ENTRY       zma03015                    Pathway
NAME        mRNA surveillance pathway - Zea mays (maize)
DESCRIPTION The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP zma03015  mRNA surveillance pathway
DBLINKS     GO: 0071028
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100384700  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
            100280855  uncharacterized protein LOC100280855 [KO:K12883]
            100283725  uncharacterized protein LOC100283725 [KO:K12883]
            103641667  regulator of nonsense transcripts UPF3-like [KO:K14328]
            103646424  regulator of nonsense transcripts UPF3 [KO:K14328]
            100280761  RNA-binding protein 8A [KO:K12876]
            100283893  RNA-binding protein 8A [KO:K12876]
            100283928  uncharacterized protein LOC100283928 [KO:K12876]
            100279432  protein mago nashi [KO:K12877]
            100280575  uncharacterized protein LOC100280575 [KO:K12877]
            732749  putative RH2 protein [KO:K13025] [EC:3.6.4.13]
            103627913  eukaryotic initiation factor 4A-III homolog A [KO:K13025] [EC:3.6.4.13]
            100194333  histone deacetylase complex subunit SAP18 [KO:K14324]
            100381502  histone deacetylase complex subunit SAP18 [KO:K14324]
            100283191  pinin/SDK/memA/ protein conserved region containing protein [KO:K13114]
            100191788  putative pinin_SDK_memA domain family protein [KO:K13114]
            100381870  uncharacterized protein LOC100381870 [KO:K12875]
            100502129  uncharacterized protein LOC100502129 isoform X1 [KO:K12875]
            103635858  formin-like protein 5 isoform X2 [KO:K12875]
            103636269  uncharacterized protein LOC103636269 [KO:K14325]
            103650711  uncharacterized protein LOC103650711 [KO:K14325]
            100193488  uncharacterized protein LOC100193488 [KO:K12881]
            100279524  THO complex subunit 4 [KO:K12881]
            100272743  uncharacterized protein LOC100272743 [KO:K12881]
            100280157  THO complex subunit 4C [KO:K12881]
            100278324  uncharacterized protein LOC100278324 [KO:K12881]
            100280336  THO complex subunit 4 [KO:K12881]
            100193503  uncharacterized protein LOC100193503 [KO:K18655] [EC:3.6.4.13]
            103625787  protein GLE1 isoform X1 [KO:K18723]
            103644232  protein GLE1 [KO:K18723]
            100273717  uncharacterized protein LOC100273717 [KO:K12812] [EC:3.6.4.13]
            100384654  uncharacterized protein LOC100384654 [KO:K12812] [EC:3.6.4.13]
            100273358  uncharacterized protein LOC100273358 [KO:K14294]
            100283795  PYM protein [KO:K14294]
            100304415  splicing factor PWI domain-containing protein [KO:K13171]
            100193119  uncharacterized protein LOC100193119 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
            103646942  mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
            100193629  uncharacterized protein LOC100193629 [KO:K00565] [EC:2.1.1.56]
            100283589  mRNA [KO:K00565] [EC:2.1.1.56]
            103627789  mRNA cap guanine-N7 methyltransferase 2 [KO:K00565] [EC:2.1.1.56]
            103649720  transcription initiation factor TFIID subunit 15b [KO:K13098]
            103634842  transcription initiation factor TFIID subunit 15b [KO:K13098]
            100194063  uncharacterized protein LOC100194063 [KO:K14396]
            100282115  polyadenylate-binding protein 2 [KO:K14396]
            100283584  polyadenylate-binding protein 2 [KO:K14396]
            100285979  polyadenylate-binding protein 2 [KO:K14396]
            103628586  polyadenylate-binding protein 2 [KO:K14396]
            103638439  polyadenylate-binding protein 2 [KO:K14396]
            103640921  polyadenylate-binding protein 3 [KO:K14396]
            100282369  uncharacterized protein LOC100282369 [KO:K14397]
            100273812  uncharacterized protein LOC100273812 [KO:K14397]
            100280946  cleavage and polyadenylation specificity factor 5 [KO:K14397]
            103641415  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
            103641426  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
            100382126  uncharacterized protein LOC100382126 [KO:K14376] [EC:2.7.7.19]
            100274408  uncharacterized protein LOC100274408 [KO:K14376] [EC:2.7.7.19]
            100280371  Nuclear poly(A) polymerase 2 [KO:K14376] [EC:2.7.7.19]
            100285931  uncharacterized protein LOC100285931 [KO:K14376] [EC:2.7.7.19]
            103646013  nuclear poly(A) polymerase 4 [KO:K14376] [EC:2.7.7.19]
            103643777  nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
            103639211  nuclear poly(A) polymerase 3 [KO:K14376] [EC:2.7.7.19]
