ENTRY       zma03050                    Pathway
NAME        Proteasome - Zea mays (maize)
DESCRIPTION The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
CLASS       Genetic Information Processing; Folding, sorting and degradation
PATHWAY_MAP zma03050  Proteasome
DBLINKS     GO: 0000502
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100283005  uncharacterized protein LOC100283005 [KO:K03033]
            100282792  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
            100272678  uncharacterized protein LOC100272678 [KO:K06693]
            100382103  uncharacterized protein LOC100382103 [KO:K03035]
            103627906  26S proteasome non-ATPase regulatory subunit 12 homolog A [KO:K03035]
            100193485  uncharacterized protein LOC100193485 [KO:K03036]
            100284700  uncharacterized protein LOC100284700 [KO:K03036]
            111589223  26S proteasome non-ATPase regulatory subunit 11 homolog [KO:K03036]
            100282303  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
            100282612  uncharacterized protein LOC100282612 [KO:K03037]
            100274928  uncharacterized protein LOC100274928 [KO:K03038]
            100276453  uncharacterized protein LOC100276453 [KO:K03038]
            100283395  uncharacterized protein LOC100283395 precursor [KO:K03039]
            100285832  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
            100217166  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
            103627987  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            103649975  26S proteasome non-ATPase regulatory subunit 14 homolog [KO:K03030]
            100192879  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
            100282470  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
            100280804  deleted in split hand/splt foot protein 1 [KO:K10881]
            100285717  uncharacterized protein LOC100285717 [KO:K10881]
            100272940  uncharacterized protein LOC100272940 [KO:K03029]
            100283637  26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
            100382157  uncharacterized protein LOC100382157 [KO:K03029]
            100384330  uncharacterized protein LOC100384330 [KO:K03028]
            103654920  26S proteasome non-ATPase regulatory subunit 2 homolog A [KO:K03028]
            100382965  uncharacterized protein LOC100382965 [KO:K03032]
            103645964  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            103642042  26S proteasome non-ATPase regulatory subunit 1 homolog A [KO:K03032]
            100274443  uncharacterized protein LOC100274443 [KO:K03032]
            100281651  uncharacterized protein LOC100281651 [KO:K06691]
            100274064  uncharacterized protein LOC100274064 [KO:K03061]
            100272769  uncharacterized protein LOC100272769 [KO:K03061]
            100279843  26S protease regulatory subunit 4 [KO:K03062]
            100193364  26S protease regulatory subunit 4 homolog [KO:K03062]
            100273032  uncharacterized protein LOC100273032 [KO:K03066]
            100274445  uncharacterized protein LOC100274445 [KO:K03066]
            100282100  26S protease regulatory subunit S10B [KO:K03064]
            100383510  uncharacterized protein LOC100383510 [KO:K03064]
            100273945  26S proteasome regulatory subunit 10B homolog A [KO:K03064]
            100274559  uncharacterized protein LOC100274559 [KO:K03065]
            100273594  uncharacterized protein LOC100273594 [KO:K03065]
            100284233  uncharacterized protein LOC100284233 [KO:K03063]
            542160  26S proteasome regulatory complex ATPase RPT3 [KO:K03063]
            100383447  proteasome activator subunit 4 isoform X1 [KO:K06699]
            100191154  uncharacterized protein LOC100191154 [KO:K02730] [EC:3.4.25.1]
            542021  maize 20S proteasome alpha subunit [KO:K02730] [EC:3.4.25.1]
            100283940  proteasome subunit alpha type 6 [KO:K02730] [EC:3.4.25.1]
            100193683  proteasome subunit alpha type [KO:K02726] [EC:3.4.25.1]
            103653823  uncharacterized protein LOC103653823 [KO:K02726] [EC:3.4.25.1]
            103648810  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
            100192809  uncharacterized protein LOC100192809 [KO:K02726] [EC:3.4.25.1]
            103627458  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
            103639881  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
            103645177  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
            109939198  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
            100191947  proteasome C9 1 [KO:K02728] [EC:3.4.25.1]
