ENTRY       zma03008                    Pathway
NAME        Ribosome biogenesis in eukaryotes - Zea mays (maize)
DESCRIPTION Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
CLASS       Genetic Information Processing; Translation
PATHWAY_MAP zma03008  Ribosome biogenesis in eukaryotes
ORGANISM    Zea mays (maize) [GN:zma]
GENE        541823  CK2 regulatory subunit B1 [KO:K03115]
            542628  uncharacterized protein LOC542628 [KO:K03115]
            100274243  uncharacterized protein LOC100274243 [KO:K03115]
            100283448  casein kinase II subunit beta-4 [KO:K03115]
            541824  uncharacterized protein LOC541824 [KO:K03115]
            541825  protein kinase CK2 catalytic subunit CK2 alpha-3 [KO:K03097] [EC:2.7.11.1]
            542460  CK2 protein kinase alpha 2 [KO:K03097] [EC:2.7.11.1]
            100193188  uncharacterized protein LOC100193188 [KO:K03097] [EC:2.7.11.1]
            542637  casein kinase II subunit alpha isoform 1 [KO:K03097] [EC:2.7.11.1]
            103625865  casein kinase II subunit alpha-2 [KO:K03097] [EC:2.7.11.1]
            103629618  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
            109942013  casein kinase II subunit alpha-4, chloroplastic [KO:K03097] [EC:2.7.11.1]
            100280396  uncharacterized protein LOC100280396 [KO:K14544]
            100193550  rRNA processing 7-like [KO:K14545]
            103634524  U3 small nucleolar RNA-associated protein 5 [KO:K14546]
            103625908  WD repeat-containing protein PCN isoform X1 [KO:K14548]
            103643972  WD repeat-containing protein PCN isoform X1 [KO:K14548]
            100284315  small nucleolar ribonucleoprotein complex subunit [KO:K14549]
            100193917  uncharacterized protein LOC100193917 [KO:K14550]
            100383022  uncharacterized protein LOC100383022 [KO:K14552]
            100193563  WD repeat-containing protein 50 [KO:K14553]
            100280230  uncharacterized protein LOC100280230 [KO:K14554]
            103642006  transducin beta-like protein 3 [KO:K14555]
            100193557  Transducin family protein / WD-40 repeat family protein [KO:K14555]
            100501489  uncharacterized protein LOC100501489 [KO:K14556]
            103648282  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
            100191510  uncharacterized protein LOC100191510 [KO:K14558]
            100194088  uncharacterized protein LOC100194088 [KO:K14559]
            100193155  U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560]
            100216667  uncharacterized protein LOC100216667 [KO:K14561]
            100282167  uncharacterized protein LOC100282167 [KO:K14563] [EC:2.1.1.-]
            100283975  uncharacterized protein LOC100283975 [KO:K14564]
            103639131  nucleolar protein 56 isoform X1 [KO:K14564]
            103639139  probable nucleolar protein 5-2 [KO:K14565]
            100384739  probable nucleolar protein 5-2 [KO:K14565]
            103631271  probable nucleolar protein 5-2 [KO:K14565]
            103649398  probable nucleolar protein 5-2 [KO:K14565]
            100282785  NHP2-like protein 1 [KO:K12845]
            100303837  NHP2-like protein 1 [KO:K12845]
            103630317  NHP2-like protein 1 isoform X2 [KO:K12845]
            103633413  uncharacterized protein LOC103633413 [KO:K12845]
            103652757  NHP2-like protein 1 [KO:K12845]
            109944832  NHP2-like protein 1 [KO:K12845]
            109945944  NHP2-like protein 1 [KO:K12845]
            107521957  uncharacterized protein LOC107521957 [KO:K11131] [EC:5.4.99.-]
            100502498  uncharacterized protein LOC100502498 [KO:K11131] [EC:5.4.99.-]
            103649956  H/ACA ribonucleoprotein complex subunit 4 [KO:K11131] [EC:5.4.99.-]
            100193012  uncharacterized protein LOC100193012 [KO:K11129]
            100383935  uncharacterized protein LOC100383935 [KO:K11129]
            100193822  uncharacterized protein LOC100193822 [KO:K11128]
            100273853  putative H/ACA ribonucleoprotein complex subunit family protein [KO:K11128]
            100284497  h/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
            118472080  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
            100272977  uncharacterized protein LOC100272977 [KO:K14566]
            103638047  rRNA-processing protein FCF1 homolog [KO:K14566]
            109939174  rRNA-processing protein FCF1 homolog [KO:K14566]
            118473282  rRNA-processing protein FCF1 homolog [KO:K14566]
            118473283  rRNA-processing protein FCF1 homolog [KO:K14566]
            118473284  rRNA-processing protein FCF1 homolog [KO:K14566]
            103634670  U3 small nucleolar RNA-associated protein 14 [KO:K14567]
            100282562  ribosome biogenesis protein NEP1 [KO:K14568] [EC:2.1.1.260]
            103634616  ribosome biogenesis protein BMS1 homolog [KO:K14569]
            109941429  RNA cytidine acetyltransferase 1 [KO:K14521] [EC:2.3.1.-]
            100191832  RNA 3-terminal phosphate cyclase-like protein [KO:K11108]
            103633590  ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
            100274475  uncharacterized protein LOC100274475 [KO:K03538] [EC:3.1.26.5]
            103630287  ribonuclease P protein subunit p29 isoform X1 [KO:K03538] [EC:3.1.26.5]
