ENTRY       zma04144                    Pathway
NAME        Endocytosis - Zea mays (maize)
DESCRIPTION Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
CLASS       Cellular Processes; Transport and catabolism
PATHWAY_MAP zma04144  Endocytosis
DBLINKS     GO: 0006897
ORGANISM    Zea mays (maize) [GN:zma]
GENE        103643864  phosphatidylinositol 4-phosphate 5-kinase 1 [KO:K00889] [EC:2.7.1.68]
            100281652  uncharacterized protein LOC100281652 [KO:K00889] [EC:2.7.1.68]
            100304265  uncharacterized protein LOC100304265 [KO:K00889] [EC:2.7.1.68]
            100216938  uncharacterized protein LOC100216938 [KO:K00889] [EC:2.7.1.68]
            103647104  phosphatidylinositol 4-phosphate 5-kinase 6 [KO:K00889] [EC:2.7.1.68]
            103626132  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
            103643394  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
            103643872  phosphatidylinositol 4-phosphate 5-kinase 2 isoform X1 [KO:K00889] [EC:2.7.1.68]
            103635048  phosphatidylinositol 4-phosphate 5-kinase 6 isoform X1 [KO:K00889] [EC:2.7.1.68]
            100381628  uncharacterized protein LOC100381628 [KO:K00889] [EC:2.7.1.68]
            100383415  uncharacterized protein LOC100383415 [KO:K00889] [EC:2.7.1.68]
            100280155  phospholipase D family protein [KO:K01115] [EC:3.1.4.4]
            542702  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
            100501678  uncharacterized protein LOC100501678 [KO:K01115] [EC:3.1.4.4]
            103647321  phospholipase D delta isoform X1 [KO:K01115] [EC:3.1.4.4]
            103647629  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
            103647433  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
            100217111  phospholipase D family protein [KO:K01115] [EC:3.1.4.4]
            100272416  phospholipase D family protein [KO:K01115] [EC:3.1.4.4]
            103630082  phospholipase D alpha 1 isoform X2 [KO:K01115] [EC:3.1.4.4]
            103630236  phospholipase D zeta 1 isoform X1 [KO:K01115] [EC:3.1.4.4]
            103630917  phospholipase D beta 1 [KO:K01115] [EC:3.1.4.4]
            100279815  phospholipase D family protein [KO:K01115] [EC:3.1.4.4]
            103626543  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
            100280265  phospholipase D family protein [KO:K01115] [EC:3.1.4.4]
            118473389  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
            100286124  dynamin-2A [KO:K01528] [EC:3.6.5.5]
            103627697  dynamin-2A [KO:K01528] [EC:3.6.5.5]
            103643299  dynamin-2A [KO:K01528] [EC:3.6.5.5]
            103637796  dynamin-2A [KO:K01528] [EC:3.6.5.5]
            100193501  uncharacterized protein LOC100193501 [KO:K04646]
            103640647  clathrin heavy chain 1 [KO:K04646]
            103652644  clathrin heavy chain 1 [KO:K04646]
            103654268  clathrin heavy chain 1 [KO:K04646]
            100384187  AP-2 complex subunit alpha-2 [KO:K11824]
            100280063  AP-2 complex subunit alpha-2 [KO:K11824]
            100283476  uncharacterized protein LOC100283476 [KO:K11826]
            100281988  AP-2 complex subunit sigma [KO:K11827]
            103650611  uncharacterized protein LOC103650611 [KO:K11827]
            100277273  uncharacterized protein LOC100277273 [KO:K12471]
            100501876  uncharacterized protein LOC100501876 [KO:K12471]
            103653240  ENTH domain-containing protein C794.11c [KO:K12471]
            103654150  clathrin interactor EPSIN 2 [KO:K12471]
            541647  physical impedance induced protein 2 [KO:K19366]
            100191434  uncharacterized protein LOC100191434 [KO:K19366]
            103633595  actin-related protein 2 [KO:K17260]
            100192466  uncharacterized protein LOC100192466 [KO:K18584]
            100281262  uncharacterized protein LOC100281262 [KO:K18584]
            103629061  actin-related protein 3 [KO:K18584]
            100384280  uncharacterized protein LOC100384280 [KO:K18584]
            100281189  uncharacterized protein LOC100281189 [KO:K18584]
            100282667  actin-related protein 2/3 complex subunit 1B [KO:K05757]
            100384689  Actin-related protein 2/3 complex subunit 1A [KO:K05757]
            100282664  uncharacterized protein LOC100282664 [KO:K05758]
            103646223  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2B [KO:K05758]
            100216873  actin protein 2/3 complex subunit 3 [KO:K05756]
            103627019  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
            103627016  actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
            103632067  actin-related protein 2/3 complex subunit 3 [KO:K05756]
            103627023  actin-related protein 2/3 complex subunit 3 [KO:K05756]
