|nmod|chelator prevented|nsubj|injection prevented|dobj|degradation degradation|nmod|END_ENTITY	Systemic injection of the iron chelator , 1,10-phenanthroline prevented the degradation of HIF-1alpha and reduced oxygen-induced proliferation .
10360838	8	1,10-phenanthroline	1016,1035	HMP1	992,996	1,10-phenanthroline	HMP1	MESH:C025205	10531	Chemical	Gene	inactivated|nmod|START_ENTITY inactivated|nsubjpass|END_ENTITY	HMP1 was inactivated by 1,10-phenanthroline , a specific inhibitor of Zn -LRB- +2 -RRB- - dependent metalloproteases .
20888885	4	1,10-phenanthroline	864,883	HO-1	749,753	1,10-phenanthroline	HO-1	MESH:C025205	15368(Tax:10090)	Chemical	Gene	SO|amod|START_ENTITY scavengers|nmod|SO suppressed|nmod|scavengers suppressed|nsubjpass|expression expression|compound|END_ENTITY	Interestingly , the raloxifene-induced HO-1 expression was suppressed by reactive oxygen species -LRB- ROS -RRB- scavengers , including glutathione , TEMPO , Me -LRB- 2 -RRB- SO , 1,10-phenanthroline , or allopurinol .
1938939	4	1,10-phenanthroline	599,618	HSC82	792,797	1,10-phenanthroline	HSC82	MESH:C025205	855224(Tax:4932)	Chemical	Gene	intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|END_ENTITY	Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- .
1938939	4	1,10-phenanthroline	599,618	HSP26	805,810	1,10-phenanthroline	HSP26	MESH:C025205	852364(Tax:4932)	Chemical	Gene	intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|HSC82 HSC82|dep|END_ENTITY	Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- .
8530397	2	1,10-phenanthroline	357,376	HSP_70	346,352	1,10-phenanthroline	HSP 70	MESH:C025205	3308	Chemical	Gene	synthesis|amod|START_ENTITY studied|nmod|synthesis studied|parataxis|homolog homolog|nmod|END_ENTITY	This investigation studied the pharmacological induction of HSP 68 -LRB- HSP 68 is the rat homolog of human HSP_70 -RRB- by 1,10-phenanthroline in cultured rat astrocytes under conditions that activated heat_shock transcription factor-1 without inducing HSP 68 synthesis .
10069381	3	1,10-phenanthroline	386,405	hsp72	419,424	1,10-phenanthroline	hsp72	MESH:C025205	3303	Chemical	Gene	pyrrolidine_dithiocarbamate|conj|START_ENTITY induction|amod|pyrrolidine_dithiocarbamate induction|nmod|END_ENTITY	In the presence of the antioxidant molecules pyrrolidine_dithiocarbamate or 1,10-phenanthroline induction of hsp72 and 27 was significantly decreased , while N-acetyl-L-cysteine caused a slight reduction .
1938939	4	1,10-phenanthroline	599,618	HSP82	750,755	1,10-phenanthroline	HSP82	MESH:C025205	855836(Tax:4932)	Chemical	Gene	intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|END_ENTITY	Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- .
15560890	8	1,10-phenanthroline	1076,1095	ICAM-1	1143,1149	1,10-phenanthroline	ICAM-1	MESH:C025205	3383	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|dobj|expression expression|nmod|END_ENTITY	In contrast , the non-antioxidant metal chelator 1,10-phenanthroline partially suppressed the surface expression of ICAM-1 and E-selectin .
7494830	4	1,10-phenanthroline	638,657	IDE	604,607	1,10-phenanthroline	IDE	MESH:C025205	3416	Chemical	Gene	N-ethylmaleimide|dep|START_ENTITY inhibitors|appos|N-ethylmaleimide inhibitors|compound|END_ENTITY	Cytosolic insulin-degrading activity had a pH optimum of 7.5 , was almost completely inhibited by IDE inhibitors -LRB- N-ethylmaleimide , 1,10-phenanthroline , EDTA , p-chloromercuribenzoate , bacitracin -RRB- , but was not or only weakly inhibited by others -LRB- aprotinin , chymostatin , leupeptin , and diisopropyl_phosphofluoridate . -RRB-
7596985	4	1,10-phenanthroline	637,656	IDE	593,596	1,10-phenanthroline	IDE	MESH:C025205	3416	Chemical	Gene	N-ethylmaleimide|conj|START_ENTITY inhibitors|nmod|N-ethylmaleimide inhibitors|compound|END_ENTITY	Cytosolic insulin degradation was strongly inhibited by IDE inhibitors , including N-ethylmaleimide , 1,10-phenanthroline , p-chloromericuribenzoate , and EDTA , but was not significantly or not as extensively inhibited by strong inhibitors of proteasome , i.e. , chymostatin , soybean trypsin inhibitor , leupeptin , and Dip-F .
7789307	7	1,10-phenanthroline	1224,1243	IDE	1191,1194	1,10-phenanthroline	IDE	MESH:C025205	3416	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nsubjpass|activity activity|amod|insulin-degrading_enzyme insulin-degrading_enzyme|dep|END_ENTITY	When cytoplasmic insulin-degrading_enzyme -LRB- IDE -RRB- activity was inhibited with 1,10-phenanthroline , an increase in the number of cytoplasmic and nuclear Nanogold-insulin particles was observed .
8504733	5	1,10-phenanthroline	816,835	IDE	806,809	1,10-phenanthroline	IDE	MESH:C025205	25700(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY insulin_degrading_enzyme|nmod|cells insulin_degrading_enzyme|appos|END_ENTITY	We examined the effects of inhibiting insulin_degrading_enzyme -LRB- IDE -RRB- with 1,10-phenanthroline on the nuclear accumulation of insulin in H35 cells .
10807918	6	1,10-phenanthroline	1312,1331	IGF-1	1009,1014	1,10-phenanthroline	IGF-1	MESH:C025205	3479	Chemical	Gene	-RSB-|conj|START_ENTITY inhibited|nmod|-RSB- mediated|advcl|inhibited mediated|nsubjpass|talk talk|nmod|receptors receptors|compound|END_ENTITY	Cross talk between IGF-1 and EGF receptors is mediated through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-binding_EGF -LRB- HB-EGF -RRB- , because IGF-1-mediated ERK activation is inhibited both by -LSB- Glu -LRB- 52 -RRB- -RSB- Diphtheria toxin , a specific inhibitor of HB-EGF , and the metalloprotease inhibitor 1,10-phenanthroline .
15013428	4	1,10-phenanthroline	779,798	IGFBP-3	674,681	1,10-phenanthroline	IGFBP-3	MESH:C025205	3486	Chemical	Gene	EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|dobj|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
11768717	7	1,10-phenanthroline	1198,1217	IGFBP-4	1152,1159	1,10-phenanthroline	IGFBP-4	MESH:C025205	360622(Tax:10116)	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|nsubj|proteolysis proteolysis|compound|END_ENTITY	IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I .
11867336	6	1,10-phenanthroline	1456,1475	IGFBP-4	1166,1173	1,10-phenanthroline	IGFBP-4	MESH:C025205	360622(Tax:10116)	Chemical	Gene	inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance collected|advcl|showed CM|acl|collected examined|nmod|CM examined|nsubjpass|proteolysis proteolysis|compound|END_ENTITY	IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline .
11867336	6	1,10-phenanthroline	1456,1475	IGFBP-4	1416,1423	1,10-phenanthroline	IGFBP-4	MESH:C025205	360622(Tax:10116)	Chemical	Gene	inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited abundance|compound|END_ENTITY	IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline .
7531715	10	1,10-phenanthroline	2053,2072	IGFBP-4	1836,1843	1,10-phenanthroline	IGFBP-4	MESH:C025205	3487	Chemical	Gene	prevented|xcomp|START_ENTITY time|conj|prevented time|nmod|levels levels|compound|END_ENTITY	The effects of IGFs on IGFBP-4 levels in this cell-free system were time , temperature , and pH dependent and were prevented by the serine proteinase inhibitor , aprotinin , by the divalent cation chelator , EDTA , and by the metal ion chelator , 1,10-phenanthroline .
11768717	7	1,10-phenanthroline	1198,1217	IGF-I	1257,1262	1,10-phenanthroline	IGF-I	MESH:C025205	24482(Tax:10116)	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|nmod|END_ENTITY	IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I .
11768717	7	1,10-phenanthroline	1198,1217	IGF-I	1310,1315	1,10-phenanthroline	IGF-I	MESH:C025205	24482(Tax:10116)	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|conj|END_ENTITY	IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I .
15013428	4	1,10-phenanthroline	779,798	IGF-I	719,724	1,10-phenanthroline	IGF-I	MESH:C025205	3479	Chemical	Gene	EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|nmod|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
11768717	7	1,10-phenanthroline	1198,1217	IGF-II	1267,1273	1,10-phenanthroline	IGF-II	MESH:C025205	24483(Tax:10116)	Chemical	Gene	inhibited|conj|START_ENTITY inhibited|conj|accentuated accentuated|nmod|addition addition|nmod|IGF-I IGF-I|conj|END_ENTITY	IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and , to a lesser extent , by des -LRB- 1-3 -RRB- IGF-I .
15013428	4	1,10-phenanthroline	779,798	IGF-II	728,734	1,10-phenanthroline	IGF-II	MESH:C025205	3481	Chemical	Gene	EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|nmod|IGF-I IGF-I|conj|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
17048265	0	1,10-phenanthroline	134,153	III	48,51	1,10-phenanthroline	III	MESH:C025205	4514	Chemical	Gene	bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|shifts shifts|nmod|gold gold|appos|END_ENTITY	1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline .
17048265	0	1,10-phenanthroline	134,153	III	61,64	1,10-phenanthroline	III	MESH:C025205	4514	Chemical	Gene	bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|cobalt cobalt|appos|END_ENTITY	1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline .
17048265	0	1,10-phenanthroline	134,153	III	75,78	1,10-phenanthroline	III	MESH:C025205	4514	Chemical	Gene	bipyridine|conj|START_ENTITY -|amod|bipyridine 1H|appos|- 1H|appos|cobalt cobalt|appos|rhodium rhodium|appos|END_ENTITY	1H , 13C and 15N NMR coordination shifts in gold -LRB- III -RRB- , cobalt -LRB- III -RRB- , rhodium -LRB- III -RRB- _ chloride complexes with pyridine , 2,2 ' - bipyridine and 1,10-phenanthroline .
11867336	6	1,10-phenanthroline	1456,1475	IL-1beta	1303,1311	1,10-phenanthroline	IL-1beta	MESH:C025205	24494(Tax:10116)	Chemical	Gene	inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance showed|nsubj|incubation incubation|nmod|medium medium|conj|END_ENTITY	IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline .
10341317	13	1,10-phenanthroline	1447,1466	IL-4R	1510,1515	1,10-phenanthroline	IL-4R	MESH:C025205	3566	Chemical	Gene	dose-dependently|amod|START_ENTITY Phosphoramidon|conj|dose-dependently inhibited|nsubj|Phosphoramidon inhibited|xcomp|shedding shedding|advcl|END_ENTITY	Phosphoramidon and 1,10-phenanthroline dose-dependently inhibited shedding of the IL-4R , even in nonactivated T cells .
9376127	5	1,10-phenanthroline	775,794	IL-5	753,757	1,10-phenanthroline	IL-5	MESH:C025205	3567	Chemical	Gene	chymostatin|amod|START_ENTITY inhibited|nmod|chymostatin inhibited|nsubjpass|transmigration transmigration|nmod|eosinophils eosinophils|acl|induced induced|nmod|PAF PAF|conj|END_ENTITY	Matrigel transmigration of eosinophils induced by PAF and IL-5 was inhibited by 1,10-phenanthroline , batimastat , 3,4-dichloroisocoumarin , chymostatin , and a neutralizing antibody for the matrix_metalloproteinase _ -LRB- MMP -RRB- -9 , indicating that serine proteinase -LRB- s -RRB- and MMP , specifically MMP-9 , were involved in the transmigration of eosinophils through Matrigel .
8024692	2	1,10-phenanthroline	467,486	insulin	566,573	1,10-phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	enzyme|nmod|START_ENTITY inhibition|nmod|enzyme caused|nsubj|inhibition caused|nmod|accumulation accumulation|nmod|END_ENTITY	In a recent study , inhibition of insulin-degrading enzyme with 1,10-phenanthroline , a Zn2 + chelator , caused a significant increase in the nuclear accumulation of insulin .
8024692	3	1,10-phenanthroline	622,641	insulin	694,701	1,10-phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|conj|isomer isomer|nmod|degradation degradation|compound|END_ENTITY	The present study characterized the effects of 1,10-phenanthroline and its nonchelating isomer , 1,7-phenanthroline , on insulin degradation , nuclear accumulation , and stimulation of immediate-early gene expression .
8024692	6	1,10-phenanthroline	1161,1180	insulin	1120,1127	1,10-phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	tested|nsubj|START_ENTITY revealed|ccomp|tested revealed|nmod|presence presence|nmod|END_ENTITY	In the presence of insulin , Northern analysis revealed that 1,10-phenanthroline at all concentrations tested increased alpha-tubulin mRNA levels , but had a biphasic effect on insulin-stimulated immediate-early gene expression .
8504733	5	1,10-phenanthroline	816,835	insulin_degrading_enzyme	780,804	1,10-phenanthroline	insulin degrading enzyme	MESH:C025205	25700(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	We examined the effects of inhibiting insulin_degrading_enzyme -LRB- IDE -RRB- with 1,10-phenanthroline on the nuclear accumulation of insulin in H35 cells .
7789307	7	1,10-phenanthroline	1224,1243	insulin-degrading_enzyme	1165,1189	1,10-phenanthroline	insulin-degrading enzyme	MESH:C025205	3416	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nsubjpass|activity activity|amod|END_ENTITY	When cytoplasmic insulin-degrading_enzyme -LRB- IDE -RRB- activity was inhibited with 1,10-phenanthroline , an increase in the number of cytoplasmic and nuclear Nanogold-insulin particles was observed .
8953512	3	1,10-phenanthroline	573,592	insulin-degrading_enzyme	519,543	1,10-phenanthroline	insulin-degrading enzyme	MESH:C025205	25700(Tax:10116)	Chemical	Gene	N-ethylmaleimide|amod|START_ENTITY inhibit|nmod|N-ethylmaleimide inhibit|xcomp|END_ENTITY	Inhibitors that inhibit insulin-degrading_enzyme , including N-ethylmaleimide , 1,10-phenanthroline and p-chloromercuribenzoate , dramatically improved insulin transport across the ileum .
15013428	4	1,10-phenanthroline	779,798	insulin-like_growth_factor_binding_protein-3	628,672	1,10-phenanthroline	insulin-like growth factor binding protein-3	MESH:C025205	3486	Chemical	Gene	EDTA|conj|START_ENTITY prevented|advcl|EDTA digested|conj|prevented digested|dobj|IGFBP-3 IGFBP-3|amod|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
24136115	8	1,10-phenanthroline	1542,1561	JAK_2	1570,1575	1,10-phenanthroline	JAK 2	MESH:C025205	3717	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|inhibitor inhibitor|compound|END_ENTITY	The MMP-2 platelet activation pathway can be synergistically inhibited with the non-selective MMP inhibitor , 1,10-phenanthroline , plus a JAK_2 inhibitor .
17680773	9	1,10-phenanthroline	1673,1692	JNK	1750,1753	1,10-phenanthroline	JNK	MESH:C025205	5599	Chemical	Gene	CQ|conj|START_ENTITY -LSB-|dobj|CQ inhibited|ccomp|-LSB- ligands|acl:relcl|inhibited induced|nsubj|ligands induced|dobj|activation activation|nmod|PI3K PI3K|conj|END_ENTITY	Metal ligands that inhibited Abeta levels -LSB- e.g. CQ , 8HQ , NC -LRB- neocuproine -RRB- , 1,10-phenanthroline and PDTC -RSB- induced metal-dependent activation of PI3K and JNK , resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta .
7594568	6	1,10-phenanthroline	853,872	KIR	1053,1056	1,10-phenanthroline	KIR	MESH:C025205	3805	Chemical	Gene	chelator|amod|START_ENTITY addition|nmod|chelator reversed|nsubj|addition reversed|advcl|demonstrating demonstrating|ccomp|necessary necessary|nmod|function function|nmod|END_ENTITY	Furthermore , addition of the zinc chelator 1,10-phenanthroline during chromium release assays reversed the inhibition of killing by NK clones specific for HLA-Cw4 or HLA-Cw8 , demonstrating that zinc is necessary for the inhibitory function of KIR .
12568801	6	1,10-phenanthroline	1121,1140	LAP	959,962	1,10-phenanthroline	LAP	MESH:C025205	51056	Chemical	Gene	metals|conj|START_ENTITY inhibited|nsubj|metals C.|acl:relcl|inhibited active|dep|C. active|advcl|C C|nsubj|temperature temperature|nmod|activity activity|compound|END_ENTITY	Although the optimal temperature of LAP activity was 40 degrees C , the enzyme was active over a broad temperature range from 2 to 60 degrees C. Among a number of inhibitors tested , heavy metals and 1,10-phenanthroline completely inhibited the enzyme , while methanol , ethanol and EGTA stimulated somewhat LAP activity .
18155948	4	1,10-phenanthroline	627,646	LAP	741,744	1,10-phenanthroline	LAP	MESH:C025205	51056	Chemical	Gene	START_ENTITY|advcl|END_ENTITY	Among a number of inhibitors tested , the most efficient were 1,10-phenanthroline having a K -LRB- i -RRB- value of 0.12 mM and cysteine with K -LRB- i -RRB- value of 0.31 mM , while EGTA stimulated LAP activity .
20417561	6	1,10-phenanthroline	711,730	Lck	617,620	1,10-phenanthroline	Lck	MESH:C025205	3932	Chemical	Gene	inhibited|xcomp|START_ENTITY interaction|acl:relcl|inhibited END_ENTITY|nmod|interaction	CD4 and CD8 associate with Lck via a zinc-dependent interaction that is inhibited by the divalent metal cation chelator , 1,10-phenanthroline .
20417561	7	1,10-phenanthroline	826,845	Lck	873,876	1,10-phenanthroline	Lck	MESH:C025205	3932	Chemical	Gene	presence|nmod|START_ENTITY abolished|nmod|presence show|ccomp|abolished show|conj|reduced reduced|nsubj|association association|nmod|END_ENTITY	Here we show that both CD4 and CD44-mediated T cell spreading is abolished in the presence of 1,10-phenanthroline and their association with Lck is significantly reduced .
2244921	4	1,10-phenanthroline	674,693	leukotriene_A4_hydrolase	614,638	1,10-phenanthroline	leukotriene A4 hydrolase	MESH:C025205	4048	Chemical	Gene	removed|nmod|START_ENTITY removed|nsubjpass|atom atom|nmod|END_ENTITY	The zinc atom of leukotriene_A4_hydrolase can be removed by dialysis against 1,10-phenanthroline which results in loss of enzyme activity .
3519317	1	1,10-phenanthroline	568,587	LHRH	613,617	1,10-phenanthroline	LHRH	MESH:C025205	25194(Tax:10116)	Chemical	Gene	reagents|conj|START_ENTITY reagents|conj|analogues analogues|compound|END_ENTITY	The peptidase was inhibited by sulphydryl reagents , TLCK , 1,10-phenanthroline , EDTA , bacitracin , other LHRH analogues , oxytocin , -LSB- Lys8 -RSB- vasopressin and somatostatin .
7507963	4	1,10-phenanthroline	395,414	L-selectin	628,638	1,10-phenanthroline	L-selectin	MESH:C025205	6402	Chemical	Gene	inhibitable|advcl|START_ENTITY inhibitable|amod|inhibitable involved|nsubjpass|inhibitable involved|nmod|cleavage cleavage|conj|cleavage cleavage|nmod|END_ENTITY	Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes .
15034049	6	1,10-phenanthroline	1098,1117	MASP-3	1197,1203	1,10-phenanthroline	MASP-3	MESH:C025205	5648	Chemical	Gene	iodoacetamide|conj|START_ENTITY inhibitors|amod|iodoacetamide presence|nmod|inhibitors prevented|nmod|presence prevented|conj|abolished abolished|nmod|Ser Ser|nmod|END_ENTITY	Activation was prevented in the presence of protease inhibitors iodoacetamide and 1,10-phenanthroline but was not abolished upon substitution of Ala for the active site Ser -LRB- 645 -RRB- of MASP-3 , indicating extrinsic proteolysis .
9267436	2	1,10-phenanthroline	511,530	Mbr1p	318,323	1,10-phenanthroline	Mbr1p	MESH:C025205	853769(Tax:4932)	Chemical	Gene	presence|nmod|START_ENTITY conditions|conj|presence factor|nmod|conditions factor|nsubj|END_ENTITY	In this paper , we show that Mbr1p is a limiting factor for growth on glycerol medium under the following sub-optimal culture conditions : in late growth phase , at low temperature , at high external pH or in the presence of 1,10-phenanthroline .
14575869	6	1,10-phenanthroline	1058,1077	MEK	1108,1111	1,10-phenanthroline	MEK	MESH:C025205	5609	Chemical	Gene	MAPK|nmod|START_ENTITY phosphorylation|nmod|MAPK depends|nsubj|phosphorylation depends|nmod|interaction interaction|nmod|END_ENTITY	Our results suggest that phosphorylation of MAPK by 1,10-phenanthroline depends on the interaction of MEK .
1335413	4	1,10-phenanthroline	1056,1075	metalloendopeptidase	1168,1188	1,10-phenanthroline	metalloendopeptidase	MESH:C025205	64517(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY suggests|nsubj|inhibition suggests|dobj|contribution contribution|nmod|one one|amod|END_ENTITY	Its inhibition by 1,10-phenanthroline , EDTA and bacitracin but not by thiorphan suggests the contribution of at least one neutral metalloendopeptidase , distinct from EC 3.4.24.11 , for which ANP showed high affinity .
9882532	9	1,10-phenanthroline	1651,1670	metalloproteinase	1695,1712	1,10-phenanthroline	metalloproteinase	MESH:C025205	547880(Tax:3847)	Chemical	Gene	START_ENTITY|conj|END_ENTITY	Similarly , incubating injured tissues in either 1,10-phenanthroline or phosphoramidon , both metalloproteinase inhibitors , did not prevent endothelial cell movement nor wound repair .
9344851	6	1,10-phenanthroline	924,943	mGPDH	799,804	1,10-phenanthroline	mGPDH	MESH:C025205	14571(Tax:10090)	Chemical	Gene	inhibited|conj|START_ENTITY was|advmod|inhibited was|nsubj|activation activation|nmod|END_ENTITY	The AA activation of mGPDH was likewise completely inhibited by iron specific chelators , bathophenanthrolinedisulfonic_acid , desferrioxamine , and 1,10-phenanthroline , but the activation could not be restored by the addition of excess Ca2 + .
16814470	4	1,10-phenanthroline	705,724	MMP	690,693	1,10-phenanthroline	MMP	MESH:C025205	100194417(Tax:3847)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	The conditioned media from cell-mediated collagen degradation assays were incubated with Type I collagen at pH 7.5 with or without a MMP inhibitor -LRB- 1,10-phenanthroline -RRB- , serine proteinase inhibitors -LRB- alpha1-antitrypsin and soybean trypsin inhibitor , STI -RRB- , or cysteine proteinase inhibitors .
19136476	10	1,10-phenanthroline	1540,1559	MMP-1	1443,1448	1,10-phenanthroline	MMP-1	MESH:C025205	4312	Chemical	Gene	blocked|parataxis|START_ENTITY blocked|nsubjpass|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	15d-PGJ2-mediated upregulation of MMP-1 expression was blocked by the iron chelator desferrioxamine and the Fe2 + - specific chelator 1,10-phenanthroline .
24136115	4	1,10-phenanthroline	710,729	MMP-1	751,756	1,10-phenanthroline	MMP-1	MESH:C025205	4312	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	In vitro analysis demonstrated that 1,10-phenanthroline completely inhibited MMP-1 ,2 , and 9 but had little to no effect on calpain activity while the converse was true with AEBSF .
8045973	5	1,10-phenanthroline	974,993	MMP-1	796,801	1,10-phenanthroline	MMP-1	MESH:C025205	4312	Chemical	Gene	confirmed|conj|START_ENTITY confirmed|nsubj|Identities Identities|nmod|END_ENTITY	Identities of MMP-1 and MMP-3 were confirmed by Western blots , by comparison of mol wt with those of purified enzymes on casein zymography , and by inhibition of these activities with EDTA and 1,10-phenanthroline .
12047435	9	1,10-phenanthroline	1301,1320	MMP-2	1402,1407	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	attenuated|nsubj|START_ENTITY attenuated|advcl|increased increased|nsubj|addition addition|nmod|exogenous exogenous|acl|purified purified|xcomp|END_ENTITY	The MMP inhibitor 1,10-phenanthroline attenuated the increased proliferation , while the addition of exogenous purified MMP-2 alone also increased fibroblast proliferation .
14732714	10	1,10-phenanthroline	1804,1823	MMP-2	1677,1682	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	-1|conj|START_ENTITY inhibited|nmod|-1 inhibited|nsubjpass|M392L M392L|amod|END_ENTITY	-LRB- M392L -RRB- MMP-2 and -LRB- M392S -RRB- MMP-2 were inhibited by tissue_inhibitor_of_metalloproteinases _ -LRB- TIMP -RRB- -1 , _ -2 , _ and _ -4 and by the zinc chelators 1,10-phenanthroline and a synthetic hydroxamate inhibitor , Batimastat , similar to the wild-type protein , indicating an unaltered active site topography .
14732714	10	1,10-phenanthroline	1804,1823	MMP-2	1694,1699	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	-1|conj|START_ENTITY inhibited|nmod|-1 inhibited|nsubjpass|M392L M392L|amod|MMP-2 END_ENTITY|conj|MMP-2	-LRB- M392L -RRB- MMP-2 and -LRB- M392S -RRB- MMP-2 were inhibited by tissue_inhibitor_of_metalloproteinases _ -LRB- TIMP -RRB- -1 , _ -2 , _ and _ -4 and by the zinc chelators 1,10-phenanthroline and a synthetic hydroxamate inhibitor , Batimastat , similar to the wild-type protein , indicating an unaltered active site topography .
15095267	7	1,10-phenanthroline	1802,1821	MMP-2	1658,1663	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|END_ENTITY	Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline .
24136115	8	1,10-phenanthroline	1542,1561	MMP-2	1437,1442	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	inhibitor|appos|START_ENTITY inhibited|nmod|inhibitor inhibited|nsubj|activation activation|compound|END_ENTITY	The MMP-2 platelet activation pathway can be synergistically inhibited with the non-selective MMP inhibitor , 1,10-phenanthroline , plus a JAK_2 inhibitor .
9699154	6	1,10-phenanthroline	1162,1181	MMP-2	1067,1072	1,10-phenanthroline	MMP-2	MESH:C025205	4313	Chemical	Gene	presence|nmod|START_ENTITY inhibited|nmod|presence confirmed|conj|inhibited confirmed|nmod|A A|appos|END_ENTITY	This 66 kDa MMP was confirmed as gelatinase A -LRB- MMP-2 -RRB- based on the results of its activity dependent on Ca2 + and inhibited in the presence of 1,10-phenanthroline or EDTA , as well as its specific immunoreactivity on the Western blot .
8045973	5	1,10-phenanthroline	974,993	MMP-3	806,811	1,10-phenanthroline	MMP-3	MESH:C025205	4314	Chemical	Gene	confirmed|conj|START_ENTITY confirmed|nsubj|Identities Identities|nmod|MMP-1 MMP-1|conj|END_ENTITY	Identities of MMP-1 and MMP-3 were confirmed by Western blots , by comparison of mol wt with those of purified enzymes on casein zymography , and by inhibition of these activities with EDTA and 1,10-phenanthroline .
10556832	7	1,10-phenanthroline	987,1006	MMP8	1093,1097	1,10-phenanthroline	MMP8	MESH:C025205	4317	Chemical	Gene	START_ENTITY|conj|antibody antibody|nmod|END_ENTITY	Furthermore the cleavage was blocked by the metalloprotease inhibitor 1,10-phenanthroline -LRB- 70 + / - 6 % -RRB- as well as by a monoclonal antibody against human neutrophil collagenase MMP8 -LRB- 40 + / - 10 % -RRB- .
14511382	4	1,10-phenanthroline	904,923	MMP-9	794,799	1,10-phenanthroline	MMP-9	MESH:C025205	4318	Chemical	Gene	EDTA|amod|START_ENTITY concentration|nmod|EDTA independent|nmod|concentration independent|nsubj|activation activation|nmod|complex complex|compound|END_ENTITY	The calcium-induced activation and truncation of the MMP-9 / CSPG complex was independent of the concentration of the complex , inhibited by the MMP inhibitors EDTA , 1,10-phenanthroline and TIMP-1 , but not by general inhibitors of serine , thiol and acid proteinases .
9376127	5	1,10-phenanthroline	775,794	MMP-9	975,980	1,10-phenanthroline	MMP-9	MESH:C025205	4318	Chemical	Gene	chymostatin|amod|START_ENTITY inhibited|nmod|chymostatin inhibited|conj|involved involved|nsubjpass|MMP MMP|amod|END_ENTITY	Matrigel transmigration of eosinophils induced by PAF and IL-5 was inhibited by 1,10-phenanthroline , batimastat , 3,4-dichloroisocoumarin , chymostatin , and a neutralizing antibody for the matrix_metalloproteinase _ -LRB- MMP -RRB- -9 , indicating that serine proteinase -LRB- s -RRB- and MMP , specifically MMP-9 , were involved in the transmigration of eosinophils through Matrigel .
20172583	7	1,10-phenanthroline	898,917	MS2	872,875	1,10-phenanthroline	MS2	MESH:C025205	100271694	Chemical	Gene	resulted|nsubj|START_ENTITY inhibited|advcl|resulted inhibited|dobj|inactivation inactivation|compound|END_ENTITY	The addition of oxalate and humic_acids significantly inhibited the MS2 inactivation , whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2 .
20172583	7	1,10-phenanthroline	898,917	MS2	982,985	1,10-phenanthroline	MS2	MESH:C025205	100271694	Chemical	Gene	resulted|nsubj|START_ENTITY resulted|nmod|inactivation inactivation|nmod|END_ENTITY	The addition of oxalate and humic_acids significantly inhibited the MS2 inactivation , whereas 1,10-phenanthroline and bipyridine resulted in a gradual and steady inactivation of MS2 .
21726084	5	1,10-phenanthroline	906,925	MS2	1007,1010	1,10-phenanthroline	MS2	MESH:C025205	100271694	Chemical	Gene	addition|nmod|START_ENTITY block|nsubj|addition block|dobj|inactivation inactivation|nmod|END_ENTITY	First , the addition of 1,10-phenanthroline -LRB- a strong Fe -LRB- II -RRB- - chelating agent -RRB- failed to completely block the inactivation of MS2 by nZVI .
15095267	7	1,10-phenanthroline	1802,1821	MT1-MMP	1665,1672	1,10-phenanthroline	MT1-MMP	MESH:C025205	4323	Chemical	Gene	inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|MMP-2 MMP-2|conj|END_ENTITY	Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline .
11404220	8	1,10-phenanthroline	1270,1289	mTOR	1091,1095	1,10-phenanthroline	mTOR	MESH:C025205	56718(Tax:10116)	Chemical	Gene	incubation|nmod|START_ENTITY had|nsubj|incubation stimulated|advcl|had stimulated|nsubjpass|activities activities|nmod|END_ENTITY	Furthermore , the protein kinase activities of mTOR immunoprecipitated from rat brain lysates were stimulated two - to fivefold by 10-300 microM Zn2 + in the presence of an excess of either Mn2 + or Mg2 + , whereas incubation with 1,10-phenanthroline had no effect .
25548410	5	1,10-phenanthroline	927,946	mTOR	975,979	1,10-phenanthroline	mTOR	MESH:C025205	2475	Chemical	Gene	Pretreatment|amod|START_ENTITY disappeared|nsubj|Pretreatment disappeared|dobj|cleavage cleavage|compound|END_ENTITY	Pretreatment of T. _ vaginalis with a metalloproteinase inhibitor , 1,10-phenanthroline , completely disappeared the mTOR cleavage in SiHa cells .
26517723	7	1,10-phenanthroline	1149,1168	mucin	976,981	1,10-phenanthroline	mucin	MESH:C025205	100508689	Chemical	Gene	leucine|conj|START_ENTITY induce|advcl|leucine induce|nsubj|components components|nmod|END_ENTITY	Seven components , including porcine gastric mucin , lincomycin , glutamine , and glucose were found to induce CFA/I surface expression in vitro in a minimal media while five others were inhibitory , including leucine and 1,10-phenanthroline .
18486963	1	1,10-phenanthroline	218,237	NaF	210,213	1,10-phenanthroline	NaF	MESH:C025205	3576	Chemical	Gene	END_ENTITY|conj|START_ENTITY	The removal of Cr -LRB- VI -RRB- by zero-valent iron -LRB- Fe -LRB- 0 -RRB- -RRB- and the effect of three complex reagents , ethylenediaminetetraacetic_acid -LRB- EDTA -RRB- , NaF and 1,10-phenanthroline , on this reaction were investigated using batch reactors at pH values of 4 , 5 and 6 .
1618157	5	1,10-phenanthroline	974,993	N-cadherin	1015,1025	1,10-phenanthroline	N-cadherin	MESH:C025205	1000	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|loss loss|nmod|END_ENTITY	Furthermore , the metalloprotease inhibitor 1,10-phenanthroline inhibits the loss of N-cadherin from the retina .
15819038	1	1,10-phenanthroline	250,269	Nd3	205,208	1,10-phenanthroline	Nd3	MESH:C025205	4537	Chemical	Gene	alpha-amino-acids|conj|START_ENTITY solution|amod|alpha-amino-acids +|nmod|solution complexes|conj|+ complexes|nmod|+ +|amod|END_ENTITY	The absorption spectra of f-f hypersensitive transition for the complexes of Nd3 + or Er3 + with some alpha-amino-acids and 1,10-phenanthroline in 95 % ethanol solution were studied .
3681301	8	1,10-phenanthroline	1450,1469	neurotensin	1546,1557	1,10-phenanthroline	neurotensin	MESH:C025205	67405(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY combination|nmod|inhibitors inhibit|nsubj|combination inhibit|dobj|degradation degradation|nmod|END_ENTITY	A combination of the protease inhibitors 1,10-phenanthroline and Z-Pro-Prolinal was able to inhibit almost completely the degradation of neurotensin by clone N1E-115 .
17239391	6	1,10-phenanthroline	1284,1303	NS2/3	1216,1221	1,10-phenanthroline	NS2/3	MESH:C025205	57762;3845	Chemical	Gene	sensitive|advcl|START_ENTITY sensitive|nsubj|activity activity|compound|END_ENTITY	Lastly we show that the NS2/3 auto-cleavage activity is more sensitive to zinc chelation by 1,10-phenanthroline than the NS3 protease activity .
17239391	6	1,10-phenanthroline	1284,1303	NS3	1313,1316	1,10-phenanthroline	NS3	MESH:C025205	3845	Chemical	Gene	sensitive|advcl|START_ENTITY sensitive|nmod|activity activity|compound|END_ENTITY	Lastly we show that the NS2/3 auto-cleavage activity is more sensitive to zinc chelation by 1,10-phenanthroline than the NS3 protease activity .
8853454	2	1,10-phenanthroline	467,486	nuclease	446,454	1,10-phenanthroline	nuclease	MESH:C025205	14568893	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Since methyl substitution at all but the 2 and 9 positions enhances the copper-dependent chemical nuclease activity of 1,10-phenanthroline , we have compared the activity of conjugates prepared from 5 - -LRB- aminomethyl -RRB- -1,10 - phenanthroline -LRB- MOP -RRB- to those of conjugates prepared from 5-amino-1 ,10 - phenanthroline -LRB- amino-OP -RRB- .
10564652	4	1,10-phenanthroline	665,684	Occludin	595,603	1,10-phenanthroline	Occludin	MESH:C025205	100506658	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|proteolysis proteolysis|compound|END_ENTITY	Occludin proteolysis was inhibited by the metalloproteinase inhibitor 1,10-phenanthroline -LRB- PHEN -RRB- , but not by inhibitors against other types of proteases .
11278521	6	1,10-phenanthroline	768,787	OLE1	696,700	1,10-phenanthroline	OLE1	MESH:C025205	852825(Tax:4932)	Chemical	Gene	presence|nmod|START_ENTITY increased|nmod|presence increased|nsubjpass|expression expression|compound|END_ENTITY	OLE1 expression was also increased in the presence of the iron chelator 1,10-phenanthroline .
1581303	6	1,10-phenanthroline	968,987	oviductin	770,779	1,10-phenanthroline	oviductin	MESH:C025205	398108(Tax:8355)	Chemical	Gene	iodoacetamide|conj|START_ENTITY did|nsubj|iodoacetamide inhibited|conj|did inhibited|dobj|irreversibly irreversibly|compound|END_ENTITY	Diisopropyl_fluorophosphate , EDTA , and EGTA inhibited oviductin irreversibly ; soybean trypsin inhibitor , aprotinin , guanidine_hydrochloride -LRB- Ki = 7.5 mM -RRB- , and p-amino-benzamidine -LRB- Ki = 4.1 microM -RRB- also inhibited , but iodoacetamide , E-64 , pepstatin , or 1,10-phenanthroline did not .
8221671	5	1,10-phenanthroline	687,706	p53	632,635	1,10-phenanthroline	p53	MESH:C025205	7157	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|nmod|protein protein|compound|END_ENTITY	The DNA-binding activity of wild-type p53 hybrid protein was inhibited by the metal chelator 1,10-phenanthroline .
8467489	2	1,10-phenanthroline	337,356	p53	375,378	1,10-phenanthroline	p53	MESH:C025205	7157	Chemical	Gene	exposure|nmod|START_ENTITY induces|nsubj|exposure induces|dobj|END_ENTITY	Here we show that exposure to the metal chelator 1,10-phenanthroline induces wild-type p53 to adopt the mutant conformation and that this process is reversible .
9053835	0	1,10-phenanthroline	46,65	p53	14,17	1,10-phenanthroline	p53	MESH:C025205	22060(Tax:10090)	Chemical	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p53 transcriptional activity by 1,10-phenanthroline , a metal chelator and redox sensitive compound .
9053835	4	1,10-phenanthroline	724,743	p53	777,780	1,10-phenanthroline	p53	MESH:C025205	22060(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|activity activity|compound|END_ENTITY	The results showed that none of these in vitro active reagents , except 1,10-phenanthroline -LRB- OP -RRB- has a significant effect on p53 transactivation activity .
18961687	2	1,10-phenanthroline	399,418	PAN	505,508	1,10-phenanthroline	PAN	MESH:C025205	51816	Chemical	Gene	absence|nmod|START_ENTITY -LSB-|nmod|absence -LSB-|dobj|-RSB- -RSB-|conj|release release|nmod|END_ENTITY	In the absence of 1,10-phenanthroline the rate law is expressed as - d -LSB- CuR -LRB- + -RRB- -RSB- / dt = 10 -LRB- 3.2 -RRB- -LSB- CuR -LRB- + -RRB- -LSB- Y ' -RSB- , and the release of PAN from the reaction intermediate CuRY is the rate-determining step .
15305021	5	1,10-phenanthroline	992,1011	PAP-I	1059,1064	1,10-phenanthroline	PAP-I	MESH:C025205	290648(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|conj|inhibited inhibited|nmod|antibody antibody|nmod|END_ENTITY	The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I .
15305021	5	1,10-phenanthroline	992,1011	PAP-II	966,972	1,10-phenanthroline	PAP-II	MESH:C025205	366894(Tax:10116)	Chemical	Gene	START_ENTITY|amod|END_ENTITY	The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I .
6208907	1	1,10-phenanthroline	137,156	PC-3	235,239	1,10-phenanthroline	PC-3	MESH:C025205	57332	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|lines lines|conj|END_ENTITY	The metal chelator 1,10-phenanthroline reversibly inhibits proliferation of two human prostate_carcinoma cell lines , PC-3 and DU145 .
18950242	1	1,10-phenanthroline	132,151	PdI2	153,157	1,10-phenanthroline	PdI2	MESH:C025205	11240	Chemical	Gene	Cu2O|conj|START_ENTITY Cu2O|conj|END_ENTITY	A new catalyst system , generated in situ from Cu2O , 1,10-phenanthroline , PdI2 , and Tol-BINAP , for the first time allows the decarboxylative coupling of carboxylic_acids with aryl_triflates .
15271515	1	1,10-phenanthroline	177,196	pen	340,343	1,10-phenanthroline	pen	MESH:C025205	27344	Chemical	Gene	phen|amod|START_ENTITY diimine|dep|phen diimine|conj|ligands ligands|dep|acyclovir acyclovir|dep|acy acy|conj|END_ENTITY	Platinum compounds containing an aromatic diimine -LRB- 1,10-phenanthroline or 2,9-dimethyl-1 ,10 - phenanthroline ; phen and Me -LRB- 2 -RRB- phen , respectively -RRB- and antiviral guanosine-type ligands -LRB- acyclovir or penciclovir ; acy and pen , respectively -RRB- have been synthesised .
15018508	1	1,10-phenanthroline	189,208	PF6	251,254	1,10-phenanthroline	PF6	MESH:C025205	200162	Chemical	Gene	attached|nmod|START_ENTITY pyridines|acl|attached consists|nmod|pyridines consists|dobj|2 2|appos|END_ENTITY	The reaction between ligand 1 , which consists of two terminal pyridines attached to a central 1,10-phenanthroline -LRB- phen -RRB- , and the complex Ru -LRB- phen -RRB- 2 -LRB- CH3CN -RRB- 2 -LRB- PF6 -RRB- 2 has been studied .
8129736	0	1,10-phenanthroline	18,37	phospholipase_D	154,169	1,10-phenanthroline	phospholipase D	MESH:C025205	2822	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effects effects|nmod|fibroblasts fibroblasts|compound|activators activators|conj|staurosporine staurosporine|nmod|activity activity|amod|END_ENTITY	The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine , but not sphingosine and H2O2 , on phospholipase_D activity in NIH 3T3 fibroblasts .
11516173	4	1,10-phenanthroline	572,591	P-LAP	550,555	1,10-phenanthroline	P-LAP	MESH:C025205	4012	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nsubj|EDTA affect|advcl|inhibited affect|dobj|secretion secretion|nmod|END_ENTITY	Inhibitors of serine or aspartic proteases did not affect the secretion of P-LAP , while EDTA and 1,10-phenanthroline inhibited it .
28520424	1	1,10-phenanthroline	211,230	PPh2	184,188	1,10-phenanthroline	PPh2	MESH:C025205	89873	Chemical	Gene	phen|ccomp|START_ENTITY -RSB-|dep|phen Herein|nsubj|-RSB- Herein|dep|present present|nmod|reaction reaction|nmod|_ _|appos|END_ENTITY	Herein we present a theoretical study on the reaction of -LSB- Re -LRB- PPh2 -RRB- _ -LRB- CO -RRB- 3 -LRB- phen -RRB- -RSB- -LRB- phen = 1,10-phenanthroline -RRB- and -LSB- Re -LRB- PPh2 -RRB- _ -LRB- CO -RRB- 3 -LRB- bipy -RRB- -RSB- -LRB- bipy = 2,2 ' - bipyridine -RRB- toward methyl_propiolate .
18510330	2	1,10-phenanthroline	487,506	PPh_3	508,513	1,10-phenanthroline	PPh 3	MESH:C025205	857	Chemical	Gene	START_ENTITY|appos|END_ENTITY	The method involves highly selective intramolecular coupling of lactam and dihaloalkene using 2,2 ' - bipyridine as a ligand , followed by intermolecular C-S formation in the presence of another ligand -LRB- 1,10-phenanthroline , PPh_3 -RRB- and mercaptan .
11304151	1	1,10-phenanthroline	201,220	PPh4	133,137	1,10-phenanthroline	PPh4	MESH:C025205	3777	Chemical	Gene	-RSB-|dep|START_ENTITY -RSB-|nsubj|structures structures|conj|properties properties|nmod|Fe Fe|compound|END_ENTITY	Crystal structures and magnetic properties of PPh4 -LSB- Fe -LRB- Phen -RRB- -LRB- CN -RRB- 4 -RSB- * 2H2O and -LSB- -LSB- Fe -LRB- Phen -RRB- -LRB- CN -RRB- 4 -RSB- 2M -LRB- H2O -RRB- 2 -RSB- * 4H2O -LSB- Phen = 1,10-phenanthroline ; M = Mn -LRB- II -RRB- and Zn -LRB- II -RRB- -RSB- .
10441503	3	1,10-phenanthroline	557,576	PPMT	600,604	1,10-phenanthroline	PPMT	MESH:C025205	170818(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|activity activity|amod|END_ENTITY	Unlike EDTA and EGTA , the metal chelator 1,10-phenanthroline strongly inhibited the PPMT activity of kidney intracellular membranes in a dose - and time-dependent manner .
10441503	8	1,10-phenanthroline	1434,1453	PPMT	1495,1499	1,10-phenanthroline	PPMT	MESH:C025205	170818(Tax:10116)	Chemical	Gene	membranes|nmod|START_ENTITY Treatment|nmod|membranes increased|nsubj|Treatment increased|dobj|degradation degradation|nmod|END_ENTITY	Treatment of kidney intracellular membranes with 1,10-phenanthroline increased the proteolytic degradation of PPMT by exogenous trypsin , compared to untreated membranes .
14663496	7	1,10-phenanthroline	879,898	proteinase	851,861	1,10-phenanthroline	proteinase	MESH:C025205	100862683	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	The proteinase was inhibited by 1,10-phenanthroline and EDTA , showing that it belonged to the metalloproteinase class .
15545371	7	1,10-phenanthroline	696,715	proteinase	745,755	1,10-phenanthroline	proteinase	MESH:C025205	100862683	Chemical	Gene	EDTA|dep|START_ENTITY compounds|dep|EDTA inactivated|nmod|compounds inactivated|conj|affected affected|nmod|inhibitors inhibitors|amod|END_ENTITY	The enzyme was inactivated by metal-chelating compounds -LRB- EDTA , 1,10-phenanthroline -RRB- and less affected by serine proteinase inhibitors -LRB- diisopropylfluorophosphate , phenylmethylsulfonyl_fluoride -RRB- .
3680518	7	1,10-phenanthroline	1003,1022	proteinase	1107,1117	1,10-phenanthroline	proteinase	MESH:C025205	100862683	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|xcomp|indicating indicating|ccomp|metalloproteinase metalloproteinase|nsubj|END_ENTITY	The proteolytic activity in the gelatin-Sepharose-purified material was inhibited by EDTA and 1,10-phenanthroline , but not by N-ethylmaleimide or phenylmethanesulfonyl_fluoride , indicating that the proteinase was a metalloproteinase .
19134000	4	1,10-phenanthroline	632,651	PTEN	595,599	1,10-phenanthroline	PTEN	MESH:C025205	5728	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	EXPERIMENTAL APPROACH : We evaluated the ability of a PTEN inhibitor , potassium_bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate -LSB- bpV -LRB- phen -RRB- -RSB- , to prevent acute_lung_injury induced by oleic_acid -LRB- OA -RRB- in adult C57BL/6 mice .
22918949	4	1,10-phenanthroline	922,941	PTEN	898,902	1,10-phenanthroline	PTEN	MESH:C025205	399142(Tax:8355)	Chemical	Gene	bisperoxo|dep|START_ENTITY bisperoxo|compound|END_ENTITY	In Xenopus nerve-muscle cocultures , axonal growth speed was halved after contact with muscle , when compared with before contact , but when cultures were exposed to the PTEN blocker bisperoxo -LRB- 1,10-phenanthroline -RRB- oxovanadate , axons touching muscle grew ~ 50 % faster than their counterparts in control cultures .
2550050	7	1,10-phenanthroline	1188,1207	pump-1	1159,1165	1,10-phenanthroline	pump-1	MESH:C025205	4316	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA inhibited|nsubjpass|END_ENTITY	Active pump-1 is inhibited by EDTA , 1,10-phenanthroline , and the tissue inhibitor of metalloproteinases .
3415670	0	1,10-phenanthroline	54,73	pyruvate_carboxylase	30,50	1,10-phenanthroline	pyruvate carboxylase	MESH:C025205	374263(Tax:9031)	Chemical	Gene	END_ENTITY|advcl|START_ENTITY	Inactivation of chicken liver pyruvate_carboxylase by 1,10-phenanthroline .
3415670	1	1,10-phenanthroline	149,168	pyruvate_carboxylase	105,125	1,10-phenanthroline	pyruvate carboxylase	MESH:C025205	374263(Tax:9031)	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Inactivation of chicken liver pyruvate_carboxylase by the chelating agent 1,10-phenanthroline follows pseudo-first-order kinetics .
3415670	3	1,10-phenanthroline	479,498	pyruvate_carboxylase	502,522	1,10-phenanthroline	pyruvate carboxylase	MESH:C025205	374263(Tax:9031)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Binding of 1,10-phenanthroline to pyruvate_carboxylase results in complete loss of ATP/Pi exchange activity , but only a 61 % decrease in pyruvate/oxaloacetate exchange activity .
10441503	7	1,10-phenanthroline	1352,1371	RhoA	1283,1287	1,10-phenanthroline	RhoA	MESH:C025205	117273(Tax:10116)	Chemical	Gene	present|nsubj|START_ENTITY inhibited|advcl|present inhibited|nsubj|methylation methylation|nmod|Ras Ras|conj|END_ENTITY	In addition , the methylation of immunoprecipitated Ras and RhoA from kidney intracellular membranes was strongly inhibited when 1,10-phenanthroline was present .
15169913	2	1,10-phenanthroline	407,426	rpb1-1	448,454	1,10-phenanthroline	rpb1-1	MESH:C025205	854157(Tax:4932)	Chemical	Gene	thiolutin|conj|START_ENTITY effects|nmod|thiolutin similar|nsubj|effects similar|advcl|END_ENTITY	Among the five inhibitors tested , the effects of thiolutin and 1,10-phenanthroline were most similar to rpb1-1 .
9541592	12	1,10-phenanthroline	1875,1894	rTRAIL	1724,1730	1,10-phenanthroline	rTRAIL	MESH:C025205	246775(Tax:10116)	Chemical	Gene	leupeptin|conj|START_ENTITY blocked|nmod|leupeptin dependent|advcl|blocked dependent|nsubj|generation generation|nmod|END_ENTITY	An in vitro cleavage assay showed that generation of soluble rTRAIL was dependent on the functional activity of cysteine proteases , as it was blocked by leupeptin and E64 but not by the metalloprotease inhibitor 1,10-phenanthroline .
1842102	1	1,10-phenanthroline	261,280	Ru2	222,225	1,10-phenanthroline	Ru2	MESH:C025205	51473	Chemical	Gene	molecules|amod|START_ENTITY consisting|nmod|molecules synthesized|advcl|consisting synthesized|dobj|complexes complexes|nmod|compound compound|acl:relcl|coordinated coordinated|nsubjpass|+ +|conj|+ +|compound|END_ENTITY	We have synthesized two metal complexes of the macrocyclic compound -LRB- III , IV -RRB- , with which either Cu2 + or Ru2 + is coordinated , consisting of two 1,10-phenanthroline molecules bridged by sulfur .
1169300	2	1,10-phenanthroline	209,228	S203-2	127,133	1,10-phenanthroline	S203-2	MESH:C025205	1078351(Tax:198215)	Chemical	Gene	-RSB-|amod|START_ENTITY tetrahydroxyfluoran_methyl_ester|conj|-RSB- tetrahydroxyfluoran_methyl_ester|dep|determination determination|nmod|-RSB- -RSB-|appos|I I|dep|END_ENTITY	Spectrophotometric determination of Ag -LSB- i -RSB- , CN - , I - and S203-2 - with 3,4,5,6-tetrachloro _ 3 ' ,4 ' ,5 ' ,6 ' = tetrahydroxyfluoran_methyl_ester and 1,10-phenanthroline -LRB- author 's transl -RRB- -RSB- .
21355074	6	1,10-phenanthroline	1029,1048	S2P	1176,1179	1,10-phenanthroline	S2P	MESH:C025205	270669(Tax:10090)	Chemical	Gene	reproduces|nsubj|START_ENTITY reproduces|ccomp|observed observed|nmod|cells cells|acl:relcl|implicates implicates|dobj|END_ENTITY	In contrast , 1,10-phenanthroline , an S2P-specific inhibitor , reproduces the molecular and biological phenotypes observed in NFV-treated cells , which implicates S2P as a target of NFV .
22540830	8	1,10-phenanthroline	1347,1366	S2P	1371,1374	1,10-phenanthroline	S2P	MESH:C025205	51360	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	In contrast , 1,10-phenanthroline , an S2P inhibitor , reproduced the nelfinavir-treated molecular and biological phenotype .
25880275	4	1,10-phenanthroline	720,739	S2P	693,696	1,10-phenanthroline	S2P	MESH:C025205	51360	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Nelfinavir and its analogs are more potent inhibitors of S2P cleavage activity than 1,10-phenanthroline , a metalloprotease-specific inhibitor .
17467053	7	1,10-phenanthroline	1127,1146	SDF-1	1041,1046	1,10-phenanthroline	SDF-1	MESH:C025205	6387	Chemical	Gene	pretreatment|amod|START_ENTITY decreased|nmod|pretreatment decreased|advcl|induced induced|nsubj|spontaneous spontaneous|conj|END_ENTITY	While , spontaneous and SDF-1 induced migration of UCB and MPB , but not BM CD34 -LRB- + -RRB- cells were decreased after 1,10-phenanthroline -LRB- an inhibitor of GPI-PLD -RRB- pretreatment .
12007650	5	1,10-phenanthroline	907,926	serine_protease	743,758	1,10-phenanthroline	serine protease	MESH:C025205	547512(Tax:3847)	Chemical	Gene	mM|nmod|START_ENTITY blocked|nmod|mM inhibited|parataxis|blocked inhibited|nmod|inhibitors inhibitors|amod|END_ENTITY	Protease A activity was inhibited by serine_protease inhibitors , such as phenylmethylsulfonyl_fluoride and soybean trypsin inhibitor ; moreover , the activity could be blocked by treatment with 20 mM of 1,10-phenanthroline , but could not be restored by adding metal ions .
1913672	4	1,10-phenanthroline	571,590	serine_protease	625,640	1,10-phenanthroline	serine protease	MESH:C025205	2147	Chemical	Gene	EDTA|conj|START_ENTITY affected|nmod|EDTA affected|xcomp|indicating indicating|ccomp|END_ENTITY	This activity has maximal activity at pH 8 and was inhibited by diisopropylfluorophosphate but was not affected by EDTA or 1,10-phenanthroline , indicating that this enzyme is a serine_protease .
7507963	4	1,10-phenanthroline	395,414	serine_protease	429,444	1,10-phenanthroline	serine protease	MESH:C025205	2147	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Here , metalloprotease -LRB- s -RRB- inhibitable by 1,10-phenanthroline together with serine_protease -LRB- s -RRB- inhibitable by N_alpha-p-tosyl-L-lysine_chloromethyl_ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43 , CD44 , and CD16 but not in the cleavage of L-selectin on granulocytes .
9763222	6	1,10-phenanthroline	1142,1161	serine_protease	1196,1211	1,10-phenanthroline	serine protease	MESH:C025205	2147	Chemical	Gene	START_ENTITY|acl|indicating indicating|dobj|nature nature|amod|END_ENTITY	Moreover , this enzyme was inhibited mostly by the serine-protease inhibitors leupeptin and di-isopropyl_fluorophosphate and not by the cysteine protease inhibitor E-64 or the metalloprotease inhibitor 1,10-phenanthroline -LRB- Component_H , CH -RRB- , indicating the serine_protease nature of this enzyme .
9763222	6	1,10-phenanthroline	1142,1161	serine-protease	991,1006	1,10-phenanthroline	serine-protease	MESH:C025205	2147	Chemical	Gene	E-64|conj|START_ENTITY leupeptin|conj|E-64 leupeptin|amod|END_ENTITY	Moreover , this enzyme was inhibited mostly by the serine-protease inhibitors leupeptin and di-isopropyl_fluorophosphate and not by the cysteine protease inhibitor E-64 or the metalloprotease inhibitor 1,10-phenanthroline -LRB- Component_H , CH -RRB- , indicating the serine_protease nature of this enzyme .
20094679	0	1,10-phenanthroline	48,67	SERS	0,4	1,10-phenanthroline	SERS	MESH:C025205	54938	Chemical	Gene	adsorption|nmod|START_ENTITY investigation|nmod|adsorption investigation|nsubj|END_ENTITY	SERS and DFT investigation on the adsorption of 1,10-phenanthroline on transition_metal surfaces .
20094679	1	1,10-phenanthroline	114,133	SERS	98,102	1,10-phenanthroline	SERS	MESH:C025205	54938	Chemical	Gene	phen|amod|START_ENTITY spectra|nmod|phen spectra|compound|END_ENTITY	SERS spectra of 1,10-phenanthroline -LRB- phen -RRB- on iron smooth surface doped with silver nanoparticles have been recorded and compared with those previously obtained on Ag doped smooth silver , copper and nickel surfaces .
19837674	2	1,10-phenanthroline	447,466	SERT	327,331	1,10-phenanthroline	SERT	MESH:C025205	6532	Chemical	Gene	copper|dep|START_ENTITY using|dobj|copper cross-linked|xcomp|using cross-linked|nsubjpass|residues residues|nmod|positions positions|nmod|transmembranes transmembranes|nmod|END_ENTITY	We show here that cysteine residues at positions in transmembranes 1 and 3 of SERT , like the corresponding positions in the gamma-aminobutyric_acid transporter , can be cross-linked using copper -LRB- II -RRB- -LRB- 1,10-phenanthroline -RRB- -LRB- 3 -RRB- .
24442907	0	1,10-phenanthroline	99,118	serum_albumin	139,152	1,10-phenanthroline	serum albumin	MESH:C025205	213	Chemical	Gene	L-histidine|conj|START_ENTITY ligands|amod|L-histidine containing|dobj|ligands containing|nmod|END_ENTITY	Multispectroscopic studies on the interaction of a platinum -LRB- II -RRB- complex containing L-histidine and 1,10-phenanthroline ligands with bovine serum_albumin .
