ENTRY       zma00480                    Pathway
NAME        Glutathione metabolism - Zea mays (maize)
CLASS       Metabolism; Metabolism of other amino acids
PATHWAY_MAP zma00480  Glutathione metabolism
MODULE      zma_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:zma00480]
DBLINKS     GO: 0006749
ORGANISM    Zea mays (maize) [GN:zma]
GENE        100281180  gamma-glutamyltranspeptidase 1 precursor [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            103634830  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
            100284213  cation transport protein chaC [KO:K22596] [EC:4.3.2.9]
            100193117  uncharacterized protein LOC100193117 [KO:K22596] [EC:4.3.2.9]
            109945951  uncharacterized protein LOC109945951 [KO:K22596] [EC:4.3.2.9]
            109945950  uncharacterized protein LOC109945950 [KO:K22596] [EC:4.3.2.9]
            103632484  uncharacterized protein LOC103632484 [KO:K22596] [EC:4.3.2.9]
            103637109  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
            542026  gamma-glutamylcysteine synthetase 1 [KO:K01919] [EC:6.3.2.2]
            100381846  uncharacterized protein LOC100381846 [KO:K01919] [EC:6.3.2.2]
            100273590  uncharacterized protein LOC100273590 [KO:K21456] [EC:6.3.2.3]
            542055  uncharacterized protein LOC542055 [KO:K21456] [EC:6.3.2.3]
            100381923  uncharacterized protein LOC100381923 [KO:K01255] [EC:3.4.11.1]
            103627183  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
            100280242  uncharacterized protein LOC100280242 [KO:K01256] [EC:3.4.11.2]
            100192043  glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            541828  glutathione transferase10 [KO:K00799] [EC:2.5.1.18]
            541829  glutathione transferase11 [KO:K00799] [EC:2.5.1.18]
            541830  glutathione S-transferase12 [KO:K00799] [EC:2.5.1.18]
            541831  glutathione transferase13 [KO:K00799] [EC:2.5.1.18]
            541832  glutathione transferase14 [KO:K00799] [EC:2.5.1.18]
            541834  glutathione transferase19 [KO:K00799] [EC:2.5.1.18]
            541836  glutathione S-transferase GST 21 [KO:K00799] [EC:2.5.1.18]
            541837  glutathione transferase24 [KO:K00799] [EC:2.5.1.18]
            541839  glutathione S-transferase GST 26 [KO:K00799] [EC:2.5.1.18]
            541841  glutathione transferase30 [KO:K00799] [EC:2.5.1.18]
            541847  glutathione S-transferase GST 38 [KO:K00799] [EC:2.5.1.18]
            541848  glutathione transferase39 [KO:K00799] [EC:2.5.1.18]
            541849  glutathione transferase41 [KO:K00799] [EC:2.5.1.18]
            542629  glutathione transferase 9 [KO:K00799] [EC:2.5.1.18]
            542630  glutathione S-transferase GST 15 [KO:K00799] [EC:2.5.1.18]
            542632  uncharacterized protein LOC542632 [KO:K00799] [EC:2.5.1.18]
            542633  uncharacterized protein LOC542633 [KO:K00799] [EC:2.5.1.18]
            542634  glutathione S-transferase GST 34 [KO:K00799] [EC:2.5.1.18]
            542366  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
            542388  protein IN2-1 [KO:K00799] [EC:2.5.1.18]
            542491  glutathione transferase35 [KO:K00799] [EC:2.5.1.18]
            542311  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
            103645629  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            100282090  IN2-1 protein [KO:K00799] [EC:2.5.1.18]
            542740  glutathione transferase 8 [KO:K00799] [EC:2.5.1.18]
            100216831  uncharacterized protein LOC100216831 [KO:K00799] [EC:2.5.1.18]
            541991  glutathione transferase 6 [KO:K00799] [EC:2.5.1.18]
            100280815  glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            100281225  uncharacterized protein LOC100281225 [KO:K00799] [EC:2.5.1.18]
            541840  glutathione S-transferase28 [KO:K00799] [EC:2.5.1.18]
            541850  glutathione S-transferase42 [KO:K00799] [EC:2.5.1.18]
            542631  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            541990  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
            100282447  uncharacterized protein LOC100282447 [KO:K00799] [EC:2.5.1.18]
            100282747  uncharacterized protein LOC100282747 [KO:K00799] [EC:2.5.1.18]
            542734  glutathione transferase 5 [KO:K00799] [EC:2.5.1.18]
            100285763  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