            103631143  uncharacterized protein LOC103631143 [KO:K03538] [EC:3.1.26.5]
            100279072  uncharacterized protein LOC100279072 [KO:K03537] [EC:3.1.26.5]
            100272445  ribonuclease P [KO:K14525] [EC:3.1.26.5]
            100279258  uncharacterized protein LOC100279258 [KO:K03539] [EC:3.1.26.5]
            100501283  uncharacterized protein LOC100501283 [KO:K14570] [EC:3.1.-.-]
            100383366  uncharacterized protein LOC100383366 [KO:K14570] [EC:3.1.-.-]
            103645842  small RNA degrading nuclease 1 [KO:K14570] [EC:3.1.-.-]
            100192839  uncharacterized protein LOC100192839 [KO:K13288] [EC:3.1.-.-]
            103649964  5'-3' exoribonuclease 3 isoform X1 [KO:K12619] [EC:3.1.13.-]
            100285001  nucleolar GTP-binding protein 1 [KO:K06943]
            103629872  nucleolar GTP-binding protein 1 [KO:K06943]
            100273647  uncharacterized protein LOC100273647 [KO:K06943]
            100283854  nucleolar GTP-binding protein 2 [KO:K14537]
            100275579  uncharacterized protein LOC100275579 [KO:K14538]
            100274701  uncharacterized protein LOC100274701 [KO:K14538]
            103630233  cell division control protein 48 homolog C [KO:K14571]
            100279266  uncharacterized protein LOC100279266 [KO:K14571]
            100279295  uncharacterized protein LOC100279295 [KO:K14571]
            103648459  cell division control protein 48 homolog C [KO:K14571]
            103633408  cell division control protein 48 homolog C [KO:K14571]
            103630487  midasin isoform X1 [KO:K14572]
            103625805  RNA-binding protein 28 isoform X1 [KO:K14573]
            100276745  uncharacterized protein LOC100276745 [KO:K11883]
            100276770  uncharacterized protein LOC100276770 [KO:K11883]
            100193260  GTP-binding nuclear protein Ran-A1 [KO:K07936]
            100282843  uncharacterized protein LOC100282843 [KO:K07936]
            100382806  uncharacterized protein LOC100382806 [KO:K07936]
            103637360  GTP-binding nuclear protein Ran1B [KO:K07936]
            103630761  GTP-binding nuclear protein Ran-2 [KO:K07936]
            100384227  uncharacterized protein LOC100384227 [KO:K14290]
            103625708  protein EXPORTIN 1A [KO:K14290]
            100194368  uncharacterized protein LOC100194368 [KO:K07562]
            100501750  nonsense-mediated mRNA decay NMD3 family protein [KO:K07562]
            100502456  nonsense-mediated mRNA decay NMD3 family protein [KO:K07562]
            100281088  eukaryotic translation initiation factor 6 [KO:K03264]
            100282567  eukaryotic translation initiation factor 6 [KO:K03264]
            100282435  shwachman-Bodian-Diamond syndrome protein [KO:K14574]
            103643809  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
            100501989  uncharacterized protein LOC100501989 [KO:K14539] [EC:3.6.1.-]
            103632249  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
            100284024  serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
            103627813  serine/threonine-protein kinase rio1-like [KO:K07178] [EC:2.7.11.1]
            103647603  serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
            109939150  serine/threonine-protein kinase rio1-like isoform X1 [KO:K07178] [EC:2.7.11.1]
            100217272  uncharacterized protein LOC100217272 [KO:K07179] [EC:2.7.11.1]
            100280516  serine/threonine-protein kinase RIO2 [KO:K07179] [EC:2.7.11.1]
            1466357  ZemaCr120; 16S ribosomal RNA [KO:K01979]
            111590468  18S ribosomal RNA [KO:K01979]
            111589650  18S ribosomal RNA [KO:K01979]
            1466356  ZemaCr119; 23S ribosomal RNA [KO:K01982]
            100275739  26S ribosomal RNA gene [KO:K01982]
            118472434  28S ribosomal RNA [KO:K01982]
            118474940  28S ribosomal RNA [KO:K01982]
            111591091  28S ribosomal RNA [KO:K01982]
            111589670  28S ribosomal RNA [KO:K01982]
            1466353  ZemaCr116; 5S ribosomal RNA [KO:K01981]
            1466354  ZemaCr117; 5S ribosomal RNA [KO:K01981]
            111590622  5S ribosomal RNA [KO:K01981]
            111590056  small nucleolar RNA U3 [KO:K14483]
REFERENCE   PMID:20174677
  AUTHORS   Freed EF, Bleichert F, Dutca LM, Baserga SJ
  TITLE     When ribosomes go bad: diseases of ribosome biogenesis.
  JOURNAL   Mol Biosyst 6:481-93 (2010)
            DOI:10.1039/b919670f
REFERENCE   PMID:17515605
  AUTHORS   Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  TITLE     The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  JOURNAL   Mol Cell Biol 27:5414-29 (2007)
            DOI:10.1128/MCB.00380-07
REFERENCE   PMID:19850913
  AUTHORS   Strunk BS, Karbstein K
  TITLE     Powering through ribosome assembly.
  JOURNAL   RNA 15:2083-104 (2009)
            DOI:10.1261/rna.1792109
REFERENCE   PMID:15120992
  AUTHORS   Granneman S, Baserga SJ
  TITLE     Ribosome biogenesis: of knobs and RNA processing.
  JOURNAL   Exp Cell Res 296:43-50 (2004)
            DOI:10.1016/j.yexcr.2004.03.016
REFERENCE   PMID:19879902
  AUTHORS   Kressler D, Hurt E, Bassler J
  TITLE     Driving ribosome assembly.
  JOURNAL   Biochim Biophys Acta 1803:673-83 (2010)
            DOI:10.1016/j.bbamcr.2009.10.009
REL_PATHWAY zma03010  Ribosome
KO_PATHWAY  ko03008
///
