This community is meant to collect all research materials (peer-reviewed publications, public deliverables, reports, presentations, technical documents) of the 6 Horizon 2020 Research and Innovation Actions (RIAs) funded within the call topic SC1-BHC-05-2018 - International flagship collaboration with Canada for human data storage, integration and sharing to enable personalised medicine approaches, described below.

1. CINECA (Common Infrastructure for National Cohorts in Europe, Canada, and Africa): CINECA’s vision is a federated, cloud-enabled infrastructure making population-scale genomic and biomolecular data accessible across international borders, accelerating research and improving the health of individuals across continents. CINECA will leverage international investment in human cohort studies from Europe, Canada and Africa to deliver a paradigm shift of federated research and clinical applications. CINECA will create one of the largest cross-continental implementations of human genetic and phenotypic data federation and interoperability with a focus on common (complex) disease.

2. euCanSHare (An EU-Canada joint infrastructure for next-generation, multi-Study Heart research): this project aims at developing a translational research platform for cardiovascular data sharing between the European Union (EU) and Canada. Once established, researchers will benefit from a consolidated one-stop, integrated data shop to perform efficient and effective research based on data-driven approaches linking molecular, imaging, functional and clinical data. The end goal is tailor-made patient treatment and better cardiovascular disease outcomes. The project integrates more than 35 Canadian and European cohorts that make up over 1 million records.

3. EUCANCan (European Canadian Cancer Network): the project aims to build a federated infrastructure across EU and Canada to enable personalized medicine in oncology by the generation and sharing of harmonized genomic and phenotypic data. EUCANCan builds on work performed by its consortium members and related projects to align and interconnect existing infrastructures for the analysis and management of genomic oncology data. The EUCANCan network is composed of reference nodes in Amsterdam, Barcelona, Berlin, Heidelberg, Paris and Toronto with strong research and clinical programs in the field of genomic oncology.

4. EUCAN-Connect (A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health): the project will enable large-scale integrated cohort data analysis for personalized and preventive healthcare across EU and Canada. This will be based on an open, scalable data platform for cohorts, researchers and networks, incorporating FAIR principles (Findable, Accessible, Interoperable, Reusable) for optimal reuse of existing data, and building on maturing federated technologies, with sensitive data kept locally and only results being shared and integrated, in line with key ELSI and governance guidelines.

5. iReceptor Plus (Architecture and tools for the query of antibody and t-cell receptor sequencing data repositories for enabling improved personalized medicine and immunotherapy): the project aims to facilitate the sharing of AIRR-seq data among multiple institutions for a better understanding of the causes of infectious and autoimmune diseases and cancer. Its consortium of researchers from EU and Canada will address several key challenges to the optimal sharing of AIRR-seq data among public and industrial partners, such as patient privacy, intellectual property, data integration and harmonisation, to support early detection, identification of novel therapies and possibly reduce the social and economic burden of these diseases worldwide.

6. ReCoDID (Integrated human data repositories for infectious disease-related international cohorts to foster personalized medicine approaches to infectious disease research): the project builds on existing infrastructures and partnerships to develop a sustainable model for the storage, curation and analyses of the complex data sets collected by infectious disease (ID)-related cohorts. Drawing from best practice and governance elaborated for similar initiatives, the repository will employ a federated model where a tiered permission system and cohort-specific hubs facilitate cohorts’ analysis of their own data, cross-cohort analyses and connections with the open science community within a clearly elaborated legal, ethical, and equitable framework.

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This community is meant to collect all research materials (e.g., peer-reviewed publications, public deliverables, reports, presentations, technical documents) of EUCAN, a group of 6 Horizon 2020 Research and Innovation Actions (RIAs) funded within the call topic SC1-BHC-05-2018 - International flagship collaboration with Canada for human data storage, integration and sharing to enable personalised medicine approaches, namely CINECA, EUCANCan, EUCAN-Connect, euCanSHare, iReceptor Plus, and ReCoDID.

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Curation policy:

The Communication and Dissemination (C&D) Manager of each project will be responsible for adding to the EUCAN community any project-related material ascribable to the above-mentioned categories, published within the project timeframe or after its conclusion and pertinent to its results. A C&D Coordinator appointed for the group will review the content periodically (at least every 6 months), to ensure the above conditions for the uploaded materials are met. 

July 15, 2020
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