Journal article Open Access

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF CHONEMORPHA FRAGRANS AND ERYTHROXYLUM MONOGYNUM COMBINED ETHANOLIC LEAF EXTRACT IN ALLOXAN INDUCED DIABETIC WISTAR RATS

Kausar Fatima*, Konde Abbulu

The objective of the present study was to evaluate the antidiabetic and antihyperlipidemic activity of herbal formulation containing Chonemorpha fragrans and Erythroxylum monogynum in alloxan induced diabetic rats. Diabetes mellitus is a group of syndrome characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Hyperlipidemia constitutes a major etiopathological factor for atherosclerosis. The preliminary phytochemical screening shows the presence of alkaloids, glycosides, carbohydrates, flavonoids, tannins, saponins, sterols, phenols and proteins. The antidiabetic and antihyperlipidemic effect of combined herbal formulation was studied in alloxan (150mg/kg b.w., i.p.) induced diabetes in wistar rats for doses 200 mg/kg b.w. and 400 mg/kg b.w. (p.o.) daily for 21 days, and the effect was compared with oral dose of 5mg/kg, b.w. glibenclamide. The effect of ethanolic leaf extracts of Chonemorpha fragrans and Erythroxylum monogynum on blood glucose, serum lipid profile total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) were measured in the diabetic rats. Diabetes caused by alloxan treatment increases the level of glucose and biochemical parameters in blood sample but treatment with combined herbal formulation, protects from diabetes and significantly decreases the elevated blood glucose, LDL, VLDL levels, total cholesterol levels and total triglycerides levels & increases the HDL levels. In conclusion the present study indicates that the combined ethanolic leaf extracts of plants Chonemorpha fragrans and Erythroxylum monogynum possesses significant antidiabetic, antihyperlipidemic activity in alloxan induced diabetic rats.

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