ENTRY       zma04120                    Pathway
NAME        Ubiquitin mediated proteolysis - Zea mays (maize)
DESCRIPTION Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP zma04120  Ubiquitin mediated proteolysis
DBLINKS     GO: 0016567
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100282068  uncharacterized protein LOC100282068 [KO:K08770]
            100283898  uncharacterized protein LOC100283898 [KO:K08770]
            100284418  Ubiquitin-60S ribosomal protein L40-like [KO:K02927]
            103647262  ubiquitin-60S ribosomal protein L40-1 [KO:K02927]
            103633191  ubiquitin [KO:K02927]
            103633247  ubiquitin-60S ribosomal protein L40-1 isoform X1 [KO:K02927]
            103633261  ubiquitin-60S ribosomal protein L40-1 [KO:K02927]
            100192952  Ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
            100282479  40S ribosomal protein S27a-like [KO:K02977]
            100284333  ubiquitin-40S ribosomal protein S27a [KO:K02977]
            101027200  ubiquitin-40S ribosomal protein S27a [KO:K02977]
            100277387  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
            103647693  ubiquitin [KO:K02977]
            100279472  uncharacterized protein LOC100279472 [KO:K03178] [EC:6.2.1.45]
            103633603  ubiquitin-activating enzyme E1 3 isoform X1 [KO:K03178] [EC:6.2.1.45]
            103634508  ubiquitin-activating enzyme E1 3 isoform X1 [KO:K03178] [EC:6.2.1.45]
            100381933  uncharacterized protein LOC100381933 [KO:K03178] [EC:6.2.1.45]
            100382860  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
            100284284  uncharacterized protein LOC100284284 [KO:K10684] [EC:6.2.1.45]
            100278764  uncharacterized protein LOC100278764 [KO:K10685] [EC:6.2.1.45]
            103647788  SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
            100283559  uncharacterized protein LOC100283559 [KO:K10686] [EC:6.2.1.64]
            100193988  uncharacterized protein LOC100193988 [KO:K10573] [EC:2.3.2.23]
            100280476  ubiquitin-conjugating enzyme E2-17 kDa [KO:K10573] [EC:2.3.2.23]
            100283749  uncharacterized protein LOC100283749 [KO:K10573] [EC:2.3.2.23]
            100284762  uncharacterized protein LOC100284762 [KO:K10573] [EC:2.3.2.23]
            100192052  uncharacterized protein LOC100192052 [KO:K10573] [EC:2.3.2.23]
            100192735  putative ubiquitin-conjugating enzyme family [KO:K06688] [EC:2.3.2.23]
            100283079  ubiquitin-conjugating enzyme X [KO:K06688] [EC:2.3.2.23]
            103651070  uncharacterized protein LOC103651070 [KO:K06689] [EC:2.3.2.23]
            100286223  uncharacterized protein LOC100286223 [KO:K06689] [EC:2.3.2.23]
            541665  ubiquitin conjugating enzyme [KO:K06689] [EC:2.3.2.23]
            100281830  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
            100192813  uncharacterized protein LOC100192813 [KO:K06689] [EC:2.3.2.23]
            100280571  uncharacterized protein LOC100280571 [KO:K06689] [EC:2.3.2.23]
            100192684  putative ubiquitin-conjugating enzyme family [KO:K06689] [EC:2.3.2.23]
            100285413  uncharacterized protein LOC100285413 [KO:K06689] [EC:2.3.2.23]
            100280942  ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
            541984  Ubiquitin carrier protein [KO:K10575] [EC:2.3.2.23]
            542600  ubiquitin-conjugating enzyme protein E2 [KO:K10575] [EC:2.3.2.23]
            100272466  uncharacterized protein LOC100272466 [KO:K10575] [EC:2.3.2.23]
            100283106  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
            100193596  uncharacterized protein LOC100193596 [KO:K10576] [EC:2.3.2.23]
            100194405  putative ubiquitin-conjugating enzyme family [KO:K10576] [EC:2.3.2.23]
            101202716  putative ubiquitin-conjugating enzyme family [KO:K10576] [EC:2.3.2.23]
            100857003  ubiquitin-conjugating enzyme E2-21 kDa 1 [KO:K10576] [EC:2.3.2.23]
            115565779  ubiquitin-conjugating enzyme family [KO:K10576] [EC:2.3.2.23]
            100282735  ubiquitin-conjugating enzyme E2 I [KO:K10577]
            103646037  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100283731  SUMO-conjugating enzyme SCE1 [KO:K10577]
            103637558  SUMO-conjugating enzyme SCE1 [KO:K10577]
            103639085  SUMO-conjugating enzyme SCE1 [KO:K10577]
            100280784  uncharacterized protein LOC100280784 [KO:K10577]
            100304088  ubiquitin-conjugating enzyme E2 I [KO:K10577]
            103634565  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
            100284401  uncharacterized protein LOC100284401 [KO:K10578] [EC:2.3.2.23]
            100193789  uncharacterized protein LOC100193789 [KO:K04554] [EC:2.3.2.23]
            100283253  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
