Journal article Open Access

Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

C. Menni; J. Zierer; T. Pallister; M.A. Jackson; T. Long; R.P. Mohney; C.J. Steves; T.D. Spector; A.M. Valdes


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  <identifier identifierType="URL">https://zenodo.org/record/1007777</identifier>
  <creators>
    <creator>
      <creatorName>C. Menni</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.</affiliation>
    </creator>
    <creator>
      <creatorName>J. Zierer</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.     Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany.</affiliation>
    </creator>
    <creator>
      <creatorName>T. Pallister</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.</affiliation>
    </creator>
    <creator>
      <creatorName>M.A. Jackson</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.</affiliation>
    </creator>
    <creator>
      <creatorName>T. Long</creatorName>
      <affiliation>Sanford Burnham Prebys, La Jolla, USA.</affiliation>
    </creator>
    <creator>
      <creatorName>R.P. Mohney</creatorName>
      <affiliation>Metabolon Inc., Research Triangle Park, NC, 27709, USA.</affiliation>
    </creator>
    <creator>
      <creatorName>C.J. Steves</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.</affiliation>
    </creator>
    <creator>
      <creatorName>T.D. Spector</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK.</affiliation>
    </creator>
    <creator>
      <creatorName>A.M. Valdes</creatorName>
      <affiliation>Department of Twin Research, King's College London, London, UK. Ana.Valdes@nottingham.ac.uk. School of Medicine, Nottingham City Hospital, Hucknall Road, Nottingham, UK. Ana.Valdes@nottingham.ac.uk.     NIHR Nottingham Biomedical Research Centre, Nottingham, UK. Ana.Valdes@nottingham.ac.uk.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-09-11</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/1007777</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/s41598-017-10382-2</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/heals</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10&lt;sup&gt;-7&lt;/sup&gt;). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/603946/">603946</awardNumber>
      <awardTitle>Health and Environment-wide Associations based on Large population Surveys</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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