            103651116  actin-related protein 2/3 complex subunit 3 [KO:K05756]
            103628540  actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
            118471909  actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
            100286207  uncharacterized protein LOC100286207 [KO:K05755]
            100383074  actin-related protein 2/3 complex subunit 5A [KO:K05754]
            103625973  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
            100277908  uncharacterized LOC100277908 [KO:K03283]
            100272911  uncharacterized protein LOC100272911 [KO:K03283]
            100280354  uncharacterized protein LOC100280354 [KO:K03283]
            100281806  heat shock cognate 70 kDa protein 2 [KO:K03283]
            100286168  stromal 70 kDa heat shock-related protein [KO:K03283]
            100501536  heat shock protein 1 [KO:K03283]
            103650436  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
            103650526  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
            103639924  heat shock 70 kDa protein 4 [KO:K03283]
            103635762  heat shock 70 kDa protein [KO:K03283]
            103652717  heat shock cognate 70 kDa protein 2 isoform X1 [KO:K03283]
            103634464  heat shock cognate 70 kDa protein [KO:K03283]
            103651028  heat shock 70 kDa protein-like [KO:K03283]
            100273564  uncharacterized protein LOC100273564 [KO:K10364]
            100285122  F-actin capping protein alpha subunit [KO:K10364]
            100193381  uncharacterized protein LOC100193381 [KO:K10365]
            100192764  uncharacterized protein LOC100192764 [KO:K18467]
            100281359  vacuolar protein sorting 29 [KO:K18467]
            100193449  vacuolar protein sorting 26 [KO:K18466]
            100282332  uncharacterized protein LOC100282332 [KO:K18466]
            100285267  vacuolar protein sorting 35 [KO:K18468]
            100279276  uncharacterized protein LOC100279276 [KO:K18468]
            100191225  uncharacterized protein LOC100191225 [KO:K11866] [EC:3.4.19.12]
            103650155  AMSH-like ubiquitin thioesterase 3 isoform X1 [KO:K11866] [EC:3.4.19.12]
            100283490  mov34/MPN/PAD-1 family protein [KO:K11866] [EC:3.4.19.12]
            100284313  mov34/MPN/PAD-1 family protein [KO:K11866] [EC:3.4.19.12]
            100272622  uncharacterized protein LOC100272622 [KO:K07897]
            100283666  ras-related protein Rab7 [KO:K07897]
            100193973  uncharacterized protein LOC100193973 [KO:K07897]
            100383121  uncharacterized protein LOC100383121 [KO:K07897]
            103642472  ras-related protein Rab7 [KO:K07897]
            103630662  ras-related protein Rab7 [KO:K07897]
            103649123  ras-related protein Rab7-like [KO:K07897]
            109940504  ras-related protein Rab7 [KO:K07897]
            100304271  uncharacterized protein LOC100304271 [KO:K12183]
            100275829  uncharacterized protein LOC100275829 [KO:K12183]
            100284642  VPS28-like protein [KO:K12184]
            103651140  vacuolar protein sorting-associated protein 28 homolog 1 [KO:K12184]
            100272263  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
            100284677  uncharacterized protein LOC100284677 [KO:K12185]
            100216977  uncharacterized protein LOC100216977 [KO:K12188]
            100191871  uncharacterized protein LOC100191871 [KO:K12190]
            103651086  vacuolar protein sorting-associated protein 36 [KO:K12190]
            100283903  vacuolar protein sorting protein 25 [KO:K12189]
            100216677  uncharacterized protein LOC100216677 [KO:K12195]
            100272755  uncharacterized protein LOC100272755 [KO:K12195]
            100191382  Vacuolar protein sorting-associated protein 32 homolog 1 [KO:K12194]
            100281033  charged multivesicular body protein 4b [KO:K12194]
            103654298  uncharacterized protein LOC103654298 [KO:K12194]
            100191358  uncharacterized protein LOC100191358 [KO:K12194]
            100286131  charged multivesicular body protein 4b [KO:K12194]
            100216894  uncharacterized protein LOC100216894 [KO:K12193]
            100273289  uncharacterized protein LOC100273289 [KO:K12193]
            100193992  uncharacterized protein LOC100193992 [KO:K12191]
            103647208  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
            100284688  charged multivesicular body protein 2a [KO:K12191]
            100284170  charged multivesicular body protein 2a [KO:K12191]
            100282251  uncharacterized protein LOC100282251 [KO:K12192]
            100274253  uncharacterized protein LOC100274253 [KO:K15053]
            100283774  vacuolar sorting protein 4b [KO:K12196]
