ENTRY       zma03420                    Pathway
NAME        Nucleotide excision repair - Zea mays (maize)
DESCRIPTION Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP zma03420  Nucleotide excision repair
DBLINKS     GO: 0006289
ORGANISM    Zea mays (maize) [GN:zma]
GENE        103642101  DNA polymerase I A, chloroplastic [KO:K02335] [EC:2.7.7.7]
            103641202  DNA polymerase I A, chloroplastic isoform X1 [KO:K02335] [EC:2.7.7.7]
            100192928  uncharacterized protein LOC100192928 [KO:K03868] [EC:2.3.2.32]
            103634739  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
            103649912  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
            100501431  uncharacterized protein LOC100501431 [KO:K10609]
            103625822  cullin-4 [KO:K10609]
            100279448  uncharacterized protein LOC100279448 [KO:K10610]
            103635427  DNA damage-binding protein 1 [KO:K10610]
            100381699  DNA damage-binding protein 2 [KO:K10140]
            103645297  DNA repair protein RAD4 [KO:K10838]
            100274222  DNA repair protein RAD23 [KO:K10839]
            100282762  uncharacterized protein LOC100282762 [KO:K10839]
            100282427  uncharacterized protein LOC100282427 [KO:K10839]
            100283179  uncharacterized protein LOC100283179 [KO:K10839]
            100191313  uncharacterized protein LOC100191313 [KO:K10839]
            100275606  uncharacterized protein LOC100275606 [KO:K10570]
            103649923  DNA excision repair protein CSB [KO:K10841]
            100273893  uncharacterized protein LOC100273893 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
            100272776  uncharacterized protein LOC100272776 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
            100284506  CDK-activating kinase assembly factor MAT1 family protein [KO:K10842]
            103638012  RNA polymerase II transcription factor B subunit 3 [KO:K10842]
            100283483  uncharacterized protein LOC100283483 [KO:K06634]
            103651319  general transcription and DNA repair factor IIH helicase subunit XPB1 [KO:K10843] [EC:5.6.2.4]
            100285960  DNA repair helicase UVH6 [KO:K10844] [EC:5.6.2.3]
            100281631  REX1 DNA Repair family protein [KO:K10845]
            100193949  uncharacterized protein LOC100193949 isoform 1 [KO:K03141]
            100274342  uncharacterized protein LOC100274342 [KO:K03142]
            100192494  uncharacterized protein LOC100192494 isoform 1 [KO:K03143]
            103645755  general transcription and DNA repair factor IIH subunit TFB2 isoform X1 [KO:K03144]
            103632168  DNA repair protein UVH3 isoform X1 [KO:K10846]
            100285427  uncharacterized protein LOC100285427 [KO:K07466]
            100383373  uncharacterized protein LOC100383373 [KO:K07466]
            100280726  uncharacterized protein LOC100280726 [KO:K07466]
            100273584  Replication protein A DNA-binding subunit [KO:K07466]
            100285013  OB-fold nucleic acid binding domain containing protein [KO:K10739]
            100285903  OB-fold nucleic acid binding domain containing protein [KO:K10739]
            100272286  uncharacterized protein LOC100272286 [KO:K10739]
            103627452  replication protein A 32 kDa subunit B isoform X1 [KO:K10739]
            100283481  uncharacterized protein LOC100283481 [KO:K10740]
            100126965  uncharacterized protein LOC100126965 [KO:K10740]
            100285910  uncharacterized protein LOC100285910 [KO:K10740]
            100192883  DNA repair endonuclease UVH1 isoform X1 [KO:K10848] [EC:3.1.-.-]
            100192592  DNA excision repair protein ERCC-1 [KO:K10849]
            103654581  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100382167  uncharacterized protein LOC100382167 [KO:K02328]
            100194011  uncharacterized protein LOC100194011 [KO:K03504]
            100279971  uncharacterized protein LOC100279971 [KO:K03504]
            103642327  uncharacterized protein LOC103642327 [KO:K03504]
            100282638  uncharacterized protein LOC100282638 [KO:K03505]
            100280534  delta DNA polymerase [KO:K03505]
            103627197  DNA polymerase epsilon catalytic subunit A isoform X1 [KO:K02324] [EC:2.7.7.7]
            100280690  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
            100282897  uncharacterized protein LOC100282897 [KO:K02326] [EC:2.7.7.7]
            542425  proliferating cell nuclear antigen [KO:K04802]
            542357  proliferating cell nuclear antigen 2 [KO:K04802]
            103648088  replication factor C subunit 1 [KO:K10754]
            100282197  replication factor C subunit 2 [KO:K10755]
            100282678  uncharacterized protein LOC100282678 [KO:K10755]
            100216703  replication factor C subunit 3 [KO:K10756]
            100193357  uncharacterized protein LOC100193357 [KO:K10756]
            103625817  replication factor C subunit 5 [KO:K10756]
            103637697  replication factor C subunit 5 [KO:K10756]
            100383890  uncharacterized protein LOC100383890 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
REFERENCE   PMID:11436314
  AUTHORS   Sugasawa K.
  TITLE     [Molecular mechanism of mammalian nucleotide excision repair]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:893-901 (2001)
REFERENCE   PMID:11436316
  AUTHORS   Nakatsu Y.
  TITLE     [Transcription-coupled repair and Cockayne syndrome]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:908-15 (2001)
REFERENCE   PMID:11436323
  AUTHORS   Nakagawa N, Masui R, Kuramitsu S.
  TITLE     [Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:968-75 (2001)
REFERENCE   PMID:17276014
  AUTHORS   Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  TITLE     Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  JOURNAL   Neuroscience 145:1388-96 (2007)
            DOI:10.1016/j.neuroscience.2006.12.020
REFERENCE   PMID:17884153
  AUTHORS   Saldivar JS, Wu X, Follen M, Gershenson D.
  TITLE     Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  JOURNAL   Gynecol Oncol 107:S56-71 (2007)
            DOI:10.1016/j.ygyno.2007.07.043
REFERENCE   PMID:16922398
  AUTHORS   Sugasawa K.
  TITLE     [DNA repair pathways involving Cul4A ubiquitin ligases]
  JOURNAL   Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
REFERENCE   PMID:18018633
  AUTHORS   Ito S, Ando D, Tanaka K.
  TITLE     [Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  JOURNAL   Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
REL_PATHWAY zma03020  RNA polymerase
            zma04120  Ubiquitin mediated proteolysis
KO_PATHWAY  ko03420
///