25513861	1	1,10-phenanthroline	253,272	Serum_Albumin	290,303	1,10-phenanthroline	Serum Albumin	MESH:C025205	213	Chemical	Gene	=|ccomp|START_ENTITY -RSB-|parataxis|= -RSB-|advcl|investigated investigated|nsubjpass|HSA HSA|appos|END_ENTITY	The interaction between -LSB- Pd -LRB- But-dtc -RRB- -LRB- phen -RRB- -RSB- NO3 -LRB- where But-dtc = butyldithiocarbamate and phen = 1,10-phenanthroline -RRB- with HSA -LRB- Human Serum_Albumin -RRB- was investigated by applying fluorescence , UV-Vis and circular dichroism techniques under physiological conditions .
2157617	6	1,10-phenanthroline	970,989	SP1_and_transformed_glucocorticoid_receptor	1049,1092	1,10-phenanthroline	SP1 and transformed glucocorticoid receptor	MESH:C025205	6667	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|DNA DNA|nmod|END_ENTITY	Here , we report that although 1,10-phenanthroline , a metal ion chelating agent , inhibited the DNA binding of SP1_and_transformed_glucocorticoid_receptor , no inhibition of transformed AhR was observed .
1938939	4	1,10-phenanthroline	599,618	SSA4	799,803	1,10-phenanthroline	SSA4	MESH:C025205	856840(Tax:4932)	Chemical	Gene	intercalator|appos|START_ENTITY enhances|nsubj|intercalator enhances|dobj|abundance abundance|nmod|genes genes|appos|HSC82 HSC82|dep|END_ENTITY	Second , the DNA intercalator , 1,10-phenanthroline , widely employed as a general transcriptional inhibitor in S. _ cerevisiae , enhances the mRNA abundance of certain heat_shock genes -LRB- HSP82 , SSA1-SSA2 -RRB- although not of others -LRB- HSC82 , SSA4 , HSP26 -RRB- .
28208699	4	1,10-phenanthroline	828,847	syndecan-4	755,765	1,10-phenanthroline	syndecan-4	MESH:C025205	508133(Tax:9913)	Chemical	Gene	identified|dobj|START_ENTITY investigated|conj|identified investigated|advcl|determine determine|xcomp|capable capable|advcl|analyzing analyzing|dobj|expression expression|nmod|END_ENTITY	Here , we investigated organic-inorganic hybrid molecules to determine a variant capable of analyzing the expression of syndecan-4 , a transmembrane heparan-sulfate proteoglycan , and identified 1,10-phenanthroline -LRB- o-Phen -RRB- with or without zinc -LRB- Zn-Phen -RRB- or rhodium -LRB- Rh-Phen -RRB- .
26505793	0	1,10-phenanthroline	33,52	T2R5	69,73	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	START_ENTITY|nmod|transduction transduction|compound|END_ENTITY	GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell .
26505793	4	1,10-phenanthroline	760,779	T2R5	838,842	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	START_ENTITY|acl:relcl|known known|dobj|agonist agonist|nmod|taste_receptor_type_2_member_5 taste_receptor_type_2_member_5|appos|END_ENTITY	We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- .
26505793	5	1,10-phenanthroline	1043,1062	T2R5	1119,1123	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	ligand|conj|START_ENTITY able|csubj|ligand able|xcomp|secrete secrete|nmod|stimulation stimulation|nmod|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	5	1,10-phenanthroline	1043,1062	T2R5	991,995	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	ligand|conj|START_ENTITY ligand|conj|evaluated evaluated|dobj|existence existence|nmod|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	5	1,10-phenanthroline	911,930	T2R5	1119,1123	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	used|dobj|START_ENTITY used|advcl|able able|xcomp|secrete secrete|nmod|stimulation stimulation|nmod|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	5	1,10-phenanthroline	911,930	T2R5	991,995	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	used|dobj|START_ENTITY used|advcl|able able|csubj|ligand ligand|conj|evaluated evaluated|dobj|existence existence|nmod|END_ENTITY	To prove this hypothesis , we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells .
26505793	6	1,10-phenanthroline	1282,1301	T2R5	1219,1223	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	secreted|nmod|START_ENTITY colocalized|conj|secreted colocalized|nmod|END_ENTITY	Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells .
26505793	6	1,10-phenanthroline	1282,1301	T2R5	1306,1310	1,10-phenanthroline	T2R5	MESH:C025205	54429	Chemical	Gene	START_ENTITY|nmod|transduction transduction|compound|END_ENTITY	Consequently , we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells .
10727411	5	1,10-phenanthroline	979,998	TACE	805,809	1,10-phenanthroline	TACE	MESH:C025205	11491(Tax:10090)	Chemical	Gene	detected|conj|START_ENTITY detected|nsubj|form form|nmod|END_ENTITY	An additional form of TACE , lacking the pro and cytoplasmic domains , is detected when cell lysates are prepared in the presence of EDTA instead of a hydroxamate-based metalloprotease inhibitor or 1,10-phenanthroline .
26505793	4	1,10-phenanthroline	760,779	taste_receptor_type_2_member_5	806,836	1,10-phenanthroline	taste receptor type 2 member 5	MESH:C025205	54429	Chemical	Gene	START_ENTITY|acl:relcl|known known|dobj|agonist agonist|nmod|END_ENTITY	We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste_receptor_type_2_member_5 -LRB- T2R5 -RRB- .
1431887	1	1,10-phenanthroline	204,223	TFIIIA	147,153	1,10-phenanthroline	TFIIIA	MESH:C025205	397777(Tax:8355)	Chemical	Gene	treated|advcl|START_ENTITY isolated|conj|treated isolated|nsubjpass|Transcription_factor_IIIA Transcription_factor_IIIA|appos|END_ENTITY	Transcription_factor_IIIA -LRB- TFIIIA -RRB- was isolated from Xenopus ovary and treated with 1,10-phenanthroline to remove zinc .
9057093	10	1,10-phenanthroline	2054,2073	TGF_alpha	1982,1991	1,10-phenanthroline	TGF alpha	MESH:C025205	7039	Chemical	Gene	EDTA|conj|START_ENTITY inhibited|nmod|EDTA metalloenzyme|advcl|inhibited metalloenzyme|nsubj|ase ase|compound|END_ENTITY	Inhibition studies indicate that the plasma membrane `` TGF_alpha ase is a metalloenzyme as it was inhibited by EDTA , EGTA , and 1,10-phenanthroline but not by elastase or serine protease inhibitors .
9057093	11	1,10-phenanthroline	2195,2214	TGF_alpha	2126,2135	1,10-phenanthroline	TGF alpha	MESH:C025205	7039	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|compound|END_ENTITY	`` TGF_alpha ase '' activity on intact cells was shown to be inhibited by 1,10-phenanthroline , which further supports this suggestion .
1406451	7	1,10-phenanthroline	1337,1356	TIMP	1417,1421	1,10-phenanthroline	TIMP	MESH:C025205	7076	Chemical	Gene	tissue_inhibitor_of_metalloproteinase|amod|START_ENTITY tissue_inhibitor_of_metalloproteinase|appos|END_ENTITY	Similar to APMA-activated human prostromelysin-1 , the APMA-activated canine metalloproteinase was inhibited by 1,10-phenanthroline or recombinant human tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- .
8086430	4	1,10-phenanthroline	852,871	TIMP	934,938	1,10-phenanthroline	TIMP	MESH:C025205	7076	Chemical	Gene	EDTA|conj|START_ENTITY prevented|nmod|EDTA prevented|parataxis|compete compete|nsubj|END_ENTITY	Complex formation with the whole molecule is prevented by EDTA and by 1,10-phenanthroline demonstrating the importance of the active site ; additionally TIMP and TIMP-2 will compete with a reversibly bound peptide hydroxamic_acid inhibitor for the active site .
8238531	5	1,10-phenanthroline	1035,1054	TIMP	1026,1030	1,10-phenanthroline	TIMP	MESH:C025205	317694(Tax:9913)	Chemical	Gene	prevented|conj|START_ENTITY prevented|nmod|inclusion inclusion|nmod|tissue_inhibitor_of_metalloproteinase tissue_inhibitor_of_metalloproteinase|appos|END_ENTITY	Incubation of BPMVE cells with the 96-kDa gelatinase increased monolayer permeability , an effect prevented by inclusion of either tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- or 1,10-phenanthroline .
8499486	8	1,10-phenanthroline	1209,1228	TIMP	1233,1237	1,10-phenanthroline	TIMP	MESH:C025205	7076	Chemical	Gene	EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY	Several criteria indicate that this enzyme is a member of the family of matrix metalloproteinases : -LRB- 1 -RRB- this activity was inhibited by EDTA , 1,10-phenanthroline and TIMP ; -LRB- 2 -RRB- this activity bound to a gelatin-agarose affinity resin ; -LRB- 3 -RRB- it has a mass of approx .
10212153	8	1,10-phenanthroline	1384,1403	TIMP-1	1374,1380	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	END_ENTITY|conj|START_ENTITY	The addition of MMP inhibitors human recombinant TIMP-1 or 1,10-phenanthroline to cultures under basal conditions induced matrix deposition in a dose-dependent manner , which was not observed with the serine protease inhibitor epsilon-amino-n-caproic_acid -LRB- ACA -RRB- .
11162584	7	1,10-phenanthroline	927,946	TIMP-1	1072,1078	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	START_ENTITY|conj|inhibitors inhibitors|nmod|metalloproteinases metalloproteinases|amod|END_ENTITY	Its proteolytic activity was blocked by 1,10-phenanthroline , EDTA , EGTA , and a synthetic matrix metalloproteinase -LRB- MMP -RRB- inhibitor and not by the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 .
14511382	4	1,10-phenanthroline	904,923	TIMP-1	928,934	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	START_ENTITY|conj|END_ENTITY	The calcium-induced activation and truncation of the MMP-9 / CSPG complex was independent of the concentration of the complex , inhibited by the MMP inhibitors EDTA , 1,10-phenanthroline and TIMP-1 , but not by general inhibitors of serine , thiol and acid proteinases .
7615167	11	1,10-phenanthroline	1565,1584	TIMP-1	1539,1545	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Either TIMP-1 or the Zn chelator 1,10-phenanthroline reduced the zymographic activity in cryosections of atheroma from humans or rabbits .
7989608	10	1,10-phenanthroline	1661,1680	TIMP-1	1705,1711	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	inhibitors|conj|START_ENTITY MMP|amod|inhibitors MMP|conj|END_ENTITY	The MMP inhibitors , EDTA and 1,10-phenanthroline , as well as recombinant TIMP-1 , reduced these activities which colocalized with regions of increased immunoreactive MMP expression , i.e. , the shoulders , core , and microvasculature of the plaques .
8910479	7	1,10-phenanthroline	1259,1278	TIMP-1	1251,1257	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	END_ENTITY|conj|START_ENTITY	All activities were inhibited by TIMP-1 , 1,10-phenanthroline , and EDTA .
9548562	11	1,10-phenanthroline	1906,1925	TIMP-1	1971,1977	1,10-phenanthroline	TIMP-1	MESH:C025205	7076	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Ionomycin - and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- .
11162584	7	1,10-phenanthroline	927,946	TIMP-2	1083,1089	1,10-phenanthroline	TIMP-2	MESH:C025205	7077	Chemical	Gene	START_ENTITY|conj|inhibitors inhibitors|nmod|metalloproteinases metalloproteinases|amod|TIMP-1 TIMP-1|conj|END_ENTITY	Its proteolytic activity was blocked by 1,10-phenanthroline , EDTA , EGTA , and a synthetic matrix metalloproteinase -LRB- MMP -RRB- inhibitor and not by the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 .
15095267	7	1,10-phenanthroline	1802,1821	TIMP-2	1678,1684	1,10-phenanthroline	TIMP-2	MESH:C025205	7077	Chemical	Gene	inhibited|advcl|START_ENTITY activity|acl:relcl|inhibited exhibit|dobj|activity demonstrated|conj|exhibit demonstrated|dobj|localization localization|nmod|MMP-2 MMP-2|conj|END_ENTITY	Immunohistochemistry and in situ zymography demonstrated localization of MMP-2 , MT1-MMP , and TIMP-2 to carcinoma cells , but only in MECs did carcinoma cell nests exhibit gelatinolytic activity , which was inhibited by 1,10-phenanthroline .
1648398	4	1,10-phenanthroline	935,954	TIMP-2	1008,1014	1,10-phenanthroline	TIMP-2	MESH:C025205	374178(Tax:9031)	Chemical	Gene	EDTA|conj|START_ENTITY chelators|nmod|EDTA chelators|conj|inhibitors inhibitors|ref|that END_ENTITY|mark|that	The enzyme was inhibited by metal chelators such as EDTA and 1,10-phenanthroline , but not by inhibitors is suggested that this may be TIMP-2 .
8086430	4	1,10-phenanthroline	852,871	TIMP-2	943,949	1,10-phenanthroline	TIMP-2	MESH:C025205	7077	Chemical	Gene	EDTA|conj|START_ENTITY prevented|nmod|EDTA prevented|parataxis|compete compete|nsubj|TIMP TIMP|conj|END_ENTITY	Complex formation with the whole molecule is prevented by EDTA and by 1,10-phenanthroline demonstrating the importance of the active site ; additionally TIMP and TIMP-2 will compete with a reversibly bound peptide hydroxamic_acid inhibitor for the active site .
15013428	4	1,10-phenanthroline	779,798	TIMP-3	852,858	1,10-phenanthroline	TIMP-3	MESH:C025205	7078	Chemical	Gene	EDTA|conj|START_ENTITY EDTA|conj|tissue_inhibitor_of_metalloproteinases-3 tissue_inhibitor_of_metalloproteinases-3|dep|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
15013428	4	1,10-phenanthroline	779,798	TIMP-4	865,871	1,10-phenanthroline	TIMP-4	MESH:C025205	7079	Chemical	Gene	EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
1406451	7	1,10-phenanthroline	1337,1356	tissue_inhibitor_of_metalloproteinase	1378,1415	1,10-phenanthroline	tissue inhibitor of metalloproteinase	MESH:C025205	7076	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Similar to APMA-activated human prostromelysin-1 , the APMA-activated canine metalloproteinase was inhibited by 1,10-phenanthroline or recombinant human tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- .
8238531	5	1,10-phenanthroline	1035,1054	tissue_inhibitor_of_metalloproteinase	987,1024	1,10-phenanthroline	tissue inhibitor of metalloproteinase	MESH:C025205	317694(Tax:9913)	Chemical	Gene	prevented|conj|START_ENTITY prevented|nmod|inclusion inclusion|nmod|END_ENTITY	Incubation of BPMVE cells with the 96-kDa gelatinase increased monolayer permeability , an effect prevented by inclusion of either tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- or 1,10-phenanthroline .
9548562	11	1,10-phenanthroline	1906,1925	tissue_inhibitor_of_metalloproteinase-1	1930,1969	1,10-phenanthroline	tissue inhibitor of metalloproteinase-1	MESH:C025205	7076	Chemical	Gene	START_ENTITY|conj|END_ENTITY	Ionomycin - and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- .
10551873	8	1,10-phenanthroline	1339,1358	tissue_inhibitor_of_metalloproteinases-2	1448,1488	1,10-phenanthroline	tissue inhibitor of metalloproteinases-2	MESH:C025205	7077	Chemical	Gene	blocked|dep|START_ENTITY blocked|nsubj|reference reference|acl|hydroxamic_acid hydroxamic_acid|dobj|inhibitors inhibitors|conj|potently potently|amod|END_ENTITY	EDTA , 1,10-phenanthroline , reference hydroxamic_acid MMP inhibitors , tissue inhibitor of metalloproteinases-1 , and tissue_inhibitor_of_metalloproteinases-2 all potently blocked MT4-MMPCD enzymatic activity .
15013428	4	1,10-phenanthroline	779,798	tissue_inhibitor_of_metalloproteinases-3	810,850	1,10-phenanthroline	tissue inhibitor of metalloproteinases-3	MESH:C025205	7078	Chemical	Gene	EDTA|conj|START_ENTITY EDTA|conj|END_ENTITY	Processed ADAM28s digested insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in both free and complex forms with IGF-I or IGF-II , and the digestion was prevented with EDTA , 1,10-phenanthroline , KB-R7785 , tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- , and TIMP-4 .
10925303	8	1,10-phenanthroline	1102,1121	TNF	1236,1239	1,10-phenanthroline	TNF	MESH:C025205	7124	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|conj|considered considered|advcl|inhibited inhibited|dobj|activation activation|compound|END_ENTITY	Shedding was also inhibited by 1,10-phenanthroline , but this effect was considered nonspecific as the compound , at variance with KB8301 , almost completely inhibited TNF and FMLP-induced PMN activation .
10614779	4	1,10-phenanthroline	808,827	TNF-alpha	691,700	1,10-phenanthroline	TNF-alpha	MESH:C025205	7124	Chemical	Gene	also|dep|START_ENTITY inhibitors|conj|also inhibited|nmod|inhibitors inhibited|advcl|inhibited inhibited|dobj|processing processing|nmod|END_ENTITY	Although only hydroxamate matrix metalloproteinase -LRB- MMP -RRB- inhibitors inhibited the basal processing and release of TNF-alpha , the PMA-induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline , 3,4-dichloroisocoumarin -LRB- 3,4-DCI -RRB- , iodoacetamide , and Nalpha-p-tosyl-L-phenylalanine_chloromethyl_ketone -LRB- TPCK -RRB- .
10614779	5	1,10-phenanthroline	973,992	TNF-alpha	1021,1030	1,10-phenanthroline	TNF-alpha	MESH:C025205	7124	Chemical	Gene	inhibitors|conj|START_ENTITY MMP|amod|inhibitors inhibited|nsubj|MMP inhibited|dobj|processing processing|nmod|END_ENTITY	Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface , whereas 3,4-DCI , iodoacetamide , and TPCK inhibited the transport of TNF-alpha to the cell surface .
10614779	5	1,10-phenanthroline	973,992	TNF-alpha	1120,1129	1,10-phenanthroline	TNF-alpha	MESH:C025205	7124	Chemical	Gene	inhibitors|conj|START_ENTITY MMP|amod|inhibitors inhibited|nsubj|MMP inhibited|advcl|inhibited inhibited|dobj|transport transport|nmod|END_ENTITY	Hydroxamate MMP inhibitors and 1,10-phenanthroline inhibited the processing of TNF-alpha on the cell surface , whereas 3,4-DCI , iodoacetamide , and TPCK inhibited the transport of TNF-alpha to the cell surface .
11867336	6	1,10-phenanthroline	1456,1475	TNF-alpha	1316,1325	1,10-phenanthroline	TNF-alpha	MESH:C025205	24835(Tax:10116)	Chemical	Gene	inhibited|advcl|START_ENTITY abundance|acl:relcl|inhibited showed|nmod|abundance showed|nsubj|incubation incubation|nmod|medium medium|conj|END_ENTITY	IGFBP-4 specific proteolysis was examined in CM collected from fetal rat lung fibroblasts after incubation with serum-free medium -LRB- SFM -RRB- , IL-1beta , or TNF-alpha for 48 h. Cell-free aliquots of SFM-CM incubated at 37C for 24 h showed a 65 % decrease in IGFBP-4 abundance that was inhibited by 1,10-phenanthroline .
9688944	8	1,10-phenanthroline	1575,1594	TNF-alpha	1426,1435	1,10-phenanthroline	TNF-alpha	MESH:C025205	7124	Chemical	Gene	EDTA|conj|START_ENTITY aprotinin|conj|EDTA blocked|nmod|aprotinin medium|acl:relcl|blocked increased|nmod|medium increased|nsubj|END_ENTITY	Fn-substrate zymography revealed that TNF-alpha increased the expression of two proteinases within the conditioned medium in which activity could be blocked by aprotinin but not by EDTA , 1,10-phenanthroline , leupeptin , or pepstatin .
10754213	7	1,10-phenanthroline	916,935	TN-R	984,988	1,10-phenanthroline	TN-R	MESH:C025205	21960(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|release release|compound|END_ENTITY	In addition , 1,10-phenanthroline -LRB- a metalloprotease blocker -RRB- partially inhibited TN-R release in the presence of calcium ions .
21149586	7	1,10-phenanthroline	1462,1481	Tp0751	1392,1398	1,10-phenanthroline	Tp0751	MESH:C025205	2611130(Tax:243276)	Chemical	Gene	presence|nmod|START_ENTITY abolished|nmod|presence abolished|nsubjpass|activity activity|nmod|END_ENTITY	The proteolytic activity of Tp0751 was abolished by the presence of the metalloprotease inhibitor 1,10-phenanthroline .
1431887	1	1,10-phenanthroline	204,223	Transcription_factor_IIIA	120,145	1,10-phenanthroline	Transcription factor IIIA	MESH:C025205	397777(Tax:8355)	Chemical	Gene	treated|advcl|START_ENTITY isolated|conj|treated isolated|nsubjpass|END_ENTITY	Transcription_factor_IIIA -LRB- TFIIIA -RRB- was isolated from Xenopus ovary and treated with 1,10-phenanthroline to remove zinc .
6885162	1	1,10-phenanthroline	195,214	transferrin	155,166	1,10-phenanthroline	transferrin	MESH:C025205	7018	Chemical	Gene	serum|conj|START_ENTITY serum|appos|END_ENTITY	Human serum , human transferrin -LRB- TF -RRB- , and the iron chelator 1,10-phenanthroline -LRB- OP -RRB- produce iron-reversible fungistatic activity which has been attributed to simple iron deprivation .
15305021	5	1,10-phenanthroline	992,1011	TRH	918,921	1,10-phenanthroline	TRH	MESH:C025205	25569(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activities activities|nmod|END_ENTITY	The L-pGlu-cleaving activities toward TRH in rat brain homogenate were inhibited by a PAP-II specific inhibitor 1,10-phenanthroline , but not inhibited by the antibody against rat PAP-I .
19856296	5	1,10-phenanthroline	749,768	trypsin_inhibitor	681,698	1,10-phenanthroline	trypsin inhibitor	MESH:C025205	548021(Tax:3847)	Chemical	Gene	but|conj|START_ENTITY phenylmethane_sulfonylfluoride|dep|but phenylmethane_sulfonylfluoride|appos|END_ENTITY	Its pH optimum was in the range of 9-11 , it was remarkably heat-stable and was not inhibited by phenylmethane_sulfonylfluoride , soybean trypsin_inhibitor , aprotinin or alpha1-antitrypsin , but by EDTA and 1,10-phenanthroline suggesting properties of a metalloprotease .
16949178	6	1,10-phenanthroline	1186,1205	VEGF	1086,1090	1,10-phenanthroline	VEGF	MESH:C025205	7422	Chemical	Gene	using|xcomp|START_ENTITY using|nsubj|Neutralisation Neutralisation|nmod|END_ENTITY	Neutralisation of VEGF as well as inhibition of matrix metalloproteases -LRB- MMPs -RRB- using the broad spectrum MMP inhibitor 1,10-phenanthroline , both strongly reduced the melanoma-induced tube formation .
23249709	2	1,10-phenanthroline	375,394	VEGF	295,299	1,10-phenanthroline	VEGF	MESH:C025205	7422	Chemical	Gene	-RSB-|amod|START_ENTITY inhibitors|dep|-RSB- inhibitors|amod|vitro vitro|nmod|presence presence|nmod|END_ENTITY	METHODS : Human umbilical vein endothelial cells -LRB- HUVECs -RRB- were cultured in vitro in the presence or absence of VEGF , doxycycline , or broad-spectrum matrix metalloproteinase -LRB- MMP -RRB- inhibitors -LRB- 1,10-phenanthroline -LSB- 1PT -RSB- and batimastat -RRB- .
8226890	0	1,10-phenanthroline	130,149	YAP1	58,62	1,10-phenanthroline	YAP1	MESH:C025205	855005(Tax:4932)	Chemical	Gene	caused|advcl|START_ENTITY inhibition|acl|caused alleviates|dobj|inhibition alleviates|nsubj|Overexpression Overexpression|conj|END_ENTITY	Overexpression of YAP2 , coding for a new yAP protein , and YAP1 in Saccharomyces_cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline .
8226890	3	1,10-phenanthroline	484,503	YAP1	582,586	1,10-phenanthroline	YAP1	MESH:C025205	855005(Tax:4932)	Chemical	Gene	concentrations|nmod|START_ENTITY caused|nmod|concentrations yeast|acl|caused arrest|nmod|yeast overcome|nsubjpass|arrest overcome|nmod|over-expression over-expression|nmod|END_ENTITY	Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline , resulting in zinc and/or iron deprivation , is overcome by over-expression of YAP1 or YAP2 .
8226890	5	1,10-phenanthroline	792,811	yap2	704,708	1,10-phenanthroline	yap2	MESH:C025205	852033(Tax:4932)	Chemical	Gene	caused|advcl|START_ENTITY conditions|acl|caused thermotolerance|nmod|conditions has|dobj|thermotolerance has|nsubj|mutant mutant|amod|END_ENTITY	On the other hand , a yap2 null mutant has an increased thermotolerance under starvation conditions caused by 1,10-phenanthroline .
8226890	0	1,10-phenanthroline	130,149	YAP2	18,22	1,10-phenanthroline	YAP2	MESH:C025205	852033(Tax:4932)	Chemical	Gene	caused|advcl|START_ENTITY inhibition|acl|caused alleviates|dobj|inhibition alleviates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of YAP2 , coding for a new yAP protein , and YAP1 in Saccharomyces_cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline .
8226890	3	1,10-phenanthroline	484,503	YAP2	590,594	1,10-phenanthroline	YAP2	MESH:C025205	852033(Tax:4932)	Chemical	Gene	concentrations|nmod|START_ENTITY caused|nmod|concentrations yeast|acl|caused arrest|nmod|yeast overcome|nsubjpass|arrest overcome|nmod|over-expression over-expression|nmod|YAP1 YAP1|conj|END_ENTITY	Growth arrest of yeast caused by low concentrations of 1,10-phenanthroline , resulting in zinc and/or iron deprivation , is overcome by over-expression of YAP1 or YAP2 .
21724882	11	1,10-phenanthroline	1625,1644	Zap1p	1586,1591	1,10-phenanthroline	Zap1p	MESH:C025205	853390(Tax:4932)	Chemical	Gene	addition|nmod|START_ENTITY END_ENTITY|conj|addition	Paradoxically , deletion of the zinc-responsive transcription factor Zap1p or addition of the zinc chelator 1,10-phenanthroline significantly increased diclofenac toxicity , establishing a regulatory role for zinc in diclofenac resistance .
22252336	2	1,10-phenanthroline	558,577	zfVg1	448,453	1,10-phenanthroline	zfVg1	MESH:C025205	559475(Tax:7955)	Chemical	Gene	found|nsubjpass|START_ENTITY identified|conj|found identified|nsubjpass|1 1|appos|END_ENTITY	Two 30 - to 35-kDa polypeptides homologous to the N-terminal lipovitellin 1 -LRB- Lv1 -RRB- domain of the 150-kDa zebrafish vitellogenin 1 -LRB- zfVg1 -RRB- were identified as the damage recognition factors in zebrafish extracts , and the metal-chelating agent 1,10-phenanthroline -LRB- OP -RRB- was found to inhibit the embryonic UV-damaged-DNA binding activity .
16487686	8	1,10-phenanthroline	843,862	zinc-metallopeptidase	866,887	1,10-phenanthroline	zinc-metallopeptidase	MESH:C025205	79258	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The extracellular peptidases were most active in acidic pH -LRB- 5.5 -RRB- and fully inhibited by 1,10-phenanthroline , a zinc-metallopeptidase inhibitor .
2606151	5	1.10-phenanthroline	997,1016	ACE	1051,1054	1.10-phenanthroline	ACE	MESH:C025205	100715217	Chemical	Gene	incubated|advcl|START_ENTITY ileum|acl|incubated chelator|nmod|ileum chelator|xcomp|able able|xcomp|inhibit inhibit|dobj|END_ENTITY	Furthermore KPP potentiated the bradykinin contracting effects on the rat uterus , a preparation with very poor ACE activity , and on guinea-pig ileum previously incubated with 1.10-phenanthroline , a metal chelator able to inhibit ACE and kininase I activities and with phosphoramidon , a specific inhibitor of neutral endopeptidase -LRB- NEP -RRB- .
2606151	5	1.10-phenanthroline	997,1016	ACE	933,936	1.10-phenanthroline	ACE	MESH:C025205	24310(Tax:10116)	Chemical	Gene	incubated|advcl|START_ENTITY ileum|acl|incubated chelator|nmod|ileum potentiated|conj|chelator potentiated|nmod|activity activity|compound|END_ENTITY	Furthermore KPP potentiated the bradykinin contracting effects on the rat uterus , a preparation with very poor ACE activity , and on guinea-pig ileum previously incubated with 1.10-phenanthroline , a metal chelator able to inhibit ACE and kininase I activities and with phosphoramidon , a specific inhibitor of neutral endopeptidase -LRB- NEP -RRB- .
7759568	8	1-10_Phenanthroline	1092,1111	endooligopeptidase_A	975,995	1-10 Phenanthroline	endooligopeptidase A	MESH:C025205	170845(Tax:10116)	Chemical	Gene	DTNB|conj|START_ENTITY inhibited|nmod|DTNB enhanced|conj|inhibited enhanced|nmod|END_ENTITY	Similarly to rabbit brain endooligopeptidase_A , the PC12 endooligopeptidase_A-like activity was enhanced by DTT , totally inhibited by DTNB and 1-10_Phenanthroline , partially inhibited by cFP-AAF-pAb , and not affected by PMSF .
3166980	4	1,10-Phenanthroline	802,821	alcohol_dehydrogenase	870,891	1,10-Phenanthroline	alcohol dehydrogenase	MESH:C025205	10327	Chemical	Gene	competitively|amod|START_ENTITY inhibit|nsubj|competitively inhibit|dep|demonstrating demonstrating|nsubj|ethanol ethanol|amod|END_ENTITY	1,10-Phenanthroline and 4-methylpyrazole competitively inhibit both alcohol_dehydrogenase catalyzed ethanol and 3 beta-hydroxy-5_beta-steroid oxidation demonstrating that the catalysis of both types of substrates occurs at the same active site .
1793037	2	1,10-Phenanthroline	284,303	carboxypeptidase_B	307,325	1,10-Phenanthroline	carboxypeptidase B	MESH:C025205	24271(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	1,10-Phenanthroline , a carboxypeptidase_B inhibitor -LRB- 2 mg/kg i.p. -RRB- , in combination with captopril enhanced the algesic effect of PBQ by 309-360 % .
205625	5	1,10-Phenanthroline	587,606	cytochrome_c	630,642	1,10-Phenanthroline	cytochrome c	MESH:C025205	100053958(Tax:9796)	Chemical	Gene	reduction|amod|START_ENTITY reduction|nmod|Fe2 Fe2|amod|END_ENTITY	1,10-Phenanthroline inhibited reduction of cytochrome_c b Fe2 + .
6196359	9	1,10-Phenanthroline	880,899	factor_A	925,933	1,10-Phenanthroline	factor A	MESH:C025205	397777(Tax:8355)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|binding binding|nmod|END_ENTITY	1,10-Phenanthroline also inhibits binding of factor_A to the intragenic control region of the 5 S RNA gene .
20605713	0	1,10-Phenanthroline	0,19	glucose_oxidase	49,64	1,10-Phenanthroline	glucose oxidase	MESH:C025205	54363	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	1,10-Phenanthroline derivatives as mediators for glucose_oxidase .
7864812	15	1,10-Phenanthroline	2188,2207	IDE	2225,2228	1,10-Phenanthroline	IDE	MESH:C025205	25700(Tax:10116)	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|labelling labelling|compound|END_ENTITY	1,10-Phenanthroline -LRB- 2 mM -RRB- increased IDE labelling , but decreased the labelling of 82 and 27 kDa bands .
8024692	0	1,10-Phenanthroline	0,19	insulin	137,144	1,10-Phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|conj|has has|dobj|effect effect|nmod|ability ability|nmod:poss|END_ENTITY	1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels .
8024692	0	1,10-Phenanthroline	0,19	insulin	54,61	1,10-Phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|accumulation accumulation|nmod|END_ENTITY	1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels .
8024692	0	1,10-Phenanthroline	0,19	insulin	88,95	1,10-Phenanthroline	insulin	MESH:C025205	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|degradation degradation|compound|END_ENTITY	1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin 's ability to increase mRNA levels .
6208907	0	1,10-Phenanthroline	0,19	PC-3	101,105	1,10-Phenanthroline	PC-3	MESH:C025205	57332	Chemical	Gene	reversibility|amod|START_ENTITY inhibits|nsubj|reversibility inhibits|dobj|proliferation proliferation|nmod|lines lines|appos|END_ENTITY	1,10-Phenanthroline reversibility inhibits proliferation of two human prostate_carcinoma cell lines -LRB- PC-3 and DU145 -RRB- .
10441503	4	1,10-Phenanthroline	686,705	PPMT	846,850	1,10-Phenanthroline	PPMT	MESH:C025205	170818(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|methylation methylation|nmod|N-acetyl-S-all-trans-geranylgeranyl-l-cysteine N-acetyl-S-all-trans-geranylgeranyl-l-cysteine|appos|substrate substrate|nmod|END_ENTITY	1,10-Phenanthroline was found to inhibit the methylation of the prenylcysteine analog N-acetyl-S-all-trans-geranylgeranyl-l-cysteine , a synthetic substrate for PPMT , with an IC -LRB- 50 -RRB- of 2.2 mM .
10364476	5	1,10-Phenanthroline	482,501	Ro52	598,602	1,10-Phenanthroline	Ro52	MESH:C025205	6737	Chemical	Gene	found|nsubjpass|START_ENTITY found|xcomp|suggesting suggesting|ccomp|functional functional|nsubj|fingers fingers|nmod|END_ENTITY	1,10-Phenanthroline , a chelater of zinc , was found to inhibit this interaction , suggesting that the zinc fingers of Ro52 are functional .
25513861	0	1,10-Phenanthroline	108,127	Serum_Albumin	47,60	1,10-Phenanthroline	Serum Albumin	MESH:C025205	213	Chemical	Gene	Ligands|amod|START_ENTITY Containing|dobj|Ligands Complex|xcomp|Containing Complex|nsubj|Investigation Investigation|nmod|END_ENTITY	Investigation of the Interaction Between Human Serum_Albumin and Antitumor Palladium -LRB- II -RRB- Complex Containing 1,10-Phenanthroline and Dithiocarbamate Ligands .
28208699	0	1,10-Phenanthroline	69,88	Syndecan-4	13,23	1,10-Phenanthroline	Syndecan-4	MESH:C025205	508133(Tax:9913)	Chemical	Gene	Structure|amod|START_ENTITY Molecules|nmod|Structure END_ENTITY|nmod|Molecules	Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells .
27812033	1	1,10-phenanthroline-5-carbaldehyde	252,286	PF6	191,194	1,10-phenanthroline-5-carbaldehyde	PF6	null	200162	Chemical	Gene	1|dep|START_ENTITY END_ENTITY|dep|1	UNASSIGNED : A long-lived aldol reaction-based iridium -LRB- III -RRB- chemosensor -LSB- Ir -LRB- ppy -RRB- 2 -LRB- 5-CHOphen -RRB- -RSB- PF6 -LRB- 1 , where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde -RRB- for proline detection has been synthesized .
9485356	2	1,10-phenanthroline-copper	199,225	carbonic_anhydrase_II	284,305	1,10-phenanthroline-copper	carbonic anhydrase II	null	280740(Tax:9913)	Chemical	Gene	investigate|nmod|START_ENTITY targeted|advcl|investigate targeted|nsubjpass|sites sites|nmod|I I|conj|END_ENTITY	To investigate the mechanism of scission of proteins by the chemical cleaving agent 1,10-phenanthroline-copper , the active sites of human carbonic anydrase I and bovine carbonic_anhydrase_II have been targeted for cleavage by a tight binding sulfonamide inhibitor tethered to the metal complex .
1903535	3	1,10-phenanthroline-Cu	626,648	S1_and_T1	578,587	1,10-phenanthroline-Cu	S1 and T1	MESH:C025205	5707;921	Chemical	Gene	used|nsubjpass|START_ENTITY and/or|acl:relcl|used nucleases|dobj|and/or nucleases|nsubj|nucleases nucleases|appos|END_ENTITY	To study the P-90-RNA interaction , protein nucleases -LRB- RNase S1_and_T1 -RRB- and chemical nucleases FeEDTA and/or 1,10-phenanthroline-Cu were used as probes of an oligonucleotide -LRB- n = 55 -RRB- , containing the IRE and flanking regions -LRB- FL -RRB- , and natural ferritin mRNA .
27711752	1	1,10-phenanthrolinefuroxan	171,197	COX-2	271,276	1,10-phenanthrolinefuroxan	COX-2	null	4513	Chemical	Gene	activities|amod|START_ENTITY supported|nmod|activities supported|nmod|inhibition inhibition|nmod|pathway pathway|compound|END_ENTITY	UNASSIGNED : Zinc -LRB- ii -RRB- - NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway .
126324	2	1,10-phenanthrolines	420,440	COR1	600,604	1,10-phenanthrolines	COR1	null	20962(Tax:10090)	Chemical	Gene	joined|nsubjpass|START_ENTITY joined|nmod|form form|conj|R1CON R1CON|dep|END_ENTITY	In the first series two 1,10-phenanthrolines -LRB- R1 -RRB- were joined at the 2 position to form four compounds : R1CO-c-N -LRB- CH2CH2 -RRB- 2N-COR1 , R1CONH-1 ,2 - C6H10-NHCOR1 , R1CONH-1 ,2 - C6H4-NHCOR1 , and R1CON -LRB- CH3 -RRB- -LRB- CH2 -RRB- 2N -LRB- CH3 -RRB- COR1 .
15052735	3	1,10-phenantroline	651,669	ADH	598,601	1,10-phenantroline	ADH	null	78959(Tax:10116)	Chemical	Gene	4-methylpyrazole|conj|START_ENTITY END_ENTITY|amod|4-methylpyrazole	The aim of this investigation was to check the influence of some effective inhibitors of ADH and MEOS : 4-methylpyrazole , cimetidine , EDTA and 1,10-phenantroline on the activity of catalase with methanol as a substrate and the comparison with 3-amino-1 ,2,4 - triasole .
15052735	3	1,10-phenantroline	651,669	catalase	689,697	1,10-phenantroline	catalase	null	24248(Tax:10116)	Chemical	Gene	4-methylpyrazole|conj|START_ENTITY ADH|amod|4-methylpyrazole ADH|nmod|activity activity|nmod|END_ENTITY	The aim of this investigation was to check the influence of some effective inhibitors of ADH and MEOS : 4-methylpyrazole , cimetidine , EDTA and 1,10-phenantroline on the activity of catalase with methanol as a substrate and the comparison with 3-amino-1 ,2,4 - triasole .
15052735	9	1,10-phenantroline	1406,1424	catalase	1447,1455	1,10-phenantroline	catalase	null	24248(Tax:10116)	Chemical	Gene	4-Methylpyrazole|amod|START_ENTITY END_ENTITY|nsubj|4-Methylpyrazole	4-Methylpyrazole , EDTA , 1,10-phenantroline and aminotriasole are catalase competitive inhibitors and cimetidine is non-competitive inhibitor .
8087866	7	1,10-phenantroline	1170,1188	CD16	1258,1262	1,10-phenantroline	CD16	null	2214	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|nummod|END_ENTITY	The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding .
8087866	7	1,10-phenantroline	1170,1188	CD16	1289,1293	1,10-phenantroline	CD16	null	2214	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|acl|induced induced|nmod|crosslinking crosslinking|compound|END_ENTITY	The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding .
8087866	7	1,10-phenantroline	1170,1188	CD16	1431,1435	1,10-phenantroline	CD16	null	2214	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|downregulation downregulation|acl|induced induced|xcomp|suggesting suggesting|ccomp|requires requires|advcl|occurs occurs|nmod|PMA PMA|acl|mediated mediated|dobj|downregulation downregulation|compound|END_ENTITY	The results show that 1,10-phenantroline , a specific inhibitor of Zn -LRB- 2 + -RRB- - dependent metalloproteases , inhibits CD16 downregulation induced by CD16 crosslinking , thus suggesting that this process requires the activation of a Zn2 + dependent metalloprotease as it occurs in PMA mediated CD16 downregulation by shedding .
20582429	8	1,10-phenantroline	1540,1558	HSP70	1597,1602	1,10-phenantroline	HSP70	null	3308	Chemical	Gene	melatonin|conj|START_ENTITY Addition|dep|melatonin inhibited|nsubj|Addition inhibited|nmod|END_ENTITY	Addition of free radical scavengers -LRB- melatonin or 1,10-phenantroline -RRB- inhibited the MF-induced increase in HSP70 .
24463435	3	1,10-phenantroline	834,852	lipoxygenase	768,780	1,10-phenantroline	lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	Zn|amod|START_ENTITY exhibited|nmod|Zn tested|conj|exhibited tested|nmod|activity activity|conj|activity activity|nmod|END_ENTITY	Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with -LSB- Zn -LRB- tolf -RRB- -LRB- 1,10-phenantroline -RRB- -RSB- being the most active compound .
1560018	5	1,10-phenantroline	965,983	PLP	788,791	1,10-phenantroline	PLP	null	24943(Tax:10116)	Chemical	Gene	tetraacetic_acid|conj|START_ENTITY ethylenebis|amod|tetraacetic_acid have|nsubj|ethylenebis have|ccomp|has has|nsubj|acylesterase acylesterase|compound|END_ENTITY	The myelin-associated PLP fatty acylesterase has no apparent requirements for divalent cations -LRB- Ca2 + , Mg2 + , Mn2 + -RRB- , and chelators such as EDTA , -LSB- ethylenebis -LRB- oxyethylenenitrilo -RRB- -RSB- tetraacetic_acid , and 1,10-phenantroline have little or no effect on enzyme activity .
9540792	5	1,10-phenantroline	505,523	proteinase	544,554	1,10-phenantroline	proteinase	null	100862683	Chemical	Gene	inactivated|conj|START_ENTITY inactivated|advcl|had had|nsubj|PMSF PMSF|amod|END_ENTITY	NPS was completely inactivated with inhibitors , typical for metalloendopeptidases , EDTA and 1,10-phenantroline , whereas the serine proteinase inhibitor PMSF had no effect .
19346138	3	1,10-phenantroline	410,428	TIMP-2	458,464	1,10-phenantroline	TIMP-2	null	21858(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|conj|insusceptible insusceptible|nmod|END_ENTITY	Its activity is inhibited by 1,10-phenantroline and GM6001 , insusceptible to TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinases-2 -RRB- , and stimulated by ionomycin .
19346138	3	1,10-phenantroline	410,428	tissue_inhibitor_of_metalloproteinases-2	466,506	1,10-phenantroline	tissue inhibitor of metalloproteinases-2	null	21858(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|conj|insusceptible insusceptible|nmod|TIMP-2 TIMP-2|dep|END_ENTITY	Its activity is inhibited by 1,10-phenantroline and GM6001 , insusceptible to TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinases-2 -RRB- , and stimulated by ionomycin .
10462513	5	1,10-phenathroline	884,902	LAP	845,848	1,10-phenathroline	LAP	null	51056	Chemical	Gene	EDTA|conj|START_ENTITY activity|amod|EDTA metallo-enzyme|nmod|activity metallo-enzyme|nsubj|END_ENTITY	Gonyaulax LAP is a metallo-enzyme since EDTA and 1,10-phenathroline significantly inhibited activity .
14985069	4	1.10-phenatroline	712,729	Arginine-aminopeptidase	526,549	1.10-phenatroline	Arginine-aminopeptidase	null	81761(Tax:10116)	Chemical	Gene	arginine|conj|START_ENTITY arginine|nsubj|RESULTS RESULTS|dep|END_ENTITY	RESULTS : Arginine-aminopeptidase found in cardiac fibroblasts -LRB- Fb -RRB- was arginine and lysine specific , sensitive to various aminopeptidase -LRB- AP -RRB- inhibitors and to the inhibitor of metalloproteases , 1.10-phenatroline .
27952646	13	1,10-PM	1419,1426	MMP-7	1436,1441	1,10-PM	MMP-7	null	4316	Chemical	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	Treatment with 1,10-PM decrease MMP-7 levels -LRB- p < 0.005 -RRB- compared with untreated cells .
27952646	7	1,10-PM	932,939	MMP-7	883,888	1,10-PM	MMP-7	null	4316	Chemical	Gene	monohydrate|appos|START_ENTITY monohydrate|amod|inhibitor inhibitor|amod|END_ENTITY	Both cell lines were cultured for 72h with different concentrations of oxaliplatin , BAY11-7085 -LRB- inhibitor of NF-kB activation -RRB- , 0.01 mM of the MMP-7 inhibitor 1,10-Phenanthroline _ monohydrate -LRB- 1,10-PM -RRB- and 100 ng/ml of DX2 monoclonal antibody .
25343522	10	1,10-PT	1494,1501	Bcl-xL	1526,1532	1,10-PT	Bcl-xL	null	598	Chemical	Gene	blocked|nsubj|START_ENTITY blocked|dobj|cleavage cleavage|nmod|END_ENTITY	Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels .
25343522	10	1,10-PT	1494,1501	Bim	1712,1715	1,10-PT	Bim	null	10018	Chemical	Gene	blocked|nsubj|START_ENTITY blocked|conj|increased increased|dobj|levels levels|nmod|Bcl-xL/Bim Bcl-xL/Bim|conj|complexes complexes|compound|END_ENTITY	Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels .
25343522	10	1,10-PT	1494,1501	Mcl-1	1534,1539	1,10-PT	Mcl-1	null	4170	Chemical	Gene	blocked|nsubj|START_ENTITY blocked|dobj|cleavage cleavage|nmod|Bcl-xL Bcl-xL|conj|END_ENTITY	Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels .
25343522	10	1,10-PT	1494,1501	Mcl-1	1706,1711	1,10-PT	Mcl-1	null	4170	Chemical	Gene	blocked|nsubj|START_ENTITY blocked|conj|increased increased|dobj|levels levels|nmod|Bcl-xL/Bim Bcl-xL/Bim|conj|complexes complexes|compound|END_ENTITY	Furthermore , the 1,10-PT blocked the cleavage of Bcl-xL , Mcl-1 , PARP , caspase-3 , and caspase-9 , as well as the release of cytochrome c into the cytosol , and it significantly increased the association levels of the Bcl-xL/Bim and Mcl-1 / Bim protein complexes , returning them to normal levels .
22465714	2	1-111_amino_acids	369,386	b-catenin	302,311	1-111 amino acids	b-catenin	null	1499	Chemical	Gene	mapped|nmod|START_ENTITY mapped|nsubjpass|domain domain|amod|END_ENTITY	The minimum b-catenin binding domain of p300 has been mapped to the N-terminus 1-111_amino_acids .
22465714	2	1-111_amino_acids	369,386	p300	330,334	1-111 amino acids	p300	null	2033	Chemical	Gene	mapped|nmod|START_ENTITY mapped|nsubjpass|domain domain|nmod|END_ENTITY	The minimum b-catenin binding domain of p300 has been mapped to the N-terminus 1-111_amino_acids .
27919363	10	11-11-deoxycortisol	2047,2066	LDL-C	1968,1973	11-11-deoxycortisol	LDL-C	null	22796	Chemical	Gene	dehydroepiandrostenedione|conj|START_ENTITY values|amod|dehydroepiandrostenedione change|nsubj|values decreased|advcl|change decreased|nmod|conjunction conjunction|nmod|levels levels|nmod|END_ENTITY	However , peak TT and FT hormone levels decreased in conjunction with decreasing levels of LDL-C among the statin-treated patients , whereas dehydroepiandrostenedione and 11-11-deoxycortisol peak values did not change .
23249676	2	11,12,15-THETA	405,419	15-lipoxygenase	456,471	11,12,15-THETA	15-lipoxygenase	null	246	Chemical	Gene	metabolites|nsubj|START_ENTITY metabolites|nmod|pathway pathway|amod|END_ENTITY	15 -LRB- S -RRB- - Hydroxy-11 ,12 - epoxyeicosatrienoic_acid -LRB- 15-H-11 ,12 - EETA -RRB- and 11 -LRB- R -RRB- ,12 -LRB- S -RRB- ,15 -LRB- S -RRB- - trihydroxyeicosatrienoic_acid -LRB- 11,12,15-THETA -RRB- are endothelial metabolites of the 15-lipoxygenase -LRB- 15-LO -RRB- pathway of arachidonic_acid metabolism and are EDHFs .
23186146	6	1,1,1,2,2-pentaphenylethane	1217,1244	Ph3E	1164,1168	1,1,1,2,2-pentaphenylethane	Ph3E	null	10338	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis .
23706493	4	11-12AA	715,722	MYG1	677,681	11-12AA	MYG1	null	60314	Chemical	Gene	polymorphisms|nummod|START_ENTITY promoter|conj|polymorphisms promoter|nummod|END_ENTITY	METHODS : Polymerase chain reaction-restriction fragment length polymorphism -LRB- PCR-RFLP -RRB- technique was used for genotyping of MYG1 -119 C/G promoter -LRB- rs1465073 -RRB- and 11-12AA / GC structural polymorphisms -LRB- rs1534284-rs1534283 ; Arg4Gln -RRB- in 846 vitiligo patients and 726 age-matched unaffected controls .
23706493	7	11-12AA	1099,1106	MYG1	1195,1199	11-12AA	MYG1	null	60314	Chemical	Gene	polymorphism|nummod|START_ENTITY monogenic|nsubj|polymorphism monogenic|nmod|allele allele|nummod|END_ENTITY	However , 11-12AA / GC structural polymorphism was prevalently monogenic in patients and controls with only MYG1 GC -LRB- 4Arg -RRB- allele being present .
1742324	9	11,12-alpha-ketol	1903,1920	SN1	1712,1715	11,12-alpha-ketol	SN1	null	10991	Chemical	Gene	gamma-ketol|conj|START_ENTITY affording|xcomp|gamma-ketol 12,13-alpha-ketol|acl|affording formation|nmod|12,13-alpha-ketol resulting|nmod|formation nucleophilic|advcl|resulting nucleophilic|parataxis|group group|nsubj|SN2 SN2|conj|OH OH|compound|END_ENTITY	Two distinct mechanisms of allene_oxide hydrolysis are proposed : -LRB- 1 -RRB- nucleophilic -LRB- SN2 or SN1 , OH - is an attacking group -RRB- substitution , resulting in formation of 12,13-alpha-ketol ; -LRB- 2 -RRB- electrophilic -LRB- SE-like -RRB- reaction initiated by protonation of oxirane , affording gamma-ketol and 11,12-alpha-ketol .
1742324	9	11,12-alpha-ketol	1903,1920	SN2	1705,1708	11,12-alpha-ketol	SN2	null	92745	Chemical	Gene	gamma-ketol|conj|START_ENTITY affording|xcomp|gamma-ketol 12,13-alpha-ketol|acl|affording formation|nmod|12,13-alpha-ketol resulting|nmod|formation nucleophilic|advcl|resulting nucleophilic|parataxis|group group|nsubj|END_ENTITY	Two distinct mechanisms of allene_oxide hydrolysis are proposed : -LRB- 1 -RRB- nucleophilic -LRB- SN2 or SN1 , OH - is an attacking group -RRB- substitution , resulting in formation of 12,13-alpha-ketol ; -LRB- 2 -RRB- electrophilic -LRB- SE-like -RRB- reaction initiated by protonation of oxirane , affording gamma-ketol and 11,12-alpha-ketol .
8384875	2	11-12-amino_acid	276,292	c-Fms	491,496	11-12-amino acid	c-Fms	null	1436	Chemical	Gene	phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|END_ENTITY	Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind .
8384875	2	11-12-amino_acid	276,292	CSF-1	485,490	11-12-amino acid	CSF-1	null	1435	Chemical	Gene	phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|c-Fms c-Fms|compound|END_ENTITY	Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind .
8384875	2	11-12-amino_acid	276,292	IRS-1	525,530	11-12-amino acid	IRS-1	null	3667	Chemical	Gene	phosphopeptides|amod|START_ENTITY bound|nsubj|phosphopeptides bound|nmod|sequences sequences|acl|surrounding surrounding|dobj|tyrosines tyrosines|nmod|PDGF PDGF|conj|END_ENTITY	Eleven synthetic 11-12-amino_acid phosphopeptides containing YMXM or YVXM recognition motifs bound to a PI 3-kinase p85 SH2 domain with highest affinities , including sequences surrounding phosphorylated tyrosines of the PDGF , CSF-1 / c-Fms , and kit-encoded receptors , IRS-1 , and polyoma middle T antigens ; matched , unphosphorylated sequences did not bind .
10822532	3	11,12-cyclopropylretinal	376,400	rhodopsin	316,325	11,12-cyclopropylretinal	rhodopsin	MESH:C050233	509933(Tax:9913)	Chemical	Gene	analogues|amod|START_ENTITY studies|nmod|analogues determined|nmod|studies determined|nsubjpass|twist twist|nmod|bond bond|nmod|chromophore chromophore|nmod|END_ENTITY	The absolute twist around the 12-s bond of the chromophore in rhodopsin has been determined by studies with 11-cis-locked 11,12-cyclopropylretinal analogues -LRB- 11S ,12 R -RRB- -2 and -LRB- 11R ,12 S -RRB- -3 , enantioselectively synthesized with the aid of an enzyme .
17885841	1	11,12-dehydrofalcarinol	277,300	Bean	197,201	11,12-dehydrofalcarinol	Bean	null	146227	Chemical	Gene	polyacetylenes|conj|START_ENTITY known|xcomp|polyacetylenes two|acl|known isolated|nmod|two isolated|nmod|extract extract|nmod|galls galls|nmod|END_ENTITY	A new C -LRB- 17 -RRB- - polyacetylene , named hederyne_A -LRB- 1 -RRB- , has been isolated from the MeOH extract of galls of Hedera rhombea Bean -LRB- Araliaceae -RRB- , together with two known polyacetylenes , falcarindiol -LRB- 2 -RRB- and 11,12-dehydrofalcarinol -LRB- 3 -RRB- .
18805895	7	11,12-DHET	1994,2004	A2A_AR	2044,2050	11,12-DHET	A2A AR	CHEBI:63969	11540(Tax:10090)	Chemical	Gene	14,15-DHET|nummod|START_ENTITY DHETs|dep|14,15-DHET dihydroxyeicosatrienoic_acids|dep|DHETs levels|nmod|dihydroxyeicosatrienoic_acids found|nsubjpass|levels found|nmod|+ +|compound|END_ENTITY	Higher levels of dihydroxyeicosatrienoic_acids -LRB- DHETs ; 14,15-DHET , 11,12-DHET , and 8,9-DHET , P < 0.05 -RRB- were found in A2A_AR + / + versus A2A_AR -LRB- - / - -RRB- aortae .
18805895	7	11,12-DHET	1994,2004	A2A_AR	2061,2067	11,12-DHET	A2A AR	CHEBI:63969	11540(Tax:10090)	Chemical	Gene	14,15-DHET|nummod|START_ENTITY DHETs|dep|14,15-DHET dihydroxyeicosatrienoic_acids|dep|DHETs levels|nmod|dihydroxyeicosatrienoic_acids found|nsubjpass|levels found|nmod|+ +|nmod|aortae aortae|compound|END_ENTITY	Higher levels of dihydroxyeicosatrienoic_acids -LRB- DHETs ; 14,15-DHET , 11,12-DHET , and 8,9-DHET , P < 0.05 -RRB- were found in A2A_AR + / + versus A2A_AR -LRB- - / - -RRB- aortae .
11483698	15	11,12-DHET	1688,1698	BK_channel	1713,1723	11,12-DHET	BK channel	CHEBI:63969	83731(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|conductance conductance|amod|END_ENTITY	Single channel kinetic analysis indicated that 11,12-DHET did not alter BK_channel conductance but did reduce the first latency of BK_channel openings in response to a voltage step .
11483698	15	11,12-DHET	1688,1698	BK_channel	1772,1782	11,12-DHET	BK channel	CHEBI:63969	83731(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|conj|reduce reduce|dobj|latency latency|nmod|openings openings|compound|END_ENTITY	Single channel kinetic analysis indicated that 11,12-DHET did not alter BK_channel conductance but did reduce the first latency of BK_channel openings in response to a voltage step .
27663770	11	11,12-DHET	1698,1708	CYP2C19	1593,1600	11,12-DHET	CYP2C19	CHEBI:63969	1557	Chemical	Gene	were|dep|START_ENTITY were|nsubj|levels levels|nmod|PM PM|compound|END_ENTITY	In MVA group , DHET levels for CYP2C19 PM were significantly lower than that of non-PM -LSB- 10.9 1.64 vs. 14.2 5.39 ng/ml , P = 0.019 -LRB- 11,12-DHET -RRB- ; 15.2 4.39 vs. 17.9 4.73 ng/ml , P = 0.025 -LRB- 14,15-DHET -RRB- -RSB- .
28616567	9	11,12-DHET	1431,1441	CYP2C19	1319,1326	11,12-DHET	CYP2C19	CHEBI:63969	1557	Chemical	Gene	P|appos|START_ENTITY 4.58|appos|P non-PM|dep|4.58 that|nmod|non-PM lower|nmod|that lower|nsubj|levels levels|nmod|PM PM|compound|END_ENTITY	Moreover , DHET levels in CYP2C19 PM were significantly lower than that of non-PM -LRB- 10.4 4.58 vs. 15.6 11.1 ng/mL , P = 0.003 -LRB- 11,12-DHET -RRB- ; 12.1 3.79 vs. 17.3 6.49 ng/mL , P = 0.019 -LRB- 14,15-DHET -RRB- -RRB- .
22678950	4	11,12-diesters	988,1002	C-11	1083,1087	11,12-diesters	C-11	null	51728	Chemical	Gene	ions|nmod|START_ENTITY dissociation|nmod|ions revealed|nsubj|dissociation revealed|dobj|losses losses|nmod|first first|nmod|END_ENTITY	Sequential in-trap collision-induced dissociation of -LSB- M + Na -RSB- -LRB- + -RRB- ions from 11,12-diesters revealed consistent preferred losses of substituents first from C-12 , then from C-11 , followed by losses of monosaccharide fragments from the C-3_tri - _ and_tetrasaccharide substituents .
2546405	4	11,12-diHETE	578,590	glutathione_S-transferase	531,556	11,12-diHETE	glutathione S-transferase	MESH:C410128	58962(Tax:10116)	Chemical	Gene	gland|amod|START_ENTITY isomer|nmod|gland END_ENTITY|conj|isomer	In addition to the above nonenzymic products , 11,12-LTA4 was converted to 11,12-LTC4 by the rat liver glutathione_S-transferase , and to an isomer of 11,12-diHETE by homogenates of the guinea_pig adrenal gland and liver .
