A large proportion of survivors among extremely preterm new-borns (<28 weeks) face lifelong disabilities associated with cardiovascular, neurological, breathing and metabolic problems. Current approach involves initiation of organ functions but the lungs and gut in preterm organs are not suited for such interventions. The EU-funded consortium will design and develop a totally new system of care for these new-borns by recreating ex vivo innate foetal cardiorespiratory physiological conditions. The system will include an artificial placenta with oxygen and nutrients exchange, continuous non-invasive monitoring of foetal parameters, foetal manikin for simulation of the new-born and corresponding computational modelling. An interdisciplinary team of academia and industry partners have joined forces to demonstrate the functionality of the system in a proof-of-principle.