10.1186/s12884-017-1537-8
https://zenodo.org/records/1035475
oai:zenodo.org:1035475
Padmapriya, Natarajan
Natarajan
Padmapriya
0000-0002-6077-6316
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Bernard, Jonathan Y.
Jonathan Y.
Bernard
Singapore Institute for Clinical Sciences, Agency for Science and Technology Research (A*STAR), Singapore, Singapore
Liang, Shen
Shen
Liang
Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Loy, See Ling
See Ling
Loy
KK Women's and Children's Hospital, Singapore, Singapore
Cai, Shirong
Shirong
Cai
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Zhe, Iris Shen
Iris Shen
Zhe
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Kwek, Kenneth
Kenneth
Kwek
KK Women's and Children's Hospital, Singapore, Singapore
Godfrey, Keith M.
Keith M.
Godfrey
Medical Research Council Lifecourse Epidemiology Unit, Southampton, UK
Gluckman, Peter D.
Peter D.
Gluckman
Singapore Institute for Clinical Sciences, Agency for Science and Technology Research (A*STAR), Singapore, Singapore
Saw, Seang Mei
Seang Mei
Saw
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
Chong, Yap-Seng
Yap-Seng
Chong
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Chan, Jerry Kok Yen
Jerry Kok Yen
Chan
KK Women's and Children's Hospital, Singapore, Singapore
Müller-Riemenschneider, Falk
Falk
Müller-Riemenschneider
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
on behalf of the GUSTO Study Group
on behalf of the GUSTO Study Group
Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore
Zenodo
2017
Physical activity
Sedentary behavior
Gestational diabetes mellitus
Maternal glucose levels
Pregnancy
2017-10-18
https://zenodo.org/communities/fp7-bmc
https://zenodo.org/communities/eu
Creative Commons Attribution 4.0 International
Background: Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women.
Methods: As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26–28 weeks' gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression.
Results: Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend < 0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (−0.59, −0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32–0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m2, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29–0.93), p = 0.028, and OR: 0.34, (0.15–0.77), p = 0.010, respectively].
Conclusion: Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia.
European Commission
10.13039/501100000780
289346
Long-term effects of early nutrition on later health