9348439	4	11,12-dihydrodiol	1322,1339	CD-1	1159,1163	11,12-dihydrodiol	CD-1	null	25109(Tax:10116)	Chemical	Gene	enantiomers|amod|START_ENTITY configuration|nmod|enantiomers depends|nmod|configuration depends|ccomp|revealed revealed|nsubj|Incubations Incubations|nmod|microsomes microsomes|conj|mice mice|compound|END_ENTITY	Incubations with liver microsomes of Sprague-Dawley_rats and CD-1 mice pretreated with Aroclor_1254 revealed that the enzymatic conversion to the fjord region DB -LSB- a , l -RSB- PDE strongly depends on the absolute configuration of the 11,12-dihydrodiol enantiomers .
15223354	3	11,12-dihydrodiol	735,752	DBP	507,510	11,12-dihydrodiol	DBP	MESH:C529145	13170(Tax:10090)	Chemical	Gene	derivative|dep|START_ENTITY formed|dobj|derivative discussed|ccomp|formed discussed|nmod|metabolites metabolites|nmod|END_ENTITY	As ultimate genotoxic metabolites of DBP two electrophilically reactive species are discussed : -LRB- i -RRB- radical cations generated by one-electron oxidation , and -LRB- ii -RRB- fjord region dihydrodiol_epoxides formed via the trans-11 ,12 - dihydroxy 11,12-dihydro derivative of DBP -LRB- 11,12-dihydrodiol -RRB- .
15223354	3	11,12-dihydrodiol	735,752	DBP	730,733	11,12-dihydrodiol	DBP	MESH:C529145	13170(Tax:10090)	Chemical	Gene	derivative|dep|START_ENTITY derivative|nmod|END_ENTITY	As ultimate genotoxic metabolites of DBP two electrophilically reactive species are discussed : -LRB- i -RRB- radical cations generated by one-electron oxidation , and -LRB- ii -RRB- fjord region dihydrodiol_epoxides formed via the trans-11 ,12 - dihydroxy 11,12-dihydro derivative of DBP -LRB- 11,12-dihydrodiol -RRB- .
7910485	3	11,12-EET	613,622	2B1	516,519	11,12-EET	2B1	MESH:C046783	286954(Tax:10116)	Chemical	Gene	produced|dobj|START_ENTITY acid|dep|produced produced|nsubj|acid produced|dep|P-450 P-450|dep|END_ENTITY	P-450 2B1 produced predominantly 14,15-epoxyeicosatrienoic _ acid -LRB- EET -RRB- , while P-450 2B1-WM produced the 11,12-EET as the major product .
19401302	8	11,12-EET	1430,1439	Akt	1381,1384	11,12-EET	Akt	MESH:C046783	11651(Tax:10090)	Chemical	Gene	perfused|nmod|START_ENTITY hearts|acl|perfused found|nmod|hearts found|nsubjpass|expression expression|nmod|epsilon epsilon|conj|END_ENTITY	Increased expression of phosphorylated protein kinase C epsilon and Akt were found in WT hearts perfused with either 11,12-EET or rBNP , while mitochondrial glycogen synthase kinase-3beta was significantly lower in the same samples .
28587983	6	11,12-EET	923,932	Ang	980,983	11,12-EET	Ang	MESH:C046783	283	Chemical	Gene	treatment|nmod|START_ENTITY attenuated|nsubj|treatment attenuated|dobj|inflammation inflammation|acl|induced induced|nmod|II II|compound|END_ENTITY	Furthermore , treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-kB nuclear translocation , increased IkBa expression and decreased_inflammation factor level .
28554983	7	11,12-EET	1232,1241	Ang_II	1126,1132	11,12-EET	Ang II	MESH:C046783	11606(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY pathway|acl:relcl|inhibited activation|nmod|pathway associated|nmod|activation associated|nsubjpass|activation activation|acl|induced induced|nmod|END_ENTITY	In in vitro studies , cardiac fibroblast activation , proliferation , migration , and collagen production induced by Ang_II were associated with activation of the Ga12/13/RhoA / ROCK pathway , which was inhibited by exogenous 11,12-EET .
21846841	5	11,12-EET	791,800	caspase-3	913,922	11,12-EET	caspase-3	MESH:C046783	836	Chemical	Gene	prevented|nsubj|START_ENTITY prevented|dobj|activation activation|amod|kinase kinase|conj|END_ENTITY	11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase , c-Jun NH -LRB- 2 -RRB- - terminal kinase , caspase-3 , and caspase-9 .
21846841	5	11,12-EET	791,800	caspase-9	928,937	11,12-EET	caspase-9	MESH:C046783	842	Chemical	Gene	prevented|nsubj|START_ENTITY prevented|dobj|activation activation|amod|kinase kinase|conj|END_ENTITY	11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase , c-Jun NH -LRB- 2 -RRB- - terminal kinase , caspase-3 , and caspase-9 .
21846841	4	11,12-EET	649,658	catalase	745,753	11,12-EET	catalase	MESH:C046783	847	Chemical	Gene	pretreatment|nummod|START_ENTITY increased|nsubj|pretreatment increased|dobj|expression expression|nmod|superoxide superoxide|amod|dismutase dismutase|conj|END_ENTITY	11,12-EET pretreatment increased expression of the antioxidant enzymes superoxide dismutase and catalase and inhibited ATO-induced apoptosis .
15652503	1	11,12-EET	220,229	CYP2C	137,142	11,12-EET	CYP2C	MESH:C046783	1559	Chemical	Gene	oxidized|nmod|START_ENTITY oxidized|nmod|cytochromes_P450_2C cytochromes_P450_2C|appos|END_ENTITY	Arachidonic_acid is oxidized by cytochromes_P450_2C -LRB- CYP2C -RRB- to epoxyeicosatrienoic_acids -LRB- EETs -RRB- , possessing vasoactive properties , with 11,12-EET as the endothelium derived hyperpolarization factor .
19073823	3	11,12-EET	604,613	CYP2C23	535,542	11,12-EET	CYP2C23	MESH:C046783	83790(Tax:10116)	Chemical	Gene	levels|appos|START_ENTITY increased|dobj|levels stimulated|conj|increased stimulated|dobj|expression expression|nmod|END_ENTITY	By Western blot analysis , high dietary K stimulated the expression of CYP2C23 but not CYP2J2 and increased 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- levels in isolated rat CCD tubules .
17872452	7	11,12-EET	1428,1437	CYP2C9	1242,1248	11,12-EET	CYP2C9	MESH:C046783	1559	Chemical	Gene	mimicked|nmod|START_ENTITY prevented|conj|mimicked membrane|acl:relcl|prevented areas|nmod|membrane enhanced|nmod|areas enhanced|nsubj|overexpression overexpression|nmod|END_ENTITY	Indeed , overexpression of CYP2C9 enhanced the agonist-induced translocation of a TrpC6-V5 fusion protein to caveolin-1-rich areas of the endothelial cell membrane , which was prevented by Rp-cAMPS and mimicked by 11,12-EET .
19073823	3	11,12-EET	604,613	CYP2J2	551,557	11,12-EET	CYP2J2	MESH:C046783	65210(Tax:10116)	Chemical	Gene	levels|appos|START_ENTITY increased|dobj|levels stimulated|conj|increased stimulated|dobj|expression expression|nmod|CYP2C23 CYP2C23|conj|END_ENTITY	By Western blot analysis , high dietary K stimulated the expression of CYP2C23 but not CYP2J2 and increased 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- levels in isolated rat CCD tubules .
24058654	0	11,12-EET	33,42	CYP2J2	10,16	11,12-EET	CYP2J2	MESH:C046783	1573	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis : a role for CYP2J2_deficiency in the pathogenesis of Crohn 's _ disease ?
24058654	6	11,12-EET	645,654	CYP2J2	612,618	11,12-EET	CYP2J2	MESH:C046783	1573	Chemical	Gene	products|nummod|START_ENTITY arachidonic_acid|dobj|products arachidonic_acid|nsubj|END_ENTITY	The CYP2J2 arachidonic_acid products 11,12-EET and 14,15-EET inhibited LPS induced TNFa release .
24058654	8	11,12-EET	999,1008	CYP2J2	889,895	11,12-EET	CYP2J2	MESH:C046783	1573	Chemical	Gene	reversed|nmod|START_ENTITY phagocytosis|acl:relcl|reversed inhibitor|dobj|phagocytosis inhibitor|nsubj|inhibition inhibition|acl|using using|dobj|SKF525A SKF525A|conj|END_ENTITY	Epoxygenase inhibition using a non-selective inhibitor SKF525A or a selective CYP2J2 inhibitor Compound 4 , inhibited E. _ coli particle phagocytosis , which could be specifically reversed by 11,12-EET .
24486707	5	11,12-EET	977,986	CYP2J4	951,957	11,12-EET	CYP2J4	MESH:C046783	65210(Tax:10116)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|expression expression|nmod|END_ENTITY	In addition , the ox-LDL-induced expression of CYP2J4 was upregulated by 11,12-EET and 14,15-EET -LRB- 1 M -RRB- .
12124379	5	11,12-EET	1044,1053	CYP4A2	1007,1013	11,12-EET	CYP4A2	MESH:C046783	1579	Chemical	Gene	preferred|dobj|START_ENTITY preferred|nsubj|END_ENTITY	CYP4A1 exhibited a preference for 8,9-EET , whereas CYP4A2 , CYP4A3 , and CYP4A8 preferred 11,12-EET .
16141533	2	11,12-EET	748,757	CYP4A2	762,768	11,12-EET	CYP4A2	MESH:C046783	1579	Chemical	Gene	eicosatrienoic_acid|appos|START_ENTITY eicosatrienoic_acid|nmod|END_ENTITY	The IC50 value for production of 11,12-epoxy-5 ,8,14 - eicosatrienoic_acid -LRB- 11,12-EET -RRB- by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM , respectively .
12876297	1	11,12-EET	255,264	Cytochrome_P-450_monooxygenase	125,155	11,12-EET	Cytochrome P-450 monooxygenase	MESH:C046783	313375(Tax:10116)	Chemical	Gene	acid|appos|START_ENTITY metabolites|nmod|acid possess|nsubj|metabolites arachidonic_acid|acl:relcl|possess END_ENTITY|dep|arachidonic_acid	Cytochrome_P-450_monooxygenase -LRB- epoxygenase -RRB- - derived arachidonic_acid -LRB- AA -RRB- metabolites , including 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- , possess anti-inflammatory and antipyretic properties .
15652503	1	11,12-EET	220,229	cytochromes_P450_2C	116,135	11,12-EET	cytochromes P450 2C	MESH:C046783	1559	Chemical	Gene	oxidized|nmod|START_ENTITY oxidized|nmod|END_ENTITY	Arachidonic_acid is oxidized by cytochromes_P450_2C -LRB- CYP2C -RRB- to epoxyeicosatrienoic_acids -LRB- EETs -RRB- , possessing vasoactive properties , with 11,12-EET as the endothelium derived hyperpolarization factor .
16234312	13	11,12-EET	1687,1696	ENaC	1707,1711	11,12-EET	ENaC	MESH:C046783	24768(Tax:10116)	Chemical	Gene	acid|appos|START_ENTITY inhibits|nsubj|acid inhibits|dobj|activity activity|amod|END_ENTITY	Because 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- inhibits ENaC activity in the CCD -LRB- Wei Y , Lin DH , Kemp R , Yaddanapudi GSS , Nasjletti A , Falck JR , and Wang WH .
16234312	14	11,12-EET	1868,1877	ENaC	1918,1922	11,12-EET	ENaC	MESH:C046783	24768(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY examined|dobj|role examined|advcl|mediating mediating|nmod|END_ENTITY	J Gen Physiol 124 : 719-727 , 2004 -RRB- , we examined the role of 11,12-EET in mediating the effect of adenosine on ENaC .
16234312	15	11,12-EET	1936,1945	ENaC	1956,1960	11,12-EET	ENaC	MESH:C046783	24768(Tax:10116)	Chemical	Gene	Addition|nmod|START_ENTITY inhibited|nsubj|Addition inhibited|dobj|channels channels|amod|END_ENTITY	Addition of 11,12-EET inhibited ENaC channels in the CCD in which adenosine-induced inhibition was blocked by AACOCF3 .
16234312	16	11,12-EET	2198,2207	ENaC	2079,2083	11,12-EET	ENaC	MESH:C046783	24768(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY inhibits|conj|mediated inhibits|dobj|activity activity|amod|END_ENTITY	We conclude that adenosine inhibits ENaC activity by stimulation of the A -LRB- 1 -RRB- adenosine receptor in the CCD and that the effect of adenosine is mediated by 11,12-EET .
18340006	3	11,12-EET	521,530	EphB4	575,580	11,12-EET	EphB4	MESH:C046783	13846(Tax:10090)	Chemical	Gene	time-dependently|compound|START_ENTITY stimulation|nmod|time-dependently overexpression|conj|stimulation increased|nsubj|overexpression increased|dobj|expression expression|amod|END_ENTITY	METHODS AND RESULTS : CYP2C9 overexpression as well as stimulation with 11,12-EET -LRB- up to 48 hours -RRB- time-dependently increased EphB4 expression in endothelial cells .
11510882	6	11,12-EET	1370,1379	Erk1/2	1414,1420	11,12-EET	Erk1/2	MESH:C046783	5595;5594	Chemical	Gene	product|appos|START_ENTITY activated|nsubj|product activated|dobj|kinases kinases|conj|END_ENTITY	The CYP 2C product 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- also activated tyrosine kinases , Erk1/2 and p38_MAP_kinase .
24486707	4	11,12-EET	686,695	E-selectin	809,819	11,12-EET	E-selectin	MESH:C046783	25544(Tax:10116)	Chemical	Gene	pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|conj|END_ENTITY	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner .
27966642	4	11,12-EET	572,581	ICAM1	846,851	11,12-EET	ICAM1	MESH:C046783	3383	Chemical	Gene	addition|nmod|START_ENTITY addition|dep|product product|nmod|hydrolysis hydrolysis|conj|expression expression|nummod|END_ENTITY	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression .
24486707	4	11,12-EET	686,695	ICAM-1	800,806	11,12-EET	ICAM-1	MESH:C046783	25464(Tax:10116)	Chemical	Gene	pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|dep|END_ENTITY	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner .
27966642	4	11,12-EET	572,581	ICAM-1	725,731	11,12-EET	ICAM-1	MESH:C046783	3383	Chemical	Gene	addition|nmod|START_ENTITY addition|acl:relcl|dodecanoic_acid dodecanoic_acid|ccomp|inhibited inhibited|dobj|expression expression|amod|VCAM-1 VCAM-1|conj|END_ENTITY	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression .
28587983	6	11,12-EET	923,932	IkBa	1052,1056	11,12-EET	IkBa	MESH:C046783	4792	Chemical	Gene	treatment|nmod|START_ENTITY attenuated|nsubj|treatment attenuated|dobj|inflammation inflammation|acl|induced induced|advcl|evidenced evidenced|nmod|translocation translocation|conj|expression expression|amod|END_ENTITY	Furthermore , treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-kB nuclear translocation , increased IkBa expression and decreased_inflammation factor level .
24486707	4	11,12-EET	686,695	intercellular_adhesion_molecule-1	765,798	11,12-EET	intercellular adhesion molecule-1	MESH:C046783	25464(Tax:10116)	Chemical	Gene	pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|END_ENTITY	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner .
24486707	4	11,12-EET	686,695	MCP-1	861,866	11,12-EET	MCP-1	MESH:C046783	24770(Tax:10116)	Chemical	Gene	pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|appos|END_ENTITY	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner .
28319086	9	11,12-EET	992,1001	MMP-9	1150,1155	11,12-EET	MMP-9	MESH:C046783	17395(Tax:10090)	Chemical	Gene	treatment|nummod|START_ENTITY decreased|nsubj|treatment decreased|advcl|resulting resulting|nmod|production production|nmod|cytokines cytokines|conj|expression expression|compound|END_ENTITY	11,12-EET treatment decreased neutrophil and macrophage infiltration to the wound sites , resulting in reduced production of inflammatory cytokines , decreased MMP-9 expression , and increased collagen accumulation in the granulation tissues of ob/ob mice .
24486707	4	11,12-EET	686,695	monocyte_chemoattractant_protein-1	825,859	11,12-EET	monocyte chemoattractant protein-1	MESH:C046783	24770(Tax:10116)	Chemical	Gene	pre-treatment|nmod|START_ENTITY attenuated|nsubj|pre-treatment attenuated|dobj|expression expression|acl|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|conj|END_ENTITY	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , E-selectin , and monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in a concentration-dependent manner .
24486707	8	11,12-EET	1375,1384	NF-kB	1459,1464	11,12-EET	NF-kB	MESH:C046783	309165(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|conj|activation activation|nmod|END_ENTITY	In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 .
23029390	7	11,12-EET	1312,1321	NOS	1236,1239	11,12-EET	NOS	MESH:C046783	18125(Tax:10090)	Chemical	Gene	induced|nummod|START_ENTITY depolarization|nmod:npmod|induced channels|amod|depolarization dye|appos|channels loaded|nmod|dye inhibitors|conj|loaded inhibitors|nsubj|cells cells|acl|treated treated|nmod|END_ENTITY	In pulmonary artery smooth muscle cells treated with NOS and COX inhibitors and loaded with the potentiometric dye , di-8-ANEPPS , 11,12-EET induced depolarization while the BK channel opener NS1619 elicited hyperpolarization indicating there was no effect of the EET on classical plasma membrane BK channels .
24486707	8	11,12-EET	1375,1384	p38	1415,1418	11,12-EET	p38	MESH:C046783	81649(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 .
11510882	6	11,12-EET	1370,1379	p38_MAP_kinase	1425,1439	11,12-EET	p38 MAP kinase	MESH:C046783	1432	Chemical	Gene	product|appos|START_ENTITY activated|nsubj|product activated|dobj|kinases kinases|conj|END_ENTITY	The CYP 2C product 11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- also activated tyrosine kinases , Erk1/2 and p38_MAP_kinase .
24486707	8	11,12-EET	1375,1384	p65	1466,1469	11,12-EET	p65	MESH:C046783	25716(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|phosphorylation phosphorylation|conj|activation activation|nmod|NF-kB NF-kB|appos|END_ENTITY	In addition , we confirmed that 11,12-EET suppresses phosphorylation of p38 , degradation of IkBa , and activation of NF-kB -LRB- p65 -RRB- , whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2 .
28554983	8	11,12-EET	1309,1318	RhoA	1277,1281	11,12-EET	RhoA	MESH:C046783	11848(Tax:10090)	Chemical	Gene	exerted|nmod|START_ENTITY exerted|nsubj|silencing silencing|nmod|Ga12/13 Ga12/13|conj|END_ENTITY	Moreover , silencing of Ga12/13 or RhoA exerted similar effects as 11,12-EET .
26201599	4	11,12-EET	708,717	runx1	800,805	11,12-EET	runx1	MESH:C046783	58126(Tax:7955)	Chemical	Gene	promoted|nsubj|START_ENTITY promoted|advcl|activating activating|xcomp|autonomous autonomous|nsubj|AP-1 AP-1|conj|program program|amod|END_ENTITY	The pro-haematopoietic effects of EETs were conserved in the developing zebrafish embryo , where 11,12-EET promoted HSPC specification by activating a unique activator protein 1 -LRB- AP-1 -RRB- and runx1 transcription program autonomous to the haemogenic endothelium .
20595684	10	11,12-EET	1682,1691	sEH	1754,1757	11,12-EET	sEH	MESH:C046783	65030(Tax:10116)	Chemical	Gene	effect|conj|START_ENTITY enhances|dobj|effect enhances|nmod|activity activity|conj|activity activity|compound|END_ENTITY	In conclusion , high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity , respectively .
27079253	5	11,12-EET	855,864	sEH	833,836	11,12-EET	sEH	MESH:C046783	2053	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|advcl|stabilized stabilized|nmod|inhibitor inhibitor|compound|END_ENTITY	APPROACH/RESULTS : When stabilized by an sEH inhibitor -LRB- seHi -RRB- , 11,12-EET at a physiologically low dose -LRB- 0.1 nM -RRB- reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells -LRB- HAEC -RRB- and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFa .
28488585	4	11,12-EET	814,823	sEH	791,794	11,12-EET	sEH	MESH:C046783	13850(Tax:10090)	Chemical	Gene	AUDA|conj|START_ENTITY AUDA|compound|END_ENTITY	In addition , sEH inhibitor AUDA and 11,12-EET also decreased endothelial hyper-permeability in the in-vitro study .
28881620	4	11,12-EET	814,823	sEH	791,794	11,12-EET	sEH	MESH:C046783	13850(Tax:10090)	Chemical	Gene	AUDA|conj|START_ENTITY AUDA|compound|END_ENTITY	In addition , sEH inhibitor AUDA and 11,12-EET also decreased endothelial hyper-permeability in the in-vitro study .
25618409	9	11,12-EET	1638,1647	TGF-b1	1696,1702	11,12-EET	TGF-b1	MESH:C046783	21803(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY cardiomyocytes|acl|treated media|nmod|cardiomyocytes inhibited|nsubj|media inhibited|dobj|activation activation|nmod|fibroblasts fibroblasts|conj|/ /|compound|END_ENTITY	Furthermore , conditioned media from neonatal cardiomyocytes treated with 11,12-EET inhibited activation of cardiac fibroblasts and TGF-b1 / smad pathway .
27079253	5	11,12-EET	855,864	TNFa	1106,1110	11,12-EET	TNFa	MESH:C046783	7124	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|advcl|combined combined|nmod|END_ENTITY	APPROACH/RESULTS : When stabilized by an sEH inhibitor -LRB- seHi -RRB- , 11,12-EET at a physiologically low dose -LRB- 0.1 nM -RRB- reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells -LRB- HAEC -RRB- and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFa .
20163540	6	11,12-EET	1053,1062	TRPV4	1131,1136	11,12-EET	TRPV4	MESH:C046783	66026(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY prevented|nsubjpass|effect prevented|nmod|blockade blockade|conj|blockade blockade|nmod|END_ENTITY	The beneficial effect of 11,12-EET was not prevented by blockade of K -LRB- ATP -RRB- channels nor by blockade of TRPV4 .
27966642	4	11,12-EET	572,581	VCAM1	836,841	11,12-EET	VCAM1	MESH:C046783	7412	Chemical	Gene	addition|nmod|START_ENTITY addition|dep|product product|nmod|hydrolysis hydrolysis|conj|END_ENTITY	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression .
14592496	0	11,12-EET	32,41	VCAM-1	104,110	11,12-EET	VCAM-1	MESH:C046783	7412	Chemical	Gene	acid|appos|START_ENTITY acid|dep|determinants determinants|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	11,12-epoxyeicosatrienoic _ acid -LRB- 11,12-EET -RRB- : structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression .
27966642	4	11,12-EET	572,581	VCAM-1	714,720	11,12-EET	VCAM-1	MESH:C046783	7412	Chemical	Gene	addition|nmod|START_ENTITY addition|acl:relcl|dodecanoic_acid dodecanoic_acid|ccomp|inhibited inhibited|dobj|expression expression|amod|END_ENTITY	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12 - -LRB- 3-adamantane-1-yl-ureido -RRB- - dodecanoic_acid -LRB- AUDA -RRB- , an inhibitor of epoxide hydrolysis , inhibited VCAM-1 and ICAM-1 expression and protein levels ; conversely the diol product of 19,20-EDP hydrolysis , 19,20-DHDP , induced VCAM1 and ICAM1 expression .
16439348	2	11,12-epoxy	614,625	C-4	639,642	11,12-epoxy	C-4	null	720	Chemical	Gene	taxoids|amod|START_ENTITY taxoids|nmod|bond bond|compound|END_ENTITY	Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata .
2546405	4	11,12-LTC4	503,513	glutathione_S-transferase	531,556	11,12-LTC4	glutathione S-transferase	null	58962(Tax:10116)	Chemical	Gene	converted|nmod|START_ENTITY converted|nmod|END_ENTITY	In addition to the above nonenzymic products , 11,12-LTA4 was converted to 11,12-LTC4 by the rat liver glutathione_S-transferase , and to an isomer of 11,12-diHETE by homogenates of the guinea_pig adrenal gland and liver .
23186146	6	1,1,1,2-Ph4E	1198,1210	Ph3E	1164,1168	1,1,1,2-Ph4E	Ph3E	null	10338	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis .
1356728	0	1,1,1,2-tetrafluoroethane	98,123	cytochrome_P-450_2E1	17,37	1,1,1,2-tetrafluoroethane	cytochrome P-450 2E1	MESH:C063006	1571	Chemical	Gene	role|nmod|START_ENTITY role|nmod|oxidation oxidation|amod|END_ENTITY	Dominant role of cytochrome_P-450_2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane .
24565651	1	1,1,1,2-tetrafluoroethane	188,213	Endo	178,182	1,1,1,2-tetrafluoroethane	Endo	MESH:C063006	79694	Chemical	Gene	Ice|dep|START_ENTITY Ice|compound|END_ENTITY	INTRODUCTION : The goal of this project was to evaluate the performance of dental pulp sensibility testing with Endo Ice -LRB- 1,1,1,2-tetrafluoroethane -RRB- and an electric pulp tester -LRB- EPT -RRB- and to determine the effect of several variables on the reliability of these tests .
17909872	0	1,1,1,2-tetrafluoroethane	48,73	lipase	26,32	1,1,1,2-tetrafluoroethane	lipase	MESH:C063006	26302740	Chemical	Gene	Stability|nmod|START_ENTITY Stability|nmod|END_ENTITY	Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane -LRB- R134a -RRB- .
17909872	1	1,1,1,2-tetrafluoroethane	196,221	lipase	136,142	1,1,1,2-tetrafluoroethane	lipase	MESH:C063006	26302740	Chemical	Gene	Candida_antarctica|nmod|START_ENTITY END_ENTITY|nmod|Candida_antarctica	The stability and activity of commercial immobilized lipase from Candida_antarctica -LRB- Novozym 435 -RRB- in subcritical 1,1,1,2-tetrafluoroethane -LRB- R134a -RRB- was investigated .
26772162	0	1,1,1,3,3,3-hexafluoro-2-propanol	92,125	beta_amyloid_peptide_1-42	63,88	1,1,1,3,3,3-hexafluoro-2-propanol	beta amyloid peptide 1-42	MESH:C001337	351	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Nuclear magnetic resonance evidence for the dimer formation of beta_amyloid_peptide_1-42 in 1,1,1,3,3,3-hexafluoro-2-propanol .
27805203	3	1,1,1,3,3,3-hexafluoro-2-propanol	517,550	C-5	396,399	1,1,1,3,3,3-hexafluoro-2-propanol	C-5	MESH:C001337	727	Chemical	Gene	formed|advcl|START_ENTITY obtained|advcl|formed obtained|nsubjpass|Tris-substituted_pyrazoles Tris-substituted_pyrazoles|acl|having having|dobj|functionality functionality|nmod|position position|compound|END_ENTITY	Tris-substituted_pyrazoles , having a ketone functionality at the C-5 position , were obtained as the major product in ethanol , while di-substituted_pyrazoles were predominantly formed in 1,1,1,3,3,3-hexafluoro-2-propanol .
24847058	5	1,1,1,3,3,3-hexafluoro-2-propanol	739,772	insulin	672,679	1,1,1,3,3,3-hexafluoro-2-propanol	insulin	MESH:C001337	3630	Chemical	Gene	2,2,2-trifluoroethanol|conj|START_ENTITY concentrations|acl|2,2,2-trifluoroethanol using|dobj|concentrations END_ENTITY|acl|using	We studied the alcohol-induced amyloid_fibrillation of insulin using various concentrations of 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoro-2-propanol at pH 2.0 and 4.8 .
16004450	1	1,1,1,3,3,3-hexafluoro-2-propanol	345,378	PLCL	237,241	1,1,1,3,3,3-hexafluoro-2-propanol	PLCL	MESH:C001337	5334	Chemical	Gene	using|dobj|START_ENTITY co-electrospun|dep|using co-electrospun|nsubj|poly poly|appos|END_ENTITY	Functionally designed elastomeric nanofiber fabrics made of the equimolar copolyester , poly -LRB- L-lactide-co-epsilon-caprolactone -RRB- -LRB- PLCL -RRB- , with type I collagen or the tri-n-butylamine salt of heparin -LRB- heparin-TBA -RRB- were co-electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- as a solvent .
20401926	1	1,1,1,3,3,3-hexafluoro-2-propanol	227,260	Slc11a1	183,190	1,1,1,3,3,3-hexafluoro-2-propanol	Slc11a1	MESH:C001337	6556	Chemical	Gene	experiments|amod|START_ENTITY studied|nmod|experiments studied|nsubjpass|structure structure|nmod|corresponding corresponding|nmod|domain domain|nmod|END_ENTITY	The structure and self-assembly of the peptide corresponding to the third transmembrane domain -LRB- TMD3 -RRB- of Slc11a1 and its E139A mutant are studied in 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- aqueous solution by NMR and CD experiments .
22499248	3	1,1,1,3,3,3-hexafluoro-2-propanol	586,619	SPI	518,521	1,1,1,3,3,3-hexafluoro-2-propanol	SPI	MESH:C001337	1113	Chemical	Gene	dissolved|advcl|START_ENTITY isolate|acl|dissolved isolate|appos|END_ENTITY	We optimized and characterized fibrous scaffolds electrospun from soy protein isolate -LRB- SPI -RRB- with addition of 0.05 % poly -LRB- ethylene_oxide -RRB- -LRB- PEO -RRB- dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol , and from corn zein dissolved in glacial acetic_acid .
22839659	1	1,1,1,3,3,3-hexafluoro-2-propanol	175,208	SPI	123,126	1,1,1,3,3,3-hexafluoro-2-propanol	SPI	MESH:C001337	1113	Chemical	Gene	dissolved|nmod|START_ENTITY dissolved|nsubjpass|isolate isolate|appos|END_ENTITY	Soy protein isolate -LRB- SPI -RRB- and polyethylene_oxide -LRB- PEO -RRB- were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol -LRB- HFIP -RRB- and nonwoven nanofiber membranes were prepared from the solution by electrospinning .
8915611	4	1,1,1,3,3,3-Hexafluoro-2-propanol	410,443	PrP	532,535	1,1,1,3,3,3-Hexafluoro-2-propanol	PrP	MESH:C001337	5621	Chemical	Gene	modified|nsubj|START_ENTITY modified|dobj|ultrastructure ultrastructure|nmod|amyloids amyloids|compound|END_ENTITY	1,1,1,3,3,3-Hexafluoro-2-propanol -LRB- HFIP -RRB- , which promotes alpha-helix formation , modified the ultrastructure of rod-shaped PrP amyloids , producing flattened ribbons with a more regular substructure .
20832306	1	1,1,1,3,3,3-hexafluoro-2-propanols	161,195	malonyl-CoA_decarboxylase	227,252	1,1,1,3,3,3-hexafluoro-2-propanols	malonyl-CoA decarboxylase	null	56690(Tax:10090)	Chemical	Gene	series|nmod|START_ENTITY prepared|nsubjpass|series prepared|nmod|inhibitors inhibitors|amod|END_ENTITY	A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA_decarboxylase -LRB- MCD -RRB- inhibitors .
2356122	2	1,1,1,3,3,3-hexafluoro-2-propoxide	353,387	PCl3	393,397	1,1,1,3,3,3-hexafluoro-2-propoxide	PCl3	null	26147	Chemical	Gene	salt|nmod|START_ENTITY reaction|nmod|salt prepared|nmod|reaction prepared|nmod|END_ENTITY	Tris -LRB- 1,1,1,3,3,3-hexafluoro-2-propyl -RRB- _ phosphite , prepared by the reaction of lithium salt of 1,1,1,3,3,3-hexafluoro-2-propoxide with PCl3 , reacts with deoxyribonucleosides in the presence of a catalytic amount of triethylamine to produce in the high yield the corresponding deoxyribonucleoside_3 ' - H-phosphonate units .
28325748	7	1,1,1,3,3,3-hexafluoropropanol	1380,1410	TASK-3	1437,1443	1,1,1,3,3,3-hexafluoropropanol	TASK-3	null	51305	Chemical	Gene	carbon_tetrabromide|conj|START_ENTITY activate|nsubj|carbon_tetrabromide activate|xcomp|END_ENTITY	Similarly , carbon_tetrabromide -LRB- 296 % -LSB- 245-346 -RSB- -RRB- , carbon_tetrachloride -LRB- 180 % -LSB- 163-196 -RSB- -RRB- , and 1,1,1,3,3,3-hexafluoropropanol -LRB- 200 % -LSB- 194-206 -RSB- -RRB- activate TASK-3 , whereas the larger carbon_tetraiodide and a-chloralose inhibit .
18616310	3	1,1,1,3,3,3-hexamethyldisilazane	514,546	TMS-A	579,584	1,1,1,3,3,3-hexamethyldisilazane	TMS-A	null	7168	Chemical	Gene	HMDS|amod|START_ENTITY HMDS|appos|allyltrimethylsilane allyltrimethylsilane|appos|END_ENTITY	Among the silanizing agents used in this study were 1,1,1,3,3,3-hexamethyldisilazane -LRB- HMDS -RRB- , allyltrimethylsilane -LRB- TMS-A -RRB- , chlorotrimethylsilane -LRB- TMS-Cl -RRB- , N - -LRB- trimethylsilyl -RRB- imidazole -LRB- TMS-Im -RRB- , and N , _ N-dimethylaminotrimethylsilane -LRB- TMS-DMA -RRB- .
14518910	1	1,1,1,3,3-pentafluoropropane	302,330	CBF2	284,288	1,1,1,3,3-pentafluoropropane	CBF2	MESH:C403631	10153	Chemical	Gene	XeF2|nmod|START_ENTITY triple_bond|nmod|XeF2 triple_bond|dobj|END_ENTITY	The salt -LSB- CF3C -LSB- triple_bond -RSB- CXe -RSB- -LSB- BF4 -RSB- was prepared as neat compound by the reaction of the hitherto unknown alkynyldifluoroborane CF3C -LSB- triple_bond -RSB- CBF2 with XeF2 in 1,1,1,3,3-pentafluoropropane -LRB- PFP -RRB- at -45 degrees C in 59 % yield .
24014441	6	11-13_amino_acid	814,830	ObR	861,864	11-13 amino acid	ObR	null	3953	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A family of 11-13_amino_acid residue-long leptin receptor -LRB- ObR -RRB- agonists has been identified by analyzing the effect of peptides corresponding to the three presumed active sites of leptin on the growth of leptin-responsive cancer cells .
9756624	2	1113-amino-acid	297,312	LRP4	277,281	1113-amino-acid	LRP4	null	228357(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY	Murine LRP4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters .
27806737	7	11,13-dihydroderivative	1046,1069	C-11	1103,1107	11,13-dihydroderivative	C-11	null	51728	Chemical	Gene	START_ENTITY|dep|2H-DhL 2H-DhL|dep|mixture mixture|nmod|epimers epimers|nmod|END_ENTITY	It has been also shown that DhL and its 11,13-dihydroderivative -LRB- 2H-DhL ; a mixture of epimers at C-11 -RRB- act as blockers of the resumption of meiosis in fully grown ovarian oocytes from the amphibian Rhinella arenarum -LRB- formerly classified as Bufo arenarum -RRB- .
17705600	3	1,1,1,3-fluoroacetone	463,484	CO2	504,507	1,1,1,3-fluoroacetone	CO2	null	717	Chemical	Gene	START_ENTITY|conj|END_ENTITY	A second series of experiments using 1,1,1,3-fluoroacetone , acetonitrile , and CO2 as ligands failed to show any evidence of photofragmentation .
25030319	7	11-14_amino_acids	889,906	TF	970,972	11-14 amino acids	TF	null	14066(Tax:10090)	Chemical	Gene	length|nmod|START_ENTITY Peptides|nmod|length inhibited|nsubj|Peptides inhibited|conj|affect affect|dobj|activity activity|compound|END_ENTITY	Peptides 5 , 6 , 7 , 21 and 22 , at the length of 11-14_amino_acids , inhibited heparanase procoagulant activity but did not affect TF activity .
10984110	10	11,14-eicosadienoate	1656,1676	delta8_and_delta5_desaturases	1783,1812	11,14-eicosadienoate	delta8 and delta5 desaturases	null	84575(Tax:10116)	Chemical	Gene	fed|nsubjpass|START_ENTITY labeled|ccomp|fed arachidonate|advcl|labeled greater|advcl|arachidonate suggests|advmod|greater suggests|ccomp|metabolized metabolized|nmod|use use|nmod|END_ENTITY	However , the presence of an ion , six mass units greater than endogenous arachidonate when doubly labeled 11,14-eicosadienoate was fed , suggests that a small amount of the substrate may have been metabolized by the sequential use of delta8_and_delta5_desaturases .
19243996	10	1114G	1465,1470	RGS2	1481,1485	1114G	RGS2	null	5997	Chemical	Gene	allele|nummod|START_ENTITY allele|nmod|END_ENTITY	Neither the 393T allele of GNAS1 and 825T allele of GNB3 nor 1114G allele of RGS2 was associated with enhanced risk of severe clinical manifestation -LRB- P > 0.05 -RRB- .
14552638	7	1,1,1,5,5,5-hexafluoroacetylacetonate	639,676	L1	605,607	1,1,1,5,5,5-hexafluoroacetylacetonate	L1	null	51571	Chemical	Gene	Reactions|dep|START_ENTITY Reactions|nmod|END_ENTITY	Reactions of L1 and L2 with M -LRB- hfac -RRB- -LRB- 2 -RRB- -LRB- hfac = 1,1,1,5,5,5-hexafluoroacetylacetonate , M = Mn , Ni , Cu , Zn -RRB- produce 2:1 complexes -LRB- L -RRB- -LRB- 2 -RRB- .
9199286	2	1,116-amino-acid	308,324	mkh1	258,262	1,116-amino-acid	mkh1	MESH:C477353	854130(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY encoding|dobj|protein exon|acl|encoding contained|nmod|exon contained|nsubjpass|region region|nmod|END_ENTITY	The coding region of mkh1 is contained within a single exon encoding a 1,116-amino-acid protein .
20457951	3	11-16_nucleotides	829,846	APOE	651,655	11-16 nucleotides	APOE	MESH:D009711	348	Chemical	Gene	alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|linked linked|nmod|APOE3 APOE3|dep|encoding encoding|dobj|isoform isoform|nmod|END_ENTITY	When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset .
20457951	3	11-16_nucleotides	829,846	APOE3	611,616	11-16 nucleotides	APOE3	MESH:D009711	348	Chemical	Gene	alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|linked linked|nmod|END_ENTITY	When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset .
20457951	3	11-16_nucleotides	829,846	TOMM40	669,675	11-16 nucleotides	TOMM40	MESH:D009711	10452	Chemical	Gene	alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|dep|repeats repeats|nummod|END_ENTITY	When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset .
20457951	3	11-16_nucleotides	829,846	TOMM40	809,815	11-16 nucleotides	TOMM40	MESH:D009711	10452	Chemical	Gene	alleles|dep|START_ENTITY associated|nsubjpass|alleles associated|advcl|associated associated|nmod|age age|nmod|onset onset|conj|END_ENTITY	When linked to APOE3 -LRB- encoding the epsilon3 isoform of APOE -RRB- , the longer TOMM40 poly-T repeats -LRB- 19-39 nucleotides -RRB- at the rs10524523 -LRB- hereafter , 523 -RRB- locus are associated with earlier age at onset and the shorter TOMM40 523 alleles -LRB- 11-16_nucleotides -RRB- are associated with later age at onset .
25957974	1	11,17-dioxoandrostane	249,270	haptoglobin	304,315	11,17-dioxoandrostane	haptoglobin	null	280692(Tax:9913)	Chemical	Gene	concentrations|dep|START_ENTITY concentrations|appos|cortisol cortisol|conj|END_ENTITY	UNASSIGNED : The objective was to evaluate the association of peripartum concentrations of fecal cortisol metabolites -LRB- 11,17-dioxoandrostane ; 11,17-DOA -RRB- , plasma cortisol and haptoglobin -LRB- Hp -RRB- , as well as two markers of negative energy balance , non-esterified fatty_acid -LRB- NEFA -RRB- and postpartum_b-hydroxybutyrate -LRB- BHBA -RRB- , with milk yield and reproductive performance .
25957974	1	11,17-DOA	272,281	haptoglobin	304,315	11,17-DOA	haptoglobin	null	280692(Tax:9913)	Chemical	Gene	11,17-dioxoandrostane|dep|START_ENTITY concentrations|dep|11,17-dioxoandrostane concentrations|appos|cortisol cortisol|conj|END_ENTITY	UNASSIGNED : The objective was to evaluate the association of peripartum concentrations of fecal cortisol metabolites -LRB- 11,17-dioxoandrostane ; 11,17-DOA -RRB- , plasma cortisol and haptoglobin -LRB- Hp -RRB- , as well as two markers of negative energy balance , non-esterified fatty_acid -LRB- NEFA -RRB- and postpartum_b-hydroxybutyrate -LRB- BHBA -RRB- , with milk yield and reproductive performance .
18001136	7	11,19-oxidoprogesterone	1116,1139	FKBP52	1093,1099	11,19-oxidoprogesterone	FKBP52	MESH:C092753	2288	Chemical	Gene	recruited|nmod|START_ENTITY recruited|dobj|amounts amounts|nmod|END_ENTITY	Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 .
18001136	7	11,19-oxidoprogesterone	1170,1193	FKBP52	1093,1099	11,19-oxidoprogesterone	FKBP52	MESH:C092753	2288	Chemical	Gene	binding|amod|START_ENTITY favored|nsubj|binding favored|parataxis|recruited recruited|dobj|amounts amounts|nmod|END_ENTITY	Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 .
11909639	0	11,19-oxidoprogesterone	218,241	mineralocorticoid_receptor	48,74	11,19-oxidoprogesterone	mineralocorticoid receptor	MESH:C092753	4306	Chemical	Gene	antagonists|conj|START_ENTITY binding|nmod|antagonists evidences|nmod|binding evidences|nsubj|Modification Modification|nmod|group group|nmod|END_ENTITY	Modification of an essential amino group in the mineralocorticoid_receptor evidences a differential conformational change of the receptor protein upon binding of antagonists , natural agonists and the synthetic agonist 11,19-oxidoprogesterone .
10860927	3	11,19-oxidoprogesterone	461,484	MR	493,495	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Despite its biological potency , the relative affinity of 11,19-oxidoprogesterone for the MR is 5-fold lower than that of 21-deoxycorticosterone and 10-fold lower than aldosterone .
10860927	6	11,19-oxidoprogesterone	885,908	MR	958,960	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	START_ENTITY|conj|ability ability|acl|transform transform|dobj|END_ENTITY	We show that both the pharmacokinetic properties of 11,19-oxidoprogesterone and its ability to transform and translocate the MR into the nucleus are undistinguishable from aldosterone .
10860927	8	11,19-oxidoprogesterone	1479,1502	MR	1519,1521	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	In addition , the binding properties of both steroids are differentially affected by modification of crucial lysyl residues of the MR. Kinetic studies performed on the aldosterone-MR complex in the presence of low concentrations of oxidopregnane suggest that 11,19-oxidoprogesterone may bind to the MR in a different binding site from the aldosterone binding pocket .
11909639	6	11,19-oxidoprogesterone	1119,1142	MR	1074,1076	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	shows|nsubj|START_ENTITY shows|parataxis|END_ENTITY	Like the antagonistic ligands , and despite its potent mineralocorticoid biological effect , the sole MR specific synthetic agonist known to date , 11,19-oxidoprogesterone -LRB- 11-OP -RRB- , shows no protective effect upon treatment of the MR with pyridoxal_5 ' - phosphate or TNBS .
11909639	6	11,19-oxidoprogesterone	1119,1142	MR	1201,1203	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	shows|nsubj|START_ENTITY shows|nmod|treatment treatment|nmod|END_ENTITY	Like the antagonistic ligands , and despite its potent mineralocorticoid biological effect , the sole MR specific synthetic agonist known to date , 11,19-oxidoprogesterone -LRB- 11-OP -RRB- , shows no protective effect upon treatment of the MR with pyridoxal_5 ' - phosphate or TNBS .
18001136	5	11,19-oxidoprogesterone	859,882	MR	834,836	11,19-oxidoprogesterone	MR	MESH:C092753	4306	Chemical	Gene	used|nsubjpass|START_ENTITY used|advcl|elucidate elucidate|dobj|mechanism mechanism|nmod|action action|nmod|END_ENTITY	To elucidate the mechanism of action of MR , the synthetic ligand 11,19-oxidoprogesterone was used as a tool .
18001136	7	11,19-oxidoprogesterone	1116,1139	PP5	1277,1280	11,19-oxidoprogesterone	PP5	MESH:C092753	5536	Chemical	Gene	recruited|nmod|START_ENTITY favored|parataxis|recruited favored|dobj|recruitment recruitment|nmod|END_ENTITY	Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 .
18001136	7	11,19-oxidoprogesterone	1170,1193	PP5	1277,1280	11,19-oxidoprogesterone	PP5	MESH:C092753	5536	Chemical	Gene	binding|amod|START_ENTITY favored|nsubj|binding favored|dobj|recruitment recruitment|nmod|END_ENTITY	Importantly , aldosterone binding recruited greater amounts of FKBP52 and dynein than 11,19-oxidoprogesterone binding to MR. Interestingly , 11,19-oxidoprogesterone binding also favored the selective recruitment of the IMM-like Ser/Thr phosphatase PP5 .
8982344	4	1,11-acyl	185,194	ACAT	312,316	1,11-acyl	ACAT	null	6646	Chemical	Gene	groups|amod|START_ENTITY Replacement|nmod|groups Replacement|dep|cholesterol_acyltransferase cholesterol_acyltransferase|appos|END_ENTITY	Replacement of the 1,11-acyl groups of pyripyropenes with 1,11-cyclic _ acetals effectively improved in vitro acyl_CoA : cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitory activity .
9065427	2	111-amino_acid_polypeptide	281,307	beta3	379,384	111-amino acid polypeptide	beta3	null	1934	Chemical	Gene	START_ENTITY|acl:relcl|interacts interacts|nmod|domain domain|amod|END_ENTITY	Recently , we identified a novel 111-amino_acid_polypeptide , termed beta3-endonexin , which interacts selectively with the integrin beta3 cytoplasmic domain .
9065427	2	111-amino_acid_polypeptide	281,307	beta3-endonexin	316,331	111-amino acid polypeptide	beta3-endonexin	null	23421	Chemical	Gene	START_ENTITY|acl|termed termed|xcomp|END_ENTITY	Recently , we identified a novel 111-amino_acid_polypeptide , termed beta3-endonexin , which interacts selectively with the integrin beta3 cytoplasmic domain .
15536220	1	1_11beta-hydroxysteroid	112,135	11beta-HSD1	151,162	1 11beta-hydroxysteroid	11beta-HSD1	null	3290;26871	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Adipose tissue type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- , which generates hormonally active cortisol from inactive cortisone , has been shown to play a central role in adipocyte differentiation and abdominal_obesity-related_metabolic_complications .
15542590	3	1_11beta-hydroxysteroid	635,658	11beta-HSD1	674,685	1 11beta-hydroxysteroid	11beta-HSD1	null	100135542(Tax:10141)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	This reaction is carried out by the NADPH-dependent type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- , an enzyme attached through an integral N-terminal transmembrane helix to the lipid bilayer and located with its active site within the lumen of the endoplasmic reticulum .
16431016	1	1_11beta-hydroxysteroid	166,189	11beta-HSD1	205,216	1 11beta-hydroxysteroid	11beta-HSD1	null	3290;26871	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	The NADPH-dependent enzyme type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11beta-HSD1 -RRB- activates in a tissue-specific manner circulating pro-glucocorticoid hormones -LRB- cortisone in humans -RRB- to the 11beta-OH ligand -LRB- cortisol in humans -RRB- , which is able to bind to its cognate receptor and regulate gene transcription .
17470521	1	1_11beta-hydroxysteroid	250,273	11betaHSD2	361,371	1 11beta-hydroxysteroid	11betaHSD2	null	282434(Tax:9913)	Chemical	Gene	enzyme|amod|START_ENTITY NADP|conj|enzyme catalysed|nmod|NADP catalysed|dep|END_ENTITY	Cortisol-cortisone metabolism is catalysed by the bi-directional NADP -LRB- H -RRB- - dependent type 1_11beta-hydroxysteroid dehydrogenase -LRB- 11betaHSD1 -RRB- enzyme and the oxidative NAD -LRB- + -RRB- - dependent type 2 11betaHSD -LRB- 11betaHSD2 -RRB- .
7574456	2	1-11C-D-glucose	395,410	dl-1	503,507	1-11C-D-glucose	dl-1	null	28514	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|ml-1 ml-1|appos|END_ENTITY	We performed eight positron emission tomography studies with 1-11C-D-glucose in macaques at arterial plasma glucose concentrations of 8.43 to 1.51 mumol ml-1 -LRB- 152-27 mg dl-1 -RRB- using a model that includes a fourth rate constant to account for regional egress of all 11C-metabolites .
15585478	0	1-11C-methyl-4-piperidinyl_n-butyrate	40,77	butyrylcholinesterase	132,153	1-11C-methyl-4-piperidinyl n-butyrate	butyrylcholinesterase	MESH:C420915	590	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|agent agent|nmod|assessment assessment|nmod|activity activity|amod|END_ENTITY	Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl_n-butyrate in humans : an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET .
26703223	2	1-11E	388,393	scFv	435,439	1-11E	scFv	null	652070	Chemical	Gene	START_ENTITY|appos|variable variable|appos|END_ENTITY	We previously showed that 1-11E , a human single chain fragment variable -LRB- scFv -RRB- specific to collagen type II that has been post-translationally modified by reactive oxidants -LRB- ROS-CII -RRB- , binds exclusively to arthritic cartilage .
8390165	0	111In	1,6	alpha-MSH	33,42	111In	alpha-MSH	null	5443	Chemical	Gene	-RSB-|nsubj|START_ENTITY -RSB-|dobj|analogues analogues|nmod|END_ENTITY	-LSB- 111In -RSB- DTPA-labeled analogues of alpha-MSH for the detection of MSH receptors in vitro and in vivo .
21253675	0	111In	163,168	EGFR	198,202	111In	EGFR	null	1956	Chemical	Gene	-RSB-|amod|START_ENTITY processing|nmod|-RSB- comparison|nmod|processing receptors|dep|comparison agents|dep|receptors labeled|nsubj|agents labeled|dobj|Z Z|appos|END_ENTITY	Imaging agents for in vivo molecular profiling of disseminated prostate_cancer -- targeting EGFR receptors in prostate_cancer : comparison of cellular processing of -LSB- 111In -RSB- - labeled affibody molecule Z -LRB- EGFR :2377 -RRB- and cetuximab .
21253675	0	111In	163,168	EGFR	90,94	111In	EGFR	null	1956	Chemical	Gene	-RSB-|amod|START_ENTITY processing|nmod|-RSB- comparison|nmod|processing receptors|dep|comparison receptors|compound|END_ENTITY	Imaging agents for in vivo molecular profiling of disseminated prostate_cancer -- targeting EGFR receptors in prostate_cancer : comparison of cellular processing of -LSB- 111In -RSB- - labeled affibody molecule Z -LRB- EGFR :2377 -RRB- and cetuximab .
9153559	6	111In	1170,1175	E-selectin	1336,1346	111In	E-selectin	null	6401	Chemical	Gene	indium|appos|START_ENTITY cells|conj|indium 99mTc|dep|cells labeled|nsubj|99mTc labeled|advcl|quantify quantify|dobj|recruitment recruitment|conj|expression expression|amod|END_ENTITY	99mtechnetium -LRB- 99mTc -RRB- - labeled PMN cells and -LRB- 111 -RRB- indium -LRB- 111In -RRB- - labeled anti-E-selectin monoclonal antibody -LRB- MAb -RRB- 1.2 B6 were intravenously administered 4 hours after intraarticular injection to quantify PMN recruitment and E-selectin expression in inflamed joints .
2133278	2	111In	503,508	GM-CSF	588,594	111In	GM-CSF	null	12981(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|dep|labeled labeled|conj|used used|dobj|model model|acl|study study|dobj|influence influence|nmod|END_ENTITY	We developed a murine model to determine the biodistribution kinetics of -LSB- 111In -RSB- labeled neutrophils and used this model to study the influence of recombinant GM-CSF on neutrophil influx into inflammatory sites .
8390165	0	111In	1,6	MSH	64,67	111In	MSH	null	5443	Chemical	Gene	-RSB-|nsubj|START_ENTITY -RSB-|nmod|detection detection|nmod|receptors receptors|compound|END_ENTITY	-LSB- 111In -RSB- DTPA-labeled analogues of alpha-MSH for the detection of MSH receptors in vitro and in vivo .
15305020	2	111In	415,420	transferrin	463,474	111In	transferrin	null	24825(Tax:10116)	Chemical	Gene	entering|nmod|START_ENTITY entering|nmod|affinity affinity|acl|END_ENTITY	In the present study , we investigated whether the entering of indium-111 -LRB- 111In -RRB- and iron-59 _ -LRB- 59Fe -RRB- with high affinity to transferrin differed from the entering of 67Ga by the hepatocytes after partial hepatectomy .
1751138	2	111In	270,275	VWF	157,160	111In	VWF	null	7450	Chemical	Gene	platelets|amod|START_ENTITY donors|nmod:poss|platelets exposing|nmod|donors examined|advcl|exposing examined|nsubjpass|role role|nmod|factor factor|appos|END_ENTITY	The role of von_Willebrand 's _ factor -LRB- VWF -RRB- was examined in platelet deposition on polyethylene by exposing 3/16 inch diameter discs of polyethylene to 111In labeled platelets re-suspended in citrated blood from normal and severe von_Willebrand 's disease donors .
1330982	4	111In-2G3	794,803	transferrin	764,775	111In-2G3	transferrin	null	7018	Chemical	Gene	stability|nmod|START_ENTITY differ|nsubj|stability differ|nmod|basis basis|nmod|measurement measurement|nmod|transchelation transchelation|nmod|END_ENTITY	On the basis of measurement of transchelation to transferrin , the stability of 111In-2G3 prepared using DTPA_anhydride or benzyl_DTPA did not differ during incubation in human plasma for 6 days at 37 degrees C .
24665085	0	111In-ABY-025	90,103	HER2	36,40	111In-ABY-025	HER2	null	2064	Chemical	Gene	molecule|amod|START_ENTITY using|dobj|molecule metastases|xcomp|using metastases|nsubj|imaging imaging|nmod|expression expression|nummod|END_ENTITY	First-in-human molecular imaging of HER2 expression in breast_cancer metastases using the 111In-ABY-025 affibody molecule .
1692949	1	111In-BLMC	129,139	SCLC	267,271	111In-BLMC	SCLC	null	7864	Chemical	Gene	complex|dep|START_ENTITY agent|nsubj|complex agent|acl:relcl|produces produces|conj|kills kills|dobj|cells cells|appos|END_ENTITY	Indium-111-bleomycin complex -LRB- 111In-BLMC -RRB- is a radiopharmaceutical agent that produces tumor regression in mouse glioma in vivo and kills human small_cell_lung_cancer -LRB- SCLC -RRB- cells in vitro .
6498219	6	111In-Ca-DTPA	2073,2086	IgG1	2123,2127	111In-Ca-DTPA	IgG1	null	16017(Tax:10090)	Chemical	Gene	carboxyfluorescein|conj|START_ENTITY devoid|amod|carboxyfluorescein devoid|nmod|END_ENTITY	AKR mice were injected intravenously with 99mTc-labelled AKR-A cells and 2.5 min later with anti-Thy1 125I-IgG1-bearing liposomes containing quenched carboxyfluorescein and 111In-Ca-DTPA or with similar liposomes devoid of IgG1 .
18034550	0	111In-capromab_pendetide	0,24	prostate_specific_membrane_antigen	43,77	111In-capromab pendetide	prostate specific membrane antigen	null	2346	Chemical	Gene	START_ENTITY|dep|evolution evolution|nmod|END_ENTITY	111In-capromab_pendetide : the evolution of prostate_specific_membrane_antigen and the nuclear imaging of its 111In-labelled murine antibody in the evaluation of prostate_cancer .
22284727	4	111InCl3	639,647	anti-carbonic_anhydrase_IX	835,861	111InCl3	anti-carbonic anhydrase IX	null	768	Chemical	Gene	amounts|nmod|START_ENTITY added|nsubjpass|amounts added|nmod|g g|nmod|-LSB- -LSB-|acl:relcl|tetraacetic_acid tetraacetic_acid|dobj|-RSB- -RSB-|dep|compounds compounds|dep|antibody antibody|compound|octreotide octreotide|conj|END_ENTITY	METHODS : Escalating amounts of 111InCl3 were added to 1 g of the diethylene_triamine_pentaacetic_acid -LSB- DTPA -RSB- - and 1,4,7,10-tetraazacyclododecane-1 ,4,7,10 - tetraacetic_acid -LSB- DOTA -RSB- - conjugated compounds -LRB- exendin-3 , octreotide and anti-carbonic_anhydrase_IX -LSB- CAIX -RSB- antibody -RRB- .
22284727	4	111InCl3	639,647	CAIX	863,867	111InCl3	CAIX	null	768	Chemical	Gene	amounts|nmod|START_ENTITY added|nsubjpass|amounts added|nmod|g g|nmod|-LSB- -LSB-|acl:relcl|tetraacetic_acid tetraacetic_acid|dobj|-RSB- -RSB-|dep|compounds compounds|dep|antibody antibody|compound|END_ENTITY	METHODS : Escalating amounts of 111InCl3 were added to 1 g of the diethylene_triamine_pentaacetic_acid -LSB- DTPA -RSB- - and 1,4,7,10-tetraazacyclododecane-1 ,4,7,10 - tetraacetic_acid -LSB- DOTA -RSB- - conjugated compounds -LRB- exendin-3 , octreotide and anti-carbonic_anhydrase_IX -LSB- CAIX -RSB- antibody -RRB- .
16710024	4	111In-diethylenetriamine_penta-acetic_acid_anhydride	738,790	epidermal_growth_factor_receptor_2	577,611	111In-diethylenetriamine penta-acetic acid anhydride	epidermal growth factor receptor 2	null	2064	Chemical	Gene	MBq|amod|START_ENTITY injection|nmod|MBq underwent|nmod|injection underwent|nsubj|Patients Patients|nmod|END_ENTITY	PATIENTS AND METHODS : Patients with human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- - positive metastatic breast_cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In-diethylenetriamine_penta-acetic_acid_anhydride -LRB- DTPA -RRB- - trastuzumab , after loading-dose trastuzumab , and after once-a-week trastuzumab doses for 11 weeks , and concomitant paclitaxel once every 3 weeks .