            100502255  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            100856957  glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            100285806  glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            541842  glutathione transferase31 [KO:K00799] [EC:2.5.1.18]
            541846  glutathione transferase37 [KO:K00799] [EC:2.5.1.18]
            103626044  probable glutathione S-transferase MSR-1 [KO:K00799] [EC:2.5.1.18]
            103637303  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            103637314  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
            103639633  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            541838  glutathione transferase25 [KO:K00799] [EC:2.5.1.18]
            541845  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
            542587  glutathione transferase 7 [KO:K00799] [EC:2.5.1.18]
            103650740  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
            103652802  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            103640476  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            100279004  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
            542490  glutathione transferase16 [KO:K00799] [EC:2.5.1.18]
            118471889  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
            100191219  dhar3; glutathione dehydroascorbate reductase3 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100273125  dhar1; glutathione dehydroascorbate reductase1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100285047  dhar4; glutathione dehydroascorbate reductase4 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100382696  dhar2; glutathione dehydroascorbate reductase2 precursor [KO:K21888] [EC:1.8.5.1 2.5.1.18]
            100273659  uncharacterized protein LOC100273659 [KO:K00383] [EC:1.8.1.7]
            541986  glutathione reductase 1 [KO:K00383] [EC:1.8.1.7]
            100191657  uncharacterized protein LOC100191657 [KO:K00031] [EC:1.1.1.42]
            100272371  uncharacterized protein LOC100272371 [KO:K00031] [EC:1.1.1.42]
            100217128  seed maturation protein PM41 [KO:K00031] [EC:1.1.1.42]
            100274592  uncharacterized protein LOC100274592 [KO:K00031] [EC:1.1.1.42]
            103633296  uncharacterized protein LOC103633296 isoform X2 [KO:K00031] [EC:1.1.1.42]
            541699  NADPH producing dehydrogenase of the oxidative pentose phosphate pathway [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100856973  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            541700  6-phosphogluconate dehydrogenase 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
            100284317  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100383765  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100383421  Glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100279290  uncharacterized protein LOC100279290 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            100304292  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
            541968  GP protein [KO:K00432] [EC:1.11.1.9]
            100273297  putative glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            100280060  glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
            100283257  uncharacterized protein LOC100283257 [KO:K00432] [EC:1.11.1.9]
            100272844  uncharacterized protein LOC100272844 [KO:K00432] [EC:1.11.1.9]
            103634626  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
            100037830  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
            100274319  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            103648076  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            103633099  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
            732743  spermine synthase1 [KO:K00797] [EC:2.5.1.16]
            100279222  spermidine synthase 1 isoform 2 [KO:K00797] [EC:2.5.1.16]
            100272866  uncharacterized protein LOC100272866 [KO:K00797] [EC:2.5.1.16]
            100282933  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
            100282908  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
            100193740  uncharacterized protein LOC100193740 [KO:K00434] [EC:1.11.1.11]
            100194161  uncharacterized protein LOC100194161 [KO:K00434] [EC:1.11.1.11]
            542476  ascorbate peroxidase 2 [KO:K00434] [EC:1.11.1.11]