            103656052  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            103644970  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
            542170  putative ubiquitin-conjugating enzyme family [KO:K10579] [EC:2.3.2.34]
            100286302  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
            100272559  putative ubiquitin-conjugating enzyme family [KO:K10580] [EC:2.3.2.23]
            100281972  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
            103651370  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
            101202705  putative ubiquitin-conjugating enzyme family [KO:K10580] [EC:2.3.2.23]
            100304369  uncharacterized protein LOC100304369 [KO:K10581] [EC:2.3.2.24]
            100502472  uncharacterized protein LOC100502472 [KO:K10581] [EC:2.3.2.24]
            103630718  ubiquitin-conjugating enzyme E2 [KO:K10581] [EC:2.3.2.24]
            100384586  uncharacterized protein LOC100384586 [KO:K10581] [EC:2.3.2.24]
            103651829  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
            100194284  uncharacterized protein LOC100194284 [KO:K10581] [EC:2.3.2.24]
            100502171  uncharacterized protein LOC100502171 [KO:K10581] [EC:2.3.2.24]
            100194137  uncharacterized protein LOC100194137 [KO:K10583] [EC:2.3.2.23]
            100384009  uncharacterized protein LOC100384009 [KO:K10583] [EC:2.3.2.23]
            100272309  ubiquitin conjugating enzyme 1 [KO:K10688] [EC:2.3.2.25]
            100280549  ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.25]
            100282569  uncharacterized protein LOC100282569 [KO:K10688] [EC:2.3.2.25]
            100193523  uncharacterized protein LOC100193523 [KO:K10688] [EC:2.3.2.25]
            100283953  ubiquitin-conjugating enzyme E2-22 kDa [KO:K04649] [EC:2.3.2.23]
            103625986  E3 ubiquitin-protein ligase UPL7 isoform X2 [KO:K10588] [EC:2.3.2.26]
            100502346  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
            103641081  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
            103646651  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
            103626504  uncharacterized protein LOC103626504 [KO:K10590] [EC:2.3.2.26]
            103635779  E3 ubiquitin-protein ligase UPL4 isoform X1 [KO:K10590] [EC:2.3.2.26]
            103630940  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
            103630958  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
            103639061  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            103636597  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
            100273449  uncharacterized protein LOC100273449 [KO:K09561] [EC:2.3.2.27]
            100282870  STIP1 homology and U box-containing protein 1 [KO:K09561] [EC:2.3.2.27]
            103632256  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
            100191855  uncharacterized protein LOC100191855 [KO:K10599] [EC:2.3.2.27]
            100284255  pre-mRNA-splicing factor 19 [KO:K10599] [EC:2.3.2.27]
            100170242  uncharacterized protein LOC100170242 [KO:K04506] [EC:2.3.2.27]
            100170244  uncharacterized protein LOC100170244 [KO:K04506] [EC:2.3.2.27]
            100170245  uncharacterized protein LOC100170245 [KO:K04506] [EC:2.3.2.27]
            100273809  Ubiquitin-protein ligase/ zinc ion binding protein [KO:K04506] [EC:2.3.2.27]
            100279741  uncharacterized protein LOC100279741 [KO:K04506] [EC:2.3.2.27]
            103626898  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
            100284602  ubiquitin-protein ligase/ zinc ion binding protein [KO:K04506] [EC:2.3.2.27]
            100170243  uncharacterized protein LOC100170243 [KO:K04506] [EC:2.3.2.27]
            103634779  E3 ubiquitin-protein ligase SINA-like 5 [KO:K04506] [EC:2.3.2.27]
            100279342  uncharacterized protein LOC100279342 [KO:K10143] [EC:2.3.2.27]
            100286122  ubiquitin ligase protein COP1 [KO:K10143] [EC:2.3.2.27]
            100192089  uncharacterized protein LOC100192089 isoform 2 [KO:K10144] [EC:2.3.2.27]
            100192978  uncharacterized protein LOC100192978 [KO:K10144] [EC:2.3.2.27]
            100282790  RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
            100272854  putative RING zinc finger domain superfamily protein [KO:K10144] [EC:2.3.2.27]
            100280509  RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
            100217275  uncharacterized protein LOC100217275 [KO:K04706] [EC:2.3.2.-]
            100217233  uncharacterized protein LOC100217233 [KO:K10601] [EC:2.3.2.27]
            100384282  uncharacterized protein LOC100384282 [KO:K10601] [EC:2.3.2.27]
            100192745  ubiquitin ligase protein FANCL [KO:K10606] [EC:2.3.2.27]