16710024	4	111In-diethylenetriamine_penta-acetic_acid_anhydride	738,790	HER2	613,617	111In-diethylenetriamine penta-acetic acid anhydride	HER2	null	2064	Chemical	Gene	MBq|amod|START_ENTITY injection|nmod|MBq underwent|nmod|injection underwent|nsubj|Patients Patients|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|appos|END_ENTITY	PATIENTS AND METHODS : Patients with human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- - positive metastatic breast_cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In-diethylenetriamine_penta-acetic_acid_anhydride -LRB- DTPA -RRB- - trastuzumab , after loading-dose trastuzumab , and after once-a-week trastuzumab doses for 11 weeks , and concomitant paclitaxel once every 3 weeks .
3657182	1	111-indium	363,373	anti-carcinoembryonic_antigen	285,314	111-indium	anti-carcinoembryonic antigen	MESH:C020758	1084	Chemical	Gene	mCi|nmod|START_ENTITY labeled|nmod|mCi micrograms|acl|labeled micrograms|nmod|antibody antibody|amod|END_ENTITY	Patients with primary and/or metastatic colorectal_cancer who had been scheduled for operative intervention were injected intravenously with 200 micrograms of a high-affinity anti-carcinoembryonic_antigen -LRB- CEA -RRB- monoclonal antibody labeled with 2 mCi of 111-indium -LRB- Indacea -RRB- .
3657182	1	111-indium	363,373	CEA	316,319	111-indium	CEA	MESH:C020758	1084	Chemical	Gene	mCi|nmod|START_ENTITY labeled|nmod|mCi micrograms|acl|labeled micrograms|nmod|antibody antibody|appos|END_ENTITY	Patients with primary and/or metastatic colorectal_cancer who had been scheduled for operative intervention were injected intravenously with 200 micrograms of a high-affinity anti-carcinoembryonic_antigen -LRB- CEA -RRB- monoclonal antibody labeled with 2 mCi of 111-indium -LRB- Indacea -RRB- .
12094949	1	111-indium	232,242	cytokeratin_19	286,300	111-indium	cytokeratin 19	MESH:C020758	16669(Tax:10090)	Chemical	Gene	labeling|dobj|START_ENTITY labeling|nmod|antibody antibody|nmod|END_ENTITY	PURPOSE : To establish a radioimmunodetection -LRB- RAID -RRB- system for localization of cervical_cancer by labeling 111-indium -LRB- -LRB- 111 -RRB- In -RRB- to a monoclonal antibody against cytokeratin_19 -LRB- MAb Cx-99 -RRB- , and detecting it with a hand-held gamma detector in an animal model .
3349123	2	111Indium	560,569	AT_III	460,466	111Indium	AT III	null	462	Chemical	Gene	labelled|nmod|START_ENTITY antibody|acl|labelled END_ENTITY|conj|antibody	This paper describes an isotopic method to estimate this density and to visualize the distribution of the affinity sites concerned , both directly with AT_III labelled with 125Iodine and indirectly with an anti AT_III monoclonal antibody labelled with 111Indium .
3349123	2	111Indium	560,569	AT_III	519,525	111Indium	AT III	null	462	Chemical	Gene	labelled|nmod|START_ENTITY antibody|acl|labelled antibody|compound|END_ENTITY	This paper describes an isotopic method to estimate this density and to visualize the distribution of the affinity sites concerned , both directly with AT_III labelled with 125Iodine and indirectly with an anti AT_III monoclonal antibody labelled with 111Indium .
10615242	1	111Indium	134,143	GA17	206,210	111Indium	GA17	null	10480	Chemical	Gene	111In|amod|START_ENTITY 111In|acl|labelled labelled|xcomp|internalising internalising|dobj|END_ENTITY	The potential of 111Indium -LRB- 111In -RRB- - labelled internalising anti-integrin_alpha_3 antibody GA17 in the radioimmunotherapy of human glioblastoma xenografts in nude_mice was investigated .
3682767	4	111Indium	589,598	lactate_dehydrogenase	556,577	111Indium	lactate dehydrogenase	null	101409728	Chemical	Gene	51Chromium|conj|START_ENTITY 51Chromium|conj|END_ENTITY	We compared the loss of 51Chromium -LRB- 51Cr -RRB- , the cytoplasmic enzyme lactate_dehydrogenase -LRB- LDH -RRB- , and 111Indium -LRB- 111In -RRB- from endothelial cells upon exposure to several injurious agents .
3682767	4	111Indium	589,598	LDH	579,582	111Indium	LDH	null	101409728	Chemical	Gene	51Chromium|conj|START_ENTITY 51Chromium|conj|lactate_dehydrogenase lactate_dehydrogenase|appos|END_ENTITY	We compared the loss of 51Chromium -LRB- 51Cr -RRB- , the cytoplasmic enzyme lactate_dehydrogenase -LRB- LDH -RRB- , and 111Indium -LRB- 111In -RRB- from endothelial cells upon exposure to several injurious agents .
12472080	9	111Indium	1575,1584	somatostatin	1623,1635	111Indium	somatostatin	MESH:C020758	6750	Chemical	Gene	based|nmod|START_ENTITY based|advcl|analogues analogues|compound|END_ENTITY	Radioligand therapy based on 111Indium , 90Yttrium and 177Lutetium coupled to somatostatin analogues via bifunctional chelators is currently under investigation with promising data concerning long-lasting control of symptoms and tumour_growth from Phase I trials .
4077977	6	111Indium	911,920	thrombin	877,885	111Indium	thrombin	null	2147	Chemical	Gene	adding|dobj|START_ENTITY washed|advcl|adding treated|conj|washed treated|nmod|END_ENTITY	Furthermore , enhanced neutrophil adherence occurred when endothelial monolayers were treated with thrombin and washed before adding 111Indium -LRB- 111In -RRB- - labeled PMNs .
10799151	14	111Indium_capromab_pendetide	2134,2162	PSA	2232,2235	111Indium capromab pendetide	PSA	MESH:C063430	354	Chemical	Gene	scan|amod|START_ENTITY scan|acl:relcl|approved approved|nmod|recurrence recurrence|compound|END_ENTITY	111Indium_capromab_pendetide radionuclide scan , which has been approved for radical prostatectomy PSA only recurrence , may be helpful to determine cases best suited for salvage radiotherapy versus systemic hormonal therapy , although more study is needed .
1944906	0	111indium-DTPA	27,41	CSF	42,45	111indium-DTPA	CSF	MESH:C103803	1437	Chemical	Gene	studies|amod|START_ENTITY studies|compound|END_ENTITY	Leptomeningeal_metastases : 111indium-DTPA CSF flow studies .
1944906	1	111indium-DTPA	176,190	CSF	196,199	111indium-DTPA	CSF	MESH:C103803	1437	Chemical	Gene	studies|amod|START_ENTITY studies|compound|END_ENTITY	Thirty consecutive patients with cytologically documented leptomeningeal_metastases -LRB- LM -RRB- underwent intraventricular 111indium-DTPA -LRB- In -RRB- CSF flow studies -LRB- FS -RRB- .
6237710	2	111indium-DTPA	553,567	M8	413,415	111indium-DTPA	M8	MESH:C103803	149830	Chemical	Gene	conjugate|amod|START_ENTITY using|dobj|conjugate recorded|xcomp|using found|conj|recorded found|nmod|degree degree|nmod|localization localization|nmod|END_ENTITY	No significant difference was found in the degree of localization of radio-iodinated M8 in subcutaneous , renal or intracranial xenografts , but a highly significant improvement in HX99 localization by M8 was recorded using an 111indium-DTPA conjugate of the antibody -LRB- 111In-DTPA-M8 -RRB- , related to its rapid tumour uptake and blood pool clearance .
6388012	1	111Indium_oxine	80,95	beta_TG	188,195	111Indium oxine	beta TG	null	5473	Chemical	Gene	studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|END_ENTITY	Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg .
6388012	1	111Indium_oxine	80,95	beta-thromboglobulin	166,186	111Indium oxine	beta-thromboglobulin	null	5473	Chemical	Gene	studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|beta_TG beta_TG|amod|END_ENTITY	Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg .
25330503	7	111Indium_oxine	957,972	hTEC	919,923	111Indium oxine	hTEC	null	7006	Chemical	Gene	using|dobj|START_ENTITY studied|xcomp|using studied|nsubjpass|biodistribution biodistribution|nmod|END_ENTITY	The biodistribution and fate of hTEC were studied using radiolabelled 111Indium_oxine and fluorescent in situ hybridisation .
6388012	1	111Indium_oxine	80,95	PF4	220,223	111Indium oxine	PF4	null	5196	Chemical	Gene	studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|platelet_factor_4 platelet_factor_4|appos|END_ENTITY	Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg .
6388012	1	111Indium_oxine	80,95	platelet_factor_4	201,218	111Indium oxine	platelet factor 4	null	5196	Chemical	Gene	studies|nmod|START_ENTITY labelled|nsubj|studies labelled|dobj|life-span life-span|conj|END_ENTITY	Baseline studies of 111Indium_oxine labelled platelet life-span , platelet alpha-granule release products , beta-thromboglobulin -LRB- beta_TG -RRB- and platelet_factor_4 -LRB- PF4 -RRB- , and factor VIII related activities were performed on 9 asymptomatic patients with sickle_cell_disease , who were subsequently randomised in a prospective double-blind trial of ticlopidine -LRB- 250 mg .
8504205	3	111Indium-oxine	549,564	interleukin-2	517,530	111Indium-oxine	interleukin-2	MESH:C032950	3558	Chemical	Gene	labeled|advcl|START_ENTITY labeled|nsubjpass|lymphocytes lymphocytes|acl|isolated isolated|nmod|malignant_metastatic_breast_cancer malignant_metastatic_breast_cancer|acl|cultured cultured|advcl|vitro vitro|nmod|low-dose low-dose|nmod|END_ENTITY	Tumor-infiltrating lymphocytes isolated from five patients with malignant_metastatic_breast_cancer or melanoma cultured and expanded in vitro with low-dose of recombinant interleukin-2 were labeled with 111Indium-oxine and infused to the patients .
18481386	9	111Indium-oxine	1252,1267	mDC	1322,1325	111Indium-oxine	mDC	null	20299(Tax:10090)	Chemical	Gene	gave|nsubj|START_ENTITY gave|dobj|tracking tracking|nmod|nmDc nmDc|conj|END_ENTITY	111Indium-oxine , however , gave reproducible tracking of both nmDc and mDC -LRB- n = 6 -RRB- to regional lymph node after either SC or ID administration , with mDC revealing superior migration to regional lymph node .
18481386	9	111Indium-oxine	1252,1267	mDC	1398,1401	111Indium-oxine	mDC	null	20299(Tax:10090)	Chemical	Gene	gave|nsubj|START_ENTITY gave|nmod|END_ENTITY	111Indium-oxine , however , gave reproducible tracking of both nmDc and mDC -LRB- n = 6 -RRB- to regional lymph node after either SC or ID administration , with mDC revealing superior migration to regional lymph node .
20542702	2	111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic_acid-cholecystokinin_octapeptide	664,753	CCK2R	515,520	111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic acid-cholecystokinin octapeptide	CCK2R	null	887	Chemical	Gene	visualization|amod|START_ENTITY END_ENTITY|conj|visualization	To our knowledge this is the first CCK4-based radioligand that presents a high affinity for the CCK2R , a high and specific tumor uptake , a low_renal_accumulation and a very good visualization of tumors in vivo compared with an internal control , 111Indium-trans-cyclohexyldiethylenetriaminepenta-acetic_acid-cholecystokinin_octapeptide -LRB- 111In-CHX-A '' - DTPA-CCK8 -RRB- .
25007399	8	111In-DOTA	1225,1235	sst2	1271,1275	111In-DOTA	sst2	null	20606(Tax:10090)	Chemical	Gene	LTT-SS28|amod|START_ENTITY mimic|dobj|LTT-SS28 mimic|dep|sst3 sst3|nmod|END_ENTITY	In conclusion , the somatostatin mimic -LSB- 111In-DOTA -RSB- LTT-SS28 specifically localizes in sst2 - , sst3 - , and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging .
25007399	8	111In-DOTA	1225,1235	sst3	1278,1282	111In-DOTA	sst3	null	20607(Tax:10090)	Chemical	Gene	LTT-SS28|amod|START_ENTITY mimic|dobj|LTT-SS28 mimic|dep|END_ENTITY	In conclusion , the somatostatin mimic -LSB- 111In-DOTA -RSB- LTT-SS28 specifically localizes in sst2 - , sst3 - , and sst5-expressing xenografts in mice showing promise for multi-sst1-sst5 targeted tumor imaging .
19820010	3	111In-DOTA-exendin-4	481,501	GLP-1R	466,472	111In-DOTA-exendin-4	GLP-1R	null	2740	Chemical	Gene	using|dep|START_ENTITY using|nsubj|agonist agonist|compound|END_ENTITY	OBJECTIVE : The objective of the study was to test the 111In-labeled GLP-1R agonist 111In-DOTA-exendin-4 in localizing insulinomas using single photon emission computed tomography in combination with computed tomography images .
16021448	6	111In-DTPA-octreotide	1087,1108	somatostatin_receptor_subtype_2	1279,1310	111In-DTPA-octreotide	somatostatin receptor subtype 2	MESH:C071632	54305(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY effects|nmod|doses investigated|nsubjpass|effects investigated|advcl|bearing bearing|dobj|pancreatic_CA20948_tumours pancreatic_CA20948_tumours|acl|expressing expressing|dobj|END_ENTITY	METHODS : The radiotherapeutic effects of different doses of 111In-DTPA-octreotide in vivo were investigated in Lewis rats bearing small -LRB- < or = 1 cm2 -RRB- or large -LRB- > or = 8 cm2 -RRB- somatostatin receptor-positive rat pancreatic_CA20948_tumours expressing the somatostatin_receptor_subtype_2 -LRB- sst2 -RRB- .
16021448	6	111In-DTPA-octreotide	1087,1108	sst2	1312,1316	111In-DTPA-octreotide	sst2	MESH:C071632	54305(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY effects|nmod|doses investigated|nsubjpass|effects investigated|advcl|bearing bearing|dobj|pancreatic_CA20948_tumours pancreatic_CA20948_tumours|appos|END_ENTITY	METHODS : The radiotherapeutic effects of different doses of 111In-DTPA-octreotide in vivo were investigated in Lewis rats bearing small -LRB- < or = 1 cm2 -RRB- or large -LRB- > or = 8 cm2 -RRB- somatostatin receptor-positive rat pancreatic_CA20948_tumours expressing the somatostatin_receptor_subtype_2 -LRB- sst2 -RRB- .
16150802	7	111In-labeled_alphavbeta3	1000,1025	RP748	990,995	111In-labeled alphavbeta3	RP748	null	883913(Tax:272947)	Chemical	Gene	radiotracer|amod|START_ENTITY injected|nsubjpass|radiotracer injected|advmod|END_ENTITY	RP748 , an 111In-labeled_alphavbeta3 -LRB- active conformation -RRB- - targeted radiotracer was injected into groups of 5 recipients at 0 , 2 , and 4 wk after PBMC reconstitution .
6403626	6	111In-labeled_C3	1055,1071	fibrinogen	965,975	111In-labeled C3	fibrinogen	null	2244	Chemical	Gene	precipitates|amod|START_ENTITY experiments|nmod|precipitates over-estimated|nmod|experiments over-estimated|nsubjpass|111In 111In|acl|associated associated|nmod|END_ENTITY	111In associated with fibrinogen , IgM , and haptoglobin was over-estimated in some experiments due to binding of 111In-labeled_C3 to the antigen-antibody precipitates .
6403626	6	111In-labeled_C3	1055,1071	haptoglobin	986,997	111In-labeled C3	haptoglobin	null	3240	Chemical	Gene	precipitates|amod|START_ENTITY experiments|nmod|precipitates over-estimated|nmod|experiments over-estimated|nsubjpass|111In 111In|acl|associated associated|nmod|fibrinogen fibrinogen|conj|END_ENTITY	111In associated with fibrinogen , IgM , and haptoglobin was over-estimated in some experiments due to binding of 111In-labeled_C3 to the antigen-antibody precipitates .
24718894	2	111In-labeled_capromab_pendetide	312,344	prostate-specific_membrane_antigen	265,299	111In-labeled capromab pendetide	prostate-specific membrane antigen	null	2346	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	Radionuclide targeting of prostate-specific_membrane_antigen -LRB- PSMA -RRB- with 111In-labeled_capromab_pendetide -LRB- ProstaScint -RRB- is a clinical option for prostate_cancer staging .
24718894	2	111In-labeled_capromab_pendetide	312,344	PSMA	301,305	111In-labeled capromab pendetide	PSMA	null	2346	Chemical	Gene	prostate-specific_membrane_antigen|nmod|START_ENTITY prostate-specific_membrane_antigen|appos|END_ENTITY	Radionuclide targeting of prostate-specific_membrane_antigen -LRB- PSMA -RRB- with 111In-labeled_capromab_pendetide -LRB- ProstaScint -RRB- is a clinical option for prostate_cancer staging .
8864137	14	111In-labeled_DC	1276,1292	IFN-gamma	1238,1247	111In-labeled DC	IFN-gamma	null	15978(Tax:10090)	Chemical	Gene	using|xcomp|START_ENTITY conducted|xcomp|using conducted|nmod|END_ENTITY	Biodistribution and imaging studies were conducted on IFN-gamma - and PBS-treated mice using 111In-labeled_DC .
6895481	4	111In-labeled_diethylenetriaminepentaacetic_acid	706,754	L-asparaginase	618,632	111In-labeled diethylenetriaminepentaacetic acid	L-asparaginase	null	80150	Chemical	Gene	-LSB-|advcl|START_ENTITY did|ccomp|-LSB- demonstrated|advcl|did demonstrated|nsubj|activity activity|nmod|END_ENTITY	Following intrathecal injection , the enzyme activity of Escherichia_coli L-asparaginase in the CSF demonstrated a more rapid terminal half-life than did that of 111In-labeled_diethylenetriaminepentaacetic_acid , a marker of CSF bulk flow -LSB- 4 + / - 0.7 -LRB- S.D. -RRB- hr versus 5.8 + / - 0.2 hr -RSB- .
10716315	0	111In-labeled_EGF	0,17	EGFR	88,92	111In-labeled EGF	EGFR	null	1956	Chemical	Gene	radiotoxic|nsubj|START_ENTITY radiotoxic|xcomp|overexpressing overexpressing|dobj|END_ENTITY	111In-labeled_EGF is selectively radiotoxic to human breast_cancer cells overexpressing EGFR .
17015904	2	111In-labeled_phosphorothioate	283,313	N-myc	379,384	111In-labeled phosphorothioate	N-myc	null	4613	Chemical	Gene	oligonucleotides|amod|START_ENTITY emitted|nmod|oligonucleotides emitted|nmod|cells cells|acl:relcl|overexpressed overexpressed|nsubjpass|END_ENTITY	We investigated the therapeutic effect of Auger electrons emitted by 111In-labeled_phosphorothioate antisense oligonucleotides on human neuroblastoma cells in which N-myc was overexpressed .
21993546	2	111In-minigastrin	418,435	GOT2	343,347	111In-minigastrin	GOT2	null	14719(Tax:10090)	Chemical	Gene	177Lu-octreotate|conj|START_ENTITY biodistribution|nmod|177Lu-octreotate analyzing|dobj|biodistribution evaluate|advcl|analyzing evaluate|dobj|model model|compound|END_ENTITY	The aim of this study was to evaluate the medullary_thyroid_carcinoma GOT2 animal model by analyzing the biodistribution of 177Lu-octreotate and 111In-minigastrin -LRB- MG0 -RRB- .
1306326	4	111In-Nd2	581,590	IgG1	715,719	111In-Nd2	IgG1	null	105243590	Chemical	Gene	xenograft|amod|START_ENTITY injection|nmod|xenograft days|dep|injection was|nmod|days was|nsubj|accumulation accumulation|nmod|tumor tumor|acl|END_ENTITY	Four days after injection of 111In-Nd2 into athymic nude_mice bearing SW1990 xenograft there was a higher accumulation in the tumor compared to 111In-normal mouse IgG1 .
11159212	3	111In-octreotide	669,685	VMAT1	564,569	111In-octreotide	VMAT1	MESH:C094279	6570	Chemical	Gene	using|xcomp|START_ENTITY visualized|xcomp|using visualized|nmod|expression expression|nmod|receptors receptors|conj|END_ENTITY	Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine .
11159212	3	111In-octreotide	669,685	VMAT2	574,579	111In-octreotide	VMAT2	MESH:C094279	6571	Chemical	Gene	using|xcomp|START_ENTITY visualized|xcomp|using visualized|nmod|expression expression|nmod|receptors receptors|conj|VMAT1 VMAT1|conj|END_ENTITY	Because of the expression of somatostatin receptors and VMAT1 and VMAT2 the grafted tumors could be visualized scintigraphically using the somatostatin analogue 111In-octreotide and the catecholamine analogue 123I-metaiodobenzylguanidine .
2964877	3	111In-oxine	446,457	CIG	552,555	111In-oxine	CIG	MESH:C032950	2335	Chemical	Gene	labelled|advcl|START_ENTITY labelled|nmod|globulin globulin|appos|END_ENTITY	To examine cell adhesion , endothelial cells were labelled with 111In-oxine and inoculated onto prosthetic wells previously prepared with either cold insoluble globulin -LRB- CIG -RRB- , 1 % gelatin , alginate or left untreated as a control .
7659388	1	111In-oxine	192,203	interleukin-6	356,369	111In-oxine	interleukin-6	MESH:C032950	3569	Chemical	Gene	imaging|amod|START_ENTITY doses|nmod|imaging macrophages|nmod|doses labelling|nmod|macrophages damage|nsubj|labelling damage|dobj|viability viability|conj|competence competence|nmod|cells cells|dep|secretion secretion|amod|factor-alpha factor-alpha|conj|END_ENTITY	The labelling of ex-vivo activated macrophages with doses of 111In-oxine sufficient for gamma camera imaging does not damage cell viability or the functional competence of cells -LRB- secretion of tumour necrosis factor-alpha and interleukin-6 -RRB- .
1658591	10	111In-oxine	889,900	LAK	910,913	111In-oxine	LAK	MESH:C032950	71481(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	In experimental study , accumulation of 111In-oxine labelled LAK cells in mouse 3LL lung_cancer was augmented in splenectomized ones .
15285807	5	111In-Oxine	699,710	DC	662,664	111In-Oxine	DC	MESH:C032950	20299(Tax:10090)	Chemical	Gene	99mTc-HMPAO|conj|START_ENTITY labelled|advcl|99mTc-HMPAO labelled|nsubjpass|END_ENTITY	METHODS : DC were labelled with 99mTc-HMPAO or 111In-Oxine , and the presence of labelled DC in regional lymph nodes was evaluated at pre-set times up to a maximum of 72 h after inoculation .
15285807	5	111In-Oxine	699,710	DC	741,743	111In-Oxine	DC	MESH:C032950	20299(Tax:10090)	Chemical	Gene	99mTc-HMPAO|conj|START_ENTITY labelled|advcl|99mTc-HMPAO labelled|conj|evaluated evaluated|nsubjpass|presence presence|nmod|END_ENTITY	METHODS : DC were labelled with 99mTc-HMPAO or 111In-Oxine , and the presence of labelled DC in regional lymph nodes was evaluated at pre-set times up to a maximum of 72 h after inoculation .
9002771	1	111In-pentetreotide	286,305	CEA	260,263	111In-pentetreotide	CEA	MESH:C081788	5670	Chemical	Gene	scintigraphy|amod|START_ENTITY using|dobj|scintigraphy detected|xcomp|using detected|nsubjpass|recurrences recurrences|nmod|medullary_thyroid_carcinoma medullary_thyroid_carcinoma|nmod|patients patients|nmod|levels levels|nmod|END_ENTITY	Local and lymphnodal recurrences of medullary_thyroid_carcinoma -LRB- MTC -RRB- in thyroidectomy patients with elevated plasma levels of calcitonin and/or CEA can be detected using 111In-pentetreotide -LRB- Octreoscan : OCT -RRB- scintigraphy , although the sensitivity of this technique in localizing an intrathyroid recurrence of tumor is affected by the low target/non-target uptake ratio .
8964877	17	111In-pentetreotide	1904,1923	IGF-I	1996,2001	111In-pentetreotide	IGF-I	MESH:C081788	3479	Chemical	Gene	scintigraphy|amod|START_ENTITY subjected|nmod|scintigraphy patients|acl|subjected had|nmod|patients had|parataxis|obtained obtained|nsubjpass|normalization normalization|nmod|GH GH|conj|END_ENTITY	Of the 26 patients subjected to 111In-pentetreotide scintigraphy , 13 had significant tracer uptake : normalization of GH and IGF-I was obtained in 8 patients .
22785503	2	111In-pentetreotide	284,303	OCT	317,320	111In-pentetreotide	OCT	MESH:C081788	5362	Chemical	Gene	START_ENTITY|appos|OctreoScan OctreoScan|dep|END_ENTITY	A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients .
22785503	2	111In-pentetreotide	284,303	OCT	367,370	111In-pentetreotide	OCT	MESH:C081788	5362	Chemical	Gene	PET/CT|conj|START_ENTITY indicating|nsubj|PET/CT indicating|nmod|END_ENTITY	A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients .
22785503	2	111In-pentetreotide	284,303	OCT	417,420	111In-pentetreotide	OCT	MESH:C081788	5362	Chemical	Gene	PET/CT|conj|START_ENTITY indicating|nsubj|PET/CT presented|advcl|indicating presented|conj|compared compared|xcomp|END_ENTITY	A few reports have presented imaging results with FDG PET/CT or 111In-pentetreotide -LRB- OctreoScan , OCT -RRB- indicating a higher sensitivity for FDG than OCT , but no reports have directly compared FDG to OCT in the same patients .
9002771	1	111In-pentetreotide	286,305	OCT	319,322	111In-pentetreotide	OCT	MESH:C081788	5362	Chemical	Gene	scintigraphy|amod|START_ENTITY scintigraphy|appos|Octreoscan Octreoscan|dep|END_ENTITY	Local and lymphnodal recurrences of medullary_thyroid_carcinoma -LRB- MTC -RRB- in thyroidectomy patients with elevated plasma levels of calcitonin and/or CEA can be detected using 111In-pentetreotide -LRB- Octreoscan : OCT -RRB- scintigraphy , although the sensitivity of this technique in localizing an intrathyroid recurrence of tumor is affected by the low target/non-target uptake ratio .
8895910	7	111In-pentetreotide	931,950	somatostatin	808,820	111In-pentetreotide	somatostatin	MESH:C081788	6750	Chemical	Gene	scintigraphy|amod|START_ENTITY outcome|nmod|scintigraphy affect|dobj|outcome affect|nsubj|detection detection|nmod|END_ENTITY	The detection of somatostatin within the tumour -LRB- 2 patients -RRB- , or negative octreotide challenges -LRB- 2 patients -RRB- , did not affect the outcome of 111In-pentetreotide scintigraphy .
9516858	7	111In-pentetreotide	1120,1139	somatostatin	1184,1196	111In-pentetreotide	somatostatin	MESH:C081788	6750	Chemical	Gene	using|xcomp|START_ENTITY using|nsubj|tumours tumours|acl|expressing expressing|dobj|receptors receptors|compound|END_ENTITY	Scintigraphy using 111In-pentetreotide identified tumours expressing high-affinity somatostatin receptors in vivo .
9042206	4	111In-ZCE025	649,661	CEA	697,700	111In-ZCE025	CEA	null	1084	Chemical	Gene	START_ENTITY|appos|END_ENTITY	For mice given 111In-ZCE025 , an anti-carcinoembryonic antigen -LRB- CEA -RRB- MAb , the biodistribution of activity was determined 7 days later .
10536187	10	111In-Zevalin	1672,1685	CD20	1641,1645	111In-Zevalin	CD20	null	12482(Tax:10090)	Chemical	Gene	accumulated|nsubj|START_ENTITY demonstrated|ccomp|accumulated demonstrated|nsubj|Studies Studies|nmod|mice mice|acl|bearing bearing|dobj|tumors tumors|nummod|END_ENTITY	Studies in athymic mice bearing CD20 + tumors demonstrated that 111In-Zevalin accumulated in the tumors preferentially compared with normal organs .
13677323	8	1,1,1-kestopentaose	996,1015	DP5	934,937	1,1,1-kestopentaose	DP5	MESH:C082830	8739	Chemical	Gene	kestopentaose|conj|START_ENTITY ,1|amod|kestopentaose ,1|nsubj|fructans fructans|compound|END_ENTITY	The three major DP5 fructans are 1_6 ,1 - kestopentaose , 1,1 _ 6-kestopentaose and 1,1,1-kestopentaose .
20610725	4	111-nucleotide	579,593	7SL	614,617	111-nucleotide	7SL	MESH:D009711	6029	Chemical	Gene	portion|amod|START_ENTITY portion|nmod|END_ENTITY	Nuclease mapping showed that 7SLrem is a 111-nucleotide internal portion of 7SL , with 5 ' and 3 ' ends corresponding to unpaired loops in the 7SL two-dimensional structure .
20610725	4	111-nucleotide	579,593	7SL	678,681	111-nucleotide	7SL	MESH:D009711	6029	Chemical	Gene	portion|amod|START_ENTITY portion|advcl|ends ends|nmod|loops loops|nmod|structure structure|nummod|END_ENTITY	Nuclease mapping showed that 7SLrem is a 111-nucleotide internal portion of 7SL , with 5 ' and 3 ' ends corresponding to unpaired loops in the 7SL two-dimensional structure .
15811676	0	1,1,1-TCA	106,115	CCl4	97,101	1,1,1-TCA	CCl4	null	6351	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Laboratory batch experiments of the combined effects of ultrasound and air_stripping in removing CCl4 and 1,1,1-TCA from water .
15811676	1	1,1,1-TCA	238,247	CCl4	205,209	1,1,1-TCA	CCl4	null	6351	Chemical	Gene	carbon_tetrachloride|appos|START_ENTITY carbon_tetrachloride|appos|END_ENTITY	Ultrasonic and air-stripping techniques for removal of carbon_tetrachloride -LRB- CCl4 -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- from water were studied in batch experiments .
23479748	4	1,1,1-TCA	1007,1016	DcrA	769,773	1,1,1-TCA	DcrA	null	10311	Chemical	Gene	CF|conj|START_ENTITY 1,1-dichloroethane|conj|CF dechlorinates|dobj|1,1-dichloroethane share|parataxis|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
23479748	4	1,1,1-TCA	1007,1016	DcrA	954,958	1,1,1-TCA	DcrA	null	10311	Chemical	Gene	CF|conj|START_ENTITY 1,1-dichloroethane|conj|CF dechlorinates|dobj|1,1-dichloroethane dechlorinates|nsubj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
23479748	4	1,1,1-TCA	914,923	DcrA	769,773	1,1,1-TCA	DcrA	null	10311	Chemical	Gene	1,1,1-trichloroethane|appos|START_ENTITY chloroform|conj|1,1,1-trichloroethane dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
23479748	4	1,1,1-TCA	914,923	DcrA	954,958	1,1,1-TCA	DcrA	null	10311	Chemical	Gene	1,1,1-trichloroethane|appos|START_ENTITY chloroform|conj|1,1,1-trichloroethane dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|parataxis|dechlorinates dechlorinates|nsubj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
17056695	11	1,1,1-TCA	1565,1574	KB-1	1481,1485	1,1,1-TCA	KB-1	null	390221	Chemical	Gene	present|nummod|START_ENTITY inhibited|nmod|present inhibited|nsubjpass|Dechlorination Dechlorination|nmod|END_ENTITY	Dechlorination of cis-dichloroethene -LRB- cDCE -RRB- and vinyl_chloride -LRB- VC -RRB- in KB-1 , a chloroethene-degrading culture used for bioaugmentation , was inhibited with 1,1,1-TCA present .
17056695	12	1,1,1-TCA	1682,1691	KB-1	1589,1593	1,1,1-TCA	KB-1	null	390221	Chemical	Gene	dechlorinated|nsubjpass|START_ENTITY demonstrated|advcl|dechlorinated proceeded|advcl|demonstrated proceeded|advcl|coinoculated coinoculated|nsubjpass|END_ENTITY	When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE .
17056695	12	1,1,1-TCA	1682,1691	KB-1	1786,1790	1,1,1-TCA	KB-1	null	390221	Chemical	Gene	dechlorinated|nsubjpass|START_ENTITY demonstrated|advcl|dechlorinated demonstrated|dobj|application application|nmod|cultures cultures|compound|MS MS|conj|END_ENTITY	When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE .
17056695	12	1,1,1-TCA	1851,1860	KB-1	1589,1593	1,1,1-TCA	KB-1	null	390221	Chemical	Gene	cocontaminated|nmod|START_ENTITY sites|acl|cocontaminated cobioaugmentation|nmod|sites demonstrated|nmod|cobioaugmentation proceeded|advcl|demonstrated proceeded|advcl|coinoculated coinoculated|nsubjpass|END_ENTITY	When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE .
17056695	12	1,1,1-TCA	1851,1860	KB-1	1786,1790	1,1,1-TCA	KB-1	null	390221	Chemical	Gene	cocontaminated|nmod|START_ENTITY sites|acl|cocontaminated cobioaugmentation|nmod|sites demonstrated|nmod|cobioaugmentation demonstrated|dobj|application application|nmod|cultures cultures|compound|MS MS|conj|END_ENTITY	When KB-1 and MS were coinoculated , degradation of cDCE and VC to ethene proceeded as soon as the 1,1,1-TCA was dechlorinated to 1,1-DCA by MS. This demonstrated the potential application of the MS and KB-1 cultures for cobioaugmentation of sites cocontaminated with 1,1,1-TCA and TCE .
23904257	8	1,1,1-TCA	1469,1478	NO3	1497,1500	1,1,1-TCA	NO3	null	4681	Chemical	Gene	removal|nummod|START_ENTITY removal|conj|END_ENTITY	HCO3 -LRB- - -RRB- anions had a accelerative effect on 1,1,1-TCA removal , and both NO3 -LRB- - -RRB- and HA had inhibitory effects .
28424844	6	1,1,1-TCA	1001,1010	THM1	918,922	1,1,1-TCA	THM1	null	79809	Chemical	Gene	chloroform|conj|START_ENTITY dehalogenation|nmod|chloroform found|nmod|dehalogenation found|nsubjpass|END_ENTITY	THM1 , was found to couple growth with dehalogenation of chloroform , bromoform , and 1,1,1-TCA .
28424844	7	1,1,1-TCA	1132,1141	THM1	1019,1023	1,1,1-TCA	THM1	null	79809	Chemical	Gene	dehalogenation|nummod|START_ENTITY chloroform|conj|dehalogenation catalyzes|dobj|chloroform ThmA|acl:relcl|catalyzes harbors|dobj|ThmA harbors|nsubj|END_ENTITY	Strain THM1 harbors a newly identified reductive dehalogenase -LRB- RDase -RRB- , ThmA , which catalyzes chloroform , bromoform , and 1,1,1-TCA dehalogenation .
28424844	7	1,1,1-TCA	1132,1141	ThmA	1083,1087	1,1,1-TCA	ThmA	null	117193	Chemical	Gene	dehalogenation|nummod|START_ENTITY chloroform|conj|dehalogenation catalyzes|dobj|chloroform END_ENTITY|acl:relcl|catalyzes	Strain THM1 harbors a newly identified reductive dehalogenase -LRB- RDase -RRB- , ThmA , which catalyzes chloroform , bromoform , and 1,1,1-TCA dehalogenation .
3245236	2	1,1,1-TCE	143,152	cytochrome_P-450	369,385	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	1,1,1-trichloroethane|appos|START_ENTITY action|nmod|1,1,1-trichloroethane studied|nsubjpass|action studied|nmod|determination determination|conj|change change|nmod|END_ENTITY	The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 .
3245236	2	1,1,1-TCE	315,324	cytochrome_P-450	369,385	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	metabolism|nummod|START_ENTITY consumption|conj|metabolism rates|nmod|consumption determination|nmod|rates determination|conj|change change|nmod|END_ENTITY	The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 .
3245236	8	1,1,1-TCE	780,789	cytochrome_P-450	799,815	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	Spectral studies indicated that 1,1,1-TCE bound to cytochrome_P-450 and showed a type I spectral change .
3988004	4	1,1,1-TCE	656,665	cytochrome_P-450	688,704	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	However , 1,1,1-TCE bound more tightly to cytochrome_P-450 and seemed to be only slowly metabolized compared to 1,1,2-TCE .
3988004	8	1,1,1-TCE	1388,1397	cytochrome_P-450	1401,1417	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	END_ENTITY|nummod|START_ENTITY	Considering our previous data indicating that TCE did not stimulate mitochondrial respiration , it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome_P-450 than the amount which was necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system .
3988004	8	1,1,1-TCE	1534,1543	cytochrome_P-450	1401,1417	1,1,1-TCE	cytochrome P-450	CHEBI:36015	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY due|nmod|effect due|nsubj|amount amount|nmod|consumption consumption|acl|associated associated|nmod|binding binding|nmod|END_ENTITY	Considering our previous data indicating that TCE did not stimulate mitochondrial respiration , it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome_P-450 than the amount which was necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system .
1489524	5	1,1,1-TCE	903,912	GPT	853,856	1,1,1-TCE	GPT	CHEBI:36015	81670(Tax:10116)	Chemical	Gene	did|nsubj|START_ENTITY serum|advcl|did led|nmod|serum led|nmod|END_ENTITY	It led to much higher values for GPT , SDH and GDH both in serum and perfusate than 1,1,1-TCE did -LRB- P < 0.01 -RRB- .
11090101	6	1,1,1-trichlorethane	541,561	NR1/2A	707,713	1,1,1-trichlorethane	NR1/2A	CHEBI:36015	397953;100127346	Chemical	Gene	benzene|dep|START_ENTITY solvents|dep|benzene effects|nmod|solvents report|nmod|effects report|nmod|currents currents|acl|measured measured|advcl|expressing expressing|dobj|subtypes subtypes|compound|END_ENTITY	We now report on the effects of other commonly abused solvents -LRB- benzene , m-xylene , ethylbenzene , propylbenzene , 1,1,1-trichlorethane -LRB- TCE -RRB- and those of a convulsive solvent , 2,2,2-trifluoroethyl _ ether -LRB- flurothyl -RRB- , on NMDA-induced currents measured in XENOPUS oocytes expressing NR1/2A or NR1/2B receptor subtypes .
11090101	6	1,1,1-trichlorethane	541,561	NR1/2B	717,723	1,1,1-trichlorethane	NR1/2B	CHEBI:36015	100126610(Tax:8355)	Chemical	Gene	benzene|dep|START_ENTITY solvents|dep|benzene effects|nmod|solvents report|nmod|effects report|nmod|currents currents|acl|measured measured|advcl|expressing expressing|dobj|subtypes subtypes|compound|NR1/2A NR1/2A|conj|END_ENTITY	We now report on the effects of other commonly abused solvents -LRB- benzene , m-xylene , ethylbenzene , propylbenzene , 1,1,1-trichlorethane -LRB- TCE -RRB- and those of a convulsive solvent , 2,2,2-trifluoroethyl _ ether -LRB- flurothyl -RRB- , on NMDA-induced currents measured in XENOPUS oocytes expressing NR1/2A or NR1/2B receptor subtypes .
11718349	1	1,1,1-trichloroethane	167,188	CCl4	150,154	1,1,1-trichloroethane	CCl4	MESH:C024566	6351	Chemical	Gene	END_ENTITY|conj|START_ENTITY	The reductive dehalogenation of gas-phase chlorinated_alkanes -LRB- CCl4 , CHCl3 , and 1,1,1-trichloroethane -RRB- and alkenes -LRB- perchloroethene -LRB- PCE -RRB- and trichloroethene -LRB- TCE -RRB- -RRB- was conducted in a modified fuel cell .
15811676	1	1,1,1-trichloroethane	215,236	CCl4	205,209	1,1,1-trichloroethane	CCl4	MESH:C024566	6351	Chemical	Gene	carbon_tetrachloride|conj|START_ENTITY carbon_tetrachloride|appos|END_ENTITY	Ultrasonic and air-stripping techniques for removal of carbon_tetrachloride -LRB- CCl4 -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- from water were studied in batch experiments .
8981595	1	1,1,1-trichloroethane	125,146	CD-1	209,213	1,1,1-trichloroethane	CD-1	MESH:C024566	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY examined|nsubjpass|effects examined|nmod|mice mice|compound|END_ENTITY	The effects of 1,1,1-trichloroethane -LRB- TCE -RRB- on physical and behavioral development were examined in CD-1 mice prenatally exposed under two regimens .
11521816	8	1,1,1-trichloroethane	1462,1483	cis-1	1638,1643	1,1,1-trichloroethane	cis-1	MESH:C024566	8651	Chemical	Gene	1,1-dichloroethane|amod|START_ENTITY conditions|amod|1,1-dichloroethane solutions|nmod|conditions Using|dobj|solutions Using|conj|chloroethane chloroethane|dobj|Consistent Consistent|amod|END_ENTITY	Using these analytical solutions , for the sulfate-reducing field conditions documented for this site , perchloroethene , trichloroethene , 1,1,1-trichloroethane , 1,1-dichloroethane , and chloroethane all degraded with half-lives ranging from 5 to 115 d. Consistent with other studies of sulfate-reducing conditions , cis-1 ,2 - dichloroethene did not chemically degrade at a measurable rate .
22071373	2	1,1,1-trichloroethane	409,430	cis-1	367,372	1,1,1-trichloroethane	cis-1	MESH:C024566	8651	Chemical	Gene	dichloroethylene|conj|START_ENTITY tetrachloroethylene|amod|dichloroethylene tetrachloroethylene|amod|END_ENTITY	The chlorinated compounds include tetrachloroethylene , trichloroethylene , cis-1 ,2 - dichloroethylene , vinyl_chloride , 1,1,1-trichloroethane , 1,1-dichloroethane , 1,2-dichloroethane , chloroethane , carbon_tetrachloride , chloroform , dichloromethane , and chloromethane .
6802168	6	1,1,1-trichloroethane	738,759	CO2	726,729	1,1,1-trichloroethane	CO2	MESH:C024566	717	Chemical	Gene	size|conj|START_ENTITY size|nmod|END_ENTITY	Also the Bohr dead space was found to be of similar size for CO2 and for 1,1,1-trichloroethane .
6594588	0	1,1,1-trichloroethane	36,57	Cyrano	0,6	1,1,1-trichloroethane	Cyrano	MESH:C024566	729082	Chemical	Gene	loved|xcomp|START_ENTITY loved|nsubj|Bergerac Bergerac|compound|END_ENTITY	Cyrano De Bergerac would have loved 1,1,1-trichloroethane .
10232850	6	1,1,1-trichloroethane	838,859	cytochrome_P450	907,922	1,1,1-trichloroethane	cytochrome P450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	means|nmod|START_ENTITY drug-induced|nmod|means compound|amod|drug-induced compound|acl:relcl|pseudosubstrate pseudosubstrate|nmod|END_ENTITY	This method was evaluated for the determination of drug-induced in vivo generation of oxidative stress by means of 1,1,1-trichloroethane -LRB- TCE -RRB- a compound that is a pseudosubstrate for cytochrome_P450 and is known to induce oxygen reductase activity of this enzyme -LRB- s -RRB- .
3245236	2	1,1,1-trichloroethane	120,141	cytochrome_P-450	369,385	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY studied|nsubjpass|action studied|nmod|determination determination|conj|change change|nmod|END_ENTITY	The action of 1,1,1-trichloroethane -LRB- 1,1,1-TCE -RRB- on cytochrome_P-450-dependent mixed-function oxidation by rat liver microsomes was studied by determination of the rates of O2 consumption , H2O2 production , and 1,1,1-TCE metabolism , and from the spectral change in cytochrome_P-450 .
3988004	1	1,1,1-trichloroethane	118,139	cytochrome_P-450	165,181	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	START_ENTITY|conj|1,1,2-TCE 1,1,2-TCE|nmod|END_ENTITY	The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital .
3988004	1	1,1,1-trichloroethane	118,139	cytochrome_P-450	261,277	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY observed|nsubjpass|interactions observed|xcomp|using using|xcomp|measure measure|dobj|changes changes|nmod|END_ENTITY	The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital .
578726	7	1,1,1-trichloroethane	1075,1096	cytochrome_P-450	1142,1158	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY depressed|nsubj|exposure depressed|dobj|content content|amod|END_ENTITY	The exposure to 1,1,1-trichloroethane on the 5th day depressed also the microsomal cytochrome_P-450 content in liver of rats whereas trichloroethylene increased the hemochrome content slightly at the same time .
6722974	1	1,1,1-trichloroethane	87,108	cytochrome_P-450	183,199	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	1,2-Dichloroethane|amod|START_ENTITY metabolized|nsubjpass|1,2-Dichloroethane metabolized|nmod|END_ENTITY	1,2-Dichloroethane , 1,1,1-trichloroethane and 1,1,2,2-tetrachloroethane appear to be metabolized by hepatic nuclear cytochrome_P-450 .
6722974	5	1,1,1-trichloroethane	723,744	cytochrome_P-450	869,885	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	25251(Tax:10116)	Chemical	Gene	2,2,2-trichloroethanol|advcl|START_ENTITY 1,2-dichloroethane|conj|2,2,2-trichloroethanol chloroacetaldehyde|acl|1,2-dichloroethane produced|nsubjpass|chloroacetaldehyde produced|nmod|END_ENTITY	chloroacetaldehyde from 1,2-dichloroethane , 2,2,2-trichloroethanol from 1,1,1-trichloroethane , and dichloroacetic_acid from 1,1,2,2-tetrachloroethane , were also produced from the three chloroalkanes by hepatic nuclear cytochrome_P-450 .
7285278	4	1,1,1-trichloroethane	623,644	cytochrome_P-450	706,722	1,1,1-trichloroethane	cytochrome P-450	MESH:C024566	4051	Chemical	Gene	2,2,2-trichloroethanol|nsubj|START_ENTITY 2,2,2-trichloroethanol|nmod|END_ENTITY	1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively .
23479748	4	1,1,1-trichloroethane	891,912	DcrA	769,773	1,1,1-trichloroethane	DcrA	MESH:C024566	10311	Chemical	Gene	chloroform|conj|START_ENTITY dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|nsubj|identified identified|acl|annotated annotated|nmod|CfrA CfrA|conj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
23479748	4	1,1,1-trichloroethane	891,912	DcrA	954,958	1,1,1-trichloroethane	DcrA	MESH:C024566	10311	Chemical	Gene	chloroform|conj|START_ENTITY dechlorinates|dobj|chloroform share|ccomp|dechlorinates share|parataxis|dechlorinates dechlorinates|nsubj|END_ENTITY	The two RDases identified , annotated as CfrA and DcrA , share an amino_acid identity of 95.2 per cent , but use different substrates : CfrA dechlorinates chloroform -LRB- CF -RRB- and 1,1,1-trichloroethane -LRB- 1,1,1-TCA -RRB- , but not 1,1-dichloroethane ; DcrA dechlorinates 1,1-dichloroethane , but not CF or 1,1,1-TCA .
20123932	1	1,1,1-trichloroethane	322,343	GABAA	148,153	1,1,1-trichloroethane	GABAA	MESH:C024566	14405(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY transduction|nmod|effects systems|nmod|transduction involvement|conj|systems involvement|nmod|END_ENTITY	The present study examined the involvement of the GABAA , N-methyl-D-aspartate -LRB- NMDA -RRB- , nicotinic acetylcholine , and mu-opioid receptor systems in the transduction of the discriminative stimulus effects of the abused inhalant 1,1,1-trichloroethane -LRB- TCE -RRB- .
12602951	2	1,1,1-trichloroethane	555,576	GMIPp	294,299	1,1,1-trichloroethane	GMIPp	MESH:C024566	51291	Chemical	Gene	determined|advcl|START_ENTITY acceptors|acl|determined basicities|nmod|acceptors acidities|conj|basicities made|dobj|acidities made|nsubjpass|Comparison Comparison|nmod|values values|compound|END_ENTITY	Comparison of the GMIPp values is made with two experimental hydrogen-bond scales : i -RRB- the hydrogen-bond basicity scale for N-heteroaromatics in carbon_tetrachloride , and ii -RRB- the hydrogen-bond acidities for NH/OH donors and hydrogen-bond basicities of N/O acceptors determined in 1,1,1-trichloroethane .
1463393	3	1,1,1-trichloroethane	880,901	GPT	944,947	1,1,1-trichloroethane	GPT	MESH:C024566	81670(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY ppm|dobj|increase ppm|nmod|activity activity|compound|END_ENTITY	In contrast , coadministration of 50 ppm trichloroethylene and 200 ppm 1,1,1-trichloroethane decreased CCl4-induced increase in plasma GPT activity , though these exposures did not influence the liver MDA content .
11379082	2	1,1,1-trichloroethane	423,444	GroEL	476,481	1,1,1-trichloroethane	GroEL	MESH:C024566	3329	Chemical	Gene	benzoquinone|conj|START_ENTITY benzoquinone|dep|expression expression|compound|END_ENTITY	At the EC25 concentration , pentachlorophenol -LRB- PCP -RRB- , cadmium , nickel , 2,4-dichloroaniline , benzoquinone , 2,4-dinitrophenol , and 1,1,1-trichloroethane all rapidly induced measurable GroEL expression , even though the time-dependent response for each of these compounds was somewhat varied .
10541915	8	1,1,1-trichloroethane	968,989	IL-1beta	991,999	1,1,1-trichloroethane	IL-1beta	MESH:C024566	3553	Chemical	Gene	82.4|amod|START_ENTITY 82.4|compound|END_ENTITY	RESULTS : Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane -LRB- IL-1beta 82.4 vs. 28.8 pg/ml -LRB- medians -RRB- , P = 0.003 ; IL-6 12.2 vs. 7.2 pg/ml , P = 0 .
10541915	8	1,1,1-trichloroethane	968,989	IL-6	1040,1044	1,1,1-trichloroethane	IL-6	MESH:C024566	3569	Chemical	Gene	82.4|amod|START_ENTITY 82.4|appos|P P|dep|END_ENTITY	RESULTS : Concentrations of ILs were significantly elevated after exposure to 200 ppm 1,1,1-trichloroethane -LRB- IL-1beta 82.4 vs. 28.8 pg/ml -LRB- medians -RRB- , P = 0.003 ; IL-6 12.2 vs. 7.2 pg/ml , P = 0 .
16404204	5	1,1,1-trichloroethane	669,690	JP4	696,699	1,1,1-trichloroethane	JP4	MESH:C024566	84502	Chemical	Gene	START_ENTITY|conj|gasoline gasoline|compound|END_ENTITY	RESULTS : For the 1973-2000 period , there was an approximate twofold increased risk of ESRD among workers exposed to trichloroethylene , 1,1,1-trichloroethane , and JP4 gasoline compared with unexposed subjects -LRB- all P < 0.05 -RRB- .
9237768	6	1,1,1-trichloroethane	859,880	JP-4	852,856	1,1,1-trichloroethane	JP-4	MESH:C024566	84502	Chemical	Gene	fuel|amod|START_ENTITY fuel|appos|END_ENTITY	Sister-chromatid_exchanges -LRB- SCE -RRB- and micronuclei -LRB- MN -RRB- frequency were measured in conjunction with air sampling and expired breath analysis for jet fuel -LRB- JP-4 -RRB- , 1,1,1-trichloroethane , methyl_ethyl_ketone , xylenes , toluene and methylene_chloride .
11409535	1	1,1,1-trichloroethane	271,292	PERC	260,264	1,1,1-trichloroethane	PERC	MESH:C024566	291567(Tax:10116)	Chemical	Gene	trichloroethylene|conj|START_ENTITY trichloroethylene|conj|tetrachloroethylene tetrachloroethylene|appos|perchloroethylene perchloroethylene|dep|END_ENTITY	The volatile organic solvents trichloroethylene -LRB- TCE -RRB- , tetrachloroethylene -LRB- perchloroethylene , PERC -RRB- , and 1,1,1-trichloroethane -LRB- methylchloroform , MC -RRB- are widely distributed environmental pollutants and common contaminants of many chemical waste sites .
24910396	1	1,1,1-trichloroethane	279,300	PERC	359,363	1,1,1-trichloroethane	PERC	MESH:C024566	170826(Tax:10090)	Chemical	Gene	1,2-dichloroethane|conj|START_ENTITY effects|acl|1,2-dichloroethane profiles|nmod|effects profiles|appos|END_ENTITY	The present study aimed to clarify whether dose-response profiles of acute behavioral effects of 1,2-dichloroethane -LRB- DCE -RRB- , 1,1,1-trichloroethane -LRB- TCE -RRB- , trichloroethylene -LRB- TRIC -RRB- , and tetrachloroethylene -LRB- PERC -RRB- differ .
19005803	2	1,1,1-trichloroethane	366,387	R12	494,497	1,1,1-trichloroethane	R12	MESH:C024566	2840	Chemical	Gene	VCCs|amod|START_ENTITY VCCs|conj|CFCs CFCs|dep|trichlorofluoromethane trichlorofluoromethane|conj|dichlorodifluoromethane dichlorodifluoromethane|dep|END_ENTITY	Fully halogenated VCCs -LRB- tetrachloroethylene , 1,1,1-trichloroethane , tetrachloromethane and dichloromethane -RRB- and CFCs -LRB- trichlorofluoromethane -LRB- R11 -RRB- , dichlorodifluoromethane -LRB- R12 -RRB- and 1,1,2-trichlorotrifluoroethane -LRB- R113 -RRB- -RRB- were degraded under anaerobic conditions in addition to the methanogenic bacteria in municipal solid waste -LRB- MSW -RRB- and organic wastes .
2874801	5	1,1,1-trichloroethane	660,681	sec-1	784,789	1,1,1-trichloroethane	sec-1	MESH:C024566	653677	Chemical	Gene	PEG-hemin|nmod|START_ENTITY activity|nmod|PEG-hemin greater|nsubj|activity greater|parataxis|X X|amod|END_ENTITY	The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide .
2874801	5	1,1,1-trichloroethane	660,681	sec-1	926,931	1,1,1-trichloroethane	sec-1	MESH:C024566	653677	Chemical	Gene	PEG-hemin|nmod|START_ENTITY activity|nmod|PEG-hemin greater|nsubj|activity greater|parataxis|X X|conj|END_ENTITY	The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide .
2874801	5	1,1,1-trichloroethane	741,762	sec-1	784,789	1,1,1-trichloroethane	sec-1	MESH:C024566	653677	Chemical	Gene	values|nmod|START_ENTITY X|nsubj|values X|amod|END_ENTITY	The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide .
2874801	5	1,1,1-trichloroethane	741,762	sec-1	926,931	1,1,1-trichloroethane	sec-1	MESH:C024566	653677	Chemical	Gene	values|nmod|START_ENTITY X|nsubj|values X|conj|END_ENTITY	The activity of PEG-hemin in 1,1,1-trichloroethane was greater than that in an aqueous solution ; k1 values in 1,1,1-trichloroethane were 2.3 X 10 -LRB- 3 -RRB- M-1 sec-1 with hydrogen_peroxide and 7.0 X 10 -LRB- 2 -RRB- M-1 sec-1 with peroxidized linolenic_acid , and the value in an aqueous solution was 3.0 X_10_M-1 sec-1 with hydrogen_peroxide .
10508110	2	1,1,1-trichloroethane	102,123	TA5	150,153	1,1,1-trichloroethane	TA5	MESH:C024566	83551	Chemical	Gene	strains|nmod|START_ENTITY strains|dep|bacteria bacteria|conj|END_ENTITY	Two strains of 1,1,1-trichloroethane -LRB- TCA -RRB- - degrading bacteria , TA5 and TA27 , were isolated from soil and identified as Mycobacterium spp .
2139502	6	1.1.1-trichloroethane	728,749	PCB	809,812	1.1.1-trichloroethane	PCB	MESH:C024566	5091	Chemical	Gene	toluene|conj|START_ENTITY toluene|conj|END_ENTITY	An approach in setting standards of indoor air quality for frequent organic substances like toluene , xylene , styrene , dichloromethane , 1.1.1-trichloroethane , trichloroethene , tetrachloroethene , pentachlorophenol and PCB is presented , incorporating adequate protection margins .
27328667	1	1,1,1-trifluoro-2-iodoethane	199,227	C-3	136,139	1,1,1-trifluoro-2-iodoethane	C-3	MESH:C000591752	718	Chemical	Gene	using|xcomp|START_ENTITY imidazoheterocycles|acl|using trifluoroethylation|nmod|imidazoheterocycles trifluoroethylation|amod|selective selective|amod|END_ENTITY	UNASSIGNED : A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed .
18717564	1	1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one	243,299	III	219,222	1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one	III	null	25021114	Chemical	Gene	-RSB-|dep|START_ENTITY 6|amod|-RSB- synthesized|nsubjpass|6 4|acl:relcl|synthesized 3Co|dep|4 3Co|appos|END_ENTITY	A mixed-valence Co -LRB- II -RRB- / Co -LRB- III -RRB- heptanuclear wheel -LSB- Co -LRB- II -RRB- 3Co -LRB- III -RRB- 4 -LRB- L -RRB- 6 -LRB- MeO -RRB- 6 -RSB- -LRB- LH2 = 1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one -RRB- has been synthesized and its crystal structure determined using single-crystal X-ray diffraction .
8055254	3	1,1,1-trifluorotetradecan-2-one	660,691	EAG	782,785	1,1,1-trifluorotetradecan-2-one	EAG	null	3756	Chemical	Gene	-16|conj|START_ENTITY carried|xcomp|-16 carried|parataxis|displayed displayed|nmod|END_ENTITY	In the laboratory experiments , carried out by pre-exposure of males to vapors of the chemicals , alpha-naphthyl_trifluoromethyl_ketone , beta-naphthyl_trifluoromethyl_ketone , 1,1,1-trifluorotetradecan-2-one and -LRB- Z -RRB- -16 - nonadecen-14-yn-2-one displayed notable blockage of the pheromone detection on EAG .
3941075	3	11-21	425,430	myosin	480,486	11-21	myosin	MESH:C065619	79784	Chemical	Gene	peptides|nummod|START_ENTITY phosphorylated|nsubjpass|peptides phosphorylated|nmod|chain chain|compound|END_ENTITY	The peptides 11-19 , 11-20 , 11-21 , 11-22 , and 11-23 were all phosphorylated by the myosin light chain kinase with similar apparent Km values in the range 11-17 microM .
