The Atlas of Variant Effects (AVE) Alliance is an international collaborative founded in 2020 whose efforts are focused on developing, disseminating and democratizing the foundational experimental and analytical technologies for mapping variant effects. Our collective vision is to create a comprehensive atlas (collection of variant effect maps) for important regions of human and human pathogen genomes that could ultimately assist in the diagnosis, prognosis and treatment of disease. (https://www.varianteffect.org)