            100192928  uncharacterized protein LOC100192928 [KO:K03868] [EC:2.3.2.32]
            103634739  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
            103649912  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            103641392  cullin-1 isoform X1 [KO:K03347]
            103635893  cullin-1-like [KO:K03347]
            100193107  uncharacterized protein LOC100193107 [KO:K03094]
            103649432  SKP1-like protein 1 [KO:K03094]
            100282249  SKP1-like protein 1B [KO:K03094]
            100280388  uncharacterized protein LOC100280388 [KO:K03094]
            100283299  uncharacteriized protein LOC100283299 [KO:K03094]
            100286031  SKP1-like protein 1A [KO:K03094]
            100285914  uncharacterized protein LOC100285914 [KO:K03094]
            103648145  SKP1-like protein 1 [KO:K03094]
            103648149  SKP1-like protein 1 [KO:K03094]
            103648178  SKP1-like protein 1 [KO:K03094]
            103647870  SKP1-like protein 1A [KO:K03094]
            103628765  SKP1-like protein 1 [KO:K03094]
            103649426  SKP1-like protein 1 [KO:K03094]
            103652383  SKP1-like protein 1 [KO:K03094]
            118474115  SKP1-like protein 1 [KO:K03094]
            118476267  SKP1-like protein 1 [KO:K03094]
            100274332  uncharacterized protein LOC100274332 [KO:K03875]
            100274363  uncharacterized protein LOC100274363 [KO:K03875]
            100282398  uncharacterized protein LOC100282398 [KO:K03872]
            100283809  uncharacterized protein LOC100283809 [KO:K03872]
            100384196  uncharacterized protein LOC100384196 [KO:K03869]
            103627724  cullin-3A [KO:K03869]
            103641219  cullin-3A isoform X1 [KO:K03869]
            100501431  uncharacterized protein LOC100501431 [KO:K10609]
            103625822  cullin-4 [KO:K10609]
            100279448  uncharacterized protein LOC100279448 [KO:K10610]
            103635427  DNA damage-binding protein 1 [KO:K10610]
            100381699  DNA damage-binding protein 2 [KO:K10140]
            100275606  uncharacterized protein LOC100275606 [KO:K10570]
            100281541  light-mediated development protein DET1 [KO:K10571]
            100273813  uncharacterized protein LOC100273813 [KO:K10571]
            100283699  uncharacterized protein LOC100283699 [KO:K03358]
            103626410  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
            100285215  cell division cycle protein 20 [KO:K03363]
            100384140  uncharacterized protein LOC100384140 [KO:K03363]
            100193750  uncharacterized protein LOC100193750 [KO:K03364]
            100384147  uncharacterized protein LOC100384147 [KO:K03364]
            103631177  protein FIZZY-RELATED 2 [KO:K03364]
            103631492  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
            100192791  uncharacterized protein LOC100192791 [KO:K03350]
            100304372  uncharacterized protein LOC100304372 [KO:K03351]
            100279215  uncharacterized protein LOC100279215 [KO:K03352]
            100273613  putative tetratricopeptide repeat domain containing family protein [KO:K03353]
            103639381  anaphase-promoting complex subunit 6 isoform X1 [KO:K03353]
            100280734  cell division cycle protein 23 [KO:K03355]
            100282264  anaphase-promoting complex subunit 10 [KO:K03357]
            100502261  uncharacterized protein LOC100502261 [KO:K03357]
            100193267  uncharacterized protein LOC100193267 [KO:K12456]
REFERENCE   PMID:16922370
  AUTHORS   Kamura T.
  TITLE     [Cullin-based E3 family]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
REFERENCE   PMID:16922408
  AUTHORS   Matsuda N.
  TITLE     [Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
REFERENCE   PMID:16922367
  AUTHORS   Tokunaga F.
  TITLE     [E2 ubiquitin-conjugating enzymes: structures and functions]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
REFERENCE   PMID:16816840
  AUTHORS   Nalepa G, Rolfe M, Harper JW.
  TITLE     Drug discovery in the ubiquitin-proteasome system.
  JOURNAL   Nat Rev Drug Discov 5:596-613 (2006)
            DOI:10.1038/nrd2056
REFERENCE   PMID:16405856
  AUTHORS   Hsu YJ, Goodman SR.
  TITLE     Spectrin and ubiquitination: a review.
  JOURNAL   Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
REFERENCE   PMID:12944364
  AUTHORS   Hatakeyama S, Nakayama KI.
  TITLE     Ubiquitylation as a quality control system for intracellular proteins.
  JOURNAL   J Biochem 134:1-8 (2003)
            DOI:10.1093/jb/mvg106
REFERENCE   PMID:17588513
  AUTHORS   Lee J, Zhou P.
  TITLE     DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  JOURNAL   Mol Cell 26:775-80 (2007)
            DOI:10.1016/j.molcel.2007.06.001
REL_PATHWAY zma03050  Proteasome
KO_PATHWAY  ko04120
///