824867	3	1,1,2,2-tetrachloroethane	269,294	CCl4	381,385	1,1,2,2-tetrachloroethane	CCl4	MESH:C015530	116637(Tax:10116)	Chemical	Gene	given|nsubjpass|START_ENTITY given|nmod|level level|amod|equivalent equivalent|nmod|quarter quarter|nmod|that that|nmod|END_ENTITY	Due to high toxicity , 1,1,2,2-tetrachloroethane and pentachloroethane were given at a dose level equivalent to one quarter of that of CCl4 and the other chlorohydrocarbons -LRB- i.e. 2-6 mmol/kg -RRB- .
824867	8	1,1,2,2-tetrachloroethane	789,814	CCl4	783,787	1,1,2,2-tetrachloroethane	CCl4	MESH:C015530	116637(Tax:10116)	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Expoxide hydratase activity in rat liver declined significantly after CCl4 , 1,1,2,2-tetrachloroethane and pentachloroethane administrations .
3426575	1	1,1,2,2-tetrachloroethane	158,183	cytochrome_P-450	263,279	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY investigated|nsubjpass|oxidation investigated|conj|purified purified|xcomp|END_ENTITY	The oxidation of 1,1,2,2-tetrachloroethane to dichloroacetic_acid was investigated with rat liver microsomes and purified cytochrome_P-450 .
6128194	6	1,1,2,2-tetrachloroethane	1186,1211	cytochrome_P-450	1230,1246	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	metabolized|nsubjpass|START_ENTITY metabolized|advcl|END_ENTITY	The results are consistent with a scheme whereby 1,1,2,2-tetrachloroethane is metabolized by cytochrome_P-450 to dichloroacetyl_chloride , which can bind covalently to various nucleophiles or hydrolyze to dichloroacetic_acid .
6722974	10	1,1,2,2-tetrachloroethane	1799,1824	cytochrome_P-450	1650,1666	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	1,2-dichloroethane|conj|START_ENTITY metabolism|acl|1,2-dichloroethane mediate|nsubj|metabolism mediate|advcl|exceed exceed|nsubj|metabolism metabolism|amod|dependent dependent|amod|END_ENTITY	It is proposed that , although the cytochrome_P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei , the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome_P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds .
6722974	10	1,1,2,2-tetrachloroethane	1799,1824	cytochrome_P-450	1836,1852	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	1,2-dichloroethane|conj|START_ENTITY metabolism|acl|1,2-dichloroethane metabolism|nmod|END_ENTITY	It is proposed that , although the cytochrome_P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei , the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome_P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds .
6722974	1	1,1,2,2-tetrachloroethane	113,138	cytochrome_P-450	183,199	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	1,1,1-trichloroethane|conj|START_ENTITY 1,2-Dichloroethane|amod|1,1,1-trichloroethane metabolized|nsubjpass|1,2-Dichloroethane metabolized|nmod|END_ENTITY	1,2-Dichloroethane , 1,1,1-trichloroethane and 1,1,2,2-tetrachloroethane appear to be metabolized by hepatic nuclear cytochrome_P-450 .
6722974	5	1,1,2,2-tetrachloroethane	775,800	cytochrome_P-450	869,885	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	25251(Tax:10116)	Chemical	Gene	dichloroacetic_acid|advcl|START_ENTITY 1,2-dichloroethane|conj|dichloroacetic_acid chloroacetaldehyde|acl|1,2-dichloroethane produced|nsubjpass|chloroacetaldehyde produced|nmod|END_ENTITY	chloroacetaldehyde from 1,2-dichloroethane , 2,2,2-trichloroethanol from 1,1,1-trichloroethane , and dichloroacetic_acid from 1,1,2,2-tetrachloroethane , were also produced from the three chloroalkanes by hepatic nuclear cytochrome_P-450 .
7285278	4	1,1,2,2-tetrachloroethane	781,806	cytochrome_P-450	706,722	1,1,2,2-tetrachloroethane	cytochrome P-450	MESH:C015530	4051	Chemical	Gene	1,1,2-trichloroethane|conj|START_ENTITY metabolites|acl|1,1,2-trichloroethane mono|nsubj|metabolites converted|advcl|mono converted|xcomp|2,2,2-trichloroethanol 2,2,2-trichloroethanol|nmod|END_ENTITY	1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively .
11944690	2	1,1,2,2-tetrachloroethane	341,366	exo-1	510,515	1,1,2,2-tetrachloroethane	exo-1	MESH:C015530	9156	Chemical	Gene	occurred|advcl|START_ENTITY occurred|dep|,7 ,7|dep|epoxy-1 epoxy-1|dep|,4:5,8 ,4:5,8|amod|END_ENTITY	Dehydrohalogenation -LRB- loss of HCI with the formation of a double bond -RRB- occurred at temperatures as low as 105-200 degrees C for 1,1,2,2-tetrachloroethane , lindane -LRB- 1,2,3,4,5,6-hexachlorocyclohexane , gamma-isomer -RRB- , and dieldrin -LRB- 1,2,3,4,10,10-hexachloro-6 ,7 - epoxy-1 ,4,4 a,5,6,7,8,8a-octahydro-endo , _ exo-1 ,4:5,8 - dimethanonaphthalene -RRB- .
3389679	2	1,1,2,2-tetrachloroethane	771,796	GGT	895,898	1,1,2,2-tetrachloroethane	GGT	MESH:C015530	116568(Tax:10116)	Chemical	Gene	initiation|conj|START_ENTITY administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY	When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels .
9657282	2	1,1,2,2-tetrafluoroethyl-L-cysteine	255,290	TFEC	292,296	1,1,2,2-tetrafluoroethyl-L-cysteine	TFEC	null	26296(Tax:10116)	Chemical	Gene	START_ENTITY|appos|END_ENTITY	In this study , we have examined the ability of a single i.p. dose of 1,1,2,2-tetrafluoroethyl-L-cysteine -LRB- TFEC -RRB- , a major metabolite of tetrafluoroethylene , to produce hepatic and renal_injury in male and female rats .
3389679	2	1,1,2,2-TTCE	798,810	GGT	895,898	1,1,2,2-TTCE	GGT	null	116568(Tax:10116)	Chemical	Gene	1,1,2,2-tetrachloroethane|dep|START_ENTITY initiation|conj|1,1,2,2-tetrachloroethane administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY	When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels .
3389679	3	1,1,2,2-TTCE	927,939	GGT	999,1002	1,1,2,2-TTCE	GGT	null	116568(Tax:10116)	Chemical	Gene	START_ENTITY|dep|increases increases|nmod|+ +|compound|END_ENTITY	1,1,2,2-TTCE , TTCY , and 1,1,2-TCE also induced significant increases in GGT + - foci when administered in the promotion protocol without DEN initiation .
24677167	2	1,1,2,3,3-pentamethylenepropane	300,331	DR1	378,381	1,1,2,3,3-pentamethylenepropane	DR1	null	1810	Chemical	Gene	diradicals|amod|START_ENTITY analogues|nmod|diradicals analogues|dep|nitronyl_nitroxide nitronyl_nitroxide|appos|END_ENTITY	We succeeded in synthesising heteroatom analogues of the 1,1,2,3,3-pentamethylenepropane -LRB- PMP -RRB- diradicals with two nitronyl_nitroxide -LRB- DR1 -RRB- and with two iminonitroxide -LRB- DR2 -RRB- fragments linked through the C -LRB- sp2 -RRB- atom of the nitrone group .
1846198	2	1,123-amino-acid	329,345	UL37	309,313	1,123-amino-acid	UL37	null	2703358(Tax:10298)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The UL37 gene encodes a 1,123-amino-acid protein of unknown function , while the 465-amino-acid UL38 protein is involved in capsid assembly .
1846198	2	1,123-amino-acid	329,345	UL38	400,404	1,123-amino-acid	UL38	null	2703359(Tax:10298)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|advcl|involved involved|nsubjpass|protein protein|compound|END_ENTITY	The UL37 gene encodes a 1,123-amino-acid protein of unknown function , while the 465-amino-acid UL38 protein is involved in capsid assembly .
8822954	6	1124ACA	1195,1202	GPI	1155,1158	1124ACA	GPI	null	2821	Chemical	Gene	heterozygote|nmod|START_ENTITY Kinki|nmod|heterozygote Kinki|compound|END_ENTITY	We also identified GPI Kinki as a compound heterozygote of 1124ACA -- > AGA -LRB- 375Thr -- > Arg -RRB- / 1615GAC -- > AAC -LRB- 539Asp -- > Asn -RRB- .
15107826	4	1125A	687,692	SEP15	660,665	1125A	SEP15	null	9403	Chemical	Gene	variant|amod|START_ENTITY variant|compound|END_ENTITY	A SEP15 polymorphic variant , 1125A , resides in the SECIS recognition element in the 3 ' - UTR and may influence the efficiency of Sec incorporation into the protein during translation .
7506556	3	1125H	570,575	CD4	559,562	1125H	CD4	null	920	Chemical	Gene	END_ENTITY|conj|START_ENTITY	This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site .
7506556	3	1125H	570,575	gp120	494,499	1125H	gp120	null	3700	Chemical	Gene	CD4|conj|START_ENTITY inhibited|nmod|CD4 overlaps|advcl|inhibited overlaps|dobj|site site|nmod|END_ENTITY	This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site .
7506556	3	1125H	570,575	gp120	529,534	1125H	gp120	null	3700	Chemical	Gene	CD4|conj|START_ENTITY inhibited|nmod|CD4 inhibited|nsubjpass|binding binding|nmod|END_ENTITY	This epitope overlaps the CD4-binding site of gp120 , because binding of 5145A to gp120 is inhibited by soluble CD4 and by 1125H , a previously described HuMAb directed toward the CD4-binding site .
7506556	4	1125H	693,698	gp120	850,855	1125H	gp120	null	3700	Chemical	Gene	those|nmod|START_ENTITY those|conj|HuMAbs HuMAbs|acl|described described|advcl|documented documented|conj|reactivity reactivity|nmod|panel panel|nmod|mutants mutants|amod|END_ENTITY	However , the 5145A epitope differs from those of 1125H and other anti-CD4-binding site HuMAbs previously described , as documented by the viral strain specificity of 5145A and its reactivity with a panel of gp120 mutants .
21264442	9	11276A	1705,1711	F12	1631,1634	11276A	F12	null	2161	Chemical	Gene	F12|nmod|START_ENTITY produced|nsubj|F12 led|conj|produced led|nsubj|9775G_to_C 9775G_to_C|conj|11276G 11276G|nmod|mutations mutations|nmod|END_ENTITY	In conclusion , the 9775G_to_C and 11276G to A mutations of F12 led to a CRM-negative and - positive FXII_deficiency , and the F12 with 11276A produced a dysfunctional type of FXII with a partial defect -LRB- 0.41-0 .45 -RRB- in prekallikrein cleavage activity .
21264442	9	11276A	1705,1711	F12	1696,1699	11276A	F12	null	2161	Chemical	Gene	END_ENTITY|nmod|START_ENTITY	In conclusion , the 9775G_to_C and 11276G to A mutations of F12 led to a CRM-negative and - positive FXII_deficiency , and the F12 with 11276A produced a dysfunctional type of FXII with a partial defect -LRB- 0.41-0 .45 -RRB- in prekallikrein cleavage activity .
10760578	1	112-amino_acid	61,75	Elongin_A	150,159	112-amino acid	Elongin A	MESH:C045451	855491(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY protein|acl:relcl|binds binds|nmod|SIII SIII|conj|END_ENTITY	Mammalian Elongin_C is a 112-amino_acid protein that binds to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor and to Elongin_A , the transcriptionally active subunit of the RNA polymerase II elongation factor , SIII .
10760578	1	112-amino_acid	61,75	Elongin_C	46,55	112-amino acid	Elongin C	MESH:C045451	856061(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Mammalian Elongin_C is a 112-amino_acid protein that binds to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor and to Elongin_A , the transcriptionally active subunit of the RNA polymerase II elongation factor , SIII .
9341197	1	112-amino_acid	131,145	Elongin_C	116,125	112-amino acid	Elongin C	MESH:C045451	6921	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein .
9341197	1	112-amino_acid	131,145	VHL	368,371	112-amino acid	VHL	MESH:C045451	7428	Chemical	Gene	protein|amod|START_ENTITY protein|acl:relcl|found found|nmod|subunit subunit|conj|containing containing|advcl|_ _|nsubj|_ _|appos|END_ENTITY	Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein .
9341197	1	112-amino_acid	131,145	von_Hippel-Lindau	349,366	112-amino acid	von Hippel-Lindau	MESH:C045451	7428	Chemical	Gene	protein|amod|START_ENTITY protein|acl:relcl|found found|nmod|subunit subunit|conj|containing containing|advcl|_ _|nsubj|_ _|amod|END_ENTITY	Elongin_C is a 112-amino_acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin -LRB- SIII -RRB- and as a component of a multiprotein complex containing the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor protein .
1549120	3	112-amino-acid	549,563	TGF-beta	515,523	112-amino-acid	TGF-beta	null	7040	Chemical	Gene	polypeptide|amod|START_ENTITY homodimer|nmod|polypeptide homodimer|nsubj|form form|amod|END_ENTITY	Each TGF-beta form is a homodimer of a 112-amino-acid polypeptide which is encoded as a larger polypeptide precursor .
10731035	9	1,12-DD	1174,1181	Ornithine_decarboxylase	1061,1084	1,12-DD	Ornithine decarboxylase	null	24609(Tax:10116)	Chemical	Gene	reduced|nmod|START_ENTITY reduced|nsubjpass|activity activity|amod|END_ENTITY	Ornithine_decarboxylase activity as well as the concentration of internal polyamines were found to be reduced by 1,12-DD .
16519678	3	1,12-diaminododecane	561,581	PAO	478,481	1,12-diaminododecane	PAO	MESH:C016417	212503(Tax:10090)	Chemical	Gene	1,8-diaminooctane|dep|START_ENTITY analogues|xcomp|1,8-diaminooctane analogues|nsubj|study study|nmod|END_ENTITY	Here , a comparative study on murine PAO -LRB- mPAO -RRB- and SMO -LRB- mSMO -RRB- inhibition by the polyamine analogues 1,8-diaminooctane , 1,12-diaminododecane , N-prenylagmatine -LRB- G3 -RRB- , guazatine and N,N1-bis -LRB- 2,3-butadienyl -RRB- -1,4 - butanediamine -LRB- MDL72527 -RRB- is reported .
16519678	3	1,12-diaminododecane	561,581	SMO	493,496	1,12-diaminododecane	SMO	MESH:C016417	54498	Chemical	Gene	1,8-diaminooctane|dep|START_ENTITY analogues|xcomp|1,8-diaminooctane analogues|nsubj|study study|nmod|PAO PAO|conj|END_ENTITY	Here , a comparative study on murine PAO -LRB- mPAO -RRB- and SMO -LRB- mSMO -RRB- inhibition by the polyamine analogues 1,8-diaminooctane , 1,12-diaminododecane , N-prenylagmatine -LRB- G3 -RRB- , guazatine and N,N1-bis -LRB- 2,3-butadienyl -RRB- -1,4 - butanediamine -LRB- MDL72527 -RRB- is reported .
24881569	1	1,12-dicarba-closo-dodecaborane	162,193	fibronectin	353,364	1,12-dicarba-closo-dodecaborane	fibronectin	null	2335	Chemical	Gene	cluster|amod|START_ENTITY cluster|nmod|6-N 6-N|appos|activity activity|dep|C C|conj|adherence adherence|nmod|END_ENTITY	An impact of adenosine modification with electroneutral , lipophilic 1,12-dicarba-closo-dodecaborane or electronegative 7,8-dicarba-nido-undecaborane boron cluster at the 6-N , 2 ' - C and 2-C positions on human neutrophil oxidative burst , neutrophil adherence to fibronectin and protein kinase C activity was studied .
17676909	5	1,12-dimethyl	975,988	C-7	1027,1030	1,12-dimethyl	C-7	null	730	Chemical	Gene	observed|nmod|START_ENTITY observed|ccomp|carbocation carbocation|amod|protonated protonated|amod|END_ENTITY	With 3,9-dimethyl -LRB- 14 -RRB- , C-7 protonation -LRB- 14H + -RRB- is strongly favored -LRB- with < 10 % protonation at C-12 -RRB- , and with 1,12-dimethyl -LRB- 15 -RRB- the sole species observed is the C-7 protonated carbocation -LRB- 15H + -RRB- .
17676909	5	1,12-dimethyl	975,988	C-7	890,893	1,12-dimethyl	C-7	null	730	Chemical	Gene	observed|nmod|START_ENTITY favored|conj|observed favored|nsubj|protonation protonation|compound|END_ENTITY	With 3,9-dimethyl -LRB- 14 -RRB- , C-7 protonation -LRB- 14H + -RRB- is strongly favored -LRB- with < 10 % protonation at C-12 -RRB- , and with 1,12-dimethyl -LRB- 15 -RRB- the sole species observed is the C-7 protonated carbocation -LRB- 15H + -RRB- .
7559809	2	1,12-dimethylspermine	392,413	SSAT	453,457	1,12-dimethylspermine	SSAT	MESH:C073195	6303	Chemical	Gene	analogue|appos|START_ENTITY produces|nsubj|analogue produces|dobj|induction induction|nmod|END_ENTITY	We now report that one polyamine analogue , 1,12-dimethylspermine -LRB- DMSpm -RRB- , produces a large induction of SSAT with no significant effects on growth in the human large_cell_lung_carcinoma line , NCl H157 .
25305783	1	1,12-DoDDMA	286,297	TERP	463,467	1,12-DoDDMA	TERP	null	55825	Chemical	Gene	dimethacrylate|dep|START_ENTITY i.e.|appos|dimethacrylate based|nmod|i.e. liquid|acl:relcl|based synthesized|nsubjpass|liquid synthesized|xcomp|using using|dobj|polymerization polymerization|appos|END_ENTITY	New monolithic reversed-phase liquid chromatography -LRB- RPLC -RRB- stationary phases based on single multi-acrylate/methacrylate-containing monomers -LSB- i.e. , 1,12-dodecanediol _ dimethacrylate -LRB- 1,12-DoDDMA -RRB- , trimethylolpropane_trimethacrylate -LRB- TRIM -RRB- and pentaerythritol_tetraacrylate -LRB- PETA -RRB- -RSB- were synthesized using organotellurium-mediated living radical polymerization -LRB- TERP -RRB- , which was expected to produce more efficient monolithic columns than conventional free-radical polymerization .
23122321	4	1,12-dodecanediamine	788,808	C10	704,707	1,12-dodecanediamine	C10	MESH:C016417	3226	Chemical	Gene	residues|amod|START_ENTITY derived|nmod|residues amide-diamines|acl|derived polyamides|conj|amide-diamines polyamides|acl|derived derived|nmod|END_ENTITY	Furthermore , polyamides -LRB- PAs -RRB- derived from C10 and C14 dicarboxylic_acids and amide-diamines derived from 1,6-hexanediamine or 1,12-dodecanediamine and L-phenylalanine , L-valyl-L-phenylalanine or L-phenylalanyl-L-valine residues have been reported as biocompatible polymers .
26335988	4	1,12-dodecanediol	958,975	APE1	905,909	1,12-dodecanediol	APE1	null	328	Chemical	Gene	loop|amod|START_ENTITY using|nmod|loop distinguish|advcl|using distinguish|nmod|activity activity|nmod|END_ENTITY	In the present study we demonstrate a highly specific real-time detection of the AP-site cleaving activity of Tdp1 which allows one to distinguish it from the activity of APE1 by using a short hairpin oligonucleotide with a 1,12-dodecanediol loop , a 5 ' - fluorophore and a 3 ' - quencher .
26335988	4	1,12-dodecanediol	958,975	Tdp1	844,848	1,12-dodecanediol	Tdp1	null	55775	Chemical	Gene	loop|amod|START_ENTITY using|nmod|loop distinguish|advcl|using allows|xcomp|distinguish END_ENTITY|acl:relcl|allows	In the present study we demonstrate a highly specific real-time detection of the AP-site cleaving activity of Tdp1 which allows one to distinguish it from the activity of APE1 by using a short hairpin oligonucleotide with a 1,12-dodecanediol loop , a 5 ' - fluorophore and a 3 ' - quencher .
7150629	5	1,1-2H2	992,999	C-2	818,821	1,1-2H2	C-2	null	24231(Tax:10116)	Chemical	Gene	administration|nummod|START_ENTITY -LSB-|dobj|administration h|acl|-LSB- 2.7-4|nmod|h 2.7-4|nsubj|content content|nmod|END_ENTITY	The total deuterium content at C-2 and C-3 of the glycerol moiety of 1-alkyl-2-acyl - _ and_1-alk-1 ' - enyl-2-acyl-sn-glycero-3-phosphocholines was 2.7-4 .4 atom % and 0.3-0 .8 atom % , respectively , after 48 h of -LSB- 1,1-2H2 -RSB- ethanol administration .
7150629	5	1,1-2H2	992,999	C-3	826,829	1,1-2H2	C-3	null	24232(Tax:10116)	Chemical	Gene	administration|nummod|START_ENTITY -LSB-|dobj|administration h|acl|-LSB- 2.7-4|nmod|h 2.7-4|nsubj|content content|nmod|C-2 C-2|conj|END_ENTITY	The total deuterium content at C-2 and C-3 of the glycerol moiety of 1-alkyl-2-acyl - _ and_1-alk-1 ' - enyl-2-acyl-sn-glycero-3-phosphocholines was 2.7-4 .4 atom % and 0.3-0 .8 atom % , respectively , after 48 h of -LSB- 1,1-2H2 -RSB- ethanol administration .
3988004	1	1,1,2-TCE	150,159	cytochrome_P-450	165,181	1,1,2-TCE	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital .
3988004	1	1,1,2-TCE	150,159	cytochrome_P-450	261,277	1,1,2-TCE	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	1,1,1-trichloroethane|conj|START_ENTITY interactions|nmod|1,1,1-trichloroethane observed|nsubjpass|interactions observed|xcomp|using using|xcomp|measure measure|dobj|changes changes|nmod|END_ENTITY	The real-time interactions of 1,1,1-trichloroethane -LRB- TCE -RRB- and 1,1,2-TCE with cytochrome_P-450 were observed using in vivo optical methods to measure the spectral changes of cytochrome_P-450 and the reduction-oxidation transition of pyridine_nucleotides in the perfused liver of rats treated with phenobarbital .
3988004	4	1,1,2-TCE	758,767	cytochrome_P-450	688,704	1,1,2-TCE	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	metabolized|advcl|START_ENTITY seemed|xcomp|metabolized bound|conj|seemed bound|nmod|END_ENTITY	However , 1,1,1-TCE bound more tightly to cytochrome_P-450 and seemed to be only slowly metabolized compared to 1,1,2-TCE .
3389679	2	1,1,2-TCE	759,768	GGT	895,898	1,1,2-TCE	GGT	null	116568(Tax:10116)	Chemical	Gene	1,1,2-trichloroethane|dep|START_ENTITY initiation|conj|1,1,2-trichloroethane administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY	When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels .
3389679	3	1,1,2-TCE	951,960	GGT	999,1002	1,1,2-TCE	GGT	null	116568(Tax:10116)	Chemical	Gene	1,1,2,2-TTCE|conj|START_ENTITY 1,1,2,2-TTCE|dep|increases increases|nmod|+ +|compound|END_ENTITY	1,1,2,2-TTCE , TTCY , and 1,1,2-TCE also induced significant increases in GGT + - foci when administered in the promotion protocol without DEN initiation .
4064948	1	1,1,2-trichloroethane	151,172	CD-1	194,198	1,1,2-trichloroethane	CD-1	MESH:C024567	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY assess|dobj|effects assess|nmod|mice mice|compound|END_ENTITY	The purpose of this study was to assess the immunological effects of 1,1,2-trichloroethane -LRB- TCE -RRB- on random-bred CD-1 mice following 14 and 90 days of oral exposure .
7285278	4	1,1,2-trichloroethane	755,776	cytochrome_P-450	706,722	1,1,2-trichloroethane	cytochrome P-450	MESH:C024567	4051	Chemical	Gene	metabolites|acl|START_ENTITY mono|nsubj|metabolites converted|advcl|mono converted|xcomp|2,2,2-trichloroethanol 2,2,2-trichloroethanol|nmod|END_ENTITY	1,1,1-trichloroethane is converted to 2,2,2-trichloroethanol by hepatic microsomal cytochrome_P-450 , while the major metabolites of 1,1,2-trichloroethane and 1,1,2,2-tetrachloroethane from this enzyme system are mono - _ and_dichloroacetate , respectively .
3389679	2	1,1,2-trichloroethane	736,757	GGT	895,898	1,1,2-trichloroethane	GGT	MESH:C024567	116568(Tax:10116)	Chemical	Gene	initiation|conj|START_ENTITY administered|advcl|initiation induced|advcl|administered induced|nmod|+ +|compound|END_ENTITY	When administered in the promotion protocol after initiation with DEN , 1,1-dichloroethane , 1,1,2-trichloroethane -LRB- 1,1,2-TCE -RRB- , 1,1,2,2-tetrachloroethane -LRB- 1,1,2,2-TTCE -RRB- , tetrachloroethylene -LRB- TTCY -RRB- , and hexachloroethane induced significant increases in GGT + - foci above control levels .
4064947	1	1,1,2-Trichloroethane	50,71	CD-1	114,118	1,1,2-Trichloroethane	CD-1	MESH:C024567	111334(Tax:10090)	Chemical	Gene	administered|nsubjpass|START_ENTITY administered|nmod|mice mice|compound|END_ENTITY	1,1,2-Trichloroethane -LRB- TCE -RRB- was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters .
19005803	2	1,1,2-trichlorotrifluoroethane	503,533	R12	494,497	1,1,2-trichlorotrifluoroethane	R12	null	2840	Chemical	Gene	trichlorofluoromethane|conj|START_ENTITY trichlorofluoromethane|conj|dichlorodifluoromethane dichlorodifluoromethane|dep|END_ENTITY	Fully halogenated VCCs -LRB- tetrachloroethylene , 1,1,1-trichloroethane , tetrachloromethane and dichloromethane -RRB- and CFCs -LRB- trichlorofluoromethane -LRB- R11 -RRB- , dichlorodifluoromethane -LRB- R12 -RRB- and 1,1,2-trichlorotrifluoroethane -LRB- R113 -RRB- -RRB- were degraded under anaerobic conditions in addition to the methanogenic bacteria in municipal solid waste -LRB- MSW -RRB- and organic wastes .
3016262	0	1,1,2-triphenylbut-1-ene	26,50	estradiol_receptor	89,107	1,1,2-triphenylbut-1-ene	estradiol receptor	MESH:C035804	13982(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY estrogens|nmod|type estrogens|dep|relationship relationship|nmod|structure structure|conj|affinity affinity|compound|END_ENTITY	Catechol estrogens of the 1,1,2-triphenylbut-1-ene type : relationship between structure , estradiol_receptor affinity , estrogenic and antiestrogenic properties , and mammary_tumor inhibiting activities .
6813499	0	1,1,2-triphenylbut-1-enes	0,25	estradiol_receptor	59,77	1,1,2-triphenylbut-1-enes	estradiol receptor	null	2099	Chemical	Gene	START_ENTITY|dep|relationship relationship|nmod|structure structure|conj|affinity affinity|compound|END_ENTITY	1,1,2-triphenylbut-1-enes : relationship between structure , estradiol_receptor affinity , and mammary_tumor inhibiting properties .
4068009	1	1,1,2-Triphenylbut-1-enes	107,132	Z-10-12	141,148	1,1,2-Triphenylbut-1-enes	Z-10-12	null	958016(Tax:155864)	Chemical	Gene	START_ENTITY|dep|- -|conj|END_ENTITY	1,1,2-Triphenylbut-1-enes -LRB- E - and Z-10-12 -RRB- , which are substituted with one p - and one m-acetoxy group in two different aromatic rings , were synthesized .
23186146	6	1,1,2-triphenylethane	1141,1162	Ph3E	1164,1168	1,1,2-triphenylethane	Ph3E	null	10338	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Formation of intramolecular dimer radical anions in Ph -LRB- n -RRB- E - such as 1,1,2-triphenylethane -LRB- Ph3E -RRB- , 1,1,1,2-tetraphenylethane -LRB- 1,1,1,2-Ph4E -RRB- , and 1,1,1,2,2-pentaphenylethane -LRB- Ph5E -RRB- was also studied together with the subsequent mesolysis .
17084061	0	1,1,2-Tris-organoselenide	0,25	delta-aminolevulinate_dehydratase	107,140	1,1,2-Tris-organoselenide	delta-aminolevulinate dehydratase	null	210	Chemical	Gene	derivatives|amod|START_ENTITY inhibited|nsubj|derivatives inhibited|dobj|activity activity|amod|END_ENTITY	1,1,2-Tris-organoselenide alkene derivatives , but not 1,2-bis-organoselenide alkene derivatives , inhibited delta-aminolevulinate_dehydratase activity from human erythrocytic cells in vitro .
1334553	6	11305-11309	543,554	Fc_gamma_RI	598,609	11305-11309	Fc gamma RI	MESH:C038213	2209	Chemical	Gene	USA|nummod|START_ENTITY -RSB-|dep|USA defined|dep|-RSB- defined|nmod|region region|nmod|gene gene|compound|END_ENTITY	USA 88 , 11305-11309 -RSB- defined within the promoter region of the Fc_gamma_RI gene an element , the gamma response region , which was necessary for IFN-gamma-induced enhancement of Fc_gamma_RI .
1334553	6	11305-11309	543,554	Fc_gamma_RI	711,722	11305-11309	Fc gamma RI	MESH:C038213	2209	Chemical	Gene	USA|nummod|START_ENTITY -RSB-|dep|USA defined|dep|-RSB- defined|nsubj|element element|appos|region region|acl:relcl|necessary necessary|nmod|enhancement enhancement|nmod|END_ENTITY	USA 88 , 11305-11309 -RSB- defined within the promoter region of the Fc_gamma_RI gene an element , the gamma response region , which was necessary for IFN-gamma-induced enhancement of Fc_gamma_RI .
21255402	9	11-32A	1317,1323	CC1690	1306,1312	11-32A	CC1690	null	942045(Tax:190650)	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Comparison of oil content in five common laboratory strains -LRB- CC124 , CC125 , cw15 , CC1690 and 11-32A -RRB- revealed a high variability , from 2 g TAG per million cell in CC124 to 11 g in 11-32A .
19631550	1	1,1,3,3-tetramethoxypropane	213,240	cis-4	250,255	1,1,3,3-tetramethoxypropane	cis-4	MESH:C041295	9306	Chemical	Gene	dimercapto-succinate|conj|START_ENTITY -2,3|amod|dimercapto-succinate transacetalation|nmod|-2,3 provided|nsubj|transacetalation provided|dobj|,5 ,5|amod|END_ENTITY	Acid-catalyzed transacetalation of dimethyl _ -LRB- 2R ,3 S -RRB- -2,3 - dimercapto-succinate and 1,1,3,3-tetramethoxypropane provided cis-4 ,5 - dimethoxycarbonyl-2 - -LRB- 2 ' ,2 ' - dimethoxyethyl -RRB- -1,3 - dithiolane -LRB- 2 -RRB- in 77 % yield .
12809941	3	1,1,3,3-tetramethyl-2-thiourea	530,560	IL-8	399,403	1,1,3,3-tetramethyl-2-thiourea	IL-8	null	3576	Chemical	Gene	N-acetyl-L-cysteine|conj|START_ENTITY antioxidants|amod|N-acetyl-L-cysteine effect|nmod|antioxidants evaluated|nsubjpass|effect determined|conj|evaluated determined|nsubjpass|induction induction|compound|END_ENTITY	IL-8 induction and secretion were determined in the presence of the toxics , and the effect of antioxidants N-acetyl-L-cysteine and 1,1,3,3-tetramethyl-2-thiourea was evaluated .
9668065	10	1,1,3,3-tetramethyl-2-thiourea	1809,1839	PAF-R	2076,2081	1,1,3,3-tetramethyl-2-thiourea	PAF-R	null	5724	Chemical	Gene	N-acetyl_cysteine|amod|START_ENTITY inhibited|nsubj|N-acetyl_cysteine inhibited|advcl|suggesting suggesting|ccomp|stimulates stimulates|nmod|activity activity|amod|END_ENTITY	The antioxidants N-acetyl_cysteine , 1,1,3,3-tetramethyl-2-thiourea , and vitamin_E inhibited both UVB-induced PAF biosynthesis as well as the augmentation of UVB-induced apoptosis in PAF-R-expressing KB clones , suggesting the possibility that UVB stimulates the production of oxidized lipid species with PAF-R agonistic activity in this model system .
19277394	1	1,1,3,3-tetramethyldisiloxane	173,202	PPh3	161,165	1,1,3,3-tetramethyldisiloxane	PPh3	null	857	Chemical	Gene	2|nmod|START_ENTITY IrCl|dep|2 IrCl|appos|END_ENTITY	The combination of IrCl -LRB- CO -RRB- -LRB- PPh3 -RRB- 2 with 1,1,3,3-tetramethyldisiloxane or poly -LRB- methylhydrosiloxane -RRB- -LRB- PMHS -RRB- is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides ; in particular , facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS .
24768890	4	1,1,3,3-tetramethylguanidine	485,513	CO2	705,708	1,1,3,3-tetramethylguanidine	CO2	MESH:C477069	717	Chemical	Gene	START_ENTITY|acl|based based|ccomp|synthesized synthesized|nmod|tetrafluoroborate tetrafluoroborate|dep|used used|nmod|absorption absorption|nmod|SO2 SO2|conj|END_ENTITY	1,1,3,3-tetramethylguanidine -LRB- TMG -RRB- - based ILs , including 1,1,3,3-tetramethylguanidine tetrafluoroborate -LRB- -LSB- TMG -RSB- -LSB- BF4 -RSB- -RRB- and 1,1,3,3-tetramethylguanidine _ lactate -LRB- -LSB- TMG -RSB- L -RRB- which were commonly used in the absorption of SO2 and CO2 from flue gas , were synthesized and applied in the conversion of MCC to 5-HMF for the first time .
24768890	4	1,1,3,3-tetramethylguanidine	541,569	CO2	705,708	1,1,3,3-tetramethylguanidine	CO2	MESH:C477069	717	Chemical	Gene	tetrafluoroborate|amod|START_ENTITY tetrafluoroborate|dep|used used|nmod|absorption absorption|nmod|SO2 SO2|conj|END_ENTITY	1,1,3,3-tetramethylguanidine -LRB- TMG -RRB- - based ILs , including 1,1,3,3-tetramethylguanidine tetrafluoroborate -LRB- -LSB- TMG -RSB- -LSB- BF4 -RSB- -RRB- and 1,1,3,3-tetramethylguanidine _ lactate -LRB- -LSB- TMG -RSB- L -RRB- which were commonly used in the absorption of SO2 and CO2 from flue gas , were synthesized and applied in the conversion of MCC to 5-HMF for the first time .
28464505	2	1,1,3,3-tetramethylguanidine	487,515	CO2	349,352	1,1,3,3-tetramethylguanidine	CO2	MESH:C477069	717	Chemical	Gene	Ag2O/TMG|dep|START_ENTITY promoted|nmod|Ag2O/TMG a-hydroxyl_ketones|acl|promoted amount|nmod|a-hydroxyl_ketones synthesis|nmod|amount developed|nmod|synthesis END_ENTITY|conj|developed	Herein , a one-pot three-component reaction of terminal propargyl_alcohols , CO2 , and 2-aminoethanols was developed for the synthesis of 2-oxazolidinones and equal amount of a-hydroxyl_ketones promoted by Ag2O/TMG -LRB- 1,1,3,3-tetramethylguanidine -RRB- with the TON -LRB- turnover number -RRB- up to 1260 .
21619462	3	11365C	572,578	ADIPOQ	541,547	11365C	ADIPOQ	null	9370	Chemical	Gene	G|nummod|START_ENTITY rs266729|appos|G rs2241766|nsubj|rs266729 rs2241766|dep|Genotyping Genotyping|nmod|SNPs SNPs|nmod|gene gene|amod|END_ENTITY	Genotyping of SNPs in the ADIPOQ gene , namely , rs266729 -LRB- 11365C > G -RRB- ; rs822395 -LRB- 4034A > C -RRB- ; rs822396 -LRB- 3964A > G -RRB- ; rs2241766 -LRB- +45 T > G -RRB- were performed .
9266215	1	1-13C	98,103	galactose-1-phosphate_uridyltransferase	212,251	1-13C	galactose-1-phosphate uridyltransferase	null	2592	Chemical	Gene	-RSB-|nummod|START_ENTITY _|nmod:npmod|-RSB- galactose|amod|_ employed|dobj|galactose employed|advcl|delineate delineate|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	We employed -LSB- 1-13C -RSB- _ galactose in isotope kinetic studies to delineate whole body galactose metabolism in vivo in patients with galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- deficiency .
9266215	1	1-13C	98,103	GALT	253,257	1-13C	GALT	null	2592	Chemical	Gene	-RSB-|nummod|START_ENTITY _|nmod:npmod|-RSB- galactose|amod|_ employed|dobj|galactose employed|advcl|delineate delineate|nmod|patients patients|nmod|deficiency deficiency|appos|END_ENTITY	We employed -LSB- 1-13C -RSB- _ galactose in isotope kinetic studies to delineate whole body galactose metabolism in vivo in patients with galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- deficiency .
9266222	8	1-13C_butyric_and_1-13C_octanoic_acids	1151,1189	MADM	1120,1124	1-13C butyric and 1-13C octanoic acids	MADM	null	29959	Chemical	Gene	oxidation|nmod|START_ENTITY normal|nsubj|oxidation normal|nmod|patient patient|compound|END_ENTITY	In the MADM patient , the oxidation of 1-13C_butyric_and_1-13C_octanoic_acids were normal , whereas the metabolism of 1-13C_palmitic_acid ranged from 33 % of 66 % of controls .
8683583	10	113Cd	1234,1239	CYP1	1326,1330	113Cd	CYP1	CHEBI:52620	850958(Tax:4932)	Chemical	Gene	spectroscopy|amod|START_ENTITY 1H|conj|spectroscopy Using|dobj|1H undertaken|advcl|Using undertaken|dobj|analysis analysis|nmod|properties properties|nmod|fragment fragment|compound|END_ENTITY	Using 1H , 15N and 113Cd NMR spectroscopy , we have undertaken the analysis of the structural properties of the CYP1 -LRB- 56-126 -RRB- fragment that consists of the zinc-cluster region , the linker peptide and a part of the dimerization helix .
2186803	5	113Cd	564,569	GAL4	715,719	113Cd	GAL4	CHEBI:52620	855828(Tax:4932)	Chemical	Gene	NMR|compound|START_ENTITY NMR|dep|GAL4 GAL4|acl:relcl|reveals reveals|dobj|identity identity|nmod|domains domains|nmod|GAL4 GAL4|conj|that that|nmod|END_ENTITY	113Cd NMR of 113Cd -LRB- II -RRB- - substituted GAL4 -LRB- 63 -RRB- reveals structural identity between the metal binding domains of GAL4 -LRB- 63 -RRB- and that of the larger precursor GAL4 -LRB- 149 -RRB- .
2186803	5	113Cd	577,582	GAL4	715,719	113Cd	GAL4	CHEBI:52620	855828(Tax:4932)	Chemical	Gene	NMR|nmod|START_ENTITY NMR|dep|GAL4 GAL4|acl:relcl|reveals reveals|dobj|identity identity|nmod|domains domains|nmod|GAL4 GAL4|conj|that that|nmod|END_ENTITY	113Cd NMR of 113Cd -LRB- II -RRB- - substituted GAL4 -LRB- 63 -RRB- reveals structural identity between the metal binding domains of GAL4 -LRB- 63 -RRB- and that of the larger precursor GAL4 -LRB- 149 -RRB- .
1936288	1	113Cd	230,235	glucocorticoid_receptor	278,301	113Cd	glucocorticoid receptor	CHEBI:52620	24413(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Two-dimensional 1H-113Cd HSQC and relay HSQC experiments were performed on the 113Cd substituted DNA binding domain of the rat glucocorticoid_receptor .
437098	0	113Cd	49,54	Mg2	0,3	113Cd	Mg2	CHEBI:52620	4589	Chemical	Gene	25Mg|conj|START_ENTITY spectroscopy|compound|25Mg studied|nmod|spectroscopy parvalbumins|acl|studied binding|nmod|parvalbumins +|xcomp|binding +|nsubj|END_ENTITY	Mg2 + binding to parvalbumins studied by 25Mg and 113Cd NMR spectroscopy .
7056717	11	113Cd	1500,1505	MT-1	1533,1537	113Cd	MT-1	CHEBI:52620	539948(Tax:9913)	Chemical	Gene	spectrum|amod|START_ENTITY spectrum|nmod|END_ENTITY	Three minor resonances to higher field are observed in the 113Cd NMR spectrum of calf liver MT-1 and one in calf liver MT-2 , which may be attributed to a small fraction of cluster B with one Cu + replaced by 113Cd2 + .
3681973	4	113Cd	944,949	MT2	954,957	113Cd	MT2	CHEBI:52620	689415(Tax:10116)	Chemical	Gene	preparations|nmod|START_ENTITY homogeneous|dobj|preparations homogeneous|parataxis|obtained obtained|nsubjpass|END_ENTITY	Solutions of high-pressure liquid chromatographically homogeneous biosynthetic preparations of -LSB- 113Cd , Zn -RSB- MT2 were obtained from rat liver following injection of 113Cd into rats in vivo , without further metal exchange after protein isolation .
7056717	11	113Cd	1500,1505	MT-2	1560,1564	113Cd	MT-2	CHEBI:52620	404070(Tax:9913)	Chemical	Gene	spectrum|amod|START_ENTITY observed|nmod|spectrum observed|nmod|END_ENTITY	Three minor resonances to higher field are observed in the 113Cd NMR spectrum of calf liver MT-1 and one in calf liver MT-2 , which may be attributed to a small fraction of cluster B with one Cu + replaced by 113Cd2 + .
8387280	0	113Cd-1H	14,22	retinoic_acid_receptor-beta	68,95	113Cd-1H	retinoic acid receptor-beta	null	5915	Chemical	Gene	study|amod|START_ENTITY study|nmod|coordination coordination|nmod|domain domain|compound|END_ENTITY	Heteronuclear 113Cd-1H NMR study of metal coordination in the human retinoic_acid_receptor-beta DNA binding domain .
3681973	6	113Cd7	1437,1443	MT2	1444,1447	113Cd7	MT2	null	689415(Tax:10116)	Chemical	Gene	END_ENTITY|compound|START_ENTITY	For the components of the four-metal cluster , the major one of these different forms exhibits patterns in the two-dimensional -LSB- 1H , _ 113Cd -RSB- - correlated spectra that are indistinguishable from those of -LSB- 113Cd7 -RSB- MT2 , thereby implying identity of cluster coordination and topology .
9256239	2	113Cd-substituted_HDH	274,295	Cd2	322,325	113Cd-substituted HDH	Cd2	null	914	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	113Cd-substituted_HDH in the presence of excess Cd2 + has been studied by 113Cd-NMR .
1657733	6	1-13C-ethanol	1128,1141	spin	1042,1046	1-13C-ethanol	spin	null	361217(Tax:10116)	Chemical	Gene	adduct|amod|START_ENTITY those|nmod|adduct lines|nmod|those indicated|nmod|lines adduct|acl:relcl|indicated adduct|compound|END_ENTITY	Liver extracts also contained low concentrations of the 1-hydroxyethyl radical spin adduct , which was indicated by weak spectral lines corresponding to those of the 1-13C-ethanol adduct .
8960831	4	1-13C-glucose	964,977	insulin	1038,1045	1-13C-glucose	insulin	null	3630	Chemical	Gene	clamp|nmod|START_ENTITY quantitate|nsubj|clamp quantitate|dobj|action action|compound|END_ENTITY	The euglycaemic hyperinsulinaemic clamp with 1-13C-glucose -LRB- Hot Ginf -RRB- and indirect calorimetry were used to quantitate insulin action and the hyperglycaemic clamp used to assess beta-cell function .
9266217	5	1-13C_leucine	642,655	CO2	757,760	1-13C leucine	CO2	null	717	Chemical	Gene	technique|amod|START_ENTITY model|nsubj|technique model|acl|requiring requiring|dobj|estimation estimation|nmod|production production|compound|END_ENTITY	The 1-13C_leucine technique is the most widely used and best validated model to date , requiring accurate estimation of CO2 production .
1690064	0	1-13C-leucine	34,47	apolipoprotein_B	51,67	1-13C-leucine	apolipoprotein B	null	338	Chemical	Gene	15N-glycine|conj|START_ENTITY Incorporation|acl|15N-glycine Incorporation|nmod|END_ENTITY	-LSB- Incorporation of 15N-glycine and 1-13C-leucine in apolipoprotein_B of VLDL and LDL in vivo in healthy probands -RSB- .
1430077	12	1-13C-leucine	1163,1176	IGF-I	1232,1237	1-13C-leucine	IGF-I	null	3479	Chemical	Gene	technique|amod|START_ENTITY flux|appos|technique decreased|nsubj|flux decreased|nmod|doses doses|nmod|END_ENTITY	Whole body leucine flux -LRB- 1-13C-leucine infusion technique -RRB- decreased with increasing doses of IGF-I by 41 % during 30 micrograms/kg .
21429235	4	113C-Leucine	620,632	surfactant_protein-B	649,669	113C-Leucine	surfactant protein-B	null	6439	Chemical	Gene	disaturated-phosphatidylcholine-palmitate|conj|START_ENTITY disaturated-phosphatidylcholine-palmitate|dep|administered administered|nsubjpass|precursor precursor|nmod|END_ENTITY	METHODS : 2H2O as precursor of disaturated-phosphatidylcholine-palmitate and 113C-Leucine as precursor of surfactant_protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls .
18543754	2	1-13-corticotropine	233,252	alpha-MSH	368,377	1-13-corticotropine	alpha-MSH	null	24664(Tax:10116)	Chemical	Gene	components|amod|START_ENTITY consists|nmod|components called|ccomp|consists called|nsubj|effects effects|amod|Met-enkephalin Met-enkephalin|conj|END_ENTITY	It consists of two peptide components : met-enkephalin and alpha 1-13-corticotropine -LRB- alpha-ACTH 1-13 -RRB- , previously called alpha-melanocyte-stimulating hormone-like -LRB- alpha-MSH-like -RRB- Met-enkephalin and alpha-MSH exhibited cytoprotective effects individually and statistically significant additive effect was registered when both peptides were applied in combination on the model of ethanol induced gastric_lesions in rats .
9266222	6	1-13C_palmitic_acid	926,945	MADM	839,843	1-13C palmitic acid	MADM	null	29959	Chemical	Gene	utilization|nmod|START_ENTITY therapy|nmod|utilization influence|nmod|therapy examined|nsubjpass|influence examined|nmod|patient patient|compound|END_ENTITY	In the MADM patient the influence of carnitine therapy -LRB- or deprivation -RRB- on the utilization of 1-13C_palmitic_acid was also examined .
9266222	8	1-13C_palmitic_acid	1229,1248	MADM	1120,1124	1-13C palmitic acid	MADM	null	29959	Chemical	Gene	metabolism|nmod|START_ENTITY ranged|nsubj|metabolism normal|advcl|ranged normal|nmod|patient patient|compound|END_ENTITY	In the MADM patient , the oxidation of 1-13C_butyric_and_1-13C_octanoic_acids were normal , whereas the metabolism of 1-13C_palmitic_acid ranged from 33 % of 66 % of controls .
11597790	2	113His	435,441	EPHX1	384,389	113His	EPHX1	null	2052	Chemical	Gene	113Tyr|dep|START_ENTITY region|conj|113Tyr region|nmod|gene gene|appos|END_ENTITY	Two polymorphisms have been described in the coding region of the mEH gene -LRB- EPHX1 -RRB- that produce two protein variants : 113Tyr -- > 113His -LRB- exon 3 -RRB- and 139His -- > 139Arg -LRB- exon 4 -RRB- .
11597790	2	113His	435,441	mEH	374,377	113His	mEH	null	13849(Tax:10090)	Chemical	Gene	113Tyr|dep|START_ENTITY region|conj|113Tyr region|nmod|gene gene|compound|END_ENTITY	Two polymorphisms have been described in the coding region of the mEH gene -LRB- EPHX1 -RRB- that produce two protein variants : 113Tyr -- > 113His -LRB- exon 3 -RRB- and 139His -- > 139Arg -LRB- exon 4 -RRB- .
7430349	9	113In	837,842	transferrin	843,854	113In	transferrin	null	7018	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Plasma clearance of -LSB- 113In -RSB- transferrin occurred with a T1/2 = 7.0 + / - 2.6 h -LRB- mean + / - SD -RRB- .
2668738	2	113-kilodalton	319,333	KEX1	380,384	113-kilodalton	KEX1	MESH:C083025	852670(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY protein|acl:relcl|absent absent|dep|disrupted disrupted|nsubjpass|gene gene|compound|END_ENTITY	Anti-Kex1p antibodies identified a 113-kilodalton protein that was absent in cells in which the KEX1 gene has been disrupted and that was more abundant in cells overexpressing the KEX1 gene .
2298374	7	113mIn	1109,1115	transferrin	1117,1128	113mIn	transferrin	null	100009267(Tax:9986)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Uncorrected or simple brain uptake indices of -LSB- 3H -RSB- _ gamma-aminobutyric_acid and -LSB- 113mIn -RSB- transferrin were calculated using -LSB- 14C -RSB- _ butanol as the highly extracted reference compound .
11108834	1	1-13_nucleotides	292,308	DNA_polymerase_delta	136,156	1-13 nucleotides	DNA polymerase delta	MESH:D009711	5424	Chemical	Gene	gaps|nmod|START_ENTITY containing|dobj|gaps duplexes|acl|containing Misgurnus|nmod|duplexes Misgurnus|nsubj|interaction interaction|nmod|END_ENTITY	We studied the interaction of DNA_polymerase_delta -LRB- pol delta -RRB- purified from the eggs of the teleost fish Misgurnus fossilis -LRB- loach -RRB- with DNA duplexes containing single-stranded gaps of 1-13_nucleotides -LRB- nt -RRB- .
625587	1	1,1,3-tricyano-2-amino-1-propene	117,149	CNP	266,269	1,1,3-tricyano-2-amino-1-propene	CNP	MESH:C025201	395921(Tax:9031)	Chemical	Gene	Injections|nmod|START_ENTITY increases|nsubj|Injections increases|ccomp|enzyme enzyme|dobj|phosphohydrolase phosphohydrolase|appos|END_ENTITY	Injections of 1,1,3-tricyano-2-amino-1-propene -LRB- TCAP -RRB- into chick embryos increases the synthesis of the myelin enzyme 2 ' ,3 ' - cyclic nucleotide 3 ' - phosphohydrolase -LRB- CNP -RRB- .
20534649	5	1-140	1045,1050	alpha-synuclein	1029,1044	1-140	alpha-synuclein	MESH:C065679	6622	Chemical	Gene	END_ENTITY|appos|START_ENTITY	Furthermore , the release of FM1-43 dye from PC12 cells expressing either human full-length alpha-synuclein -LRB- 1-140 -RRB- or truncated alpha-synuclein -LRB- 1-120 -RRB- was reduced .
20534649	5	1-140	1045,1050	alpha-synuclein	1065,1080	1-140	alpha-synuclein	MESH:C065679	20617(Tax:10090)	Chemical	Gene	alpha-synuclein|appos|START_ENTITY END_ENTITY|conj|alpha-synuclein	Furthermore , the release of FM1-43 dye from PC12 cells expressing either human full-length alpha-synuclein -LRB- 1-140 -RRB- or truncated alpha-synuclein -LRB- 1-120 -RRB- was reduced .
17002294	4	1-140	865,870	MDM2	837,841	1-140	MDM2	MESH:C065679	4193	Chemical	Gene	31|appos|START_ENTITY 31|amod|peptides peptides|nmod|END_ENTITY	The affinities of the chimeric peptides to MDM2 -LRB- 25-117 -RRB- and hTAF -LRB- II -RRB- 31 -LRB- 1-140 -RRB- were determined .
17426819	1	114-166_glycopeptide	172,192	erythropoietin	237,251	114-166 glycopeptide	erythropoietin	MESH:D006020	2056	Chemical	Gene	EPO|nummod|START_ENTITY synthesis|nmod|EPO described|nsubjpass|synthesis described|advcl|presenting presenting|dobj|glycophorin glycophorin|nmod|END_ENTITY	A synthesis of EPO 114-166_glycopeptide -LRB- 1 -RRB- , presenting the O-linked glycophorin of erythropoietin , is described .
7782288	3	1141_amino_acid	680,695	cGI-PDE	671,678	1141 amino acid	cGI-PDE	null	5139	Chemical	Gene	END_ENTITY|appos|START_ENTITY	The nucleotide sequence of its open reading frame was virtually identical to a corresponding region in the 3 ' portion of the cardiac cGIP2 cDNA -LRB- approximately 7.6 kb -RRB- which encoded a approximately 125-kDa cGI-PDE -LRB- 1141_amino_acid -RRB- .
12462625	5	1141-SO3H	748,757	MS3	706,709	1141-SO3H	MS3	null	100271695	Chemical	Gene	-RSB-|nummod|START_ENTITY gave|dobj|-RSB- gave|nsubj|MS-MS MS-MS|conj|END_ENTITY	MS-MS and MS3 gave major fragment ions at m/z 1061 -LSB- 1141-SO3H -RSB- - and m/z 945 -LSB- 1061-C9H12O -RSB- - .
9131949	1	114297A	185,192	beta_2-adrenoceptor	153,172	114297A	beta 2-adrenoceptor	null	154	Chemical	Gene	GR|nummod|START_ENTITY R-enantiomer|nsubj|GR agonist|dep|R-enantiomer agonist|amod|END_ENTITY	AIMS : The new potent and selective beta_2-adrenoceptor agonist , GR 114297A -LRB- picumeterol -RRB- is the R-enantiomer of the racemic form , GR_63411B .
20688124	8	1,1,4,4-TetraCBD	1358,1374	HPRT	1476,1480	1,1,4,4-TetraCBD	HPRT	null	3251	Chemical	Gene	recommended|nmod|START_ENTITY recommended|xcomp|perform perform|dobj|test test|appos|test test|amod|END_ENTITY	For the main component 1,1,4,4-TetraCBD , which is negative in the Ames , it is recommended to perform a third in vitro genotoxicity test , the HPRT test , before it can be decided whether to refer to the guideline value of HexaCBD at 600 ng/L or still to use the conservative TTC-based target value of 75 ng/L .
11283007	1	1145-amino_acid_DEXH	116,136	PRP22	95,100	1145-amino acid DEXH	PRP22	MESH:C456319	856732(Tax:4932)	Chemical	Gene	helicase|amod|START_ENTITY encodes|dobj|helicase encodes|nsubj|gene gene|compound|END_ENTITY	The essential Saccharomyces_cerevisiae PRP22 gene encodes a 1145-amino_acid_DEXH box RNA helicase .
19825998	5	1-146	776,781	apoA-V	769,775	1-146	apoA-V	MESH:D051929	116519	Chemical	Gene	segments|appos|START_ENTITY segments|amod|END_ENTITY	Fourier transformed infrared spectroscopy analysis revealed that apoA-V -LRB- 1-146 -RRB- alpha-helix segments align perpendicular with respect to particle phospholipid fatty acyl chains .
19825998	7	1-146	1071,1076	apoA-V	1064,1070	1-146	apoA-V	MESH:D051929	116519	Chemical	Gene	alpha-helices|appos|START_ENTITY alpha-helices|amod|END_ENTITY	The data are consistent with a model wherein apoA-V -LRB- 1-146 -RRB- alpha-helices circumscribe the perimeter of a disk-shaped bilayer .
21335450	0	11478G	9,15	SERPINA1	0,8	11478G	SERPINA1	MESH:C420352	5265	Chemical	Gene	START_ENTITY|compound|END_ENTITY	SERPINA1 11478G _ > _ A variant , serum a1-antitrypsin , exacerbation frequency and FEV1 decline in COPD .
21193293	3	11482G	630,636	insulin	657,664	11482G	insulin	MESH:C420352	3630	Chemical	Gene	PLIN1|nummod|START_ENTITY interaction|nmod|PLIN1 __|nsubj|interaction __|dobj|A A|nmod|resistance resistance|compound|END_ENTITY	METHODS AND RESULTS : We investigated the previously shown interaction for PLIN1 11482G __ > __ A -LRB- rs894160 -RRB- on insulin resistance in US men -LRB- n = 462 -RRB- and women -LRB- n = 508 -RRB- -LRB- mean SD , 49 16 years -RRB- .
21193293	4	11482G	927,933	insulin	985,992	11482G	insulin	MESH:C420352	3630	Chemical	Gene	intake|conj|START_ENTITY carbohydrate|dobj|intake carbohydrate|nmod|HOMA-IR HOMA-IR|dep|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	In multivariable linear regression models , we found an interaction -LRB- P < 0.05 -RRB- between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN1 11482G __ > __ A for HOMA-IR -LRB- homeostasis model assessment of insulin resistance -RRB- in women .
15770500	2	11482G	378,384	perilipin	330,339	11482G	perilipin	MESH:C420352	5346	Chemical	Gene	A|nummod|START_ENTITY T|conj|A locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
18326614	2	11482G	416,422	perilipin	367,376	11482G	perilipin	MESH:C420352	5346	Chemical	Gene	PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|compound|END_ENTITY	OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations .
15770500	2	11482G	378,384	PLIN	341,345	11482G	PLIN	MESH:C420352	5346	Chemical	Gene	A|nummod|START_ENTITY T|conj|A locus|dep|T locus|nsubj|polymorphisms polymorphisms|nmod|perilipin perilipin|appos|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
15770500	2	11482G	378,384	PLIN	354,358	11482G	PLIN	MESH:C420352	5346	Chemical	Gene	A|nummod|START_ENTITY T|conj|A T|compound|END_ENTITY	We examined five common single nucleotide polymorphisms -LRB- SNPs -RRB- at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN 6209C > T , 10171A > T , 11482G > A , 13041A > G , and 14995A > T -RRB- to investigate their association with obesity risk .
18326614	2	11482G	416,422	PLIN	378,382	11482G	PLIN	MESH:C420352	5346	Chemical	Gene	PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|appos|END_ENTITY	OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations .
18326614	2	11482G	416,422	PLIN1	391,396	11482G	PLIN1	MESH:C420352	5346	Chemical	Gene	PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|nmod|locus locus|dep|END_ENTITY	OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations .
