ENTRY       zma03440                    Pathway
NAME        Homologous recombination - Zea mays (maize)
DESCRIPTION Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP zma03440  Homologous recombination
DBLINKS     GO: 0000724
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100285474  single-stranded DNA-binding protein [KO:K03111]
            100191367  uncharacterized protein LOC100191367 [KO:K03553]
            100384162  putative recA DNA recombination family protein [KO:K03553]
            100282426  protein recA [KO:K03553]
            103642101  DNA polymerase I A, chloroplastic [KO:K02335] [EC:2.7.7.7]
            103641202  DNA polymerase I A, chloroplastic isoform X1 [KO:K02335] [EC:2.7.7.7]
            103627634  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:5.6.2.4]
            103653563  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
            100125648  Mre11B protein [KO:K10865]
            100285133  double-strand break repair protein MRE11 [KO:K10865]
            103651852  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
            103630583  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
            100273997  uncharacterized protein LOC100273997 [KO:K10683]
            100281664  ATBRCA1 [KO:K10683]
            103633141  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
            103646962  DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
            103634545  BRCT domain-containing protein At4g02110 isoform X1 [KO:K10728]
            100216554  uncharacterized protein LOC100216554 [KO:K10728]
            100193132  uncharacterized protein LOC100193132 [KO:K20776]
            100282640  protein BRE [KO:K12173]
            100283593  mov34/MPN/PAD-1 family protein [KO:K11864] [EC:3.4.19.-]
            103641455  protein BREAST CANCER SUSCEPTIBILITY 2 homolog A isoform X1 [KO:K08775]
            100280804  deleted in split hand/splt foot protein 1 [KO:K10881]
            100285717  uncharacterized protein LOC100285717 [KO:K10881]
            100285427  uncharacterized protein LOC100285427 [KO:K07466]
            100383373  uncharacterized protein LOC100383373 [KO:K07466]
            100280726  uncharacterized protein LOC100280726 [KO:K07466]
            100273584  Replication protein A DNA-binding subunit [KO:K07466]
            100285013  OB-fold nucleic acid binding domain containing protein [KO:K10739]
            100285903  OB-fold nucleic acid binding domain containing protein [KO:K10739]
            100272286  uncharacterized protein LOC100272286 [KO:K10739]
            103627452  replication protein A 32 kDa subunit B isoform X1 [KO:K10739]
            100283481  uncharacterized protein LOC100283481 [KO:K10740]
            100126965  uncharacterized protein LOC100126965 [KO:K10740]
            100285910  uncharacterized protein LOC100285910 [KO:K10740]
            541709  DNA repair protein RAD51 homolog A [KO:K04482]
            541710  DNA repair protein RAD51 homolog B [KO:K04482]
            100193464  uncharacterized protein LOC100193464 [KO:K10869]
            100284087  DNA repair protein RAD51 [KO:K10870]
            100282783  uncharacterized protein LOC100282783 [KO:K10871]
            100383265  uncharacterized protein LOC100383265 [KO:K10879]
            103627300  DNA repair protein XRCC3 homolog [KO:K10880]
            103627774  DNA repair and recombination protein RAD54 [KO:K10875] [EC:5.6.2.-]
            103641317  protein CHROMATIN REMODELING 35 isoform X1 [KO:K10875] [EC:5.6.2.-]
            103630322  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
            103633601  SNF2 domain-containing protein CLASSY 1 isoform X1 [KO:K10875] [EC:5.6.2.-]
            103653855  SNF2 domain-containing protein CLASSY 3 [KO:K10875] [EC:5.6.2.-]
            100277391  protein CHROMATIN REMODELING 35 isoform X1 [KO:K10875] [EC:5.6.2.-]
            103654581  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100382167  uncharacterized protein LOC100382167 [KO:K02328]
            100194011  uncharacterized protein LOC100194011 [KO:K03504]
            100279971  uncharacterized protein LOC100279971 [KO:K03504]
            103642327  uncharacterized protein LOC103642327 [KO:K03504]
            100282638  uncharacterized protein LOC100282638 [KO:K03505]
            100280534  delta DNA polymerase [KO:K03505]
            100280239  ATP-dependent DNA helicase Q-like [KO:K10901] [EC:5.6.2.4]
            100274706  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
            100383032  DNA topoisomerase 3-beta isoform X3 [KO:K03165] [EC:5.6.2.1]
            100273582  uncharacterized protein LOC100273582 [KO:K03165] [EC:5.6.2.1]
            100216934  crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
            103650756  crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
            103645850  crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
REFERENCE   PMID:18086882
  AUTHORS   Maloisel L, Fabre F, Gangloff S.
  TITLE     DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  JOURNAL   Mol Cell Biol 28:1373-82 (2008)
            DOI:10.1128/MCB.01651-07
REFERENCE   PMID:17571595
  AUTHORS   Haruta-Takahashi N, Iwasaki H.
  TITLE     [Recombination mediators]
  JOURNAL   Seikagaku 79:449-53 (2007)
REFERENCE   PMID:18430459
  AUTHORS   Ouyang KJ, Woo LL, Ellis NA.
  TITLE     Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  JOURNAL   Mech Ageing Dev 129:425-40 (2008)
            DOI:10.1016/j.mad.2008.03.003
REFERENCE   PMID:15902993
  AUTHORS   Kawabata M, Kawabata T, Nishibori M.
  TITLE     Role of recA/RAD51 family proteins in mammals.
  JOURNAL   Acta Med Okayama 59:1-9 (2005)
            DOI:10.18926/AMO/31987
REFERENCE   PMID:12589470
  AUTHORS   Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  TITLE     Mitotic recombination in Saccharomyces cerevisiae.
  JOURNAL   Curr Genet 42:185-98 (2003)
            DOI:10.1007/s00294-002-0346-3
REFERENCE   PMID:16935872
  AUTHORS   Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  TITLE     Rad54: the Swiss Army knife of homologous recombination?
  JOURNAL   Nucleic Acids Res 34:4115-25 (2006)
            DOI:10.1093/nar/gkl481
REFERENCE   PMID:17395553
  AUTHORS   Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  TITLE     Recombination proteins and rescue of arrested replication forks.
  JOURNAL   DNA Repair (Amst) 6:967-80 (2007)
            DOI:10.1016/j.dnarep.2007.02.016
KO_PATHWAY  ko03440
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