            100193965  uncharacterized protein LOC100193965 [KO:K00434] [EC:1.11.1.11]
            100282326  APx3 - Peroxisomal Ascorbate Peroxidase [KO:K00434] [EC:1.11.1.11]
            100272974  Thylakoid lumenal 29 kDa protein chloroplastic precursor [KO:K00434] [EC:1.11.1.11]
            100283135  uncharacterized protein LOC100283135 [KO:K00434] [EC:1.11.1.11]
            103639279  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            100285887  APx1 - Cytosolic Ascorbate Peroxidase [KO:K00434] [EC:1.11.1.11]
            103634173  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            103634427  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
            110017794  uncharacterized protein LOC110017794 [KO:K10807] [EC:1.17.4.1]
            100502278  uncharacterized protein LOC100502278 [KO:K10807] [EC:1.17.4.1]
            100192012  uncharacterized protein LOC100192012 [KO:K10808] [EC:1.17.4.1]
            100284475  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
            100193273  Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
COMPOUND    C00005  NADPH
            C00006  NADP+
            C00024  Acetyl-CoA
            C00025  L-Glutamate
            C00037  Glycine
            C00051  Glutathione
            C00072  Ascorbate
            C00077  L-Ornithine
            C00097  L-Cysteine
            C00127  Glutathione disulfide
            C00134  Putrescine
            C00151  L-Amino acid
            C00315  Spermidine
            C00669  gamma-L-Glutamyl-L-cysteine
            C00750  Spermine
            C01322  RX
            C01419  Cys-Gly
            C01672  Cadaverine
            C01879  5-Oxoproline
            C02090  Trypanothione
            C02320  R-S-Glutathione
            C03170  Trypanothione disulfide
            C03646  Bis-gamma-glutamylcystine
            C03740  (5-L-Glutamyl)-L-amino acid
            C05422  Dehydroascorbate
            C05726  S-Substituted L-cysteine
            C05727  S-Substituted N-acetyl-L-cysteine
            C05729  R-S-Cysteinylglycine
            C05730  Glutathionylspermidine
            C16562  Glutathionylspermine
            C16563  Bis(glutathionyl)spermine
            C16564  Bis(glutathionyl)spermine disulfide
            C16565  Aminopropylcadaverine
            C16566  Glutathionylaminopropylcadaverine
            C16567  Homotrypanothione
            C16568  Homotrypanothione disulfide
            C16663  Tryparedoxin
            C16664  Tryparedoxin disulfide
REFERENCE   PMID:12675513
  AUTHORS   Josch C, Klotz LO, Sies H.
  TITLE     Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  JOURNAL   Biol Chem 384:213-8 (2003)
            DOI:10.1515/BC.2003.023
REFERENCE   PMID:18482986
  AUTHORS   Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  TITLE     A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  JOURNAL   J Biol Chem 283:19351-8 (2008)
            DOI:10.1074/jbc.M801034200
REFERENCE   PMID:14583094
  AUTHORS   Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  TITLE     New role for leucyl aminopeptidase in glutathione turnover.
  JOURNAL   Biochem J 378:35-44 (2004)
            DOI:10.1042/BJ20031336
REFERENCE   PMID:11157967
  AUTHORS   Suzuki H, Kamatani S, Kim ES, Kumagai H.
  TITLE     Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  JOURNAL   J Bacteriol 183:1489-90 (2001)
            DOI:10.1128/JB.183.4.1489-1490.2001
REFERENCE   PMID:15610825
  AUTHORS   Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  TITLE     Trypanothione biosynthesis in Leishmania major.
  JOURNAL   Mol Biochem Parasitol 139:107-16 (2005)
            DOI:10.1016/j.molbiopara.2004.10.004
REFERENCE   PMID:12049631
  AUTHORS   Oza SL, Ariyanayagam MR, Fairlamb AH.
  TITLE     Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  JOURNAL   Biochem J 364:679-86 (2002)
            DOI:10.1042/BJ20011370
REFERENCE   PMID:9677355
  AUTHORS   Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  TITLE     Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  JOURNAL   J Biol Chem 273:19383-90 (1998)
            DOI:10.1074/jbc.273.31.19383
REFERENCE   PMID:12750367
  AUTHORS   Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  TITLE     Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 278:27612-9 (2003)
            DOI:10.1074/jbc.M302750200
REFERENCE   PMID:12967709
  AUTHORS   Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  TITLE     Properties of trypanothione synthetase from Trypanosoma brucei.