21193293	3	11482G	630,636	PLIN1	624,629	11482G	PLIN1	MESH:C420352	5346	Chemical	Gene	END_ENTITY|nummod|START_ENTITY	METHODS AND RESULTS : We investigated the previously shown interaction for PLIN1 11482G __ > __ A -LRB- rs894160 -RRB- on insulin resistance in US men -LRB- n = 462 -RRB- and women -LRB- n = 508 -RRB- -LRB- mean SD , 49 16 years -RRB- .
21193293	4	11482G	927,933	PLIN1	921,926	11482G	PLIN1	MESH:C420352	5346	Chemical	Gene	START_ENTITY|compound|END_ENTITY	In multivariable linear regression models , we found an interaction -LRB- P < 0.05 -RRB- between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN1 11482G __ > __ A for HOMA-IR -LRB- homeostasis model assessment of insulin resistance -RRB- in women .
18326614	2	11482G	416,422	PLIN4	409,414	11482G	PLIN4	MESH:C420352	729359	Chemical	Gene	END_ENTITY|amod|START_ENTITY	OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations .
18326614	2	11482G	416,422	PLIN5	428,433	11482G	PLIN5	MESH:C420352	440503	Chemical	Gene	PLIN4|amod|START_ENTITY polymorphisms|conj|PLIN4 polymorphisms|conj|END_ENTITY	OBJECTIVE : We aimed to examine whether the presence of polymorphisms at the perilipin -LRB- PLIN -RRB- locus -LRB- PLIN1 , 6209T -- > C ; PLIN4 , 11482G -- > A ; PLIN5 , 13041A -- > G ; and PLIN6 , 14995A -- > T -RRB- influence postprandial lipoprotein metabolism in 2 white populations .
23649624	1	114-amino_acid	152,166	IL-15	142,147	114-amino acid	IL-15	MESH:C087595	3600	Chemical	Gene	cytokine|amod|START_ENTITY Interleukin-15|appos|cytokine Interleukin-15|appos|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets .
23649624	1	114-amino_acid	152,166	IL-2	187,191	114-amino acid	IL-2	MESH:C087595	3558	Chemical	Gene	cytokine|amod|START_ENTITY cytokine|acl|related related|nmod|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets .
23649624	1	114-amino_acid	152,166	Interleukin-15	126,140	114-amino acid	Interleukin-15	MESH:C087595	3600	Chemical	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Interleukin-15 -LRB- IL-15 -RRB- , a 114-amino_acid cytokine related to IL-2 , regulates immune homeostasis and the fate of many lymphocyte subsets .
8622698	5	114-amino-acid	882,896	CBF1	844,848	114-amino-acid	CBF1	null	19664(Tax:10090)	Chemical	Gene	region|amod|START_ENTITY contains|nsubj|region demonstrated|ccomp|contains demonstrated|nsubj|assays assays|acl|using using|dobj|segments segments|nmod|NotchIC NotchIC|conj|END_ENTITY	Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction .
8622698	5	114-amino-acid	882,896	CBF1	934,938	114-amino-acid	CBF1	null	19664(Tax:10090)	Chemical	Gene	region|amod|START_ENTITY contains|nsubj|region contains|dobj|domain domain|compound|END_ENTITY	Cotransfection assays using segments of mouse NotchIC and CBF1 demonstrated that the N-terminal 114-amino-acid region of mouse NotchIC contains the CBF1 interactive domain and that the cdc10/ankyrin repeats are not essential for this interaction .
8622698	6	114-amino-acid	1111,1125	CBF1	1201,1205	114-amino-acid	CBF1	null	3516	Chemical	Gene	segment|amod|START_ENTITY coprecipitated|nsubj|segment coprecipitated|nmod|END_ENTITY	This result was confirmed in immunoprecipation assays in which the N-terminal 114-amino-acid segment of NotchIC , but not the ankyrin repeat region , coprecipitated with CBF1 .
9418891	8	114-amino-acid	1102,1116	COX7RP	1181,1187	114-amino-acid	COX7RP	null	9167	Chemical	Gene	protein|amod|START_ENTITY similar|nsubj|protein similar|nmod|VIIa VIIa|appos|END_ENTITY	The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- .
9418891	8	114-amino-acid	1102,1116	cytochrome_c_oxidase_subunit_VII-related_protein	1189,1237	114-amino-acid	cytochrome c oxidase subunit VII-related protein	null	9167	Chemical	Gene	protein|amod|START_ENTITY similar|nsubj|protein similar|nmod|VIIa VIIa|appos|COX7RP COX7RP|appos|END_ENTITY	The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- .
9418891	8	114-amino-acid	1102,1116	EB1	1088,1091	114-amino-acid	EB1	null	9167	Chemical	Gene	protein|amod|START_ENTITY similar|nsubj|protein encodes|xcomp|similar encodes|nsubj|cDNA cDNA|acl|associated associated|nmod|END_ENTITY	The cDNA associated with EB1 encodes a 114-amino-acid protein similar to the cytochrome c oxidase subunit VIIa , named COX7RP -LRB- cytochrome_c_oxidase_subunit_VII-related_protein -RRB- .
7884911	5	114-amino-acid	793,807	SP1	822,825	114-amino-acid	SP1	null	6667	Chemical	Gene	region|amod|START_ENTITY region|nmod|domain domain|compound|END_ENTITY	We delineate a 114-amino-acid region of the SP1 glutamine-rich activation domain that when fused to the GAL4 DNA binding domain can support transcription activation by Tat .
2344442	8	1-14C	791,796	CO2	858,861	1-14C	CO2	null	717	Chemical	Gene	%|nmod|START_ENTITY Less|nmod|% recovered|nsubjpass|Less recovered|nmod|END_ENTITY	Less than 1 % of the 1-14C from the dodecylthioacetic_acid was recovered in respiratory CO2 and about 3 % of the 1-14C from nonylthioacetic_acid .
8633856	8	1-14C	1220,1225	CO2	1203,1206	1-14C	CO2	null	717	Chemical	Gene	glucose|nummod|START_ENTITY -LSB-|dobj|glucose formed|advcl|-LSB- END_ENTITY|acl|formed	The amount of CO2 formed from -LSB- 1-14C -RSB- glucose and acetate labeling patterns obtained with the other 14C precursors indicated that the Entner-Doudoroff , transketolase-transaldolase , and heterolactic pathways were not significant .
8998370	11	1-14C	1800,1805	delta_9_and_delta_5_desaturase	1944,1974	1-14C	delta 9 and delta 5 desaturase	null	3995;3992	Chemical	Gene	-RSB-|compound|START_ENTITY Conversion|nmod|-RSB- inhibited|nsubjpass|Conversion inhibited|nmod|ethanol ethanol|acl|treated treated|xcomp|suggesting suggesting|dobj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Conversion of -LSB- 1-14C -RSB- palmitic to oleic_acid and eicosatrienoic to arachidonic_acid were inhibited in 400 mM ethanol treated cells suggesting an inhibition of delta_9_and_delta_5_desaturase activity .
8330014	6	1-14C	1047,1052	glucose-6-phosphate_dehydrogenase	944,977	1-14C	glucose-6-phosphate dehydrogenase	null	2539	Chemical	Gene	glucose|nummod|START_ENTITY oxidation|nmod|glucose glycogen|conj|oxidation glycogen|conj|activities activities|nmod|dehydrogenase dehydrogenase|amod|END_ENTITY	These observations are consistent with the significantly lower content of glycogen , the increased activities of glucose-6-phosphate_dehydrogenase and 6-phosphogluconate dehydrogenase and the increased oxidation of -LSB- 1-14C -RSB- glucose relative to -LSB- 6-14C -RSB- _ glucose in the differentiated cells .
8650256	5	1-14C	741,746	PLA-2	721,726	1-14C	PLA-2	null	5320	Chemical	Gene	oleic_acid|nummod|START_ENTITY END_ENTITY|nmod|oleic_acid	We report here data that demonstrates how various cytokines exhibit a marked hydrolytic activity mediated through PLA-2 against both -LSB- 1-14C -RSB- oleic_acid - and -LSB- 1-14C -RSB- arachidonic_acid-labeled Escherichia_coli -LRB- micelle -RRB- substrates .
712202	2	1-14C-AA	542,550	CO2	460,463	1-14C-AA	CO2	null	717	Chemical	Gene	incubated|nmod|START_ENTITY incubated|nmod|C C|dep|buffer buffer|appos|END_ENTITY	Slices of rabbit and human renal_papilla were incubated in Krebs-Ringer HCO3 - buffer , 95 % O2-5 % CO2 , glucose 10 mM , HSA 4 gm/100 ml , for 30 min at 38 degrees C , with and without 1-14C-AA -LRB- 10 micrometer -RRB- .
8480350	8	1-14C_acetate	1149,1162	CO2	1300,1303	1-14C acetate	CO2	null	717	Chemical	Gene	START_ENTITY|acl:relcl|suggests suggests|ccomp|reflected reflected|nmod|END_ENTITY	There was no disappearance of tritiated_acetate from PCs or of 1-14C_acetate from platelet-free mixtures of plasma and Seto_sol , which suggests that the disappearance of 14C_acetate from PCs reflected oxidation to CO2 , which could leave PCs through the walls of the plastic container .
1904726	3	1-14C-acetate	576,589	C-1	539,542	1-14C-acetate	C-1	null	3183	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Because the oxidation of pyruvate labelled in position C-1 but not of 2-14C-pyruvate and of 1-14C-acetate was enhanced , captopril most probably stimulated the pyruvate decarboxylation reaction .
9822550	11	1-14C-acetyl	1662,1674	COX-2	1642,1647	1-14C-acetyl	COX-2	null	19225(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY reacted|nmod|-RSB- END_ENTITY|acl|reacted	Tryptic digestion and peptide mapping of COX-2 reacted with -LSB- 1-14C-acetyl -RSB- -36 indicated that selective COX-2 inhibition by 36 also resulted in the acetylation of Ser516 .
9822550	11	1-14C-acetyl	1662,1674	COX-2	1704,1709	1-14C-acetyl	COX-2	null	19225(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY reacted|nmod|-RSB- COX-2|acl|reacted digestion|nmod|COX-2 indicated|nsubj|digestion indicated|ccomp|resulted resulted|nsubj|inhibition inhibition|compound|END_ENTITY	Tryptic digestion and peptide mapping of COX-2 reacted with -LSB- 1-14C-acetyl -RSB- -36 indicated that selective COX-2 inhibition by 36 also resulted in the acetylation of Ser516 .
6424180	1	1-14C-arachidonate	283,301	lipoxygenase	157,169	1-14C-arachidonate	lipoxygenase	null	100009114(Tax:9986)	Chemical	Gene	homogenates|amod|START_ENTITY incubations|nmod|homogenates derived|nmod|incubations products|acl|derived separation|nmod|products studied|nmod|separation studied|nsubjpass|ability ability|acl|convert convert|dep|arachidonic_acid arachidonic_acid|nmod|products products|amod|END_ENTITY	The ability of rabbit fetal membranes to convert arachidonic_acid to both lipoxygenase and cyclooxygenase products was studied by separation and identification of products derived from incubations of 1-14C-arachidonate with subcellular fractions obtained by differential centrifugation of tissue homogenates .
8741332	2	1-14Carachidonic_acid	335,356	PGD2	244,248	1-14Carachidonic acid	PGD2	null	374110(Tax:9031)	Chemical	Gene	labeling|nmod|START_ENTITY using|advcl|labeling evaluated|xcomp|using evaluated|nsubjpass|production production|nmod|END_ENTITY	The production of PGD2 was evaluated using thin layer chromatography -LRB- TLC -RRB- after labeling the RPE cells with 1-14Carachidonic_acid -LRB- AA -RRB- and radioimmunoassay -LRB- RIA -RRB- .
16413734	4	1,14-carbonate	608,622	C-7	653,656	1,14-carbonate	C-7	null	730	Chemical	Gene	moiety|amod|START_ENTITY presence|nmod|moiety nature|conj|presence nature|conj|substituent substituent|nmod|END_ENTITY	Affinity resulted significantly affected by the nature of the isoserinic side chain , the presence of the 1,14-carbonate moiety and the substituent at C-7 , showing that the hydrophobicity of the drug is fundamental in the binding process .
4069292	4	1-14C-glucose	933,946	CO2	702,705	1-14C-glucose	CO2	null	717	Chemical	Gene	found|advcl|START_ENTITY higher|advcl|found higher|nsubj|rate rate|nmod|production production|compound|END_ENTITY	The rate of labeled CO2 production from 6-14C-glucose , 1,5-14C-citric _ acid and U-14C-glutamine was about 2 times higher in melanotic melanomas than in amelanotic one , while no significant differences among the three melanomas were found in respect to 1-14C-glucose and U-14C-glycerol-3-phosphate .
597516	1	1-14C-glucose	186,199	CO2	366,369	1-14C-glucose	CO2	null	717	Chemical	Gene	metabolization|amod|START_ENTITY rate|nmod|metabolization studied|nmod|rate studied|conj|labelled labelled|nmod|cells cells|acl|assimilating assimilating|xcomp|incapable incapable|nmod|reassimilation reassimilation|nmod|END_ENTITY	The effect of phosphorylation on glycolysis reactions was studied in respect with the rate of 1-14C-glucose metabolization and the composition of synthesized labelled products in isolated cells of assimilating millet leave tissues incapable to reassimilation of respiratory CO2 .
967015	1	1-14C-glucose	161,174	insulin	150,157	1-14C-glucose	insulin	null	3630	Chemical	Gene	conversion|amod|START_ENTITY END_ENTITY|nmod|conversion	The effect of varying concentrations of insulin on 1-14C-glucose conversion to 14CO2 was measured in subcutaneous adipose tissue samples obtained from 16 obese human subjects -LRB- 10 nondiabetic , 6 diabetic -RRB- .
967015	4	1-14C-glucose	740,753	insulin	717,724	1-14C-glucose	insulin	null	3630	Chemical	Gene	oxidation|amod|START_ENTITY sensitivity|nmod|oxidation sensitivity|compound|END_ENTITY	There was , over-all , a significant correlation between Kins and Kitt , indicating that insulin sensitivity of 1-14C-glucose oxidation by adipose tissue in vitro reflects the general state of sensitivity of glucose metabolism to insulin in vivo in obese human subjects .
967015	4	1-14C-glucose	740,753	insulin	858,865	1-14C-glucose	insulin	null	3630	Chemical	Gene	oxidation|amod|START_ENTITY sensitivity|nmod|oxidation indicating|dobj|sensitivity over-all|acl|indicating reflects|nsubj|over-all reflects|nmod|END_ENTITY	There was , over-all , a significant correlation between Kins and Kitt , indicating that insulin sensitivity of 1-14C-glucose oxidation by adipose tissue in vitro reflects the general state of sensitivity of glucose metabolism to insulin in vivo in obese human subjects .
6352541	3	1-14C-glycine	787,800	insulin	732,739	1-14C-glycine	insulin	null	396145(Tax:9031)	Chemical	Gene	labelling|advcl|START_ENTITY increase|acl|labelling produced|dobj|increase produced|nsubj|Tri-iodo-thyronine Tri-iodo-thyronine|conj|END_ENTITY	Tri-iodo-thyronine and insulin produced a 200 % increase in 14C labelling from 1-14C-glycine .
7136756	2	1-14C-labelled_amino_acids	483,509	ornithine_decarboxylase	400,423	1-14C-labelled amino acids	ornithine decarboxylase	null	18263(Tax:10090)	Chemical	Gene	assayed|nmod|START_ENTITY activities|dep|assayed activities|nmod|lysine lysine|conj|END_ENTITY	Administration of nandrolone resulted in an increased kidney weight and elevated activities of lysine and ornithine_decarboxylase -LRB- assayed by measurement of the formation of 14CO2 from the 1-14C-labelled_amino_acids -RRB- .
3942774	1	1-14C-labelled_hepoxilin_A3	84,111	epoxide_hydratase	268,285	1-14C-labelled hepoxilin A3	epoxide hydratase	null	65030(Tax:10116)	Chemical	Gene	generated|dep|START_ENTITY generated|dep|lacking lacking|dobj|activity activity|amod|END_ENTITY	1-14C-labelled_hepoxilin_A3 -LRB- 8-hydroxy-11 ,12 - epoxyeicosa-5 ,9,14 - trienoic_acid -RRB- was generated from 1-14C-labelled arachidonic_acid during incubation with a rat lung preparation lacking epoxide_hydratase activity .
410288	1	1-14C-lactose	87,100	lactase	171,178	1-14C-lactose	lactase	null	3938	Chemical	Gene	test|amod|START_ENTITY value|nmod|test compared|nsubjpass|value compared|nmod|test test|conj|assay assay|compound|END_ENTITY	The diagnostic value of 1-14C-lactose breath test was compared with the standard lactose tolerance test and lactase assay in jejunal biopsies in 16 control subjects , 14 patients with lactase_deficiency -LRB- LD -RRB- proven by lactase assay and 20 patients with irritable_bowel_syndrome -LRB- IBS -RRB- .
410288	1	1-14C-lactose	87,100	lactase	280,287	1-14C-lactose	lactase	null	3938	Chemical	Gene	test|amod|START_ENTITY value|nmod|test compared|nsubjpass|value compared|nmod|subjects subjects|appos|patients patients|nmod|lactase_deficiency lactase_deficiency|acl|proven proven|nmod|assay assay|amod|END_ENTITY	The diagnostic value of 1-14C-lactose breath test was compared with the standard lactose tolerance test and lactase assay in jejunal biopsies in 16 control subjects , 14 patients with lactase_deficiency -LRB- LD -RRB- proven by lactase assay and 20 patients with irritable_bowel_syndrome -LRB- IBS -RRB- .
410288	4	1-14C-lactose	708,721	lactase	891,898	1-14C-lactose	lactase	null	3938	Chemical	Gene	test|amod|START_ENTITY superior|nsubj|test superior|conj|correlation correlation|nmod|absorption absorption|conj|assay assay|compound|END_ENTITY	1-14C-lactose breath test was superior to standard lactose tolerance test in specificity -LRB- P less than 0.05 -RRB- and provided a satisfactory correlation between 14C-lactose absorption and lactase assay -LRB- r = 0.77 -RRB- .
10232692	1	1-14C_leucine	514,527	insulin	411,418	1-14C leucine	insulin	null	3630	Chemical	Gene	infusion|amod|START_ENTITY calorimetry|conj|infusion combination|nmod|calorimetry performed|nmod|combination performed|nsubjpass|studies studies|compound|END_ENTITY	Euglycemic insulin clamp studies -LRB- 180 min -RRB- were performed in combination with continuous indirect calorimetry and 1-14C_leucine infusion -LRB- study I -RRB- .
1568347	2	1-14C-leucine	366,379	GH	407,409	1-14C-leucine	GH	null	2688	Chemical	Gene	infusion|amod|START_ENTITY using|dobj|infusion using|nmod|administration administration|compound|END_ENTITY	DESIGN : Whole body leucine kinetics were measured in post-absorptive conditions using a 1-14C-leucine infusion before and during GH administration -LRB- 0.0125 mg/kg/day ; 0.033 U/kg/day -RRB- for 7 days .
11858764	4	1-14C-linoleic_acid	803,822	delta-6_desaturase	696,714	1-14C-linoleic acid	delta-6 desaturase	null	83512(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY fraction|acl|using determined|nmod|fraction determined|nsubjpass|activity activity|amod|END_ENTITY	The hepatic delta-6_desaturase activity in hHTg rats was determined radiometrically in a microsomal fraction using the 1-14C-linoleic_acid as substrate .
3201996	2	1-14C_linolenate_n6	605,624	delta_6_desaturase	516,534	1-14C linolenate n6	delta 6 desaturase	null	83512(Tax:10116)	Chemical	Gene	measured|nmod|START_ENTITY activity|acl|measured activity|amod|END_ENTITY	In liver and kidney this correlated with a significant decrease in the first dietary condition , and with an increase in the second , of delta_6_desaturase activity , measured by the rate of conversion of 1-14C linoleate n6 to 1-14C_linolenate_n6 .
1858038	4	1-14C-palmitate	896,911	IL-1_alpha	770,780	1-14C-palmitate	IL-1 alpha	null	24493(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY mRNA|conj|oxidation increased|dobj|mRNA increased|nsubj|END_ENTITY	We showed that IL-1_alpha significantly increased CPT mRNA , 35S-methionine incorporation CPT protein , and hepatic mitochondrial oxidation of 1-14C-palmitate to acid soluble products .
14732449	4	1-14C-palmitate	496,511	leptin	662,668	1-14C-palmitate	leptin	null	396832(Tax:9823)	Chemical	Gene	U-14C-glucose|conj|START_ENTITY metabolism|amod|U-14C-glucose assessed|dobj|metabolism assessed|parataxis|control control|conj|END_ENTITY	Experiments assessed U-14C-glucose or 1-14C-palmitate metabolism in isolated adipocytes exposed to : basal medium -LRB- control -RRB- , 100 nM insulin , 100 ng/ml porcine growth hormone , 100 ng/ml recombinant porcine leptin , and combinations of these hormones .
1701451	3	1-14C-propionate	676,692	methylmalonyl-CoA_mutase	619,643	1-14C-propionate	methylmalonyl-CoA mutase	null	688517(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY activity|appos|production activity|amod|END_ENTITY	Consistent with decreased methylmalonyl-CoA_mutase activity , 14CO2 production from 1-14C-propionate -LRB- 1 mM -RRB- was decreased by 76 % and 82 % after 2-3 wk and 5-6 wk of HCCL treatment , respectively .
3405240	1	1-14C_pyruvate	154,168	CO2	134,137	1-14C pyruvate	CO2	null	717	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|dobj|production production|compound|END_ENTITY	L-carnitine stimulated CO2 production from 1-14C_pyruvate in mitochondria from human skeletal muscle nearly twofold .
23943853	7	11525A	903,909	hAGT	852,856	11525A	hAGT	null	183	Chemical	Gene	allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|nmod|3 3|amod|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
23943853	7	11525A	903,909	miR-31	812,818	11525A	miR-31	null	407035	Chemical	Gene	allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
23943853	7	11525A	903,909	miR-584	823,830	11525A	miR-584	null	693169	Chemical	Gene	allele|nummod|START_ENTITY allele|nmod|allele containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|miR-31 miR-31|conj|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
23943853	7	11525C	875,881	hAGT	852,856	11525C	hAGT	null	183	Chemical	Gene	allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|nmod|3 3|amod|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
23943853	7	11525C	875,881	miR-31	812,818	11525C	miR-31	null	407035	Chemical	Gene	allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
23943853	7	11525C	875,881	miR-584	823,830	11525C	miR-584	null	693169	Chemical	Gene	allele|nummod|START_ENTITY containing|dobj|allele show|xcomp|containing show|dobj|bind bind|amod|miR-31 miR-31|conj|END_ENTITY	We show here that miR-31 and miR-584 bind strongly to the hAGT 3 ' - UTR containing 11525C allele compared with 11525A allele .
25049736	4	1153C	523,528	TYRP1	569,574	1153C	TYRP1	null	7306	Chemical	Gene	_|compound|START_ENTITY _|conj|_ SNPs|dep|_ found|nsubjpass|SNPs found|nmod|region region|nmod|gene gene|compound|END_ENTITY	Two SNPs -LRB- 367T _ > _ C and 1153C _ > _ T -RRB- were found in the coding region of TYRP1 gene , but had no significant association with plumage phenotype in Korean quails .
16299517	3	1,157-nucleotide	333,349	TLC1	380,384	1,157-nucleotide	TLC1	null	9164870	Chemical	Gene	RNA|amod|START_ENTITY RNA|compound|END_ENTITY	Here , we reduce the 1,157-nucleotide -LRB- nt -RRB- Saccharomyces_cerevisiae TLC1 RNA to a size smaller than the 451-nt human RNA while retaining function in vivo .
8483502	2	115_amino-acid	324,338	IL-5	281,285	115 amino-acid	IL-5	null	3567	Chemical	Gene	residues|amod|START_ENTITY homodimer|nmod|residues homodimer|nsubj|END_ENTITY	Human IL-5 is a disulphide-linked homodimer with 115_amino-acid residues in each chain .
731729	1	115mCd	200,206	Cd2	184,187	115mCd	Cd2	null	497761(Tax:10116)	Chemical	Gene	containing|dobj|START_ENTITY +|acl|containing +|compound|END_ENTITY	-LSB- 3_H -RSB- _ Cystine and 115mCd were incorporated into hepatic and renal Cd-thionein in response to sc administration of 4.4 mumol of Cd2 + containing 115mCd .
731729	1	115mCd	75,81	Cd2	184,187	115mCd	Cd2	null	497761(Tax:10116)	Chemical	Gene	Cystine|conj|START_ENTITY sc|nsubj|Cystine sc|dobj|administration administration|nmod|mumol mumol|nmod|+ +|compound|END_ENTITY	-LSB- 3_H -RSB- _ Cystine and 115mCd were incorporated into hepatic and renal Cd-thionein in response to sc administration of 4.4 mumol of Cd2 + containing 115mCd .
731729	2	115mCd	226,232	Cd2	276,279	115mCd	Cd2	null	497761(Tax:10116)	Chemical	Gene	reached|nsubj|START_ENTITY reached|nmod|injection injection|amod|END_ENTITY	Cd-thionein-bound 115mCd reached a plateau by 24 and 72 h after the Cd2 + injection in liver and kidney , respectively .
9218510	7	116-123	915,922	MBP	870,873	116-123	MBP	MESH:C477353	4155	Chemical	Gene	MBP|appos|START_ENTITY corresponded|nmod|MBP corresponded|nsubj|epitope epitope|nmod|recognition recognition|compound|END_ENTITY	The major T cell epitope for MBP recognition corresponded to residues MBP -LRB- 116-123 -RRB- .
9218510	7	116-123	915,922	MBP	911,914	116-123	MBP	MESH:C477353	4155	Chemical	Gene	END_ENTITY|appos|START_ENTITY	The major T cell epitope for MBP recognition corresponded to residues MBP -LRB- 116-123 -RRB- .
21593163	1	1,162-amino-acid	206,222	LANA	195,199	1,162-amino-acid	LANA	null	4961527(Tax:37296)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|latency-associated_nuclear_antigen latency-associated_nuclear_antigen|appos|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated_nuclear_antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that acts on viral terminal repeat -LRB- TR -RRB- DNA to mediate KSHV episome persistence .
24006437	1	1,162-amino-acid	230,246	LANA	219,223	1,162-amino-acid	LANA	null	4961527(Tax:37296)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|antigen antigen|appos|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated nuclear antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that mediates the maintenance of episomal viral genomes in latently infected cells .
21593163	1	1,162-amino-acid	206,222	latency-associated_nuclear_antigen	159,193	1,162-amino-acid	latency-associated nuclear antigen	null	4961527(Tax:37296)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- latency-associated_nuclear_antigen -LRB- LANA -RRB- is a 1,162-amino-acid protein that acts on viral terminal repeat -LRB- TR -RRB- DNA to mediate KSHV episome persistence .
14558925	2	116-amino_acid_polypeptide_prohormone	254,291	CALC-1	221,227	116-amino acid polypeptide prohormone	CALC-1	MESH:C477353	796	Chemical	Gene	products|nmod|START_ENTITY products|compound|END_ENTITY	Other CALC-1 gene products such as the 116-amino_acid_polypeptide_prohormone , procalcitonin , as well as its component calcitonin precursors -LRB- CTpr -RRB- may also be increased in their sera .
14558925	2	116-amino_acid_polypeptide_prohormone	254,291	calcitonin	333,343	116-amino acid polypeptide prohormone	calcitonin	MESH:C477353	796	Chemical	Gene	START_ENTITY|appos|procalcitonin procalcitonin|conj|precursors precursors|compound|END_ENTITY	Other CALC-1 gene products such as the 116-amino_acid_polypeptide_prohormone , procalcitonin , as well as its component calcitonin precursors -LRB- CTpr -RRB- may also be increased in their sera .
18075234	2	116-amino_acid_propeptide	174,199	calcitonin	203,213	116-amino acid propeptide	calcitonin	MESH:C054836	796	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Procalcitonin -LRB- PCT -RRB- , a 116-amino_acid_propeptide of calcitonin , is a new marker of bacterial_infections and sepsis .
18086127	5	116-glutamine	1021,1034	Bdnf	823,827	116-glutamine	Bdnf	MESH:C477353	12064(Tax:10090)	Chemical	Gene	tract|amod|START_ENTITY express|nmod|tract mice|acl:relcl|express forebrain|nmod|mice BDNF|nmod|forebrain II|nmod|BDNF kinase|dep|II kinase|dep|employed employed|dep|driven driven|nsubj|transgene transgene|compound|END_ENTITY	We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract .
18086127	5	116-glutamine	1021,1034	BDNF	940,944	116-glutamine	BDNF	MESH:C477353	12064(Tax:10090)	Chemical	Gene	tract|amod|START_ENTITY express|nmod|tract mice|acl:relcl|express forebrain|nmod|mice END_ENTITY|nmod|forebrain	We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract .
18086127	5	116-glutamine	1021,1034	htt	1010,1013	116-glutamine	htt	MESH:C477353	15194(Tax:10090)	Chemical	Gene	tract|amod|START_ENTITY express|nmod|tract express|dobj|fragment fragment|nmod|END_ENTITY	We employed a Bdnf transgene driven by the promoter for the alpha subunit of Ca -LRB- 2 + -RRB- / calmodulin-dependent kinase II to over-express BDNF in the forebrain of R6/1 mice which express a fragment of mutant htt with a 116-glutamine tract .
7958949	2	1173-amino-acid	244,259	cKr2	206,210	1173-amino-acid	cKr2	null	396155(Tax:9031)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein cDNA|acl:relcl|encodes cDNA|nsubj|END_ENTITY	cKr2 is a 4492-bp cDNA that encodes a 1173-amino-acid -LRB- aa -RRB- protein with two domains : the N-terminal portion contains 16 zinc fingers -LRB- Zf -RRB- of the 2Cys + 2His class , while the C-terminal domain contains a stretch of 181 aa which consists of seven consecutive sequence repeats each being 24 aa in length .
15358623	7	1173CC	1088,1094	VKORC1	1081,1087	1173CC	VKORC1	MESH:D002996	79001	Chemical	Gene	genotype|nummod|START_ENTITY genotype|compound|END_ENTITY	Regardless of the presence of confounding variables , the mean adjusted dose required of warfarin was higher -LRB- 6.2 mg -RRB- among patients with the VKORC1 1173CC genotype than those of patients carrying the CT -LRB- 4.8 mg ; P = .002 -RRB- or the TT genotype -LRB- 3.5 mg ; P < .001 -RRB- .
18240904	8	1173_TC	1604,1611	VKORC1	1597,1603	1173 TC	VKORC1	MESH:C078891	79001	Chemical	Gene	START_ENTITY|nummod|END_ENTITY	For the Japanese cardiovascular surgery patients , the maintenance dose of warfarin was significantly larger in the combined VKORC1 1173_TC and CC genotype group than in the 1173 TT genotype group -LRB- 3.6 + / - 0.5 mg vs 2.8 + / - 0.7 mg , respectively ; p = 0.02 -RRB- .
25301491	5	1174C	1201,1206	WFS1	1096,1100	1174C	WFS1	null	7466	Chemical	Gene	_|nummod|START_ENTITY substitution|dep|_ frameshift|conj|substitution leading|nmod|frameshift found|parataxis|leading found|xcomp|heterozygote heterozygote|nmod|mutations mutations|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	The patient was found to be a compound heterozygote for two novel mutations in exon 8 of WFS1 gene : a 2-bp deletion AT at nt 1539 leading to a frameshift -LRB- Y513fs -RRB- and a single-base substitution 1174C _ > _ T resulting in a stop codon -LRB- Q392X -RRB- .
27159682	2	11778G	445,451	MT-ND4	460,466	11778G	MT-ND4	null	4538	Chemical	Gene	___|compound|START_ENTITY >|nummod|___ carrying|dobj|> families|acl|carrying DNA|nmod|families analysis|nmod|DNA report|dobj|analysis report|xcomp|___ ___|dobj|mutation mutation|appos|END_ENTITY	We report here the clinical , genetic and molecular analysis of mitochondrial DNA -LRB- mtDNA -RRB- in eight Han Chinese families carrying the known mitochondrial 11778G ___ > ___ A -LRB- MT-ND4 -RRB- mutation .
9784061	2	1177-amino-acid	305,320	DBP	229,232	1177-amino-acid	DBP	null	1628	Chemical	Gene	polypeptide|amod|START_ENTITY coding|dobj|polypeptide capable|advcl|coding nucleotides|amod|capable frame|nmod|nucleotides has|dobj|frame has|nsubj|gene gene|compound|END_ENTITY	The DBP gene has an open reading frame of 3531 nucleotides , capable of coding a 1177-amino-acid polypeptide of 125 kDa .
22433867	8	117-amino_acid	1294,1308	huntingtin	1270,1280	117-amino acid	huntingtin	MESH:C071047	3064	Chemical	Gene	fragment|amod|START_ENTITY shortstop|appos|fragment shortstop|compound|END_ENTITY	Interestingly , comparable oligomeric species were not observed for expanded huntingtin shortstop , a 117-amino_acid fragment of huntingtin shown previously in mammalian cell lines and transgenic_mice , and here in primary cortical neurons , to be non-toxic .
22433867	8	117-amino_acid	1294,1308	huntingtin	1321,1331	117-amino acid	huntingtin	MESH:C071047	3064	Chemical	Gene	fragment|amod|START_ENTITY fragment|nmod|END_ENTITY	Interestingly , comparable oligomeric species were not observed for expanded huntingtin shortstop , a 117-amino_acid fragment of huntingtin shown previously in mammalian cell lines and transgenic_mice , and here in primary cortical neurons , to be non-toxic .
26489467	4	117-amino-acid	483,497	CRM1	555,559	117-amino-acid	CRM1	null	7514	Chemical	Gene	fragment|amod|START_ENTITY fragment|nmod|complex complex|nmod|END_ENTITY	Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution .
26489467	4	117-amino-acid	483,497	Nup214	531,537	117-amino-acid	Nup214	null	8021	Chemical	Gene	fragment|amod|START_ENTITY fragment|nmod|END_ENTITY	Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution .
7490091	5	117-amino-acid	741,755	ribosomal_protein_L34	786,807	117-amino-acid	ribosomal protein L34	null	362041(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY encoding|dobj|protein encoding|nmod|END_ENTITY	A full-length cDNA clone encoding a 117-amino-acid protein homologous to the rat ribosomal_protein_L34 was isolated .
26489467	4	117-amino-acid	483,497	Snurportin_1	561,573	117-amino-acid	Snurportin 1	null	10073	Chemical	Gene	fragment|amod|START_ENTITY fragment|nmod|complex complex|nmod|CRM1 CRM1|conj|END_ENTITY	Here , we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214 , in complex with CRM1 , Snurportin_1 , and RanGTP at 2.85 resolution .
21411255	4	1181G	861,866	TNFRSF11B	807,816	1181G	TNFRSF11B	null	4982	Chemical	Gene	C|nummod|START_ENTITY G|conj|C G|compound|END_ENTITY	STUDY DESIGN : 478 postmenopausal women were genotyped for the presence of TNFRSF11B gene polymorphisms 245T _ > _ G -LRB- rs3134069 -RRB- and 1181G _ > _ C -LRB- rs2073618 -RRB- .
10381377	3	1183-amino-acid	395,410	SHIP2	374,379	1183-amino-acid	SHIP2	MESH:C403900	65038(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY	Rat SHIP2 cDNA encodes a 1183-amino-acid protein that is 45 % identical with rat SHIP .
14617087	5	1188-amino-acid	497,512	BRI1	562,566	1188-amino-acid	BRI1	null	830095(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|acl:relcl|has has|nmod|END_ENTITY	PsBRI1 is predicted to encode a 1188-amino-acid protein that has 78 % similarity with Arabidopsis BRI1 .
1415682	2	1-188_amino_acids	735,752	lipocortin-1	763,775	1-188 amino acids	lipocortin-1	null	301	Chemical	Gene	fragment|dep|START_ENTITY fragment|nmod|END_ENTITY	Administration -LRB- icv -RRB- of a recombinant fragment -LRB- NH2-terminus , 1-188_amino_acids -RRB- of human lipocortin-1 -LRB- 1.2 micrograms -RRB- produced small increases in VO2 -LRB- < 5 % -RRB- and body temperature -LRB- < 0.3 degrees C -RRB- .
19706609	5	11894-11899	914,925	SULT1A1	839,846	11894-11899	SULT1A1	MESH:C090474	6817	Chemical	Gene	Biochemistry|nummod|START_ENTITY G.|dep|Biochemistry Tyapochkin|conj|G. END_ENTITY|dep|Tyapochkin	Previously , isotope exchange at equilibrium indicated steady-state ordered mechanism with PAPS and PAP binding to the free SULT1A1 -LRB- Tyapochkin , E. , Cook , P. F. , and Chen , G. -LRB- 2008 -RRB- Biochemistry 47 , 11894-11899 -RRB- .
10673031	5	118-amino-acid	564,578	RAD52beta	611,620	118-amino-acid	RAD52beta	null	201299	Chemical	Gene	residues|amod|START_ENTITY -|conj|residues consist|nmod|- consist|conj|designated designated|nmod|END_ENTITY	The three isoforms consist of 226 - , 139 - , and 118-amino-acid residues , and are designated as RAD52beta , gamma , and delta , respectively .
12737519	5	118-amino-acid	1160,1174	RAP30	1084,1089	118-amino-acid	RAP30	null	2963	Chemical	Gene	residuals|amod|START_ENTITY RMP|nmod|residuals domain|nmod|RMP interact|nmod|domain interact|nsubj|END_ENTITY	Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain .
12737519	5	118-amino-acid	1160,1174	RAP74	1094,1099	118-amino-acid	RAP74	null	2962	Chemical	Gene	residuals|amod|START_ENTITY RMP|nmod|residuals domain|nmod|RMP interact|nmod|domain interact|nsubj|RAP30 RAP30|conj|END_ENTITY	Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain .
12737519	5	118-amino-acid	1160,1174	RMP	1153,1156	118-amino-acid	RMP	null	8725	Chemical	Gene	residuals|amod|START_ENTITY END_ENTITY|nmod|residuals	Interestingly both RAP30 and RAP74 interact with the same domain -LRB- D5 -RRB- of the C-terminal RMP of 118-amino-acid residuals which overlaps with its TFIIB-binding domain .
19332070	5	118-amino_acids	905,920	CART	885,889	118-amino acids	CART	null	100286783(Tax:8030)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The CART gene , encoding 118-amino_acids , was strongly expressed in the brain and eye .
15936720	9	11-9-1-4	1060,1068	c-fos	1015,1020	11-9-1-4	c-fos	MESH:C087567	2353	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Ro5-4864 also upregulates c-fos expression in breast_cancer cell lines 11-9-1-4 and BT-549 , while expression in non-tumorigenic cell line MCF-12A was either basal or slightly downregulated .
15936720	10	11-9-1-4	1248,1256	CPT	1221,1224	11-9-1-4	CPT	MESH:C087567	56994	Chemical	Gene	breast_cancer|appos|START_ENTITY examined|nmod|breast_cancer examined|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	We further examined the expression of the CPT gene in breast_cancer -LRB- 11-9-1-4 , BT-549 -RRB- and non-tumorigenic cell lines -LRB- MCF-12A , MCF-12F -RRB- .
1283051	3	1194P	1324,1329	IRBP	1273,1277	1194P	IRBP	null	19661(Tax:10090)	Chemical	Gene	proline|nummod|START_ENTITY END_ENTITY|conj|proline	On the other hand , two amino_acids of IRBP , amino_acid positions 1182W -LRB- tryptophane -RRB- and 1194P -LRB- proline -RRB- were shown to be the agretopes inducing autoimmune_uveoretinitis in the TG nude mouse .
19123050	4	1199A	585,590	MDR1	564,568	1199A	MDR1	null	5243	Chemical	Gene	MDR1|appos|START_ENTITY END_ENTITY|conj|MDR1	RESULTS : The recombinant cells MDR1 -LRB- wt -RRB- and MDR1 -LRB- 1199A -RRB- displayed comparable doxorubicin resistance .
19123050	4	1199A	585,590	MDR1	578,582	1199A	MDR1	null	5243	Chemical	Gene	END_ENTITY|appos|START_ENTITY	RESULTS : The recombinant cells MDR1 -LRB- wt -RRB- and MDR1 -LRB- 1199A -RRB- displayed comparable doxorubicin resistance .
23716179	11	119G	1501,1505	TP53	1510,1514	119G	TP53	null	7157	Chemical	Gene	polymorphism|nummod|START_ENTITY polymorphism|compound|END_ENTITY	We conclude that the Ex4 _ + _ 119G _ > _ C TP53 polymorphism is an independent , low penetrance marker of BC risk in this population .
23716179	12	119G	1664,1668	TP53	1673,1677	119G	TP53	null	7157	Chemical	Gene	C|nummod|START_ENTITY C|nummod|END_ENTITY	In addition , our findings suggest that the combination of Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 genotypes confers a higher risk to develop BC .
23716179	13	119G	1787,1791	TP53	1796,1800	119G	TP53	null	7157	Chemical	Gene	genotype|nummod|START_ENTITY genotype|compound|END_ENTITY	Also , a possible association of the Ex4 _ + _ 119G _ > _ C TP53 genotype with decreased disease-free survival in these patients is proposed .
23716179	8	119G	1051,1055	TP53	1060,1064	119G	TP53	null	7157	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Carriers of at least one Pro allele of the Ex4 _ + _ 119G _ > _ C TP53 polymorphism presented a significant BC risk -LSB- OR = 1.34 , -LRB- 95 % CI 1.03-1 .75 -RRB- , p value = 0.029 -RSB- .
23716179	9	119G	1265,1269	TP53	1274,1278	119G	TP53	null	7157	Chemical	Gene	END_ENTITY|compound|START_ENTITY	The epistatic gene-gene analysis showed that the best two-locus model was the combination between Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 showing OR of 1.44 -LRB- 95 % CI 1.10-1 .88 , p value = 0.0083 -RRB- .
23716179	12	119G	1664,1668	VEGFR1	1691,1697	119G	VEGFR1	null	2321	Chemical	Gene	C|nummod|START_ENTITY C|conj|genotypes genotypes|compound|END_ENTITY	In addition , our findings suggest that the combination of Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 genotypes confers a higher risk to develop BC .
23716179	9	119G	1265,1269	VEGFR1	1292,1298	119G	VEGFR1	null	2321	Chemical	Gene	TP53|compound|START_ENTITY TP53|conj|END_ENTITY	The epistatic gene-gene analysis showed that the best two-locus model was the combination between Ex4 _ + _ 119G _ > _ C TP53 and -710 _ C/T VEGFR1 showing OR of 1.44 -LRB- 95 % CI 1.10-1 .88 , p value = 0.0083 -RRB- .
20370508	11	11A	1765,1768	19A	1760,1763	11A	19A	null	57823	Chemical	Gene	END_ENTITY|appos|START_ENTITY	Of particular concern was the high prevalence of MDR pneumococci in non-PCV7 serotypes with an MDR serotype 19A , 11A , 3 , and 6A being mostly responsible .
20370508	2	11A	438,441	19A	428,431	11A	19A	null	57823	Chemical	Gene	19F|amod|START_ENTITY 19F|amod|END_ENTITY	The predominant serotypes were 19F , 19A , 23F , 11A , 3 , 6A , and 6B , accounting for 67.8 % of all isolates .
20370508	8	11A	1384,1387	19A	1370,1373	11A	19A	null	57823	Chemical	Gene	END_ENTITY|conj|START_ENTITY	MDR strains were relatively associated with serotypes 19F , 19A , 23F , and 11A , accounting for 58.0 % of the isolates .
22440017	12	11A	1686,1689	19A	1611,1614	11A	19A	null	57823	Chemical	Gene	6B|appos|START_ENTITY isolated|nsubjpass|6B found|parataxis|isolated found|nsubjpass|Serotypes Serotypes|nummod|END_ENTITY	Serotypes 15B , 19A and 21 were mainly found as single carriage ; in contrast serotypes 6B , 11A and 20 , as well as infrequent serotypes , were isolated mainly as part of multiple carriage .
26226445	11	11A	1249,1252	19A	1237,1240	11A	19A	null	57823	Chemical	Gene	35B|conj|START_ENTITY 35B|conj|END_ENTITY	Commonly carried serotypes included 35B -LRB- 15.2 % -RRB- , 15B/C -LRB- 14.2 % -RRB- , 19A -LRB- 9.6 % -RRB- , 11A -LRB- 8 % -RRB- , 23B -LRB- 5.6 % -RRB- , 6C -LRB- 5.3 % -RRB- , 21 -LRB- 5 % -RRB- , and 15A -LRB- 5 % -RRB- ; 13.9 % were PCV13 serotypes .
28776337	4	11A	805,808	19A	764,767	11A	19A	null	57823	Chemical	Gene	END_ENTITY|conj|START_ENTITY	The most common serotypes were 19A -LRB- 14.0 % -RRB- , 23A -LRB- 12.8 % -RRB- , 15B/C -LRB- 10.7 % -RRB- , 11A -LRB- 10.1 % -RRB- , 6C -LRB- 7.8 % -RRB- , and 6A -LRB- 6.3 % -RRB- among the typeable pneumococci -LRB- n = 335 -RRB- .
3106148	5	11A	917,920	cac	929,932	11A	cac	null	32158(Tax:7227)	Chemical	Gene	Duplications|nmod|START_ENTITY covered|nsubj|Duplications covered|dobj|END_ENTITY	Duplications including distal 11A covered cac .
28340620	7	11A4H	1492,1497	FVIII	1357,1362	11A4H	FVIII	null	2157	Chemical	Gene	line|dep|START_ENTITY IU/ml|dep|line secreted|dobj|IU/ml cells|acl|secreted END_ENTITY|dep|cells	Immediately after the primary selection FVIII - producing cells secreted 5-10 IU/ml of FVIII-BDD , and after multi-stage methotrexate-driven amplification a stable clonal line 11A4H was selected , secreting 39 IU/ml of FVIII-BDD in the simple batch culturing conditions , which considerably exceeds known indicators for industrial producers of this protein .
28340620	8	11A4H	1720,1725	FVIII	1769,1774	11A4H	FVIII	null	2157	Chemical	Gene	accumulates|nsubj|START_ENTITY accumulates|dobj|proportion proportion|nmod|END_ENTITY	In contrast to other FVIII-BDD producing lines 11A4H accumulates low proportion of the secreted FVIII on the membrane .
8630880	1	11A8-SAP	332,340	basic_fibroblast_growth_factor	237,267	11A8-SAP	basic fibroblast growth factor	null	2247	Chemical	Gene	forms|conj|START_ENTITY forms|nmod|saporin saporin|compound|END_ENTITY	BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice .
8630880	1	11A8-SAP	332,340	bFGF	269,273	11A8-SAP	bFGF	null	2247	Chemical	Gene	forms|conj|START_ENTITY forms|nmod|saporin saporin|appos|END_ENTITY	BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice .
8630880	1	11A8-SAP	332,340	bFGF	297,301	11A8-SAP	bFGF	null	2247	Chemical	Gene	START_ENTITY|amod|END_ENTITY	BACKGROUND : The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic_fibroblast_growth_factor -LRB- bFGF -RRB- saporin -LRB- SAP -RRB- and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian_teratocarcinoma PA-1 was examined in athymic nude_mice .
10073575	7	11A_and_B	1064,1073	HNF-3alpha	1019,1029	11A and B	HNF-3alpha	null	3169	Chemical	Gene	Cotransfection|conj|START_ENTITY Cotransfection|nmod|vectors vectors|nmod|END_ENTITY	Cotransfection with expression vectors of HNF-3alpha and beta , but not the related HFH 11A_and_B , specifically activated the wild-type TFF1 reporter genes .
10073575	7	11A_and_B	1064,1073	TFF1	1112,1116	11A and B	TFF1	null	7031	Chemical	Gene	Cotransfection|conj|START_ENTITY activated|nsubj|Cotransfection activated|dobj|genes genes|compound|END_ENTITY	Cotransfection with expression vectors of HNF-3alpha and beta , but not the related HFH 11A_and_B , specifically activated the wild-type TFF1 reporter genes .
17084873	3	11_acid_amides	696,710	PPARalpha	529,538	11 acid amides	PPARalpha	null	19013(Tax:10090)	Chemical	Gene	organochlorines|conj|START_ENTITY pesticides|dep|organochlorines activities|nmod|pesticides END_ENTITY|conj|activities	In the present study , we characterized mouse PPARalpha and PPARgamma agonistic activities of 200 pesticides -LRB- 29 organochlorines , _ 11_diphenyl_ethers , 56 organophosphorus pesticides , 12 pyrethroids , 22 carbamates , 11_acid_amides , 7 triazines , 8 ureas and 44 others -RRB- by in vitro reporter gene assays using CV-1 monkey kidney cells .
17084873	3	11_acid_amides	696,710	PPARgamma	543,552	11 acid amides	PPARgamma	null	19016(Tax:10090)	Chemical	Gene	organochlorines|conj|START_ENTITY pesticides|dep|organochlorines activities|nmod|pesticides activities|compound|END_ENTITY	In the present study , we characterized mouse PPARalpha and PPARgamma agonistic activities of 200 pesticides -LRB- 29 organochlorines , _ 11_diphenyl_ethers , 56 organophosphorus pesticides , 12 pyrethroids , 22 carbamates , 11_acid_amides , 7 triazines , 8 ureas and 44 others -RRB- by in vitro reporter gene assays using CV-1 monkey kidney cells .
19053888	6	11a-d	1199,1204	ABCB1	1242,1247	11a-d	ABCB1	null	5243	Chemical	Gene	N-4-methylpiperazine|dep|START_ENTITY derivatives|amod|N-4-methylpiperazine END_ENTITY|nsubj|derivatives	N-4-methylpiperazine - -LRB- 10a-d -RRB- and tetrahydroisoquinoline - -LRB- 11a-d -RRB- derivatives were Cyclosporin A-like ABCB1 nontransported substrates .
15317800	5	1,1a-dihydroxy-1-hydro-9-fluorenone	452,487	FlnB	389,393	1,1a-dihydroxy-1-hydro-9-fluorenone	FlnB	null	2317	Chemical	Gene	9-fluorenol|conj|START_ENTITY exhibited|nmod|9-fluorenol exhibited|nsubj|protein protein|compound|END_ENTITY	The FlnB protein exhibited activities against both 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone to produce 9-fluorenone and 2 ' - carboxy-2 ,3 - dihydroxybiphenyl , respectively .
22209708	4	11a-hydroxyl	710,722	C-11	685,689	11a-hydroxyl	C-11	null	51728	Chemical	Gene	group|amod|START_ENTITY removed|nsubj|group reduced|conj|removed reduced|nsubjpass|moiety moiety|nmod|END_ENTITY	Next , the carbonyl moiety at C-11 was reduced and the 11a-hydroxyl group removed through utilization of the Barton-McCombie_reaction .
22588088	1	11a-hydroxyl_canrenone	223,245	C-7	207,210	11a-hydroxyl canrenone	C-7	null	730	Chemical	Gene	4|amod|START_ENTITY position|nmod|4 position|compound|END_ENTITY	A novel and efficient method of stereoselectively introducing a-nitromethyl group to C-7 position of 11a-hydroxyl_canrenone 4 was described .
16320207	4	11alpha,13-dihydrohelenalin	749,776	IL-8	819,823	11alpha,13-dihydrohelenalin	IL-8	MESH:C026745	20309(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY that|nmod|derivatives comparable|nmod|that activity|amod|comparable possessing|dobj|activity compounds|acl|possessing gave|dobj|compounds gave|nmod|EMSA EMSA|conj|ELISA ELISA|compound|END_ENTITY	Formation of these adducts gave compounds possessing an inhibitory activity comparable to that of 11alpha,13-dihydrohelenalin derivatives in the NF-kappaB EMSA and the IL-8 ELISA in vitro assays as well as in the in vivo croton oil-induced mouse ear edema test for one adduct , namely 2beta-ethoxy-6-O-acetyl-2 ,3 - dihydrohelenalin .
9348104	5	11alpha,13-dihydrohelenalin	713,740	NF-kappaB	803,812	11alpha,13-dihydrohelenalin	NF-kappaB	MESH:C026745	4790	Chemical	Gene	degree|amod|START_ENTITY inhibit|nmod|degree inhibit|dobj|activation activation|nmod|END_ENTITY	We show here that helenalin , and , to a much lesser degree , 11alpha,13-dihydrohelenalin and chamissonolid , inhibit activation of transcription factor NF-kappaB .
17223084	3	11alpha-hydroxyprogesterone	755,782	UGT2B15	630,637	11alpha-hydroxyprogesterone	UGT2B15	MESH:C030228	7366	Chemical	Gene	zidovudine|conj|START_ENTITY substrates|amod|zidovudine testosterone|conj|substrates substrates|dobj|testosterone glucuronidated|ccomp|substrates glucuronidated|nsubj|61-194 61-194|nmod|END_ENTITY	A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone .
17223084	3	11alpha-hydroxyprogesterone	755,782	UGT2B15	657,664	11alpha-hydroxyprogesterone	UGT2B15	MESH:C030228	7366	Chemical	Gene	zidovudine|conj|START_ENTITY substrates|amod|zidovudine testosterone|conj|substrates substrates|dobj|testosterone substrates|nsubj|END_ENTITY	A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone .
17223084	3	11alpha-hydroxyprogesterone	755,782	UGT2B7	722,728	11alpha-hydroxyprogesterone	UGT2B7	MESH:C030228	7364	Chemical	Gene	zidovudine|conj|START_ENTITY substrates|amod|zidovudine substrates|nummod|END_ENTITY	A UGT2B7-15-7 chimera that incorporated amino_acids 61-194 of UGT2B15 glucuronidated the UGT2B15 substrates testosterone and phenolphthalein , but not the UGT2B7 substrates zidovudine and 11alpha-hydroxyprogesterone .
18717339	3	11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B	454,509	C21	286,289	11alpha-O-2-methylbutyryl-12beta-O-acetyl tenacigenin B	C21	null	79718	Chemical	Gene	17beta-tenacigenin_B|conj|START_ENTITY identified|nmod|17beta-tenacigenin_B extract|acl:relcl|identified isolated|nmod|extract isolated|nsubjpass|steroids steroids|compound|END_ENTITY	Eight C21 steroids were isolated from the CHCl3 extract , which were identified as 11alpha-O-tigloyl-17beta-tenacigenin_B -LRB- 1 -RRB- , 17beta-tenacigenin_B -LRB- 2 -RRB- , tenacigenoside_A -LRB- 3 -RRB- , 11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B -LRB- 4 -RRB- , tenacissoside_H -LRB- 5 -RRB- , marsdenoside_A -LRB- 6 -RRB- , tenacissoside_G -LRB- 7 -RRB- , and tenacissoside_I -LRB- 8 -RRB- .
9920094	4	11alpha-OH-progesterone	722,745	progesterone_receptor	599,620	11alpha-OH-progesterone	progesterone receptor	null	5241	Chemical	Gene	was|nsubj|START_ENTITY reversed|parataxis|was reversed|nmod|requirements requirements|dep|independent independent|nmod|END_ENTITY	Inhibition : 1 -RRB- was reversed by progesterone removal ; 2 -RRB- was independent of the progesterone_receptor -LRB- not blocked by the receptor antagonist RU40555 -RRB- ; and 3 -RRB- exhibited specific structural requirements ; 11alpha-OH-progesterone was inhibitory , whereas its stereoisomer 11beta-OH-progesterone was not .
18717339	3	11alpha-O-tigloyl-17beta-tenacigenin_B	362,400	C21	286,289	11alpha-O-tigloyl-17beta-tenacigenin B	C21	null	79718	Chemical	Gene	17beta-tenacigenin_B|amod|START_ENTITY identified|nmod|17beta-tenacigenin_B extract|acl:relcl|identified isolated|nmod|extract isolated|nsubjpass|steroids steroids|compound|END_ENTITY	Eight C21 steroids were isolated from the CHCl3 extract , which were identified as 11alpha-O-tigloyl-17beta-tenacigenin_B -LRB- 1 -RRB- , 17beta-tenacigenin_B -LRB- 2 -RRB- , tenacigenoside_A -LRB- 3 -RRB- , 11alpha-O-2-methylbutyryl-12beta-O-acetyl_tenacigenin_B -LRB- 4 -RRB- , tenacissoside_H -LRB- 5 -RRB- , marsdenoside_A -LRB- 6 -RRB- , tenacissoside_G -LRB- 7 -RRB- , and tenacissoside_I -LRB- 8 -RRB- .
20953508	1	11-amino-1-undecanethiol	125,149	serum_albumin	270,283	11-amino-1-undecanethiol	serum albumin	MESH:C510729	213	Chemical	Gene	monolayer|nmod|START_ENTITY fabricated|nsubjpass|monolayer fabricated|nmod|antibodies antibodies|conj|END_ENTITY	A self-assembled monolayer -LRB- SAM -RRB- of 11-amino-1-undecanethiol -LRB- AUT -RRB- has been fabricated onto a gold -LRB- Au -RRB- substrate to co-immobilize anti-ochratoxin-A antibodies -LRB- AO-IgGs -RRB- and bovine serum_albumin -LRB- BSA -RRB- to detect food borne mycotoxin -LSB- i.e. , ochratoxin-A -LRB- OTA -RRB- -RSB- .
18002546	3	11-amino-1-undecanethiol_hydrochloride	399,437	serum_albumin	509,522	11-amino-1-undecanethiol hydrochloride	serum albumin	null	213	Chemical	Gene	1-hexadecanethiol|amod|START_ENTITY types|acl:relcl|1-hexadecanethiol types|conj|END_ENTITY	Three types of functional alkylthiols , namely 11-amino-1-undecanethiol_hydrochloride , 1-hexadecanethiol -LRB- 1-hydrochloride , and 1,9-nonanedithiol , and bovine serum_albumin -LRB- BSA -RRB- are investigated in our study .
4448078	1	1-1-amino-3-chloro-2-propanol	57,86	HC1	87,90	1-1-amino-3-chloro-2-propanol	HC1	null	387397(Tax:10116)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	CL 88,236 -LRB- 1-1-amino-3-chloro-2-propanol HC1 -RRB- was tested orally for antifertility in male rats , mice and hamsters .
15114370	2	11_amino-acid	396,409	CEL	317,320	11 amino-acid	CEL	null	1056	Chemical	Gene	residues|amod|START_ENTITY repeats|nmod|residues structure|nmod|repeats consists|nmod|structure consists|nsubj|part part|nmod|END_ENTITY	The C-terminal part of CEL consists of a unique structure with proline-rich O-glycosylated repeats of 11_amino-acid residues each .