            103634814  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
            100276474  uncharacterized protein LOC100276474 [KO:K12199]
            103638323  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
            542116  superal 1 [KO:K12197]
            100284928  uncharacterized protein LOC100284928 [KO:K12198]
            100273036  uncharacterized protein LOC100273036 [KO:K12198]
            100285833  vacuolar protein-sorting protein bro1 [KO:K12200]
            100383198  uncharacterized protein LOC100383198 [KO:K12200]
            100286189  ALG2-interacting protein X [KO:K12200]
            100284261  maspardin [KO:K19367]
            103650974  sorting nexin 1-like [KO:K17917]
            100194251  uncharacterized protein LOC100194251 [KO:K17917]
            100191530  uncharacterized protein LOC100191530 [KO:K07889]
            100193933  ras-related protein RABF2a [KO:K07889]
            103631302  ras-related protein Rab5A [KO:K07889]
            103640217  ras-related protein Rab5A [KO:K07889]
            103643941  late embryogenesis abundant protein 19 [KO:K07889]
            100384394  uncharacterized protein LOC100384394 [KO:K12483]
            100272658  uncharacterized protein LOC100272658 [KO:K12483]
            100381653  uncharacterized protein LOC100381653 [KO:K12483]
            100286026  uncharacterized protein LOC100286026 [KO:K12479]
            100273222  Ras protein ARA-3 [KO:K07901]
            100273382  uncharacterized protein LOC100273382 [KO:K07901]
            100192989  uncharacterized protein LOC100192989 [KO:K07901]
            103632090  ras-related protein RABE1e-like [KO:K07901]
            100282517  uncharacterized protein LOC100282517 isoform 1 [KO:K07901]
            103649028  ras-related protein RABE1c-like [KO:K07901]
            103644714  ras-related protein RABE1c [KO:K07901]
            103635765  ras-related protein RABE1c [KO:K07901]
            103643924  ras-related protein RABE1c-like [KO:K07901]
            103639686  ras-related protein RABE1c-like [KO:K07901]
            100272423  ras-related protein ARA-3 [KO:K07901]
            100502497  uncharacterized protein LOC100502497 [KO:K07901]
            100191168  uncharacterized protein LOC100191168 [KO:K07904]
            100193158  uncharacterized LOC100193158 [KO:K07904]
            100192685  uncharacterized protein LOC100192685 [KO:K07904]
            100216670  Ras-related protein RABA2c [KO:K07904]
            100193335  Ras protein Rab11A [KO:K07904]
            100282310  uncharacterized protein LOC100282310 [KO:K07904]
            100281941  uncharacterized protein LOC100281941 [KO:K07904]
            100280532  uncharacterized protein LOC100280532 [KO:K07904]
            100280470  uncharacterized protein LOC100280470 [KO:K07904]
            100283582  uncharacterized protein LOC100283582 [KO:K07904]
            100286011  uncharacterized protein LOC100286011 [KO:K07904]
            100285194  ras-related protein Rab11D [KO:K07904]
            100272235  uncharacterized protein LOC100272235 [KO:K07904]
            100285596  ras-related protein Rab11A [KO:K07904]
            100283324  ras-related protein Rab11C [KO:K07904]
            103626451  ras-related protein RABA3 [KO:K07904]
            100283230  uncharacterized protein LOC100283230 [KO:K07904]
            100193344  uncharacterized protein LOC100193344 [KO:K07904]
            100194331  Ras protein RIC2 [KO:K07904]
            100381498  uncharacterized protein LOC100381498 [KO:K07904]
            100279063  uncharacterized protein LOC100279063 [KO:K07904]
            100279757  uncharacterized protein LOC100279757 [KO:K12486]
            103628471  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12486]
            100193084  uncharacterized protein LOC100193084 [KO:K12486]
            103637829  probable ADP-ribosylation factor GTPase-activating protein AGD13 [KO:K12486]
            100216740  uncharacterized protein LOC100216740 [KO:K12486]
            100381421  uncharacterized protein LOC100381421 [KO:K12486]
            100283383  uncharacterized protein LOC100283383 [KO:K12486]
            100382772  putative calcium-dependent lipid-binding (CaLB domain) family protein [KO:K12486]
            100272989  putative calcium-dependent lipid-binding (CaLB domain) family protein [KO:K12486]
            100273517  putative calcium-dependent lipid-binding (CaLB domain) family protein [KO:K12486]
            103655231  ADP-ribosylation factor GTPase-activating protein AGD1-like [KO:K12486]
            109943148  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12486]
            100383138  putative ARF GTPase activating domain protein with ankyrin repeat-containing protein [KO:K12489]