            100278989  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
            100284798  pre-mRNA cleavage complex II protein Clp1 [KO:K14399] [EC:2.7.1.78]
            103647268  uncharacterized protein LOC103647268 [KO:K14400]
            103632446  uncharacterized protein LOC103632446 [KO:K14400]
            100280286  uncharacterized protein LOC100280286 isoform 2 [KO:K14400]
            103653026  polyadenylation and cleavage factor homolog 4 isoform X2 [KO:K14400]
            103648775  probable cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
            100285191  IDP798; uncharacterized protein LOC100285191 [KO:K14402]
            100279987  uncharacterized protein LOC100279987 [KO:K14403] [EC:3.1.27.-]
            100285156  cleavage and polyadenylation specificity factor, 73 kDa subunit [KO:K14403] [EC:3.1.27.-]
            100217067  uncharacterized protein LOC100217067 isoform 2 [KO:K14404]
            103626282  zinc finger CCCH domain-containing protein 45 [KO:K14404]
            103629640  zinc finger CCCH domain-containing protein 45 [KO:K14404]
            100381986  WD repeat-containing protein 33 [KO:K15542]
            100273578  Set1 complex component swd2 [KO:K14962]
            100285923  set1 complex component swd2 [KO:K14962]
            100280358  uncharacterized protein LOC100280358 [KO:K14962]
            100285399  set1 complex component swd2 [KO:K14962]
            542269  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
            100216757  putative serine/threonine protein phosphatase superfamily protein [KO:K06269] [EC:3.1.3.16]
            100272981  uncharacterized protein LOC100272981 [KO:K06269] [EC:3.1.3.16]
            100191199  putative serine/threonine protein phosphatase superfamily protein [KO:K06269] [EC:3.1.3.16]
            103634267  serine/threonine-protein phosphatase PP1 isoform X1 [KO:K06269] [EC:3.1.3.16]
            103635487  serine/threonine-protein phosphatase PP1 isoform X1 [KO:K06269] [EC:3.1.3.16]
            100217163  uncharacterized protein LOC100217163 [KO:K06269] [EC:3.1.3.16]
            100283013  uncharacterized protein LOC100283013 [KO:K06269] [EC:3.1.3.16]
            100282306  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
            100284227  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
            100273452  uncharacterized protein LOC100273452 [KO:K15544] [EC:3.1.3.16]
            100192488  uncharacterized protein LOC100192488 [KO:K14406]
            100272317  cleavage stimulating factor 64-like [KO:K14407]
            100304208  uncharacterized protein LOC100304208 [KO:K14407]
            103651305  uncharacterized protein LOC103651305 [KO:K06100]
            103633605  uncharacterized protein LOC103633605 isoform X1 [KO:K06100]
            100193201  heterogeneous nuclear ribonucleoprotein 27C [KO:K14411]
            100279976  uncharacterized protein LOC100279976 [KO:K14411]
            100280293  uncharacterized protein LOC100280293 [KO:K14411]
            100382683  uncharacterized protein LOC100382683 [KO:K14411]
            100216861  uncharacterized protein LOC100216861 [KO:K14411]
            103647784  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
            103631917  DAZ-associated protein 1 [KO:K14411]
            103632085  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
            100285224  heterogeneous nuclear ribonucleoprotein 27C [KO:K14411]
            100192067  Ribonucleoprotein like protein [KO:K14411]
            100273889  uncharacterized protein LOC100273889 [KO:K14411]
            100285420  uncharacterized protein LOC100285420 [KO:K13126]
            100282980  uncharacterized protein LOC100282980 [KO:K13126]
            100502035  uncharacterized protein LOC100502035 [KO:K13126]
            100381531  uncharacterized protein LOC100381531 [KO:K13126]
            103639307  polyadenylate-binding protein 7 [KO:K13126]
            103641822  polyadenylate-binding protein 2 [KO:K13126]
            100383542  uncharacterized protein LOC100383542 [KO:K13126]
            100281195  eukaryotic peptide chain release factor subunit 1-1 [KO:K03265]
            100285172  eukaryotic peptide chain release factor subunit 1-1 [KO:K03265]
            103646667  eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
            100384492  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X4 [KO:K03267]
            100383288  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:3.6.4.13 5.6.2.3]
            100304236  uncharacterized protein LOC100304236 [KO:K14326] [EC:3.6.4.13 5.6.2.3]
            103627442  regulator of nonsense transcripts UPF2 [KO:K14327]
            100194141  uncharacterized protein LOC100194141 [KO:K14327]