            100193140  proteasome subunit alpha type [KO:K02728] [EC:3.4.25.1]
            100037815  uncharacterized protein LOC100037815 [KO:K02731] [EC:3.4.25.1]
            100191224  proteasome subunit alpha type [KO:K02731] [EC:3.4.25.1]
            100193583  uncharacterized protein LOC100193583 [KO:K02731] [EC:3.4.25.1]
            100282220  proteasome subunit alpha type 5 [KO:K02729] [EC:3.4.25.1]
            100283546  proteasome subunit alpha type 5 [KO:K02729] [EC:3.4.25.1]
            100282706  proteasome subunit alpha type 1 [KO:K02725] [EC:3.4.25.1]
            100856965  proteasome subunit alpha type 1 [KO:K02725] [EC:3.4.25.1]
            100285986  proteasome subunit alpha type 3 [KO:K02727] [EC:3.4.25.1]
            100283094  proteasome subunit alpha type 3 [KO:K02727] [EC:3.4.25.1]
            100283656  uncharacterized protein LOC100283656 [KO:K02727] [EC:3.4.25.1]
            100383475  proteasome subunit alpha type [KO:K02727] [EC:3.4.25.1]
            100191806  uncharacterized protein LOC100191806 [KO:K02738] [EC:3.4.25.1]
            100272427  uncharacterized protein LOC100272427 [KO:K02738] [EC:3.4.25.1]
            100216834  uncharacterized protein LOC100216834 [KO:K02739] [EC:3.4.25.1]
            100283485  uncharacterized protein LOC100283485 [KO:K02739] [EC:3.4.25.1]
            100272320  uncharacterized protein LOC100272320 [KO:K02735] [EC:3.4.25.1]
            100274112  uncharacterized protein LOC100274112 [KO:K02735] [EC:3.4.25.1]
            100382784  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
            100282105  proteasome component 2 [KO:K02734] [EC:3.4.25.1]
            100282158  uncharacterized protein LOC100282158 [KO:K02734] [EC:3.4.25.1]
            100194311  uncharacterized protein LOC100194311 [KO:K02737] [EC:3.4.25.1]
            100280821  uncharacterized protein LOC100280821 [KO:K02732] [EC:3.4.25.1]
            100286342  proteasome subunit beta type 1 [KO:K02732] [EC:3.4.25.1]
            103632974  proteasome subunit beta type-1 isoform X1 [KO:K02732] [EC:3.4.25.1]
            103628822  proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
            100192865  proteasome subunit beta type [KO:K02736] [EC:3.4.25.1]
            100283981  proteasome subunit beta type 4 [KO:K02736] [EC:3.4.25.1]
            100276561  uncharacterized protein LOC100276561 [KO:K06700]
            100217091  putative proteasome maturation factor UMP1 family protein [KO:K11599]
            100193413  uncharacterized protein LOC100193413 [KO:K11599]
REFERENCE   PMID:16338359
  AUTHORS   Hirano Y, Murata S, Tanaka K
  TITLE     Large- and small-scale purification of mammalian 26S proteasomes.
  JOURNAL   Methods Enzymol 399:227-40 (2005)
            DOI:10.1016/S0076-6879(05)99015-0
REFERENCE   PMID:18497808
  AUTHORS   Saeki Y, Tanaka K
  TITLE     Cell biology: two hands for degradation.
  JOURNAL   Nature 453:460-1 (2008)
            DOI:10.1038/453460a
REFERENCE   PMID:16919475
  AUTHORS   Smith DM, Benaroudj N, Goldberg A
  TITLE     Proteasomes and their associated ATPases: a destructive combination.
  JOURNAL   J Struct Biol 156:72-83 (2006)
            DOI:10.1016/j.jsb.2006.04.012
REFERENCE   PMID:16181324
  AUTHORS   Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
  TITLE     Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
  JOURNAL   Immunol Rev 207:19-30 (2005)
            DOI:10.1111/j.0105-2896.2005.00308.x
REFERENCE   PMID:19483713
  AUTHORS   Darwin KH
  TITLE     Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
  JOURNAL   Nat Rev Microbiol 7:485-91 (2009)
            DOI:10.1038/nrmicro2148
REFERENCE   PMID:23495936
  AUTHORS   Tomko RJ Jr, Hochstrasser M
  TITLE     Molecular architecture and assembly of the eukaryotic proteasome.
  JOURNAL   Annu Rev Biochem 82:415-45 (2013)
            DOI:10.1146/annurev-biochem-060410-150257
REFERENCE   PMID:28583440
  AUTHORS   Budenholzer L, Cheng CL, Li Y, Hochstrasser M
  TITLE     Proteasome Structure and Assembly.
  JOURNAL   J Mol Biol 429:3500-3524 (2017)
            DOI:10.1016/j.jmb.2017.05.027
REFERENCE   PMID:29071527
  AUTHORS   Cloos J, Roeten MS, Franke NE, van Meerloo J, Zweegman S, Kaspers GJ, Jansen G
  TITLE     (Immuno)proteasomes as therapeutic target in acute leukemia.
  JOURNAL   Cancer Metastasis Rev 36:599-615 (2017)
            DOI:10.1007/s10555-017-9699-4
REFERENCE   PMID:22215586
  AUTHORS   Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  TITLE     Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
  JOURNAL   Proc Natl Acad Sci U S A 109:1479-84 (2012)
            DOI:10.1073/pnas.1119394109
REL_PATHWAY zma04120  Ubiquitin mediated proteolysis
KO_PATHWAY  ko03050
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