            103632959  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
            103653236  ADP-ribosylation factor GTPase-activating protein AGD3 isoform X1 [KO:K12489]
            100383867  uncharacterized protein LOC100383867 [KO:K12489]
            100284393  uncharacterized protein LOC100284393 [KO:K12492]
            103634469  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
            100191606  putative ARF GTPase-activating domain family protein [KO:K12493]
            100216842  putative ARF GTPase-activating domain family protein [KO:K12493]
            100283451  ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
            103637695  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
            100857099  guanine-nucleotide-exchange protein [KO:K18442]
            103638791  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
            103654846  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
            103637660  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
            103626007  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
            109942339  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
            103652202  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
            100382775  uncharacterized protein LOC100382775 [KO:K07937]
            103627567  ADP-ribosylation factor 1 isoform X1 [KO:K07937]
            103640874  ADP-ribosylation factor 1 [KO:K07937]
            100280562  ADP-ribosylation factor 1 [KO:K07937]
            100282739  ADP-ribosylation factor [KO:K07937]
            100216623  uncharacterized protein LOC100216623 [KO:K07937]
            100384428  uncharacterized protein LOC100384428 [KO:K07937]
            732812  ADP-ribosylation factor [KO:K07937]
            100280918  ADP-ribosylation factor 1 [KO:K07937]
            103637862  ADP-ribosylation factor isoform X1 [KO:K07937]
            100192472  uncharacterized protein LOC100192472 [KO:K07937]
            100381426  uncharacterized protein LOC100381426 isoform variant [KO:K07937]
            100284295  ADP-ribosylation factor [KO:K07937]
            100192068  uncharacterized protein LOC100192068 isoform 2 [KO:K07937]
COMPOUND    C00035  GDP
            C00044  GTP
            C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
            C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
            C05981  Phosphatidylinositol-3,4,5-trisphosphate
            C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
REFERENCE   PMID:19007773
  AUTHORS   Acconcia F, Sigismund S, Polo S
  TITLE     Ubiquitin in trafficking: the network at work.
  JOURNAL   Exp Cell Res 315:1610-8 (2009)
            DOI:10.1016/j.yexcr.2008.10.014
REFERENCE   PMID:18647649
  AUTHORS   Donaldson JG, Porat-Shliom N, Cohen LA
  TITLE     Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  JOURNAL   Cell Signal 21:1-6 (2009)
            DOI:10.1016/j.cellsig.2008.06.020
REFERENCE   PMID:15261671
  AUTHORS   Sorkin A
  TITLE     Cargo recognition during clathrin-mediated endocytosis: a team effort.
  JOURNAL   Curr Opin Cell Biol 16:392-9 (2004)
            DOI:10.1016/j.ceb.2004.06.001
REFERENCE   PMID:19325624
  AUTHORS   Raiborg C, Stenmark H
  TITLE     The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  JOURNAL   Nature 458:445-52 (2009)
            DOI:10.1038/nature07961
REFERENCE   PMID:20110990
  AUTHORS   Scita G, Di Fiore PP
  TITLE     The endocytic matrix.
  JOURNAL   Nature 463:464-73 (2010)
            DOI:10.1038/nature08910
REFERENCE   PMID:15687999
  AUTHORS   Le Roy C, Wrana JL
  TITLE     Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  JOURNAL   Nat Rev Mol Cell Biol 6:112-26 (2005)
            DOI:10.1038/nrm1571
REFERENCE   PMID:19924646
  AUTHORS   Jovic M, Sharma M, Rahajeng J, Caplan S
  TITLE     The early endosome: a busy sorting station for proteins at the crossroads.
  JOURNAL   Histol Histopathol 25:99-112 (2010)
            DOI:10.14670/HH-25.99
REFERENCE   PMID:16203612
  AUTHORS   Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  TITLE     Viral entry, lipid rafts and caveosomes.
  JOURNAL   Ann Med 37:394-403 (2005)
            DOI:10.1080/07853890510011976
REFERENCE   PMID:19696797
  AUTHORS   Grant BD, Donaldson JG
  TITLE     Pathways and mechanisms of endocytic recycling.
  JOURNAL   Nat Rev Mol Cell Biol 10:597-608 (2009)
            DOI:10.1038/nrm2755
REFERENCE   PMID:22193161
  AUTHORS   Cullen PJ, Korswagen HC
  TITLE     Sorting nexins provide diversity for retromer-dependent trafficking events.
  JOURNAL   Nat Cell Biol 14:29-37 (2012)
            DOI:10.1038/ncb2374
REL_PATHWAY zma04070  Phosphatidylinositol signaling system
            zma04130  SNARE interactions in vesicular transport
KO_PATHWAY  ko04144
///