            103643975  serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
            100278146  protein SMG7 [KO:K14409]
            100384817  uncharacterized protein LOC100384817 [KO:K14409]
            100191189  uncharacterized protein LOC100191189 [KO:K04382] [EC:3.1.3.16]
            100191902  uncharacterized protein LOC100191902 [KO:K04382] [EC:3.1.3.16]
            100272765  putative serine/threonine protein phosphatase superfamily protein [KO:K04382] [EC:3.1.3.16]
            100273101  putative serine/threonine protein phosphatase superfamily protein [KO:K04382] [EC:3.1.3.16]
            100282302  uncharacterized protein LOC100282302 [KO:K04382] [EC:3.1.3.16]
            100282834  PP2Ac-5 - Phosphatase 2A isoform 5 belonging to family 2 [KO:K04382] [EC:3.1.3.16]
            100283820  uncharacterized protein LOC100283820 [KO:K04382] [EC:3.1.3.16]
            100381284  putative serine/threonine protein phosphatase superfamily protein [KO:K04382] [EC:3.1.3.16]
            100272642  uncharacterized protein LOC100272642 [KO:K04382] [EC:3.1.3.16]
            103644573  serine/threonine-protein phosphatase PP1 isozyme 1 [KO:K04382] [EC:3.1.3.16]
            732740  uncharacterized protein LOC732740 [KO:K03456]
            100283785  uncharacterized protein LOC100283785 [KO:K03456]
            103638140  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
            100191387  uncharacterized protein LOC100191387 [KO:K04354]
            100191991  serine/threonine protein phosphatase regulatory subunit Bbeta isoform [KO:K04354]
            100193694  uncharacterized protein LOC100193694 [KO:K04354]
            100383125  uncharacterized protein LOC100383125 [KO:K04354]
            100383610  uncharacterized protein LOC100383610 [KO:K04354]
            100279229  uncharacterized protein LOC100279229 [KO:K11583]
            100282304  uncharacterized protein LOC100282304 [KO:K11583]
            100384234  uncharacterized protein LOC100384234 [KO:K11583]
            103643458  probable serine/threonine protein phosphatase 2A regulatory subunit B''delta isoform X1 [KO:K11583]
            103641393  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
            103626168  probable serine/threonine protein phosphatase 2A regulatory subunit B''delta [KO:K11583]
            732821  protein phosphatase 2A regulatory subunit B' [KO:K11584]
            100273799  uncharacterized protein LOC100273799 [KO:K11584]
            100281610  uncharacterized protein LOC100281610 [KO:K11584]
            100279581  uncharacterized protein LOC100279581 [KO:K11584]
            100279734  uncharacterized protein LOC100279734 [KO:K11584]
            100280472  uncharacterized protein LOC100280472 [KO:K11584]
            100282594  uncharacterized protein LOC100282594 [KO:K11584]
            100501635  uncharacterized protein LOC100501635 [KO:K11584]
            100382877  uncharacterized protein LOC100382877 [KO:K11584]
            103646298  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
            103647628  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform [KO:K11584]
            103628994  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
            103630073  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
            103647325  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
            103642014  HBS1-like protein isoform X1 [KO:K14416]
            103645758  HBS1-like protein isoform X1 [KO:K14416]
            103645815  protein PELOTA 1 [KO:K06965]
REFERENCE   PMID:15040442
  AUTHORS   Maquat LE
  TITLE     Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  JOURNAL   Nat Rev Mol Cell Biol 5:89-99 (2004)
            DOI:10.1038/nrm1310
REFERENCE   PMID:16723977
  AUTHORS   Amrani N, Sachs MS, Jacobson A
  TITLE     Early nonsense: mRNA decay solves a translational problem.
  JOURNAL   Nat Rev Mol Cell Biol 7:415-25 (2006)
            DOI:10.1038/nrm1942
REFERENCE   PMID:17183357
  AUTHORS   Eulalio A, Behm-Ansmant I, Izaurralde E
  TITLE     P bodies: at the crossroads of post-transcriptional pathways.
  JOURNAL   Nat Rev Mol Cell Biol 8:9-22 (2007)
            DOI:10.1038/nrm2080
REFERENCE   PMID:18158581
  AUTHORS   Mandel CR, Bai Y, Tong L
  TITLE     Protein factors in pre-mRNA 3'-end processing.
  JOURNAL   Cell Mol Life Sci 65:1099-122 (2008)
            DOI:10.1007/s00018-007-7474-3
REFERENCE   PMID:16715045
  AUTHORS   Clement SL, Lykke-Andersen J
  TITLE     No mercy for messages that mess with the ribosome.
  JOURNAL   Nat Struct Mol Biol 13:299-301 (2006)
            DOI:10.1038/nsmb0406-299
REL_PATHWAY zma03013  Nucleocytoplasmic transport
            zma03018  RNA degradation
            zma03040  Spliceosome
KO_PATHWAY  ko03015
///