  JOURNAL   Mol Biochem Parasitol 131:25-33 (2003)
            DOI:10.1016/S0166-6851(03)00176-2
REFERENCE   PMID:12121990
  AUTHORS   Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  TITLE     A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 277:35853-61 (2002)
            DOI:10.1074/jbc.M204403200
REFERENCE   PMID:15537651
  AUTHORS   Comini M, Menge U, Wissing J, Flohe L.
  TITLE     Trypanothione synthesis in crithidia revisited.
  JOURNAL   J Biol Chem 280:6850-60 (2005)
            DOI:10.1074/jbc.M404486200
REFERENCE   PMID:7813456
  AUTHORS   Hunter KJ, Le Quesne SA, Fairlamb AH.
  TITLE     Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  JOURNAL   Eur J Biochem 226:1019-27 (1994)
            DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
REFERENCE   PMID:12751784
  AUTHORS   Krauth-Siegel RL, Meiering SK, Schmidt H.
  TITLE     The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  JOURNAL   Biol Chem 384:539-49 (2003)
            DOI:10.1515/BC.2003.062
REFERENCE   PMID:18395526
  AUTHORS   Krauth-Siegel RL, Comini MA.
  TITLE     Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  JOURNAL   Biochim Biophys Acta 1780:1236-48 (2008)
            DOI:10.1016/j.bbagen.2008.03.006
REFERENCE   PMID:8892297
  AUTHORS   Krauth-Siegel RL, Ludemann H.
  TITLE     Reduction of dehydroascorbate by trypanothione.
  JOURNAL   Mol Biochem Parasitol 80:203-8 (1996)
            DOI:10.1016/0166-6851(96)02689-8
REFERENCE   PMID:11150302
  AUTHORS   Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  TITLE     Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  JOURNAL   J Biol Chem 276:10602-6 (2001)
            DOI:10.1074/jbc.M010352200
REFERENCE   PMID:12949079
  AUTHORS   Schmidt H, Krauth-Siegel RL.
  TITLE     Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  JOURNAL   J Biol Chem 278:46329-36 (2003)
            DOI:10.1074/jbc.M305338200
REFERENCE   PMID:9851611
  AUTHORS   Tetaud E, Fairlamb AH.
  TITLE     Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  JOURNAL   Mol Biochem Parasitol 96:111-23 (1998)
            DOI:10.1016/S0166-6851(98)00120-0
REFERENCE   PMID:12446213
  AUTHORS   Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  TITLE     Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  JOURNAL   Free Radic Biol Med 33:1552-62 (2002)
            DOI:10.1016/S0891-5849(02)01089-4
REFERENCE   PMID:10713147
  AUTHORS   Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  TITLE     Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  JOURNAL   J Biol Chem 275:8220-5 (2000)
            DOI:10.1074/jbc.275.11.8220
REFERENCE   PMID:17922848
  AUTHORS   Konig J, Fairlamb AH.
  TITLE     A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  JOURNAL   FEBS J 274:5643-58 (2007)
            DOI:10.1111/j.1742-4658.2007.06087.x
REFERENCE   PMID:12466271
  AUTHORS   Hillebrand H, Schmidt A, Krauth-Siegel RL.
  TITLE     A second class of peroxidases linked to the trypanothione metabolism.
  JOURNAL   J Biol Chem 278:6809-15 (2003)
            DOI:10.1074/jbc.M210392200
REFERENCE   PMID:14982633
  AUTHORS   Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  TITLE     Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  JOURNAL   Mol Microbiol 51:1401-12 (2004)
            DOI:10.1046/j.1365-2958.2003.03913.x
REFERENCE   PMID:6798961
  AUTHORS   Pegg AE, Shuttleworth K, Hibasami H.
  TITLE     Specificity of mammalian spermidine synthase and spermine synthase.
  JOURNAL   Biochem J 197:315-20 (1981)
            DOI:10.1042/bj1970315
REL_PATHWAY zma00220  Arginine biosynthesis
            zma00250  Alanine, aspartate and glutamate metabolism
            zma00270  Cysteine and methionine metabolism
            zma00430  Taurine and hypotaurine metabolism
            zma00460  Cyanoamino acid metabolism
KO_PATHWAY  ko00480
///
