ENTRY       zma04145                    Pathway
NAME        Phagosome - Zea mays (maize)
DESCRIPTION Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP zma04145  Phagosome
DBLINKS     GO: 0045335
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100193453  uncharacterized protein LOC100193453 [KO:K08492]
            100280225  Syntaxin 81 [KO:K08492]
            100272807  uncharacterized protein LOC100272807 [KO:K08517]
            103644161  25.3 kDa vesicle transport protein [KO:K08517]
            100191530  uncharacterized protein LOC100191530 [KO:K07889]
            100193933  ras-related protein RABF2a [KO:K07889]
            103631302  ras-related protein Rab5A [KO:K07889]
            103640217  ras-related protein Rab5A [KO:K07889]
            103643941  late embryogenesis abundant protein 19 [KO:K07889]
            103653397  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
            542327  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
            103626681  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
            100282598  vacuolar ATP synthase subunit B [KO:K02147]
            100286306  vacuolar ATP synthase subunit B [KO:K02147]
            100274416  uncharacterized protein LOC100274416 [KO:K02148]
            100281241  uncharacterized protein LOC100281241 [KO:K02148]
            100273246  uncharacterized protein LOC100273246 [KO:K02148]
            100193069  V-type proton ATPase subunit D [KO:K02149]
            100283330  uncharacterized protein LOC100283330 [KO:K02149]
            100192065  uncharacterized protein LOC100192065 [KO:K02150]
            100273417  uncharacterized protein LOC100273417 [KO:K02150]
            103651402  V-type proton ATPase subunit E-like [KO:K02150]
            100501172  uncharacterized protein LOC100501172 [KO:K02150]
            100283102  vacuolar ATP synthase subunit F [KO:K02151]
            100283470  vacuolar ATP synthase subunit F [KO:K02151]
            100193359  uncharacterized protein LOC100193359 [KO:K02152]
            100282544  vacuolar ATP synthase subunit G [KO:K02152]
            100275277  uncharacterized protein LOC100275277 precursor [KO:K02153]
            109942225  V-type proton ATPase subunit e1 [KO:K02153]
            100381766  vacuolar proton ATPase a3 [KO:K02154]
            103636525  V-type proton ATPase subunit a1 [KO:K02154]
            103639351  V-type proton ATPase subunit a3 [KO:K02154]
            100280083  uncharacterized protein LOC100280083 [KO:K02146]
            100280574  vacuolar ATPase subunit H protein [KO:K02144]
            103647744  probable V-type proton ATPase subunit H [KO:K02144]
            100280656  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100282032  vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K02155]
            100282817  vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K02155]
            542441  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            100283904  uncharacterized protein LOC100283904 [KO:K02155]
            103652900  V-type proton ATPase 16 kDa proteolipid subunit isoform X2 [KO:K02155]
            103651792  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
            109945998  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
            100285771  uncharacterized protein LOC100285771 [KO:K03661]
            100283291  vacuolar ATP synthase 21 kDa proteolipid subunit [KO:K03661]
            100272622  uncharacterized protein LOC100272622 [KO:K07897]
            100283666  ras-related protein Rab7 [KO:K07897]
            100193973  uncharacterized protein LOC100193973 [KO:K07897]
            100383121  uncharacterized protein LOC100383121 [KO:K07897]
            103642472  ras-related protein Rab7 [KO:K07897]
            103630662  ras-related protein Rab7 [KO:K07897]
            103649123  ras-related protein Rab7-like [KO:K07897]
            109940504  ras-related protein Rab7 [KO:K07897]
            542395  tubulin alpha-3 chain [KO:K07374]
            542582  tubulin alpha-6 chain [KO:K07374]
            542248  tubulin alpha-5 chain [KO:K07374]
            100381303  tubulin alpha-4 chain [KO:K07374]
            100037751  tubulin alpha-1 chain [KO:K07374]
            103643947  tubulin alpha-2 chain [KO:K07374]
            542705  tubulin beta-7 chain [KO:K07375]
            542380  tubulin beta-2 chain [KO:K07375]
            542416  tubulin beta-3 chain [KO:K07375]
            542417  tubulin beta-4 chain [KO:K07375]
            542418  tubulin beta-5 chain [KO:K07375]
            100272336  uncharacterized protein LOC100272336 [KO:K07375]
            103629648  tubulin beta-7 chain-like [KO:K07375]
            100273658  tubulin beta-1 chain [KO:K07375]