18284603	1	11-aminoacid	219,231	urotensin_II	200,212	11-aminoacid	urotensin II	null	10911	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY	BACKGROUND : Human urotensin_II is an 11-aminoacid peptide with a controversial role in the human cardiovascular system .
11403592	3	11-amino_acid	457,470	A_beta	508,514	11-amino acid	A beta	null	351	Chemical	Gene	fragment|amod|START_ENTITY fragment|nmod|peptide peptide|appos|END_ENTITY	Numerous laboratories have used the smaller 11-amino_acid fragment of the full-length peptide , A_beta -LRB- 25 -- 35 -RRB- , as a convenient alternative in AD investigations since the smaller peptide mimics several of the toxicological and oxidative stress properties of the native full-length peptide .
9624159	4	11-amino_acid	685,698	ACLP	597,601	11-amino acid	ACLP	MESH:D000596	11568(Tax:10090)	Chemical	Gene	motif|amod|START_ENTITY peptide|conj|motif contains|dobj|peptide protein|acl:relcl|contains protein|nsubj|END_ENTITY	ACLP is a nonnuclear protein that contains a signal peptide , a lysine - and proline-rich 11-amino_acid repeating motif , a discoidin-like domain , and a C-terminal domain with 39 % identity to carboxypeptidase_E .
8762146	3	11-amino_acid	504,517	AFP	557,560	11-amino acid	AFP	null	174	Chemical	Gene	repeats|amod|START_ENTITY repeats|appos|one one|dep|components components|compound|END_ENTITY	It has 52 amino_acids and contains four 11-amino_acid repeats , one more than the major serum AFP components .
9837942	10	11-amino_acid	1403,1416	alpha-actinin	1371,1384	11-amino acid	alpha-actinin	MESH:D000596	87	Chemical	Gene	region|amod|START_ENTITY necessary|nsubj|region regulate|parataxis|necessary regulate|dobj|END_ENTITY	Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin .
9837942	10	11-amino_acid	1403,1416	alpha-actinin	1475,1488	11-amino acid	alpha-actinin	MESH:D000596	87	Chemical	Gene	region|amod|START_ENTITY necessary|nsubj|region necessary|nmod|END_ENTITY	Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin .
9837942	10	11-amino_acid	1403,1416	alpha-actinin	1604,1617	11-amino acid	alpha-actinin	MESH:D000596	87	Chemical	Gene	region|amod|START_ENTITY necessary|nsubj|region necessary|conj|inhibits inhibits|dobj|association association|nmod|tail tail|nmod|END_ENTITY	Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin .
12534279	3	11-amino_acid	443,456	alpha-synuclein	411,426	11-amino acid	alpha-synuclein	MESH:D000596	6622	Chemical	Gene	repeats|amod|START_ENTITY comprises|dobj|repeats comprises|nsubj|N-terminus N-terminus|nmod|END_ENTITY	The N-terminus of alpha-synuclein comprises seven 11-amino_acid repeats -LRB- XKTKEGVXXXX -RRB- which can form an amphipathic alpha-helix .
3108248	5	11-amino_acid	742,755	apoA-I	676,682	11-amino acid	apoA-I	null	335	Chemical	Gene	repeats|amod|START_ENTITY consisting|nmod|repeats repetitive|xcomp|consisting homologous|conj|repetitive homologous|nmod|END_ENTITY	The sequence of the protein is homologous to mammalian apoA-I and is highly internally repetitive , consisting largely of 11-amino_acid repeats predicted to have an amphipathic alpha-helical structure .
9054424	1	11-amino_acid	183,196	Apolipoprotein_A-I	127,145	11-amino acid	Apolipoprotein A-I	null	335	Chemical	Gene	repeats|amod|START_ENTITY 22-amino_acid|conj|repeats contains|dobj|22-amino_acid contains|nsubj|END_ENTITY	Apolipoprotein_A-I contains eight 22-amino_acid and two 11-amino_acid tandem repeats that comprise 80 % of the mature protein .
28592866	6	11-amino_acid	929,942	BB0238	910,916	11-amino acid	BB0238	null	2661786(Tax:257310)	Chemical	Gene	region|amod|START_ENTITY able|nsubj|region lacking|ccomp|able lacking|nsubj|END_ENTITY	Mutant B. _ burgdorferi isolates producing BB0238 lacking the 11-amino_acid interaction region were able to persist in ticks but failed to transmit to mice or to establish infection .
9837942	10	11-amino_acid	1403,1416	beta2	1351,1356	11-amino acid	beta2	MESH:D000596	10242	Chemical	Gene	region|amod|START_ENTITY necessary|nsubj|region regulate|parataxis|necessary regulate|nsubj|domains domains|nmod|tail tail|amod|END_ENTITY	Positive and inhibitory domains within the beta2 tail regulate alpha-actinin binding : a single 11-amino_acid region -LRB- residues 736-746 -RRB- is necessary and sufficient for alpha-actinin binding , and a regulatory domain between residues 748-762 inhibits constitutive association of the beta2 tail with alpha-actinin .
16376528	2	11-amino_acid	187,200	beta-galactosidase	392,410	11-amino acid	beta-galactosidase	null	2720	Chemical	Gene	fragment|amod|START_ENTITY transduce|nsubj|fragment transduce|parataxis|shown shown|nmod|PTD PTD|nmod|protein protein|amod|END_ENTITY	An 11-amino_acid fragment of human immunodeficiency_type_1 -LRB- HIV-1 -RRB- TAT-protein can transduce large , biologically active proteins into mammalian cells ; recent evidence has shown an in vivo PTD for the 116 kDa beta-galactosidase protein .
9624159	4	11-amino_acid	685,698	carboxypeptidase_E	786,804	11-amino acid	carboxypeptidase E	MESH:D000596	12876(Tax:10090)	Chemical	Gene	motif|amod|START_ENTITY peptide|conj|motif contains|dobj|peptide contains|advcl|END_ENTITY	ACLP is a nonnuclear protein that contains a signal peptide , a lysine - and proline-rich 11-amino_acid repeating motif , a discoidin-like domain , and a C-terminal domain with 39 % identity to carboxypeptidase_E .
11350667	4	11-amino_acid	630,643	CD4	721,724	11-amino acid	CD4	null	920	Chemical	Gene	C4|amod|START_ENTITY antibodies|nmod|C4 peptide|nsubj|antibodies peptide|dep|recognize recognize|conj|bound bound|nmod|END_ENTITY	Rabbit antibodies to the 11-amino_acid linear C4 peptide did not recognize gp120 in the free state or when bound to CD4 .
10202013	0	11-amino_acid	3,16	CD40	55,59	11-amino acid	CD40	MESH:D000596	21939(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|domain domain|nmod|END_ENTITY	An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest .
10202013	0	11-amino_acid	3,16	c-Jun_N-terminal_kinase	92,115	11-amino acid	c-Jun N-terminal kinase	MESH:D000596	26419(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|nmod|END_ENTITY	An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest .
8626770	5	11-amino_acid	1695,1708	c-met	1723,1728	11-amino acid	c-met	null	4233	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|initiates initiates|amod|END_ENTITY	These findings demonstrate that the 11-amino_acid sequence from c-met initiates epithelial motility via coincident activation of the PI 3-kinase and phospholipase C and that selective activation of the PI 3-kinase can initiate a partial chemotactic response .
8618874	6	11-amino_acid	1240,1253	CPA	1312,1315	11-amino acid	CPA	null	1357	Chemical	Gene	sequence|amod|START_ENTITY homology|nmod|sequence attributable|nmod|homology attributable|nmod|sequences sequences|nmod|segments segments|nmod|END_ENTITY	This pattern of selectivity might be attributable to a limited homology of a 11-amino_acid sequence with sequences within the activation segments of CPA and CPB known to interact with residues within their active sites .
8608138	5	11-amino_acid	669,682	dematin	646,653	11-amino acid	dematin	null	2039	Chemical	Gene	motif|amod|START_ENTITY shares|dobj|motif shares|nsubj|subunit subunit|nmod|END_ENTITY	An alignment of the 22-amino_acid insertion sequence revealed that the 52 kDa subunit of dematin shares a novel 11-amino_acid motif with protein 4.2 .
1621096	3	11-amino_acid	353,366	EF-1_alpha	305,315	11-amino acid	EF-1 alpha	null	1917	Chemical	Gene	segment|amod|START_ENTITY contained|dobj|segment contained|nsubj|sequences sequences|compound|END_ENTITY	The EF-1_alpha sequences of eukaryotes contained an 11-amino_acid segment that was also found in eocytes -LRB- extremely thermophilic , sulfur-metabolizing bacteria -RRB- but that was absent in all other bacteria .
1621096	4	11-amino_acid	610,623	EF-2	562,566	11-amino acid	EF-2	null	1938	Chemical	Gene	insert|amod|START_ENTITY lacked|dobj|insert lacked|nsubj|genes genes|acl|encoding encoding|dobj|END_ENTITY	The related -LRB- paralogous -RRB- genes encoding elongation factor EF-2 and initiation factor IF-2 also lacked the 11-amino_acid insert .
7594101	1	11-amino_acid	455,468	Fab	367,370	11-amino acid	Fab	null	2187	Chemical	Gene	peptide|amod|START_ENTITY adenosine_diphosphate|conj|peptide compare|nmod|adenosine_diphosphate describe|conj|compare describe|dobj|pharmacokinetics pharmacokinetics|nmod|END_ENTITY	OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty .
7594101	1	11-amino_acid	455,468	Fab	377,380	11-amino acid	Fab	null	2187	Chemical	Gene	peptide|amod|START_ENTITY adenosine_diphosphate|conj|peptide compare|nmod|adenosine_diphosphate describe|conj|compare describe|dobj|pharmacokinetics pharmacokinetics|nmod|Fab END_ENTITY|appos|Fab	OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty .
9852147	3	11-amino_acid	652,665	GalNAc-T2	587,596	11-amino acid	GalNAc-T2	null	2590	Chemical	Gene	epitope|amod|START_ENTITY protein|conj|epitope fused|nmod|protein N-acetylgalactosaminyltransferase-2|acl|fused N-acetylgalactosaminyltransferase-2|appos|END_ENTITY	To mark the Golgi in HeLa cells , we stably expressed the Golgi stack enzyme N-acetylgalactosaminyltransferase-2 -LRB- GalNAc-T2 -RRB- fused to the green fluorescent protein -LRB- GFP -RRB- or to an 11-amino_acid epitope , VSV-G -LRB- VSV -RRB- , and the trans/TGN enzyme beta1,4-galactosyltransferase -LRB- GalT -RRB- fused to GFP .
11350667	4	11-amino_acid	630,643	gp120	680,685	11-amino acid	gp120	null	3700	Chemical	Gene	C4|amod|START_ENTITY antibodies|nmod|C4 peptide|nsubj|antibodies peptide|dep|recognize recognize|dobj|END_ENTITY	Rabbit antibodies to the 11-amino_acid linear C4 peptide did not recognize gp120 in the free state or when bound to CD4 .
9746776	9	11-amino_acid	1517,1530	GPIbalpha	1425,1434	11-amino acid	GPIbalpha	MESH:D000596	2811	Chemical	Gene	region|amod|START_ENTITY binds|nmod|region shown|ccomp|binds shown|advcl|Using Using|dobj|proteases proteases|acl:relcl|cleave cleave|dobj|END_ENTITY	Using proteases which cleave GPIbalpha at specific sites , we have shown that the GPIbalpha-specific antibody binds to an 11-amino_acid -LRB- 283 to 293 -RRB- region .
24444493	2	11-amino_acid	313,326	HSP27	371,376	11-amino acid	HSP27	null	3315	Chemical	Gene	YGRKKRRQRRR|amod|START_ENTITY domain|nmod|YGRKKRRQRRR tagged|nsubjpass|domain tagged|nmod|N-terminus N-terminus|nmod|END_ENTITY	The protein transduction domain -LRB- PTD -RRB- of the 11-amino_acid YGRKKRRQRRR was tagged at the N-terminus of HSP27 .
1621096	4	11-amino_acid	610,623	IF-2	589,593	11-amino acid	IF-2	null	9669	Chemical	Gene	insert|amod|START_ENTITY lacked|dobj|insert lacked|nsubj|genes genes|acl|encoding encoding|dobj|EF-2 EF-2|conj|END_ENTITY	The related -LRB- paralogous -RRB- genes encoding elongation factor EF-2 and initiation factor IF-2 also lacked the 11-amino_acid insert .
10793272	3	11-amino_acid	563,576	IGF-I	540,545	11-amino acid	IGF-I	null	3479	Chemical	Gene	epitope-tag|dep|START_ENTITY containing|dobj|epitope-tag END_ENTITY|xcomp|containing	Expression vectors were created that encoded porcine IGF-I containing a T7 -LRB- 11-amino_acid -RRB- epitope-tag -LRB- TIGF -RRB- .
10202013	0	11-amino_acid	3,16	I_kappa_B_alpha	167,182	11-amino acid	I kappa B alpha	MESH:D000596	18035(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|conj|phosphorylation phosphorylation|nmod|END_ENTITY	An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest .
12763940	5	11-amino_acid	650,663	IKKbeta	745,752	11-amino acid	IKKbeta	MESH:D000596	3551	Chemical	Gene	domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|IKKgamma IKKgamma|dep|interaction interaction|compound|END_ENTITY	We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation .
12763940	5	11-amino_acid	650,663	IKKgamma	729,737	11-amino acid	IKKgamma	MESH:D000596	8517	Chemical	Gene	domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|END_ENTITY	We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation .
8420968	2	11-amino_acid	369,382	LAMP-1	462,468	11-amino acid	LAMP-1	null	3916	Chemical	Gene	tail|amod|START_ENTITY terminus|nmod|tail residue|nmod|terminus constitutes|nsubj|residue constitutes|dobj|signal signal|nmod|END_ENTITY	Mutagenesis and transfection experiments indicate that the motif Tyr-X-X-hydrophobic residue at the carboxyl terminus of the 11-amino_acid cytoplasmic tail of the protein constitutes the lysosomal targeting signal for LAMP-1 .
10202013	0	11-amino_acid	3,16	MAPKAP_kinase-2	131,146	11-amino acid	MAPKAP kinase-2	MESH:D000596	17164(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sufficient|nsubj|sequence sufficient|nmod|activation activation|conj|activation activation|nmod|END_ENTITY	An 11-amino_acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun_N-terminal_kinase , activation of MAPKAP_kinase-2 , phosphorylation of I_kappa_B_alpha , and protection of WEHI-231 cells from anti-IgM-induced growth_arrest .
7962070	8	11-amino_acid	1344,1357	MDGI	1311,1315	11-amino acid	MDGI	MESH:D000596	14077(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY mimicked|nmod|sequence mimicked|nsubj|properties properties|nmod|END_ENTITY	Finally , the regulatory properties of MDGI can be fully mimicked by an 11-amino_acid sequence , represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs .
7962070	8	11-amino_acid	1344,1357	MDGI	1404,1408	11-amino acid	MDGI	MESH:D000596	14077(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|acl|represented represented|nmod|terminus terminus|nmod|END_ENTITY	Finally , the regulatory properties of MDGI can be fully mimicked by an 11-amino_acid sequence , represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs .
9852147	3	11-amino_acid	652,665	N-acetylgalactosaminyltransferase-2	550,585	11-amino acid	N-acetylgalactosaminyltransferase-2	null	79586	Chemical	Gene	epitope|amod|START_ENTITY protein|conj|epitope fused|nmod|protein END_ENTITY|acl|fused	To mark the Golgi in HeLa cells , we stably expressed the Golgi stack enzyme N-acetylgalactosaminyltransferase-2 -LRB- GalNAc-T2 -RRB- fused to the green fluorescent protein -LRB- GFP -RRB- or to an 11-amino_acid epitope , VSV-G -LRB- VSV -RRB- , and the trans/TGN enzyme beta1,4-galactosyltransferase -LRB- GalT -RRB- fused to GFP .
12763940	5	11-amino_acid	650,663	NEMO	739,743	11-amino acid	NEMO	MESH:D000596	8517	Chemical	Gene	domain|amod|START_ENTITY domain|acl:relcl|inhibits inhibits|dobj|IKKgamma IKKgamma|appos|END_ENTITY	We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation .
12763940	5	11-amino_acid	650,663	NF-kappaB	777,786	11-amino acid	NF-kappaB	MESH:D000596	4790	Chemical	Gene	domain|amod|START_ENTITY used|dobj|domain used|advcl|preventing preventing|dobj|activation activation|amod|END_ENTITY	We used an 11-amino_acid sequence NEMO-binding domain -LRB- NBD -RRB- that selectively inhibits the IKKgamma -LRB- NEMO -RRB- / IKKbeta interaction , preventing NF-kappaB activation .
22982609	2	11-amino_acid	435,448	PACAP	406,411	11-amino acid	PACAP	null	11516(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY tagging|nmod|domain tagging|dobj|END_ENTITY	In order to increase the efficiency of traversing biological barriers , a novel fusion peptide PACAP-TAT was produced by tagging PACAP at its C-terminus with 11-amino_acid TAT protein transduction domain .
14662773	11	11-amino_acid	1978,1991	profilin_I	2081,2091	11-amino acid	profilin I	MESH:D000596	5216	Chemical	Gene	motifs|amod|START_ENTITY motifs|acl:relcl|similar similar|nmod|site site|nmod|END_ENTITY	The actin binding activities of the B subunits of V-ATPase required 11-amino_acid actin-binding motifs that are similar in sequence to the actin-binding site of mammalian profilin_I .
14662773	5	11-amino_acid	1072,1085	profilin_I	1153,1163	11-amino acid	profilin I	MESH:D000596	5216	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|sequence sequence|amod|similar similar|nmod|site site|nmod|END_ENTITY	An 11-amino_acid segment with a sequence similar to the actin-binding site of human profilin_I was detected within this region .
11560935	6	11-amino_acid	947,960	Ras-GRF1	1107,1115	11-amino acid	Ras-GRF1	null	5923	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|domains domains|nmod|regions regions|dep|828-838 828-838|nmod|Sos1 Sos1|conj|1057-1067 1057-1067|nmod|END_ENTITY	Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors .
11560935	6	11-amino_acid	947,960	Ras-GRF1	882,890	11-amino acid	Ras-GRF1	null	5923	Chemical	Gene	segment|amod|START_ENTITY reside|nmod|segment revealed|ccomp|reside revealed|nsubj|Analysis Analysis|nmod|chimeras chimeras|conj|exchanges exchanges|nmod|Sos1 Sos1|conj|END_ENTITY	Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors .
11560935	6	11-amino_acid	947,960	Sos1	1085,1089	11-amino acid	Sos1	null	6654	Chemical	Gene	segment|amod|START_ENTITY segment|nmod|domains domains|nmod|regions regions|dep|828-838 828-838|nmod|END_ENTITY	Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors .
11560935	6	11-amino_acid	947,960	Sos1	873,877	11-amino acid	Sos1	null	6654	Chemical	Gene	segment|amod|START_ENTITY reside|nmod|segment revealed|ccomp|reside revealed|nsubj|Analysis Analysis|nmod|chimeras chimeras|conj|exchanges exchanges|nmod|END_ENTITY	Analysis of chimeras and individual amino_acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino_acids reside within an 11-amino_acid segment of their catalytic domains between the second and third structurally conserved regions -LRB- amino_acids -LRB- aa -RRB- 828-838 in Sos1 and 1057-1067 in Ras-GRF1 -RRB- of Ras guanine_nucleotide exchange factors .
7536738	2	11-amino_acid	414,427	substance_P	458,469	11-amino acid	substance P	null	21333(Tax:10090)	Chemical	Gene	D-Arg1|amod|START_ENTITY D-Arg1|appos|peptide peptide|compound|END_ENTITY	Incubation of Swiss_3T3 fibroblasts with the 11-amino_acid -LSB- D-Arg1 , D-Phe5 , D-Trp7 ,9 , Leu11 -RSB- substance_P peptide inhibited bombesin-stimulated cell proliferation and phospholipase C beta activation even at high bombesin concentrations .
18325388	1	11-amino_acid	86,99	Substance_P	63,74	11-amino acid	Substance P	MESH:D000596	21333(Tax:10090)	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|_ _|compound|END_ENTITY	BACKGROUND _ AIMS : Substance_P _ -LRB- SP -RRB- is an 11-amino_acid peptide that belongs to the tachykinin family of peptides .
8342042	4	11-amino_acid	580,593	TAP1	513,517	11-amino acid	TAP1	MESH:D000596	6890	Chemical	Gene	peptide|amod|START_ENTITY delivery|nmod|peptide resulted|nmod|delivery resulted|nsubj|Expression Expression|nmod|END_ENTITY	Expression of TAP1 and TAP2 in a mutant cell line resulted in the delivery of an 11-amino_acid oligomer model peptide to the ER .
8342042	4	11-amino_acid	580,593	TAP2	522,526	11-amino acid	TAP2	MESH:D000596	6891	Chemical	Gene	peptide|amod|START_ENTITY delivery|nmod|peptide resulted|nmod|delivery resulted|nsubj|Expression Expression|nmod|TAP1 TAP1|conj|END_ENTITY	Expression of TAP1 and TAP2 in a mutant cell line resulted in the delivery of an 11-amino_acid oligomer model peptide to the ER .
16390270	2	11-amino_acid	416,429	Tat11	516,521	11-amino acid	Tat11	null	6741294(Tax:353154)	Chemical	Gene	peptide|amod|START_ENTITY peptide|nmod|domain domain|nmod|protein protein|appos|END_ENTITY	We have shown that fusion of TK to an 11-amino_acid peptide from the basic domain of the human_immunodeficiency_virus_type_1 Tat protein -LRB- Tat11 -RRB- imparts cell membrane-translocating ability to the enzyme and significantly increases its cytotoxic activity .
7594101	1	11-amino_acid	455,468	thrombin	469,477	11-amino acid	thrombin	null	2147	Chemical	Gene	peptide|amod|START_ENTITY peptide|amod|END_ENTITY	OBJECTIVES : This study sought to describe in detail the pharmacokinetics and pharmacodynamics of chimeric monoclonal 7E3 Fab -LRB- c7E3 Fab -RRB- and to compare platelet responses to adenosine_diphosphate -LRB- ADP -RRB- and the 11-amino_acid thrombin receptor-activating peptide -LRB- TRAP -LSB- SFLLRNPNDKY-NH2 -RSB- -RRB- in patients undergoing elective coronary angioplasty .
10893266	4	11-amino_acid	629,642	Tiam1	687,692	11-amino acid	Tiam1	null	7074	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|amino_acids amino_acids|nmod|END_ENTITY	Biochemical studies and deletion mutation analyses indicate that the 11-amino_acid sequence between amino_acids 717 and 727 of Tiam1 -LRB- -LRB- 717 -RRB- GEGTDAVKRS -LRB- 727 -RRB- L -RRB- is the ankyrin-binding domain .
11054635	5	11-amino_acid	733,746	TR_beta	802,809	11-amino acid	TR beta	null	6957	Chemical	Gene	deletion|amod|START_ENTITY had|nsubj|deletion had|dobj|potency potency|nmod|END_ENTITY	Previously , we found beta F451X with carboxyl -LRB- C -RRB- - terminal 11-amino_acid deletion had stronger silencing potency than wild-type TR_beta 1 and beta E449X with C-terminal 13-amino_acid deletion on a subset of TREs .
8393816	11	11-amino-acid	1709,1722	agrin	1768,1773	11-amino-acid	agrin	null	396538(Tax:9031)	Chemical	Gene	results|amod|START_ENTITY results|nmod|expression expression|nmod|transcripts transcripts|compound|END_ENTITY	Alternative splicing of both the 8 - and the 11-amino-acid exons results in expression of four distinct agrin transcripts in the ganglion .
7557400	3	11-amino-acid	731,744	alpha-tubulin	874,887	11-amino-acid	alpha-tubulin	null	10376	Chemical	Gene	sequence|amod|START_ENTITY correspond|nmod|sequence correspond|conj|recognised recognised|nmod|END_ENTITY	The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin .
20345279	6	11-amino-acid	879,892	beta-glucuronidase	948,966	11-amino-acid	beta-glucuronidase	null	2990	Chemical	Gene	virus|amod|START_ENTITY virus|acl:relcl|fused fused|xcomp|END_ENTITY	Second , we used the 11-amino-acid human immunodeficiency virus -LRB- HIV -RRB- Tat domain fused to beta-glucuronidase to mediate uptake by absorptive endocytosis .
8690094	7	11-amino-acid	1047,1060	BPTI	947,951	11-amino-acid	BPTI	null	404103(Tax:9913)	Chemical	Gene	pVIc|amod|START_ENTITY complexed|nmod|pVIc proteinase|acl|complexed inhibitor|nmod|proteinase acts|nmod|inhibitor acts|nsubj|END_ENTITY	In vitro with purified components , BPTI acts as a competitive inhibitor -LRB- Ki 2 microM -RRB- of the recombinant proteinase complexed with its 11-amino-acid cofactor pVIc .
16600177	2	11-amino-acid	261,274	C4beta	370,376	11-amino-acid	C4beta	null	721	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|homology homology|nmod|sequence sequence|nmod|chain chain|amod|END_ENTITY	The C-terminal 11-amino-acid of the first CRIT-extracellular domain -LRB- CRIT-H17 -RRB- has a strong homology with a sequence in the C4beta chain , which is responsible for the binding of C2 .
12166660	2	11-amino-acid	350,363	CEL	289,292	11-amino-acid	CEL	null	1056	Chemical	Gene	motif|amod|START_ENTITY sequence|nmod|motif contain|dobj|sequence contain|nsubj|END_ENTITY	The gene encoding CEL was known to contain a tandemly repeated sequence of the 11-amino-acid motif in the C-terminal region .
8380082	4	11-amino-acid	674,687	CLP	620,623	11-amino-acid	CLP	null	810	Chemical	Gene	sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant prevented|dobj|formation formation|compound|END_ENTITY	Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation .
10485712	5	11-amino-acid	896,909	ClpA	796,800	11-amino-acid	ClpA	null	50945	Chemical	Gene	recognition|amod|START_ENTITY added|dobj|recognition stable|advcl|added peptide|amod|stable test|nmod|peptide test|dobj|action action|nmod|END_ENTITY	Here we test the action of ClpA on a stable monomeric protein , the green fluorescent protein GFP , onto which has been added an 11-amino-acid carboxy-terminal recognition peptide , which is responsible for recruiting truncated proteins to ClpAP for degradation .
7557400	3	11-amino-acid	731,744	c-myc	765,770	11-amino-acid	c-myc	null	4609	Chemical	Gene	sequence|amod|START_ENTITY correspond|nmod|sequence correspond|nmod|END_ENTITY	The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin .
9714840	4	11-amino-acid	548,561	Cre	494,497	11-amino-acid	Cre	null	2777477(Tax:10678)	Chemical	Gene	epitope_to_the_herpes_simplex_virus|amod|START_ENTITY terminus|nmod|epitope_to_the_herpes_simplex_virus 1989|amod|terminus tagged|nmod|1989 tagged|nsubjpass|protein protein|compound|END_ENTITY	We have constructed an expression vector wherein the Cre protein is tagged at the carboxy terminus with an 11-amino-acid epitope_to_the_herpes_simplex_virus -LRB- HSV -RRB- glycoprotein D coat protein -LRB- Isola , V.J. , Eisenberg , R.J. , Siebert , G.R. , Heilman , C.J. , Wilcox , W.C. , Cohan , G.H. , 1989 .
19451286	7	11-amino-acid	1170,1183	CyPA	1237,1241	11-amino-acid	CyPA	null	5478	Chemical	Gene	peptide|amod|START_ENTITY peptide|acl|known known|xcomp|block block|dobj|activity activity|nmod|END_ENTITY	Furthermore , antiviral experiments demonstrated that cyclosporine -LRB- Cs ; an 11-amino-acid cyclic peptide known to block the PPIase activity of CyPA -RRB- inhibits flavivirus replication in cell culture at nontoxic concentrations .
15823096	10	11-amino-acid	1384,1397	ed1	1331,1334	11-amino-acid	ed1	null	1896	Chemical	Gene	fragment|amod|START_ENTITY vWFA|nmod|fragment vWFA|acl|bound bound|dobj|peptide peptide|amod|END_ENTITY	vWFA bound the ed1 peptide of CRIT as well , and specifically to the 11-amino-acid peptide fragment of ed1 that is known to interact with whole C2 .
15823096	10	11-amino-acid	1384,1397	ed1	1418,1421	11-amino-acid	ed1	null	1896	Chemical	Gene	fragment|amod|START_ENTITY vWFA|nmod|fragment vWFA|nmod|END_ENTITY	vWFA bound the ed1 peptide of CRIT as well , and specifically to the 11-amino-acid peptide fragment of ed1 that is known to interact with whole C2 .
27577911	1	11-amino-acid	241,254	endostatin	294,304	11-amino-acid	endostatin	null	564123(Tax:7955)	Chemical	Gene	peptide|amod|START_ENTITY peptide|acl|derived derived|nmod|terminus terminus|nmod|END_ENTITY	Soluble O - -LRB- 2-hydroxyl -RRB- propyl-3-trimethyl_ammonium_chitooligosaccharide_chloride -LRB- HTCOSC -RRB- was covalently conjugated to the 11-amino-acid peptide derived from amino terminus of endostatin -LRB- endostatin2 , ES2 , IVRRADRAAVP -RRB- to overcome its poor stability , low cell affinity and instable activity .
9506920	2	11-amino-acid	404,417	FPR	321,324	11-amino-acid	FPR	null	2357	Chemical	Gene	corresponding|amod|START_ENTITY directed|nmod|corresponding antiserum|acl|directed produced|nsubjpass|antiserum cloned|conj|produced cloned|nsubjpass|cDNA cDNA|nmod|END_ENTITY	The cDNA for human FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptide corresponding to the deduced carboxy-terminus has been produced .
15994797	6	11-amino-acid	1063,1076	Gag	1118,1121	11-amino-acid	Gag	null	1491923(Tax:11886)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	One exception was the 11-amino-acid p2b sequence of Rous_sarcoma_virus _ -LRB- RSV -RRB- Gag , which could fully restore HIV-1 budding , while a PPPPY sequence exchange alone did not .
24406899	2	11-amino-acid	457,470	GDNF	314,318	11-amino-acid	GDNF	null	2668	Chemical	Gene	peptide|amod|START_ENTITY smaller|nmod|peptide formation|nmod|smaller theorizes|dobj|formation theorizes|nsubj|model model|nmod|proprotein proprotein|compound|END_ENTITY	A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller , amidated peptide -LRB- s -RRB- from the proregion that exhibit neurobiological function , including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 -LRB- DNSP-11 -RRB- .
14500468	1	11-amino-acid	213,226	glycoprotein_D	238,252	11-amino-acid	glycoprotein D	null	2532	Chemical	Gene	peptide|amod|START_ENTITY peptide|nmod|END_ENTITY	The potential of the major structural protein DraE of Escherichia_coli Dr fimbriae has been used to display an 11-amino-acid peptide of glycoprotein_D derived from herpes_simplex_virus -LRB- HSV -RRB- type 1 .
14500468	2	11-amino-acid	436,449	glycoprotein_D	353,367	11-amino-acid	glycoprotein D	null	2532	Chemical	Gene	sequence|amod|START_ENTITY place|nmod|sequence gene|nmod|place inserted|nmod|gene inserted|nsubjpass|sequence sequence|acl|mimicking mimicking|nmod|END_ENTITY	The heterologous sequence mimicking an epitope from glycoprotein_D was inserted in one copy into the draE gene in place of a predicted 11-amino-acid sequence in the N-terminal region of surface-exposed domain 2 within the conserved disulfide loop -LRB- from Cys21 to Cys53 -RRB- .
14500468	4	11-amino-acid	899,912	glycoprotein_D	928,942	11-amino-acid	glycoprotein D	null	2532	Chemical	Gene	epitope|amod|START_ENTITY END_ENTITY|nsubj|epitope	Conversely , immunization of rabbits with purified chimeric Dr-HSV fimbriae resulted in a serum that specifically recognized the 11-amino-acid epitope of HSV glycoprotein_D , indicating the utility of the strategy employed .
14693913	4	11-amino-acid	888,901	hBSSL	862,867	11-amino-acid	hBSSL	null	1056	Chemical	Gene	repeats|amod|START_ENTITY contain|dobj|repeats contain|nsubj|residues residues|nmod|END_ENTITY	The C-terminal 192 residues of hBSSL contain 16 Pro-rich 11-amino-acid repeats , which include 32 Ser/Thr residues as potential O-glycosylation sites .
28125988	4	11-amino-acid	402,415	hepatocyte_growth_factor	436,460	11-amino-acid	hepatocyte growth factor	null	24446(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|END_ENTITY	We identified an 11-amino-acid peptide , H-RN , from hepatocyte_growth_factor -LRB- HGF -RRB- , an endogenous protein with anti-inflammatory properties .
28125988	4	11-amino-acid	402,415	HGF	462,465	11-amino-acid	HGF	null	24446(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|hepatocyte_growth_factor hepatocyte_growth_factor|appos|END_ENTITY	We identified an 11-amino-acid peptide , H-RN , from hepatocyte_growth_factor -LRB- HGF -RRB- , an endogenous protein with anti-inflammatory properties .
26191773	3	11-amino-acid	532,545	IkBa	607,611	11-amino-acid	IkBa	null	4792	Chemical	Gene	sequence|amod|START_ENTITY sequence|acl:relcl|sufficient sufficient|conj|required required|nmod|half-life half-life|nmod:poss|END_ENTITY	The ubiquitin-independent degradation signal resides in an 11-amino-acid sequence , which is not only sufficient but also required for IkBa 's short half-life .
9811606	6	11-amino-acid	1167,1180	interleukin-2_receptor_alpha	1130,1158	11-amino-acid	interleukin-2 receptor alpha	null	3559	Chemical	Gene	region|amod|START_ENTITY END_ENTITY|nmod|region	This motif acts as an internalization signal in the context of a CD8-Nef chimera or in a fusion of the interleukin-2_receptor_alpha with an 11-amino-acid region from Nef containing the dileucine motif .
9513711	9	11-amino-acid	1370,1383	MDGI	1409,1413	11-amino-acid	MDGI	null	14077(Tax:10090)	Chemical	Gene	peptide|amod|START_ENTITY mimic|nsubj|peptide mimic|dobj|activity activity|compound|END_ENTITY	An MDGI-derived C-terminal 11-amino-acid peptide is able to mimic MDGI activity in vitro .
9811606	6	11-amino-acid	1167,1180	Nef	1193,1196	11-amino-acid	Nef	null	156110(Tax:11676)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	This motif acts as an internalization signal in the context of a CD8-Nef chimera or in a fusion of the interleukin-2_receptor_alpha with an 11-amino-acid region from Nef containing the dileucine motif .
7856096	4	11-amino-acid	429,442	ORF1	402,406	11-amino-acid	ORF1	null	55354	Chemical	Gene	epitope|amod|START_ENTITY inserted|nsubjpass|epitope inserted|advcl|determine determine|ccomp|encodes encodes|nsubj|END_ENTITY	To determine whether ORF1 encodes a protein , an 11-amino-acid epitope was inserted in frame after the ninth codon of the ORF1 open reading frame .
7856096	4	11-amino-acid	429,442	ORF1	502,506	11-amino-acid	ORF1	null	55354	Chemical	Gene	epitope|amod|START_ENTITY inserted|nsubjpass|epitope inserted|nmod|codon codon|nmod|frame frame|compound|END_ENTITY	To determine whether ORF1 encodes a protein , an 11-amino-acid epitope was inserted in frame after the ninth codon of the ORF1 open reading frame .
27707926	15	11-amino-acid	2205,2218	p12	2163,2166	11-amino-acid	p12	null	69745(Tax:10090)	Chemical	Gene	motif|amod|START_ENTITY identified|nmod|motif identified|nsubjpass|tethering tethering|amod|END_ENTITY	Maximal p12 tethering was identified with only an 11-amino-acid minimal chromatin tethering motif encoded at p1261-71 Within this region , the p12-M63I substitution switches p12 into a tethering-competent state , partially rescuing the p12-PM15 tethering mutant .
27707926	15	11-amino-acid	2205,2218	p12	2328,2331	11-amino-acid	p12	null	69745(Tax:10090)	Chemical	Gene	motif|amod|START_ENTITY motif|acl|encoded encoded|nmod|p1261-71 p1261-71|acl:relcl|switches switches|dobj|END_ENTITY	Maximal p12 tethering was identified with only an 11-amino-acid minimal chromatin tethering motif encoded at p1261-71 Within this region , the p12-M63I substitution switches p12 into a tethering-competent state , partially rescuing the p12-PM15 tethering mutant .
9510558	6	11-amino-acid	1019,1032	p193	1068,1072	11-amino-acid	p193	null	143	Chemical	Gene	sequence|amod|START_ENTITY induced|ccomp|sequence induced|conj|located located|nmod|END_ENTITY	The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 - 203 -LRB- E-I-W-R-D-I-D-F-A-H-E -RRB- .
23652276	3	11-amino-acid	450,463	P2_and_P4	515,524	11-amino-acid	P2 and P4	null	201780	Chemical	Gene	peptide|amod|START_ENTITY N-terminus|conj|peptide N-terminus|conj|two two|acl|designed designed|ccomp|generated generated|nsubjpass|peptides peptides|appos|END_ENTITY	In this study , Inhibitor2 , a heptapeptide MMP inhibitor , was connected to the N-terminus or C-terminus of ES-2 , an 11-amino-acid antiangiogenic peptide , and two designed peptides , P2_and_P4 , were generated .
2963808	4	11-amino-acid	512,525	P-450	581,586	11-amino-acid	P-450	null	1555	Chemical	Gene	sequence|amod|START_ENTITY human-2|nsubj|sequence human-2|nmod|agreement agreement|nmod|sequence sequence|nmod|END_ENTITY	The N-terminal 11-amino-acid sequence was in agreement with the protein sequence of P-450 human-2 .
17610503	3	11-amino-acid	887,900	p53	1047,1050	11-amino-acid	p53	null	7157	Chemical	Gene	region|amod|START_ENTITY fusion|nmod|region TAT|nsubj|fusion TAT|dep|increases increases|dobj|solubility solubility|nmod|protein protein|compound|END_ENTITY	Here , we show that fusion of an 11-amino-acid region of the human immunodeficiency virus TAT protein transduction domain -LRB- PTD -RRB- to human p53 increases the solubility of the otherwise insoluble p53 protein and this rTAT-p53 protein can be transduced into human monocyte-derived dendritic cells -LRB- DCs -RRB- .
17610503	3	11-amino-acid	887,900	p53	991,994	11-amino-acid	p53	null	7157	Chemical	Gene	region|amod|START_ENTITY fusion|nmod|region TAT|nsubj|fusion TAT|dep|increases increases|nsubj|domain domain|nmod|END_ENTITY	Here , we show that fusion of an 11-amino-acid region of the human immunodeficiency virus TAT protein transduction domain -LRB- PTD -RRB- to human p53 increases the solubility of the otherwise insoluble p53 protein and this rTAT-p53 protein can be transduced into human monocyte-derived dendritic cells -LRB- DCs -RRB- .
8384581	3	11-amino-acid	540,553	PP-1_alpha	451,461	11-amino-acid	PP-1 alpha	null	5499	Chemical	Gene	insert|amod|START_ENTITY PP-1_alpha|nmod|insert differs|nmod|PP-1_alpha subunit|acl:relcl|differs subunit|dep|2 2|compound|END_ENTITY	One clone encodes a novel type 1 protein phosphatase catalytic subunit -LRB- PP-1_alpha 2 -RRB- , which differs from the originally defined PP-1_alpha by an amino-terminal 11-amino-acid insert .
8384581	3	11-amino-acid	540,553	PP-1_alpha	508,518	11-amino-acid	PP-1 alpha	null	5499	Chemical	Gene	insert|amod|START_ENTITY END_ENTITY|nmod|insert	One clone encodes a novel type 1 protein phosphatase catalytic subunit -LRB- PP-1_alpha 2 -RRB- , which differs from the originally defined PP-1_alpha by an amino-terminal 11-amino-acid insert .
8690094	7	11-amino-acid	1047,1060	proteinase	1017,1027	11-amino-acid	proteinase	null	100862683	Chemical	Gene	pVIc|amod|START_ENTITY complexed|nmod|pVIc END_ENTITY|acl|complexed	In vitro with purified components , BPTI acts as a competitive inhibitor -LRB- Ki 2 microM -RRB- of the recombinant proteinase complexed with its 11-amino-acid cofactor pVIc .
18705864	8	11-amino-acid	1268,1281	RPP13	1310,1315	11-amino-acid	RPP13	null	823806(Tax:3702)	Chemical	Gene	units|amod|START_ENTITY variation|nmod|units affect|nsubj|variation affect|dobj|recognition recognition|compound|END_ENTITY	The extensive variation in the 11-amino-acid repeat units did not affect RPP13 recognition .
9651500	3	11-amino-acid	604,617	sTnT	587,591	11-amino-acid	sTnT	null	7138	Chemical	Gene	segment|amod|START_ENTITY encoding|dobj|segment found|xcomp|encoding found|nmod|END_ENTITY	Together with a 5 ' - alternative exon that was also found in human sTnT encoding an 11-amino-acid acidic segment , the results revealed a novel alternative splicing pathway to include or exclude a three-base segment to generate additional sTnT isoforms with NH2-terminal charge variations .
9651500	3	11-amino-acid	604,617	sTnT	758,762	11-amino-acid	sTnT	null	7138	Chemical	Gene	segment|amod|START_ENTITY encoding|dobj|segment found|xcomp|encoding exon|acl:relcl|found 5|dep|exon Together|nmod|5 revealed|advmod|Together revealed|dobj|alternative alternative|acl|splicing splicing|xcomp|include include|advcl|generate generate|dobj|isoforms isoforms|compound|END_ENTITY	Together with a 5 ' - alternative exon that was also found in human sTnT encoding an 11-amino-acid acidic segment , the results revealed a novel alternative splicing pathway to include or exclude a three-base segment to generate additional sTnT isoforms with NH2-terminal charge variations .
22210023	2	11-amino-acid	378,391	substance-P	357,368	11-amino-acid	substance-P	null	6863	Chemical	Gene	peptide|amod|START_ENTITY _|appos|peptide _|amod|END_ENTITY	In this report , we introduce a novel function of substance-P _ -LRB- SP -RRB- , an 11-amino-acid peptide , as an injury-inducible messenger to mobilize bone marrow stem cells to the blood and finally to engage in tissue repair .
1696081	1	11-amino-acid	69,82	Substance_P	46,57	11-amino-acid	Substance P	null	6863	Chemical	Gene	neuropeptide|amod|START_ENTITY neuropeptide|nsubj|_ _|compound|END_ENTITY	Substance_P _ -LRB- SP -RRB- is an 11-amino-acid neuropeptide found in sensory neurons in the peripheral nervous system .
9436358	4	11-amino-acid	670,683	Substance_P	616,627	11-amino-acid	Substance P	null	6863	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY	Substance_P , a member of the tachykinin family , is an 11-amino-acid peptide .
12489030	3	11-amino-acid	487,500	Tat11	557,562	11-amino-acid	Tat11	null	6741294(Tax:353154)	Chemical	Gene	peptide|amod|START_ENTITY TK|nmod|peptide fusion|nmod|TK imparts|nsubj|fusion imparts|dep|END_ENTITY	Here we report that fusion of TK to an 11-amino-acid peptide from the basic domain of the HIV-1 Tat protein -LRB- Tat11 -RRB- imparts cell membrane translocating ability to the enzyme and significantly increases its cytotoxic efficacy .
7935437	7	11-amino-acid	1145,1158	TATA-binding_protein	1209,1229	11-amino-acid	TATA-binding protein	null	6908	Chemical	Gene	module|amod|START_ENTITY forms|nmod|module bound|nsubj|forms bound|nmod|TFIIB TFIIB|conj|END_ENTITY	While dimeric forms of the 11-amino-acid acidic activation module bound to either TFIIB or TATA-binding_protein efficiently in vitro , a similarly charged peptide lacking the core phenylalanine residue failed to interact .
12489030	0	11-amino-acid	71,84	thymidine_kinase	39,55	11-amino-acid	thymidine kinase	null	24271467	Chemical	Gene	peptide|amod|START_ENTITY mediated|nmod|peptide mediated|nsubj|transfer transfer|nmod|END_ENTITY	Transcellular transfer of active HSV-1 thymidine_kinase mediated by an 11-amino-acid peptide from HIV-1 Tat .
9596755	2	11-amino-acid	312,325	TNF	274,277	11-amino-acid	TNF	null	21926(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY consisting|nmod|site peptide|acl|consisting peptide|compound|END_ENTITY	Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically .
9596755	2	11-amino-acid	312,325	TNF	326,329	11-amino-acid	TNF	null	21926(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY site|compound|END_ENTITY	Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically .
9596755	2	11-amino-acid	312,325	TNF	427,430	11-amino-acid	TNF	null	21926(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY consisting|nmod|site peptide|acl|consisting possess|nsubj|peptide possess|dobj|many many|nmod|properties properties|nmod|END_ENTITY	Recently , a TNF agonist peptide consisting of the 11-amino-acid TNF binding site -LRB- TNF70-80 -RRB- has been shown to possess many of the leukocyte-activating properties of TNF without the associated toxicity when administered locally or systemically .
9510558	6	11-amino-acid	1019,1032	tyrosinase	1057,1067	11-amino-acid	tyrosinase	null	7299	Chemical	Gene	sequence|amod|START_ENTITY induced|ccomp|sequence induced|conj|located located|nmod|p193 p193|amod|END_ENTITY	The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 - 203 -LRB- E-I-W-R-D-I-D-F-A-H-E -RRB- .
19099499	4	11-amino-acid	653,666	U11	682,685	11-amino-acid	U11	null	26824	Chemical	Gene	sequence|amod|START_ENTITY sequence|acl|named named|dobj|peptide peptide|nummod|END_ENTITY	Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle .
19099499	4	11-amino-acid	653,666	U11	734,737	11-amino-acid	U11	null	26824	Chemical	Gene	sequence|amod|START_ENTITY sequence|acl|named named|dobj|peptide peptide|acl|modified modified|xcomp|form form|xcomp|peptide-lipid peptide-lipid|nsubj|amphiphile.This amphiphile.This|nummod|END_ENTITY	Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle .
19099499	4	11-amino-acid	653,666	U11	877,880	11-amino-acid	U11	null	26824	Chemical	Gene	sequence|amod|START_ENTITY consisting|nmod|sequence ligand|xcomp|consisting targeting|dep|ligand uPAR|acl|targeting synthesis|nmod|uPAR derive|nsubj|synthesis derive|dobj|nanoparticle nanoparticle|compound|END_ENTITY	Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle .
19680632	1	11-amino-acid	104,117	U-II	92,96	11-amino-acid	U-II	null	10911	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|urotensin-II urotensin-II|appos|END_ENTITY	Human urotensin-II -LRB- U-II -RRB- is an 11-amino-acid cyclic peptide that activates a G -LRB- q -RRB- - coupled receptor named UT .
19099499	4	11-amino-acid	653,666	uPAR	614,618	11-amino-acid	uPAR	null	5329	Chemical	Gene	sequence|amod|START_ENTITY consisting|nmod|sequence ligand|xcomp|consisting targeting|dep|ligand END_ENTITY|acl|targeting	Here , we describe the synthesis of a novel uPAR targeting ligand consisting of an 11-amino-acid sequence named U11 peptide modified with an alkyl chain to form an U11 peptide-lipid amphiphile.This peptide-lipid is inserted into the outer layer of a parent stealth liposome by post-modification to derive a U11 peptide-targeted nanoparticle .
19680632	1	11-amino-acid	104,117	urotensin-II	78,90	11-amino-acid	urotensin-II	null	10911	Chemical	Gene	peptide|amod|START_ENTITY peptide|nsubj|END_ENTITY	Human urotensin-II -LRB- U-II -RRB- is an 11-amino-acid cyclic peptide that activates a G -LRB- q -RRB- - coupled receptor named UT .
8380082	4	11-amino-acid	674,687	VP7	589,592	11-amino-acid	VP7	null	2943155(Tax:40051)	Chemical	Gene	sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant terminus|acl|prevented terminus|nummod|END_ENTITY	Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation .
8380082	4	11-amino-acid	674,687	VP7	741,744	11-amino-acid	VP7	null	2943155(Tax:40051)	Chemical	Gene	sequence|amod|START_ENTITY involving|dobj|sequence mutant|xcomp|involving prevented|advcl|mutant terminus|acl|prevented mutants|nmod|terminus added|nsubj|mutants added|nmod|terminus terminus|nmod|formation formation|nummod|END_ENTITY	Deletion and extension mutants involving the VP7 carboxy terminus prevented CLP formation , while an extension mutant involving an 11-amino-acid rabies_virus sequence added to the amino terminus of VP7 allowed CLP formation .
7557400	3	11-amino-acid	731,744	YL1/2	865,870	11-amino-acid	YL1/2	null	6944	Chemical	Gene	sequence|amod|START_ENTITY correspond|nmod|sequence correspond|conj|recognised recognised|nmod|END_ENTITY	The epitope tags correspond to an 11-amino-acid sequence from human c-myc , recognised by monoclonal antibody -LRB- mAb -RRB- 9E10 , and the Glu-Glu-Phe sequence recognised by mAb YL1/2 to alpha-tubulin .
19035465	4	11-amino_acid_peptide	475,496	KV11	504,508	11-amino acid peptide	KV11	MESH:D000602	3736	Chemical	Gene	START_ENTITY|dep|named named|dobj|END_ENTITY	Here , we identified an 11-amino_acid_peptide -LRB- named KV11 -RRB- as the key region for the antiangiogenic function of the KV domain of apolipoprotein -LRB- a -RRB- .
14769036	3	11-amino_acid_peptide	543,564	PKB	631,634	11-amino acid peptide	PKB	MESH:D000602	2185	Chemical	Gene	was|nsubj|START_ENTITY was|advmod|efficiently efficiently|dep|phosphorylated phosphorylated|nmod|protein_kinase_B protein_kinase_B|appos|END_ENTITY	We utilized a quantitative , single-cell assay to demonstrate that an 11-amino_acid_peptide was efficiently phosphorylated by intracellular protein_kinase_B -LRB- PKB -RRB- in fibrosarcoma cell line HT1080 and in NIH-3T3 cells .
14769036	3	11-amino_acid_peptide	543,564	protein_kinase_B	613,629	11-amino acid peptide	protein kinase B	MESH:D000602	2185	Chemical	Gene	was|nsubj|START_ENTITY was|advmod|efficiently efficiently|dep|phosphorylated phosphorylated|nmod|END_ENTITY	We utilized a quantitative , single-cell assay to demonstrate that an 11-amino_acid_peptide was efficiently phosphorylated by intracellular protein_kinase_B -LRB- PKB -RRB- in fibrosarcoma cell line HT1080 and in NIH-3T3 cells .
12966076	3	11-amino_acid_peptide	868,889	rhodopsin	1037,1046	11-amino acid peptide	rhodopsin	MESH:D000602	6010	Chemical	Gene	START_ENTITY|nmod|alpha-subunit alpha-subunit|nmod|Gt Gt|acl|suggesting suggesting|ccomp|plays plays|nmod|interaction interaction|nmod|intermediates intermediates|compound|END_ENTITY	Here we demonstrate that the interactions of Gt with these intermediates in the absence of GTPgammaS can be mimicked by the C-terminus 11-amino_acid_peptide -LRB- 340-350 -RRB- of the alpha-subunit of Gt -LRB- Gt -LRB- alpha -RRB- -RRB- , suggesting that the C-terminal region of Gt -LRB- alpha -RRB- plays important roles in the interaction with rhodopsin intermediates .
8487866	6	11-amino-acid_peptide	886,907	rhodopsin	984,993	11-amino-acid peptide	rhodopsin	MESH:D000602	6010	Chemical	Gene	terminus|amod|START_ENTITY END_ENTITY|nsubj|terminus	An 11-amino-acid_peptide from the C terminus of the alpha-subunit of Gt -LRB- alpha t -LRB- 340-350 -RRB- -RRB- binds to rhodopsin and mimics the G protein in stabilizing its active form , metarhodopsin_II .
25446075	3	11-amino-acids	618,632	Pak1	665,669	11-amino-acids	Pak1	null	18479(Tax:10090)	Chemical	Gene	peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|domain domain|nmod|END_ENTITY	Here , we identified 11-amino-acids peptide within kinase domain of Pak1 , necessary and sufficient for SKIP binding .
25446075	3	11-amino-acids	618,632	SKIP	700,704	11-amino-acids	SKIP	null	19062(Tax:10090)	Chemical	Gene	peptide|amod|START_ENTITY identified|dobj|peptide identified|nmod|binding binding|compound|END_ENTITY	Here , we identified 11-amino-acids peptide within kinase domain of Pak1 , necessary and sufficient for SKIP binding .
10482456	3	11-aminobenzoquinolizidines	440,467	acetylcholinesterase	396,416	11-aminobenzoquinolizidines	acetylcholinesterase	null	43	Chemical	Gene	employing|xcomp|START_ENTITY produce|advcl|employing produce|dobj|inhibitor inhibitor|amod|END_ENTITY	The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines -LRB- 4 -RRB- and 10-aminobenzoindolizidines -LRB- 5 -RRB- as templates .
12868745	0	11-aminoundecanethiol	78,99	glucose_oxidase	39,54	11-aminoundecanethiol	glucose oxidase	null	54363	Chemical	Gene	monolayers|amod|START_ENTITY attached|nmod|monolayers attached|nsubj|formation formation|nmod|covalently covalently|amod|END_ENTITY	Self-assembling monolayer formation of glucose_oxidase covalently attached on 11-aminoundecanethiol monolayers on gold .
27035762	2	11-aminoundecanoic_acid	427,450	CD_1a	561,566	11-aminoundecanoic acid	CD 1a	MESH:C023820	909	Chemical	Gene	Na-salt|advcl|START_ENTITY glycine|conj|Na-salt Na-salt|acl|glycine produce|nsubj|Na-salt produce|dobj|1s 1s|conj|END_ENTITY	Citric_acid was used as the source of the carbon core , and Na-salt of glycine , glycine , Na-salt of 11-aminoundecanoic_acid , 11-aminoundecanoic_acid , and n-hexadecylamine were used for the surface fabrication of CDs to produce CD 1s , CD_1a , CD_2s , CD_2a , and CD 3 , respectively .
27035762	2	11-aminoundecanoic_acid	452,475	CD_1a	561,566	11-aminoundecanoic acid	CD 1a	MESH:C023820	909	Chemical	Gene	glycine|conj|START_ENTITY Na-salt|acl|glycine produce|nsubj|Na-salt produce|dobj|1s 1s|conj|END_ENTITY	Citric_acid was used as the source of the carbon core , and Na-salt of glycine , glycine , Na-salt of 11-aminoundecanoic_acid , 11-aminoundecanoic_acid , and n-hexadecylamine were used for the surface fabrication of CDs to produce CD 1s , CD_1a , CD_2s , CD_2a , and CD 3 , respectively .
27634443	3	11-amnio_acid	451,464	EPO	521,524	11-amnio acid	EPO	null	2056	Chemical	Gene	sequence|amod|START_ENTITY sequence|acl|derived derived|nmod|B B|nmod|END_ENTITY	Helix B surface peptide -LRB- HBSP -RRB- , a 11-amnio_acid sequence derived from the non-erythropoietic helix B of EPO , not only shows higher affinity to TPR but also plays a more specific and powerful role in tissue protection without erythropoietic side-effects .
19052845	7	11Arg	947,952	ADAMTS9	884,891	11Arg	ADAMTS9	null	56999	Chemical	Gene	inhibitors|conj|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|expression expression|compound|END_ENTITY	The IL-1_beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors , FK506 and 11Arg -LRB- 11R -RRB- - VIVIT .
19052845	7	11Arg	947,952	IL-1_beta	864,873	11Arg	IL-1 beta	null	3553	Chemical	Gene	inhibitors|conj|START_ENTITY inhibited|nmod|inhibitors inhibited|nsubjpass|expression expression|amod|inducible inducible|amod|END_ENTITY	The IL-1_beta inducible ADAMTS9 expression was inhibited by NFAT inhibitors , FK506 and 11Arg -LRB- 11R -RRB- - VIVIT .
11301332	5	11-azidophenyl_agosterol_A	618,644	MRP1	751,755	11-azidophenyl agosterol A	MRP1	MESH:C429345	4363	Chemical	Gene	-RSB-|xcomp|START_ENTITY -RSB-|xcomp|photolabel photolabel|dobj|END_ENTITY	We synthesized -LSB- -LRB- 125 -RRB- I -RSB- 11-azidophenyl_agosterol_A -LRB- -LSB- -LRB- 125 -RRB- I -RSB- azidoAG-A -RRB- , a photoaffinity analog of the MDR-reversing agent , agosterol_A -LRB- AG-A -RRB- , to photolabel MRP1 , and found that the analog photolabeled the C-proximal molecule of MRP1 -LRB- C -LRB- 932-1531 -RRB- -RRB- in a manner that was GSH-dependent .
11301332	5	11-azidophenyl_agosterol_A	618,644	MRP1	823,827	11-azidophenyl agosterol A	MRP1	MESH:C429345	4363	Chemical	Gene	-RSB-|xcomp|START_ENTITY -LSB-|acl:relcl|-RSB- synthesized|dobj|-LSB- synthesized|conj|found found|ccomp|photolabeled photolabeled|dobj|molecule molecule|nmod|END_ENTITY	We synthesized -LSB- -LRB- 125 -RRB- I -RSB- 11-azidophenyl_agosterol_A -LRB- -LSB- -LRB- 125 -RRB- I -RSB- azidoAG-A -RRB- , a photoaffinity analog of the MDR-reversing agent , agosterol_A -LRB- AG-A -RRB- , to photolabel MRP1 , and found that the analog photolabeled the C-proximal molecule of MRP1 -LRB- C -LRB- 932-1531 -RRB- -RRB- in a manner that was GSH-dependent .
18255051	1	11-azidoundecyl_glycoside	152,177	GM1	261,264	11-azidoundecyl glycoside	GM1	null	210582(Tax:10090)	Chemical	Gene	undec-10-ynyl|conj|START_ENTITY analogues|amod|undec-10-ynyl analogues|amod|corresponding corresponding|dep|GM3 GM3|conj|END_ENTITY	Undec-10-enyl , _ undec-10-ynyl and 11-azidoundecyl_glycoside analogues corresponding to the oligosaccharides of human gangliosides GM3 , GM2 and GM1 were synthesized in high yields using glycosyltransferases from Campylobacter_jejuni .
