ENTRY       zma03410                    Pathway
NAME        Base excision repair - Zea mays (maize)
DESCRIPTION Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
CLASS       Genetic Information Processing; Replication and repair
PATHWAY_MAP zma03410  Base excision repair
DBLINKS     GO: 0006284 0006285 0006286 0006287 0006288
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100273102  uncharacterized protein LOC100273102 [KO:K10563] [EC:3.2.2.23 4.2.99.18]
            100273912  uncharacterized protein LOC100273912 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
            107275233  uncharacterized protein LOC107275233 [KO:K10773] [EC:4.2.99.18]
            103640763  endonuclease III homolog 1, chloroplastic isoform X1 [KO:K10773] [EC:4.2.99.18]
            100194229  uncharacterized protein LOC100194229 [KO:K01247] [EC:3.2.2.21]
            100274123  uncharacterized protein LOC100274123 [KO:K01247] [EC:3.2.2.21]
            100285587  DNA-3-methyladenine glycosylase 1 [KO:K01247] [EC:3.2.2.21]
            100273848  uncharacterized protein LOC100273848 [KO:K01246] [EC:3.2.2.20]
            100216672  uncharacterized protein LOC100216672 [KO:K01246] [EC:3.2.2.20]
            100191724  uncharacterized protein LOC100191724 [KO:K01246] [EC:3.2.2.20]
            100284031  DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
            103632764  LOW QUALITY PROTEIN: probable GMP synthase [glutamine-hydrolyzing] [KO:K01246] [EC:3.2.2.20]
            103641812  probable GMP synthase [glutamine-hydrolyzing] [KO:K01246] [EC:3.2.2.20]
            100282754  uncharacterized protein LOC100282754 [KO:K01246] [EC:3.2.2.20]
            103649150  uncharacterized protein LOC103649150 [KO:K01246] [EC:3.2.2.20]
            100284406  uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
            100284112  A/G-specific adenine DNA glycosylase [KO:K03575] [EC:3.2.2.31]
            100285435  DNA-3-methyladenine glycosylase [KO:K03652] [EC:3.2.2.21]
            100191243  uncharacterized protein LOC100191243 [KO:K01142] [EC:3.1.11.2]
            100280514  uncharacterized protein LOC100280514 isoform 1 [KO:K01142] [EC:3.1.11.2]
            103633096  DNA-(apurinic or apyrimidinic site) lyase 2 [KO:K10772] [EC:4.2.99.18]
            103642101  DNA polymerase I A, chloroplastic [KO:K02335] [EC:2.7.7.7]
            103641202  DNA polymerase I A, chloroplastic isoform X1 [KO:K02335] [EC:2.7.7.7]
            100383279  uncharacterized protein LOC100383279 [KO:K03512] [EC:2.7.7.7 4.2.99.-]
            100283527  uncharacterized protein LOC100283527 [KO:K10803]
            542425  proliferating cell nuclear antigen [KO:K04802]
            542357  proliferating cell nuclear antigen 2 [KO:K04802]
            103654581  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
            100382167  uncharacterized protein LOC100382167 [KO:K02328]
            100194011  uncharacterized protein LOC100194011 [KO:K03504]
            100279971  uncharacterized protein LOC100279971 [KO:K03504]
            103642327  uncharacterized protein LOC103642327 [KO:K03504]
            100282638  uncharacterized protein LOC100282638 [KO:K03505]
            100280534  delta DNA polymerase [KO:K03505]
            103627197  DNA polymerase epsilon catalytic subunit A isoform X1 [KO:K02324] [EC:2.7.7.7]
            100280690  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
            100282897  uncharacterized protein LOC100282897 [KO:K02326] [EC:2.7.7.7]
            100383890  uncharacterized protein LOC100383890 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
            103647201  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
            103627237  protein ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
            103635146  poly [ADP-ribose] polymerase 2 isoform X2 [KO:K10798] [EC:2.4.2.30]
            732817  flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
            100383660  uncharacterized protein LOC100383660 [KO:K04799] [EC:3.1.-.-]
REFERENCE   PMID:17893748
  AUTHORS   Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  TITLE     Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  JOURNAL   Acta Biochim Pol 54:413-34 (2007)
REFERENCE   PMID:17337257
  AUTHORS   Almeida KH, Sobol RW.
  TITLE     A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  JOURNAL   DNA Repair (Amst) 6:695-711 (2007)
            DOI:10.1016/j.dnarep.2007.01.009
REFERENCE   PMID:21665970
  AUTHORS   Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  TITLE     Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  JOURNAL   J Bacteriol 193:4495-508 (2011)
            DOI:10.1128/JB.00233-11
REFERENCE   PMID:11436317
  AUTHORS   Ikeda S, Seki S.
  TITLE     [Base excision repair: DNA glycosylase and AP endonuclease]
  JOURNAL   Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO_PATHWAY  ko03410
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