            100502086  uncharacterized protein LOC100502086 [KO:K07375]
            100382290  uncharacterized protein LOC100382290 [KO:K07375]
            542239  tubulin beta-6 chain [KO:K07375]
            100383576  uncharacterized protein LOC100383576 [KO:K07375]
            103625832  tubulin beta-7 chain [KO:K07375]
            103644409  tubulin alpha-2 chain [KO:K07375]
            103653230  tubulin beta-1 chain-like [KO:K07375]
            103640974  tubulin beta-7 chain-like [KO:K07375]
            103652102  tubulin beta-1 chain [KO:K07375]
            103636073  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            103628939  1-phosphatidylinositol-3-phosphate 5-kinase FAB1A [KO:K00921] [EC:2.7.1.150]
            103632727  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            103643294  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
            103646184  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D isoform X1 [KO:K00921] [EC:2.7.1.150]
            103650943  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
            100193462  uncharacterized protein LOC100193462 [KO:K00921] [EC:2.7.1.150]
            103653169  1-phosphatidylinositol-3-phosphate 5-kinase FAB1A isoform X1 [KO:K00921] [EC:2.7.1.150]
            103653328  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]
            542482  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
            100280289  uncharacterized protein LOC100280289 [KO:K10956]
            100276798  uncharacterized protein LOC100276798 [KO:K10956]
            100217058  uncharacterized protein LOC100217058 [KO:K10956]
            100280873  protein transport protein Sec61 beta subunit [KO:K09481]
            100285315  protein transport protein Sec61 beta subunit [KO:K09481]
            100286118  protein transport protein Sec61 beta subunit [KO:K09481]
            103651507  protein transport protein Sec61 subunit beta [KO:K09481]
            100280916  protein transport protein SEC61 gamma subunit [KO:K07342]
            100284544  protein transport protein SEC61 gamma subunit [KO:K07342]
            100282298  protein transport protein SEC61 gamma subunit [KO:K07342]
            100192024  uncharacterized protein LOC100192024 [KO:K07342]
            542732  calreticulin precursor [KO:K08057]
            103647314  calreticulin-like [KO:K08057]
            100273288  calreticulin-3 precursor [KO:K08057]
            100382232  uncharacterized protein LOC100382232 precursor [KO:K08057]
            542421  calnexin homolog precursor [KO:K08054]
            100283947  calnexin precursor [KO:K08054]
            542739  Rho-related protein from plants 4 [KO:K04392]
            542758  Rho-related protein from plants 5 [KO:K04392]
            541773  Rho-related protein from plants 1 [KO:K04392]
            541774  Rop3 small GTP binding protein [KO:K04392]
            541930  GTPase protein [KO:K04392]
            542017  rop6 protein [KO:K04392]
            542503  Rho-related protein from plants 7 [KO:K04392]
            542618  Rho-related protein from plants 2 [KO:K04392]
            542094  Rho-related protein from plants 9 [KO:K04392]
COMPOUND    C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
REFERENCE   PMID:15894272
  AUTHORS   Stuart LM, Ezekowitz RA
  TITLE     Phagocytosis: elegant complexity.
  JOURNAL   Immunity 22:539-50 (2005)
            DOI:10.1016/j.immuni.2005.05.002
REFERENCE   PMID:10684585
  AUTHORS   Tjelle TE, Lovdal T, Berg T
  TITLE     Phagosome dynamics and function.
  JOURNAL   Bioessays 22:255-63 (2000)
            DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
REFERENCE   PMID:18492791
  AUTHORS   Dupuy AG, Caron E
  TITLE     Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  JOURNAL   J Cell Sci 121:1773-83 (2008)
            DOI:10.1242/jcs.018036
REFERENCE   PMID:15036145
  AUTHORS   Brumell JH, Grinstein S
  TITLE     Salmonella redirects phagosomal maturation.
  JOURNAL   Curr Opin Microbiol 7:78-84 (2004)
            DOI:10.1016/j.mib.2003.12.005
REFERENCE   PMID:17245426
  AUTHORS   Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  TITLE     LAMP proteins are required for fusion of lysosomes with phagosomes.
  JOURNAL   EMBO J 26:313-24 (2007)
            DOI:10.1038/sj.emboj.7601511
REFERENCE   PMID:17637737
  AUTHORS   Luzio JP, Pryor PR, Bright NA
  TITLE     Lysosomes: fusion and function.
  JOURNAL   Nat Rev Mol Cell Biol 8:622-32 (2007)
            DOI:10.1038/nrm2217
REFERENCE   PMID:18513324
  AUTHORS   Sumimoto H
  TITLE     Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  JOURNAL   FEBS J 275:3249-77 (2008)
            DOI:10.1111/j.1742-4658.2008.06488.x
REL_PATHWAY zma04144  Endocytosis
KO_PATHWAY  ko04145
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