8898974	3	11B	683,686	glutathione_S-transferase	873,898	11B	glutathione S-transferase	CHEBI:52451	373156	Chemical	Gene	UM-SCC|conj|START_ENTITY lines|dep|UM-SCC determined|nmod|lines determined|nsubjpass|5-fluorouracil 5-fluorouracil|conj|content content|nmod|END_ENTITY	In ten established head_and_neck_cancer cell lines -LRB- UM-SCC 10A , 10B , 11B , 14A , 14B , 14C , and 22B , HLac79 , 8029NA , and 8029DDP4 -RRB- chemosensitivity to cisplatin , carboplatin , 5-fluorouracil , and bleomycin , as well as cellular glutathione content and activity of glutathione_S-transferase were determined .
15770608	6	11B	1022,1025	spin_3	1010,1016	11B	spin 3	CHEBI:52451	169981	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Both 10B -LRB- spin_3 -RRB- and 11B -LRB- spin_3 / 2 -RRB- are quadrupolar nuclei , and their typical relaxation times , in common BNCT agents in biological environments , are rather short .
11703821	6	11B1	858,862	CD151	914,919	11B1	CD151	null	977	Chemical	Gene	reliable|nsubj|START_ENTITY reliable|nmod|detection detection|nmod|END_ENTITY	Of six monoclonal antibodies from four laboratories , 11B1 was found to be the most reliable for detection of CD151 in different cell and tissue contexts .
25204776	8	11B11	1259,1264	CD11b	1327,1332	11B11	CD11b	null	3684	Chemical	Gene	therapy|nmod|START_ENTITY therapy|conj|trastuzumab trastuzumab|acl|resulted resulted|nmod|reduction reduction|nmod|CD206 CD206|compound|END_ENTITY	Combination therapy with 11B11 and trastuzumab resulted in a reduction of tumor-infiltrating CD11b -LRB- + -RRB- CD206 -LRB- + -RRB- myeloid cells compared with monotherapy .
9168846	3	11B11	512,517	ovalbumin	548,557	11B11	ovalbumin	null	282665(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|conj|sensitized sensitized|nmod|saline saline|conj|END_ENTITY	Mice treated with 11B11 and sensitized with saline or ovalbumin had significantly less serum IgE than their respective control groups which were treated with saline -LRB- p < 0.05 -RRB- .
21321719	7	11B-11B	2011,2018	B-O-B	2055,2060	11B-11B	B-O-B	null	2838	Chemical	Gene	J|appos|START_ENTITY couplings|nsubj|J couplings|advcl|increasing increasing|dobj|angle angle|amod|END_ENTITY	First-principles calculations , using the GIPAW approach , of the -LRB- 2 -RRB- J -LRB- 11B-11B -RRB- couplings in lithium_diborate , metaborate and triborate are presented : a clear trend is revealed whereby the -LRB- 2 -RRB- J -LRB- 11B-11B -RRB- couplings increase with increasing B-O-B bond angle and B-B distance .
26658226	7	11b,18-diOH-OT	1419,1433	CYP11B	1366,1372	11b,18-diOH-OT	CYP11B	null	1584	Chemical	Gene	resonance|amod|START_ENTITY resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|nummod|END_ENTITY	They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT .
26658226	7	11b,18-diOH-OT	1419,1433	CYP11B2	1391,1398	11b,18-diOH-OT	CYP11B2	null	1585	Chemical	Gene	resonance|amod|START_ENTITY resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|acl:relcl|formed formed|nsubj|END_ENTITY	They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT .
26658226	7	11b,18-expoxy-18-OH-OT	1495,1517	CYP11B	1366,1372	11b,18-expoxy-18-OH-OT	CYP11B	null	1584	Chemical	Gene	rearranges|nmod|START_ENTITY resonance|acl:relcl|rearranges resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|nummod|END_ENTITY	They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT .
26658226	7	11b,18-expoxy-18-OH-OT	1495,1517	CYP11B2	1391,1398	11b,18-expoxy-18-OH-OT	CYP11B2	null	1585	Chemical	Gene	rearranges|nmod|START_ENTITY resonance|acl:relcl|rearranges resonance|acl|11b-OH-OT 11b-OH-OT|nmod|isoforms isoforms|acl:relcl|formed formed|nsubj|END_ENTITY	They were identified by nuclear magnetic resonance spectroscopy to be 11b-OH-OT for both CYP11B isoforms , whereby CYP11B2 additionally formed 11b,18-diOH-OT and 11b-OH-OT-18-al , which rearranges to its tautomeric form 11b,18-expoxy-18-OH-OT .
9345900	0	11B2-B5	100,107	Acadvl	67,73	11B2-B5	Acadvl	null	11370(Tax:10090)	Chemical	Gene	band|nummod|START_ENTITY mouse|dobj|band mouse|nsubj|END_ENTITY	Assignment of the gene for very-long-chain acyl-CoA dehydrogenase -LRB- Acadvl -RRB- to mouse chromosome band 11B2-B5 by in situ hybridization .
18392045	5	11B5-C	719,725	TM2	741,744	11B5-C	TM2	null	22003(Tax:10090)	Chemical	Gene	regions|conj|START_ENTITY regions|acl:relcl|mapped mapped|nsubjpass|mutations mutations|compound|TM1 TM1|conj|END_ENTITY	We could not identify any known gene that was implicated in a similar function in the chromosomal regions 7E-F1 and 11B5-C , where TM1 and TM2 mutations were mapped to respectively .
9194197	3	11B_amino_acids	545,560	myotrophin	530,540	11B amino acids	myotrophin	null	136319	Chemical	Gene	has|dobj|START_ENTITY has|nsubj|END_ENTITY	Recent cDNA cloning revealed that myotrophin has 11B_amino_acids containing 2.5 contiguous ANK repeats , a motif known to be involved in a wide range of macromolecular recognition .
24074876	0	11b-aminoprogesterone	35,56	mineralocorticoid_receptor	135,161	11b-aminoprogesterone	mineralocorticoid receptor	null	4306	Chemical	Gene	derivatives|amod|START_ENTITY encumbered|dobj|derivatives encumbered|nmod|inhibitors inhibitors|conj|antagonists antagonists|compound|END_ENTITY	Synthesis of sterically encumbered 11b-aminoprogesterone derivatives and evaluation as 11b-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid_receptor antagonists .
28514642	4	11b-deoxycortisol	915,932	CYP11B1	740,747	11b-deoxycortisol	CYP11B1	null	1584	Chemical	Gene	conversion|nmod|START_ENTITY %|nmod|conversion reduced|nmod|% revealed|ccomp|reduced demonstrated|conj|revealed demonstrated|ccomp|expressed expressed|nsubjpass|type type|nmod|END_ENTITY	In vitro expression studies , immunofluorescence demonstrated that wild type and mutant -LRB- L410R and G411C -RRB- proteins of CYP11B1 were correctly expressed on the mitochondria , and enzyme activity assay revealed the mutant reduced the 11-hydroxylase activity to 10 % -LRB- P < 0.001 -RRB- for the conversion of 11b-deoxycortisol to cortisol .
21926601	5	11b-deoxycortisol	818,835	H12	884,887	11b-deoxycortisol	H12	null	3006	Chemical	Gene	concentrations|amod|START_ENTITY cortisol|conj|concentrations assayed|nsubjpass|cortisol assayed|nmod|H6 H6|conj|END_ENTITY	MEASUREMENTS AND MAIN RESULTS : After completion of a corticotrophin stimulation test , serum cortisol and 11b-deoxycortisol concentrations were subsequently assayed at H6 , H12 , H24 , and H48 .
15456242	0	11beta-alkyl-Delta9-19-nortestosterone	0,38	androgen_receptor	109,126	11beta-alkyl-Delta9-19-nortestosterone	androgen receptor	null	367	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|dep|ligands ligands|conj|agonists agonists|nmod|END_ENTITY	11beta-alkyl-Delta9-19-nortestosterone derivatives : high-affinity ligands and potent partial agonists of the androgen_receptor .
16806946	0	11beta-aryl-substituted_steroids	61,93	progesterone_receptor	4,25	11beta-aryl-substituted steroids	progesterone receptor	null	5241	Chemical	Gene	antagonists|dep|START_ENTITY antagonists|compound|END_ENTITY	New progesterone_receptor antagonists : phosphorus-containing 11beta-aryl-substituted_steroids .
15857972	4	11beta-benzaldoxime-substituted_estratrienes	578,622	progesterone_receptor	694,715	11beta-benzaldoxime-substituted estratrienes	progesterone receptor	null	5241	Chemical	Gene	effects|nummod|START_ENTITY effects|nmod|specificity specificity|compound|END_ENTITY	Asoprisnil belongs to the class of 11beta-benzaldoxime-substituted_estratrienes that exhibit partial progesterone agonist/antagonist effects with high progesterone_receptor specificity in animals and humans .
15714390	3	11beta-benzaldoxime-substituted_steroidal	824,865	PR	893,895	11beta-benzaldoxime-substituted steroidal	PR	null	100724945	Chemical	Gene	compounds|amod|START_ENTITY compounds|acl|exhibiting exhibiting|dobj|effects effects|compound|END_ENTITY	A series of 11beta-benzaldoxime-substituted_steroidal compounds exhibiting mixed PR agonist/antagonist effects were synthesized and characterized .
18427562	5	11beta-dehydrocorticosterone	1025,1053	not_3_h	1099,1106	11beta-dehydrocorticosterone	not 3 h	null	4849	Chemical	Gene	1alpha|conj|START_ENTITY each|amod|1alpha stimulated|nsubj|each stimulated|nmod|h h|dep|END_ENTITY	1alpha , 25-Dihydroxyvitamin_D and 11beta-dehydrocorticosterone each stimulated nVDR expression at 48 h , but not_3_h , by approximately 650 % in fully differentiated adipocytes , whereas the combination augmented this effect -LRB- P < 0.005 -RRB- .
16039525	2	11beta-dichloro	439,454	androgen_receptor	493,510	11beta-dichloro	androgen receptor	null	367	Chemical	Gene	molecule|dep|START_ENTITY molecule|acl:relcl|forms forms|ccomp|adducts adducts|xcomp|END_ENTITY	A DNA alkylator -LRB- N,N-bis-2-chloroethyl _ aniline -RRB- was linked to a steroid ligand -LRB- 17beta-hyroxy-estra-Delta -LRB- 4 -LRB- 5 -RRB- ,9 -LRB- 10 -RRB- -RRB- -3 - one -RRB- to produce a complex molecule -LRB- 11beta-dichloro -RRB- that forms DNA adducts that bind the androgen_receptor -LRB- AR -RRB- .
16648569	1	11beta-dichloro	113,128	androgen_receptor	158,175	11beta-dichloro	androgen receptor	null	11835(Tax:10090)	Chemical	Gene	consists|nsubj|START_ENTITY consists|nmod|ligand ligand|nmod|END_ENTITY	The multifunctional molecule 11beta-dichloro consists of a ligand for the androgen_receptor linked to a bifunctional alkylating group , permitting it to create DNA adducts that bind the androgen_receptor .
16648569	1	11beta-dichloro	113,128	androgen_receptor	269,286	11beta-dichloro	androgen receptor	null	11835(Tax:10090)	Chemical	Gene	consists|nsubj|START_ENTITY consists|nmod|ligand ligand|nmod|androgen_receptor androgen_receptor|acl|linked linked|xcomp|permitting permitting|xcomp|create create|dobj|adducts adducts|acl:relcl|bind bind|dobj|END_ENTITY	The multifunctional molecule 11beta-dichloro consists of a ligand for the androgen_receptor linked to a bifunctional alkylating group , permitting it to create DNA adducts that bind the androgen_receptor .
16648569	8	11beta-dichloro	1374,1389	androgen_receptor	1513,1530	11beta-dichloro	androgen receptor	null	11835(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|stability stability|acl|enter enter|conj|form form|dobj|adducts adducts|acl:relcl|capable capable|advcl|binding binding|dobj|END_ENTITY	Our results indicate that 11beta-dichloro has sufficient stability to enter the circulation , penetrate tissues , and form DNA adducts that are capable of binding the androgen_receptor in target tissues in vivo .
16039525	2	11beta-dichloro	439,454	AR	512,514	11beta-dichloro	AR	null	367	Chemical	Gene	molecule|dep|START_ENTITY molecule|acl:relcl|forms forms|ccomp|adducts adducts|xcomp|androgen_receptor androgen_receptor|appos|END_ENTITY	A DNA alkylator -LRB- N,N-bis-2-chloroethyl _ aniline -RRB- was linked to a steroid ligand -LRB- 17beta-hyroxy-estra-Delta -LRB- 4 -LRB- 5 -RRB- ,9 -LRB- 10 -RRB- -RRB- -3 - one -RRB- to produce a complex molecule -LRB- 11beta-dichloro -RRB- that forms DNA adducts that bind the androgen_receptor -LRB- AR -RRB- .
7877147	1	11_beta-F-DHT	269,282	androgen_receptor	467,484	11 beta-F-DHT	androgen receptor	MESH:C092353	24208(Tax:10116)	Chemical	Gene	beta-fluoro-5_alpha-dihydrotestosterone|dep|START_ENTITY prepared|xcomp|beta-fluoro-5_alpha-dihydrotestosterone prepared|advcl|investigate investigate|dobj|properties properties|nmod|androgens androgens|acl|labeled labeled|nmod|END_ENTITY	We have prepared 11 beta-fluoro-5_alpha-dihydrotestosterone -LRB- 11_beta-F-DHT , 1 -RRB- and 11 beta-fluoro-19-nor-5_alpha-dihydrotestosterone -LRB- 11_beta-F-19-nor-DHT , 2 -RRB- in order to investigate the properties of these new androgens labeled with fluorine-18 as potential androgen_receptor -LRB- AR -RRB- - based imaging agents for prostate_cancer .
7877147	1	11_beta-F-DHT	269,282	AR	486,488	11 beta-F-DHT	AR	MESH:C092353	24208(Tax:10116)	Chemical	Gene	beta-fluoro-5_alpha-dihydrotestosterone|dep|START_ENTITY prepared|xcomp|beta-fluoro-5_alpha-dihydrotestosterone prepared|advcl|investigate investigate|dobj|properties properties|nmod|androgens androgens|acl|labeled labeled|nmod|androgen_receptor androgen_receptor|appos|END_ENTITY	We have prepared 11 beta-fluoro-5_alpha-dihydrotestosterone -LRB- 11_beta-F-DHT , 1 -RRB- and 11 beta-fluoro-19-nor-5_alpha-dihydrotestosterone -LRB- 11_beta-F-19-nor-DHT , 2 -RRB- in order to investigate the properties of these new androgens labeled with fluorine-18 as potential androgen_receptor -LRB- AR -RRB- - based imaging agents for prostate_cancer .
7877147	3	11_beta-F-DHT	702,715	AR	744,746	11 beta-F-DHT	AR	MESH:C092353	24208(Tax:10116)	Chemical	Gene	affinities|acl|START_ENTITY affinities|nmod|END_ENTITY	Relative binding affinities -LRB- RBA -RRB- of 11_beta-F-DHT and 11_beta-F-19-nor-DHT to AR are 53.1 and 75.3 -LRB- R1881 = 100 -RRB- , respectively , the latter being the highest reported among fluorine-substituted androgens .
18367016	3	11beta-hydoxysteroid	643,663	11beta-HSD1	686,697	11beta-hydoxysteroid	11beta-HSD1	null	15483(Tax:10090)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	Recent studies report that these features also occur in subclinical Cushing 's _ syndrome , hypercortisolemic_depression , and the transgenic overexpression of 11beta-hydoxysteroid dehydrogenase type 1 -LRB- 11beta-HSD1 -RRB- in mouse models of excess GC in adipose tissue .
16261451	9	11-beta-hydrosteroid	1259,1279	PTH	1214,1217	11-beta-hydrosteroid	PTH	null	19226(Tax:10090)	Chemical	Gene	mRNA|amod|START_ENTITY level|nmod|mRNA affect|dobj|level affect|nsubj|END_ENTITY	On the other hand , PTH and estrogen did not affect the level of 11-beta-hydrosteroid dehydrogenase type I mRNA increased by Dex .
2511373	5	11-beta-hydroxyandrostenedione	1122,1152	beta-endorphin	1101,1115	11-beta-hydroxyandrostenedione	beta-endorphin	MESH:C003582	5443	Chemical	Gene	ACTH|appos|START_ENTITY ACTH|appos|END_ENTITY	Other hormones are usually elevated , but not always -LRB- ACTH , aldosterone , prolactin , glucagon , immunoreactive insulin , beta-endorphin , rT3 , 11-beta-hydroxyandrostenedione -RRB- , but there are hormones that are unually low -LRB- T4 , FSH , androstenedione , progesterone -- the latter especially in females -RRB- .
24948873	3	11beta-hydroxyandrostenedione	802,831	AR	901,903	11beta-hydroxyandrostenedione	AR	MESH:C003582	367	Chemical	Gene	11-deoxcorticosterone|conj|START_ENTITY steroids|nmod|11-deoxcorticosterone play|nsubj|steroids play|advcl|promoting promoting|dobj|activation activation|compound|END_ENTITY	However , less well-characterized adrenal steroids , including 11-deoxcorticosterone -LRB- DOC -RRB- and 11beta-hydroxyandrostenedione -LRB- 11OH-AED -RRB- may also play a previously unrecognized role in promoting AR activation .
16216911	13	11beta-hydroxyandrostenedione	1710,1739	C-17	1743,1747	11beta-hydroxyandrostenedione	C-17	MESH:C003582	54360	Chemical	Gene	START_ENTITY|nmod|END_ENTITY	Furthermore , we found that both enzymes can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms .
5535601	0	11-beta-hydroxycorticosteroids	78,108	insulin	40,47	11-beta-hydroxycorticosteroids	insulin	null	3630	Chemical	Gene	fatty_acids|amod|START_ENTITY unconjugated|dobj|fatty_acids unconjugated|nsubj|determination determination|nmod|hormone hormone|dep|END_ENTITY	-LSB- Simultaneous determination of glucose , insulin , growth hormone , unconjugated 11-beta-hydroxycorticosteroids , free fatty_acids and amino-nitrogen in the serum of the mother and her newborn child -RSB- .
11696370	1	11beta-hydroxycorticosteroids	293,322	TNF-alpha	189,198	11beta-hydroxycorticosteroids	TNF-alpha	MESH:D015062	397086(Tax:9823)	Chemical	Gene	access|nmod|START_ENTITY regulating|dobj|access enzyme|acl|regulating 11beta-HSD2|appos|enzyme effect|nmod|11beta-HSD2 effect|appos|END_ENTITY	For understanding the mechanism -LRB- s -RRB- relating inflammation to corticosteroid action , the effect of tumour_necrosis factor-alpha -LRB- TNF-alpha -RRB- on 11beta-hydroxysteroid dehydrogenase type 2 -LRB- 11beta-HSD2 -RRB- , the enzyme regulating access of 11beta-hydroxycorticosteroids to receptors , was studied in LLC-PK -LRB- 1 -RRB- cells .
17584152	4	11beta-hydroxyglucocorticoids	754,783	11beta-HSD1	830,841	11beta-hydroxyglucocorticoids	11beta-HSD1	null	3290;26871	Chemical	Gene	conversion|nmod|START_ENTITY catalyzed|nsubjpass|conversion catalyzed|nmod|END_ENTITY	The conversion of inactive 11-ketoglucocorticoids -LRB- cortisone and 11-dehydrocorticosterone -RRB- into active 11beta-hydroxyglucocorticoids -LRB- cortisol and corticosterone -RRB- is catalyzed by 11beta-HSD1 , which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver , adipose tissue and skeletal muscles .
20100662	1	11beta-hydroxyglucocorticoids	305,334	11beta-HSD1	215,226	11beta-hydroxyglucocorticoids	11beta-HSD1	null	3290;26871	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion inhibition|acl:relcl|catalyzes inhibition|nmod|11beta-hydroxysteroid_dehydrogenase_1 11beta-hydroxysteroid_dehydrogenase_1|dep|END_ENTITY	The inhibition of 11beta-hydroxysteroid_dehydrogenase_1 -LRB- 11beta-HSD1 -RRB- , which catalyzes the conversion of inactive 11-ketoglucocorticoids to active 11beta-hydroxyglucocorticoids , emerged as promising strategy to treat symptoms of the metabolic_syndrome , including obesity and type 2 diabetes .
20100662	1	11beta-hydroxyglucocorticoids	305,334	11beta-hydroxysteroid_dehydrogenase_1	176,213	11beta-hydroxyglucocorticoids	11beta-hydroxysteroid dehydrogenase 1	null	3290	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion inhibition|acl:relcl|catalyzes inhibition|nmod|END_ENTITY	The inhibition of 11beta-hydroxysteroid_dehydrogenase_1 -LRB- 11beta-HSD1 -RRB- , which catalyzes the conversion of inactive 11-ketoglucocorticoids to active 11beta-hydroxyglucocorticoids , emerged as promising strategy to treat symptoms of the metabolic_syndrome , including obesity and type 2 diabetes .
24303173	3	11beta-hydroxy-glucocorticosteroid	383,417	mineralocorticoid_receptor	330,356	11beta-hydroxy-glucocorticosteroid	mineralocorticoid receptor	null	25672(Tax:10116)	Chemical	Gene	occurred|nmod|START_ENTITY occurred|nsubj|activation activation|compound|END_ENTITY	Here , we hypothesize that mineralocorticoid_receptor activation occurred by an 11beta-hydroxy-glucocorticosteroid , as a consequence of dysregulated_11beta-hydroxysteroid dehydrogenase enzymes .
10375032	3	11beta-hydroxyprogesterone	464,490	glucocorticoid_receptor	514,537	11beta-hydroxyprogesterone	glucocorticoid receptor	CHEBI:28247	24413(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	11beta-hydroxyprogesterone binds well to both the glucocorticoid_receptor and the carrier protein transcortin .
10375032	3	11beta-hydroxyprogesterone	464,490	transcortin	562,573	11beta-hydroxyprogesterone	transcortin	CHEBI:28247	299270(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|glucocorticoid_receptor glucocorticoid_receptor|conj|END_ENTITY	11beta-hydroxyprogesterone binds well to both the glucocorticoid_receptor and the carrier protein transcortin .
9135568	2	11_beta-hydroxysteroid	391,413	11_beta_HSD1	429,441	11 beta-hydroxysteroid	11 beta HSD1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	It has also been proposed that metabolism of dexamethasone might differentiate between the activities of the two isozymes of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD1 and 11_beta_HSD2 -RRB- .
11150889	13	11_beta-hydroxysteroid	1636,1658	11_beta-HSD1	1674,1686	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	3290	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	This constellation clearly indicates cortisone_reductase_deficiency , a defect of hepatic 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta-HSD1 -RRB- .
11481269	2	11_beta-hydroxysteroid	392,414	11_beta-HSD1	471,483	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	3290	Chemical	Gene	isozymes|amod|START_ENTITY isozymes|dep|oxo-reductase oxo-reductase|dep|END_ENTITY	In peripheral tissues , corticosteroid hormone action is regulated at a prereceptor level through the activity of the 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- isozymes : an oxo-reductase -LRB- 11_beta-HSD1 -RRB- that activates cortisol -LRB- F -RRB- from cortisone -LRB- E -RRB- and a dehydrogenase -LRB- 11 beta-HSD2 -RRB- that inactivates F to E .
16234247	0	11_beta-hydroxysteroid	18,40	11_beta-HSD1	56,68	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Evidence that the 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta-HSD1 -RRB- is regulated by pentose pathway flux .
16234247	2	11_beta-hydroxysteroid	150,172	11_beta-HSD1	195,207	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	type|amod|START_ENTITY type|dep|END_ENTITY	11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11_beta-HSD1 -RRB- catalyzes the interconversion of biologically inactive 11 keto derivatives -LRB- cortisone , 11-dehydrocorticosterone -RRB- to active glucocorticoids -LRB- cortisol , corticosterone -RRB- in fat , liver , and other tissues .
19223399	1	11_beta-hydroxysteroid	168,190	11_beta-HSD1	213,225	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	15483(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|dep|END_ENTITY	In obese humans , metabolism of glucocorticoids by 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11_beta-HSD1 -RRB- and A-ring reduction -LRB- by 5 alpha - and 5 beta-reductases -RRB- is dysregulated in a tissue specific manner .
7495705	1	11_beta-hydroxysteroid	131,153	11_beta-HSD1	171,183	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	3290	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	A novel variant of 11_beta-hydroxysteroid dehydrogenase 1 -LRB- 11_beta-HSD1 -RRB- mRNA was identified from the ovine liver by reverse transcription-polymerase chain reaction -LRB- RT/PCR -RRB- , and was named 11_beta-HSD1C mRNA .
8547171	1	11_beta-hydroxysteroid	86,108	11_beta-HSD1	208,220	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	3290	Chemical	Gene	dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase catalyse|nsubj|isoforms catalyse|parataxis|affinity affinity|nsubj|END_ENTITY	Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of active cortisol to inactive cortisone ; 11_beta-HSD1 is a low affinity , NADP -LRB- H -RRB- - dependent dehydrogenase/oxo-reductase , and 11_beta-HSD2 a high affinity , NAD-dependent dehydrogenase .
17371460	1	11_beta-hydroxysteroid	266,288	11beta-HSD1	306,317	11 beta-hydroxysteroid	11beta-HSD1	CHEBI:35346	3290;26871	Chemical	Gene	dehydrogenase|amod|START_ENTITY effect|nmod|dehydrogenase modulating|nmod|effect plays|advcl|modulating plays|nsubj|1 1|dep|END_ENTITY	The growth_hormone-insulin-like growth factor 1 -LRB- GH-IGF-1 -RRB- axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11_beta-hydroxysteroid dehydrogenase 1 -LRB- 11beta-HSD1 -RRB- which , in vivo , functions as a reductase catalysing the conversion of cortisone to cortisol .
17640483	1	11_beta-hydroxysteroid	138,160	11beta-HSD1	183,194	11 beta-hydroxysteroid	11beta-HSD1	CHEBI:35346	15483(Tax:10090)	Chemical	Gene	END_ENTITY|amod|START_ENTITY	AIM : To investigate the relationship between 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11beta-HSD1 -RRB- , a potential link between obesity and type 2 diabetes , and preadipocyte differentiation .
7593417	1	11_beta-hydroxysteroid	245,267	11_beta_HSD2	283,295	11 beta-hydroxysteroid	11 beta HSD2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Four deleterious mutations are described in the gene for HSD11B2 , which encodes the type 2 isoenzyme of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD2 -RRB- .
9135568	2	11_beta-hydroxysteroid	391,413	11_beta_HSD2	446,458	11 beta-hydroxysteroid	11 beta HSD2	CHEBI:35346	25117(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|11_beta_HSD1 11_beta_HSD1|conj|END_ENTITY	It has also been proposed that metabolism of dexamethasone might differentiate between the activities of the two isozymes of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD1 and 11_beta_HSD2 -RRB- .
14629298	1	11_beta-hydroxysteroid	187,209	11_beta-HSD2	232,244	11 beta-hydroxysteroid	11 beta-HSD2	CHEBI:35346	3291	Chemical	Gene	END_ENTITY|amod|START_ENTITY	We examined the immunohistochemical distribution of 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11_beta-HSD2 -RRB- , the enzyme responsible for the conversion of bioactive glucocorticoids to their receptor-inactive forms , in lung tissue obtained at autopsy from 14 patients who had died due to acute_respiratory_distress_syndrome -LRB- ARDS -RRB- .
7556871	1	11_beta-hydroxysteroid	137,159	11_beta-HSD2	177,189	11 beta-hydroxysteroid	11 beta-HSD2	CHEBI:35346	443530(Tax:9940)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	The cellular localization of 11_beta-hydroxysteroid dehydrogenase 2 -LRB- 11_beta-HSD2 -RRB- gene expression in the ovine adrenal gland was determined by in situ hybridization histochemistry .
8547171	1	11_beta-hydroxysteroid	86,108	11_beta-HSD2	291,303	11 beta-hydroxysteroid	11 beta-HSD2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase catalyse|nsubj|isoforms catalyse|parataxis|affinity affinity|amod|dehydrogenase/oxo-reductase dehydrogenase/oxo-reductase|conj|END_ENTITY	Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of active cortisol to inactive cortisone ; 11_beta-HSD1 is a low affinity , NADP -LRB- H -RRB- - dependent dehydrogenase/oxo-reductase , and 11_beta-HSD2 a high affinity , NAD-dependent dehydrogenase .
8611186	1	11_beta-hydroxysteroid	128,150	11_beta-HSD2	173,185	11 beta-hydroxysteroid	11 beta-HSD2	CHEBI:35346	3291	Chemical	Gene	type|amod|START_ENTITY inactivates|nsubj|type inactivates|advmod|efficiently efficiently|nmod:npmod|2 2|dep|END_ENTITY	11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11_beta-HSD2 -RRB- efficiently inactivates potent glucocorticoid hormones -LRB- cortisol and corticosterone -RRB- , leaving aldosterone unmetabolized .
8977758	1	11_beta-hydroxysteroid	126,148	11_beta-HSD2	267,279	11 beta-hydroxysteroid	11 beta-HSD2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY isoforms|nmod|dehydrogenase OBJECTIVE|dep|isoforms OBJECTIVE|dep|defects defects|nmod|result result|amod|END_ENTITY	OBJECTIVE : Two isoforms of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- catalyse the interconversion of cortisol to hormonally inactive cortisone ; defects in the 11_beta-HSD2 isoform result in hypertension .
18178212	1	11_beta-hydroxysteroid	139,161	11beta-HSD2	179,190	11 beta-hydroxysteroid	11beta-HSD2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY activity|nmod|dehydrogenase activity|acl:relcl|induces induces|nsubj|2 2|dep|END_ENTITY	BACKGROUND : Lower activity of 11_beta-hydroxysteroid dehydrogenase 2 -LRB- 11beta-HSD2 -RRB- classically induces hypertension by leading to an altered tetrahydrocortisol - versus tetrahydrocortisone-metabolites -LRB- THFs/THE -RRB- shuttle .
19075542	1	11_beta-hydroxysteroid	294,316	11beta-HSD2	339,350	11 beta-hydroxysteroid	11beta-HSD2	CHEBI:35346	3291	Chemical	Gene	type|amod|START_ENTITY due|nmod|type state|amod|due state|dep|END_ENTITY	Two elderly patients with mineralocorticoid excess state due to 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11beta-HSD2 -RRB- impairment are described .
9029722	4	11_beta-hydroxysteroid	959,981	15-hydroxyprostaglandin_dehydrogenase	1000,1037	11 beta-hydroxysteroid	15-hydroxyprostaglandin dehydrogenase	CHEBI:35346	873	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|conj|END_ENTITY	The three-dimensional structure of the 3 alpha ,20 beta-HSD carbenoxolone complex unequivocally verifies the postulated active site of the enzyme , shows that inhibition is a result of direct competition with the substrate for binding , and provides a plausible model for the mechanism of inhibition of 11_beta-hydroxysteroid dehydrogenase and 15-hydroxyprostaglandin_dehydrogenase by carbenoxolone .
7828353	16	11_beta-hydroxysteroid	3598,3620	GH	3543,3545	11 beta-hydroxysteroid	GH	CHEBI:35346	2688	Chemical	Gene	dehydrogenase|amod|START_ENTITY activity|nmod|dehydrogenase modulate|dobj|activity modulate|nsubj|END_ENTITY	The changes in F/E suggest that GH may directly or indirectly modulate the activity of 11_beta-hydroxysteroid dehydrogenase .
12605557	9	11_beta-hydroxysteroid	1715,1737	glucagon-like_peptide_1	1792,1815	11 beta-hydroxysteroid	glucagon-like peptide 1	CHEBI:35346	2641	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|conj|modulators modulators|nmod|axis axis|amod|END_ENTITY	These initiatives , together with developments in beta -LRB- 3 -RRB- - adrenoceptor agonists , 11_beta-hydroxysteroid dehydrogenase Type 1 inhibitors and modulators of the glucagon-like_peptide_1 axis , all of which also potentially enhance insulin sensitivity , are critically evaluated .
1734933	0	11_beta-hydroxysteroid	23,45	glucocorticoid_receptor	88,111	11 beta-hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	dehydrogenase|amod|START_ENTITY localization|nmod|dehydrogenase localization|nmod|END_ENTITY	Tissue localization of 11_beta-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid_receptor .
8969930	5	11_beta-hydroxysteroid	1164,1186	glucocorticoid_receptor	1080,1103	11 beta-hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	dehydrogenase|amod|START_ENTITY cortisol|nmod|dehydrogenase inactivation|nmod|cortisol explained|nmod|inactivation explained|nmod|affinity affinity|compound|END_ENTITY	Our data suggest that the increase in dermal glucocorticoid sensitivity is not a secondary phenomenon and may be explained by increased glucocorticoid_receptor affinity together with impaired inactivation of cortisol by 11_beta-hydroxysteroid dehydrogenase .
21802269	6	11_beta-hydroxysteroid	852,874	Glucocorticoid_receptor	822,845	11 beta-hydroxysteroid	Glucocorticoid receptor	CHEBI:35346	14815(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY END_ENTITY|conj|type	Glucocorticoid_receptor -LRB- GR -RRB- , 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11b-HSD1 -RRB- and 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expressions in liver were determined by western blotting .
7649347	0	11_beta-hydroxysteroid	54,76	Glucocorticoid_receptor	0,23	11 beta-hydroxysteroid	Glucocorticoid receptor	CHEBI:35346	24413(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY receptors|appos|expression END_ENTITY|appos|receptors	Glucocorticoid_receptor , mineralocorticoid receptors , 11_beta-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney : in situ studies .
21802269	6	11_beta-hydroxysteroid	852,874	GR	847,849	11 beta-hydroxysteroid	GR	CHEBI:35346	14815(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY Glucocorticoid_receptor|conj|type Glucocorticoid_receptor|appos|END_ENTITY	Glucocorticoid_receptor -LRB- GR -RRB- , 11_beta-hydroxysteroid dehydrogenase type 1 -LRB- 11b-HSD1 -RRB- and 11_beta-hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expressions in liver were determined by western blotting .
8370690	0	11_beta-hydroxysteroid	35,57	HSD11	15,20	11 beta-hydroxysteroid	HSD11	CHEBI:35346	3290	Chemical	Gene	dehydrogenase|amod|START_ENTITY encoding|dobj|dehydrogenase gene|acl|encoding gene|compound|END_ENTITY	Defects in the HSD11 gene encoding 11_beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid_excess_or_11-oxoreductase_deficiency .
7593417	1	11_beta-hydroxysteroid	245,267	HSD11B2	198,205	11 beta-hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY isoenzyme|nmod|dehydrogenase encodes|dobj|isoenzyme gene|acl:relcl|encodes gene|nmod|END_ENTITY	Four deleterious mutations are described in the gene for HSD11B2 , which encodes the type 2 isoenzyme of 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta_HSD2 -RRB- .
12605557	9	11_beta-hydroxysteroid	1715,1737	insulin	1860,1867	11 beta-hydroxysteroid	insulin	CHEBI:35346	3630	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|acl:relcl|enhance enhance|dobj|sensitivity sensitivity|compound|END_ENTITY	These initiatives , together with developments in beta -LRB- 3 -RRB- - adrenoceptor agonists , 11_beta-hydroxysteroid dehydrogenase Type 1 inhibitors and modulators of the glucagon-like_peptide_1 axis , all of which also potentially enhance insulin sensitivity , are critically evaluated .
7792800	1	11_beta-hydroxysteroid	60,82	mineralocorticoid_receptor	292,318	11 beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY pre-receptor|nsubj|dehydrogenase pre-receptor|acl|signaling signaling|nmod|END_ENTITY	11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- , by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone , respectively , is an important pre-receptor signaling pathway for the renal mineralocorticoid_receptor -LRB- MR -RRB- .
8070376	0	11_beta-hydroxysteroid	99,121	mineralocorticoid_receptor	4,30	11 beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY glucocorticoids|nmod|dehydrogenase discriminates|nmod|glucocorticoids discriminates|nsubj|END_ENTITY	The mineralocorticoid_receptor discriminates aldosterone from glucocorticoids independently of the 11_beta-hydroxysteroid dehydrogenase .
8070376	1	11_beta-hydroxysteroid	325,347	mineralocorticoid_receptor	222,248	11 beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY receptor|conj|dehydrogenase contribution|nmod|receptor studied|dobj|contribution studied|advcl|investigate investigate|dobj|mechanisms mechanisms|acl|involved involved|nmod|selectivity selectivity|nmod|END_ENTITY	To investigate the mechanisms involved in the in vivo aldosterone selectivity of the mineralocorticoid_receptor -LRB- MR -RRB- , we studied the respective contribution of the receptor and the enzyme 11_beta-hydroxysteroid dehydrogenase -LRB- 11HSD -RRB- , which converts glucocorticoids into inactive metabolites .
8191539	3	11_beta-hydroxysteroid	530,552	mineralocorticoid_receptor	612,638	11 beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY action|nmod|dehydrogenase position|nmod|action glucocorticoids|nmod|position Inactivation|nmod|glucocorticoids permits|nsubj|Inactivation permits|dobj|occupation occupation|nmod|END_ENTITY	Inactivation of glucocorticoids at the 11-hydroxyl position by the action of 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-OHSD -RRB- permits the occupation of the mineralocorticoid_receptor by aldosterone in the presence of much higher levels of circulating cortisol .
8191539	6	11_beta-hydroxysteroid	1069,1091	mineralocorticoid_receptor	1246,1272	11 beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY attributes|nmod|dehydrogenase isozymes|nsubj|attributes isozymes|dobj|reasons reasons|acl:relcl|appears appears|xcomp|candidate candidate|acl|endow endow|nmod|END_ENTITY	This review examines the attributes of these 11_beta-hydroxysteroid dehydrogenase isozymes and suggests reasons why a high affinity , NAD-dependent enzyme appears to be the most likely candidate to endow specificity on the mineralocorticoid_receptor .
7600648	4	11_beta-hydroxysteroid	564,586	MR	418,420	11 beta-hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY presence|nmod|dehydrogenase requires|dobj|presence requires|advcl|displays displays|nsubj|END_ENTITY	Because MR displays similar affinities for aldosterone and glucocorticoids , the in vivo aldosterone selectivity of MR requires the presence of an enzyme , 11_beta-hydroxysteroid dehydrogenase -LRB- 11-HSD -RRB- , which metabolizes glucocorticoids into inactive derivatives .
7600648	4	11_beta-hydroxysteroid	564,586	MR	525,527	11 beta-hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY presence|nmod|dehydrogenase requires|dobj|presence requires|nsubj|selectivity selectivity|nmod|END_ENTITY	Because MR displays similar affinities for aldosterone and glucocorticoids , the in vivo aldosterone selectivity of MR requires the presence of an enzyme , 11_beta-hydroxysteroid dehydrogenase -LRB- 11-HSD -RRB- , which metabolizes glucocorticoids into inactive derivatives .
7792800	1	11_beta-hydroxysteroid	60,82	MR	320,322	11 beta-hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY pre-receptor|nsubj|dehydrogenase pre-receptor|acl|signaling signaling|nmod|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY	11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- , by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone , respectively , is an important pre-receptor signaling pathway for the renal mineralocorticoid_receptor -LRB- MR -RRB- .
8070376	1	11_beta-hydroxysteroid	325,347	MR	250,252	11 beta-hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	dehydrogenase|amod|START_ENTITY receptor|conj|dehydrogenase contribution|nmod|receptor studied|dobj|contribution studied|advcl|investigate investigate|dobj|mechanisms mechanisms|acl|involved involved|nmod|selectivity selectivity|nmod|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY	To investigate the mechanisms involved in the in vivo aldosterone selectivity of the mineralocorticoid_receptor -LRB- MR -RRB- , we studied the respective contribution of the receptor and the enzyme 11_beta-hydroxysteroid dehydrogenase -LRB- 11HSD -RRB- , which converts glucocorticoids into inactive metabolites .
1338959	1	11_beta-hydroxysteroid	137,159	POMC	101,105	11 beta-hydroxysteroid	POMC	CHEBI:35346	443212(Tax:9940)	Chemical	Gene	dehydrogenase|amod|START_ENTITY Expression|conj|dehydrogenase Expression|appos|END_ENTITY	Expression of genes encoding pro-opiomelanocortin -LRB- POMC -RRB- , glucocorticoid_receptors and 11_beta-hydroxysteroid dehydrogenase -LRB- 11 beta-HSD -RRB- was studied in sheep fetuses during development .
1639208	0	11_beta-hydroxysteroid	0,22	SCAD	80,84	11 beta-hydroxysteroid	SCAD	CHEBI:35346	35	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	11_beta-hydroxysteroid dehydrogenase and the short-chain_alcohol_dehydrogenase -LRB- SCAD -RRB- superfamily .
1639208	0	11_beta-hydroxysteroid	0,22	short-chain_alcohol_dehydrogenase	45,78	11 beta-hydroxysteroid	short-chain alcohol dehydrogenase	CHEBI:35346	35	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|conj|END_ENTITY	11_beta-hydroxysteroid dehydrogenase and the short-chain_alcohol_dehydrogenase -LRB- SCAD -RRB- superfamily .
2239425	3	11_beta-hydroxysteroid	480,502	transcortin	452,463	11 beta-hydroxysteroid	transcortin	CHEBI:35346	866	Chemical	Gene	dehydrogenase|amod|START_ENTITY END_ENTITY|conj|dehydrogenase	Ligand specificity of mineralocorticoid_receptors for either corticosterone or aldosterone seems to be determined by co-localized transcortin and the enzyme , 11_beta-hydroxysteroid dehydrogenase .
20515440	2	11-beta_hydroxysteroid	314,336	11beta-HSD1	376,387	11-beta hydroxysteroid	11beta-HSD1	CHEBI:35346	3290;26871	Chemical	Gene	dehydrogenase|amod|START_ENTITY 11beta-HSD|appos|dehydrogenase 11beta-HSD|amod|11beta-HSD2 11beta-HSD2|conj|END_ENTITY	Cortisol activation of vascular mineralocorticoid and glucocorticoid receptors is regulated by two types of 11beta-HSD -LRB- 11-beta_hydroxysteroid dehydrogenase -RRB- , namely 11beta-HSD2 and 11beta-HSD1 -LRB- type 2 and type 1 11beta-HSD respectively -RRB- .
26365331	9	11-beta_hydroxysteroid	1171,1193	11bHSD-1	1211,1219	11-beta hydroxysteroid	11bHSD-1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	dehydrogenase-1|amod|START_ENTITY dehydrogenase-1|dep|END_ENTITY	Mediators of hepatic glucocorticoid metabolism , specifically 11-beta_hydroxysteroid dehydrogenase-1 -LRB- 11bHSD-1 -RRB- , 5-a reductase , and glucocorticoid and mineralocorticoid receptor mRNAs were also measured .
19646461	0	11-beta_hydroxysteroid	69,91	glucocorticoid_receptor	41,64	11-beta hydroxysteroid	glucocorticoid receptor	CHEBI:35346	24413(Tax:10116)	Chemical	Gene	END_ENTITY|conj|START_ENTITY	Effects of a high-salt diet on adipocyte glucocorticoid_receptor and 11-beta_hydroxysteroid dehydrogenase 1 in salt-sensitive hypertensive rats .
25459891	2	11-beta_hydroxysteroid	551,573	glucocorticoid_receptor	470,493	11-beta hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	dehydrogenase|amod|START_ENTITY genes|conj|dehydrogenase genes|conj|END_ENTITY	DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior .
22238371	2	11-beta_hydroxysteroid	285,307	HSD11B1	323,330	11-beta hydroxysteroid	HSD11B1	CHEBI:35346	3290	Chemical	Gene	dehydrogenase|amod|START_ENTITY Variation|nmod|dehydrogenase Variation|appos|END_ENTITY	Variation in 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B1 -RRB- is associated with cortisone_reductase_deficiency , a condition with a phenotype similar to PCOS .
22432047	2	11-beta_hydroxysteroid	364,386	HSD11B2	338,345	11-beta hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	enzyme|amod|START_ENTITY regulated|nsubjpass|enzyme encoding|ccomp|regulated encoding|nsubj|gene gene|compound|END_ENTITY	In the placenta , the HSD11B2 gene encoding the 11-beta_hydroxysteroid dehydrogenase enzyme , which is responsible for the inactivation of maternal cortisol , is regulated by DNA methylation , and has been shown to be susceptible to stressors from the maternal environment .
24040322	3	11-beta_hydroxysteroid	474,496	HSD11B2	449,456	11-beta hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	enzyme|amod|START_ENTITY encodes|dobj|enzyme encodes|nsubj|gene gene|compound|END_ENTITY	In the placenta , the HSD11B2 gene encodes the 11-beta_hydroxysteroid dehydrogenase enzyme , which is responsible for the inactivation of maternal cortisol thereby protecting the developing fetus from this exposure .
25459891	2	11-beta_hydroxysteroid	551,573	HSD11B2	589,596	11-beta hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior .
28502862	3	11-beta_hydroxysteroid	398,420	HSD11B2	453,460	11-beta hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	type|amod|START_ENTITY type|appos|11b-HSD2 11b-HSD2|dep|gene gene|compound|END_ENTITY	The placental enzyme 11-beta_hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 , HSD11B2 gene -RRB- acts as a barrier protecting the fetus from maternal corticosteroid deleterious effects .
12711009	2	11-beta_hydroxysteroid	529,551	MR	362,364	11-beta hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	11-dehydroderivatives|advcl|START_ENTITY dehydrogenase|amod|11-dehydroderivatives require|nmod|dehydrogenase require|advcl|prevent prevent|dobj|occupancy occupancy|nmod|END_ENTITY	To prevent permanent and maximal occupancy of MR by glucocorticoid hormones in aldosterone-target cells , specific effects of aldosterone require metabolism of glucocorticoid hormones into 11-dehydroderivatives by 11-beta_hydroxysteroid dehydrogenase -LRB- 11-HSD2 -RRB- .
23152847	4	11-beta_hydroxysteroid	626,648	MR	580,582	11-beta hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|conj|expression	Three hours after onset of EIU , the MR and the glucocorticoid metabolizing enzyme 11-beta_hydroxysteroid dehydrogenase type 2 -LRB- 11b-HSD2 -RRB- expression were down-regulated in iris/ciliary body and the corticosterone concentration was increased in aqueous_humor , altering the normal MR/glucocorticoid receptor -LRB- GR -RRB- balance .
25459891	2	11-beta_hydroxysteroid	551,573	NR3C1	495,500	11-beta hydroxysteroid	NR3C1	CHEBI:35346	2908	Chemical	Gene	dehydrogenase|amod|START_ENTITY genes|conj|dehydrogenase genes|conj|glucocorticoid_receptor glucocorticoid_receptor|appos|END_ENTITY	DNA methylation of two related cortisol response genes , the glucocorticoid_receptor -LRB- NR3C1 -RRB- , a nuclear receptor to which cortisol binds , and 11-beta_hydroxysteroid dehydrogenase -LRB- HSD11B2 -RRB- , the enzyme responsible for conversion of cortisol into inactive cortisone , independently associate with infant_neurobehavior .
21879473	1	11-beta-hydroxysteroid	129,151	11-beta-HSD1	174,186	11-beta-hydroxysteroid	11-beta-HSD1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	I|amod|START_ENTITY I|dep|END_ENTITY	BACKGROUND : 11-beta-hydroxysteroid dehydrogenase type I -LRB- 11-beta-HSD1 -RRB- in the white_adipose_tissue -LRB- WAT -RRB- of rats catalyses the conversion of 11-dehydrocorticosterone to corticosterone , a more active glucocorticosteroid .
16941796	2	11-beta-hydroxysteroid	222,244	11-beta-HSD-1	262,275	11-beta-hydroxysteroid	11-beta-HSD-1	MESH:D006914	3290	Chemical	Gene	perilipins|conj|START_ENTITY enzyme|amod|perilipins enzyme|dep|END_ENTITY	An hypothesis that aberrant expression of perilipins and 11-beta-hydroxysteroid dehydrogenase-1 -LRB- 11-beta-HSD-1 -RRB- enzyme plays a significant role in the development of metabolic_syndrome X in Indians is proposed .
17616511	1	11-beta-hydroxysteroid	237,259	At5g50600	179,188	11-beta-hydroxysteroid	At5g50600	CHEBI:35346	835129(Tax:3702)	Chemical	Gene	dehydrogenase|amod|START_ENTITY protein|nmod|dehydrogenase encodes|dobj|protein AtHSD1|acl:relcl|encodes AtHSD1|appos|END_ENTITY	We have functionally characterized an Arabidopsis -LRB- Arabidopsis_thaliana -RRB- gene AtHSD1 -LRB- At5g50600 -RRB- that encodes a protein with homology to animal 11-beta-hydroxysteroid dehydrogenase -LRB- HSD -RRB- .
17616511	1	11-beta-hydroxysteroid	237,259	AtHSD1	171,177	11-beta-hydroxysteroid	AtHSD1	CHEBI:35346	835141(Tax:3702)	Chemical	Gene	dehydrogenase|amod|START_ENTITY protein|nmod|dehydrogenase encodes|dobj|protein END_ENTITY|acl:relcl|encodes	We have functionally characterized an Arabidopsis -LRB- Arabidopsis_thaliana -RRB- gene AtHSD1 -LRB- At5g50600 -RRB- that encodes a protein with homology to animal 11-beta-hydroxysteroid dehydrogenase -LRB- HSD -RRB- .
15246063	7	11-beta-hydroxysteroid	1083,1105	ATS1	1026,1030	11-beta-hydroxysteroid	ATS1	CHEBI:35346	840112(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|conj|protein protein|nmod|protein oleosins|appos|protein oleosins|appos|END_ENTITY	This led to the identification of a limited number of proteins : four different oleosins , ATS1 , a protein homologous to calcium binding protein , a 11-beta-hydroxysteroid dehydrogenase-like protein , a probable aquaporin and a glycosylphosphatidylinositol-anchored protein with no known function .
21803757	6	11-beta-hydroxysteroid	872,894	CYP19	864,869	11-beta-hydroxysteroid	CYP19	CHEBI:35346	1588	Chemical	Gene	I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|appos|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
16675933	6	11-beta-hydroxysteroid	1017,1039	CYP3A	1065,1070	11-beta-hydroxysteroid	CYP3A	CHEBI:35346	1576	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|amod|type-1 type-1|conj|END_ENTITY	To add to the complexity , endocrine and paracrine cortisol levels and actions depend much on the activity of metabolizing enzymes , such as 11-beta-hydroxysteroid dehydrogenase type-1 and CYP3A .
21803757	6	11-beta-hydroxysteroid	872,894	ESR1	1036,1040	11-beta-hydroxysteroid	ESR1	CHEBI:35346	2099	Chemical	Gene	I|amod|START_ENTITY receptor|compound|I receptor|appos|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
21803757	6	11-beta-hydroxysteroid	872,894	ESR2	1045,1049	11-beta-hydroxysteroid	ESR2	CHEBI:35346	2100	Chemical	Gene	I|amod|START_ENTITY receptor|compound|I receptor|appos|ESR1 ESR1|conj|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
21803757	6	11-beta-hydroxysteroid	872,894	GCR	1080,1083	11-beta-hydroxysteroid	GCR	CHEBI:35346	2908	Chemical	Gene	I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|conj|-RSB- -RSB-|appos|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
12570714	2	11-beta-hydroxysteroid	295,317	glucagon_receptor	252,269	11-beta-hydroxysteroid	glucagon receptor	CHEBI:35346	2642	Chemical	Gene	dehydrogenase-1|amod|START_ENTITY END_ENTITY|conj|dehydrogenase-1	Antagonists of the glucagon_receptor , glycogen phosphorylase , 11-beta-hydroxysteroid dehydrogenase-1 and fructose 1,6-bisphosphatase are , or have been , under evaluation in human clinical trials .
19048413	0	11-beta-hydroxysteroid	32,54	glucocorticoid_receptor	80,103	11-beta-hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	type|amod|START_ENTITY type|conj|END_ENTITY	Immunohistochemical analysis of 11-beta-hydroxysteroid dehydrogenase type 2 and glucocorticoid_receptor in subclinical Cushing 's _ disease due to pituitary_macroadenoma .
21803757	6	11-beta-hydroxysteroid	872,894	glucocorticoid_receptor	1055,1078	11-beta-hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	I|amod|START_ENTITY receptor|compound|I aromatase|conj|receptor aromatase|conj|-RSB- -RSB-|amod|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
24443823	7	11-beta-hydroxysteroid	1100,1122	glucocorticoid_receptor	1020,1043	11-beta-hydroxysteroid	glucocorticoid receptor	CHEBI:35346	2908	Chemical	Gene	type|amod|START_ENTITY END_ENTITY|conj|type	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
24443823	7	11-beta-hydroxysteroid	1100,1122	GR	1045,1047	11-beta-hydroxysteroid	GR	CHEBI:35346	2908	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|appos|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
21803757	6	11-beta-hydroxysteroid	872,894	H6PD	963,967	11-beta-hydroxysteroid	H6PD	CHEBI:35346	9563	Chemical	Gene	I|amod|START_ENTITY I|conj|-RSB- -RSB-|appos|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
21803757	6	11-beta-hydroxysteroid	872,894	hexose-6-phosphate_dehydogenase	930,961	11-beta-hydroxysteroid	hexose-6-phosphate dehydogenase	CHEBI:35346	9563	Chemical	Gene	I|amod|START_ENTITY I|conj|-RSB- -RSB-|amod|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
21803757	6	11-beta-hydroxysteroid	872,894	HSD11B1	917,924	11-beta-hydroxysteroid	HSD11B1	CHEBI:35346	3290	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Functional polymorphic variants were selected in genes that affect the production of estradiol and cortisol -LSB- aromatase -LRB- CYP19 -RRB- , 11-beta-hydroxysteroid dehydrogenase type I -LRB- HSD11B1 -RRB- and hexose-6-phosphate_dehydogenase -LRB- H6PD -RRB- -RSB- and in genes for signal transduction proteins -LSB- estrogen receptor -LRB- ESR1 and ESR2 -RRB- and glucocorticoid_receptor -LRB- GCR -RRB- -RSB- .
24443823	7	11-beta-hydroxysteroid	1100,1122	HSD11B2	1161,1168	11-beta-hydroxysteroid	HSD11B2	CHEBI:35346	3291	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type _|nsubj|glucocorticoid_receptor _|ccomp|quantified quantified|nsubjpass|levels levels|appos|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
17565863	0	11-beta-hydroxysteroid	46,68	mineralocorticoid_receptor	15,41	11-beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	END_ENTITY|conj|START_ENTITY	-LSB- Expression of mineralocorticoid_receptor and 11-beta-hydroxysteroid dehydrogenase type 2 in human atria during chronic atrial_fibrillation : study of 25 cases -RSB- .
24443823	7	11-beta-hydroxysteroid	1100,1122	mineralocorticoid_receptor	1057,1083	11-beta-hydroxysteroid	mineralocorticoid receptor	CHEBI:35346	4306	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
24443823	7	11-beta-hydroxysteroid	1100,1122	MR	1085,1087	11-beta-hydroxysteroid	MR	CHEBI:35346	4306	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|mineralocorticoid_receptor mineralocorticoid_receptor|appos|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
24443823	7	11-beta-hydroxysteroid	1100,1122	NR3C1	1049,1054	11-beta-hydroxysteroid	NR3C1	CHEBI:35346	2908	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|appos|GR GR|dep|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
24443823	7	11-beta-hydroxysteroid	1100,1122	NR3C2	1089,1094	11-beta-hydroxysteroid	NR3C2	CHEBI:35346	4306	Chemical	Gene	type|amod|START_ENTITY glucocorticoid_receptor|conj|type glucocorticoid_receptor|conj|mineralocorticoid_receptor mineralocorticoid_receptor|appos|MR MR|dep|END_ENTITY	Relative glucocorticoid_receptor -LRB- GR ; NR3C1 -RRB- , mineralocorticoid_receptor -LRB- MR ; NR3C2 -RRB- and 11-beta-hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- mRNA levels were quantified by real-time PCR .
18287225	5	11beta_hydroxysteroid	724,745	beta3_adrenergic_receptor	824,849	11beta hydroxysteroid	beta3 adrenergic receptor	MESH:D006914	155	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	beta3AR	851,858	11beta hydroxysteroid	beta3AR	MESH:D006914	155	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|beta3_adrenergic_receptor beta3_adrenergic_receptor|appos|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	deiodinase_type_1	861,878	11beta hydroxysteroid	deiodinase type 1	MESH:D006914	1733	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	DIO1	880,884	11beta hydroxysteroid	DIO1	MESH:D006914	1733	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|deiodinase_type_1 deiodinase_type_1|appos|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	DIO2	890,894	11beta hydroxysteroid	DIO2	MESH:D006914	1734	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	glucocorticoid_receptor	794,817	11beta hydroxysteroid	glucocorticoid receptor	MESH:D006914	2908	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	GR	819,821	11beta hydroxysteroid	GR	MESH:D006914	2908	Chemical	Gene	and_2|amod|START_ENTITY and_2|conj|glucocorticoid_receptor glucocorticoid_receptor|appos|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	HSD11B2	784,791	11beta hydroxysteroid	HSD11B2	MESH:D006914	3291	Chemical	Gene	and_2|amod|START_ENTITY and_2|appos|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	PGC1alpha	991,1000	11beta hydroxysteroid	PGC1alpha	MESH:D006914	10891	Chemical	Gene	and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|conj|PPARgamma PPARgamma|dep|coactivator coactivator|appos|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	PPARgamma	966,975	11beta hydroxysteroid	PPARgamma	MESH:D006914	5468	Chemical	Gene	and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|conj|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	UCP1	712,716	11beta hydroxysteroid	UCP1	MESH:D006914	7350	Chemical	Gene	and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|nmod|UCP2 UCP2|compound|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_proliferator_activated_receptor _ -LRB- PPAR -RRB- _ alpha and gamma and PPARgamma coactivator 1 -LRB- PGC1alpha -RRB- .
18287225	5	11beta_hydroxysteroid	724,745	UCP2	718,722	11beta hydroxysteroid	UCP2	MESH:D006914	7351	Chemical	Gene	and_2|amod|START_ENTITY mRNA|conj|and_2 mRNA|nmod|END_ENTITY	Quantitative real-time PCR was used to analyze mRNA for UCP1 , UCP2 , 11beta_hydroxysteroid dehydrogenase type 1 -LRB- HSD11B1 -RRB- _ and_2 -LRB- HSD11B2 -RRB- , glucocorticoid_receptor -LRB- GR -RRB- , beta3_adrenergic_receptor -LRB- beta3AR -RRB- , deiodinase_type_1 -LRB- DIO1 -RRB- and DIO2 , peroxisome_